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Year Number of Results
1946 3
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1948 3
1949 3
1950 3
1951 11
1952 9
1953 6
1954 12
1955 7
1956 5
1957 14
1958 14
1959 17
1960 19
1961 19
1962 23
1963 46
1964 61
1965 70
1966 180
1967 215
1968 214
1969 200
1970 209
1971 186
1972 199
1973 231
1974 295
1975 368
1976 407
1977 602
1978 981
1979 1194
1980 15686
1981 33526
1982 34551
1983 35009
1984 36720
1985 37424
1986 38598
1987 39963
1988 41076
1989 42718
1990 44830
1991 46118
1992 46704
1993 47434
1994 48928
1995 49315
1996 49503
1997 49844
1998 50835
1999 52351
2000 54931
2001 56281
2002 59369
2003 63593
2004 71255
2005 77914
2006 86503
2007 93089
2008 103219
2009 110020
2010 119403
2011 128479
2012 133065
2013 138238
2014 139605
2015 140737
2016 136142
2017 131546
2018 133807
2019 135255
2020 147725
2021 154885
2022 142619
2023 143003
2024 133894
2025 103644
2026 478

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Measuring Exposure to Opioids Using Self-Reported Medication Use Data Versus General Practitioner Prescription Records in the UK Biobank Study.
Domingues A, Zhai Y, Parat MO, Viallon V, Degenhardt L, Pearson SA, Zhou J, Sheikh M. Domingues A, et al. Pharmacoepidemiol Drug Saf. 2025 Dec;34(12):e70280. doi: 10.1002/pds.70280. Pharmacoepidemiol Drug Saf. 2025. PMID: 41355709
PURPOSE: The ongoing global increase in opioid use necessitates studies examining long-term health impacts. Prospective cohorts frequently rely on self-reported medication use data which may be subject to several types of bias compared to more objective measurements. ...
PURPOSE: The ongoing global increase in opioid use necessitates studies examining long-term health impacts. Prospective cohorts frequ …
Solitary drinking as a day-level risk factor for unique negative consequences among college students.
King SE, Waddell JT, Jan I, McDonald A, Raymond C, Corbin WR. King SE, et al. Alcohol Clin Exp Res (Hoboken). 2025 Dec 7. doi: 10.1111/acer.70216. Online ahead of print. Alcohol Clin Exp Res (Hoboken). 2025. PMID: 41355286
Two-level multilevel probit regressions with Bayesian estimation tested whether drinking context (i.e., solitary vs. social) was associated with an increased likelihood of experiencing each of eight unique negative consequences (i.e., social/interpersonal, risky beh …
Two-level multilevel probit regressions with Bayesian estimation tested whether drinking context (i.e., solitary vs. social) was asso …
Crystal structure of Methanococcus jannaschii dihydroorotase with substrate bound.
Vitali J, Nix JC, Newman HE, Colaneri MJ. Vitali J, et al. Acta Crystallogr F Struct Biol Commun. 2026 Jan 1. doi: 10.1107/S2053230X25010556. Online ahead of print. Acta Crystallogr F Struct Biol Commun. 2026. PMID: 41355244
Carbamoyl aspartate interacts with the protein in the active site in a manner similar to that observed for Escherichia coli and human dihydroorotases. However, the flexible loop (residues 140-151) adopts both conformations in the crystal, loop-out and loop-in, with the loo …
Carbamoyl aspartate interacts with the protein in the active site in a manner similar to that observed for Escherichia coli and human …
Dietary fatty acids and epigenetic aging in US adults: results from the National Health and Nutrition Examination Survey.
Bozack AK, Khodasevich D, Nwanaji-Enwerem JC, Gladish N, Shen H, Daredia S, Needham BL, Rehkopf DH, Guasch-Ferre M, Cardenas A. Bozack AK, et al. NPJ Aging. 2025 Dec 7. doi: 10.1038/s41514-025-00298-x. Online ahead of print. NPJ Aging. 2025. PMID: 41354984 Free article.
Fatty acids are involved in disease risk and aging processes. In the US National Health and Nutrition Examination Survey (1999-2002), we tested for associations of total, saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), and subtypes of dietary fatty …
Fatty acids are involved in disease risk and aging processes. In the US National Health and Nutrition Examination Survey (1999 …
Physical and Occupational Therapist Evaluations for Fall Prevention in the Emergency Department: A Geriatric ED Guidelines 2.0 Systematic Review.
Southerland LT, Curiati PK, Shih RD, Lo AX, Harper K, Tarnovsky I, Brengartner A, Ragsdale L, Raukar N, Ryer S, Hunold KM, Mowbray F, Maddow CL, Carpenter CR, Liu SW. Southerland LT, et al. Acad Emerg Med. 2025 Dec 7. doi: 10.1111/acem.70201. Online ahead of print. Acad Emerg Med. 2025. PMID: 41354970
Physical therapist (PT) and occupational therapist (OT) evaluations have been introduced into Emergency Department (ED) care to assist with fall risk evaluation and fall prevention care. An evaluation of current evidence was undertaken to inform the Geriatric ED Guidelines …
Physical therapist (PT) and occupational therapist (OT) evaluations have been introduced into Emergency Department (ED) care to assis …
Pathological mechanisms of motor dysfunction in familial Danish dementia: insights from a knock-in rat model.
Choudhury A, Yesiltepe M, Lashley T, Singh V, Minhas V, Yin T, Fernandez A, D'Adamio L, Ahn HJ. Choudhury A, et al. J Neuroinflammation. 2025 Dec 7. doi: 10.1186/s12974-025-03537-w. Online ahead of print. J Neuroinflammation. 2025. PMID: 41354963 Free article.
Our analysis revealed substantial vascular Danish amyloid (ADan) deposition in the cerebellar subpial and leptomeningeal vessels of FDD-KI rats, showing an age-related increase comparable to that observed in human FDD patients. Additionally, vascular Abeta deposits (Abeta- …
Our analysis revealed substantial vascular Danish amyloid (ADan) deposition in the cerebellar subpial and leptomeningeal vessels of FDD-KI r …
INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model.
DeSouza PA, Ishahak M, Qu X, McCornack C, Annamalai D, Mao DD, Vangipurapu R, Fu Y, Vessoni AT, Cleary RT, Han RH, Augsornworawat P, Woodiwiss T, Agovino D, Sizemore B, Kline J, Borhani-Haghighi M, Chen H, Pugazenthi S, Yano H, Wang T, Batista LFZ, Millman JR, Kim AH. DeSouza PA, et al. Nat Commun. 2025 Dec 7. doi: 10.1038/s41467-025-66371-x. Online ahead of print. Nat Commun. 2025. PMID: 41354838 Free article.
To investigate how canonical glioblastoma mutations promote functional plasticity, we have developed an isogenic human neural stem cell (NSC) model of glioblastoma by sequential addition of TERT promoter, TP53, and PDGFRA point mutations. ...Tumor cell evolution triggers s …
To investigate how canonical glioblastoma mutations promote functional plasticity, we have developed an isogenic human neural stem ce …
Persistent poverty, glycemic control and adverse COVID-19 outcomes: a retrospective study using real-world data.
Tanaka S, Williams S, Zhang L, Yi N, Garvey WT, Cherrington AL, Howell CR. Tanaka S, et al. BMC Public Health. 2025 Dec 7. doi: 10.1186/s12889-025-25774-7. Online ahead of print. BMC Public Health. 2025. PMID: 41354797 Free article.
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has highlighted the profound impact of diabetes and neighborhood environments on health outcomes. Persistent poverty areas, characterized by long-standing economic deprivation, may contribute to increased risk fo …
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has highlighted the profound impact of diabetes and neighborhood environments o …
SARS-CoV-2 testing behavior in symptomatic adults in a U.S. national cohort, 2020-2023: influence of exposure risk, susceptibility and healthcare access.
Sanborn J, Qasmieh S, Penrose K, Parcesepe A, Shen Y, Piltch-Loeb R, Nuñez J, Nash D, Robertson M. Sanborn J, et al. BMC Public Health. 2025 Dec 8. doi: 10.1186/s12889-025-25516-9. Online ahead of print. BMC Public Health. 2025. PMID: 41354779 Free article.
BACKGROUND: COVID-19 continues to circulate and cause illness, hospitalizations and death in the U.S, underscoring the importance of understanding SARS-CoV-2 testing behavior among symptomatic adults. ...METHODS: The CHASING COVID Cohort study comprises a diverse sa …
BACKGROUND: COVID-19 continues to circulate and cause illness, hospitalizations and death in the U.S, underscoring the importa …
CD44 cross-linking promotes Plasmodium falciparum invasion.
Kongsomboonvech AK, Scally SW, Le Guen Y, Valissery P, Salinas ND, Cowman AF, Tolia NH, Egan ES. Kongsomboonvech AK, et al. Nat Commun. 2025 Dec 7. doi: 10.1038/s41467-025-67030-x. Online ahead of print. Nat Commun. 2025. PMID: 41354647 Free article.
The ability of Plasmodium falciparum to invade and replicate asexually within human red blood cells (RBCs) is central to its pathogenicity. Invasion involves several host-parasite interactions, yet the required host factors remain underexplored, largely due to the intracta …
The ability of Plasmodium falciparum to invade and replicate asexually within human red blood cells (RBCs) is central to its pathogen …
Comment on "De Novo Reconstruction of 3D Human Facial Images from DNA Sequence".
Wagner JK, Claessens N, Maloney CM, Claes P. Wagner JK, et al. Adv Sci (Weinh). 2025 Dec 7:e13207. doi: 10.1002/advs.202513207. Online ahead of print. Adv Sci (Weinh). 2025. PMID: 41354633
Yet such research raises serious ethical, legal, and social challenges, as such applications are rights and safety impacting. Methodological transparency, algorithmic explainability, and contextualization of findings are essential to ensure that AI-enabled facial genetics …
Yet such research raises serious ethical, legal, and social challenges, as such applications are rights and safety impacting. Methodo …
A neutrophil-mesangial cell axis promotes glomerular injury in lupus nephritis.
Hanata N, Carmona-Rivera C, Hoffmann V, Jiang K, Manna Z, Randazzo D, Waldman MA, Hasni SA, Kaplan MJ. Hanata N, et al. Ann Rheum Dis. 2025 Dec 6:S0003-4967(25)04537-6. doi: 10.1016/j.ard.2025.11.011. Online ahead of print. Ann Rheum Dis. 2025. PMID: 41354562 Free article.
