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Year Number of Results
1946 3
1947 4
1948 3
1949 3
1950 3
1951 11
1952 9
1953 6
1954 12
1955 7
1956 5
1957 14
1958 14
1959 17
1960 19
1961 19
1962 23
1963 46
1964 61
1965 70
1966 180
1967 215
1968 214
1969 200
1970 209
1971 186
1972 199
1973 231
1974 295
1975 368
1976 407
1977 602
1978 981
1979 1194
1980 15686
1981 33526
1982 34551
1983 35009
1984 36720
1985 37424
1986 38598
1987 39963
1988 41076
1989 42718
1990 44830
1991 46118
1992 46704
1993 47434
1994 48928
1995 49315
1996 49503
1997 49844
1998 50835
1999 52351
2000 54931
2001 56281
2002 59369
2003 63593
2004 71256
2005 77914
2006 86503
2007 93089
2008 103219
2009 110021
2010 119403
2011 128479
2012 133065
2013 138239
2014 139605
2015 140736
2016 136140
2017 131548
2018 133807
2019 135257
2020 147723
2021 154889
2022 142623
2023 143029
2024 133912
2025 104943
2026 627

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Page 1
Impact of a Revised Ryan White Part A HIV Care Coordination Program on Viral Suppression and Durable Viral Suppression.
Avoundjian T, Robertson MM, Abdelqader F, Braunstein SL, Nash D, Irvine MK. Avoundjian T, et al. J Acquir Immune Defic Syndr. 2026 Jan 1;101(1):77-85. doi: 10.1097/QAI.0000000000003768. J Acquir Immune Defic Syndr. 2026. PMID: 41380170
BACKGROUND: In 2018, the New York City Health Department implemented a revised care coordination program (CCR) to facilitate delivery and strengthen the impact of an already effective intervention among people with HIV (PWH) struggling with viral suppression (VS). . …
BACKGROUND: In 2018, the New York City Health Department implemented a revised care coordination program (CCR) to facilitate d …
The Impact of Childhood Household Violence on HIV-Related Outcomes in People With HIV in the United States: The Role of Psychological Distress and Social Stressors.
Schnarrs PW, Nash P, Ruderman SA, Crane HM, Delaney J, Singleton M, Dorri AA, Whitney BM, Fredericksen R, Lopez C, Burkholder G, Kitahata MM, Moore RD, Gripshover B, Karris M, Greene M, O'Cleirigh C, Farel C, Mayer KH, Willig A, Saag MS, Webel A. Schnarrs PW, et al. J Acquir Immune Defic Syndr. 2026 Jan 1;101(1):60-68. doi: 10.1097/QAI.0000000000003772. J Acquir Immune Defic Syndr. 2026. PMID: 41380169
BACKGROUND: Psychological distress (eg, depression) and social stressors (eg, HIV-related stigma) can affect HIV-related outcomes such as antiretroviral therapy adherence and health-related quality of life (HRQL). ...CONCLUSIONS: CHV has an adverse impact on soci …
BACKGROUND: Psychological distress (eg, depression) and social stressors (eg, HIV-related stigma) can affect HIV-related outcomes suc …
Effectiveness of 2023-2024 Coronavirus Disease 2019 (COVID-19) Vaccines in Pregnant Women.
Ciesla AA, Lazariu V, Watts JA, Vazquez-Benitez G, Dascomb K, Irving SA, Klein NP, Grannis SJ, Ong TC, Ball SW, DeSilva M, Sheffield T, Bride D, Van Otterloo J, Arndorfer J, Naleway AL, Koppolu P, Fireman B, Hansen J, Timbol J, Dixon BE, Rogerson C, Fadel W, Barron MA, Mayer D, Chavez C, Zhuang Y, Cheung A, Reichle L, Natarajan K, Payne AB, Link-Gelles R, Zerbo O. Ciesla AA, et al. Obstet Gynecol. 2025 Dec 11. doi: 10.1097/AOG.0000000000006145. Online ahead of print. Obstet Gynecol. 2025. PMID: 41380159
Using a test-negative design, we assessed the effectiveness of 2023-2024 COVID-19 vaccines against COVID-19-associated emergency department (ED) and urgent care setting encounters among pregnant women aged 18-45 years presenting for care with COVID-19 symptoms from Septemb …
Using a test-negative design, we assessed the effectiveness of 2023-2024 COVID-19 vaccines against COVID-19-associated emergency departme …
Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations.
Kuehn HS, Gil Silva AA, Klangkalya N, Esteve-Sole A, Goel S, Niemela JE, Stoddard JL, Chong H, Williams KW, Ip W, Framil Seoane M, Loganathan SK, Anantharachagan A, García-Soidán A, Shaffren SB, Bindernagel C, Mendez P, Miller RZ, Abolhassani H, Hoytema van Konijnenburg DP, Geerlinks AV, Cabanillas D, Zonneveld-Huijssoon E, Rutgers A, Tangye SG, Ma CS, Grey A, O'Young P, Aldave Becerra JC, Lyons JJ, White A, Claiborne M, Doroudchi A, Modena BD, Milner JD, Solanich X, Farela Neves J, Platt C, Hammarström L, Routes J, Verbsky J, Butte M, Lesmana H, Griffiths WJ, Kumararatne DS, Hauck F, Allende LM, Rodríguez-Gallego C, Elfeky R, Rubin TS, Boztug K, Fleisher TA, Rosenzweig SD. Kuehn HS, et al. Blood Adv. 2025 Dec 11:bloodadvances.2025017243. doi: 10.1182/bloodadvances.2025017243. Online ahead of print. Blood Adv. 2025. PMID: 41380100
Among them, 15 of the patient-detected variants, primarily mapping to IKAROS DNA-binding or dimerization domains, and at least 21 of the laboratory-generated mutations, impaired IKAROS function and could explain or result in human disease. VUS located in between IKAROS DNA …
Among them, 15 of the patient-detected variants, primarily mapping to IKAROS DNA-binding or dimerization domains, and at least 21 of the lab …
When do platform trials in chronic pain make sense?
Robinson-Papp J, Rathmell JP, Tarpey T, Troxel AB. Robinson-Papp J, et al. Pain. 2025 Dec 9. doi: 10.1097/j.pain.0000000000003882. Online ahead of print. Pain. 2025. PMID: 41380093 No abstract available.
Cryo-EM Analysis in CASP16.
Mulvaney T, Kryshtafovych A, Topf M. Mulvaney T, et al. Proteins. 2025 Dec 11. doi: 10.1002/prot.70099. Online ahead of print. Proteins. 2025. PMID: 41380080
Emergency Medicine Residents' Performance with National Institutes of Health Stroke Scale and Its Impact on Key Stroke-care Metrics.
Roces M, Alacala-Arcos T, Addo N, Boyle M, Hewlett M, Nguyen R, Wong A, Peabody CR, Madhok DY. Roces M, et al. West J Emerg Med. 2025 Oct 21;26(6):1764-1768. doi: 10.5811/westjem.39671. West J Emerg Med. 2025. PMID: 41380065
BACKGROUND: Emergency medicine (EM) physicians commonly use the National Institutes of Health Stroke Scale (NIHSS) to assess acute ischemic strokes in community settings. ...Our intervention found that EM resident-led NIHSS assessment did not prolong DTCT, DT …
BACKGROUND: Emergency medicine (EM) physicians commonly use the National Institutes of Health Stroke Scale (NIHSS) to a …
Computationally efficient whole-genome quantile regression at biobank scale.
Wang F, Wang C, Wang T, Masala M, Fiorillo E, Devoto M, Cucca F, Ionita-Laza I. Wang F, et al. Proc Natl Acad Sci U S A. 2025 Dec 16;122(50):e2513007122. doi: 10.1073/pnas.2513007122. Epub 2025 Dec 11. Proc Natl Acad Sci U S A. 2025. PMID: 41380003
To cite just one interesting example, using quantile regression, we are able to show that even though variants at the G6PC2 locus increase glucose levels, their effects are much stronger at lower quantiles of glucose level distribution than at higher quantiles, suggesting that G6 …
To cite just one interesting example, using quantile regression, we are able to show that even though variants at the G6PC2 locus increase g …
MBNL loss of function in smooth muscle as a model for myotonic dystrophy associated gastrointestinal dysmotility.
Peterson JAM, Frias JA, Miller AN, Soni KG, Zhang Y, Xia Z, Day JW, Preidis GA, Cooper TA. Peterson JAM, et al. Proc Natl Acad Sci U S A. 2025 Dec 16;122(50):e2522788122. doi: 10.1073/pnas.2522788122. Epub 2025 Dec 11. Proc Natl Acad Sci U S A. 2025. PMID: 41379996
Smooth muscle from the jejunum and colon showed no histopathology suggesting an intrinsic defect and contained increased phosphorylation of the 20 kDa myosin light chain (Mlc20), consistent with increased contraction. RNA sequencing of mouse and human DM1 GI samples enrich …
Smooth muscle from the jejunum and colon showed no histopathology suggesting an intrinsic defect and contained increased phosphorylation of …
Effectiveness of 2024-2025 COVID-19 Vaccines in Children in the United States - VISION, August 29, 2024-September 2, 2025.
Irving SA, Rowley EAK, Chickery S, Natarajan K, Klein NP, Grannis SJ, Ong TC, Ball SW, DeSilva MB, Dascomb K, Naleway AL, Stockwell MS, Stephens AB, Zerbo O, Hansen J, Block L, Jacobson KB, Dixon BE, Rogerson C, Duszynski T, Barron MA, Mayer D, Chavez C, Weber ZA, Reese SE, Essien I, Sheffield T, Bride D, Arndorfer J, Van Otterloo J, Koppolu P, Mak J, Kautz A, DeCuir J, Wiegand RE, Payne AB, Link-Gelles R. Irving SA, et al. MMWR Morb Mortal Wkly Rep. 2025 Dec 11;74(40):607-614. doi: 10.15585/mmwr.mm7440a1. MMWR Morb Mortal Wkly Rep. 2025. PMID: 41379943
Investigators used a test-negative case-control design to estimate vaccine effectiveness (VE) of 2024-2025 COVID-19 vaccines against COVID-19-associated emergency department or urgent care (ED/UC) visits during August 29, 2024-September 2, 2025, among immunocompetent child …
Investigators used a test-negative case-control design to estimate vaccine effectiveness (VE) of 2024-2025 COVID-19 vaccines against COVID-1 …
To Evaluate the Efficacy of Zero-Shot Prompting Using Large Language Models in the Extraction of Microbial Keratitis Descriptors.
