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Page 1
Charged molecular glue discovery enabled by targeted degron display.
Zhuang Z, Byun WS, Chrustowicz J, Kozicka Z, Li VL, Abeja DM, Donovan KA, Sepic S, You I, Słabicki M, Fischer ES, Hinshaw SM, Ebert BL, Schulman BA, Gray NS. Zhuang Z, et al. Nat Chem Biol. 2026 Apr 6. doi: 10.1038/s41589-026-02182-5. Online ahead of print. Nat Chem Biol. 2026. PMID: 41942733
Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas.
St Laurent JD, Xu GD, Ying AW, Gokbayrak B, Patil A, Paulo JA, Cervantes KS, Chen S, Feng WW, Sankar A, Samé Guerra DD, Qi J, Neel DS, Hornick JL, Kolin DL, Gygi SP, Hunstman DG, Wang Y, Kadoch C. St Laurent JD, et al. Nat Genet. 2025 Nov;57(11):2743-2755. doi: 10.1038/s41588-025-02333-9. Epub 2025 Oct 20. Nat Genet. 2025. PMID: 41116019
Rare variants in BMAL1 are associated with a neurodevelopmental syndrome.
Cuddapah VA, Chen D, Cho B, Moore R, Suri M, Safraou H, Tran-Mau-Them F, Wilson A, Odgis J, Rehman AU, Saunders C, Ganesan S, Jobanputra V, Scherer SW, Helbig I, Sehgal A. Cuddapah VA, et al. Proc Natl Acad Sci U S A. 2025 Aug 5;122(31):e2427085122. doi: 10.1073/pnas.2427085122. Epub 2025 Jul 28. Proc Natl Acad Sci U S A. 2025. PMID: 40720646 Free PMC article.
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA. Scott DC, et al. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. Nat Commun. 2024. PMID: 39396041 Free PMC article.
Single-shot 20-fold expansion microscopy.
Wang S, Shin TW, Yoder HB 2nd, McMillan RB, Su H, Liu Y, Zhang C, Leung KS, Yin P, Kiessling LL, Boyden ES. Wang S, et al. Nat Methods. 2024 Nov;21(11):2128-2134. doi: 10.1038/s41592-024-02454-9. Epub 2024 Oct 11. Nat Methods. 2024. PMID: 39394503 Free PMC article.