METHODS: Histology and flow cytometry were performed in NZB/W F(1) and C57/BL6 mice to evaluate neutrophil dynamics throughout LN development. Human LN kidney biopsies were analysed for NETs and neutrophil infiltration. In vitro, human MCs were stimulated with eithe …
METHODS: Histology and flow cytometry were performed in NZB/W F(1) and C57/BL6 mice to evaluate neutrophil dynamics throughout LN developmen …
Evaluating Tocilizumab in Ischemic Stroke: Findings from the SPAN Multicenter Trial.
Chauhan A, Lee EA, Patel RB, Kumskova M, Leira EC, Chauhan AK, Shi Y, Cao S, Koehler RC, Dhandapani KM, Khan MB, Kamat PK, Arbab A, Hess DC, Herman AL, Boisserand L, Sansing LH, Morais A, Jin X, Aykan S, Imai T, Ayata C, Nagarkatti KA, Lamb J, Diniz MA, Lyden PD, McCullough LD, Aronowski J. Chauhan A, et al. Neuropharmacology. 2025 Dec 5:110801. doi: 10.1016/j.neuropharm.2025.110801. Online ahead of print. Neuropharmacology. 2025. PMID: 41354124
Using the contributor role taxonomy (CRediT) as a tool in resolving authorship disputes at the NIH.
Partin K, Hosseini M. Partin K, et al. Account Res. 2025 Dec 7:2596063. doi: 10.1080/08989621.2025.2596063. Online ahead of print. Account Res. 2025. PMID: 41354046
Besides encouraging researchers to use CRediT for specification of contributions in publications, the National Institutes of Health (NIH) Intramural Research Program (IRP) has been using CRediT as a tool to investigate and resolve authorship disputes p …
Besides encouraging researchers to use CRediT for specification of contributions in publications, the National Institutes of …
MK-7602: a potent multi-stage dual-targeting antimalarial.
Favuzza P, Palandri J, de Lera Ruiz M, Bailey W, Boyce CW, Danziger A, Fawaz MV, Kelly M, Murgolo N, Robbins JA, Vavrek M, Zhao L, Lei Z, Guo Z, Reaksudsan K, Steel RWJ, Hodder AN, Ngo A, Dziekan JM, Thompson JK, Triglia T, Birkinshaw RW, Penington JS, Scally SW, Dans MG, Coyle R, Sevilleno N, Orban A, Feufack-Donfack LB, Popovici J, Lee MCS, Papenfuss A, Lowes KN, Sleebs BE, McCarthy JS, McCauley JA, Boddey JA, Olsen DB, Cowman AF. Favuzza P, et al. EBioMedicine. 2025 Dec 6;123:106061. doi: 10.1016/j.ebiom.2025.106061. Online ahead of print. EBioMedicine. 2025. PMID: 41353980 Free article.
FUNDING: This work was funded by The Wellcome Trust (109662/Z/15/Z, 202749/Z/16/Z, 219658/Z/19/Z), NHMRC (GNT1176955, GNT637406, GNT1173049), the Human Frontiers Science Program (LT0001/2022-L, JMD), Drakensberg Trust, the Victorian State Government Operational Infr …
FUNDING: This work was funded by The Wellcome Trust (109662/Z/15/Z, 202749/Z/16/Z, 219658/Z/19/Z), NHMRC (GNT1176955, GNT637406, GNT1173049) …
InCHORRRuS: Infant-Directed Communication Highlights and Organizes Repetition and Redundancy Through Rhythmic Structure.
Alviar C, Jones W, Lense M. Alviar C, et al. Ann N Y Acad Sci. 2025 Dec 7. doi: 10.1111/nyas.70147. Online ahead of print. Ann N Y Acad Sci. 2025. PMID: 41353628 Review.
Learning to successfully participate in social interactions is a monumental task for infants, whose perceptual systems are immature and communicative signals complex and hard to parse. ...In this paper, we present the InCHORRRuS framework: which considers the role of rhyth …
Learning to successfully participate in social interactions is a monumental task for infants, whose perceptual systems are immature a …
Automating expert-level medical reasoning evaluation of large language models.
Zhou S, Xie W, Li J, Zhan Z, Song M, Yang H, Espinoza C, Welton L, Mai X, Jin Y, Xu Z, Chung YH, Xing Y, Tsai MH, Schaffer E, Shi Y, Liu N, Liu Z, Zhang R. Zhou S, et al. NPJ Digit Med. 2025 Dec 6. doi: 10.1038/s41746-025-02208-7. Online ahead of print. NPJ Digit Med. 2025. PMID: 41353516 Free article.
HIV-1 Tat Protein Exposure Alters the Morphological Characteristics and Gene Expression in the Primary Mouse Cortex Endothelial Cells and Human Brain Microvascular Endothelial Cells.
Quan L, Manabe I, Muramatsu R, Zhu J. Quan L, et al. Cell Mol Neurobiol. 2025 Dec 6. doi: 10.1007/s10571-025-01640-3. Online ahead of print. Cell Mol Neurobiol. 2025. PMID: 41353488
This study determined the effects of the HIV-1 transactivator of transcription (Tat) protein on the morphological profiles and gene expression of mouse prefrontal cortex endothelial cells (ECs) and human brain microvascular endothelial cells (HBMVEC). Both mouse ECs and HB …
This study determined the effects of the HIV-1 transactivator of transcription (Tat) protein on the morphological profiles and gene expressi …
Mechanistic snapshots of lipid-linked sugar transfer.
Morgan RT, Motta S, Gil-Iturbe E, Bhattacharjee B, Anwar MT, Di Muccio G, Romagnoli A, Mishra B, Ashraf KU, Bang I, Di Marino D, Lowary TL, Quick M, Petrou VI, Stowell MHB, Nygaard R, Mancia F. Morgan RT, et al. Nat Commun. 2025 Dec 6. doi: 10.1038/s41467-025-66769-7. Online ahead of print. Nat Commun. 2025. PMID: 41353435 Free article.
VIRGO2: an enhanced gene catalog of the vaginal microbiome provides insights into its functional and ecology complexity.
France MT, Chaudry I, Rutt L, Quain M, Shirtliff B, McComb E, Maros A, Alizadeh M, Hussain FA, Elovitz MA, Relman DA, Rahman A, Brotman RM, Price JT, Kassaro MP, Holm JB, Ma B, Ravel J. France MT, et al. Nat Commun. 2025 Dec 6. doi: 10.1038/s41467-025-67136-2. Online ahead of print. Nat Commun. 2025. PMID: 41353361 Free article.
VIRGO2 is a critical resource for integrative analyses of vaginal microbial communities and their interactions with host tissues, thereby enhancing our mechanistic understanding of vaginal health and disease....
VIRGO2 is a critical resource for integrative analyses of vaginal microbial communities and their interactions with host tissues, thereby en …
Real-time neurofeedback, its neurotransmitter underpinnings, and therapeutic effects: study protocol for a randomized controlled trial in individuals at clinical high risk.
Vandewouw MM, Bauer CCC, Zhang J, Hammoud J, Greene KD, Hinds O, Wighton P, Smoller JW, Stone WS, Evins AE, Lin AP, Niznikiewicz MA, Whitfield-Gabrieli S. Vandewouw MM, et al. BMC Psychiatry. 2025 Dec 6. doi: 10.1186/s12888-025-07551-3. Online ahead of print. BMC Psychiatry. 2025. PMID: 41353354 Free article. No abstract available.
A light-induced microprotein triggers regulated intramembrane proteolysis to promote photo-sensing in a pathogenic bacterium.
Manias D, Mishra A, Winkelman JD, Chen G, Mukherjee S. Manias D, et al. Nat Commun. 2025 Dec 6. doi: 10.1038/s41467-025-66862-x. Online ahead of print. Nat Commun. 2025. PMID: 41353338 Free article.
Light represses biofilms and virulence factors through a bacteriophytochrome photoreceptor BphP and response regulator AlgB in the human pathogen Pseudomonas aeruginosa. Here, we used transposon mutagenesis screening to identify a conserved hypothetical microprotein, DimA, …
Light represses biofilms and virulence factors through a bacteriophytochrome photoreceptor BphP and response regulator AlgB in the human …
Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition.
Potvin-Jutras Z, Tremblay PL, Mohammadi H, Villeneuve S, Spreng RN, Gauthier CJ; PREVENT-AD Research Group. Potvin-Jutras Z, et al. Geroscience. 2025 Dec 6. doi: 10.1007/s11357-025-02036-3. Online ahead of print. Geroscience. 2025. PMID: 41353310
The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a marker of vascular st …
The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascul …
Just for Me! Black Cultural Pride Boxes Aiding Black Mothers in their Cultural Socialization Practices for their Preschoolers.
Edwards LL, Hughes DE, Farrise Beauvoir K, Coates EE. Edwards LL, et al. J Racial Ethn Health Disparities. 2025 Dec 6. doi: 10.1007/s40615-025-02737-7. Online ahead of print. J Racial Ethn Health Disparities. 2025. PMID: 41353305
Exposure to racism is an important risk-factor for Black children's mental health that can be combated through parents' transmission of cultural pride messages. To assist parents in enhancing these practices, we piloted a Black cultural pride box intervention, entitled Jus …
Exposure to racism is an important risk-factor for Black children's mental health that can be combated through parents' transmission …
Proteome-wide association study of prostate cancer risk across populations.
Zhong H, Zhu J, Liu S, Wu C, Wang L, Whelton SP, Marshall CH, Blaha MJ, Durda P, Guo X, Johnson CW, Lin HJ, Taylor KD, Tracy RP, Yarden RI, Manichaikul AW, Rich SS, Rotter JI, Deo R, Dubin RF, Ganz P, Wu L. Zhong H, et al. Nat Commun. 2025 Dec 6. doi: 10.1038/s41467-025-66250-5. Online ahead of print. Nat Commun. 2025. PMID: 41353205 Free article.
Systems genetics of lifespan and senescence in Drosophila melanogaster.
Aghdam MN, Unselt D, Adonay ME, Morozova TV, Carbone MA, Arya GH, Turlapati L, Shankar V, Anholt RRH, Mackay TFC. Aghdam MN, et al. BMC Biol. 2025 Dec 7. doi: 10.1186/s12915-025-02485-4. Online ahead of print. BMC Biol. 2025. PMID: 41353149 Free article.