Aruljyothi L, Mungle T, Woodward MA, Prajna V, Nuijts RMMA, Berendschot TTJM, Nallasamy N. Aruljyothi L, et al. Cornea. 2025 Dec 9. doi: 10.1097/ICO.0000000000004049. Online ahead of print. Cornea. 2025. PMID: 41379872
PURPOSE: To extract microbial keratitis (MK) descriptors from clinician notes in electronic health records using Large Language Models (LLMs) with a zero-shot prompting approach and compare the descriptors with those identified by expert human annotators. ...CONCLUS …
PURPOSE: To extract microbial keratitis (MK) descriptors from clinician notes in electronic health records using Large Language Model …
Establishing biomarkers and clinical endpoints in myotonic dystrophy type 1 (END-DM1): Protocol of an international natural history study.
Mul K, Eichinger K, Hung M, Sansone VA, Gagnon C, Subramony S, Roxburgh RH, Hamel J, Statland JM, Elsheikh B, Turner C, Sampson J, Ragole T, Matthews E, Schoser B, Swenson A, Laverty C, Shieh P, Greene EP, Takahashi M, Wicklund M, Dekdebrun J, Raymond J, DeSpain E, Thornton CA, Johnson NE; Myotonic Dystrophy Clinical Research Network. Mul K, et al. PLoS One. 2025 Dec 11;20(12):e0331163. doi: 10.1371/journal.pone.0331163. eCollection 2025. PLoS One. 2025. PMID: 41379803
Molecular targets have been identified and targeted therapies are being developed and tested in first-in-human clinical trials. However, insufficient knowledge of the phenotypic heterogeneity and natural course of the disease, together with a lack of reliable biomarkers, c …
Molecular targets have been identified and targeted therapies are being developed and tested in first-in-human clinical trials. Howev …
Life satisfaction and blood pressure: A coordinated analysis of 16 cohorts.
Park Y, Kubzansky LD, Mendes WB. Park Y, et al. Health Psychol. 2025 Dec 11. doi: 10.1037/hea0001565. Online ahead of print. Health Psychol. 2025. PMID: 41379697
OBJECTIVE: Research suggests that high life satisfaction is related to better health outcomes, but its relationship with blood pressure, a key indicator of cardiovascular health, remains inconclusive. ...CONCLUSION: These findings highlight the importance of disting …
OBJECTIVE: Research suggests that high life satisfaction is related to better health outcomes, but its relationship with blood pressu …
The daily cost of constant watchfulness: Racism-related vigilance links racial discrimination to internalizing problems in ethnoracially minoritized youth.
Galán CA, Wen W, Bernard DL, Wang MT. Galán CA, et al. Dev Psychol. 2025 Dec 11. doi: 10.1037/dev0002114. Online ahead of print. Dev Psychol. 2025. PMID: 41379656
To address this gap, the present study utilized an intensive daily diary design to examine the extent to which racism-related vigilance mediates the association between racial discrimination and internalizing problems among ethnoracially minoritized adolescents. A nationally …
To address this gap, the present study utilized an intensive daily diary design to examine the extent to which racism-related vigilance medi …
Exploring the role of telling teachers about identity-based harassment in relation to psychological distress among a national sample of sexual and gender diverse youth.
McCauley PS, Lessard LM, Moody RL, Eaton LA, Watson RJ. McCauley PS, et al. Sch Psychol. 2025 Dec 11. doi: 10.1037/spq0000726. Online ahead of print. Sch Psychol. 2025. PMID: 41379648
Yet, little is known about how reporting peer harassment to teachers and staff is associated with emotional distress among adolescents with stigmatized sexual and/or gender identities experiencing discriminatory harassment. The present study leveraged a large national samp …
Yet, little is known about how reporting peer harassment to teachers and staff is associated with emotional distress among adolescents with …
Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome.
Nielsen T, Kervadec A, Theis JL, Missinato MA, Marchant J, Romero M, Marchetti K, Lamba A, Zeng XI, Berenguer M, Walls SM, Schroeder A, Birker K, Duester G, Grossfeld P, Nelson TJ, Olson TM, Ocorr K, Bodmer R, Vogler G, Colas AR. Nielsen T, et al. Elife. 2025 Dec 11;14:RP106231. doi: 10.7554/eLife.106231. Elife. 2025. PMID: 41379537
To identify regulators of cardiomyocyte (CM) proliferation relevant to HLHS, we performed a genome-wide siRNA screen in human iPSC-derived CMs, revealing ribosomal protein (RP) genes as the most prominent effectors of CM proliferation. ...
To identify regulators of cardiomyocyte (CM) proliferation relevant to HLHS, we performed a genome-wide siRNA screen in human iPSC-de …
Midchildhood Obesity After Exposure to Gestational Diabetes Mellitus: The SWIFT Study in Youth.
Josefson JL, King AS, Sun B, Quesenberry CP Jr, Greenspan LC, Davis J, Lo JC, Faith M, Gunderson EP. Josefson JL, et al. Diabetes Care. 2025 Dec 11:dc251093. doi: 10.2337/dc25-1093. Online ahead of print. Diabetes Care. 2025. PMID: 41379482
Mothers' GDM diagnosis timing (early [<24 weeks gestation] vs. standard [24 weeks]), treatment type, and meeting of self-monitored glycemic targets, along with children's weight and height at ages 5-11 years, were obtained from Kaiser Permanente Northern California electronic …
Mothers' GDM diagnosis timing (early [<24 weeks gestation] vs. standard [24 weeks]), treatment type, and meeting of self-monitored glycem …
[Plasticization strengthening of the structure of porous biocompatible biodegradable matrices based on polylactoglycolide and its effect on cellular adhesion].
Mironov AV, Vasilyev AV, Nedorubova IA, Mironova OA, Paymeteva DS, Kulakov AA. Mironov AV, et al. Stomatologiia (Mosk). 2025;104(6. Vyp. 2):12-18. doi: 10.17116/stomat202510406212. Stomatologiia (Mosk). 2025. PMID: 41379405 Russian.
When studying the adhesion of MMSCs to the surface of matrices, a quantitative assessment of cellular adhesion was performed by calculating at least 15 fields of view in the ImageJ program (NIH, USA). RESULTS: It has been found that as the plasticizer treatment time increa …
When studying the adhesion of MMSCs to the surface of matrices, a quantitative assessment of cellular adhesion was performed by calculating …
Self-Efficacy Is Associated with Health Behaviors Related To Obesity and Cardiovascular Risk Among Hispanic/Latinx and Somali Immigrants To the United States.
Tranby B, Sia I, Clark M, Novotny P, Lohr A, Suarez Pardo L, Patten C, Iteghete S, Zeratsky K, Rieck T, Molina L, Porraz Capetillo G, Ahmed Y, Dirie H, Wieland M. Tranby B, et al. J Immigr Minor Health. 2025 Dec 11. doi: 10.1007/s10903-025-01812-9. Online ahead of print. J Immigr Minor Health. 2025. PMID: 41379348
Self-efficacy theory proposes that confidence to engage in a health behavior is associated with engaging in that specific behavior. Most research examining self-efficacy has been conducted with white young adult populations. ...
Self-efficacy theory proposes that confidence to engage in a health behavior is associated with engaging in that specific behavior. M …
Individual and Community-level Determinants of Osteoporosis Treatment Following Fracture Among Medicare Beneficiaries.
Wu H, Liu Y, Zhang J, Sen B, Curtis JR. Wu H, et al. J Gen Intern Med. 2025 Dec 11. doi: 10.1007/s11606-025-10090-y. Online ahead of print. J Gen Intern Med. 2025. PMID: 41379347
Key factors included preventive-service use in the prior year, community social determinants of health (SDoH) factors derived by exploratory factor analysis, and individual demographics and comorbidities. ...KEY RESULTS: Only 11.9% of patients were treated before fr …
Key factors included preventive-service use in the prior year, community social determinants of health (SDoH) factors derived …
Generation of iPSC-Derived iNKT Cells with Pro-Hematopoietic Activity.
Kumar A, Ferguson S, D'Souza SS, Bharadwaj NS, Raymond M, Gumperz JE, Slukvin II. Kumar A, et al. Stem Cell Rev Rep. 2025 Dec 11. doi: 10.1007/s12015-025-11031-2. Online ahead of print. Stem Cell Rev Rep. 2025. PMID: 41379300
Human invariant natural killer T (iNKT) cells are a conserved population of innate-like T cells that are activated by glycolipid antigens. In addition to their well-known role in anti-tumor function, iNKT cells are also involved in regulating and maintaining hematopoiesis …
Human invariant natural killer T (iNKT) cells are a conserved population of innate-like T cells that are activated by glycolipid anti …
Patient-Reported Outcomes During the Acute Treatment of Migraine with Zavegepant Nasal Spray: Results from a 52-Week, Open-Label Study.
Lipton RB, Mosher L, Fountaine RJ. Lipton RB, et al. Pain Ther. 2025 Dec 11. doi: 10.1007/s40122-025-00800-z. Online ahead of print. Pain Ther. 2025. PMID: 41379282
Migraine is a significant cause of ill health and disability that reduces patients' quality of life. Zavegepant nasal spray is an acute treatment for migraine that helps stop a migraine attack. ...
Migraine is a significant cause of ill health and disability that reduces patients' quality of life. Zavegepant nasal spray is an acu …
Interventions to improve adherence to oral endocrine therapy for prevention or treatment of breast cancer in Black women of low socioeconomic status.
Johnson Powell C, Adigwe A, Ekezie N, Fatima B, Majd Z, Collins R, Houk K, Patel T, Ma H, Shimko R, Ononogbu O, Abughosh S, Trivedi MV. Johnson Powell C, et al. Support Care Cancer. 2025 Dec 11;34(1):24. doi: 10.1007/s00520-025-10247-9. Support Care Cancer. 2025. PMID: 41379146
METHODS: This prospective study included adult, Black women on OET for either the prevention or treatment of breast cancer (BC) at Harris Health in Houston, TX, USA. The first intervention was a motivational interviewing (MI)-based telephone intervention consisting of six …
METHODS: This prospective study included adult, Black women on OET for either the prevention or treatment of breast cancer (BC) at Harris …
From Research Influencers to Substance Use Policymakers: Bibliometrics Demonstrate Translation from Research to Policy.
Llewellyn NM, Weber A, Kegley S, Nehl EJ, Abraham AJ. Llewellyn NM, et al. J Stud Alcohol Drugs. 2025 Dec 11. doi: 10.15288/jsad.25-00069. Online ahead of print. J Stud Alcohol Drugs. 2025. PMID: 41379088
To address this growing epidemic, governments have implemented a range of SU-related policies. The NIH's Clinical & Translational Science Awards (CTSA) program, which aims to accelerate translation of research findings into health impact, may advance translation …
To address this growing epidemic, governments have implemented a range of SU-related policies. The NIH's Clinical & Translational …
Behavioral Economics and Medication Adherence for Hypertension: A Randomized Clinical Trial.
