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Page 1
Feasibility and signals of efficacy of the Type 1 Diabetes Education and Support (T1DES) intervention to improve diabetes distress and glycemic levels among Black young adults with type 1 diabetes compared to standard diabetes education: study protocol for a randomized pilot trial.
Davis TL, McCracken C, Fisher L, Graetz I, Barzilay J, Vellanki P, Haw JS, Gonzalez Paz L, Wolf R, Crawford M, Wright M, Bock F, Sekar S. Davis TL, et al. Pilot Feasibility Stud. 2026 Apr 1. doi: 10.1186/s40814-026-01776-z. Online ahead of print. Pilot Feasibility Stud. 2026. PMID: 41918050 Free article.
Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment.
Kurapati S, Shin C, Szabo K, Liu Y, Ashraf AZ, Koscso B, Dash C, Kruckow KL, Navarro LE, Clark AM, Saha M, Nagaraj S, Wang W, Zhu J, Brown K, Thomson T, Shulzhenko N, Morgun A, Baer CE, Srinivasan S, Kulkarni S, Pasricha PJ, Peters LA, Bogunovic M. Kurapati S, et al. J Exp Med. 2026 Apr 6;223(4):e20251761. doi: 10.1084/jem.20251761. Epub 2026 Mar 3. J Exp Med. 2026. PMID: 41774078
eQTL in diseased colon tissue identifies potential target genes associated with IBD.
Nishiyama NC, Silverstein S, Darlington K, Kennedy Ng MM, Clough KM, Bauer M, Beasley C, Bharadwaj A, Ganesan R, Kapadia MR, Lau G, Lian G, Rahbar R, Sadiq TS, Schaner MR, Stem J, Friton J, Faubion WA Jr, Sheikh SZ, Furey TS. Nishiyama NC, et al. Nat Commun. 2026 Feb 13;17(1):2736. doi: 10.1038/s41467-026-69364-6. Nat Commun. 2026. PMID: 41688467 Free PMC article.
Feasibility and performance of minimal-volume capillary blood screening for type 1 diabetes and coeliac disease autoantibodies across all age groups: the UNISCREEN population study.
Marzinotto I, Bazzigaluppi E, Brigatti C, Martinenghi S, Laurenzi A, Ancona G, Angiulli S, Borgonovo E, Spanò A, Pata G, Mallus M, Ulivi F, Achenbach P, Hagopian W, Gillespie K, Lampasona V, Bosi E. Marzinotto I, et al. Diabetologia. 2026 May;69(5):1282-1294. doi: 10.1007/s00125-026-06680-y. Epub 2026 Feb 10. Diabetologia. 2026. PMID: 41665666 Free PMC article.
Distinct Enterovirus Antigen Landscape in Children With Islet Autoimmunity.
Delgado-Corrales B, Fingerhut L, Leung P, Yau CSA, Foster CSP, Ward EJ, Foskett DB, Annadurai A, Barry SC, Colman PG, Couper JJ, Davis EA, Hamilton-Williams EE, Harrison LC, Haynes A, Huynh T, McGorm KJ, Morahan G, Oakey H, Penno MAS, Soldatos G, Thomson RL, Tye-Din JA, Vuillermin PJ, Wentworth JM, Wilkins MR, Laiho JE, Hyöty H, Rawlinson WD, Craig ME, Kim KW; ENDIA Study Group. Delgado-Corrales B, et al. Diabetes. 2026 Apr 1;75(4):738-747. doi: 10.2337/db25-0805. Diabetes. 2026. PMID: 41662565 Free PMC article.
Effect of High-Dose Oral Insulin in Children With Stage 1 Type 1 Diabetes: The Fr1da Insulin Intervention Randomized Controlled Trial.
Ziegler AG, Albeer A, Arnolds S, Assfalg R, Bunk M, Daniel C, Hofelich A, Jacobsen S, Kick K, Knoop J, Kohls M, Kordonouri O, Matzke C, Pfirrmann M, Ramminger C, Sarcletti K, Scholz M, Schütte-Borkovec K, Serr I, Weigelt M, Weiss A, Winkler C, Bonifacio E, Achenbach P. Ziegler AG, et al. Diabetes Care. 2026 Jan 21:dc252818. doi: 10.2337/dc25-2818. Online ahead of print. Diabetes Care. 2026. PMID: 41563349
A Comparison of Diet and Exercise During Pregnancy in Women With and Without Type 1 Diabetes Followed in the Environmental Determinants of Islet Autoimmunity (ENDIA) Study.