BACKGROUND: As populations age, the number of people with age-related chronic diseases increases, causing significant social, economic and health problems. Natural variation in lifespan depends on multiple interacting genes and environmental exposures. ...These netw …
BACKGROUND: As populations age, the number of people with age-related chronic diseases increases, causing significant social, economi …
Association between the diagnosis of diet-related non-communicable diseases and the use of nutritional labeling among Mexican, Mexican American, and non-Mexican American adults: a cross-sectional study from the International Food Policy Study 2021-2022.
García-Perfecto I, Contreras-Manzano A, Quevedo KL, White CM, Vanderlee L, Davis RE, Oviedo-Solís CI, Thrasher JF, Barquera S, Hammond D, Nieto C, Fang D, Jáuregui A. García-Perfecto I, et al. BMC Public Health. 2025 Dec 6. doi: 10.1186/s12889-025-25874-4. Online ahead of print. BMC Public Health. 2025. PMID: 41353147 Free article. No abstract available.
911 calls for service and community context: associations between community safety needs and neighborhood environment.
Koenigsmark F, Gutierrez C, Martin CL. Koenigsmark F, et al. BMC Public Health. 2025 Dec 6. doi: 10.1186/s12889-025-24965-6. Online ahead of print. BMC Public Health. 2025. PMID: 41353119 Free article.
BACKGROUND: Calls for service (CFS) to 911 are one way to assess both community safety and public health needs. While an abundance of literature demonstrates that conditions within the neighborhood environment may contribute to violent- and property-related CFS, limited re …
BACKGROUND: Calls for service (CFS) to 911 are one way to assess both community safety and public health needs. While an abundance of …
Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier.
Lacabanne D, Ruprecht JJ, Sichrovsky M, Forrest LR, Leone V, Tavoulari S, Kunji ERS. Lacabanne D, et al. Trends Biochem Sci. 2025 Dec 5:S0968-0004(25)00266-X. doi: 10.1016/j.tibs.2025.11.002. Online ahead of print. Trends Biochem Sci. 2025. PMID: 41353022 Free article. Review.
The mitochondrial pyruvate carrier (MPC), of the SLC54 family of solute carriers, has a critical role in eukaryotic energy metabolism by transporting pyruvate, the end-product of glycolysis, into the mitochondrial matrix. Recently, structures of the human MPC1/MPC2 and MPC …
The mitochondrial pyruvate carrier (MPC), of the SLC54 family of solute carriers, has a critical role in eukaryotic energy metabolism by tra …
Bifunctional modulation of NMDA and opioid receptors in ketamine reinforcement and misuse: implications for substance use disorder treatment.
Levinstein MR, Schoenborn I, Manza P, Schatzberg AF, Zarate CA Jr, Bonaventura J, Michaelides M. Levinstein MR, et al. Biol Psychiatry. 2025 Dec 4:S0006-3223(25)01669-5. doi: 10.1016/j.biopsych.2025.11.021. Online ahead of print. Biol Psychiatry. 2025. PMID: 41352750 Review.
We contextualize this bifunctional NMDAR/MOR mechanism within ketamine's known efficacy for treatment of depression and other mental health conditions, including its potential for SUD treatment. We conclude that the brain mechanisms contributing to ketamine reinforcement, …
We contextualize this bifunctional NMDAR/MOR mechanism within ketamine's known efficacy for treatment of depression and other mental heal …
Intravascular imaging-guided percutaneous coronary intervention for acute myocardial infarction according to ACC/AHA lesion classification.
Lee SY, Joh HS, Kim HK, Han Kim J, Hong YJ, Ahn Y, Jeong MH, Hur SH, Kim DI, Chang K, Park HS, Bae JW, Jeong JO, Park YH, Yun KH, Yoon CH, Kim Y, Hwang JY, Kim HS, Kwon W, Shin D, Hong Choi K, Park TK, Yang JH, Song YB, Hahn JY, Choi SH, Gwon HC, Lee SH, Lee JM; KAMIR Investigators. Lee SY, et al. Rev Esp Cardiol (Engl Ed). 2025 Dec 4:S1885-5857(25)00345-7. doi: 10.1016/j.rec.2025.12.001. Online ahead of print. Rev Esp Cardiol (Engl Ed). 2025. PMID: 41352656 English, Spanish.
We identified 23 051 patients from KAMIR-V and KAMIR-NIH who underwent successful PCI for an infarct-related artery and stratified them by the ACC/AHA lesion classification. ...
We identified 23 051 patients from KAMIR-V and KAMIR-NIH who underwent successful PCI for an infarct-related artery and stratified th …
The Investigation of Vitamin D and Menstrual Cycles Trial (the inVitD Trial): A clinical trial of vitamin D supplementation on the hypothalamic-pituitary-ovarian axis.
Klawans MR, Kohrman O, Braxton Jackson W 2nd, Jackson CL, Metz CN, Wegienka G, Motsinger-Reif A, Steiner AZ, Baird DD, Sandler DP, Jukic AMZ. Klawans MR, et al. Contemp Clin Trials. 2025 Dec 4;160:108176. doi: 10.1016/j.cct.2025.108176. Online ahead of print. Contemp Clin Trials. 2025. PMID: 41352534 Free article.
At baseline participants provided information on their demographics and health history. Blood was drawn at the first clinic visit after which participants collected daily urine samples for one menstrual cycle (phase 1). ...
At baseline participants provided information on their demographics and health history. Blood was drawn at the first clinic visit aft …
Retrograde optogenetics reveals sensorimotor convergence within a corticotectal pathway of non-human primates.
Yu X, Gopal A, Inoue KI, Bohlen MO, Kuczewski GM, Sommer MA, Nienborg H, Takada M, Hikosaka O. Yu X, et al. Curr Biol. 2025 Dec 5:S0960-9822(25)01523-4. doi: 10.1016/j.cub.2025.11.021. Online ahead of print. Curr Biol. 2025. PMID: 41352350 Free article.
One key unresolved issue is whether prefrontal cortical outputs to motor-related subcortical regions carry predominantly motor commands(1) or mixed sensory-motor signals.(2)(,)(3) Retrograde optogenetics offers a powerful way to interrogate such projection-defined circuits,(4)(,) …
One key unresolved issue is whether prefrontal cortical outputs to motor-related subcortical regions carry predominantly motor commands(1) o …
Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy.
Sivadasan A, Fernyhough P, Calcutt NA, Frizzi KE, Gardner K, Hansen A, Breiner A, Zochodne DW, McInnes N, Punthakee Z, Gosselin S, Perkins BA, Bril V. Sivadasan A, et al. EBioMedicine. 2025 Dec 5;123:106055. doi: 10.1016/j.ebiom.2025.106055. Online ahead of print. EBioMedicine. 2025. PMID: 41352124 Free article.
Punch biopsies (3 mm) were collected and shipped to a centralised facility for processing and reading. The trial was approved by Health Canada (226063) and registered with ClinicalTrials.govNCT04005287. FINDINGS: In rats, topically administered 4% pirenzepine (100 mul) to …
Punch biopsies (3 mm) were collected and shipped to a centralised facility for processing and reading. The trial was approved by Health …
Inflammation contributes to trauma-induced coagulopathy by oxidation of multiple clotting factors.
Han CY, St John AE, Kim JH, Wang X, Ringgold KM, Neidig LE, Berenson R, Stern SA, White NJ. Han CY, et al. Redox Biol. 2025 Nov 30;89:103956. doi: 10.1016/j.redox.2025.103956. Online ahead of print. Redox Biol. 2025. PMID: 41351917 Free article.
Inflammation and oxidative stress play an unknown role in TIC. We examined plasma from injured human trauma patients presenting to the Emergency Department compared to healthy controls to elucidate the contribution of inflammation and oxidative stress to anticoagula …
Inflammation and oxidative stress play an unknown role in TIC. We examined plasma from injured human trauma patients presenting to th …
Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia.
Wang K, Saniei S, Poddar N, Martinez IG, Chao C, Autar S, Fiore P, Carcamo S, Sreenath M, Peplinski JH, Ries RE, Mei AH, Rahman NA, Mekerishvili L, Quijada-Álamo M, Freed G, Zhang M, Lachman K, Diaz Z, Gonzalez MM, Zhang J, Pham G, Filipescu D, Berisa M, Balestra T, Wheeler N, Reisz JA, D'Alessandro A, Puleston DJ, Bernstein E, Chipuk JE, Wunderlich M, Tasian SK, Marcellino BK, Glass IA; BDRL; Sturgeon CM, Landau DA, Chen Z, Papapetrou EP, Izzo F, Meshinchi S, Hasson D, Wagenblast E; BDRL. Wang K, et al. Cancer Discov. 2025 Dec 6:OF1-OF30. doi: 10.1158/2159-8290.CD-25-0556. Online ahead of print. Cancer Discov. 2025. PMID: 41351880
Use of a Novel Tele-Assessment Tool for the Identification of Autism in Preschool-Aged Children.
Corona LL, Weitlauf A, Wagner L, Dixon A, Foster TE, Lavanderos AM, Honaker M, Nicholson A, Stone C, Swanson A, Vehorn A, Warren Z. Corona LL, et al. J Autism Dev Disord. 2025 Dec 6. doi: 10.1007/s10803-025-07144-9. Online ahead of print. J Autism Dev Disord. 2025. PMID: 41351784
The TAP-P is a play-based instrument with varied administration and scoring procedures based on a child's language level. This study compared tele-assessment using the TAP-P to in-person autism assessment. ...
The TAP-P is a play-based instrument with varied administration and scoring procedures based on a child's language level. This study …
Placental expression of GKN1 and diminished pancreatic beta cell function during pregnancy.
Powe CE, White F, Allard C, Shook L, Edlow A, Bouchard L, Aguet F, Jacques PE, Ardlie K, Florez JC, Karumanchi SA, Hivert MF. Powe CE, et al. Diabetologia. 2025 Dec 6. doi: 10.1007/s00125-025-06623-z. Online ahead of print. Diabetologia. 2025. PMID: 41351688
DATA AND CODE AVAILABILITY: RNA-seq data are available from the Database of Genotypes and Phenotypes (dbGAP; https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs003151.v1.p1 ). Code for these analyses is available from https://github.com/labjacquespe/di …
DATA AND CODE AVAILABILITY: RNA-seq data are available from the Database of Genotypes and Phenotypes (dbGAP; https://www.ncbi.nlm.nih …
Finerenone and Cardiovascular Outcomes According to Baseline Kidney Function in Patients With Heart Failure: The FINEARTS-HF Trial.