Dodson JA, Adhikari S, Schoenthaler AM, Shimbo D, Berman AN, Levy N, Hanley K, Richardson S, Varghese A, Meng Y, Pena S, de Brito S, Gutierrez Y, Rojas M, Rosado V, Olkhinha E, Troxel AB. Dodson JA, et al. J Am Coll Cardiol. 2025 Nov 18:S0735-1097(25)10073-9. doi: 10.1016/j.jacc.2025.10.062. Online ahead of print. J Am Coll Cardiol. 2025. PMID: 41379039
BACKGROUND: Nonadherence to antihypertensive medications is common. Mobile health (mHealth)-based behavioral economic interventions may improve adherence, but remain largely untested, especially in vulnerable populations. ...
BACKGROUND: Nonadherence to antihypertensive medications is common. Mobile health (mHealth)-based behavioral economic interventions m …
C-reactive protein and cardiovascular risk in the general population.
Kurt B, Reugels M, Schneider KM, Spiesshoefer J, Milzi A, Gombert A, Fordyce CB, Wenzl FA, Pagidipati NJ, Rocha V, Fudim M, Sharma A, Lehrke M, Shimokawa H, Liuzzo G, Tokgozoglu L, Crea F, Lüscher TF, Libby P, Ridker PM, Marx N, Schneider CV, Kahles F. Kurt B, et al. Eur Heart J. 2025 Dec 11:ehaf937. doi: 10.1093/eurheartj/ehaf937. Online ahead of print. Eur Heart J. 2025. PMID: 41378999
Single Position Lumbar Spine Interbody Fusion and Pedicle Screw Placement Reduces Operating Room Costs.
Ball JR, Hopkins B, Ton A, Hang N, Bajouri Z, Mills ES, Hernandez F, Kebaish K, Abdou MA, Athari M, Avetisian H, Karakash WJ, Alluri RK, Hah RJ. Ball JR, et al. Clin Spine Surg. 2025 Nov 18. doi: 10.1097/BSD.0000000000001993. Online ahead of print. Clin Spine Surg. 2025. PMID: 41378964
METHODS: Patients who underwent SP versus DP approaches for LLIF or ALIF at a single institution were identified. Cost data, demographics, complications, operative variables, and surgical details were compared between SP and DP cohorts. ...
METHODS: Patients who underwent SP versus DP approaches for LLIF or ALIF at a single institution were identified. Cost data, demograp …
Let's Not Keep Acute Chest Syndrome Under an Umbrella.
Klings ES, Cohen R, Ruhl AP. Klings ES, et al. Am J Respir Crit Care Med. 2025 May;211(5):689-690. doi: 10.1164/rccm.202503-0639ED. Am J Respir Crit Care Med. 2025. PMID: 41378936 No abstract available.
The Long-Term Effects of Cost-Related Nonadherence on COPD Outcomes and Progression in the COPDGene Study Cohort.
Suri R, Non A, Bailey J, Conrad D. Suri R, et al. Chronic Obstr Pulm Dis. 2025 Dec 9. doi: 10.15326/jcopdf.2025.0689. Online ahead of print. Chronic Obstr Pulm Dis. 2025. PMID: 41378823
STUDY DESIGN AND METHODS: We identified 2,521 participants with baseline COPD and having answered the social and economic questionnaire in the COPDGene cohort. Of these, 408 participants endorsed experiencing CRN. Multivariable regression models were utilized to assess the …
STUDY DESIGN AND METHODS: We identified 2,521 participants with baseline COPD and having answered the social and economic questionnai …
Effects Among the Affected.
Montoya LM, Geng EH, Valancius M, Kosorok MR, Petersen ML. Montoya LM, et al. Stat Med. 2025 Dec;44(28-30):e70353. doi: 10.1002/sim.70353. Stat Med. 2025. PMID: 41378739
Primary extra-gastrointestinal stromal tumor of the gallbladder: A case report.
Wang P, Zhu CR, Yao J, Xu P, Zhang K, Zhu J, Ge XY, Chen Y, Wang WZ. Wang P, et al. World J Gastroenterol. 2025 Dec 7;31(45):113690. doi: 10.3748/wjg.v31.i45.113690. World J Gastroenterol. 2025. PMID: 41378324 Free PMC article.
According to the 2017 Chinese consensus on GISTs, based on the modified NIH 2008 criteria, the tumor was classified as very low risk. Consequently, the patient did not receive adjuvant targeted therapy such as imatinib, and the patient remained disease-free during a 6-mont …
According to the 2017 Chinese consensus on GISTs, based on the modified NIH 2008 criteria, the tumor was classified as very low risk. …
Factors associated with seeking and receiving home antiviral therapy during the coronavirus disease 2019 (COVID-19) pandemic.
Quan SF, Weaver MD, Czeisler MÉ, Booker LA, Howard ME, Jackson ML, McDonald CF, Ridgers A, Robbins R, Varma P, Rajaratnam SMW, Czeisler CA. Quan SF, et al. Discov Public Health. 2025;22(1):806. doi: 10.1186/s12982-025-01192-3. Epub 2025 Dec 8. Discov Public Health. 2025. PMID: 41377687 Free PMC article.
BACKGROUND: Home antiviral treatment (HAVT: nirmatrelvir/ritonavir [Paxlovid] and molnupiravir [Lagevrio]) for COVID-19 was approved in December 2021 by the U.S. Food and Drug Administration, but ensuing utilization during the Coronavirus Disease 2019 (COVID-19) pan …
BACKGROUND: Home antiviral treatment (HAVT: nirmatrelvir/ritonavir [Paxlovid] and molnupiravir [Lagevrio]) for COVID-19 was approved in Dece …
Harliku (nitisinone): first FDA-approved disease-modifying therapy for alkaptonuria.
Chandani HK, Hujjat SFZ, Chandani DK, Khan MS, Mahmoud A. Chandani HK, et al. Ann Med Surg (Lond). 2025 Oct 6;87(12):7877-7879. doi: 10.1097/MS9.0000000000004033. eCollection 2025 Dec. Ann Med Surg (Lond). 2025. PMID: 41377225 Free PMC article.
Until recently, apart from supportive management which involved orthopedic surgery and symptomatic treatment, there was no attempt to slow the progress of the disease. On 19 June 2025, the U.S. Food and Drug Administration approved Harliku (nitisinone) as the first …
Until recently, apart from supportive management which involved orthopedic surgery and symptomatic treatment, there was no attempt to slow t …
Survey of physicians' approaches to the clinical evaluation of interstitial lung disease in Singapore (SoPhoCLES).
Teo FSW, Chai GT, Low SY, Tay TR, Walsh SLF, Kokosi M, Takahashi M, Cottin V, Wuyts WA, Chua F, Lee P, Teo LLS, Kaw G, Ng YL, Shen L, Teoh CM, Song JW. Teo FSW, et al. J Thorac Dis. 2025 Nov 30;17(11):9439-9450. doi: 10.21037/jtd-2025-1365. Epub 2025 Nov 25. J Thorac Dis. 2025. PMID: 41377003 Free PMC article.
Our study compared approaches between ILD (fellowship-trained and providing dedicated ILD services) and non-ILD physicians in Singapore. METHODS: Between October 2017 and January 2018, non-ILD respiratory physicians from public hospitals in Singapore were invited to partic …
Our study compared approaches between ILD (fellowship-trained and providing dedicated ILD services) and non-ILD physicians in Singapo …
The role of targetable biomarker alterations in overall survival for non-small cell lung cancer (NSCLC) in a large integrated health system.
Jarrin Lopez A, Sakoda LC, Tupper HI, Yang J, Carroway WP, Williams K, Suga JM, Ragavan M, Velotta JB. Jarrin Lopez A, et al. J Thorac Dis. 2025 Nov 30;17(11):9670-9679. doi: 10.21037/jtd-2025-1043. Epub 2025 Nov 25. J Thorac Dis. 2025. PMID: 41376954 Free PMC article.
This study aims to evaluate the association between specific oncogenic biomarker alterations and overall survival (OS) across all stages of NSCLC in a large, integrated health system, providing real-world evidence on the prognostic value of molecular profiling beyond treat …
This study aims to evaluate the association between specific oncogenic biomarker alterations and overall survival (OS) across all stages of …
The burden of dietary risk factors in the Nordic and Baltic countries: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Nordic and Baltic Diet Collaborators. GBD 2023 Nordic and Baltic Diet Collaborators. Lancet Reg Health Eur. 2025 Nov 25;61:101543. doi: 10.1016/j.lanepe.2025.101543. eCollection 2026 Feb. Lancet Reg Health Eur. 2025. PMID: 41376666 Free PMC article.
Knowledge about the impact from unhealthy diet can inform targeted public health policies. FUNDING: Gates Foundation and Norwegian Institute of Public Health....
Knowledge about the impact from unhealthy diet can inform targeted public health policies. FUNDING: Gates Foundation and Norwegian …
White Matter Bundle Reconstruction From Single-Shell Diffusion Magnetic Resonance Imaging: Test-Retest Reliability and Predictive Capability Across Orientation Distribution Function Reconstruction Methods.
Rauland A, Meisler SL, Alexander-Bloch AF, Bagautdinova J, Baller EB, Gur RE, Gur RC, Luo AC, Moore TM, Popovych OV, Reetz K, Roalf DR, Shinohara RT, Sotardi S, Sydnor VJ, Vossough A, Eickhoff SB, Cieslak M, Satterthwaite TD. Rauland A, et al. Hum Brain Mapp. 2025 Dec 1;46(17):e70429. doi: 10.1002/hbm.70429. Hum Brain Mapp. 2025. PMID: 41376618
Associations Between Prior and Current Unhealthy Alcohol Use and Liver Morbidity Risk and Mortality Among Veterans With a History of Hepatitis C Who Have Achieved Sustained Virological Response.
Feelemyer J, Ban FK, Braithwaite RS, Bhattacharya D, Caniglia EC, Justice AC, Lim JK, Re VL, Scheidell J, Rentsch CT, Khan M. Feelemyer J, et al. J Viral Hepat. 2026 Jan;33(1):e70116. doi: 10.1111/jvh.70116. J Viral Hepat. 2026. PMID: 41376520
We sought to address this question among patients achieving sustained virologic response (SVR) after direct-acting antiviral treatment in the largest HCV health system in the United States. We extracted data on alcohol use, HCV treatment, SVR, HIV co-infection, demographic …
We sought to address this question among patients achieving sustained virologic response (SVR) after direct-acting antiviral treatment in th …
Revisiting the rural and urban divide in hospital health information technology adoption: Evidence from 2023.
Yan AS, Maguire TK, Chen J. Yan AS, et al. J Rural Health. 2025 Sep;41(4):e70100. doi: 10.1111/jrh.70100. J Rural Health. 2025. PMID: 41376270
PURPOSE: We assessed the adoption of telehealth, patient engagement (PE), and health information exchange (HIE) functionalities among hospitals in 2023, comparing adoption rates between rural and urban hospitals. ...However, overall, rural hospitals adopted an average of 0 …
PURPOSE: We assessed the adoption of telehealth, patient engagement (PE), and health information exchange (HIE) functionalities among …
Adoption and Implementation of California State Transgender and Nonbinary Protections in Los Angeles Area High Schools.
