MR/L006758/1/MRC_/Medical Research Council/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2013	8
2014	47
2015	65
2016	42
2017	48
2018	56
2019	72
2020	35
2021	31
2022	20
2023	19
2026	0

1

ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon.

Hartmann S, Yasmeen S, Jacobs BM, Denaxas S, Pirmohamed M, Gamazon ER, Caulfield MJ; Genes & Health Research Team; Hemingway H, Pietzner M, Langenberg C. Hartmann S, et al. Nat Commun. 2023 Oct 12;14(1):6156. doi: 10.1038/s41467-023-41876-5. Nat Commun. 2023. PMID: 37828025 Free PMC article.

2

Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case-control study.

Grove JI, Stephens C, Lucena MI, Andrade RJ, Weber S, Gerbes A, Bjornsson ES, Stirnimann G, Daly AK, Hackl M, Khamina-Kotisch K, Marin JJG, Monte MJ, Paciga SA, Lingaya M, Forootan SS, Goldring CEP, Poetz O, Lombaard R, Stege A, Bjorrnsson HK, Robles-Diaz M, Li D, Tran TDB, Ramaiah SK, Samodelov SL, Kullak-Ublick GA, Aithal GP; TransBioLine consortium. Grove JI, et al. Diagn Progn Res. 2023 Sep 12;7(1):18. doi: 10.1186/s41512-023-00155-z. Diagn Progn Res. 2023. PMID: 37697410 Free PMC article.

3

A systems approach reveals species differences in hepatic stress response capacity.

Russomanno G, Sison-Young R, Livoti LA, Coghlan H, Jenkins RE, Kunnen SJ, Fisher CP, Reddyhoff D, Gardner I, Rehman AH, Fenwick SW, Jones AR, Vermeil De Conchard G, Simonin G, Bertheux H, Weaver RJ, Johnson RL, Liguori MJ, Clausznitzer D, Stevens JL, Goldring CE, Copple IM. Russomanno G, et al. Toxicol Sci. 2023 Oct 30;196(1):112-125. doi: 10.1093/toxsci/kfad085. Toxicol Sci. 2023. PMID: 37647630 Free PMC article.

4

In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells.

Pridgeon CS, Forootan SS, Zhang F, Harper N, Palmer D, Weightmann R, Gregory S, Hewitt Z, Baker D, Halliwell J, Moore H, Ricci E, Andrews PW, Poptani H, Hay DC, Park BK, Goldring CEP. Pridgeon CS, et al. J Stem Cells Regen Med. 2023 Apr 30;19(1):3-13. doi: 10.46582/jsrm.1901002. eCollection 2023. J Stem Cells Regen Med. 2023. PMID: 37366409 Free PMC article.

5

The Implementation of Pharmacogenetics in the United Kingdom.

McDermott JH, Sharma V, Keen J, Newman WG, Pirmohamed M. McDermott JH, et al. Handb Exp Pharmacol. 2023;280:3-32. doi: 10.1007/164_2023_658. Handb Exp Pharmacol. 2023. PMID: 37306816

6

TNF-α induced extracellular release of keratinocyte high-mobility group box 1 in Stevens-Johnson syndrome/toxic epidermal necrolysis: Biomarker and putative mechanism of pathogenesis.

Nwikue G, Olsson-Brown A, Aboheimed N, Yip V, Jolly C, Luchian A, Ressel L, Sharma A, Bergfeld W, Ahmed S, Dickinson A, Pirmohamed M, Carr DF. Nwikue G, et al. J Dermatol. 2023 Sep;50(9):1129-1139. doi: 10.1111/1346-8138.16847. Epub 2023 Jun 2. J Dermatol. 2023. PMID: 37269158 Free PMC article.

7

Increasing trend in hospitalisation due to adverse drug reactions: can we stem the tide?

Walker LE, Pirmohamed M. Walker LE, et al. Drug Ther Bull. 2023 Jun;61(6):87-91. doi: 10.1136/dtb.2022.000050. Epub 2023 May 16. Drug Ther Bull. 2023. PMID: 37193588 Review.

8

Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways.

Quinn LM, Haldenby S, Antzcak P, Fowler A, Bullock K, Kenny J, Gilbert T, Andrews T, Diaz-Nieto R, Fenwick S, Jones R, Costello-Goldring E, Poston G, Greenhalf W, Palmer D, Malik H, Goldring C. Quinn LM, et al. Sci Rep. 2023 Apr 24;13(1):6681. doi: 10.1038/s41598-023-33096-0. Sci Rep. 2023. PMID: 37095160 Free PMC article.

9

VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells.

Mondru AK, Aljasir MA, Alrumayh A, Nithianandarajah GN, Ahmed K, Muller J, Goldring CEP, Wilm B, Cross MJ. Mondru AK, et al. Cells. 2023 Mar 22;12(6):967. doi: 10.3390/cells12060967. Cells. 2023. PMID: 36980305 Free PMC article.

10

Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System.

Ali SE, Meng X, Kafu L, Hammond S, Zhao Q, Ogese M, Sison-Young R, Jones R, Chan B, Livoti L, Sun Y, Sun L, Liu H, Topping A, Goldring C, Zhang F, Naisbitt DJ. Ali SE, et al. Chem Res Toxicol. 2023 Mar 20;36(3):390-401. doi: 10.1021/acs.chemrestox.2c00343. Epub 2023 Feb 22. Chem Res Toxicol. 2023. PMID: 36812109 Free PMC article.

11

Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.

Ali SE, Waddington JC, Lister A, Sison-Young R, Jones RP, Rehman AH, Goldring CEP, Naisbitt DJ, Meng X. Ali SE, et al. Toxicol Sci. 2023 Mar 20;192(1):106-116. doi: 10.1093/toxsci/kfad015. Toxicol Sci. 2023. PMID: 36782357 Free PMC article.

12

Combinations of medicines in patients with polypharmacy aged 65-100 in primary care: Large variability in risks of adverse drug related and emergency hospital admissions.

Fahmi A, Wong D, Walker L, Buchan I, Pirmohamed M, Sharma A, Cant H, Ashcroft DM, van Staa TP. Fahmi A, et al. PLoS One. 2023 Feb 8;18(2):e0281466. doi: 10.1371/journal.pone.0281466. eCollection 2023. PLoS One. 2023. PMID: 36753492 Free PMC article.

13

Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions.

Gibson A, Deshpande P, Campbell CN, Krantz MS, Mukherjee E, Mockenhaupt M, Pirmohamed M, Palubinsky AM, Phillips EJ. Gibson A, et al. J Allergy Clin Immunol. 2023 Feb;151(2):289-300.e4. doi: 10.1016/j.jaci.2022.12.005. J Allergy Clin Immunol. 2023. PMID: 36740326 Free PMC article. Review.

14

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study.

Swen JJ, van der Wouden CH, Manson LE, Abdullah-Koolmees H, Blagec K, Blagus T, Böhringer S, Cambon-Thomsen A, Cecchin E, Cheung KC, Deneer VH, Dupui M, Ingelman-Sundberg M, Jonsson S, Joefield-Roka C, Just KS, Karlsson MO, Konta L, Koopmann R, Kriek M, Lehr T, Mitropoulou C, Rial-Sebbag E, Rollinson V, Roncato R, Samwald M, Schaeffeler E, Skokou M, Schwab M, Steinberger D, Stingl JC, Tremmel R, Turner RM, van Rhenen MH, Dávila Fajardo CL, Dolžan V, Patrinos GP, Pirmohamed M, Sunder-Plassmann G, Toffoli G, Guchelaar HJ; Ubiquitous Pharmacogenomics Consortium. Swen JJ, et al. Lancet. 2023 Feb 4;401(10374):347-356. doi: 10.1016/S0140-6736(22)01841-4. Lancet. 2023. PMID: 36739136 Clinical Trial.

15

Pharmacogenomics: current status and future perspectives.

Pirmohamed M. Pirmohamed M. Nat Rev Genet. 2023 Jun;24(6):350-362. doi: 10.1038/s41576-022-00572-8. Epub 2023 Jan 27. Nat Rev Genet. 2023. PMID: 36707729 Review.

16

Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: Results of GO-CAT and United Kingdom MAGIC consortia.

Hurkmans EGE, Klumpers MJ, Dello Russo C, De Witte W, Guchelaar HJ, Gelderblom H, Cleton-Jansen AM, Vermeulen SH, Kaal S, van der Graaf WTA, Flucke U, Gidding CEM, Schreuder HWB, de Bont ESJM, Caron HN, Gattuso G, Schiavello E, Terenziani M, Massimino M, McCowage G, Nagabushan S, Limaye A, Rose V, Catchpoole D, Jorgensen AL, Barton C, Delaney L, Hawcutt DB, Pirmohamed M, Pizer B, Coenen MJH, Te Loo DMWM. Hurkmans EGE, et al. Front Pharmacol. 2023 Jan 9;13:980309. doi: 10.3389/fphar.2022.980309. eCollection 2022. Front Pharmacol. 2023. PMID: 36699085 Free PMC article.

17

The impact of the COVID-19 pandemic on cardiovascular disease prevention and management.

Dale CE, Takhar R, Carragher R, Katsoulis M, Torabi F, Duffield S, Kent S, Mueller T, Kurdi A, Le Anh TN, McTaggart S, Abbasizanjani H, Hollings S, Scourfield A, Lyons RA, Griffiths R, Lyons J, Davies G, Harris D, Handy A, Mizani MA, Tomlinson C, Thygesen JH, Ashworth M, Denaxas S, Banerjee A, Sterne JAC, Brown P, Bullard I, Priedon R, Mamas MA, Slee A, Lorgelly P, Pirmohamed M, Khunti K, Morris AD, Sudlow C, Akbari A, Bennie M, Sattar N, Sofat R; CVD-COVID-UK Consortium. Dale CE, et al. Nat Med. 2023 Jan;29(1):219-225. doi: 10.1038/s41591-022-02158-7. Epub 2023 Jan 19. Nat Med. 2023. PMID: 36658423 Free article.

18

Analysis of serum microRNA-122 in a randomized controlled trial of N-acetylcysteine for treatment of antituberculosis drug-induced liver injury.

Moosa MS, Russomanno G, Dorfman JR, Gunter H, Patel C, Costello E, Carr D, Maartens G, Pirmohamed M, Goldring C, Cohen K. Moosa MS, et al. Br J Clin Pharmacol. 2023 Jun;89(6):1844-1851. doi: 10.1111/bcp.15661. Epub 2023 Jan 29. Br J Clin Pharmacol. 2023. PMID: 36639145 Free PMC article. Clinical Trial.

19

TNF-α‒Mediated Keratinocyte Expression and Release of Matrix Metalloproteinase 9: Putative Mechanism of Pathogenesis in Stevens‒Johnson Syndrome/Toxic Epidermal Necrolysis.

Olsson-Brown A, Yip V, Ogiji ED, Jolly C, Ressel L, Sharma A, Bergfeld W, Liu X, Khirwadkar N, Bellon T, Dickinson A, Ahmed S, Langton A, Watson R, Pirmohamed M, Carr DF. Olsson-Brown A, et al. J Invest Dermatol. 2023 Jun;143(6):1023-1030.e7. doi: 10.1016/j.jid.2022.11.024. Epub 2022 Dec 26. J Invest Dermatol. 2023. PMID: 36581093 Free article.

20

Polygenic risk scores: An overview from bench to bedside for personalised medicine.

Cross B, Turner R, Pirmohamed M. Cross B, et al. Front Genet. 2022 Nov 11;13:1000667. doi: 10.3389/fgene.2022.1000667. eCollection 2022. Front Genet. 2022. PMID: 36437929 Free PMC article. Review.

21

Drug-Drug-Gene Interactions in Cardiovascular Medicine.

Asiimwe IG, Pirmohamed M. Asiimwe IG, et al. Pharmgenomics Pers Med. 2022 Nov 2;15:879-911. doi: 10.2147/PGPM.S338601. eCollection 2022. Pharmgenomics Pers Med. 2022. PMID: 36353710 Free PMC article. Review.

22

Shared Clavulanate and Tazobactam Antigenic Determinants Activate T-Cells from Hypersensitive Patients.

Ariza A, Jaruthamsophon K, Meng X, Labella M, Adair K, Tailor A, Sukasem C, Whitaker P, Peckham D, Pirmohamed M, Torres MJ, Naisbitt DJ. Ariza A, et al. Chem Res Toxicol. 2022 Nov 21;35(11):2122-2132. doi: 10.1021/acs.chemrestox.2c00231. Epub 2022 Sep 22. Chem Res Toxicol. 2022. PMID: 36137197 Free PMC article.

23

Quercetin attenuates viral infections by interacting with target proteins and linked genes in chemicobiological models.

Rahman MA, Shorobi FM, Uddin MN, Saha S, Hossain MA. Rahman MA, et al. In Silico Pharmacol. 2022 Sep 16;10(1):17. doi: 10.1007/s40203-022-00132-2. eCollection 2022. In Silico Pharmacol. 2022. PMID: 36119653 Free PMC article.