Thomson RL, Martin G, Brown JD, Oakey H, Ashwood P, Penno MAS, McGorm KJ, Battersby R, Colman PG, Craig ME, Davis EA, Huynh T, Haynes A, Spelman T, Soldatos G, Vuillermin PJ, Wentworth JM, Price SAL, Couper JJ; ENDIA Study Group*. Thomson RL, et al. Diabetes Care. 2026 Mar 1;49(3):471-477. doi: 10.2337/dc25-2064. Diabetes Care. 2026. PMID: 41543932
Glucose-dependent insulinotropic polypeptide reduces postprandial glucose excursions but does not protect from hypoglycaemia in persons with type 1 diabetes-A randomised placebo-controlled study.
Hoe B, Heimbürger SMN, Gasbjerg LS, Lanng AR, Lynggaard MB, Lund AB, Dela F, Faber J, Skov-Jeppesen K, Engberg S, Hartmann B, Holst JJ, Vilsbøll T, Christensen MB, Dejgaard TF, Knop FK. Hoe B, et al. Diabetes Obes Metab. 2026 Mar;28(3):1886-1898. doi: 10.1111/dom.70373. Epub 2025 Dec 28. Diabetes Obes Metab. 2026. PMID: 41457348 Clinical Trial.
Fibroblast diversity within human gut-associated lymphoid tissues.
Mörbe UM, Junghus FV, Nos G, Jørgensen PB, Ensmenger MJ, Väänänen VA, Wewer MD, Madsen GR, Riis LB, Jakobsen HL, Olsen LR, Brunak S, Nielsen OH, Agace WW. Mörbe UM, et al. J Exp Med. 2026 Mar 2;223(3):e20250471. doi: 10.1084/jem.20250471. Epub 2025 Dec 11. J Exp Med. 2026. PMID: 41379085 Free PMC article.
Generating functional plasmid origins with OriGen.
Irvine J, Martinson JNV, Arora J, Hasham SI, Patel JR, Qi ET, Cress BF, Rubin BE. Irvine J, et al. Nucleic Acids Res. 2025 Nov 26;53(22):gkaf1198. doi: 10.1093/nar/gkaf1198. Nucleic Acids Res. 2025. PMID: 41325770 Free PMC article.
A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease.
Shojaei Jeshvaghani Z, Argmann C, de Vries MH, van Es JH, Collen LV, Kotlarz D, Sveen M, Comella PH, Snapper SB, Klein C, Schadt EE, Clevers H, Mokry M, Kuijk E, Nieuwenhuis E. Shojaei Jeshvaghani Z, et al. Inflamm Bowel Dis. 2026 Jan 1;32(1):9-24. doi: 10.1093/ibd/izaf296. Inflamm Bowel Dis. 2026. PMID: 41273131
Dynamics and variegation in the Treg response to Interleukin-2.
Seddu K, Chowdhary K, Henderson M, Tomala J, Casey O, Cao Y, Mathis D, Spangler JB, Benoist C. Seddu K, et al. Proc Natl Acad Sci U S A. 2025 Nov 25;122(47):e2518991122. doi: 10.1073/pnas.2518991122. Epub 2025 Nov 20. Proc Natl Acad Sci U S A. 2025. PMID: 41264258
Exploring the impact of different definitions of level 1 and level 2 sensor-detected hypoglycaemia upon frequency of hypoglycaemia and time below range: The Hypo-METRICS study.
Koutroukas V, Thomas J, Martine-Edith G, Divilly P, Meek CL, Pouwer F, Amiel SA, Choudhary P; Hypo‐METRICS Consortium. Koutroukas V, et al. Diabetes Obes Metab. 2026 Jan;28(1):775-778. doi: 10.1111/dom.70238. Epub 2025 Oct 27. Diabetes Obes Metab. 2026. PMID: 41145372 Free PMC article. No abstract available.
Blood proteomic signatures associated with disease activity in inflammatory bowel diseases.
Veyssière M, Hammoudi N, Le Bourhis L, Hassid D, Bonnet J, Tran Minh ML, Baudry C, Gornet JM, Chardiny V, Seksik P, Nancey S, Carbonnel F, Treton X, Wils P, Buisson A, Boureille A, Hébuterne X, Serrero M, Fumery M, Louis E, Blanc P, Peyrin-Biroulet L, Bezault M, Soumelis V, Allez M. Veyssière M, et al. J Crohns Colitis. 2025 Sep 28;19(9):jjaf162. doi: 10.1093/ecco-jcc/jjaf162. J Crohns Colitis. 2025. PMID: 40920365 Free article.
Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease.