Mc Causland FR, Chatur S, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Henderson AD, Rohwedder K, Amarante F, Brinker M, Schloemer P, Lam CSP, Ostrominski JW, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, McMurray JJV, Solomon SD. Mc Causland FR, et al. JACC Heart Fail. 2025 Dec 5:102778. doi: 10.1016/j.jchf.2025.102778. Online ahead of print. JACC Heart Fail. 2025. PMID: 41351608
Functional Connectivity Linked to Cognitive Recovery After Minor Stroke.
Commuri V, Dallasta I, Stone C, Girgenti S, Gould N, Llinas RH, Simon JZ, Marsh EB. Commuri V, et al. Ann Clin Transl Neurol. 2025 Dec 6. doi: 10.1002/acn3.70271. Online ahead of print. Ann Clin Transl Neurol. 2025. PMID: 41351547 Free article.
METHODS: Patients hospitalized with a minor ischemic stroke (NIH Stroke Scale < 10) were neurologically evaluated approximately 1 month following discharge. ...

METHODS: Patients hospitalized with a minor ischemic stroke (NIH Stroke Scale < 10) were neurologically evaluated approximately 1

…
Extracellular vesicles from Candidozyma (Candida) auris inhibit proliferation of CD4 T cells by disrupting the IL-2 axis.
Botbol Y, Alves V, Nimrichter L, Macian F, Nosanchuk JD, Zamith-Miranda D. Botbol Y, et al. J Immunol. 2025 Dec 6:vkaf302. doi: 10.1093/jimmun/vkaf302. Online ahead of print. J Immunol. 2025. PMID: 41351525
Due to the high frequency of multidrug-resistant strains and mortality rate, C. auris is considered a critical health threat by the Centers for Disease Control and Prevention and the World Health Organization. ...
Due to the high frequency of multidrug-resistant strains and mortality rate, C. auris is considered a critical health threat by the C …
Mediation of Polygenic Asthma Risk Through Gene Expression.
Natarajan R, Szczesny B, Kanchan K, Esquinca E, Boorgula MP, Chavan S, Campbell M, Lorizio W, Doumatey AP, Cruz AA, Watson H, Naureckas ET, Giles BL, Arinola G, Sogaolu O, Falade AG, Hansel NN, Olopade CO, Rotimi CN, Landis RC, Figueiredo CA, Kenny EE, Ruczinski I, Liu AH, Ober C, Taub MA, Johnson RK, Barnes KC, Wojcik GL, Mathias RA. Natarajan R, et al. Allergy. 2025 Dec 6. doi: 10.1111/all.70101. Online ahead of print. Allergy. 2025. PMID: 41351491
Self-Directed Neuroplasticity.
Tang YY, Tang R. Tang YY, et al. J Integr Neurosci. 2025 Nov 27;24(11):46733. doi: 10.31083/JIN46733. J Integr Neurosci. 2025. PMID: 41351444 Free article. No abstract available.
Design, Synthesis, Computational Modeling and Biological Evaluation of Novel N-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)cinnamamides as Potential Covalent Inhibitors for Oncology.
Cheke RS, Kharkar PS. Cheke RS, et al. Chem Biol Drug Des. 2025 Dec;106(6):e70211. doi: 10.1111/cbdd.70211. Chem Biol Drug Des. 2025. PMID: 41351338
The compounds were tested against three cancer cell lines-MDA-MB-231 (triple-negative breast cancer), A549 (non-small cell lung cancer), and U-87 MG (glioblastoma), alongside a cytotoxicity assessment on non-tumor NIH/3 T3 mouse embryonic fibroblast cell line. Compound 5k …
The compounds were tested against three cancer cell lines-MDA-MB-231 (triple-negative breast cancer), A549 (non-small cell lung cancer), and …
Trends in Gestational Weight Gain From 2007 to 2019: A Prospective Cohort Study.
Martin B, Cantonwine DE, Darrow LA, Ferguson KK, McElrath TF, Welch BM. Martin B, et al. Paediatr Perinat Epidemiol. 2025 Dec 5. doi: 10.1111/ppe.70101. Online ahead of print. Paediatr Perinat Epidemiol. 2025. PMID: 41351193
BACKGROUND: Gestational weight gain (GWG), the maternal weight gained between pre-pregnancy and delivery, is an important risk factor for adverse maternal and infant health outcomes. In 1990, the National Academy of Medicine released GWG recommendations based on pre …
BACKGROUND: Gestational weight gain (GWG), the maternal weight gained between pre-pregnancy and delivery, is an important risk factor for ad …
Development of a practice-based skills measure for community-based organizations implementing evidence-based interventions to advance equity.
Cruz JL, Rosas SR, Ramanadhan S. Cruz JL, et al. Implement Sci Commun. 2025 Dec 6. doi: 10.1186/s43058-025-00832-8. Online ahead of print. Implement Sci Commun. 2025. PMID: 41351130 Free article.
By centering practitioner perspectives and aligning with long-term health promotion goals, this measure offers a practical tool for strengthening the foundational skills necessary to address health inequities. Future research should explore its application in divers …
By centering practitioner perspectives and aligning with long-term health promotion goals, this measure offers a practical tool for s …
EnsembleAge clock: a reliable and robust epigenetic age clock service reveals epigenetic age acceleration in opioid-overdosed brains.
Anand A, Agarwal Y, Gupta T, Lin J, Ghemrawi M, Gerhard GS, Lee H. Anand A, et al. BMC Genomics. 2025 Dec 6. doi: 10.1186/s12864-025-12271-9. Online ahead of print. BMC Genomics. 2025. PMID: 41351063 Free article.
However, chronological age, the simple number of years one has lived, does not capture individual health differences, prompting the development of methods to accurately estimate biological age instead of relying on chronological age. ...
However, chronological age, the simple number of years one has lived, does not capture individual health differences, prompting the d …
Pyrethroid insecticide resistance of Aedes albopictus and Aedes aegypti (Diptera: Culicidae) across the Hawaiian Islands.
Seok S, McCollum MT, Jacobsen CM, Akbari OS, Mathias DK, Lee Y. Seok S, et al. Parasit Vectors. 2025 Dec 5. doi: 10.1186/s13071-025-07176-1. Online ahead of print. Parasit Vectors. 2025. PMID: 41351054 Free article.
BACKGROUND: Aedes albopictus (Skuse, 1894) and Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae) are invasive species in the Hawaiian Islands as well as other islands of the Pacific and serve as the primary vectors of arboviruses such as dengue virus. Despite its significance t …
BACKGROUND: Aedes albopictus (Skuse, 1894) and Aedes aegypti (Linnaeus, 1762) (Diptera: Culicidae) are invasive species in the Hawaiian Isla …
Differential microglial responses to structurally distinct alpha-synuclein polymorphs.
Chang K, Kim J, Iba M, Park JH, Beilina A, Syed ZA, Baena V, Horan-Portelance L, Cookson MR, You S, Kim C. Chang K, et al. Mol Brain. 2025 Dec 5. doi: 10.1186/s13041-025-01256-0. Online ahead of print. Mol Brain. 2025. PMID: 41351016 Free article.
Here, we examined the effects of structurally distinct alpha-synuclein polymorphs on microglial neuroinflammation. Human induced pluripotent stem cells (iPSCs)-derived microglia (iMicroglia, iMG) were treated with alpha-synuclein polymorphs including EGCG stabilized alpha- …
Here, we examined the effects of structurally distinct alpha-synuclein polymorphs on microglial neuroinflammation. Human induced plur …
20 Years in the Making: Advancing Postdoctoral Training in Translational Behavioral Oncology.
Horta M, Augusto BM, Wright KL, Jacobsen P, Gonzalez B, Brandon TH, Vadaparampil ST, Simmons VN. Horta M, et al. J Cancer Educ. 2025 Dec 6. doi: 10.1007/s13187-025-02800-1. Online ahead of print. J Cancer Educ. 2025. PMID: 41350962
The Translational Behavioral Oncology Postdoctoral Training Program at Moffitt Cancer Center, funded by the National Cancer Institute (T32CA090314), prepares postdoctoral fellows to excel in highly interdisciplinary and collaborative cancer research environments. Th …
The Translational Behavioral Oncology Postdoctoral Training Program at Moffitt Cancer Center, funded by the National Cancer Instit …
Widespread mono- and oligoadenylation direct small noncoding RNA maturation versus degradation fates.
Ocheltree C, Skrable B, Pimentel A, Nicholson-Shaw T, Lee SR, Lykke-Andersen J. Ocheltree C, et al. EMBO J. 2025 Dec 5. doi: 10.1038/s44318-025-00655-2. Online ahead of print. EMBO J. 2025. PMID: 41350938 Free article.
Small noncoding RNAs (sncRNAs) are subject to 3'-end trimming and tailing activities that impact maturation versus degradation decisions during biogenesis. To investigate the dynamics of human sncRNA 3'-end processing at a global level, we performed genome-wide 3'-end sequ …
Small noncoding RNAs (sncRNAs) are subject to 3'-end trimming and tailing activities that impact maturation versus degradation decisions dur …
Results of delayed or salvage autologous hematopoietic stem cell transplantation for multiple myeloma.
Pasvolsky O, Marcoux C, Milton DR, Haider AA, Tanner MR, Bashir Q, Srour S, Saini N, Smallbone P, Lin P, Ramdial J, Nieto Y, Mohamedi AH, Siddiqui UR, Jamil A, Tang G, Aljawai Y, Lee HC, Patel KK, Kebriaei P, Thomas SK, Orlowski RZ, Champlin RE, Shpall EJ, Qazilbash MH. Pasvolsky O, et al. Bone Marrow Transplant. 2025 Dec 5. doi: 10.1038/s41409-025-02771-3. Online ahead of print. Bone Marrow Transplant. 2025. PMID: 41350936
Probing tau citrullination in Alzheimer's disease brains and mouse models of tauopathy.
Liang H, Hunt JB Jr, Ma C, Kovalenko A, Calahatian J, Pedersen C, Liu H, Li J, Serrano M, Blazier D, Watler M, Rocha-Rangel P, Saunders C, Blair LJ, Breydo L, Nash K, Quadri Z, Kraemer B, Nelson P, Norris C, Abner EL, Uversky VN, Chaput D, Selenica MB, Lee DC. Liang H, et al. Acta Neuropathol. 2025 Dec 5;150(1):61. doi: 10.1007/s00401-025-02965-5. Acta Neuropathol. 2025. PMID: 41350808 Free PMC article.