24

Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions.

Osanlou R, Walker L, Hughes DA, Burnside G, Pirmohamed M. Osanlou R, et al. BMJ Open. 2022 Jul 4;12(7):e055551. doi: 10.1136/bmjopen-2021-055551. BMJ Open. 2022. PMID: 35788071 Free PMC article.

25

Effectiveness of the Med Safety mobile application in improving adverse drug reaction reporting by healthcare professionals in Uganda: a protocol for a pragmatic cluster-randomised controlled trial.

Kiguba R, Mwebaza N, Ssenyonga R, Ndagije HB, Nambasa V, Katureebe C, Katumba K, Tregunno P, Harrison K, Karamagi C, Scott KA, Pirmohamed M. Kiguba R, et al. BMJ Open. 2022 Jul 1;12(7):e061725. doi: 10.1136/bmjopen-2022-061725. BMJ Open. 2022. PMID: 35777873 Free PMC article.

26

Multi-ancestry genome-wide association study of asthma exacerbations.

Herrera-Luis E, Ortega VE, Ampleford EJ, Sio YY, Granell R, de Roos E, Terzikhan N, Vergara EE, Hernandez-Pacheco N, Perez-Garcia J, Martin-Gonzalez E, Lorenzo-Diaz F, Hashimoto S, Brinkman P; U-BIOPRED Study Group; Jorgensen AL, Yan Q, Forno E, Vijverberg SJ, Lethem R, Espuela-Ortiz A, Gorenjak M, Eng C, González-Pérez R, Hernández-Pérez JM, Poza-Guedes P, Sardón O, Corcuera P, Hawkins GA, Marsico A, Bahmer T, Rabe KF, Hansen G, Kopp MV, Rios R, Cruz MJ, González-Barcala FJ, Olaguibel JM, Plaza V, Quirce S, Canino G, Cloutier M, Del Pozo V, Rodriguez-Santana JR, Korta-Murua J, Villar J, Potočnik U, Figueiredo C, Kabesch M, Mukhopadhyay S, Pirmohamed M, Hawcutt DB, Melén E, Palmer CN, Turner S, Maitland-van der Zee AH, von Mutius E, Celedón JC, Brusselle G, Chew FT, Bleecker E, Meyers D, Burchard EG, Pino-Yanes M. Herrera-Luis E, et al. Pediatr Allergy Immunol. 2022 Jun;33(6):e13802. doi: 10.1111/pai.13802. Pediatr Allergy Immunol. 2022. PMID: 35754128 Free PMC article.

27

T-cell-mediated hypersensitivity to lumacaftor and ivacaftor in cystic fibrosis.

Semic-Jusufagic A, Ogese MO, Edwards C, Wilkinson M, Nissenbaum C, Lee T, Pirmohamed M, Naisbitt DJ. Semic-Jusufagic A, et al. Pediatr Allergy Immunol. 2022 Jun;33(6):e13815. doi: 10.1111/pai.13815. Pediatr Allergy Immunol. 2022. PMID: 35754124 No abstract available.

28

Study on the Influence of Polymer/Particle Properties on the Resilience of Superhydrophobic Coatings.

Mehanna YA, Crick CR. Mehanna YA, et al. ACS Omega. 2022 May 18;7(21):18052-18062. doi: 10.1021/acsomega.2c01547. eCollection 2022 May 31. ACS Omega. 2022. PMID: 35664566 Free PMC article.

29

Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.

Gardner J, Ogese M, Betts CJ, Pirmohamed M, Naisbitt DJ. Gardner J, et al. Chem Res Toxicol. 2022 Feb 21;35(2):199-202. doi: 10.1021/acs.chemrestox.1c00425. Epub 2022 Feb 2. Chem Res Toxicol. 2022. PMID: 35107993 Free PMC article.

30

Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm.

Asiimwe IG, Blockman M, Cohen K, Cupido C, Hutchinson C, Jacobson B, Lamorde M, Morgan J, Mouton JP, Nakagaayi D, Okello E, Schapkaitz E, Sekaggya-Wiltshire C, Semakula JR, Waitt C, Zhang EJ, Jorgensen AL, Pirmohamed M. Asiimwe IG, et al. CPT Pharmacometrics Syst Pharmacol. 2022 Jan;11(1):20-29. doi: 10.1002/psp4.12740. Epub 2021 Dec 9. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 34889080 Free PMC article.

31

Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration.

Bourgeois S, Carr DF, Musumba CO, Penrose A, Esume C, Morris AP, Jorgensen AL, Zhang JE, Pritchard DM, Deloukas P, Pirmohamed M. Bourgeois S, et al. EBioMedicine. 2021 Dec;74:103728. doi: 10.1016/j.ebiom.2021.103728. Epub 2021 Dec 2. EBioMedicine. 2021. PMID: 34864618 Free PMC article.

32

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity.

Hammond S, Olsson-Brown A, Grice S, Gibson A, Gardner J, Castrejón-Flores JL, Jolly C, Fisher BA, Steven N, Betts C, Pirmohamed M, Meng X, Naisbitt DJ. Hammond S, et al. Toxicol Sci. 2022 Feb 28;186(1):58-69. doi: 10.1093/toxsci/kfab144. Toxicol Sci. 2022. PMID: 34850240 Free PMC article.

33

Corrigendum to 'SJS/TEN 2019: From science to translation' [J. Dermatol. Sci. 98/1 (2020) 2-12].

Chang WC, Abe R, Anderson P, Anderson W, Ardern-Jones MR, Beachkofsky TM, Bellón T, Biala AK, Bouchard C, Cavalleri GL, Chapman N, Chodosh J, Choi HK, Cibotti RR, Divito SJ, Dewar K, Dehaeck U, Etminan M, Forbes D, Fuchs E, Goldman JL, Holmes JH 4th, Hope EA, Hung SI, Hsieh CL, Iovieno A, Jagdeo J, Kim MK, Koelle DM, Lacouture ME, Le Pallec S, Lehloenya RJ, Lim R, Lowe A, McCawley J, McCawley J, Micheletti RG, Mockenhaupt M, Niemeyer K, Norcross MA, Oboh D, Olteanu C, Pasieka HB, Peter J, Pirmohamed M, Rieder M, Saeed HN, Shear NH, Shieh C, Straus S, Sukasem C, Sung C, Trubiano JA, Tsou SY, Ueta M, Volpi S, Wan C, Wang H, Wang ZQ, Weintraub J, Whale C, Wheatley LM, Whyte-Croasdaile S, Williams KB, Wright G, Yeung SN, Zhou L, Chung WH, Phillips EJ, Carleton BC. Chang WC, et al. J Dermatol Sci. 2021 Nov;104(2):146-147. doi: 10.1016/j.jdermsci.2021.09.008. Epub 2021 Nov 9. J Dermatol Sci. 2021. PMID: 34763988 Free PMC article. No abstract available.

34

High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study.

Walker LE, Sills GJ, Jorgensen A, Alapirtti T, Peltola J, Brodie MJ, Marson AG, Vezzani A, Pirmohamed M. Walker LE, et al. Epilepsia. 2022 Jan;63(1):e1-e6. doi: 10.1111/epi.17116. Epub 2021 Nov 8. Epilepsia. 2022. PMID: 34747496 Free article.

35

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.

Whitfield JB, Schwantes-An TH, Darlay R, Aithal GP, Atkinson SR, Bataller R, Botwin G, Chalasani NP, Cordell HJ, Daly AK, Day CP, Eyer F, Foroud T, Gleeson D, Goldman D, Haber PS, Jacquet JM, Liang T, Liangpunsakul S, Masson S, Mathurin P, Moirand R, McQuillin A, Moreno C, Morgan MY, Mueller S, Müllhaupt B, Nagy LE, Nahon P, Nalpas B, Naveau S, Perney P, Pirmohamed M, Seitz HK, Soyka M, Stickel F, Thompson A, Thursz MR, Trépo E, Morgan TR, Seth D; GenomALC Consortium. Whitfield JB, et al. J Hepatol. 2022 Feb;76(2):275-282. doi: 10.1016/j.jhep.2021.10.005. Epub 2021 Oct 14. J Hepatol. 2022. PMID: 34656649 Free PMC article.

36

Roadmap to 2030 for Drug Evaluation in Older Adults.

Liu Q, Schwartz JB, Slattum PW, Lau SWJ, Guinn D, Madabushi R, Burckart G, Califf R, Cerreta F, Cho C, Cook J, Gamerman J, Goldsmith P, van der Graaf PH, Gurwitz JH, Haertter S, Hilmer S, Huang SM, Inouye SK, Kanapuru B, Pirmohamed M, Posner P, Radziszewska B, Keipp Talbot H, Temple R. Liu Q, et al. Clin Pharmacol Ther. 2022 Aug;112(2):210-223. doi: 10.1002/cpt.2452. Epub 2021 Nov 8. Clin Pharmacol Ther. 2022. PMID: 34656074 Free article.

37

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.

Jaruthamsophon K, Thomson PJ, Sukasem C, Naisbitt DJ, Pirmohamed M. Jaruthamsophon K, et al. Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:509-529. doi: 10.1146/annurev-pharmtox-052120-014115. Epub 2021 Sep 13. Annu Rev Pharmacol Toxicol. 2022. PMID: 34516290 Review.

38

Systems analysis of miRNA biomarkers to inform drug safety.

Schofield AL, Brown JP, Brown J, Wilczynska A, Bell C, Glaab WE, Hackl M, Howell L, Lee S, Dear JW, Remes M, Reeves P, Zhang E, Allmer J, Norris A, Falciani F, Takeshita LY, Seyed Forootan S, Sutton R, Park BK, Goldring C. Schofield AL, et al. Arch Toxicol. 2021 Nov;95(11):3475-3495. doi: 10.1007/s00204-021-03150-9. Epub 2021 Sep 12. Arch Toxicol. 2021. PMID: 34510227 Free PMC article. Review.

39

Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy.

Magavern EF, Kaski JC, Turner RM, Drexel H, Janmohamed A, Scourfield A, Burrage D, Floyd CN, Adeyeye E, Tamargo J, Lewis BS, Kjeldsen KP, Niessner A, Wassmann S, Sulzgruber P, Borry P, Agewall S, Semb AG, Savarese G, Pirmohamed M, Caulfield MJ. Magavern EF, et al. Eur Heart J Cardiovasc Pharmacother. 2022 Jan 5;8(1):100-103. doi: 10.1093/ehjcvp/pvab063. Eur Heart J Cardiovasc Pharmacother. 2022. PMID: 34463331 Free PMC article.

40

AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter.

Griffiths GO, FitzGerald R, Jaki T, Corkhill A, Reynolds H, Ewings S, Condie S, Tilt E, Johnson L, Radford M, Simpson C, Saunders G, Yeats S, Mozgunov P, Tansley-Hancock O, Martin K, Downs N, Eberhart I, Martin JWB, Goncalves C, Song A, Fletcher T, Byrne K, Lalloo DG, Owen A, Jacobs M, Walker L, Lyon R, Woods C, Gibney J, Chiong J, Chandiwana N, Jacob S, Lamorde M, Orrell C, Pirmohamed M, Khoo S; AGILE investigators. Griffiths GO, et al. Trials. 2021 Jul 26;22(1):487. doi: 10.1186/s13063-021-05458-4. Trials. 2021. PMID: 34311777 Free PMC article.

41

Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity.

McEvoy L, Carr DF, Pirmohamed M. McEvoy L, et al. Front Pharmacol. 2021 Jun 21;12:684162. doi: 10.3389/fphar.2021.684162. eCollection 2021. Front Pharmacol. 2021. PMID: 34234675 Free PMC article. Review.

42

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01.

Ogese MO, Lister A, Gardner J, Meng X, Alfirevic A, Pirmohamed M, Park BK, Naisbitt DJ. Ogese MO, et al. Toxicol Sci. 2021 Aug 30;183(1):139-153. doi: 10.1093/toxsci/kfab084. Toxicol Sci. 2021. PMID: 34175955 Free PMC article.

43

Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume.

Thompson A, King K, Morris AP, Pirmohamed M. Thompson A, et al. Hum Mol Genet. 2021 Oct 13;30(21):2040-2051. doi: 10.1093/hmg/ddab147. Hum Mol Genet. 2021. PMID: 34104963 Free PMC article.

44

T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab.

Hammond S, Olsson-Brown A, Gardner J, Thomson P, Ali SE, Jolly C, Carr D, Ressel L, Pirmohamed M, Naisbitt D. Hammond S, et al. J Immunother Cancer. 2021 May;9(5):e002521. doi: 10.1136/jitc-2021-002521. J Immunother Cancer. 2021. PMID: 34049931 Free PMC article.

45

HLA-B*13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients.