O'Brien RP, Yu K, Cederbaum JA, Ferguson L, Goldbach JT, Rhoades H, Blosnich JR. O'Brien RP, et al. J Sch Health. 2026 Jan;96(1):e70100. doi: 10.1111/josh.70100. J Sch Health. 2026. PMID: 41376144
RESULTS: Implementation of name changes, gender-neutral restrooms, private accommodations, and sexual health education varied between schools and districts. While many schools did not meet state mandates to protect TNBA student access to education, others feasibly implemen …
RESULTS: Implementation of name changes, gender-neutral restrooms, private accommodations, and sexual health education varied between …
Maternal Autoimmune Disease and the Risk of Childhood Cancer Among the Offspring: A Population-Based Cohort Study in Taiwan.
Huang YC, Hu YH, Heck JE, Weng MY, Lee PC. Huang YC, et al. Int J Rheum Dis. 2025 Dec;28(12):e70457. doi: 10.1111/1756-185x.70457. Int J Rheum Dis. 2025. PMID: 41376110
METHODS: We established a population-based cohort study using the Taiwan Maternal and Child Health Database, which links parents to their children, and connected it to the Taiwan Cancer Registry to identify cases of childhood cancer. ...Further analysis of exposure …
METHODS: We established a population-based cohort study using the Taiwan Maternal and Child Health Database, which links paren …
Protocol for a Single-Arm Pilot Clinical Trial: Developing and Evaluating a Machine Learning Opioid Prediction & Risk-Stratification E-Platform (DEMONSTRATE).
Hong JJ, Wilson DL, Nguyen K, Gellad WF, Diiulio J, Militello L, Yan S, Harle CA, Nelson D, Rosenberg EI, Schmidt S, Chang CH, Cochran G, Wu Y, Staras SAS, Kuza C, Lo-Ciganic WH. Hong JJ, et al. J Clin Med. 2025 Dec 1;14(23):8522. doi: 10.3390/jcm14238522. J Clin Med. 2025. PMID: 41375825
Methods: This single-arm study uses a pre-post implementation design with mixed-methods evaluation in 13 University of Florida Health, Gainesville, internal medicine and family medicine clinics. Eligible patients are aged 18 years, received an opioid prescription within th …
Methods: This single-arm study uses a pre-post implementation design with mixed-methods evaluation in 13 University of Florida Health …
Secure Ileal Pouch-Anal Anastomosis for Histologic Indeterminate Colitis.
M'Koma AE. M'Koma AE. J Clin Med. 2025 Nov 26;14(23):8390. doi: 10.3390/jcm14238390. J Clin Med. 2025. PMID: 41375691
Methods: In trying to resolve these diagnostic ambiguities, the current study advances our understanding by showing the expression of human alpha defensin 5 (DEFA5 alias HD5) restricted in the colon crypt mucosal lining areas, and by identifying the cells of the small inte …
Methods: In trying to resolve these diagnostic ambiguities, the current study advances our understanding by showing the expression of hum …
Burden of Hematological Malignancies in East Asia from 1990 to 2021.
Wu JF, Ho FDV, Columbres RC, Tudisco A, Jain U, Selokar A, Swami N, Jain B, Hong JH, Feliciano EJG, Ting FIL, Dee EC. Wu JF, et al. J Clin Med. 2025 Nov 26;14(23):8381. doi: 10.3390/jcm14238381. J Clin Med. 2025. PMID: 41375688
Better understanding of the burden of HMs in East Asia will allow for more targeted policy and public health efforts. Methods: Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we extracted 2021 and 1990-2021 trend estimates for total counts and a …
Better understanding of the burden of HMs in East Asia will allow for more targeted policy and public health efforts. Methods: Using …
Body Mass Index and Hemoglobin A1c Correlate with Clinical Needs After COVID-19 Vaccination in the Veterans Affairs System.
Pendse J, Jordan G, Wang B, Tenner C, Dorcely B, Ulrich RJ, Zhang K, Felson S, Jay M, Alemán JO. Pendse J, et al. J Clin Med. 2025 Nov 21;14(23):8271. doi: 10.3390/jcm14238271. J Clin Med. 2025. PMID: 41375576
Results: We identified 480,129 patients with available BMI and hemoglobin A1c data; of these, all had data available for the covariates of race, ethnicity, sex, and age, and 467,283 had data available for district as well. Adjusting for those covariates, Cox proportional h …
Results: We identified 480,129 patients with available BMI and hemoglobin A1c data; of these, all had data available for the covariates of r …
The Immune Landscape of Canine Soft Tissue Sarcomas as a Model for Human Soft Tissue Sarcomas.
Hayburn R, Chung D, Gupta A, Sills S, Wu JD, Ambrus A, Jing W, Ng J, Penaloza-MacMaster P, Selmek A, Pollack SM, Bracha S. Hayburn R, et al. Cancers (Basel). 2025 Nov 30;17(23):3860. doi: 10.3390/cancers17233860. Cancers (Basel). 2025. PMID: 41375061
This study aimed to identify the shared immune-related components of canine and human STS and to determine how these factors influence the tumor biology, progression, and prognosis. ...Gene expression profiling demonstrated similarities between canine STS and human …
This study aimed to identify the shared immune-related components of canine and human STS and to determine how these factors influenc …
Clinical and Molecular Characterization of KRAS-Mutated Renal Cell Carcinoma.
Lopez Sanmiguel A, Khandwala YS, Fengshen K, Dawidek M, Tse E, Barbakoff D, Posada Calderon L, Carlo MI, Coleman J, Russo P, Tickoo SK, Reuter VE, Reznik E, Chen YB, Hakimi AA. Lopez Sanmiguel A, et al. Cancers (Basel). 2025 Nov 29;17(23):3832. doi: 10.3390/cancers17233832. Cancers (Basel). 2025. PMID: 41375035
Performance of GAAD and GALAD Biomarker Panels for HCC Detection in Patients with MASLD or ALD Cirrhosis.
Jarrah M, Deodhar S, Quirk L, Al-Hasan M, Sharma A, Bhamra G, Terrell J, Kanwal F, Hoshida Y, Rich NE, Gopal P, Singal AG. Jarrah M, et al. Cancers (Basel). 2025 Nov 29;17(23):3835. doi: 10.3390/cancers17233835. Cancers (Basel). 2025. PMID: 41375033
GAAD and GALAD demonstrated consistently higher sensitivity than ultrasound plus AFP across subgroups by age, sex, cirrhosis etiology, and Child Pugh class. Conclusion: In this case-control study of patients with non-viral cirrhosis, GAAD and GALAD demonstrated high sensit …
GAAD and GALAD demonstrated consistently higher sensitivity than ultrasound plus AFP across subgroups by age, sex, cirrhosis etiology, and …
Targeting CXCR6 Disrupts β-Catenin Signaling and Enhances Sorafenib Response in Hepatocellular Carcinoma.
Reeves M, Chambers A, Shrestha A, Duarte S, Zarrinpar A, Malany S, Peddibhotla S. Reeves M, et al. Cancers (Basel). 2025 Nov 28;17(23):3818. doi: 10.3390/cancers17233818. Cancers (Basel). 2025. PMID: 41375019
Methods: We tested SBI-457 alone and in combination with sorafenib in SK-Hep-1 xenograft models and a panel of human HCC cell lines. Tumor burden, beta-catenin activation, and CXCR6 expression were assessed by tumor volume measurements, immunohistochemistry, Western blotti …
Methods: We tested SBI-457 alone and in combination with sorafenib in SK-Hep-1 xenograft models and a panel of human HCC cell lines. …
Tissue Microarray-Based Digital Spatial Profiling of Benign Breast Lobules and Breast Cancers: Feasibility, Biological Coherence, and Cross-Platform Benchmarks.
Sherman ME, Carter JC, Vierkant RA, Stallings-Mann M, Pacheco-Spann L, Winham SJ, Vachon CM, Wang C, Jensen MR, Troester MA, Degnim AC, Thompson EA, Kachergus J, Shi J, Radisky DC. Sherman ME, et al. Cancers (Basel). 2025 Nov 27;17(23):3797. doi: 10.3390/cancers17233797. Cancers (Basel). 2025. PMID: 41374998
Direct and Indirect Costs of Cancer in Adult Population of Poland in the Period 2021-2023.
Gąska I, Czerw A, Pajewska M, Partyka O, Charkiewicz D, Deptała A, Badowska-Kozakiewicz A, Sygit K, Dziubek I, Wojtyła-Buciora P, Drobnik J, Pobrotyn P, Waśko-Czopnik D, Sowiński T, Pobrotyn J, Wiatkowski A, Bandurska E, Ciećko W, Grochans E, Cybulska AM, Schneider-Matyka D, Rachubińska K, Czapla T, Kamecka K, Kozlowski R. Gąska I, et al. Cancers (Basel). 2025 Nov 21;17(23):3725. doi: 10.3390/cancers17233725. Cancers (Basel). 2025. PMID: 41374927
METHODS: We acquired epidemiological data from the System Analysis and Implementation Database provided Polish Ministry of Health. For estimating the direct costs of medical procedures and chemotherapy, we used statistics of homogeneous groups of patients provided by the P …
METHODS: We acquired epidemiological data from the System Analysis and Implementation Database provided Polish Ministry of Health. Fo …
Granzyme B PET Imaging Enables Detection of CAR T-Cell Therapy Response in a Human Melanoma Mouse Model.
Summer P, Bulmer N, Prabhu S, Gallon N, Larson RC, Maus MV, Mahmood U, Heidari P. Summer P, et al. Diagnostics (Basel). 2025 Nov 30;15(23):3058. doi: 10.3390/diagnostics15233058. Diagnostics (Basel). 2025. PMID: 41374439
We aim to evaluate (68)Ga-NOTA-CYT-200 PET Imaging as a molecular imaging approach to determine CAR T-cell therapy response in a human melanoma mouse model. Our goal is to provide a method to monitor CAR T-cell therapy for patients with melanoma and other solid tumors. Met …
We aim to evaluate (68)Ga-NOTA-CYT-200 PET Imaging as a molecular imaging approach to determine CAR T-cell therapy response in a human …
Dyslipidemia Assessed in Pediatric Patients: Validation of LDL-C Assessed by Friedewald Formula, Direct Assessment, and Sampson-NIH Formula.
Wawer J, Chojęta A, Swadźba J, Janiszewska M, Chojęta M, Wawer GA, Grywalska E, Milaniuk A. Wawer J, et al. Diagnostics (Basel). 2025 Nov 24;15(23):2979. doi: 10.3390/diagnostics15232979. Diagnostics (Basel). 2025. PMID: 41374360
Primary prevention of early clinical manifestations of atherosclerosis allows slowing or preventing the development of several health problems later in adult life. Objectives: The purpose of this study was the validation of LDL-C measured by the Friedewald formula, direct …
Primary prevention of early clinical manifestations of atherosclerosis allows slowing or preventing the development of several health …
Effects of Blueberry Supplementation on Depression and Anxiety Symptoms in a Rural Louisiana Population.