Mahadevan U, Seow CH, Barnes EL, Chaparro M, Flanagan E, Friedman S, Julsgaard M, Kane S, Ng S, Torres J, Watermeyer G, Yamamoto-Furusho J, Robinson C, Fisher S, Anderson P, Gearry R, Duricova D, Dubinsky M, Long M; Global Consensus Group for Pregnancy and IBD. Mahadevan U, et al. J Crohns Colitis. 2025 Sep 7;19(8):jjaf129. doi: 10.1093/ecco-jcc/jjaf129. J Crohns Colitis. 2025. PMID: 40914850
Global Consensus Statement on the Management of Pregnancy in Inflammatory Bowel Disease.
Mahadevan U, Seow CH, Barnes EL, Chaparro M, Flanagan E, Friedman S, Julsgaard M, Kane S, Ng S, Torres J, Watermeyer G, Yamamoto-Furusho J, Robinson C, Fisher S, Anderson P, Gearry R, Duricova D, Dubinsky M, Long M; Global Consensus Group for Pregnancy and IBD. Mahadevan U, et al. Inflamm Bowel Dis. 2025 Oct 1;31(10):2615-2664. doi: 10.1093/ibd/izaf171. Inflamm Bowel Dis. 2025. PMID: 40874613
Longitudinal Continuous Glucose Monitoring Study in Young Children With Presymptomatic Type 1 Diabetes Followed in the Environmental Determinants of Islet Autoimmunity (ENDIA) At-Risk Cohort Study.
Haynes A, Smith GJ, Tully A, Mellor BR, Penno MAS, Craig ME, Wentworth JM, Huynh T, Colman PG, Soldatos G, Anderson AJ, McGorm KJ, Couper JJ, Davis EA; Environmental Determinants of Islet Autoimmunity (ENDIA) Study Group. Haynes A, et al. Diabetes Care. 2025 Oct 1;48(10):1812-1817. doi: 10.2337/dc25-0821. Diabetes Care. 2025. PMID: 40828811 Free PMC article.
Microbial Shift Over 1 Year Among Patients With Newly Diagnosed Crohn's Disease Reflects Clinical Trajectory and Exposure to Biologic Treatment: A Prospective Real-World Inception Cohort.
Sharar Fischler T, Reshef L, Godny L, Goren I, Ollech JE, Avni-Biron I, Banai Eran H, Snir Y, Broitman Y, Pfeffer-Gik T, Freidenberg A, Pauker MH, Rabinowitz KM, Gophna U, Dotan I, Yanai H; Israeli IBD Research Nucleus (IIRN). Sharar Fischler T, et al. Clin Transl Gastroenterol. 2025 Sep 1;16(9):e00902. doi: 10.14309/ctg.0000000000000902. Clin Transl Gastroenterol. 2025. PMID: 40794137 Free PMC article.
Adverse pregnancy outcomes in women with type 1 diabetes are associated with multiple alterations in the vaginal microbiome.
Roth-Schulze AJ, Bandala-Sanchez E, Ngui KM, Naselli G, Oakey H, Ashwood P, Martin G, Brown JD, Zozaya-Valdés E, Thomson RL, Colman PG, Wentworth JM, Vuillermin PJ, Hunyh T, Soldatos G, Couper JJ, Penno MAS, Harrison LC; ENDIA Study Group. Roth-Schulze AJ, et al. Diabetologia. 2025 Nov;68(11):2552-2566. doi: 10.1007/s00125-025-06509-0. Epub 2025 Aug 7. Diabetologia. 2025. PMID: 40775532 Free PMC article.
Volumetric Changes in Perianal Fistulizing Crohn's Disease Measured by Magnetic Resonance Is Feasible and Could Be a Potential Biomarker to Predict Clinical Outcomes.
Caballol B, Ordás I, Saavedra C, Saidman J, Masamunt MC, Gallego M, Barastegui R, Fernández-Clotet A, Menys A, Panés J, Ricart E, Rimola J. Caballol B, et al. United European Gastroenterol J. 2025 Sep;13(7):1217-1225. doi: 10.1002/ueg2.70003. Epub 2025 Jul 18. United European Gastroenterol J. 2025. PMID: 40679916 Free PMC article.
Fecal and Serum Metabolome in Crohn's Disease is Linked With Future Flare.
Levhar N, Hadar R, Braun T, Naamneh R, Efroni G, Agranovich B, Abramovich I, Asher AT, Picard O, Lahat A, Yablecovitch D, Kopylov U, Eliakim R, Ben-Horin S, Amir A, Haberman Y; Israeli IBD Research Nucleus (IIRN). Levhar N, et al. United European Gastroenterol J. 2025 Sep;13(7):1278-1288. doi: 10.1002/ueg2.70073. Epub 2025 Jul 12. United European Gastroenterol J. 2025. PMID: 40650893 Free PMC article.
A microRNA-based dynamic risk score for type 1 diabetes.