Satapornpong P, Pratoomwun J, Rerknimitr P, Klaewsongkram J, Nakkam N, Rungrotmongkol T, Konyoung P, Saksit N, Mahakkanukrauh A, Amornpinyo W, Khunarkornsiri U, Tempark T, Wantavornprasert K, Jinda P, Koomdee N, Jantararoungtong T, Rerkpattanapipat T, Wang CW, Naisbitt D, Tassaneeyakul W, Ariyachaipanich M, Roonghiranwat T, Pirmohamed M, Chung WH, Sukasem C. Satapornpong P, et al. Front Immunol. 2021 May 4;12:661135. doi: 10.3389/fimmu.2021.661135. eCollection 2021. Front Immunol. 2021. PMID: 34017337 Free PMC article.

46

Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01.

Pratoomwun J, Thomson P, Jaruthamsophon K, Tiyasirichokchai R, Jinda P, Rerkpattanapipat T, Tassaneeyakul W, Nakkam N, Rerknimitr P, Klaewsongkram J, Srinoulprasert Y, Pirmohamed M, Naisbitt DJ, Sukasem C. Pratoomwun J, et al. Front Immunol. 2021 Apr 29;12:658593. doi: 10.3389/fimmu.2021.658593. eCollection 2021. Front Immunol. 2021. PMID: 33995375 Free PMC article.

47

Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.

Chan BKY, Elmasry M, Forootan SS, Russomanno G, Bunday TM, Zhang F, Brillant N, Starkey Lewis PJ, Aird R, Ricci E, Andrews TD, Sison-Young RL, Schofield AL, Fang Y, Lister A, Sharkey JW, Poptani H, Kitteringham NR, Forbes SJ, Malik HZ, Fenwick SW, Park BK, Goldring CE, Copple IM. Chan BKY, et al. Hepatology. 2021 Aug;74(2):973-986. doi: 10.1002/hep.31859. Epub 2021 Jul 13. Hepatology. 2021. PMID: 33872408

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HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry.

Konte B, Walters JTR, Rujescu D, Legge SE, Pardiñas AF, Cohen D, Pirmohamed M, Tiihonen J, Hartmann AM, Bogers JP, van der Weide J, van der Weide K, Putkonen A, Repo-Tiihonen E, Hallikainen T, Silva E, Ingimarsson O, Sigurdsson E, Kennedy JL, Sullivan PF, Rietschel M, Breen G, Stefansson H, Stefansson K, Collier DA, O'Donovan MC, Giegling I. Konte B, et al. Transl Psychiatry. 2021 Apr 12;11(1):214. doi: 10.1038/s41398-021-01322-w. Transl Psychiatry. 2021. PMID: 33846298 Free PMC article.

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T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses.

Ogbe A, Kronsteiner B, Skelly DT, Pace M, Brown A, Adland E, Adair K, Akhter HD, Ali M, Ali SE, Angyal A, Ansari MA, Arancibia-Cárcamo CV, Brown H, Chinnakannan S, Conlon C, de Lara C, de Silva T, Dold C, Dong T, Donnison T, Eyre D, Flaxman A, Fletcher H, Gardner J, Grist JT, Hackstein CP, Jaruthamsophon K, Jeffery K, Lambe T, Lee L, Li W, Lim N, Matthews PC, Mentzer AJ, Moore SC, Naisbitt DJ, Ogese M, Ogg G, Openshaw P, Pirmohamed M, Pollard AJ, Ramamurthy N, Rongkard P, Rowland-Jones S, Sampson O, Screaton G, Sette A, Stafford L, Thompson C, Thomson PJ, Thwaites R, Vieira V, Weiskopf D, Zacharopoulou P; Oxford Immunology Network Covid-19 Response T Cell Consortium; Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical Team; Turtle L, Klenerman P, Goulder P, Frater J, Barnes E, Dunachie S. Ogbe A, et al. Nat Commun. 2021 Apr 6;12(1):2055. doi: 10.1038/s41467-021-21856-3. Nat Commun. 2021. PMID: 33824342 Free PMC article.

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HLA Class-II‒Restricted CD8⁺ T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients.

Zhao Q, Almutairi M, Tailor A, Lister A, Harper N, Line J, Meng X, Pratoomwun J, Jaruthamsophon K, Sukasem C, Sun Y, Sun L, Ogese MO, MacEwan DJ, Pirmohamed M, Liu J, Ostrov DA, Liu H, Zhang F, Naisbitt DJ. Zhao Q, et al. J Invest Dermatol. 2021 Oct;141(10):2412-2425.e2. doi: 10.1016/j.jid.2021.03.014. Epub 2021 Mar 30. J Invest Dermatol. 2021. PMID: 33798536 Free article.

51

Inflammatory Bowel Disease: A Personalized Approach.

Konidari A, Dickens D, Pirmohamed M. Konidari A, et al. Front Pediatr. 2021 Feb 11;8:620545. doi: 10.3389/fped.2020.620545. eCollection 2020. Front Pediatr. 2021. PMID: 33643966 Free PMC article. No abstract available.

52

The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy.

Magavern EF, Kaski JC, Turner RM, Drexel H, Janmohamed A, Scourfield A, Burrage D, Floyd CN, Adeyeye E, Tamargo J, Lewis BS, Kjeldsen KP, Niessner A, Wassmann S, Sulzgruber P, Borry P, Agewall S, Semb AG, Savarese G, Pirmohamed M, Caulfield MJ. Magavern EF, et al. Eur Heart J Cardiovasc Pharmacother. 2022 Jan 5;8(1):85-99. doi: 10.1093/ehjcvp/pvab018. Eur Heart J Cardiovasc Pharmacother. 2022. PMID: 33638977 Free PMC article.

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Haematological malignancy and nosocomial transmission are associated with an increased risk of death from COVID-19: results of a multi-center UK cohort.

Bhogal T, Khan UT, Lee R, Stockdale A, Hesford C, Potti-Dhananjaya V, Jathanna A, Rahman S, Tivey A, Shotton R, Sundar R, Valerio C, Norouzi A, Walker P, Suckling R, Armstrong A, Brearton G, Pettitt A, Kalakonda N, Palmer DH, Jackson R, Turtle L, Palmieri C. Bhogal T, et al. Leuk Lymphoma. 2021 Jul;62(7):1682-1691. doi: 10.1080/10428194.2021.1876865. Epub 2021 Jan 28. Leuk Lymphoma. 2021. PMID: 33508995 Free article.

54

Examining the uptake of predictive BRCA testing in the UK; findings and implications.

Martin AP, Downing J, Collins B, Godman B, Alfirevic A, Greenhalgh KL, Pirmohamed M. Martin AP, et al. Eur J Hum Genet. 2021 Apr;29(4):699-708. doi: 10.1038/s41431-020-00783-9. Epub 2020 Dec 16. Eur J Hum Genet. 2021. PMID: 33328582 Free PMC article.

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Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex.

Patel W, Rimmer L, Smith M, Moss L, Smith MA, Snodgrass HR, Pirmohamed M, Alfirevic A, Dickens D. Patel W, et al. Mol Pharm. 2021 Jan 4;18(1):113-123. doi: 10.1021/acs.molpharmaceut.0c00727. Epub 2020 Dec 13. Mol Pharm. 2021. PMID: 33307708

56

Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use.

Hernandez-Pacheco N, Vijverberg SJ, Herrera-Luis E, Li J, Sio YY, Granell R, Corrales A, Maroteau C, Lethem R, Perez-Garcia J, Farzan N, Repnik K, Gorenjak M, Soares P, Karimi L, Schieck M, Pérez-Méndez L, Berce V, Tavendale R, Eng C, Sardon O, Kull I, Mukhopadhyay S, Pirmohamed M, Verhamme KMC, Burchard EG, Kabesch M, Hawcutt DB, Melén E, Potočnik U, Chew FT, Tantisira KG, Turner S, Palmer CN, Flores C, Pino-Yanes M, Maitland-van der Zee AH; PiCA and SysPharmPedia consortia. Hernandez-Pacheco N, et al. Eur Respir J. 2021 May 13;57(5):2003388. doi: 10.1183/13993003.03388-2020. Print 2021 May. Eur Respir J. 2021. PMID: 33303529 Free PMC article.

57

Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda.

Asiimwe IG, Waitt C, Sekaggya-Wiltshire C, Hutchinson C, Okello E, Zhang EJ, Semakula JR, Mouton JP, Cohen K, Blockman M, Lamorde M, Jorgensen AL, Pirmohamed M. Asiimwe IG, et al. Clin Pharmacol Ther. 2021 Jun;109(6):1564-1574. doi: 10.1002/cpt.2128. Epub 2020 Dec 28. Clin Pharmacol Ther. 2021. PMID: 33280090

58

Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study.

Turner RM, de Koning EM, Fontana V, Thompson A, Pirmohamed M. Turner RM, et al. BMC Med. 2020 Nov 25;18(1):367. doi: 10.1186/s12916-020-01827-z. BMC Med. 2020. PMID: 33234119 Free PMC article.

59

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine.

Yip VLM, Pertinez H, Meng X, Maggs JL, Carr DF, Park BK, Marson AG, Pirmohamed M. Yip VLM, et al. Br J Clin Pharmacol. 2021 Jun;87(6):2572-2588. doi: 10.1111/bcp.14667. Epub 2020 Dec 14. Br J Clin Pharmacol. 2021. PMID: 33217013 Free PMC article.

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Pharmacogenomics for Primary Care: An Overview.

Rollinson V, Turner R, Pirmohamed M. Rollinson V, et al. Genes (Basel). 2020 Nov 12;11(11):1337. doi: 10.3390/genes11111337. Genes (Basel). 2020. PMID: 33198260 Free PMC article. Review.

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Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury.

Waddington JC, Ali SE, Penman SL, Whitaker P, Hamlett J, Chadwick A, Naisbitt DJ, Park BK, Meng X. Waddington JC, et al. Chem Res Toxicol. 2020 Dec 21;33(12):2939-2943. doi: 10.1021/acs.chemrestox.0c00400. Epub 2020 Nov 10. Chem Res Toxicol. 2020. PMID: 33169987

62

Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens.

Nicoletti P, Devarbhavi H, Goel A, Venkatesan R, Eapen CE, Grove JI, Zafer S, Bjornsson E, Lucena MI, Andrade RJ, Pirmohamed M, Wadelius M, Larrey D, Maitland-van der Zee AH, Ibanez L, Watkins PB, Daly AK, Aithal GP. Nicoletti P, et al. Clin Pharmacol Ther. 2021 Apr;109(4):1125-1135. doi: 10.1002/cpt.2100. Epub 2020 Dec 5. Clin Pharmacol Ther. 2021. PMID: 33135175 Free article.

63

Dimethyl fumarate induced lymphopenia in multiple sclerosis: A review of the literature.

Dello Russo C, Scott KA, Pirmohamed M. Dello Russo C, et al. Pharmacol Ther. 2021 Mar;219:107710. doi: 10.1016/j.pharmthera.2020.107710. Epub 2020 Oct 20. Pharmacol Ther. 2021. PMID: 33091427 Review.

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Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort.

Nicoletti P, Carr DF, Barrett S, McEvoy L, Friedmann PS, Shear NH, Nelson MR, Chiriac AM, Blanca-López N, Cornejo-García JA, Gaeta F, Nakonechna A, Torres MJ, Caruso C, Valluzzi RL, Floratos A, Shen Y, Pavlos RK, Phillips EJ, Demoly P, Romano A, Blanca M, Pirmohamed M. Nicoletti P, et al. J Allergy Clin Immunol. 2021 May;147(5):1830-1837.e15. doi: 10.1016/j.jaci.2020.10.004. Epub 2020 Oct 13. J Allergy Clin Immunol. 2021. PMID: 33058932 Free PMC article.

65

Characterization of Clozapine-Responsive Human T Cells.

Ogese MO, Lister A, Jenkins RE, Meng X, Alfirevic A, Douglas L, Mcloughlin R, Silva E, Park BK, Pirmohamed M, Naisbitt DJ. Ogese MO, et al. J Immunol. 2020 Nov 1;205(9):2375-2390. doi: 10.4049/jimmunol.2000646. Epub 2020 Sep 28. J Immunol. 2020. PMID: 32989092

66

CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1.

Meng X, Waddington JC, Tailor A, Lister A, Hamlett J, Berry N, Park BK, Sporn MB. Meng X, et al. J Med Chem. 2020 Sep 10;63(17):9965-9976. doi: 10.1021/acs.jmedchem.0c01088. Epub 2020 Aug 19. J Med Chem. 2020. PMID: 32787104

67

HLA DRB1*15:01-DQB1*06:02-Restricted Human CD4+ T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts.

Tailor A, Meng X, Adair K, Farrell J, Waddington JC, Daly A, Pirmohamed M, Dear G, Park BK, Naisbitt DJ. Tailor A, et al. Toxicol Sci. 2020 Nov 1;178(1):115-126. doi: 10.1093/toxsci/kfaa128. Toxicol Sci. 2020. PMID: 32777075

68

Safety perspectives on presently considered drugs for the treatment of COVID-19.