A typology of physician input approaches to using AI chatbots for clinical decision-making.
Siden R, Kerman H, Gallo RJ, Cool JA, Hom J, Goh E, Ahuja N, Heidenreich P, Shieh L, Yang D, Chen JH, Rodman A, Holdsworth LM. Siden R, et al. NPJ Digit Med. 2025 Dec 5. doi: 10.1038/s41746-025-02184-y. Online ahead of print. NPJ Digit Med. 2025. PMID: 41350807 Free article.
We conducted semi-structured interviews with U.S. physicians on experiences using an LLM chatbot and developed a typology based on input patterns. ...
We conducted semi-structured interviews with U.S. physicians on experiences using an LLM chatbot and developed a typology base …
The virtual colorectal surgical trainer-ileal pouch-anal anastomosis simulator shows evidence of validity.
Garces-Palacios S, Desir A, Gopal K, Westergaard G, Ellis M, Demirel D, Salgado J, Fleshman JW, De S, Sankaranarayanan G. Garces-Palacios S, et al. Surg Endosc. 2025 Dec 5. doi: 10.1007/s00464-025-12406-9. Online ahead of print. Surg Endosc. 2025. PMID: 41350784
METHODS: In this IRB-approved study, general surgery residents and colorectal surgeons from our institution performed the IPAA procedure on the VCoST simulator. Nineteen task-specific metrics developed by expert consensus were included and automatically recorded by the sim …
METHODS: In this IRB-approved study, general surgery residents and colorectal surgeons from our institution performed the IPAA proced …
Integrating individualized connectome with amyloid pathology improves predictive modeling of future cognitive decline.
He H, Razlighi QR, Gazes Y, Habeck C, Stern Y; Alzheimer’s Disease Neuroimaging Initiative. He H, et al. Commun Med (Lond). 2025 Dec 5;5(1):515. doi: 10.1038/s43856-025-01170-5. Commun Med (Lond). 2025. PMID: 41350761 Free PMC article.
BACKGROUND: The deposition of amyloid-beta (Abeta) in the human brain is a hallmark of Alzheimer's disease and is associated with cognitive decline. ...
BACKGROUND: The deposition of amyloid-beta (Abeta) in the human brain is a hallmark of Alzheimer's disease and is associated with cog …
International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative.
Dodich A, Panzavolta A, Funghi G, Meli C, Festari C, Chatzikostopoulos T, Chicherio C, Clarens F, de Oliveira FF, Filardi M, Ibanez A, Invernizzi L, Lebouvier T, Logroscino G, MacPherson SE, Manca R, Marra C, Matias-Guiu JA, Montembeault M, Papagno C, Pomati S, Possenti M, Piguet O, Sacco L, Schild AK, Sollberger M, Tábuas-Pereira M, Tsatali M, Tsolaki M, van den Berg E, Cappa SF, Bertoux M, Kumfor F, Van den Stock J, Boccardi M, Welsh-Bohmer KA, Cerami C, Agosta F, Canu E, Almkvist O, Hagman G, Winblad B, Altomare D, Angioni D, Annoni JM, Beretta L, Berres M, Bessi V, Fimm I, Kilimann I, Bora E, Brioschi-Guevara A, Buchmann A, Gietl A, Bussè C, Cagnin A, Chander R, Kliegel M, Mella N, Costa A, Coulangers C, Ousset PJ, Cupidi C, Démonet JF, Didic M, Di Lorenzo F, Dubois B, Andrade AC, Fimm B, Galasko D, Girtler N, Nobili F, Pardini M, Henry J, Bourdage R, Jiskoot L, Poos J, Seelaar H, Klöppel S, Krebs C, Kukull WA, Levy R, Lima M, Luca A, Luzzi S, Matarrubia MF, Mecocci P, Pigliautile M, Menichelli A, Mitolo M, Monsch AU, Moraitou D, Novak P, Ortiz ME, Papageorgiou S, Scarmeas N, Papatriantafyllou J, Plutino A, Quaranta D, Ramakers I, Rossi S, Russo M, Sensi S, Sachdev P, Salmon D… See abstract for full author list ➔ Dodich A, et al. Alzheimers Res Ther. 2025 Dec 6. doi: 10.1186/s13195-025-01908-2. Online ahead of print. Alzheimers Res Ther. 2025. PMID: 41350737 Free article.
RESULTS: Overall, panelists recommended social cognition testing in routine diagnostic assessment to evaluate both socio-cognitive and socio-behavioral alterations. ...
RESULTS: Overall, panelists recommended social cognition testing in routine diagnostic assessment to evaluate both socio-cognitive an …
Cross-sectional evaluation of exposure to ozone, nitrogen dioxide, and particulate mass levels on circulating immune markers in women in the California Teachers Study.
Cauble EL, Kleeman MJ, Zhao Y, Franklin M, Yao M, Spielfogel ES, Benmarhnia T, Lacey JV Jr, Elkind MSV, Zhao J, Magpantay L, Martinez-Maza O, Wang SS, Epeldegui M. Cauble EL, et al. Sci Rep. 2025 Dec 5. doi: 10.1038/s41598-025-30900-x. Online ahead of print. Sci Rep. 2025. PMID: 41350622 Free article.
Exposure to ambient air pollutants, specifically ozone (O(3)), nitrogen dioxide (NO(2)), ultrafine, fine or coarse particulate matter (PM(0.1), PM(2.5), and PM(10)), has been linked to a number of adverse health outcomes, including cardiovascular disease. Changes in immune …
Exposure to ambient air pollutants, specifically ozone (O(3)), nitrogen dioxide (NO(2)), ultrafine, fine or coarse particulate matter (PM(0. …
Spontaneous refractive error, ocular biometry and age related lens changes in a population of geriatric rhesus macaques.
Ross JM, Roszak K, Ripolles-Garcia A, Yiu G, Murphy CJ, Moshiri A, Miyagi H, Strøm AR, Kim S, Park S, Casanova MI, Morse LS, Marangakis A, Chang C, Garzel LM, Roberts JA, Thomasy SM. Ross JM, et al. Sci Rep. 2025 Dec 5. doi: 10.1038/s41598-025-30581-6. Online ahead of print. Sci Rep. 2025. PMID: 41350600 Free article.
The purpose of this investigation was to determine refractive error, ocular biometry and age-related lens changes in a population of geriatric rhesus macaques (Macaca mulatta) from the California National Primate Research Center (CNPRC). Ophthalmic examination was performe …
The purpose of this investigation was to determine refractive error, ocular biometry and age-related lens changes in a population of geriatr …
Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity.
Xie G, Modak C, Usman OH, Tan RWF, Coca N, De Jesus G, Wang YJ, Thirumalai D, Li X, Irianto J. Xie G, et al. Commun Biol. 2025 Dec 5;8(1):1749. doi: 10.1038/s42003-025-09136-y. Commun Biol. 2025. PMID: 41350596 Free PMC article.
This tissue-level rotation motion is crucial for the morphogenesis of multiple epithelial systems. Here, we introduce human pancreatic ductal organoids as a model to study rotational migration. Live imaging revealed the persistent rotation of the organoids over time. ...We …
This tissue-level rotation motion is crucial for the morphogenesis of multiple epithelial systems. Here, we introduce human pancreati …
Thermo-reversible gelation of self-assembled conducting polymer colloids.
Damani VS, Xie X, Daso RE, Suman K, Ghasemi M, Xie W, Wu R, Wu Y, Chao CL, Alberto JE, Lorch CM, Yang AN, Nguyen DM, Shrestha T, Otero K, Lo CY, Pochan DJ, Gomez ED, Rivnay J, Kayser LV. Damani VS, et al. Nat Commun. 2025 Dec 5;16(1):10879. doi: 10.1038/s41467-025-66034-x. Nat Commun. 2025. PMID: 41350529 Free PMC article.
Black Mamas Matter: Maternal Leadership and COVID-19 Vaccine Decisions Among Black Women in Michigan.
Williams C 2nd, Cross FL, Lucio J, Hunt R, Ku CP, Bailey S, Marsh EE, Resnicow K. Williams C 2nd, et al. J Racial Ethn Health Disparities. 2025 Dec 5. doi: 10.1007/s40615-025-02768-0. Online ahead of print. J Racial Ethn Health Disparities. 2025. PMID: 41350500
These contemporary patterns of resistance reflect a broader continuity between COVID-19 vaccine hesitancy and ongoing distrust toward public health institutions, underscoring the need for culturally grounded engagement strategies that honor lived experience and comm …
These contemporary patterns of resistance reflect a broader continuity between COVID-19 vaccine hesitancy and ongoing distrust toward public …
Development and modeling of cardiac autonomic innervation.
Patsy M, Ge K, Khodabukus A, Bursac N. Patsy M, et al. Nat Cardiovasc Res. 2025 Dec 5. doi: 10.1038/s44161-025-00746-7. Online ahead of print. Nat Cardiovasc Res. 2025. PMID: 41350484 Review.
We highlight methods for generating functional cardiomyocytes and autonomic neurons from human pluripotent stem cells and discuss the benefits and limitations of existing in vivo and in vitro cardiac innervation models. ...
We highlight methods for generating functional cardiomyocytes and autonomic neurons from human pluripotent stem cells and discuss the …
Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia.
Stewart AE, Zachman DK, Castellano-Escuder P, Kelly LM, Zolyomi B, Aiduk MDI, Delaney CD, Lock IC, Bosc C, Bradley J, Killarney ST, Stuart JD, Grimsrud PA, Ilkayeva OR, Newgard CB, Chandel NS, Puissant A, Wood KC, Hirschey MD. Stewart AE, et al. Nat Metab. 2025 Dec 5. doi: 10.1038/s42255-025-01410-x. Online ahead of print. Nat Metab. 2025. PMID: 41350470
Host switching mutations in H5N1 influenza hemagglutinin suppress site-specific activation dynamics.
Kephart SM, Awatramani KF, Saunders MI, Croft JT, Lee KK. Kephart SM, et al. Nat Commun. 2025 Dec 5. doi: 10.1038/s41467-025-66926-y. Online ahead of print. Nat Commun. 2025. PMID: 41350454 Free article.
Increase in human H5N1 spillover infections resulting from dissemination of highly pathogenic avian influenza (HPAI) virus into bird and mammal populations raises concerns about HPAI gaining human transmissibility. ...