Joglekar MV, Wong WKM, Kunte PS, Hardikar HP, Kulkarni RA, Ahmed I, Farr RJ, Pham NHT, Coles M, Kaur S, Maynard CL, Hayward R, Thorat V, Pant A, Akil AA, Donaghue KC, Jenkins AJ, Piya MK, Craig ME, Hague WM, Yajnik CS, Chan JCN, Shapiro AMJ, Davis EA, Jones TW, Gitelman SE, Ma RCW, Pociot F, Hardikar AA; PREDICT T1D Study Group. Joglekar MV, et al. Nat Med. 2025 Aug;31(8):2622-2631. doi: 10.1038/s41591-025-03730-7. Epub 2025 Jun 5. Nat Med. 2025. PMID: 40473952 Free PMC article.
Smaller Pancreas Volume in Insulin-Dependent Monogenic Diabetes.
Williams JM, Hilmes MA, Letourneau-Freiberg LR, Kandasamy B, Braun D, Greeley SAW, Philipson L, Powers AC, Virostko J, Moore DJ, Wright JJ. Williams JM, et al. Diabetes. 2025 Aug 1;74(8):1411-1416. doi: 10.2337/db25-0318. Diabetes. 2025. PMID: 40402101
HLA DQA1*05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children With Crohn's Disease.
Adler J, Galanko JA, Ammoury R, Benkov KJ, Bousvaros A, Boyle B, Cabrera JM, Chun KY, Dorsey J, Ebach DR, Firestine AM, Gulati AS, Herfarth HH, Jester TW, Kaplan JL, Leibowitz I, Linville TM, Margolis PA, Minar P, Molle-Rios Z, Moses J, Olano K, Pashankar DS, Pitch L, Saeed SA, Samson CM, Sandberg K, Steiner SJ, Strople JA, Sullivan JS, Wali PD, Kappelman MD. Adler J, et al. Am J Gastroenterol. 2025 May 1;120(5):1076-1086. doi: 10.14309/ajg.0000000000003135. Epub 2024 Oct 18. Am J Gastroenterol. 2025. PMID: 40315028 Clinical Trial.
Statin Use Is Associated With Protection Against Acute Cholangitis in Patients With Primary Sclerosing Cholangitis: A Multicenter Retrospective Cohort Study.
Kulkarni C, Cholankeril G, Fardeen T, Rathkey J, Khan S, Murag S, Lerrigo R, Kamal A, Mannalithara A, Jalal P, Ahmed A, Vierling J, Goel A, Sinha SR. Kulkarni C, et al. Clin Transl Gastroenterol. 2025 Apr 1;16(4):e00816. doi: 10.14309/ctg.0000000000000816. Clin Transl Gastroenterol. 2025. PMID: 40272937 Free PMC article.
Genetics of circulating proteins in newborn babies at high risk of type 1 diabetes.
Tutino M, Yu NY, Hatzikotoulas K, Park YC, Kreitmaier P, Katsoula G, Berner R, Casteels K, Elding Larsson H, Kordonouri O, Ołtarzewski M, Szypowska A, Ott R, Weiss A, Winkler C, Zapardiel-Gonzalo J, Petrera A, Hauck SM, Bonifacio E, Ziegler AG, Zeggini E. Tutino M, et al. Nat Commun. 2025 Apr 22;16(1):3750. doi: 10.1038/s41467-025-58972-3. Nat Commun. 2025. PMID: 40263317 Free PMC article.
The extra-islet pancreas supports autoimmunity in human type 1 diabetes.
Barlow GL, Schürch CM, Bhate SS, Phillips DJ, Young A, Dong S, Martinez HA, Kaber G, Nagy N, Ramachandran S, Meng J, Korpos E, Bluestone JA, Nolan GP, Bollyky PL. Barlow GL, et al. Elife. 2025 Apr 15;13:RP100535. doi: 10.7554/eLife.100535. Elife. 2025. PMID: 40232951 Free PMC article.
The Visibility and Performance of Small Bowel Video Capsule Endoscopy With and Without Pre-Procedural Purge Preparation in the Same Patients.
Margalit Yehuda R, Davidov Y, Selinger L, Ungar B, Lahat A, Yablecovitch D, Neuman S, Kopylov U, Ben Horin S, Eliakim R; Israeli IBD Research Nucleus (IIRN). Margalit Yehuda R, et al. J Gastroenterol Hepatol. 2025 Jun;40(6):1485-1491. doi: 10.1111/jgh.16954. Epub 2025 Apr 3. J Gastroenterol Hepatol. 2025. PMID: 40176636 Free PMC article. Clinical Trial.
GPR35 prevents osmotic stress induced cell damage.