Venable KE, Kelley DP, Jeansonne A, Beyl R, O'Bryan S, Vatsavayi V, Jones S, Lee CC, Francis J. Venable KE, et al. Nutrients. 2025 Nov 27;17(23):3720. doi: 10.3390/nu17233720. Nutrients. 2025. PMID: 41374012 Clinical Trial.
These compounds can improve mood, cognition, and health. As such, blueberry consumption can potentially benefit those coping with depression and anxiety. In this regard, there is an unmet need for novel, effective, and accessible treatments for these conditions, particular …
These compounds can improve mood, cognition, and health. As such, blueberry consumption can potentially benefit those coping with dep …
Nutritional Modulation of the Gut Microbiome in Relation to Prenatal Lead-Induced Neurotoxicity: A Review.
Eggers S, Nagdeo KP, Sachdev K, Robinson D, Deierlein AL, Lane JM, Gennings C, Walker RW, Snetselaar L, Nidey N, O'Neal EE, Midya V. Eggers S, et al. Nutrients. 2025 Nov 26;17(23):3700. doi: 10.3390/nu17233700. Nutrients. 2025. PMID: 41373991 Review.
Despite its recognized risks, prenatal Pb exposure remains largely unregulated and poorly addressed in public health policy. Evidence suggests that the gut microbiome may mediate the neurotoxic effects of metals, offering a potential target for intervention. ...
Despite its recognized risks, prenatal Pb exposure remains largely unregulated and poorly addressed in public health policy. Evidence …
Nutrition-Based Paternal Influence on Gynecological Diseases in Female Offspring via Epigenetic Mechanisms.
Durojaye TJ, Ganguly S, Li Y, Tollefsbol TO. Durojaye TJ, et al. Nutrients. 2025 Nov 25;17(23):3690. doi: 10.3390/nu17233690. Nutrients. 2025. PMID: 41373981 Review.
Additionally, paternal overweight or obesity has been associated with increased risk of obesity in the offspring and compromised metabolic health, which may link to reproductive conditions such as infertility. Understanding the molecular mechanisms underlying non-genetic i …
Additionally, paternal overweight or obesity has been associated with increased risk of obesity in the offspring and compromised metabolic …
The Cellular Effects of Di(2-ethylhexyl) Phthalate in Non-Malignant Colonic Epithelia Involve Oxidative Stress.
Bomstein ZS, Allred KF, Allred CD. Bomstein ZS, et al. Int J Mol Sci. 2025 Dec 3;26(23):11716. doi: 10.3390/ijms262311716. Int J Mol Sci. 2025. PMID: 41373866
Human exposure to Di(2-ethylhexyl) Phthalate (DEHP) occurs through ingestion of contaminated food. ...
Human exposure to Di(2-ethylhexyl) Phthalate (DEHP) occurs through ingestion of contaminated food. ...
1,2,3-Triazolo-Bridged Click Coupling of Pinane-Based Azidodiol Enantiomers with Pyrimidine- and Purine-Based Building Blocks: Synthesis, Antiproliferative, and Antimicrobial Evaluation.
Depp D, Tari K, Szekeres A, Kovács A, Zupkó I, Szakonyi Z. Depp D, et al. Int J Mol Sci. 2025 Dec 3;26(23):11705. doi: 10.3390/ijms262311705. Int J Mol Sci. 2025. PMID: 41373851
The obtained pinane-coupled 2,4-diaminopyrimidines were screened for antiproliferative activity by MTT assay on HeLa, MD231, SiHa, MCF-7, and A2780 human cancer cell lines compared with fibroblast cells (NIH/3T3), on Gram-positive and Gram-negative pathogenic bacter …
The obtained pinane-coupled 2,4-diaminopyrimidines were screened for antiproliferative activity by MTT assay on HeLa, MD231, SiHa, MCF-7, an …
Downregulation of the CCK-B Receptor in Pancreatic Stellate Cells Blocks Molecular Proliferative Pathways and Increases Apoptosis to Decrease Pancreatic Cancer Growth In Vitro.
Ortega M, Agena E, Chen W, Cao H, Vasudevan S, Shivapurkar N, Pierobon M, Smith JP. Ortega M, et al. Int J Mol Sci. 2025 Dec 3;26(23):11699. doi: 10.3390/ijms262311699. Int J Mol Sci. 2025. PMID: 41373844
In a series of experiments, the role of the CCK-BR expression was evaluated on cell migration, proliferation, differentially expressed genes, molecular signaling pathways, and in co-culture with murine pancreatic cancer epithelial cells. Next, primary human pancreatic stel …
In a series of experiments, the role of the CCK-BR expression was evaluated on cell migration, proliferation, differentially expressed genes …
Lactobacillus murinus Induces CYP1A1 Expression and Modulates TNF-Alpha-Induced Responses in a Human Intestinal Epithelial Cell Model.
Ahmed H, Sher AA, Bell JA, Mansfield LS. Ahmed H, et al. Int J Mol Sci. 2025 Dec 2;26(23):11670. doi: 10.3390/ijms262311670. Int J Mol Sci. 2025. PMID: 41373818
This study investigates whether Lactobacillus murinus (L. murinus) attenuates tumor necrosis factor alpha (TNF-alpha)-induced pro-inflammatory responses in a human intestinal epithelial cell model of colitis by modulating the aryl hydrocarbon receptor (AHR). ...
This study investigates whether Lactobacillus murinus (L. murinus) attenuates tumor necrosis factor alpha (TNF-alpha)-induced pro-inflammato …
Role of Acetaldehyde and Dysregulated Mitophagic Lysosomal Processing in Chronic-Binge Ethanol-Induced Liver Injury.
Samuvel DJ, Foerster E, Li L, Richardson AK, Wooster PM, Lemasters JJ, Zhong Z. Samuvel DJ, et al. Int J Mol Sci. 2025 Nov 29;26(23):11608. doi: 10.3390/ijms262311608. Int J Mol Sci. 2025. PMID: 41373760
Therefore, we tested the hypothesis that chronic binge ethanol exposure disrupts mitophagic processing and stimulates release of mitochondrial damage-associated molecular patterns (mtDAMPs), thereby promoting hepatic inflammation and fibrosis after chronic binge ethanol (CBE) exp …
Therefore, we tested the hypothesis that chronic binge ethanol exposure disrupts mitophagic processing and stimulates release of mitochondri …
Prominin-1 Regulates Retinal Pigment Epithelium Homeostasis: Transcriptomic Insights into Degenerative Mechanisms.
Huo W, Yin J, Ghose P, Schafer JC, Chaum E, Bhattacharya S. Huo W, et al. Int J Mol Sci. 2025 Nov 28;26(23):11539. doi: 10.3390/ijms262311539. Int J Mol Sci. 2025. PMID: 41373691
Our study uncovers Prom1-dependent signaling networks, providing mechanistic insights into RPE degeneration relevant to both IRD and aAMD, and highlights potential therapeutic targets for preserving retinal health....
Our study uncovers Prom1-dependent signaling networks, providing mechanistic insights into RPE degeneration relevant to both IRD and aAMD, a …
Electronic Cigarette Exposure Induces Adverse Cellular Alterations in Skeletal Muscle in Male Mice Subjected to a High-Fat Diet.
Rivera JC, Espinoza-Derout J, Hasan K, Lao CJ, Wilson J, Tintut Y, Shao XM, Jordan MC, Roos KP, Liu Y, Sinha-Hikim AP, Puri V, Friedman TC. Rivera JC, et al. Int J Mol Sci. 2025 Nov 27;26(23):11491. doi: 10.3390/ijms262311491. Int J Mol Sci. 2025. PMID: 41373646
In this study, we evaluated the skeletal muscle effects of E-Cig aerosol, delivered in a manner similar to human vaping, in a mouse model of obesity induced by a high-fat diet (HFD). C57BL/6 mice, fed either a normal chow diet (NCD) or HFD, were exposed to either saline ae …
In this study, we evaluated the skeletal muscle effects of E-Cig aerosol, delivered in a manner similar to human vaping, in a mouse m …
Lipid Composition and Thermotropic Properties of Meibum of Animal Models and Humans with Meibomian Gland Dysfunction.
Butovich IA, Wojtowicz JC, Wilkerson A, Yuksel S. Butovich IA, et al. Int J Mol Sci. 2025 Nov 26;26(23):11434. doi: 10.3390/ijms262311434. Int J Mol Sci. 2025. PMID: 41373590
Here, we describe the impact of the changes in the lipid composition of meibum on its protective properties, specifically physiologically relevant thermotropic characteristics, using various mutant and wild-type animal models, and comparing them with healthy human subjects …
Here, we describe the impact of the changes in the lipid composition of meibum on its protective properties, specifically physiologically re …
Identification of Novel TAT-I24-Related Peptides with Antiviral Activities.
Harant H, Höfinger S, Grabherr R, Ruzsics Z, Hengel H. Harant H, et al. Int J Mol Sci. 2025 Nov 26;26(23):11433. doi: 10.3390/ijms262311433. Int J Mol Sci. 2025. PMID: 41373588
Selected sequences and newly designed variants of I24 were synthesized as TAT fusion peptides and tested for antiviral activity in two well-established models: baculovirus transduction of HEK293 cells and mouse cytomegalovirus (MCMV) infection of NIH/3T3 cells. Several of …
Selected sequences and newly designed variants of I24 were synthesized as TAT fusion peptides and tested for antiviral activity in two well- …
Functional Characterization of VS-186B, a Novel HDAC Inhibitor with Anticancer Activity.
Sanchez-Michael LA, Sudarshan V, Elias A, Gutierrez DA, Lopez-Saenz JA, Pena-Zacarias J, Torres GC, Varela-Ramirez A, Kumar S, Karki SS, Aguilera RJ. Sanchez-Michael LA, et al. Int J Mol Sci. 2025 Nov 24;26(23):11354. doi: 10.3390/ijms262311354. Int J Mol Sci. 2025. PMID: 41373513
Among seven compounds tested, VS-186B exhibited the highest cytotoxicity and Selective Cytotoxicity Index (SCI), particularly against the human Jurkat T-cell leukemia cell line. Flow cytometry experiments (Annexin V-FITC, ROS, JC-1, and Caspase-3/7 assays) revealed that VS …
Among seven compounds tested, VS-186B exhibited the highest cytotoxicity and Selective Cytotoxicity Index (SCI), particularly against the …
Development of Norrin-Based Protein Therapeutic for Activation of Norrin-Wnt Signaling in Human Retinal Endothelial Cells.