Penman SL, Kiy RT, Jensen RL, Beoku-Betts C, Alfirevic A, Back D, Khoo SH, Owen A, Pirmohamed M, Park BK, Meng X, Goldring CE, Chadwick AE. Penman SL, et al. Br J Pharmacol. 2020 Oct;177(19):4353-4374. doi: 10.1111/bph.15204. Epub 2020 Aug 13. Br J Pharmacol. 2020. PMID: 32681537 Free PMC article. Review.

69

A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments.

Baker EH, Gnjidic D, Kirkpatrick CMJ, Pirmohamed M, Wright DFB, Zecharia AY. Baker EH, et al. Br J Clin Pharmacol. 2021 Mar;87(3):707-711. doi: 10.1111/bcp.14416. Epub 2020 Jun 19. Br J Clin Pharmacol. 2021. PMID: 32515023 Free article. No abstract available.

70

Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response.

Carr DF, Turner RM, Pirmohamed M. Carr DF, et al. Br J Clin Pharmacol. 2021 Feb;87(2):237-255. doi: 10.1111/bcp.14407. Epub 2020 Jun 30. Br J Clin Pharmacol. 2021. PMID: 32501544 Free article. Review.

71

Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients.

Davies A, Rodriguez-Vicente AE, Austin G, Loaiza S, Foroni L, Clark RE, Pirmohamed M. Davies A, et al. Sci Rep. 2020 May 21;10(1):8394. doi: 10.1038/s41598-020-65350-0. Sci Rep. 2020. PMID: 32439979 Free PMC article. Clinical Trial.

72

Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study.

van der Wouden CH, Böhringer S, Cecchin E, Cheung KC, Dávila-Fajardo CL, Deneer VHM, Dolžan V, Ingelman-Sundberg M, Jönsson S, Karlsson MO, Kriek M, Mitropoulou C, Patrinos GP, Pirmohamed M, Rial-Sebbag E, Samwald M, Schwab M, Steinberger D, Stingl J, Sunder-Plassmann G, Toffoli G, Turner RM, van Rhenen MH, van Zwet E, Swen JJ, Guchelaar HJ; Ubiquitous Pharmacogenomics Consortium. van der Wouden CH, et al. Pharmacogenet Genomics. 2020 Aug;30(6):131-144. doi: 10.1097/FPC.0000000000000405. Pharmacogenet Genomics. 2020. PMID: 32317559 Free PMC article.

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SJS/TEN 2019: From science to translation.

Chang WC, Abe R, Anderson P, Anderson W, Ardern-Jones MR, Beachkofsky TM, Bellón T, Biala AK, Bouchard C, Cavalleri GL, Chapman N, Chodosh J, Choi HK, Cibotti RR, Divito SJ, Dewar K, Dehaeck U, Etminan M, Forbes D, Fuchs E, Goldman JL, Holmes JH 4th, Hope EA, Hung SI, Hsieh CL, Iovieno A, Jagdeo J, Kim MK, Koelle DM, Lacouture ME, Le Pallec S, Lehloenya RJ, Lim R, Lowe A, McCawley J, McCawley J, Micheletti RG, Mockenhaupt M, Niemeyer K, Norcross MA, Oboh D, Olteanu C, Pasieka HB, Peter J, Pirmohamed M, Rieder M, Saeed HN, Shear NH, Shieh C, Straus S, Sukasem C, Sung C, Trubiano JA, Tsou SY, Ueta M, Volpi S, Wan C, Wang H, Wang ZQ, Weintraub J, Whale C, Wheatley LM, Whyte-Croasdaile S, Williams KB, Wright G, Yeung SN, Zhou L, Chung WH, Phillips EJ, Carleton BC. Chang WC, et al. J Dermatol Sci. 2020 Apr;98(1):2-12. doi: 10.1016/j.jdermsci.2020.02.003. Epub 2020 Mar 7. J Dermatol Sci. 2020. PMID: 32192826 Free PMC article.

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Two distinct clinical patterns of checkpoint inhibitor-induced thyroid dysfunction.

Olsson-Brown A, Lord R, Sacco J, Wagg J, Coles M, Pirmohamed M. Olsson-Brown A, et al. Endocr Connect. 2020 Apr;9(4):318-325. doi: 10.1530/EC-19-0473. Endocr Connect. 2020. PMID: 32163916 Free PMC article.

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Author Correction: A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.

McWilliam SJ, Rosala-Hallas A, Jones AP, Shaw V, Greenhalf W, Jaki T, Smyth AR, Smyth RL, Pirmohamed M. McWilliam SJ, et al. Sci Rep. 2020 Mar 10;10(1):4730. doi: 10.1038/s41598-020-61783-9. Sci Rep. 2020. PMID: 32152372 Free PMC article.

76

Seizures and quinolone antibiotics in children: a systematic review of adverse events.

Neame M, King C, Riordan A, Iyer A, Kneen R, Sinha I, Hawcutt DB. Neame M, et al. Eur J Hosp Pharm. 2020 Mar;27(2):60-64. doi: 10.1136/ejhpharm-2018-001805. Epub 2019 Jan 28. Eur J Hosp Pharm. 2020. PMID: 32133130 Free PMC article.

77

Predicting the safety of medicines in pregnancy: A workshop report.

Clements JM, Hawkes RG, Jones D, Adjei A, Chambers T, Simon L, Stemplewski H, Berry N, Price S, Pirmohamed M, Piersma AH, Waxenecker G, Barrow P, Beekhuijzen MEW, Fowkes A, Prior H, Sewell F. Clements JM, et al. Reprod Toxicol. 2020 Apr;93:199-210. doi: 10.1016/j.reprotox.2020.02.011. Epub 2020 Feb 29. Reprod Toxicol. 2020. PMID: 32126282 Free article.

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Genetic associations with clozapine-induced myocarditis in patients with schizophrenia.

Lacaze P, Ronaldson KJ, Zhang EJ, Alfirevic A, Shah H, Newman L, Strahl M, Smith M, Bousman C, Francis B, Morris AP, Wilson T, Rossello F, Powell D, Vasic V, Sebra R, McNeil JJ, Pirmohamed M. Lacaze P, et al. Transl Psychiatry. 2020 Jan 27;10(1):37. doi: 10.1038/s41398-020-0722-0. Transl Psychiatry. 2020. PMID: 32066683 Free PMC article.

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Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B alleles.

Ramsbottom KA, Carr DF, Rigden DJ, Jones AR. Ramsbottom KA, et al. PLoS One. 2020 Feb 6;15(2):e0220754. doi: 10.1371/journal.pone.0220754. eCollection 2020. PLoS One. 2020. PMID: 32027661 Free PMC article.

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Biomarker-guided trials: Challenges in practice.

Antoniou M, Kolamunnage-Dona R, Wason J, Bathia R, Billingham C, Bliss JM, Brown LC, Gillman A, Paul J, Jorgensen AL. Antoniou M, et al. Contemp Clin Trials Commun. 2019 Nov 16;16:100493. doi: 10.1016/j.conctc.2019.100493. eCollection 2019 Dec. Contemp Clin Trials Commun. 2019. PMID: 31788574 Free PMC article.

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NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells.

Jones LG, Vaida A, Thompson LM, Ikuomola FI, Caamaño JH, Burkitt MD, Miyajima F, Williams JM, Campbell BJ, Pritchard DM, Duckworth CA. Jones LG, et al. Cell Death Dis. 2019 Nov 26;10(12):896. doi: 10.1038/s41419-019-2129-5. Cell Death Dis. 2019. PMID: 31772152 Free PMC article.

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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.

Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK. Weaver RJ, et al. Nat Rev Drug Discov. 2020 Feb;19(2):131-148. doi: 10.1038/s41573-019-0048-x. Epub 2019 Nov 20. Nat Rev Drug Discov. 2020. PMID: 31748707 Free article. Review.

83

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.

Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF. Chenoweth MJ, et al. Clin Pharmacol Ther. 2020 Jan;107(1):57-61. doi: 10.1002/cpt.1664. Epub 2019 Nov 6. Clin Pharmacol Ther. 2020. PMID: 31696505 Free PMC article. No abstract available.

84

T-Cell Activation by Low Molecular Weight Drugs and Factors That Influence Susceptibility to Drug Hypersensitivity.

Hammond S, Thomson PJ, Ogese MO, Naisbitt DJ. Hammond S, et al. Chem Res Toxicol. 2020 Jan 21;33(1):77-94. doi: 10.1021/acs.chemrestox.9b00327. Epub 2019 Nov 20. Chem Res Toxicol. 2020. PMID: 31687800 Review.

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Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury.

Ali SE, Waddington JC, Park BK, Meng X. Ali SE, et al. Chem Res Toxicol. 2020 Jan 21;33(1):61-76. doi: 10.1021/acs.chemrestox.9b00275. Epub 2019 Nov 14. Chem Res Toxicol. 2020. PMID: 31682113 Review.

86

Critical considerations for targeting colorectal liver metastases with nanotechnology.

Arshad U, Sutton PA, Ashford MB, Treacher KE, Liptrott NJ, Rannard SP, Goldring CE, Owen A. Arshad U, et al. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Mar;12(2):e1588. doi: 10.1002/wnan.1588. Epub 2019 Sep 30. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020. PMID: 31566913 Free PMC article. Review.

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Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation.

Thomson PJ, Illing PT, Farrell J, Alhaidari M, Bell CC, Berry N, O'Neill PM, Purcell AW, Park KB, Naisbitt DJ. Thomson PJ, et al. Allergy. 2020 Mar;75(3):636-647. doi: 10.1111/all.14057. Epub 2019 Oct 9. Allergy. 2020. PMID: 31549414

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Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study).

Waitt C, Orrell C, Walimbwa S, Singh Y, Kintu K, Simmons B, Kaboggoza J, Sihlangu M, Coombs JA, Malaba T, Byamugisha J, Amara A, Gini J, Else L, Heiburg C, Hodel EM, Reynolds H, Mehta U, Byakika-Kibwika P, Hill A, Myer L, Lamorde M, Khoo S. Waitt C, et al. PLoS Med. 2019 Sep 20;16(9):e1002895. doi: 10.1371/journal.pmed.1002895. eCollection 2019 Sep. PLoS Med. 2019. PMID: 31539371 Free PMC article. Clinical Trial.

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Measuring Kidney Perfusion, pH, and Renal Clearance Consecutively Using MRI and Multispectral Optoacoustic Tomography.

Minhas AS, Sharkey J, Randtke EA, Murray P, Wilm B, Pagel MD, Poptani H. Minhas AS, et al. Mol Imaging Biol. 2020 Jun;22(3):494-503. doi: 10.1007/s11307-019-01429-z. Mol Imaging Biol. 2020. PMID: 31529408 Free PMC article.

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The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics.

Shaw HA, Preston MD, Vendrik KEW, Cairns MD, Browne HP, Stabler RA, Crobach MJT, Corver J, Pituch H, Ingebretsen A, Pirmohamed M, Faulds-Pain A, Valiente E, Lawley TD, Fairweather NF, Kuijper EJ, Wren BW. Shaw HA, et al. Clin Microbiol Infect. 2020 Apr;26(4):492-498. doi: 10.1016/j.cmi.2019.09.004. Epub 2019 Sep 13. Clin Microbiol Infect. 2020. PMID: 31525517 Free PMC article.

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Genetic Predisposition to Anticonvulsant Hypersensitivity.

Pirmohamed M. Pirmohamed M. Clin Pharmacol Ther. 2019 Nov;106(5):919-922. doi: 10.1002/cpt.1610. Epub 2019 Sep 13. Clin Pharmacol Ther. 2019. PMID: 31517995 No abstract available.

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Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials.

Johnson D, Hughes D, Pirmohamed M, Jorgensen A. Johnson D, et al. J Pers Med. 2019 Sep 1;9(3):42. doi: 10.3390/jpm9030042. J Pers Med. 2019. PMID: 31480618 Free PMC article. Review.

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Definition of Haptens Derived from Sulfamethoxazole: In Vitro and in Vivo.

Tailor A, Waddington JC, Hamlett J, Maggs J, Kafu L, Farrell J, Dear GJ, Whitaker P, Naisbitt DJ, Park K, Meng X. Tailor A, et al. Chem Res Toxicol. 2019 Oct 21;32(10):2095-2106. doi: 10.1021/acs.chemrestox.9b00282. Epub 2019 Sep 11. Chem Res Toxicol. 2019. PMID: 31468968

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Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial.

Sevene E, Banda CG, Mukaka M, Maculuve S, Macuacua S, Vala A, Piqueras M, Kalilani-Phiri L, Mallewa J, Terlouw DJ, Khoo SH, Lalloo DG, Mwapasa V. Sevene E, et al. Malar J. 2019 Aug 20;18(1):277. doi: 10.1186/s12936-019-2909-5. Malar J. 2019. PMID: 31429785 Free PMC article. Clinical Trial.

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Adaptation of host transmission cycle during Clostridium difficile speciation.