Increase in human H5N1 spillover infections resulting from dissemination of highly pathogenic avian influenza (HPAI) virus into bird …
Sex-Specific transcriptomic changes in adipose tissue following adult-onset disruption of growth hormone receptor.
Duran-Ortiz S, Young JA, List EO, Basu R, Walsh C, Gotte EA, Berryman DE, Kopchick JJ. Duran-Ortiz S, et al. Pituitary. 2025 Dec 5;29(1):5. doi: 10.1007/s11102-025-01603-3. Pituitary. 2025. PMID: 41350448 Free PMC article.
Reduction in growth hormone (GH) signaling throughout life is known to extend lifespan and enhance healthspan in mice, and congenital GH receptor (GHR) mutations in both mice and humans confer protection against age-related diseases such as cancer, diabetes, and cognitive decline …
Reduction in growth hormone (GH) signaling throughout life is known to extend lifespan and enhance healthspan in mice, and congenital GH rec …
7,8-Dihydroxyflavone ameliorates bone loss by regulating TRKB/AKT/FOXO3a pathway in a mouse model of alzheimer's disease.
Liu D, Li X, Shi P, Hong W, Huang J, Hou M, Ma L, Liao Q, Yang H, Fu X, Zhou H, Lu J, Liu Y, Feng X, Wang D, Zhou R. Liu D, et al. Psychopharmacology (Berl). 2025 Dec 6. doi: 10.1007/s00213-025-06957-x. Online ahead of print. Psychopharmacology (Berl). 2025. PMID: 41350438
This finding provides new ideas for the treatment strategy of AD with osteoporosis and is beneficial to the health of the elderly....
This finding provides new ideas for the treatment strategy of AD with osteoporosis and is beneficial to the health of the elderly....
If a therapy bot walks like a duck and talks like a duck then it is a medically regulated duck.
Ostermann M, Freyer O, Verhees FG, Kather JN, Gilbert S. Ostermann M, et al. NPJ Digit Med. 2025 Dec 5;8(1):741. doi: 10.1038/s41746-025-02175-z. NPJ Digit Med. 2025. PMID: 41350404 Free PMC article.
Large language models (LLMs) are increasingly used for mental health interactions, often mimicking therapeutic behaviour without regulatory oversight. ...Pragmatic regulation is essential to protect vulnerable users and maintain the credibility of digital health int …
Large language models (LLMs) are increasingly used for mental health interactions, often mimicking therapeutic behaviour without regu …
Sex, early life adversity, and negative self-evaluation shape the association between negative life events and depressive symptoms in adolescence.
Kuhlman KR, Antici EE, Dveirin H, Tran MM, Hall NA, Delacruz P, Bower JE. Kuhlman KR, et al. Sci Rep. 2025 Dec 5. doi: 10.1038/s41598-025-29337-z. Online ahead of print. Sci Rep. 2025. PMID: 41350349 Free article.
Adolescent depression is an increasing public health concern. Recent experiences of negative events are associated with an increase in depressive symptoms and onset of major depression, but how factors such as sex and early life adversity (ELA) influence this association r …
Adolescent depression is an increasing public health concern. Recent experiences of negative events are associated with an increase i …
PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias.
van der Maarel LE, Mungroo MR, Mulleners OJ, Rivaud MR, Verkerk AO, van Duijvenboden K, Tiel Groenestege FHT, Steimle JD, Fokkert L, de Gier-de Vries C, Klerk M, Boender AR, Martin JF, Jensen B, Boink GJJ, Devalla HD, Christoffels VM. van der Maarel LE, et al. Nat Commun. 2025 Dec 5. doi: 10.1038/s41467-025-66959-3. Online ahead of print. Nat Commun. 2025. PMID: 41350282 Free article.
Respective subdomain sizes and severity of sinus node dysfunction and atrial arrhythmia susceptibility align with PITX2 dosage. Ectopic PITX2c expression in human induced pluripotent stem cell-derived pacemaker cardiomyocytes causes PITX2 dosage-dependent transcriptional a …
Respective subdomain sizes and severity of sinus node dysfunction and atrial arrhythmia susceptibility align with PITX2 dosage. Ectopic PITX …
Intranasal cocaine self-administration in male mice.
Erickson KR, Quan Y, Farahbakhsh ZZ, Branthwaite HE, Song K, Kim JD, Lee JJ, Gibson-Corley KN, Kimchi EY, Siciliano CA. Erickson KR, et al. Nat Commun. 2025 Dec 5;16(1):10916. doi: 10.1038/s41467-025-65875-w. Nat Commun. 2025. PMID: 41350263 Free PMC article.
In addition to improved ease of use and face validity for modeling cocaine use disorder, this work provides an example of volitional nasal drug insufflation by a non-human animal, a behavior canonically thought to be unique to humans across compounds....
In addition to improved ease of use and face validity for modeling cocaine use disorder, this work provides an example of volitional nasal d …
Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1.
Susorov D, Miścicka A, Golovenko D, Loveland AB, Zinoviev A, Pestova TV, Korostelev AA. Susorov D, et al. Nat Commun. 2025 Dec 5. doi: 10.1038/s41467-025-66833-2. Online ahead of print. Nat Commun. 2025. PMID: 41350250 Free article.
GTPBP1 visualization provides the foundation for mapping and elucidating GTPBP1 mutations associated with human diseases....
GTPBP1 visualization provides the foundation for mapping and elucidating GTPBP1 mutations associated with human diseases....
Erratum to "The fourth-generation EGFR tyrosine kinase inhibitor BLU-945 resensitizes ABCG2-overexpressing multidrug-resistant non-small cell lung cancer cells to cytotoxic anticancer drugs" [European Journal of Pharmaceutical Sciences (2025) 107337].
Li YC, Lin BH, Murakami M, Wu YS, Hung TH, Ambudkar SV, Wu CP. Li YC, et al. Eur J Pharm Sci. 2025 Dec 4:107384. doi: 10.1016/j.ejps.2025.107384. Online ahead of print. Eur J Pharm Sci. 2025. PMID: 41350202 Free article. No abstract available.
A Randomized Controlled Trial of the Safety and Efficacy of Dronabinol for Agitation in Alzheimer's Disease.
Rosenberg PB, Amjad H, Burhanullah H, Nowrangi M, Vandrey R, Pierre MJ, Outen JD, Schultz M, Marano C, Agronin M, Wilkins JM, Harper D, Laffaye T, Reardon E, Turner K, Ozonsi R, Drury M, Nguyen A, Hasoğlu T, Cromwell J, Leoutsakos JM, Forester BP. Rosenberg PB, et al. Am J Geriatr Psychiatry. 2025 Nov 10:S1064-7481(25)00506-8. doi: 10.1016/j.jagp.2025.10.011. Online ahead of print. Am J Geriatr Psychiatry. 2025. PMID: 41350162
IMPORTANCE: Agitation in Alzheimer's disease (AD) is a great source of distress for patients and caregivers and a major public health burden. Current treatments are only modestly effective and many have safety issues including mortality risk. ...SETTING: 5 inpatient and ou …
IMPORTANCE: Agitation in Alzheimer's disease (AD) is a great source of distress for patients and caregivers and a major public health …
Artificial Intelligence for Cardiovascular Care in Action: From Learning to Implementation in Health Systems.
Biswas D, Thangaraj P, Pedroso AF, Ogunniyi MO, Maddox TM, Ahmad FS, Khera R. Biswas D, et al. JACC Adv. 2025 Nov;4(11 Pt 2):102307. doi: 10.1016/j.jacadv.2025.102307. JACC Adv. 2025. PMID: 41350104 Free article. Review.
Here, we draw examples from state-of-the-art AI applications to examine the interplay between AI and learning health systems to augment continuous measurement and feedback, and implementation science to robustly evaluate the efficacy and safety of AI interventions deployed …
Here, we draw examples from state-of-the-art AI applications to examine the interplay between AI and learning health systems to augme …
Leveraging Hybrid Natural Language Processing Techniques for Large-Scale Pulmonary Embolism Identification.
Hassan SM, Mylvaganam R, Didebulidze T, Khalid M, Nardelli P, Piazza G, San Jose Estepar R, Cuttica MJ, Johnson S, Dao N, San Jose Estepar R, Washko GR, Rahaghi FN. Hassan SM, et al. JACC Adv. 2025 Nov;4(11 Pt 2):101845. doi: 10.1016/j.jacadv.2025.101845. Epub 2025 May 21. JACC Adv. 2025. PMID: 41350101 Free article.
BACKGROUND: A critical gap persists in the diagnosis and management of pulmonary embolism (PE) despite contemporary medical advances, necessitating large-scale electronic health record analysis through hybrid natural language processing (NLP) methodologies to elucidate its …
BACKGROUND: A critical gap persists in the diagnosis and management of pulmonary embolism (PE) despite contemporary medical advances, necess …
Obstetric air transport: an assessment of quality metrics.
Dahl CM, Debbink M, Haberstock K, Pappas L, Wahi S, Metz TD, Smid MC. Dahl CM, et al. Am J Obstet Gynecol MFM. 2025 Dec;7(12):101815. doi: 10.1016/j.ajogmf.2025.101815. Am J Obstet Gynecol MFM. 2025. PMID: 41349973 No abstract available.
Use of new approach methodologies (NAMs) in epilepsy research and seizure risk assessment.
Roberts RA, Behl M, Hogberg HT, Dunayevich E, Morton M, Rockley K, Walker AL, Pierson J. Roberts RA, et al. Drug Discov Today. 2025 Dec 3:104569. doi: 10.1016/j.drudis.2025.104569. Online ahead of print. Drug Discov Today. 2025. PMID: 41349905 Free article. Review.
Specifically, recent data have shown that seizure can be profiled using an in vitro seizure liability assay (iSLA) comprising a microelectrode array (MEA) of human induced pluripotent stem cell (iPSC) neurons coupled with a human ion channel panel. ...
Specifically, recent data have shown that seizure can be profiled using an in vitro seizure liability assay (iSLA) comprising a microelectro …
In silico Drug Discovery: Bridging the Gaps in Preclinical Translation.
Markossian S, Baskir HM, Grossman AC, Chandran S, Rele S, Hall MD, Amaro RE, Tropsha A, Zakharov AV. Markossian S, et al. Drug Discov Today. 2025 Dec 3:104567. doi: 10.1016/j.drudis.2025.104567. Online ahead of print. Drug Discov Today. 2025. PMID: 41349903 No abstract available.
Harnessing the Microbiome in Cancer Immunotherapy: Regulation, Prediction, and Therapeutic Targeting.