Mitton KP, Dailey WA, Krikor SQ, Drenser KA. Mitton KP, et al. Int J Mol Sci. 2025 Nov 24;26(23):11340. doi: 10.3390/ijms262311340. Int J Mol Sci. 2025. PMID: 41373499
We explored the feasibility of producing a recombinant protein therapeutic based on human Norrin for intravitreal injection. Norrin(K86P) production was tested using MBP fusion and non-tagged versions. FZD4 binding was evaluated by an ELISA, and the activation of AXIN2 gen …
We explored the feasibility of producing a recombinant protein therapeutic based on human Norrin for intravitreal injection. Norrin(K …
Investigating Asthma Disparities in Hispanic Communities Using Machine Learning Algorithms on the All of Us Researcher Workbench.
Jin L, Melaram R. Jin L, et al. Healthcare (Basel). 2025 Dec 4;13(23):3178. doi: 10.3390/healthcare13233178. Healthcare (Basel). 2025. PMID: 41373394
These findings highlight important associations rather than causal relationships and may inform public health efforts to address asthma disparities related to weight and healthcare accessibility among Hispanic populations....
These findings highlight important associations rather than causal relationships and may inform public health efforts to address asth …
Global Research Trends and Hotspots in Cardiac Devices: A Bibliometric and Visual Analysis.
Al Shubbar MD, Alhojailan RA, Alzahrani SA, Hobani A, Alabdulqader HH, Alharbi AA, Alotibi SA, Almuzil NS, Al Jama A. Al Shubbar MD, et al. Healthcare (Basel). 2025 Dec 2;13(23):3144. doi: 10.3390/healthcare13233144. Healthcare (Basel). 2025. PMID: 41373361 Review.
Results: The United States led in publication volume (362 papers) and citations (7198), with Emory University emerging as the most prolific institution. Heart Rhythm was the most productive journal, while Europace was the most co-cited. Kurt Stromberg was the leading autho …
Results: The United States led in publication volume (362 papers) and citations (7198), with Emory University emerging as the most prolific …
Comparison of Cost-Effectiveness and Cost-Utility of a Telerehabilitation Programme for the Management of Non-Specific Neck Pain: A Study Protocol.
Sánchez-Ferre C, Castro-Sánchez AM, Lara Palomo IC, Reche-Lorite F, de la Torre-Olivares R, Fernández-Sánchez M, Saavedra-Hernández M. Sánchez-Ferre C, et al. Healthcare (Basel). 2025 Nov 26;13(23):3076. doi: 10.3390/healthcare13233076. Healthcare (Basel). 2025. PMID: 41373293
Discussion: This study will make a significant contribution to reducing costs and improving the treatment of patients with non-specific chronic neck pain. The social perspective associated with economic evaluation will enable the investigation of indirect costs such as wor …
Discussion: This study will make a significant contribution to reducing costs and improving the treatment of patients with non-specific chro …
Psychiatric Comorbidities and Treatment Modalities in Children With Osteogenesis Imperfecta: A Systematic Review of Mental Health.
Morales JM, Villar CF, Varman B, Colombo GM, Li D, Sadek SJ, Robinson ME, Murali CN, Ayers K, Gomez J, Lee B, Sutton VR, Storch EA, Wiese AD. Morales JM, et al. Am J Med Genet A. 2025 Dec 10. doi: 10.1002/ajmga.70023. Online ahead of print. Am J Med Genet A. 2025. PMID: 41373180 Review.
Data extraction included study design, population characteristics, mental health outcomes, and treatment effectiveness, with all studies assessed for quality and bias. ...These gaps highlight an urgent need for targeted mental health studies to inform screening and …
Data extraction included study design, population characteristics, mental health outcomes, and treatment effectiveness, with all stud …
Biofilm removal capacity and titanium surface integrity in non-abrasive versus abrasive peri-implantitis cleaning interventions.
Jazaeri MS, Siddiqui DA, Tsai YC, Gabel K, Lorenzana Z, Kotsakis GA. Jazaeri MS, et al. J Periodontol. 2025 Dec 10. doi: 10.1002/jper.11371. Online ahead of print. J Periodontol. 2025. PMID: 41373104
Host tissue compatibility was evaluated by human gingival fibroblast proliferation on titanium surface post-cleaning. RESULTS: Non-contact waterjet irrigation significantly reduced viable bacterial counts by 90.9% (100-fold) on titanium surface versus abrasively cleaned an …
Host tissue compatibility was evaluated by human gingival fibroblast proliferation on titanium surface post-cleaning. RESULTS: Non-co …
"The pump is one thing… but you should walk out of the hospital with a [sensor]": Perceptions on diabetes technology from minoritized caregivers in the US.
Peña D, Medina Peñaranda R, Figg LE, Hood KK, Addala A. Peña D, et al. Diabet Med. 2025 Dec 10:e70189. doi: 10.1111/dme.70189. Online ahead of print. Diabet Med. 2025. PMID: 41373082
AIMS: Drivers of inequitable health outcomes are underexplored in minoritized youth with type 1 diabetes (T1D). In this pilot qualitative study, we recruited parents and guardians (hereafter referred to as caregivers) of youth with T1D on public insurance at Stanford Medic …
AIMS: Drivers of inequitable health outcomes are underexplored in minoritized youth with type 1 diabetes (T1D). In this pilot qualita …
Comparative efficacy of novel bioactive glass versus sodium fluoride toothpaste for dentin hypersensitivity.
Hasturk H, Boyd D, MacDonald-Parsons K, Turner-Cahill S, Seong J, West N, Doucette HJ. Hasturk H, et al. J Periodontol. 2025 Dec 10. doi: 10.1002/jper.70024. Online ahead of print. J Periodontol. 2025. PMID: 41373067
This innovative approach aligns with World Health Organization (WHO) recommendations for fluoride use and addresses unmet needs in DH management globally. Further research is warranted to explore its long-term applications in preventive and restorative dentistry. CLINICAL …
This innovative approach aligns with World Health Organization (WHO) recommendations for fluoride use and addresses unmet needs in DH …
Velocity Spectrum Imaging Using Velocity Encoding Preparation Pulses.
Hernandez-Garcia L, Vazquez AL, Noll DC. Hernandez-Garcia L, et al. Magn Reson Med. 2025 Dec 10. doi: 10.1002/mrm.70218. Online ahead of print. Magn Reson Med. 2025. PMID: 41373066
We demonstrate the technique on the brains of five human participants from whom we collected the velocity distribution along each of the three laboratory axes. RESULTS: Velocity distribution measurements on simple phantoms yielded velocity distributions consistent with the …
We demonstrate the technique on the brains of five human participants from whom we collected the velocity distribution along each of …
Creating healthy habits for Maryland preschoolers (CHAMP): a cluster-randomized controlled trial among childcare centers.
Kowalski AJ, Armstrong B, Trude ACB, Arbaiza R, Czinn A, Bellows LL, Johnson SL, Wang Y, Hager ER, Black MM. Kowalski AJ, et al. Int J Behav Nutr Phys Act. 2025 Dec 10. doi: 10.1186/s12966-025-01824-6. Online ahead of print. Int J Behav Nutr Phys Act. 2025. PMID: 41372951 Free article.
BACKGROUND: Risks for chronic health problems are embedded in preschoolers' dietary and physical activity habits. Childcare centers are a potential venue to establish healthy habits. ...Analyses adjusted for baseline differences in child age, race, and ethnicity …
BACKGROUND: Risks for chronic health problems are embedded in preschoolers' dietary and physical activity habits. Childcare centers a …
Provider perceptions and experiences integrating depression treatment into chronic healthcare services in Neno District, Malawi: a qualitative study.
Kamwiyo M, Mwale O, Mpinga K, Kayira W, Johnson I, Ruderman T, Matanje B, Kasambara K, Houde A, Isaacs R, Needham C, Wagner G, Kulisewa K, Udedi M, McBain RK. Kamwiyo M, et al. BMC Health Serv Res. 2025 Dec 10. doi: 10.1186/s12913-025-13830-2. Online ahead of print. BMC Health Serv Res. 2025. PMID: 41372945 Free article. No abstract available.
Epigenetic control of metabolic identity across cell types.
Pacheco MP, Gerard D, Mangan RJ, Chapman AR, Hecker D, Kellis M, Schulz MH, Sinkkonen L, Sauter T. Pacheco MP, et al. BMC Genomics. 2025 Dec 10. doi: 10.1186/s12864-025-12155-y. Online ahead of print. BMC Genomics. 2025. PMID: 41372842 Free article.
Analysis of these networks revealed the distribution of metabolic functionalities across human cell types and provides a compendium of human metabolic activity. This integrative approach allowed us to define, across tissues and cell types, (i) reactions that fulfil …
Analysis of these networks revealed the distribution of metabolic functionalities across human cell types and provides a compendium o …
High prevalence of multi-drug resistant H58 Salmonella Typhi and emerging fluoroquinolone resistance among febrile children in Nairobi County, Kenya.
Kavai SM, Mbae C, Mugo M, Njoroge P, Chepchirchir J, Wambui N, Anyona S, Imoli D, Ng'etich R, Kibet E, Odityo G, Mundalo S, Wairimu C, Kariuki M, Njuguna A, Wamucii E, Mbithi W, Owegi D, Muturi P, Kebenei C, Miriti H, Komen N, Kioko C, Kawira M, Kavai J, Osman R, Wakio Z, Ongadi B, Onsare R, Kering K, Kariuki S. Kavai SM, et al. BMC Infect Dis. 2025 Dec 10. doi: 10.1186/s12879-025-12317-z. Online ahead of print. BMC Infect Dis. 2025. PMID: 41372809 Free article. No abstract available.
Retrospective review of metastatic hormone receptor-positive inflammatory breast cancer patients reveals poor responses to cyclin dependent kinase 4/6 inhibition.
Nasrazadani A, Tidwell RS, Kai M, Lim B, Valero V, Tripathy D, Saleem S, Debeb BG, Lucci A, Woodward WA, Layman RM; MDACC IBC Clinic and Research Team. Nasrazadani A, et al. Breast Cancer Res. 2025 Dec 10. doi: 10.1186/s13058-025-02162-y. Online ahead of print. Breast Cancer Res. 2025. PMID: 41372771 Free article.
METHODS: Data from 58 IBC patients with metastatic HR + /HER2- IBC from a single institution were reviewed. The medians (95% confidence intervals) of overall survival (OS), PFS, and time on treatment (ToT) from the time of CDKI initiation were reported via the Kaplan-Meier …
METHODS: Data from 58 IBC patients with metastatic HR + /HER2- IBC from a single institution were reviewed. The medians (95% confiden …
Common data elements for criminal legal system involvement for people who use drugs.
Ray B, Christopher M, Saavedra LM, Cance J, Seal D, Gicquelais R, Conway C, Illei D, Beletsky L. Ray B, et al. Harm Reduct J. 2025 Dec 11;22(Suppl 1):198. doi: 10.1186/s12954-025-01362-1. Harm Reduct J. 2025. PMID: 41372754 Free article.