Kumar N, Browne HP, Viciani E, Forster SC, Clare S, Harcourt K, Stares MD, Dougan G, Fairley DJ, Roberts P, Pirmohamed M, Clokie MRJ, Jensen MBF, Hargreaves KR, Ip M, Wieler LH, Seyboldt C, Norén T, Riley TV, Kuijper EJ, Wren BW, Lawley TD. Kumar N, et al. Nat Genet. 2019 Sep;51(9):1315-1320. doi: 10.1038/s41588-019-0478-8. Epub 2019 Aug 12. Nat Genet. 2019. PMID: 31406348

96

Public involvement in the dissemination of the North West Coast Household Health Survey: Experiences and lessons of co-producing research together.

Giebel C, Hassan S, McIntyre JC, Corcoran R, Barr B, Gabbay M, Downing J, Comerford T, Alfirevic A. Giebel C, et al. Health Expect. 2019 Aug;22(4):643-649. doi: 10.1111/hex.12940. Epub 2019 Jul 29. Health Expect. 2019. PMID: 31355516 Free PMC article.

97

Long-Acting Injectable Statins-Is It Time for a Paradigm Shift?

Tatham LM, Liptrott NJ, Rannard SP, Owen A. Tatham LM, et al. Molecules. 2019 Jul 24;24(15):2685. doi: 10.3390/molecules24152685. Molecules. 2019. PMID: 31344834 Free PMC article.

98

Genetic testing for prevention of severe drug-induced skin rash.

Alfirevic A, Pirmohamed M, Marinovic B, Harcourt-Smith L, Jorgensen AL, Cooper TE. Alfirevic A, et al. Cochrane Database Syst Rev. 2019 Jul 17;7(7):CD010891. doi: 10.1002/14651858.CD010891.pub2. Cochrane Database Syst Rev. 2019. PMID: 31314143 Free PMC article.

99

Protocol for the development of the STrengthening the Reporting Of Pharmacogenetic Studies (STROPS) guideline: checklist of items for reporting pharmacogenetic studies.

Richardson M, Kirkham JJ, Dwan KM, Sloan DJ, Davies G, Jorgensen A. Richardson M, et al. BMJ Open. 2019 Jul 11;9(7):e030212. doi: 10.1136/bmjopen-2019-030212. BMJ Open. 2019. PMID: 31300508 Free PMC article.

100

Optimizing responses to drug safety signals in pregnancy: the example of dolutegravir and neural tube defects.

Mofenson LM, Pozniak AL, Wambui J, Raizes E, Ciaranello A, Clayden P, Ehrenkranz P, Fakoya A, Hill A, Khoo S, Mahaka I, Modi S, Moore C, Phillips A, Siberry G, Sikwese K, Thorne C, Watts HD, Doherty M, Ford NP. Mofenson LM, et al. J Int AIDS Soc. 2019 Jul;22(7):e25352. doi: 10.1002/jia2.25352. J Int AIDS Soc. 2019. PMID: 31298496 Free PMC article.

101

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells.

Penman SL, Sharma P, Aerts H, Park BK, Weaver RJ, Chadwick AE. Penman SL, et al. Toxicol In Vitro. 2019 Dec;61:104595. doi: 10.1016/j.tiv.2019.104595. Epub 2019 Jul 6. Toxicol In Vitro. 2019. PMID: 31288073 Free PMC article.

102

Dose-linearity of the pharmacokinetics of an intravenous [¹⁴ C]midazolam microdose in children.

van Groen BD, Vaes WH, Park BK, Krekels EHJ, van Duijn E, Kõrgvee LT, Maruszak W, Grynkiewicz G, Garner RC, Knibbe CAJ, Tibboel D, de Wildt SN, Turner MA. van Groen BD, et al. Br J Clin Pharmacol. 2019 Oct;85(10):2332-2340. doi: 10.1111/bcp.14047. Epub 2019 Jul 30. Br J Clin Pharmacol. 2019. PMID: 31269280 Free PMC article.

103

International and multidisciplinary scientific collaborations and networks are advancing knowledge about Stevens-Johnson syndrome and toxic epidermal necrolysis.

Dodiuk-Gad RP. Dodiuk-Gad RP. Br J Dermatol. 2019 Jul;181(1):18-19. doi: 10.1111/bjd.17863. Br J Dermatol. 2019. PMID: 31259394 No abstract available.

104

Correction to: Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement.

Goldman JL, Chung WH, Lee BR, Chen CB, Lu CW, Hoetzenecker W, Micheletti R, Yasuda SU, Margolis DJ, Shear NH, Struewing JP, Pirmohamed M. Goldman JL, et al. Eur J Clin Pharmacol. 2019 Sep;75(9):1331. doi: 10.1007/s00228-019-02710-4. Eur J Clin Pharmacol. 2019. PMID: 31254013

105

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.

Floyd JS, Bloch KM, Brody JA, Maroteau C, Siddiqui MK, Gregory R, Carr DF, Molokhia M, Liu X, Bis JC, Ahmed A, Liu X, Hallberg P, Yue QY, Magnusson PKE, Brisson D, Wiggins KL, Morrison AC, Khoury E, McKeigue P, Stricker BH, Lapeyre-Mestre M, Heckbert SR, Gallagher AM, Chinoy H, Gibbs RA, Bondon-Guitton E, Tracy R, Boerwinkle E, Gaudet D, Conforti A, van Staa T, Sitlani CM, Rice KM, Maitland-van der Zee AH, Wadelius M, Morris AP, Pirmohamed M, Palmer CAN, Psaty BM, Alfirevic A; PREDICTION-ADR Consortium and EUDRAGENE. Floyd JS, et al. PLoS One. 2019 Jun 26;14(6):e0218115. doi: 10.1371/journal.pone.0218115. eCollection 2019. PLoS One. 2019. PMID: 31242253 Free PMC article.

106

Educating the Next Generation of Pharmacogenomics Experts: Global Educational Needs and Concepts.

Just KS, Turner RM, Dolžan V, Cecchin E, Swen JJ, Gurwitz D, Stingl JC. Just KS, et al. Clin Pharmacol Ther. 2019 Aug;106(2):313-316. doi: 10.1002/cpt.1471. Epub 2019 Jun 25. Clin Pharmacol Ther. 2019. PMID: 31237679 Free PMC article. No abstract available.

107

Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink.

Carr DF, Francis B, Jorgensen AL, Zhang E, Chinoy H, Heckbert SR, Bis JC, Brody JA, Floyd JS, Psaty BM, Molokhia M, Lapeyre-Mestre M, Conforti A, Alfirevic A, van Staa T, Pirmohamed M. Carr DF, et al. Clin Pharmacol Ther. 2019 Dec;106(6):1353-1361. doi: 10.1002/cpt.1557. Epub 2019 Jul 31. Clin Pharmacol Ther. 2019. PMID: 31220337 Free PMC article.

108

Reply to Banda et al., "Interpretation of Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine".

Walimbwa S, Lamorde M, Waitt C, Amara A, Khoo S. Walimbwa S, et al. Antimicrob Agents Chemother. 2019 May 24;63(6):e00593-19. doi: 10.1128/AAC.00593-19. Print 2019 Jun. Antimicrob Agents Chemother. 2019. PMID: 31126921 Free PMC article. No abstract available.

109

Efficacy and safety of artemether-lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: an open label non-randomized interventional trial.

Banda CG, Chaponda M, Mukaka M, Mulenga M, Hachizovu S, Kabuya JB, Mulenga J, Sikalima J, Kalilani-Phiri L, Terlouw DJ, Khoo SH, Lalloo DG, Mwapasa V. Banda CG, et al. Malar J. 2019 May 24;18(1):180. doi: 10.1186/s12936-019-2818-7. Malar J. 2019. PMID: 31126288 Free PMC article. Clinical Trial.

110

Fifteen-minute consultation: Pharmacogenomics: a guide for busy clinicians.

Parry CM, Hawcutt D. Parry CM, et al. Arch Dis Child Educ Pract Ed. 2020 Apr;105(2):107-110. doi: 10.1136/archdischild-2019-316971. Epub 2019 May 15. Arch Dis Child Educ Pract Ed. 2020. PMID: 31092398 Review.

111

Exosomal Transport of Hepatocyte-Derived Drug-Modified Proteins to the Immune System.

Ogese MO, Jenkins RE, Adair K, Tailor A, Meng X, Faulkner L, Enyindah BO, Schofield A, Diaz-Nieto R, Ressel L, Eagle GL, Kitteringham NR, Goldring CE, Park BK, Naisbitt DJ, Betts C. Ogese MO, et al. Hepatology. 2019 Nov;70(5):1732-1749. doi: 10.1002/hep.30701. Epub 2019 Jun 29. Hepatology. 2019. PMID: 31070244 Free PMC article.

112

Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.

Nicoletti P, Barrett S, McEvoy L, Daly AK, Aithal G, Lucena MI, Andrade RJ, Wadelius M, Hallberg P, Stephens C, Bjornsson ES, Friedmann P, Kainu K, Laitinen T, Marson A, Molokhia M, Phillips E, Pichler W, Romano A, Shear N, Sills G, Tanno LK, Swale A, Floratos A, Shen Y, Nelson MR, Watkins PB, Daly MJ, Morris AP, Alfirevic A, Pirmohamed M. Nicoletti P, et al. Clin Pharmacol Ther. 2019 Nov;106(5):1028-1036. doi: 10.1002/cpt.1493. Epub 2019 Jul 3. Clin Pharmacol Ther. 2019. PMID: 31066027 Free PMC article.

113

Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity.

Kamalian L, Douglas O, Jolly CE, Snoeys J, Simic D, Monshouwer M, Williams DP, Park BK, Chadwick AE. Kamalian L, et al. Curr Protoc Toxicol. 2019 Jun;80(1):e76. doi: 10.1002/cptx.76. Epub 2019 May 6. Curr Protoc Toxicol. 2019. PMID: 31058461

114

Trends in BRCA testing and socioeconomic deprivation.

Martin AP, Pedra G, Downing J, Collins B, Godman B, Alfirevic A, Pirmohamed M, Lynn Greenhalgh K. Martin AP, et al. Eur J Hum Genet. 2019 Sep;27(9):1351-1360. doi: 10.1038/s41431-019-0424-3. Epub 2019 May 3. Eur J Hum Genet. 2019. PMID: 31053786 Free PMC article.

115

Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics.

Fitzgerald G, Prince C, Downing J, Reynolds J, Zhang JE, Hanson A, Alfirevic A, Pirmohamed M. Fitzgerald G, et al. Pharmacogenomics. 2019 Jun;20(8):599-608. doi: 10.2217/pgs-2019-0021. Epub 2019 May 3. Pharmacogenomics. 2019. PMID: 31046595 Free article. No abstract available.

116

HLA- and immune-mediated adverse drug reactions: Another hit with vancomycin.

Pirmohamed M. Pirmohamed M. J Allergy Clin Immunol. 2019 Jul;144(1):44-45. doi: 10.1016/j.jaci.2019.04.009. Epub 2019 Apr 25. J Allergy Clin Immunol. 2019. PMID: 31029771 No abstract available.

117

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.

Thaventhiran T, Wong W, Alghanem AF, Alhumeed N, Aljasir MA, Ramsey S, Sethu S, Yeang HXA, Chadwick AE, Cross M, Webb SD, Djouhri L, Ball C, Stebbings R, Sathish JG. Thaventhiran T, et al. Monoclon Antib Immunodiagn Immunother. 2019 Apr;38(2):60-69. doi: 10.1089/mab.2018.0042. Monoclon Antib Immunodiagn Immunother. 2019. PMID: 31009338 Free PMC article.

118

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism.

Kelly RA, Leedale J, Calleja D, Enoch SJ, Harrell A, Chadwick AE, Webb S. Kelly RA, et al. Sci Rep. 2019 Apr 19;9(1):6333. doi: 10.1038/s41598-019-42799-2. Sci Rep. 2019. PMID: 31004119 Free PMC article.

119

Population Pharmacokinetic Modeling of VL-2397, a Novel Systemic Antifungal Agent: Analysis of a Single- and Multiple-Ascending-Dose Study in Healthy Subjects.

Kovanda LL, Sullivan SM, Smith LR, Desai AV, Bonate PL, Hope WW. Kovanda LL, et al. Antimicrob Agents Chemother. 2019 May 24;63(6):e00163-19. doi: 10.1128/AAC.00163-19. Print 2019 Jun. Antimicrob Agents Chemother. 2019. PMID: 30988142 Free PMC article.

120

Stem cell models as an in vitro model for predictive toxicology.

Lynch S, Pridgeon CS, Duckworth CA, Sharma P, Park BK, Goldring CEP. Lynch S, et al. Biochem J. 2019 Apr 15;476(7):1149-1158. doi: 10.1042/BCJ20170780. Biochem J. 2019. PMID: 30988136 Free PMC article. Review.

121

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study.