Elias JE, Debela M, Sewell GW, Stopforth RJ, Partl H, Heissbauer S, Holland LM, Karlsen TH, Kaser A, Kaneider NC. Elias JE, et al. Commun Biol. 2025 Mar 22;8(1):478. doi: 10.1038/s42003-025-07848-9. Commun Biol. 2025. PMID: 40121360 Free PMC article.
The efficacy of islet autoantibody screening with or without genetic pre-screening strategies for the identification of presymptomatic type 1 diabetes.
Bonifacio E, Coelho R, Ewald DA, Gemulla G, Hubmann M, Jarosz-Chobot P, Kohls M, Kordonouri O, Lampasona V, Narendran P, Pociot F, Šumník Z, Szypowska A, Zapardiel-Gonzalo J, Ziegler AG. Bonifacio E, et al. Diabetologia. 2025 Jun;68(6):1101-1107. doi: 10.1007/s00125-025-06408-4. Epub 2025 Mar 19. Diabetologia. 2025. PMID: 40105972 Free PMC article.
Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes.
Rodriguez-Calvo T, Laiho JE, Oikarinen M, Akhbari P, Flaxman C, Worthington T, Apaolaza P, Kaddis JS, Kusmartseva I, Tauriainen S, Campbell-Thompson M, Atkinson MA, von Herrath M, Hyöty H, Morgan NG, Pugliese A, Richardson SJ; nPOD-Virus group. Rodriguez-Calvo T, et al. Diabetologia. 2025 Jun;68(6):1197-1210. doi: 10.1007/s00125-025-06384-9. Epub 2025 Mar 17. Diabetologia. 2025. PMID: 40090995 Free PMC article.
Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue.
Richardson SJ, Rodriguez-Calvo T, Laiho JE, Kaddis JS, Nyalwidhe JO, Kusmartseva I, Morfopoulou S, Petrosino JF, Plagnol V, Maedler K, Morris MA, Nadler JL, Atkinson MA, von Herrath M, Lloyd RE, Hyoty H, Morgan NG, Pugliese A; nPOD-Virus Group. Richardson SJ, et al. Diabetologia. 2025 Jun;68(6):1226-1241. doi: 10.1007/s00125-025-06401-x. Epub 2025 Mar 17. Diabetologia. 2025. PMID: 40090994 Free PMC article.
Definitions, diagnosis, and management of postoperative recurrence in Crohn's disease patients with permanent ileostomy-a systematic review and meta-analysis.
Abushamma S, Yadete T, Nero N, Falloon K, Parker CE, Abreu MT, Ahuja V, Armuzzi A, Bemelman W, Bruining DH, Deepak P, Dignass A, Dotan I, Feagan BG, Fulmer C, Halfvarson J, Hart A, Holubar SD, Leong RW, Ma C, Magro F, McCurdy JD, Narula N, Panés J, Raine T, Regueiro M, Rogler G, Singh S, Sparrow MP, Spinelli A, Van Koughnett JA, Vuyyuru SK, Solitano V, Yuan Y, Jairath V, Rieder F. Abushamma S, et al. J Crohns Colitis. 2025 Apr 4;19(4):jjaf041. doi: 10.1093/ecco-jcc/jjaf041. J Crohns Colitis. 2025. PMID: 40066499
Marked improvement in HbA1c following introduction of biosimilar insulin to treatment regimen of children and youth with type 1 diabetes in Mali: A randomised controlled trial.
Besançon S, Haynes A, Togo AD, Sandy JL, Maniam J, Sidibe AT, Djéneba S, de Beaufort C, Perolini MC, Gastaldi G, Beran D, Eigenmann C, Ogle GD. Besançon S, et al. Diabet Med. 2025 May;42(5):e70007. doi: 10.1111/dme.70007. Epub 2025 Mar 3. Diabet Med. 2025. PMID: 40033680 Clinical Trial.
Circulating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease.
Dillman JR, Tkach JA, Fletcher JG, Bruining DH, Lu A, Kugathasan S, Alazraki AL, Knight-Scott J, Stidham RW, Adler J, Minar P, Trapnell BC, Bonkowski EL, Jurrell H, Lopez-Nunez O, Collins MH, Swanson SD, Fei L, Qian L, Towbin AJ, Kocaoglu M, Anton CG, Imbus RA, Dudley JA, Denson LA. Dillman JR, et al. Inflamm Bowel Dis. 2025 May 12;31(5):1380-1391. doi: 10.1093/ibd/izae319. Inflamm Bowel Dis. 2025. PMID: 39853252 Free PMC article.
Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells.