Interactions with policing, courts, detention facilities, and community supervision can shape health risk and disrupt access to services. ...Using input from experts and leveraging the National Institutes of Health Research on Interventio …
Interactions with policing, courts, detention facilities, and community supervision can shape health risk and disrupt access t …
Intersection of Structural Conditions that Contribute to Healthcare Access After Release from Prison: Qualitative Findings from the SCHARP Study.
Morris MA, Binswanger IA, Gleason K, Ritger C, Ford M, Blair IV, Hanratty R, Daugherty SL. Morris MA, et al. J Gen Intern Med. 2025 Dec 10. doi: 10.1007/s11606-025-10060-4. Online ahead of print. J Gen Intern Med. 2025. PMID: 41372666
BACKGROUND: People re-entering the community after prison face poor health outcomes and challenges accessing care. Structural conditions in healthcare systems may contribute to these problems. ...Sixteen community members had lived experience with incarceration; clinicians …
BACKGROUND: People re-entering the community after prison face poor health outcomes and challenges accessing care. Structural conditi …
Translational Relevance of the Genomic Landscape of KRASG12D-Mutant Colorectal and Pancreatic Cancers.
Jazieh K, Tsai J, Solomon S, Zhu M, Pedersen KS, Fernandez-Zapico ME, Xie H. Jazieh K, et al. Target Oncol. 2025 Dec 11. doi: 10.1007/s11523-025-01191-z. Online ahead of print. Target Oncol. 2025. PMID: 41372636
PATIENTS AND METHODS: This retrospective analysis utilized circulating tumor DNA data from two cohorts with advanced CRC and PDAC: a national cohort from Guardant (n = 27,497) and a Mayo Clinic cohort (n = 1434). Patients were categorized into three groups: KRAS(G12D) alon …
PATIENTS AND METHODS: This retrospective analysis utilized circulating tumor DNA data from two cohorts with advanced CRC and PDAC: a nati …
The future of algorithmic nondiscrimination compliance in the affordable care act.
La Cava WG, Cohen IG, Aysola J. La Cava WG, et al. NPJ Digit Med. 2025 Dec 10. doi: 10.1038/s41746-025-02224-7. Online ahead of print. NPJ Digit Med. 2025. PMID: 41372617 Free article. Review.
Political uncertainty around enforcement complicates long-term planning, making expanded regulatory support essential for health systems and developers alike....
Political uncertainty around enforcement complicates long-term planning, making expanded regulatory support essential for health syst …
Effect of fasting-mimicking diet on markers of autophagy and metabolic health in human subjects.
Espinoza SE, Park S, Connolly G, Qi W, Zhang N, Semwal M, Li Y, Lauzon M, Salmon AB, Hsu W, Wei M, Musi N. Espinoza SE, et al. Geroscience. 2025 Dec 11. doi: 10.1007/s11357-025-02035-4. Online ahead of print. Geroscience. 2025. PMID: 41372565
We conducted a pilot randomized clinical trial to examine the effects of the fasting-mimicking diet (FMD) on autophagic flux and metabolic health markers in healthy humans. Thirty healthy participants were randomized to two oral formulations of FMD (ProLon and FMD2) or con …
We conducted a pilot randomized clinical trial to examine the effects of the fasting-mimicking diet (FMD) on autophagic flux and metabolic …
Automated interstitial lung abnormalities detection at CT: external validation and potential recognition of traction bronchiectasis/bronchiolectasis.
Nakamura Y, Fukuda T, Aoyagi K, Kawagishi M, Ko Y, Wada N, Hino T, Hida T, Vernooij MW, Bos D, Loth DW, Ozaki M, Koga A, Bjarnadottir H, Gudmundsdottir V, Gudmundsson G, Gudnason V, Nishino M, Christiani DC, Hunninghake GM, Ishigami K, Hatabu H. Nakamura Y, et al. Jpn J Radiol. 2025 Dec 11. doi: 10.1007/s11604-025-01917-z. Online ahead of print. Jpn J Radiol. 2025. PMID: 41372552
Individual differences in behavioral effects of xylazine and opioid-xylazine mixtures in male rats.
Woodhouse KL, Li JX. Woodhouse KL, et al. Psychopharmacology (Berl). 2025 Dec 11. doi: 10.1007/s00213-025-06988-4. Online ahead of print. Psychopharmacology (Berl). 2025. PMID: 41372547
Systematic examination of pharmacological interactions between xylazine and opioids is needed to understand the disparate findings between preclinical studies and human reports. OBJECTIVES: This study examined behavioral interactions between xylazine and opioids in rats to …
Systematic examination of pharmacological interactions between xylazine and opioids is needed to understand the disparate findings between p …
Liquid biopsies across the cancer care continuum.
Landon BV, Annapragada AV, Niknafs N, Velculescu VE, Anagnostou V. Landon BV, et al. Nat Med. 2025 Dec 10. doi: 10.1038/s41591-025-04093-9. Online ahead of print. Nat Med. 2025. PMID: 41372534 Review.
Somatic evolution following cancer treatment in normal tissue.
Pich O, Ward S, Rowan A, Naceur-Lombardelli C, Shutkever O, Martinez-Ruiz C, Harries S, Hessey S, Naidu B, Brenton JD, Le Quesne J, Thomas A, Richards C, Krebs MG, Turajlic S, Jogai S, Zaccaria S, Moore D, Hiley CT; PEACE Consortium; Swanton C, Jamal-Hanjani M, McGranahan N. Pich O, et al. Nature. 2025 Dec 10. doi: 10.1038/s41586-025-09792-4. Online ahead of print. Nature. 2025. PMID: 41372419
Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma.
Zhang T, Zhao W, Wirth C, Díaz-Gay M, Yin J, Cecati M, Marchegiani F, Hoang PH, Leduc C, Baine MK, Travis WD, Sholl LM, Joubert P, Sang J, McElderry JP, Antony M, Klein A, Khandekar A, Hartman C, Rosenbaum J, Colón-Matos FJ, Miraftab M, Saha M, Lee OW, Jones KM, Caporaso NE, Wong MP, Leung KC, Hsiung CA, Chen CY, Edell ES, Santamaría JM, Schabath MB, Yendamuri SS, Manczuk M, Lissowska J, Świątkowska B, Mukeria A, Shangina O, Zaridze D, Holcatova I, Mates D, Milosavljevic S, Savic M, Bossé Y, Rothberg BEG, Christiani DC, Gaborieau V, Brennan P, Liu G, Hofman P, Homer R, Yang SR, Pesatori AC, Consonni D, Yang L, Zhu B, Shi J, Brown K, Rothman N, Chanock SJ, Alexandrov LB, Choi J, Cardelli M, Lan Q, Nowak MA, Wedge DC, Landi MT. Zhang T, et al. Nature. 2025 Dec 10. doi: 10.1038/s41586-025-09825-y. Online ahead of print. Nature. 2025. PMID: 41372401
VI-OCR: "Visually Impaired" optical character recognition pipeline for text accessibility assessment.
Gao Q, Manduchi R, Ramulu PY, Legge GE, Xiong Y. Gao Q, et al. Sci Rep. 2025 Dec 11. doi: 10.1038/s41598-025-30982-7. Online ahead of print. Sci Rep. 2025. PMID: 41372330 Free article.
In this paper, we bridge the gap between computer vision and low vision fields by introducing a text accessibility assessment pipeline called VI-OCR (short for Visually Impaired Optical Character Recognition), based on state-of-the-art OCR models. VI-OCR mimics human text …
In this paper, we bridge the gap between computer vision and low vision fields by introducing a text accessibility assessment pipeline calle …
Computational whole-body-exposome models for global precision brain health.
Ibáñez A, Duran-Aniotz C, Migeot J, Báez S, Fittipaldi S, Coronel-Oliveros C, Eyre HA, Udeh-Momoh C, Zetterberg H, Alladi S, Sandi C, Robertson IH, Franzen S, Farombi T, Montalvo Ortiz JL, Seshadri S, Court F, Valdes-Sosa P, Xu J, Yu C, Grinberg L, Lawlor B, Sachdev PS, Yaffe K, Hachinski V, Friston K, Tagliazucchi E, Santamaría-García H. Ibáñez A, et al. Nat Commun. 2025 Dec 11. doi: 10.1038/s41467-025-67448-3. Online ahead of print. Nat Commun. 2025. PMID: 41372244 Free article. Review.
However, current global research remains fragmented, dominated by limited cohorts and poorly integrated datasets that disconnect whole-body health, exposome, and brain health. Theories rarely unify brain measures with extracerebral factors or capture heterogeneity i …
However, current global research remains fragmented, dominated by limited cohorts and poorly integrated datasets that disconnect whole-body …
Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates.
Wang F, Banerjee V, Barria C, Ramirez S, Allison T, Gorski D, Evans H, Nguyen Q, Harrison D, Al-Lahham R, De Gregorio Carbonell N, Pinho M, Kaalund S, Folke J, Aznar S, Concha-Marambio L, Ishtikhar M, Mallampalli VK, Pritzkow S, Shahnawaz M, Baker ML, Serysheva I, Soto C. Wang F, et al. Nat Commun. 2025 Dec 10. doi: 10.1038/s41467-025-66146-4. Online ahead of print. Nat Commun. 2025. PMID: 41372188 Free article.
Airqtl dissects cell state-specific causal gene regulatory networks with efficient single-cell eQTL mapping.
Funk MW, Wang Y, Wang L. Funk MW, et al. Nat Commun. 2025 Dec 10. doi: 10.1038/s41467-025-66214-9. Online ahead of print. Nat Commun. 2025. PMID: 41372177 Free article.
Our results dissect the drivers of cGRN heterogeneity and underscore the value of natural genetic variations in primary human cell types for biologically relevant single-cell cGRN inference....
Our results dissect the drivers of cGRN heterogeneity and underscore the value of natural genetic variations in primary human cell ty …
Editing DNA methylation in vivo.
Pan R, Ren J, Chen X, Flores LF, Gonzalez RVL, Adonnino AA, Lofts B, Waldo J, Halmai J, Devinsky O, Fink K, Liu XS. Pan R, et al. Nat Commun. 2025 Dec 10. doi: 10.1038/s41467-025-67222-5. Online ahead of print. Nat Commun. 2025. PMID: 41372159 Free article.
Limitations in PPARalpha-dependent mitochondrial programming restrain the differentiation of human stem cell-derived beta cells.
Lietzke AC, Walker EM, Bealer E, Crumley K, King J, Stendahl AM, Zhu J, Pearson GL, Levi-D'Ancona E, Henry-Kanarek B, Davidson RK, Li J, Reck EC, Wu Y, Arnipalli M, Pham JP, Mundada L, Sidarala V, Herron TJ, Coronel MM, Pennathur S, Madsen JGS, Shea LD, Soleimanpour SA. Lietzke AC, et al. Nat Commun. 2025 Dec 10;16(1):11037. doi: 10.1038/s41467-025-66022-1. Nat Commun. 2025. PMID: 41372150 Free article.