Jorgensen AL, Prince C, Fitzgerald G, Hanson A, Downing J, Reynolds J, Zhang JE, Alfirevic A, Pirmohamed M. Jorgensen AL, et al. BMC Med. 2019 Apr 8;17(1):76. doi: 10.1186/s12916-019-1308-7. BMC Med. 2019. PMID: 30961588 Free PMC article. Clinical Trial.

122

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy.

Walker LE, Frigerio F, Ravizza T, Ricci E, Tse K, Jenkins RE, Sills GJ, Jorgensen A, Porcu L, Thippeswamy T, Alapirtti T, Peltola J, Brodie MJ, Park BK, Marson AG, Antoine DJ, Vezzani A, Pirmohamed M. Walker LE, et al. J Clin Invest. 2019 Apr 8;129(5):2166. doi: 10.1172/JCI129285. eCollection 2019 Apr 8. J Clin Invest. 2019. PMID: 30958803 Free PMC article. No abstract available.

123

Carbamazepine intervention in a patient with efavirenz-induced liver injury.

Jacobs TG, Burger DM, Pranger AD, Khoo SH, Drenth JPH, van Crevel R. Jacobs TG, et al. AIDS. 2019 May 1;33(6):1097-1098. doi: 10.1097/QAD.0000000000002116. AIDS. 2019. PMID: 30946165 No abstract available.

124

NAT2 variants and toxicity related to anti-tuberculosis agents: a systematic review and meta-analysis.

Richardson M, Kirkham J, Dwan K, Sloan DJ, Davies G, Jorgensen AL. Richardson M, et al. Int J Tuberc Lung Dis. 2019 Mar 1;23(3):293-305. doi: 10.5588/ijtld.18.0324. Int J Tuberc Lung Dis. 2019. PMID: 30871660 Free PMC article.

125

Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01.

Zhao Q, Alhilali K, Alzahrani A, Almutairi M, Amjad J, Liu H, Sun Y, Sun L, Zhang H, Meng X, Gibson A, Ogese MO, Kevin Park B, Liu J, Ostrov DA, Zhang F, Naisbitt DJ. Zhao Q, et al. Allergy. 2019 Aug;74(8):1533-1548. doi: 10.1111/all.13769. Epub 2019 Apr 15. Allergy. 2019. PMID: 30844087 Free PMC article.

126

In vitro Liver Zonation of Primary Rat Hepatocytes.

Tomlinson L, Hyndman L, Firman JW, Bentley R, Kyffin JA, Webb SD, McGinty S, Sharma P. Tomlinson L, et al. Front Bioeng Biotechnol. 2019 Feb 18;7:17. doi: 10.3389/fbioe.2019.00017. eCollection 2019. Front Bioeng Biotechnol. 2019. PMID: 30834246 Free PMC article.

127

Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway.

Tomlinson L, Lu ZQ, Bentley RA, Colley HE, Murdoch C, Webb SD, Cross MJ, Copple IM, Sharma P. Tomlinson L, et al. Biomed Pharmacother. 2019 Apr;112:108637. doi: 10.1016/j.biopha.2019.108637. Epub 2019 Feb 22. Biomed Pharmacother. 2019. PMID: 30798127 Free article.

128

A Comprehensive Framework for Physiologically-Based Pharmacokinetic Modeling in Matlab.

Stader F, Penny MA, Siccardi M, Marzolini C. Stader F, et al. CPT Pharmacometrics Syst Pharmacol. 2019 Jul;8(7):444-459. doi: 10.1002/psp4.12399. Epub 2019 Apr 2. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30779335 Free PMC article.

129

Impact of pharmacogenetics and pregnancy on tenofovir and emtricitabine pharmacokinetics.

Gini J, Olagunju A, Dickinson L, Waitt C, Neary M, Else LJ, Siccardi M, Khoo S. Gini J, et al. Pharmacogenomics. 2019 Mar;20(4):217-223. doi: 10.2217/pgs-2018-0111. Epub 2019 Feb 15. Pharmacogenomics. 2019. PMID: 30767719

130

Therapeutic drug monitoring of darunavir/ritonavir in pregnancy.

Murtagh R, Else LJ, Kuan KB, Khoo SH, Jackson V, Patel A, Lawler M, McDonald G, Le Blanc D, Avramovic G, Redmond N, Lambert JS. Murtagh R, et al. Antivir Ther. 2019;24(3):229-233. doi: 10.3851/IMP3291. Antivir Ther. 2019. PMID: 30728322

131

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma.

Hernandez-Pacheco N, Farzan N, Francis B, Karimi L, Repnik K, Vijverberg SJ, Soares P, Schieck M, Gorenjak M, Forno E, Eng C, Oh SS, Pérez-Méndez L, Berce V, Tavendale R, Samedy LA, Hunstman S, Hu D, Meade K, Farber HJ, Avila PC, Serebrisky D, Thyne SM, Brigino-Buenaventura E, Rodriguez-Cintron W, Sen S, Kumar R, Lenoir M, Rodriguez-Santana JR, Celedón JC, Mukhopadhyay S, Potočnik U, Pirmohamed M, Verhamme KM, Kabesch M, Palmer CNA, Hawcutt DB, Flores C, Maitland-van der Zee AH, Burchard EG, Pino-Yanes M. Hernandez-Pacheco N, et al. Clin Exp Allergy. 2019 Jun;49(6):789-798. doi: 10.1111/cea.13354. Epub 2019 Feb 15. Clin Exp Allergy. 2019. PMID: 30697902 Free PMC article. Clinical Trial.

132

Nilotinib-induced metabolic dysfunction: insights from a translational study using in vitro adipocyte models and patient cohorts.

Sadiq S, Owen E, Foster T, Knight K, Wang L, Pirmohamed M, Clark RE, Pushpakom S. Sadiq S, et al. Leukemia. 2019 Jul;33(7):1810-1814. doi: 10.1038/s41375-018-0337-0. Epub 2019 Jan 28. Leukemia. 2019. PMID: 30692595 Free PMC article. No abstract available.

133

Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli.

Hodgson D, Rowan AD, Falciani F, Proctor CJ. Hodgson D, et al. PLoS Comput Biol. 2019 Jan 24;15(1):e1006685. doi: 10.1371/journal.pcbi.1006685. eCollection 2019 Jan. PLoS Comput Biol. 2019. PMID: 30677026 Free PMC article.

134

Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study.

Hope W, Johnstone G, Cicconi S, Felton T, Goodwin J, Whalley S, Santoyo-Castelazo A, Ramos-Martin V, Lestner J, Credidio L, Dane A, Carr DF, Pirmohamed M, Salim R, Neely M. Hope W, et al. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02353-18. doi: 10.1128/AAC.02353-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30670416 Free PMC article.

135

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.

Cirulli ET, Nicoletti P, Abramson K, Andrade RJ, Bjornsson ES, Chalasani N, Fontana RJ, Hallberg P, Li YJ, Lucena MI, Long N, Molokhia M, Nelson MR, Odin JA, Pirmohamed M, Rafnar T, Serrano J, Stefánsson K, Stolz A, Daly AK, Aithal GP, Watkins PB; Drug-Induced Liver Injury Network (DILIN) investigators; International DILI consortium (iDILIC). Cirulli ET, et al. Gastroenterology. 2019 May;156(6):1707-1716.e2. doi: 10.1053/j.gastro.2019.01.034. Epub 2019 Jan 18. Gastroenterology. 2019. PMID: 30664875 Free PMC article.

136

Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles.

Nicoletti P, Aithal GP, Chamberlain TC, Coulthard S, Alshabeeb M, Grove JI, Andrade RJ, Bjornsson E, Dillon JF, Hallberg P, Lucena MI, Maitland-van der Zee AH, Martin JH, Molokhia M, Pirmohamed M, Wadelius M, Shen Y, Nelson MR, Daly AK; International Drug-Induced Liver Injury Consortium (iDILIC). Nicoletti P, et al. Clin Pharmacol Ther. 2019 Jul;106(1):245-253. doi: 10.1002/cpt.1375. Epub 2019 Mar 19. Clin Pharmacol Ther. 2019. PMID: 30661239 Free article.

137

Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers.

Alhilali KA, Al-Attar Z, Gibson A, Tailor A, Meng X, Monshouwer M, Snoeys J, Park BK, Naisbitt DJ. Alhilali KA, et al. Toxicol Sci. 2019 Apr 1;168(2):597-609. doi: 10.1093/toxsci/kfz007. Toxicol Sci. 2019. PMID: 30649540

138

Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis.

Carr DF, Wang CW, Bellón T, Ressel L, Nwikue G, Shrivastava V, Bergfeld W, Jorgensen AL, Chung WH, Pirmohamed M. Carr DF, et al. Br J Dermatol. 2019 Jul;181(1):166-174. doi: 10.1111/bjd.17610. Epub 2019 Mar 26. Br J Dermatol. 2019. PMID: 30613954 Free PMC article.

139

Characterisation of a functional rat hepatocyte spheroid model.

Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Harding AL, Mistry P, Webb SD. Kyffin JA, et al. Toxicol In Vitro. 2019 Mar;55:160-172. doi: 10.1016/j.tiv.2018.12.014. Epub 2018 Dec 20. Toxicol In Vitro. 2019. PMID: 30578835 Free PMC article.

140

Controversies in drug allergy: Testing for delayed reactions.

Phillips EJ, Bigliardi P, Bircher AJ, Broyles A, Chang YS, Chung WH, Lehloenya R, Mockenhaupt M, Peter J, Pirmohamed M, Roujeau JC, Shear NH, Tanno LK, Trubiano J, Valluzzi R, Barbaud A. Phillips EJ, et al. J Allergy Clin Immunol. 2019 Jan;143(1):66-73. doi: 10.1016/j.jaci.2018.10.030. Epub 2018 Dec 17. J Allergy Clin Immunol. 2019. PMID: 30573342 Free PMC article. Review.

141

Predicting Drug-Drug Interactions Between Rifampicin and Long-Acting Cabotegravir and Rilpivirine Using Physiologically Based Pharmacokinetic Modeling.

Rajoli RKR, Curley P, Chiong J, Back D, Flexner C, Owen A, Siccardi M. Rajoli RKR, et al. J Infect Dis. 2019 May 5;219(11):1735-1742. doi: 10.1093/infdis/jiy726. J Infect Dis. 2019. PMID: 30566691 Free PMC article.

142

Overview of the blood compatibility of nanomedicines: A trend analysis of in vitro and in vivo studies.

Urbán P, Liptrott NJ, Bremer S. Urbán P, et al. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019 May;11(3):e1546. doi: 10.1002/wnan.1546. Epub 2018 Dec 17. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2019. PMID: 30556649 Free PMC article. Review.

143

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.

Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, Ciccacci C, Carcas AJ, Borobia AM, Tong HY, Dávila-Fajardo C, Rodrigues Botton M, Bourgeois S, Deloukas P, Caldwell MD, Burmester JK, Berg RL, Cavallari LH, Drozda K, Huang M, Zhao LZ, Cen HJ, Gonzalez-Conejero R, Roldan V, Nakamura Y, Mushiroda T, Gong IY, Kim RB, Hirai K, Itoh K, Isaza C, Beltrán L, Jiménez-Varo E, Cañadas-Garre M, Giontella A, Kringen MK, Haug KBF, Gwak HS, Lee KE, Minuz P, Lee MTM, Lubitz SA, Scott S, Mazzaccara C, Sacchetti L, Genç E, Özer M, Pathare A, Krishnamoorthy R, Paldi A, Siguret V, Loriot MA, Kutala VK, Suarez-Kurtz G, Perini J, Denny JC, Ramirez AH, Mittal B, Rathore SS, Sagreiya H, Altman R, Shahin MHA, Khalifa SI, Limdi NA, Rivers C, Shendre A, Dillon C, Suriapranata IM, Zhou HH, Tan SL, Tatarunas V, Lesauskaite V, Zhang Y, Maitland-van der Zee AH, Verhoef TI, de Boer A, Taljaard M, Zambon CF, Pengo V, Zhang JE, Pirmohamed M, Johnson JA, Fava C. Danese E, et al. Clin Pharmacol Ther. 2019 Jun;105(6):1477-1491. doi: 10.1002/cpt.1323. Epub 2019 Feb 17. Clin Pharmacol Ther. 2019. PMID: 30506689 Free PMC article.

144

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture.

Kelly RA, Leedale J, Harrell A, Beard DA, Randle LE, Chadwick AE, Webb SD. Kelly RA, et al. PLoS One. 2018 Nov 29;13(11):e0207803. doi: 10.1371/journal.pone.0207803. eCollection 2018. PLoS One. 2018. PMID: 30496306 Free PMC article.

145

Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug-drug interaction?

Abdullahi ST, Olagunju A, Soyinka JO, Bolarinwa RA, Olarewaju OJ, Bakare-Odunola MT, Owen A, Khoo S. Abdullahi ST, et al. Br J Clin Pharmacol. 2019 Mar;85(3):540-550. doi: 10.1111/bcp.13821. Epub 2019 Jan 2. Br J Clin Pharmacol. 2019. PMID: 30471138 Free PMC article. Clinical Trial.

146

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.