Zarour HM, Trinchieri G. Zarour HM, et al. Annu Rev Immunol. 2025 Dec 5. doi: 10.1146/annurev-immunol-082323-114522. Online ahead of print. Annu Rev Immunol. 2025. PMID: 41349548 Review.
Humans are metaorganisms, composed of both host (human) cells and a roughly equal number of commensal microorganisms-collectively known as the microbiome-residing primarily at epithelial barrier surfaces. This review considers human cancer as a disease of the metaor …
Humans are metaorganisms, composed of both host (human) cells and a roughly equal number of commensal microorganisms-collectively kno …
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification.
Sill M, Schrimpf D, Patel A, Sturm D, Jäger N, Sievers P, Schweizer L, Banan R, Reuss D, Suwala A, Korshunov A, Stichel D, Wefers AK, Hau AC, Boldt H, Harter PN, Abdullaev Z, Benhamida J, Teichmann D, Koch A, Hench J, Frank S, Hasselblatt M, Mansouri S, Díaz de Ståhl T, Serrano J, Ecker J, Selt F, Taylor M, Ramaswamy V, Cavalli F, Berghoff AS, Bison B, Blattner-Johnson M, Buchhalter I, Buslei R, Calaminus G, Dikow N, Dohmen H, Euskirchen P, Fleischhack G, Gajjar A, Gerber NU, Gessi M, Gielen GH, Gnekow A, Gottardo NG, Haberler C, Hamelmann S, Hans V, Hansford JR, Hartmann C, Heppner FL, Driever PH, von Hoff K, Thomale UW, Tippelt S, Frühwald MC, Kramm CM, Schüller U, Schittenhelm J, Schuhmann MU, Stein M, Ketteler P, Ladanyi M, Jabado N, Jones BC, Jones C, Karajannis MA, Ketter R, Kohlhof P, Kordes U, Reinhardt A, Kölsche C, Lamszus K, Lichter P, Maas SLN, Mawrin C, Milde T, Mittelbronn M, Monoranu CM, Mueller W, Mynarek M, Northcott PA, Pajtler KW, Paulus W, Perry A, Blümcke I, Plate KH, Platten M, Preusser M, Pietsch T, Prinz M, Reifenberger G, Kristensen BW, Kool M, Hovestadt V, Ellison DW, Jacques TS, Varlet P, Etminan N, Acker T, Weller M, White CL, Witt O, Herold-Mende C, De… See abstract for full author list ➔ Sill M, et al. Cancer Cell. 2025 Dec 4:S1535-6108(25)00495-7. doi: 10.1016/j.ccell.2025.11.002. Online ahead of print. Cancer Cell. 2025. PMID: 41349541 Free article.
DNA methylation-based classification is now central to contemporary neuro-oncology, as highlighted by the World Health Organization (WHO) classification of central nervous system (CNS) tumors. We present the Heidelberg CNS Tumor Methylation Classifier version 12.8 (v12.8), …
DNA methylation-based classification is now central to contemporary neuro-oncology, as highlighted by the World Health Organization ( …
Genomic medicine year in review: 2025.
Manolio TA, Rupert A, Narula J, Bult CJ, Chisholm RL, Ginsburg GS, Hooker GW, Jarvik GP, Mensah GA, Roden DM, Rowley R, Taylor CO, Volpi S, Williams MS. Manolio TA, et al. Am J Hum Genet. 2025 Dec 4;112(12):2822-2825. doi: 10.1016/j.ajhg.2025.11.001. Am J Hum Genet. 2025. PMID: 41349511 No abstract available.
Psychometric testing of two measures of vaccination attitudes among U.S. Latine respondents.
Budd EL, De Anda S, Chaovalit P, Vu AH, Leve LD, DeGarmo DS. Budd EL, et al. Vaccine. 2025 Dec 4;71:128044. doi: 10.1016/j.vaccine.2025.128044. Online ahead of print. Vaccine. 2025. PMID: 41349445
The objective of this study is to test psychometric properties of widely used vaccine hesitancy and vaccine acceptance measures among diverse U.S. Latine populations. METHODS: We conducted a psychometric meta-analysis of 13,406 Latine survey participants between 202 …
The objective of this study is to test psychometric properties of widely used vaccine hesitancy and vaccine acceptance measures among divers …
Characterization of mechanical tissue properties in post-mortem human brain using magnetic resonance elastography.
Mojumder J, Lu YC, Diano AM, Alshareef AA, McGarry M, Bayly PV, Johnson CL, Butman JA, Pham DL. Mojumder J, et al. J Mech Behav Biomed Mater. 2025 Dec 2;175:107292. doi: 10.1016/j.jmbbm.2025.107292. Online ahead of print. J Mech Behav Biomed Mater. 2025. PMID: 41349373
Traumatic brain injury (TBI) is a serious health condition that can cause neurological dysfunction to varying degrees depending on the nature of the mechanical insult. In biomechanical studies of TBI under high loading conditions, post-mortem human subjects (PMHS), …
Traumatic brain injury (TBI) is a serious health condition that can cause neurological dysfunction to varying degrees depending on th …
MRDT-GAN: generative adversarial network with multi-scale residual dense transformer generator for low-dose CT denoising.
Guo S, Li J, Wu Y. Guo S, et al. Phys Med Biol. 2025 Dec 5. doi: 10.1088/1361-6560/ae28b0. Online ahead of print. Phys Med Biol. 2025. PMID: 41349217
MAIN RESULTS: We validate MRDT-GAN on both the NIH-AAPM-Mayo Clinic LDCT dataset and a real-world dataset. Experimental results indicate that MRDT-GAN achieves superior denoising performance compared with existing methods, effectively preserves details, enhances visual qua …
MAIN RESULTS: We validate MRDT-GAN on both the NIH-AAPM-Mayo Clinic LDCT dataset and a real-world dataset. Experimental results indic …
TP53/KRAS variant allele frequency ratio predicts advanced disease in mucin-producing cystic neoplasms of the pancreas.
Lin MT, Afghani E, Canto MI, Zhu J, Ali SZ, Wood LD, He J, Lafaro KJ, Hruban RH, Eshleman JR. Lin MT, et al. Am J Clin Pathol. 2025 Dec 5:aqaf133. doi: 10.1093/ajcp/aqaf133. Online ahead of print. Am J Clin Pathol. 2025. PMID: 41348949
OBJECTIVE: To identify molecular markers that predict advanced disease in mucin-producing cystic neoplasms of the pancreas. METHODS: In this single-institution study, 454 pancreatic cystic fluid specimens were examined by a clinical next-generation sequencing assay. ...
OBJECTIVE: To identify molecular markers that predict advanced disease in mucin-producing cystic neoplasms of the pancreas. METHODS: In this …
The Vagus Connection: Exploring the Neurobiology of Brain-Gut Communication.
Xing T, Ozkaya KS, Nassrallah Z, Travagli RA. Xing T, et al. J Neurophysiol. 2025 Dec 5. doi: 10.1152/jn.00516.2024. Online ahead of print. J Neurophysiol. 2025. PMID: 41348765 Free article. Review.
In this context, vagal nerve stimulation emerges as a promising therapeutic approach, enhancing gut health and cognitive function through neuroprotection and inflammation reduction. These findings underscore the vital gut-brain connection in the treatment of neurological d …
In this context, vagal nerve stimulation emerges as a promising therapeutic approach, enhancing gut health and cognitive function thr …
Synergistic delivery of 5-FU and thymoquinone via biogenic CaCO3 NPs in hyperglycemia-linked colorectal cancer cell.
Ganasan PK, Ismail N, Razis AFA, Abu Bakar MZB, Chan KW. Ganasan PK, et al. Ther Deliv. 2025 Dec 5:1-16. doi: 10.1080/20415990.2025.2594305. Online ahead of print. Ther Deliv. 2025. PMID: 41348589
Drug release studies assessed pH-responsive behavior, while biocompatibility was evaluated on NIH/3T3 cells. Cytotoxicity and cell cycle analyses were conducted on HT-29 cells under glycemic and hyperglycemic conditions. ...Improved biocompatibility and reduced toxicity we …
Drug release studies assessed pH-responsive behavior, while biocompatibility was evaluated on NIH/3T3 cells. Cytotoxicity and cell cy …
Nirsevimab Effectiveness Against Intensive Care Unit Admission for Respiratory Syncytial Virus in Infants - 24 States, December 2024-April 2025.
Zambrano LD, Simeone RM, Newhams MM, Payne AB, Halasa NB, Orzel-Lockwood AO, Calixte JM, Kamidani S, Crandall H, Cameron MA, Schuster JE, Maddux AB, Chiotos K, Irby K, Shein SL, Staat MA, Martin LM, Bhumbra SS, Nofziger RA, Chauhan JC, Zerr DM, Gertz SJ, Guzman-Cottrill JA, Kong M, Hume JR, Coates BM, Michelson KN, Levy ER, Bradford TT, Schwartz SP, Walker TC, Stockwell MS, Biggs A, Hogan AH, Lindsey K, Campbell AP, Randolph AG; Overcoming RSV Investigators. Zambrano LD, et al. MMWR Morb Mortal Wkly Rep. 2025 Nov 20;74(37):580-588. doi: 10.15585/mmwr.mm7437a1. MMWR Morb Mortal Wkly Rep. 2025. PMID: 41348586 Free article.
Effects of acidosis and inorganic phosphate on Ca2+ sensitivity of young and older adult skeletal muscle fibers.
Teigen LE, Zepeda CS, Dobrzycki I, Hunter SK, Fitts RH, Sundberg CW. Teigen LE, et al. Am J Physiol Cell Physiol. 2025 Dec 5. doi: 10.1152/ajpcell.00445.2025. Online ahead of print. Am J Physiol Cell Physiol. 2025. PMID: 41348575 Free article.
Elevated H(+) and P(i) shifted the force-pCa relationship to the right, confirming non-human studies that these metabolites contribute to fatigue by depressing the sensitivity of the myofilaments to Ca(2+). ...
Elevated H(+) and P(i) shifted the force-pCa relationship to the right, confirming non-human studies that these metabolites contribut …
Sex differences in BNST signaling and BNST CRF in fear processing.
Hon OJ, Neira S, Flanigan ME, Roland AV, Caira CM, Sides T, D'Ambrosio SL, Lee SI, Simpson Y, Buccini MC, Machinski S, Yu W, Boyt KM, Kash TL. Hon OJ, et al. Elife. 2025 Dec 5;12:RP89189. doi: 10.7554/eLife.89189. Elife. 2025. PMID: 41348565 Free PMC article.