Utilizing transcriptomic profiling, assessments of chromatin accessibility, mitochondrial phenotyping, and lipidomics analyses, we observe that SC-beta cells exhibit reduced oxidative and mitochondrial fatty acid metabolism compared to primary human islets that are related …
Utilizing transcriptomic profiling, assessments of chromatin accessibility, mitochondrial phenotyping, and lipidomics analyses, we observe t …
The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma.
Yang Q, Wang Y, Corchete Sanchez LA, Mathavarajah S, Qin Q, Wei Y, Alpert E, Whelton L, Sharma P, Strom S, Oultache I, Iafrate AJ, Pinello L, Rheinbay E, Yan C, Langenau DM. Yang Q, et al. Nat Commun. 2025 Dec 10. doi: 10.1038/s41467-025-66632-9. Online ahead of print. Nat Commun. 2025. PMID: 41372143 Free article.
Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemic.
Bents SJ, Martin ET, Stevens-Ayers T, Andrews C, Adler A, Perofsky AC, Krantz EM, Blazevic R, Kimball L, Prentice R, Hansen C, Starita L, Han P, Englund JA, Wolter N, von Gottberg A, Maake L, Moyes J, Cohen C, Boeckh M, Hay JA, Waghmare A, Viboud C. Bents SJ, et al. Nat Commun. 2025 Dec 10;16(1):11015. doi: 10.1038/s41467-025-65957-9. Nat Commun. 2025. PMID: 41372127 Free article.
Solvent-annealed triple-helix reconstituted schizophyllan hydrogels with mechanically tunable and injectable properties.
Chen L, Lu M, Guo C, Sun H, Zhang Y, Wang X, Zhang Y, Wang Z, Jiang C, Wu J, Fan Z, Sun T. Chen L, et al. Carbohydr Polym. 2026 Feb 15;374:124727. doi: 10.1016/j.carbpol.2025.124727. Epub 2025 Nov 20. Carbohydr Polym. 2026. PMID: 41371865
The resulting semi-flexible network resists small strains but shows shear-thinning behavior for facile syringe injection. In vitro studies show >95 % NIH/3 T3 viability, and in vivo subcutaneous implantation in mice elicits only transient inflammation that resolves with …
The resulting semi-flexible network resists small strains but shows shear-thinning behavior for facile syringe injection. In vitro studies s …
Pharmacological Profile and Therapeutic Evaluation of ROC-101, a Potent and Selective ROCK Inhibitor, in Arterial Hypertension and Pulmonary Fibrosis.
Mo R, Lucas S, Feng XJ, Hackett A, Skucas E, Liu KG, Kim JI, Kolahi P, Gaffney J, Spinney JJ, Knipe RS, Patel JP, Steiner MK, Elliott S, Marshall W, Hui J, Grant SN, Poyurovsky MV. Mo R, et al. Pharmacol Res. 2025 Dec 8:108062. doi: 10.1016/j.phrs.2025.108062. Online ahead of print. Pharmacol Res. 2025. PMID: 41371481
Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome.
Montellier E, Manches O, Gaucher J, Freycon C, Hoyos D, Blanchet S, Verboom M, Dutzmann CM, Coutant S, Bou J, Fin B, Olaso R, Deleuze JF, Frébourg T, Greenbaum BD, Levine AJ, Kratz CP, Bougeard G, Hainaut P. Montellier E, et al. EBioMedicine. 2025 Dec 9;123:106065. doi: 10.1016/j.ebiom.2025.106065. Online ahead of print. EBioMedicine. 2025. PMID: 41370968 Free article.
FUNDING: European Commission, Fondation MSDAvenir, BMBF, Deutsche Kinderkrebsstiftung, European Regional Development Fund, Region Normandie, NIH, Mark Foundation, and Hertz Foundation....
FUNDING: European Commission, Fondation MSDAvenir, BMBF, Deutsche Kinderkrebsstiftung, European Regional Development Fund, Region Normandie, …
Reply to Cornea-D-25-00755.
Price MO, Benetz BA, Lass JH; Diabetes Endothelial Keratoplasty Study Group. Price MO, et al. Cornea. 2025 Nov 17. doi: 10.1097/ICO.0000000000004054. Online ahead of print. Cornea. 2025. PMID: 41370845 No abstract available.
Building Pediatric Cancer Cohorts and Accessing Data Using Childhood Cancer Data Initiative Tools.
Jagu S, Guidry Auvil JM, Cunningham M, Sayoldin B, Dunn P, Burke S, Bullen C, Liu Q, Jimenez RF, Winter C, Dingerdissen H, Patel J, Otridge J, Widemann B, Kibbe W, Reaman G. Jagu S, et al. JCO Clin Cancer Inform. 2025 Dec;9:e2500217. doi: 10.1200/CCI-25-00217. Epub 2025 Dec 10. JCO Clin Cancer Inform. 2025. PMID: 41370779
PURPOSE: Data sharing is necessary to advance understanding of the etiology and biology of cancer in children, adolescents, and young adults; drive therapeutic discoveries; and improve treatment outcomes. To meet this critical need, the National Cancer Institute' …
PURPOSE: Data sharing is necessary to advance understanding of the etiology and biology of cancer in children, adolescents, and young adults …
Associations Between Physical Activity and Glaucoma: Analysis of the National Institutes of Health All of Us Research Program.
Akarapimand P, Hallaj S, Weinreb RN, Baxter SL. Akarapimand P, et al. J Glaucoma. 2026 Jan 1;35(1):34-41. doi: 10.1097/IJG.0000000000002660. Epub 2025 Oct 23. J Glaucoma. 2026. PMID: 41370653
PATIENTS AND METHODS: All subjects were adult participants in the National Institutes of Health All of Us Research Program. We defined a case cohort consisting of participants with Fitbit and electronic health record data with a diagnosis of primary op …
PATIENTS AND METHODS: All subjects were adult participants in the National Institutes of Health All of Us Research Prog …
Bone Marrow Stromal Cells Produce Two Molecular Weight Forms of Semaphorin 3C in Response to Titanium Surface Topography That Differentially Regulate BMSCs, Osteoblasts and Osteoclasts.
Deng J, Sabalewski EL, Dennis CD, Lotz EM, Cohen DJ, Schwartz Z, Boyan BD. Deng J, et al. J Biomed Mater Res A. 2025 Dec;113(12):e70005. doi: 10.1002/jbma.70005. J Biomed Mater Res A. 2025. PMID: 41370641
RNAseq analysis showed that human bone marrow stromal cells (BMSCs) express neurogenic factors, including semaphorins 3A and 3C (sema3A; sema3C) when grown on titanium substrates. ...However, sema3C did not affect macrophage polarization. Treatment of human umbilica …
RNAseq analysis showed that human bone marrow stromal cells (BMSCs) express neurogenic factors, including semaphorins 3A and 3C (sema …
Potentiation of ryanodine receptor-mediated calcium release by MAPK is responsible for epidermal transformation and carcinogenesis.
Wang P, Cleveland KH, Shahid A, Rathnayaka C, Amirrad F, Song Z, Estillore JP, Wang R, Back TG, Chen SRW, Huang Y. Wang P, et al. Proc Natl Acad Sci U S A. 2025 Dec 16;122(50):e2505055122. doi: 10.1073/pnas.2505055122. Epub 2025 Dec 10. Proc Natl Acad Sci U S A. 2025. PMID: 41370346
In vivo, UV-induced DNA damage and skin inflammation were enhanced by topical 4-CMC treatment but attenuated in the RyR2-E4872Q knock-in mice in which RyR2 activity is reduced. Human skin tissue microarray analysis confirmed spatial colocalization of phospho-ERK and RyR2 i …
In vivo, UV-induced DNA damage and skin inflammation were enhanced by topical 4-CMC treatment but attenuated in the RyR2-E4872Q knock-in mic …
A spatially informed matrix normal model for gene co-expression analysis in spatial transcriptomics studies.
Tan C, Ma Y. Tan C, et al. Nucleic Acids Res. 2025 Nov 26;53(22):gkaf1264. doi: 10.1093/nar/gkaf1264. Nucleic Acids Res. 2025. PMID: 41370198
In cross-species analyses, it detects conserved gene modules and cell type-specific pathways in the mouse and human cortex....
In cross-species analyses, it detects conserved gene modules and cell type-specific pathways in the mouse and human cortex....
Pathways and products of base excision DNA repair in Xenopus laevis eggs: contrast with human cell pathways.
Xue Z, Sutton PJ, Haley JD, Brownlee CW, Demple B. Xue Z, et al. Nucleic Acids Res. 2025 Nov 26;53(22):gkaf1326. doi: 10.1093/nar/gkaf1326. Nucleic Acids Res. 2025. PMID: 41370197
Excision upstream (5') of the lesion occurred in most of the frog BER products. In contrast, human cell (HEK293) extracts had Polbeta-dependent BER, with mostly 2-nt repair patches. Human LP-BER was driven by the Fen1 flap endonuclease, but it did not include 5' exc …
Excision upstream (5') of the lesion occurred in most of the frog BER products. In contrast, human cell (HEK293) extracts had Polbeta …
Clinical Characteristics, Management, and Hematopoietic Cell Transplantation of Patients with TLR8 Gain-of-Function.
Arnold DE, Kaviany S, Aluri J, Calvo KR, Mehta SS, Tobin JM, Schuettpelz L, Saucier N, Schmitz EG, Murguía-Favela L, Wright NAM, De Ravin SS, Rao VK, Holland SM, Bleesing J, Loughran TP, Feith DJ, Powell J, Ratan A, Warren JT, Pai SY, Bednarski JJ, Connelly JA, Cooper MA. Arnold DE, et al. Blood Adv. 2025 Dec 10:bloodadvances.2025016338. doi: 10.1182/bloodadvances.2025016338. Online ahead of print. Blood Adv. 2025. PMID: 41370196
Effects of physical activity on performance measures in older adult cancer survivors.
Brown JC, Tice AL, Goodpaster BH, Yi F, Yang S, Tejani MA. Brown JC, et al. Cancer. 2025 Dec 15;131(24):e70197. doi: 10.1002/cncr.70197. Cancer. 2025. PMID: 41370194 Free PMC article. Clinical Trial.

Randomization to physical activity, compared with health education, improved the 400-m walk speed at 6 months (0.042 m/s [95% CI, 0.017-0.066]; p < .001) and 12 months (0.036 m/s [95% CI, 0.011-0.060]; p = .004) but not 24 months (0.013 m/s [95% CI, -0.012 to 0.038]; p

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Randomization to physical activity, compared with health education, improved the 400-m walk speed at 6 months (0.042 m/s [95% CI, 0.0 …
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