Copple IM, den Hollander W, Callegaro G, Mutter FE, Maggs JL, Schofield AL, Rainbow L, Fang Y, Sutherland JJ, Ellis EC, Ingelman-Sundberg M, Fenwick SW, Goldring CE, van de Water B, Stevens JL, Park BK. Copple IM, et al. Arch Toxicol. 2019 Feb;93(2):385-399. doi: 10.1007/s00204-018-2354-1. Epub 2018 Nov 13. Arch Toxicol. 2019. PMID: 30426165 Free PMC article.

147

Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine.

Walimbwa SI, Lamorde M, Waitt C, Kaboggoza J, Else L, Byakika-Kibwika P, Amara A, Gini J, Winterberg M, Chiong J, Tarning J, Khoo SH. Walimbwa SI, et al. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01310-18. doi: 10.1128/AAC.01310-18. Print 2019 Feb. Antimicrob Agents Chemother. 2019. PMID: 30420479 Free PMC article.

148

The skin as a metabolic and immune-competent organ: Implications for drug-induced skin rash.

Sharma A, Saito Y, Hung SI, Naisbitt D, Uetrecht J, Bussiere J. Sharma A, et al. J Immunotoxicol. 2019 Dec;16(1):1-12. doi: 10.1080/1547691X.2018.1514444. Epub 2018 Oct 14. J Immunotoxicol. 2019. PMID: 30318948 Free article. Review.

149

Drug repurposing: progress, challenges and recommendations.

Pushpakom S, Iorio F, Eyers PA, Escott KJ, Hopper S, Wells A, Doig A, Guilliams T, Latimer J, McNamee C, Norris A, Sanseau P, Cavalla D, Pirmohamed M. Pushpakom S, et al. Nat Rev Drug Discov. 2019 Jan;18(1):41-58. doi: 10.1038/nrd.2018.168. Epub 2018 Oct 12. Nat Rev Drug Discov. 2019. PMID: 30310233 Review.

150

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity.

Leedale J, Sharkey KJ, Colley HE, Norton ÁM, Peeney D, Mason CL, Sathish JG, Murdoch C, Sharma P, Webb SD. Leedale J, et al. iScience. 2018 Jun 29;4:84-96. doi: 10.1016/j.isci.2018.05.012. Epub 2018 May 18. iScience. 2018. PMID: 30240756 Free PMC article.

151

Nonmedical prescriber experiences of training and competence to report adverse drug reactions in the UK.

Thompson A, Randall C, Howard J, Barker C, Bowden D, Mooney P, Munyika A, Smith S, Pirmohamed M. Thompson A, et al. J Clin Pharm Ther. 2019 Feb;44(1):78-83. doi: 10.1111/jcpt.12756. Epub 2018 Sep 11. J Clin Pharm Ther. 2019. PMID: 30206951 Free PMC article.

152

Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies.

Martin AP, Downing J, Cochrane M, Collins B, Francis B, Haycox A, Alfirevic A, Pirmohamed M. Martin AP, et al. Crit Rev Oncol Hematol. 2018 Oct;130:92-107. doi: 10.1016/j.critrevonc.2018.07.012. Epub 2018 Aug 3. Crit Rev Oncol Hematol. 2018. PMID: 30196916

153

HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors.

Usui T, Tailor A, Faulkner L, Meng X, Farrell J, Daly AK, Dear GJ, Park BK, Naisbitt DJ. Usui T, et al. Chem Res Toxicol. 2018 Oct 15;31(10):1022-1024. doi: 10.1021/acs.chemrestox.8b00163. Epub 2018 Sep 13. Chem Res Toxicol. 2018. PMID: 30179004

154

Critical assessment of approaches for molecular docking to elucidate associations of HLA alleles with adverse drug reactions.

Ramsbottom KA, Carr DF, Jones AR, Rigden DJ. Ramsbottom KA, et al. Mol Immunol. 2018 Sep;101:488-499. doi: 10.1016/j.molimm.2018.08.003. Epub 2018 Aug 18. Mol Immunol. 2018. PMID: 30125869 Free PMC article.

155

The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity.

Kamalian L, Douglas O, Jolly CE, Snoeys J, Simic D, Monshouwer M, Williams DP, Kevin Park B, Chadwick AE. Kamalian L, et al. Toxicol In Vitro. 2018 Dec;53:136-147. doi: 10.1016/j.tiv.2018.08.001. Epub 2018 Aug 7. Toxicol In Vitro. 2018. PMID: 30096366 Free article.

156

A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis.

Foulkes AC, Watson DS, Carr DF, Kenny JG, Slidel T, Parslew R, Pirmohamed M; PSORT Consortium; Anders S, Reynolds NJ, Griffiths CEM, Warren RB, Barnes MR. Foulkes AC, et al. J Invest Dermatol. 2019 Jan;139(1):100-107. doi: 10.1016/j.jid.2018.04.041. Epub 2018 Jul 17. J Invest Dermatol. 2019. PMID: 30030151 Free PMC article.

157

Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort.

Turner RM, Fontana V, Bayliss M, Whalley S, Santoyo Castelazo A, Pirmohamed M. Turner RM, et al. J Pharm Biomed Anal. 2018 Sep 10;159:272-281. doi: 10.1016/j.jpba.2018.06.062. Epub 2018 Jul 3. J Pharm Biomed Anal. 2018. PMID: 30005242 Free PMC article.

158

Warfarin: The End or the End of One Size Fits All Therapy?

Pirmohamed M. Pirmohamed M. J Pers Med. 2018 Jun 28;8(3):22. doi: 10.3390/jpm8030022. J Pers Med. 2018. PMID: 29958440 Free PMC article. Review.

159

New uses for old drugs.

Pantziarka P, Pirmohamed M, Mirza N. Pantziarka P, et al. BMJ. 2018 Jun 26;361:k2701. doi: 10.1136/bmj.k2701. BMJ. 2018. PMID: 29945952 No abstract available.

160

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR. Evans JP, et al. Oncotarget. 2018 Jun 5;9(43):27104-27116. doi: 10.18632/oncotarget.25497. eCollection 2018 Jun 5. Oncotarget. 2018. PMID: 29930754 Free PMC article.

161

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.

Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L, Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B, Goldring CE, Park BK, Timmer J, Klingmüller U. Oppelt A, et al. NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z. eCollection 2018. NPJ Syst Biol Appl. 2018. PMID: 29900006 Free PMC article.

162

Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development.

Olayanju A, Jones L, Greco K, Goldring CE, Ansari T. Olayanju A, et al. J Appl Toxicol. 2019 Jan;39(1):4-15. doi: 10.1002/jat.3641. Epub 2018 Jun 11. J Appl Toxicol. 2019. PMID: 29893059 Review.

163

Genetic and nongenetic factors that may predispose individuals to allergic drug reactions.

Gibson A, Ogese M, Pirmohamed M. Gibson A, et al. Curr Opin Allergy Clin Immunol. 2018 Aug;18(4):325-332. doi: 10.1097/ACI.0000000000000459. Curr Opin Allergy Clin Immunol. 2018. PMID: 29889140 Review.

164

17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use.

Farzan N, Vijverberg SJ, Hernandez-Pacheco N, Bel EHD, Berce V, Bønnelykke K, Bisgaard H, Burchard EG, Canino G, Celedón JC, Chew FT, Chiang WC, Cloutier MM, Forno E, Francis B, Hawcutt DB, Herrera-Luis E, Kabesch M, Karimi L, Melén E, Mukhopadhyay S, Merid SK, Palmer CN, Pino-Yanes M, Pirmohamed M, Potočnik U, Repnik K, Schieck M, Sevelsted A, Sio YY, Smyth RL, Soares P, Söderhäll C, Tantisira KG, Tavendale R, Tse SM, Turner S, Verhamme KM, Maitland-van der Zee AH. Farzan N, et al. Allergy. 2018 Oct;73(10):2083-2088. doi: 10.1111/all.13499. Epub 2018 Jul 9. Allergy. 2018. PMID: 29885281 Free PMC article.

165

Adrenal suppression with inhaled corticosteroids: the seed and the soil - Authors' reply.

Hawcutt DB, Francis B, Pirmohamed M. Hawcutt DB, et al. Lancet Respir Med. 2018 Jun;6(6):e20. doi: 10.1016/S2213-2600(18)30149-8. Lancet Respir Med. 2018. PMID: 29856322 No abstract available.

166

Pharmacogenetics of Adverse Drug Reactions.

Osanlou O, Pirmohamed M, Daly AK. Osanlou O, et al. Adv Pharmacol. 2018;83:155-190. doi: 10.1016/bs.apha.2018.03.002. Adv Pharmacol. 2018. PMID: 29801574 Review.

167

Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach.

Bollegala D, Maskell S, Sloane R, Hajne J, Pirmohamed M. Bollegala D, et al. JMIR Public Health Surveill. 2018 May 9;4(2):e51. doi: 10.2196/publichealth.8214. JMIR Public Health Surveill. 2018. PMID: 29743155 Free PMC article.

168

Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4⁺ T-Cells from Hypersensitive Patients.

Monroy-Arreola A, Durán-Figueroa NV, Méndez-Flores S, Domínguez-Cherit J, Watkinson J, Badillo-Corona JA, Whitaker P, Naisbitt DJ, Castrejón-Flores JL. Monroy-Arreola A, et al. Chem Res Toxicol. 2018 Jun 18;31(6):454-461. doi: 10.1021/acs.chemrestox.7b00330. Epub 2018 May 16. Chem Res Toxicol. 2018. PMID: 29644860

169

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.

Lister A, Bourgeois S, Imenez Silva PH, Rubio-Aliaga I, Marbet P, Walsh J, Shelton LM, Keller B, Verrey F, Devuyst O, Giesbertz P, Daniel H, Goldring CE, Copple IM, Wagner CA, Odermatt A. Lister A, et al. Sci Rep. 2018 Apr 4;8(1):5629. doi: 10.1038/s41598-018-24000-2. Sci Rep. 2018. PMID: 29618784 Free PMC article.

170

Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin.

McWilliam SJ, Antoine DJ, Jorgensen AL, Smyth RL, Pirmohamed M. McWilliam SJ, et al. Sci Rep. 2018 Mar 23;8(1):5094. doi: 10.1038/s41598-018-23466-4. Sci Rep. 2018. PMID: 29572451 Free PMC article.

171

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

Hawcutt DB, Francis B, Carr DF, Jorgensen AL, Yin P, Wallin N, O'Hara N, Zhang EJ, Bloch KM, Ganguli A, Thompson B, McEvoy L, Peak M, Crawford AA, Walker BR, Blair JC, Couriel J, Smyth RL, Pirmohamed M. Hawcutt DB, et al. Lancet Respir Med. 2018 Jun;6(6):442-450. doi: 10.1016/S2213-2600(18)30058-4. Epub 2018 Mar 15. Lancet Respir Med. 2018. PMID: 29551627 Free PMC article.

172

Direct oral anticoagulants versus warfarin: is new always better than the old?

Burn J, Pirmohamed M. Burn J, et al. Open Heart. 2018 Feb 7;5(1):e000712. doi: 10.1136/openhrt-2017-000712. eCollection 2018. Open Heart. 2018. PMID: 29531758 Free PMC article. Review.

173

Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response.

Bowden DL, Sutton PA, Wall MA, Jithesh PV, Jenkins RE, Palmer DH, Goldring CE, Parsons JL, Park BK, Kitteringham NR, Vimalachandran D. Bowden DL, et al. J Proteomics. 2018 May 15;179:53-60. doi: 10.1016/j.jprot.2018.02.030. Epub 2018 Mar 6. J Proteomics. 2018. PMID: 29518574

174

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.

Pushpakom SP, Adaikalakoteswari A, Owen A, Back DJ, Tripathi G, Kumar S, McTernan P, Pirmohamed M. Pushpakom SP, et al. Diab Vasc Dis Res. 2018 May;15(3):233-242. doi: 10.1177/1479164118757924. Epub 2018 Feb 21. Diab Vasc Dis Res. 2018. PMID: 29466880 Free PMC article.

175

Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions.

Sullivan A, Watkinson J, Waddington J, Park BK, Naisbitt DJ. Sullivan A, et al. Expert Opin Drug Metab Toxicol. 2018 Mar;14(3):261-274. doi: 10.1080/17425255.2018.1441285. Epub 2018 Feb 22. Expert Opin Drug Metab Toxicol. 2018. PMID: 29460640 Review.

176

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity.

Usui T, Faulkner L, Farrell J, French NS, Alfirevic A, Pirmohamed M, Park BK, Naisbitt DJ. Usui T, et al. Chem Res Toxicol. 2018 Mar 19;31(3):165-167. doi: 10.1021/acs.chemrestox.8b00030. Epub 2018 Feb 14. Chem Res Toxicol. 2018. PMID: 29436218

177

Correction: Definition of the Nature and Hapten Threshold of the β-Lactam Antigen Required for T Cell Activation In Vitro and in Patients.