Biliary NF-κB-Inducing Kinase Promotes Ductular Reaction, Inflammation, and Fibrosis and Impedes Liver Disease Resolution.
Wang Y, Nikooie R, Kang Q, Rui L. Wang Y, et al. FASEB J. 2025 Dec 15;39(23):e71318. doi: 10.1096/fj.202502014RRR. FASEB J. 2025. PMID: 41348430 Free PMC article.
In a separate cohort, mice were allowed a 2-week recovery period following 4 weeks of TAA administration. NIK was also ablated in human HuCC-T1 cholangiocyte cultures (HuCC-T1(NIK-/-)), and either wild-type NIK or the NIK(G885R) mutant (defective in activating IKKalpha) wa …
In a separate cohort, mice were allowed a 2-week recovery period following 4 weeks of TAA administration. NIK was also ablated in human …
Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza.
Zhang Q, Conrad TS, Moncada-Velez M, Jiang K, Cupic A, Eaton J, Hutchinson K, Gervais A, Chen R, Puel A, Bastard P, Cobat A, Sokol T, Langlois RA, Miorin L, García-Sastre A, Vanchiere JA, Casanova JL. Zhang Q, et al. J Exp Med. 2026 Mar 2;223(3):e20251962. doi: 10.1084/jem.20251962. Epub 2025 Dec 5. J Exp Med. 2026. PMID: 41348320 Free PMC article.
Avian influenza A virus (IAV) H5N1 is an emerging threat of human pandemic. We describe a 71-year-old man who died of H5N1 pneumonia in Louisiana and whose blood contained autoantibodies neutralizing type I IFNs (AAN-I-IFNs), including the 12 IFN-alpha subtypes (1-10 ng/ml …
Avian influenza A virus (IAV) H5N1 is an emerging threat of human pandemic. We describe a 71-year-old man who died of H5N1 pneumonia …
Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis.
Gervais A, Marchal A, Boucherit S, Abi Haidar A, Bizien L, Yalcinkaya A, Sandström E, Kong XF, Jacquemin E, Bernard O, Debray D, Lacaille F, Ichai P, Arikan C, Javouhey E, Roquelaure B, Gottrand F, Trespidi F, Codullo V, Cavagna L, Schleinitz N, Bousfiha M, Amenzoui N, Bousfiha AA, Jørgensen SE, Mørk N, Mogensen TH, Bastard P, Puel A, Borghesi A, Rule JA, Lee WM, Landegren N, Cobat A, Casanova JL, Jouanguy E. Gervais A, et al. J Exp Med. 2026 Mar 2;223(3):e20251760. doi: 10.1084/jem.20251760. Epub 2025 Dec 5. J Exp Med. 2026. PMID: 41348319 Free PMC article.
Factors associated with receipt of surveillance breast MRI among racially and ethnically diverse women with operable breast cancer.
Kakani P, Ro V, McGuinness JE, Michel A, Crew KD. Kakani P, et al. Breast Cancer Res Treat. 2025 Dec 5;215(1):27. doi: 10.1007/s10549-025-07838-9. Breast Cancer Res Treat. 2025. PMID: 41348256
We collected demographic and clinical data from the electronic health record. The primary endpoint was receipt of surveillance breast MRI > 1 year after diagnosis. ...CONCLUSION: Receipt of breast MRI among breast cancer survivors differed by race, ethnicity, and …
We collected demographic and clinical data from the electronic health record. The primary endpoint was receipt of surveillance breast …
Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect.
Rhodehouse K, Zitzmann C, Ravi M, Armstrong C, Moskovljevic M, Moore HP, Schill C, Fray EJ, Kumar MR, Penney T, Krzykwa C, Stauss MR, Wiseman RW, O'Connor DH, Fennessey CM, Keele BF, Lifson JD, Ribeiro RM, Perelson AS, Hoxie JA, Maness NJ, Siliciano JD, Siliciano RF. Rhodehouse K, et al. J Exp Med. 2026 Feb 2;223(2):e20251172. doi: 10.1084/jem.20251172. Epub 2025 Dec 5. J Exp Med. 2026. PMID: 41348110 Free PMC article.
Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue.
Strober JW, Ter Horst KW, Sung D, Jongejan A, Slusher AL, Gassaway BM, Tarabra E, Paulo JA, Shuken SR, Gygi SP, Santoro N, Caprio S, Serlie MJ, Bogan JS, Vatner DF. Strober JW, et al. Diabetes. 2025 Dec 5:db250488. doi: 10.2337/db25-0488. Online ahead of print. Diabetes. 2025. PMID: 41347935
To determine which defects in WAT insulin signaling are associated with human IR, WAT was obtained from three cohorts of patients with obesity. In a bariatric surgery cohort (RESOLVE), subcutaneous WAT (n = 24) was collected before and after weight loss, and RNA sequencing …
To determine which defects in WAT insulin signaling are associated with human IR, WAT was obtained from three cohorts of patients wit …
Mapping the factors of loneliness in older adults: the role of employment and work activity - a scoping review.
Domosławska-Żylińska K, Łopatek M, Olejniczak D. Domosławska-Żylińska K, et al. Int J Occup Med Environ Health. 2025 Dec 5:214240. doi: 10.13075/ijomeh.1896.02722. Online ahead of print. Int J Occup Med Environ Health. 2025. PMID: 41347770 Free article. Review.
Loneliness and social isolation are increasingly recognized as major public health challenges, particularly among older adults. ...The most numerous were health-related and sociocultural factors. Employment and social engagement played a particularly i …
Loneliness and social isolation are increasingly recognized as major public health challenges, particularly among older adults …
Expanding Our View of Drosophila Centrioles.
Burns E, Amoiroglou A, Fagerstrom CJ, Ryniawec JM, Lee L, Runyan RK, Rosin LF, Rogers GC, Rusan N. Burns E, et al. J Cell Sci. 2025 Dec 5:jcs.264338. doi: 10.1242/jcs.264338. Online ahead of print. J Cell Sci. 2025. PMID: 41347334
Alginate-gelatin-carboxymethylcellulose bioink designing and bioprinting to improve fibroblast cell niche.
Kalhori D, Goharpey F, Solati-Hashjin M. Kalhori D, et al. J Biomater Sci Polym Ed. 2025 Dec 5:1-21. doi: 10.1080/09205063.2025.2592730. Online ahead of print. J Biomater Sci Polym Ed. 2025. PMID: 41347280
Among these, the D-4 formulation exhibited the highest compressive modulus and shear-thinning properties. NIH-3T3 fibroblasts were incorporated into each bioink formulation to assess cell viability, attachment, and proliferation. ...
Among these, the D-4 formulation exhibited the highest compressive modulus and shear-thinning properties. NIH-3T3 fibroblasts were in …
Strain-specific tropism and transcriptional responses of enterovirus D68 infection in human spinal cord organoids.
Dábilla N, Maya S, McNinch C, Eddens T, Dolan PT, Freeman MC. Dábilla N, et al. Front Microbiol. 2025 Nov 19;16:1698639. doi: 10.3389/fmicb.2025.1698639. eCollection 2025. Front Microbiol. 2025. PMID: 41347238 Free PMC article.
To investigate the cellular tropism and infection dynamics of EV-D68, we profiled naive and EV-D68-infected human spinal cord organoids (hSCOs) derived from induced pluripotent stem cells (iPSCs) using single-cell RNA sequencing (scRNA-seq). ...
To investigate the cellular tropism and infection dynamics of EV-D68, we profiled naive and EV-D68-infected human spinal cord organoi …
Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Gulf Cooperation Council countries (2010-2025): a scoping review.
Briki A, Alkhatib N, Aloba B, Verma S, Nassar R, Everett D, Ehricht R, Monecke S, Senok A. Briki A, et al. Front Microbiol. 2025 Nov 19;16:1714252. doi: 10.3389/fmicb.2025.1714252. eCollection 2025. Front Microbiol. 2025. PMID: 41347236 Free PMC article. Review.
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a global public health concern, including within the Gulf Cooperation Council (GCC). As an opportunistic pathogen, MRSA poses a threat to hospitalized patients, and to the wider community. ...METHODS: A syst …
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a global public health concern, including within the Gulf Cooperati …
Differential Molecular Transcriptomics and Underlying Biological Pathways between Smokers Lung Cancer (Small Cell Lung Carcinoma) in Comparison to Healthy Human Lung Cells.
Lake B, Banerjee A, Cuffee J, Banerjee N, Armstrong E, Banerjee S, Blount C, Hunter C, El-Hashash A, Rawat K, Adedeji D, Ghosh S, Mondal T, Abedin Z, Banerjee HN. Lake B, et al. Comput Mol Biosci. 2025 Jun;15(2):19-36. doi: 10.4236/cmb.2025.152002. Epub 2025 Jun 26. Comput Mol Biosci. 2025. PMID: 41347211 Free PMC article.
Cancer is a public health crisis affecting approximately 19.3 million globally annually. Lung cancer has the highest percentage of incidence and is responsible for 27% of cancer-related deaths. ...
Cancer is a public health crisis affecting approximately 19.3 million globally annually. Lung cancer has the highest percentage of in …
Inborn errors of immunity: Manifestation, treatment, and outcome-an ESID registry 1994-2024 report on 30,628 patients.
Kindle G, Alligon M, Albert MH, Buckland M, Edgar JD, Gathmann B, Ghosh S, Gkantaras A, Nieters A, Pignata C, Robinson PN, Rusch S, Schuetz C, Sharapova S, Shillitoe B, Candotti F, Cant AJ, Casanova JL, Etzioni A, Fischer A, Meyts I, Notarangelo LD, Pergent M, Smith CIE; ESID Registry Working Party; Hammarström L, Grimbacher B, Seppänen MRJ, Mahlaoui N, Ehl S, Seidel MG. Kindle G, et al. J Hum Immun. 2025 Sep;1(3):e20250007. doi: 10.70962/jhi.20250007. Epub 2025 Jul 17. J Hum Immun. 2025. PMID: 41347188 Free PMC article.
Excited-State Energy Decomposition Analysis.
Gao J, Liu C, Chen K. Gao J, et al. Annu Rep Comput Chem. 2025;21:1-22. doi: 10.1016/bs.arcc.2025.10.003. Epub 2025 Nov 19. Annu Rep Comput Chem. 2025. PMID: 41347144 Free PMC article.
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