Carré A, Samassa F, Zhou Z, Perez-Hernandez J, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, Brandao B, Colli ML, Eizirik DL, Aluri J, Patel D, Göransson M, Burgos Morales O, Anderson A, Landry L, Kobaisi F, Scharfmann R, Marselli L, Marchetti P, You S, Nakayama M, Hadrup SR, Kent SC, Richardson SJ, Ternette N, Mallone R. Carré A, et al. Nat Commun. 2025 Jan 17;16(1):765. doi: 10.1038/s41467-025-55908-9. Nat Commun. 2025. PMID: 39824805 Free PMC article.
Long-term outcome of pediatric acute severe colitis: A prospective 5-year follow-up of the PRASCO trial.
Lachman D, Orlanski-Meyer E, Lev-Tzion R, Ledder O, Assa A, Shavit-Brunschwig Z, Yerushalmi B, Aloi M, Griffiths AM, Albenberg L, Bar-Or I, Kolho KL, Shouval DS, Cohen S, Turner D, Atia O. Lachman D, et al. J Pediatr Gastroenterol Nutr. 2025 Mar;80(3):433-439. doi: 10.1002/jpn3.12442. Epub 2024 Dec 24. J Pediatr Gastroenterol Nutr. 2025. PMID: 39718121 Free PMC article.
Project ECHO Diabetes Trial Improves Outcomes for Medically Underserved People.
Walker AF, Haller MJ, Addala A, Filipp SL, Lal RA, Gurka MJ, Figg LE, Hechavarria M, Zaharieva DP, Malden KG, Hood KK, Westen SC, Wong JJ, Donahoo WT, Basina M, Bernier AV, Maahs DM; ECHO Diabetes Study Team. Walker AF, et al. Diabetes Care. 2025 Feb 1;48(2):243-250. doi: 10.2337/dc24-2100. Diabetes Care. 2025. PMID: 39688288 Free PMC article. Clinical Trial.
Protocol for a feasibility and acceptability study for UK general population paediatric type 1 diabetes screening-the EarLy Surveillance for Autoimmune diabetes (ELSA) study.
Quinn LM, Dias RP, Greenfield SM, Richter AG, Garstang J, Shukla D, Acharjee A, Gkoutos G, Oram R, Faustini S, Boiko O, Litchfield I, Boardman F, Zakia F, Burt C, Connop C, Lepley A, Gardner C, Dayan C, Barrett T, Narendran P. Quinn LM, et al. Diabet Med. 2025 May;42(5):e15490. doi: 10.1111/dme.15490. Epub 2024 Dec 2. Diabet Med. 2025. PMID: 39623620 Free PMC article.
Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis.
Ghasempour S, Warner N, Guan R, Rodari MM, Ivanochko D, Whittaker Hawkins R, Marwaha A, Nowak JK, Liang Y, Mulder DJ, Stallard L, Li M, Yu DD, Pluthero FG, Batura V, Zhao M, Siddiqui I, Upton JEM, Hulst JM, Kahr WHA, Mendoza-Londono R, Charbit-Henrion F, Hoefsloot LH, Khiat A, Moreira D, Trindade E, Espinheira MDC, Pinto Pais I, Weerts MJA, Douben H, Kotlarz D, Snapper SB, Klein C, Dowling JJ, Julien JP, Joosten M, Cerf-Bensussan N, Freeman SA, Parlato M, van Ham TJ, Muise AM. Ghasempour S, et al. J Exp Med. 2024 Dec 2;221(12):e20240546. doi: 10.1084/jem.20240546. Epub 2024 Nov 11. J Exp Med. 2024. PMID: 39526957 Free PMC article.
The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium.
Hanna SJ, Bonami RH, Corrie B, Westley M, Posgai AL, Luning Prak ET, Breden F, Michels AW, Brusko TM; Type 1 Diabetes AIRR Consortium. Hanna SJ, et al. Diabetologia. 2025 Jan;68(1):186-202. doi: 10.1007/s00125-024-06298-y. Epub 2024 Oct 29. Diabetologia. 2025. PMID: 39467874 Free PMC article.
A Proteomics Pipeline for Generating Clinical Grade Biomarker Candidates from Data-Independent Acquisition Mass Spectrometry (DIA-MS) Discovery.
Fu Q, Vegesna M, Sundararaman N, Damoc E, Arrey TN, Pashkova A, Mengesha E, Debbas P, Joung S, Li D, Cheng S, Braun J, McGovern DPB, Murray CI, Xuan Y, Van Eyk JE. Fu Q, et al. Angew Chem Int Ed Engl. 2024 Dec 20;63(52):e202409446. doi: 10.1002/anie.202409446. Epub 2024 Nov 11. Angew Chem Int Ed Engl. 2024. PMID: 39432331
Low Anti-Tumor Necrosis Factor Levels During Maintenance Phase Are Associated With Treatment Failure in Children With Crohn's Disease.