Meng X, Al-Attar Z, Yaseen FS, Jenkins R, Earnshaw C, Whitaker P, Peckham D, French NS, Naisbitt DJ, Park BK. Meng X, et al. J Immunol. 2018 Mar 1;200(5):1952. doi: 10.4049/jimmunol.1800020. Epub 2018 Feb 2. J Immunol. 2018. PMID: 29427419 Free article. No abstract available.

178

Correction: The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.

Gibson A, Faulkner L, Lichtenfels M, Ogese M, Al-Attar Z, Alfirevic A, Esser PR, Martin SF, Pirmohamed M, Park BK, Naisbitt DJ. Gibson A, et al. J Immunol. 2018 Mar 1;200(5):1951. doi: 10.4049/jimmunol.1800019. Epub 2018 Feb 2. J Immunol. 2018. PMID: 29427416 Free article. No abstract available.

179

Impact of cell types and culture methods on the functionality of in vitro liver systems - A review of cell systems for hepatotoxicity assessment.

Kyffin JA, Sharma P, Leedale J, Colley HE, Murdoch C, Mistry P, Webb SD. Kyffin JA, et al. Toxicol In Vitro. 2018 Apr;48:262-275. doi: 10.1016/j.tiv.2018.01.023. Epub 2018 Feb 1. Toxicol In Vitro. 2018. PMID: 29408671 Free article. Review.

180

Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.

Phillips EJ, Sukasem C, Whirl-Carrillo M, Müller DJ, Dunnenberger HM, Chantratita W, Goldspiel B, Chen YT, Carleton BC, George AL Jr, Mushiroda T, Klein T, Gammal RS, Pirmohamed M. Phillips EJ, et al. Clin Pharmacol Ther. 2018 Apr;103(4):574-581. doi: 10.1002/cpt.1004. Epub 2018 Feb 2. Clin Pharmacol Ther. 2018. PMID: 29392710 Free PMC article.

181

Nucleic acid based therapies: developing frontier for precision medicine.

Pirmohamed M. Pirmohamed M. BMJ. 2018 Jan 23;360:k223. doi: 10.1136/bmj.k223. BMJ. 2018. PMID: 29363539 No abstract available.

182

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.

Pridgeon CS, Schlott C, Wong MW, Heringa MB, Heckel T, Leedale J, Launay L, Gryshkova V, Przyborski S, Bearon RN, Wilkinson EL, Ansari T, Greenman J, Hendriks DFG, Gibbs S, Sidaway J, Sison-Young RL, Walker P, Cross MJ, Park BK, Goldring CEP. Pridgeon CS, et al. Arch Toxicol. 2018 Feb;92(2):557-569. doi: 10.1007/s00204-018-2152-9. Epub 2018 Jan 23. Arch Toxicol. 2018. PMID: 29362863 Free PMC article. Review.

183

The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy.

Sivapalarajah S, Krishnakumar M, Bickerstaffe H, Chan Y, Clarkson J, Hampden-Martin A, Mirza A, Tanti M, Marson A, Pirmohamed M, Mirza N. Sivapalarajah S, et al. Epilepsia. 2018 Feb;59(2):492-501. doi: 10.1111/epi.13994. Epub 2018 Jan 17. Epilepsia. 2018. PMID: 29341109

184

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.

Bell CC, Dankers ACA, Lauschke VM, Sison-Young R, Jenkins R, Rowe C, Goldring CE, Park K, Regan SL, Walker T, Schofield C, Baze A, Foster AJ, Williams DP, van de Ven AWM, Jacobs F, Houdt JV, Lähteenmäki T, Snoeys J, Juhila S, Richert L, Ingelman-Sundberg M. Bell CC, et al. Toxicol Sci. 2018 Apr 1;162(2):655-666. doi: 10.1093/toxsci/kfx289. Toxicol Sci. 2018. PMID: 29329425 Free PMC article.

185

SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.

White KD, Abe R, Ardern-Jones M, Beachkofsky T, Bouchard C, Carleton B, Chodosh J, Cibotti R, Davis R, Denny JC, Dodiuk-Gad RP, Ergen EN, Goldman JL, Holmes JH 4th, Hung SI, Lacouture ME, Lehloenya RJ, Mallal S, Manolio TA, Micheletti RG, Mitchell CM, Mockenhaupt M, Ostrov DA, Pavlos R, Pirmohamed M, Pope E, Redwood A, Rosenbach M, Rosenblum MD, Roujeau JC, Saavedra AP, Saeed HN, Struewing JP, Sueki H, Sukasem C, Sung C, Trubiano JA, Weintraub J, Wheatley LM, Williams KB, Worley B, Chung WH, Shear NH, Phillips EJ. White KD, et al. J Allergy Clin Immunol Pract. 2018 Jan-Feb;6(1):38-69. doi: 10.1016/j.jaip.2017.11.023. J Allergy Clin Immunol Pract. 2018. PMID: 29310768 Free PMC article. Review.

186

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.

McCormack M, Gui H, Ingason A, Speed D, Wright GEB, Zhang EJ, Secolin R, Yasuda C, Kwok M, Wolking S, Becker F, Rau S, Avbersek A, Heggeli K, Leu C, Depondt C, Sills GJ, Marson AG, Auce P, Brodie MJ, Francis B, Johnson MR, Koeleman BPC, Striano P, Coppola A, Zara F, Kunz WS, Sander JW, Lerche H, Klein KM, Weckhuysen S, Krenn M, Gudmundsson LJ, Stefánsson K, Krause R, Shear N, Ross CJD, Delanty N; EPIGEN Consortium;; Pirmohamed M, Carleton BC; Canadian Pharmacogenomics Network for Drug Safety;; Cendes F, Lopes-Cendes I, Liao WP, O'Brien TJ, Sisodiya SM; EpiPGX Consortium;; Cherny S, Kwan P, Baum L; International League Against Epilepsy Consortium on Complex Epilepsies;; Cavalleri GL. McCormack M, et al. Neurology. 2018 Jan 23;90(4):e332-e341. doi: 10.1212/WNL.0000000000004853. Epub 2017 Dec 29. Neurology. 2018. PMID: 29288229 Free PMC article.

187

Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis.

Whitfield JB, Masson S, Liangpunsakul S, Hyman J, Mueller S, Aithal G, Eyer F, Gleeson D, Thompson A, Stickel F, Soyka M, Daly AK, Cordell HJ, Liang T, Foroud T, Lumeng L, Pirmohamed M, Nalpas B, Bence C, Jacquet JM, Louvet A, Moirand R, Nahon P, Naveau S, Perney P, Podevin P, Haber PS, Seitz HK, Day CP, Mathurin P, Morgan TM, Seth D; GenomALC Consortium. Whitfield JB, et al. Alcohol. 2018 Feb;66:1-7. doi: 10.1016/j.alcohol.2017.07.006. Epub 2017 Sep 23. Alcohol. 2018. PMID: 29277282 Free PMC article.

188

Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans.

Knetsch CW, Kumar N, Forster SC, Connor TR, Browne HP, Harmanus C, Sanders IM, Harris SR, Turner L, Morris T, Perry M, Miyajima F, Roberts P, Pirmohamed M, Songer JG, Weese JS, Indra A, Corver J, Rupnik M, Wren BW, Riley TV, Kuijper EJ, Lawley TD. Knetsch CW, et al. J Clin Microbiol. 2018 Feb 22;56(3):e01384-17. doi: 10.1128/JCM.01384-17. Print 2018 Mar. J Clin Microbiol. 2018. PMID: 29237792 Free PMC article.

189

MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury.

Howell LS, Ireland L, Park BK, Goldring CE. Howell LS, et al. Expert Rev Mol Diagn. 2018 Jan;18(1):47-54. doi: 10.1080/14737159.2018.1415145. Epub 2017 Dec 15. Expert Rev Mol Diagn. 2018. PMID: 29235390 Review.

190

Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue-engineered skin equivalents.

Smith SA, Colley HE, Sharma P, Slowik KM, Sison-Young R, Sneddon A, Webb SD, Murdoch C. Smith SA, et al. Exp Dermatol. 2018 May;27(5):473-475. doi: 10.1111/exd.13483. Epub 2018 Jan 5. Exp Dermatol. 2018. PMID: 29227563 Free article.

191

The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.

Cliff J, Jorgensen AL, Lord R, Azam F, Cossar L, Carr DF, Pirmohamed M. Cliff J, et al. Crit Rev Oncol Hematol. 2017 Dec;120:127-140. doi: 10.1016/j.critrevonc.2017.09.009. Epub 2017 Sep 25. Crit Rev Oncol Hematol. 2017. PMID: 29198326

192

Exome sequencing of synchronously resected primary colorectal tumours and colorectal liver metastases to inform oncosurgical management.

Sutton PA, Jithesh PV, Jones RP, Evans JP, Vimalachandran D, Malik HZ, Park BK, Goldring CE, Palmer DH, Kitteringham NR. Sutton PA, et al. Eur J Surg Oncol. 2018 Jan;44(1):115-121. doi: 10.1016/j.ejso.2017.10.211. Epub 2017 Nov 13. Eur J Surg Oncol. 2018. PMID: 29174709

193

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.

Forootan SS, Mutter FE, Kipar A, Iwawaki T, Francis B, Goldring CE, Park BK, Copple IM. Forootan SS, et al. Sci Rep. 2017 Nov 22;7(1):16084. doi: 10.1038/s41598-017-16491-2. Sci Rep. 2017. PMID: 29167567 Free PMC article.

194

Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts.

Amali MO, Jenkins RE, Meng X, Faulkner L, Whitaker P, Peckham D, Park BK, Naisbitt DJ. Amali MO, et al. Chem Res Toxicol. 2017 Dec 18;30(12):2097-2099. doi: 10.1021/acs.chemrestox.7b00291. Epub 2017 Nov 22. Chem Res Toxicol. 2017. PMID: 29148816

195

Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.

Dear JW, Clarke JI, Francis B, Allen L, Wraight J, Shen J, Dargan PI, Wood D, Cooper J, Thomas SHL, Jorgensen AL, Pirmohamed M, Park BK, Antoine DJ. Dear JW, et al. Lancet Gastroenterol Hepatol. 2018 Feb;3(2):104-113. doi: 10.1016/S2468-1253(17)30266-2. Epub 2017 Nov 14. Lancet Gastroenterol Hepatol. 2018. PMID: 29146439 Free PMC article.

196

Repurposing Statins for Renal Protection: Is It a Class Effect?

McWilliam SJ, Antoine DJ, Pirmohamed M. McWilliam SJ, et al. Clin Transl Sci. 2018 Mar;11(2):100-102. doi: 10.1111/cts.12521. Epub 2017 Nov 15. Clin Transl Sci. 2018. PMID: 29139191 Free PMC article. No abstract available.

197

Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.

Manolio TA, Hutter CM, Avigan M, Cibotti R, Davis RL, Denny JC, Grenade L, Wheatley LM, Carrington MN, Chantratita W, Chung WH, Dalton AD, Hung SI, Lee MTM, Leeder JS, Lertora JJL, Mahasirimongkol S, McLeod HL, Mockenhaupt M, Pacanowski M, Phillips EJ, Pinheiro S, Pirmohamed M, Sung C, Suwankesawong W, Trepanier L, Tumminia SJ, Veenstra D, Yuliwulandari R, Shear NH. Manolio TA, et al. Clin Pharmacol Ther. 2018 Mar;103(3):390-394. doi: 10.1002/cpt.890. Epub 2017 Nov 6. Clin Pharmacol Ther. 2018. PMID: 29105735 Free PMC article. Review.

198

An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review.

Martin A, Downing J, Maden M, Fleeman N, Alfirevic A, Haycox A, Pirmohamed M. Martin A, et al. Pharmacogenomics. 2017 Nov;18(16):1541-1550. doi: 10.2217/pgs-2017-0076. Epub 2017 Nov 2. Pharmacogenomics. 2017. PMID: 29095091 Free PMC article.

199

A common missense variant of LILRB5 is associated with statin intolerance and myalgia.

K Siddiqui M, Maroteau C, Veluchamy A, Tornio A, Tavendale R, Carr F, Abelega NU, Carr D, Bloch K, Hallberg P, Yue QY, Pearson ER, Colhoun HM, Morris AD, Dow E, George J, Pirmohamed M, Ridker PM, Doney ASF, Alfirevic A, Wadelius M, Maitland-van der Zee AH, Chasman DI, Palmer CNA; PREDICTION-ADR Consortium. K Siddiqui M, et al. Eur Heart J. 2017 Dec 21;38(48):3569-3575. doi: 10.1093/eurheartj/ehx467. Eur Heart J. 2017. PMID: 29020356 Free PMC article. Clinical Trial.

200

Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout.

Plumpton CO, Alfirevic A, Pirmohamed M, Hughes DA. Plumpton CO, et al. Rheumatology (Oxford). 2017 Oct 1;56(10):1729-1739. doi: 10.1093/rheumatology/kex253. Rheumatology (Oxford). 2017. PMID: 28957559

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