Moses J, Adler J, Saeed SA, Firestine AM, Galanko JA, Ammoury RF, Bass DM, Bass JA, Bastidas M, Benkov KJ, Bousvaros A, Cabrera JM, Chun KY, Dorsey JM, Ebach DR, Gulati AS, Herfarth HH, Ivanova A, Jester TW, Kaplan JL, Kusek ME, Leibowitz IH, Linville TM, Margolis PA, Minar P, Molle-Rios Z, Niklinska-Schirtz BJ, Olano KK, Osaba L, Palomo PJ, Pashankar DS, Pitch L, Samson CM, Sandberg KC, Steiner SJ, Strople JA, Sullivan JS, Tung J, Wali P, Wohl DA, Zikry M, Boyle BM, Kappelman MD. Moses J, et al. Inflamm Bowel Dis. 2025 Jul 7;31(7):1841-1850. doi: 10.1093/ibd/izae239. Inflamm Bowel Dis. 2025. PMID: 39418336 Clinical Trial.
Durable Immune Response and Long-term Efficacy of COVID-19 Vaccination in Children With Inflammatory Bowel Disease.
Kastl AJ, Brenner EJ, Weaver KN, Zhang X, Strople JA, Adler J, Dubinsky MC, Bousvaros A, Watkins R, Dai X, Chen W, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Chun KY, Zikry M, Bastidas M, Firestine AM, Craig RG, Boccieri ME, Long MD, Kappelman MD. Kastl AJ, et al. Inflamm Bowel Dis. 2025 Jul 7;31(7):1797-1805. doi: 10.1093/ibd/izae225. Inflamm Bowel Dis. 2025. PMID: 39412147
Noninvasive, microbiome-based diagnosis of inflammatory bowel disease.
Zheng J, Sun Q, Zhang M, Liu C, Su Q, Zhang L, Xu Z, Lu W, Ching J, Tang W, Cheung CP, Hamilton AL, Wilson O'Brien AL, Wei SC, Bernstein CN, Rubin DT, Chang EB, Morrison M, Kamm MA, Chan FKL, Zhang J, Ng SC. Zheng J, et al. Nat Med. 2024 Dec;30(12):3555-3567. doi: 10.1038/s41591-024-03280-4. Epub 2024 Oct 4. Nat Med. 2024. PMID: 39367251 Free PMC article.
The Circulating Methylome in Childhood-Onset Inflammatory Bowel Disease.
Noble A, Adams A, Nowak J, Cheng G, Nayak K, Quinn A, Kristiansen M, Kalla R, Ventham NT, Giachero F, Jayamanne C, Hansen R, Hold GL, El-Omar E, Croft NM, Wilson D, Beattie RM, Ashton JJ, Zilbauer M, Ennis S, Uhlig HH, Satsangi J. Noble A, et al. J Crohns Colitis. 2025 Mar 5;19(3):jjae157. doi: 10.1093/ecco-jcc/jjae157. J Crohns Colitis. 2025. PMID: 39365013 Free PMC article.
Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes.
Hill TG, Gao R, Benrick A, Kothegala L, Rorsman N, Santos C, Acreman S, Briant LJ, Dou H, Gandasi NR, Guida C, Haythorne E, Wallace M, Knudsen JG, Miranda C, Tolö J, Clark A, Davison L, Størling J, Tarasov A, Ashcroft FM, Rorsman P, Zhang Q. Hill TG, et al. Nat Metab. 2024 Nov;6(11):2070-2081. doi: 10.1038/s42255-024-01139-z. Epub 2024 Sep 23. Nat Metab. 2024. PMID: 39313541 Free PMC article.
Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent Stem Cell-Derived Macrophage-Human Intestinal Organoid Model of Crohn's Disease.
Jurickova I, Dreskin BW, Angerman E, Bonkowski E, Nguyen J, Villarreal R, Tominaga K, Iwasawa K, Braun T, Takebe T, Helmrath MA, Haberman Y, Wells JM, Denson LA. Jurickova I, et al. J Crohns Colitis. 2025 Feb 4;19(2):jjae139. doi: 10.1093/ecco-jcc/jjae139. J Crohns Colitis. 2025. PMID: 39212594 Free PMC article.
Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease.
Li J, Simmons AJ, Hawkins CV, Chiron S, Ramirez-Solano MA, Tasneem N, Kaur H, Xu Y, Revetta F, Vega PN, Bao S, Cui C, Tyree RN, Raber LW, Conner AN, Pilat JM, Jacobse J, McNamara KM, Allaman MM, Raffa GA, Gobert AP, Asim M, Goettel JA, Choksi YA, Beaulieu DB, Dalal RL, Horst SN, Pabla BS, Huo Y, Landman BA, Roland JT, Scoville EA, Schwartz DA, Washington MK, Shyr Y, Wilson KT, Coburn LA, Lau KS, Liu Q. Li J, et al. Nat Commun. 2024 Aug 22;15(1):7204. doi: 10.1038/s41467-024-51580-7. Nat Commun. 2024. PMID: 39169060 Free PMC article.
Performance of bowel preparation quality scales in patients with Crohn's disease.
Solitano V, Siegel CA, Korzenik JR, Maratt JK, Rex DK, Maguire B, Bressler B, Grossmann J, Sedano R, McDonald JWD, Remillard J, Shackelton LM, Zou G, Feagan BG, Ma C, Jairath V. Solitano V, et al. Aliment Pharmacol Ther. 2024 Oct;60(8):1042-1050. doi: 10.1111/apt.18210. Epub 2024 Aug 11. Aliment Pharmacol Ther. 2024. PMID: 39129393
Discordant Effects of Janus Kinase Inhibition Ex Vivo on Inflammatory Responses in Colonic Compared to Ileal Mucosa.
Kaboub K, Abu-Taha H, Arrouasse J, Shaham-Barda E, Wasserberg N, Hayman-Manzur L, Friedenberg A, Levy-Barda A, Goren I, Levi Z, Banai-Eran H, Avni-Biron I, Ollech JE, Sharar-Fischler T, Yanai H, Cohen-Kedar S, Dotan I, Rabinowitz KM. Kaboub K, et al. J Crohns Colitis. 2025 Jan 11;19(1):jjae117. doi: 10.1093/ecco-jcc/jjae117. J Crohns Colitis. 2025. PMID: 39073573
Empowering emerging adults with type 1 diabetes: crafting a financial and health insurance toolkit through community-based participatory action research.
Blanchette JE, Lewis CB, Shannon CS, Kanchibhatla A, Rieke J, Roche MJ, Johnson DA, Williams D, Webb S, Diaz CN, Lundgrin EL, Allen NA, Litchman ML, Hatipoglu B. Blanchette JE, et al. Res Involv Engagem. 2024 Jul 23;10(1):75. doi: 10.1186/s40900-024-00602-1. Res Involv Engagem. 2024. PMID: 39044303 Free PMC article.
Involving different stakeholders in prioritising outcomes to assess healthcare systems response for type 1 diabetes management: Using co-creation approaches in Peru.
Zafra-Tanaka JH, Almeida G, Andrade Montalvo JE, Anza-Ramirez C, Jauregui J, Perez-Leon S, Lazo-Porras M, Mayo-Puchoc N, Taype-Rondán A, Miranda JJ, Beran D. Zafra-Tanaka JH, et al. Int J Health Plann Manage. 2024 Nov;39(6):1675-1695. doi: 10.1002/hpm.3821. Epub 2024 Jul 18. Int J Health Plann Manage. 2024. PMID: 39030852
Multi-omics analysis reveals drivers of loss of β-cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study.
Armenteros JJA, Brorsson C, Johansen CH, Banasik K, Mazzoni G, Moulder R, Hirvonen K, Suomi T, Rasool O, Bruggraber SFA, Marcovecchio ML, Hendricks E, Al-Sari N, Mattila I, Legido-Quigley C, Suvitaival T, Chmura PJ, Knip M, Schulte AM, Lee JH, Sebastiani G, Grieco GE, Elo LL, Kaur S, Pociot F, Dotta F, Tree T, Lahesmaa R, Overbergh L, Mathieu C, Peakman M, Brunak S; INNODIA investigators. Armenteros JJA, et al. Diabetes Metab Res Rev. 2024 Jul;40(5):e3833. doi: 10.1002/dmrr.3833. Diabetes Metab Res Rev. 2024. PMID: 38961656
Effect of 48 Months of Closed-Loop Insulin Delivery on Residual C-Peptide Secretion and Glycemic Control in Newly Diagnosed Youth With Type 1 Diabetes: A Randomized Trial.
Ware J, Boughton CK, Allen JM, Wilinska ME, Hartnell S, Thankamony A, Randell T, Ghatak A, Besser REJ, Elleri D, Trevelyan N, Campbell FM, Sibayan J, Bailey R, Calhoun P, Dunseath G, Hovorka R; CLOuD Consortium. Ware J, et al. Diabetes Care. 2024 Aug 1;47(8):1441-1448. doi: 10.2337/dc24-0360. Diabetes Care. 2024. PMID: 38924772 Free PMC article. Clinical Trial.
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