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1991 1
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2003 8
2004 13
2005 12
2006 27
2007 34
2008 69
2009 83
2010 92
2011 101
2012 89
2013 102
2014 100
2015 145
2016 169
2017 168
2018 151
2019 175
2020 206
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Page 1
Inhibition of CDK8 rescues impaired ischemic fracture healing.
Capobianco CA, Song MJ, Farrell EC, Knights AJ, Kessell K, Donneys A, Schmanski JT, Schroeder LR, Chen M, Roninson IB, Wagley Y, Maerz T, Hankenson KD. Capobianco CA, et al. NPJ Regen Med. 2026 Jan 17;11(1):12. doi: 10.1038/s41536-026-00456-z. NPJ Regen Med. 2026. PMID: 41547960 Free PMC article.
Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer.
Mbah NE, Sutton D, Hong HS, Singhal R, Menjivar RE, Giza H, Sajjakulnukit P, Perricone M, Nwosu ZC, Alektiar J, Lin J, Long D, Andren AC, Zhang L, Crawford HC, Frankel TL, Pasca di Magliano M, Franchi L, Shah YM, Lyssiotis CA. Mbah NE, et al. bioRxiv [Preprint]. 2026 Jan 11:2026.01.09.698662. doi: 10.64898/2026.01.09.698662. bioRxiv. 2026. Update in: Cancer Metab. 2026 Apr 4;14(1):9. doi: 10.1186/s40170-026-00428-3. PMID: 41542512 Free PMC article. Updated. Preprint.
Dynamic release of extracellular particles after opening of the blood-brain barrier predicts glioblastoma susceptibility to paclitaxel.
Youngblood MW, Kumari A, Kang YT, Gould A, Habashy K, Gomez M, Lingamarla H, Morey T, Chen L, Congivaram H, Ward R, Zhang H, Sears TK, McCortney K, Pituch KC, Torres Ponce EM, Zarrieneh A, Nieves M, Vandermolen S, Primdahl D, Dixit K, Lukas RV, Kumthekar P, Dmello C, Bouchoux G, Canney M, Amidei C, Stupp R, Nagrath S, Sonabend AM. Youngblood MW, et al. Nat Commun. 2025 Dec 16;16(1):11045. doi: 10.1038/s41467-025-65681-4. Nat Commun. 2025. PMID: 41402297 Free PMC article. Clinical Trial.
CDK9 is a dependency in GATA-3 driven and MCL-1 independent T-cell Lymphomas.
Wang C, Abdelrahman S, Geng X, Burgess A, Hu YS, Rauf MA, Kady N, Fu Y, Reilly TA, Maine IP, Boonstra P, Sabitov K, Murga-Zamalloa C, Wilcox RA. Wang C, et al. Blood Cancer J. 2025 Nov 27;16(1):9. doi: 10.1038/s41408-025-01427-1. Blood Cancer J. 2025. PMID: 41309546 Free PMC article.
Reprogramming the Immune Suppressive Tumor Microenvironment in Glioma Enhances the Efficacy of Immune-Mediated Gene Therapy.
McClellan BL, Peña Agudelo JA, Mujeeb AA, Dabaja AA, Zhu Z, Raghuram S, Varela ML, Tronrud C, Banerjee K, Wei A, Calatroni C, Zhang LH, Romero LC, Oh P, Alghamri MS, Robbins A, Perricone MD, Wang Y, Shay B, Sajjakulnukit P, Lyssiotis CA, Welch JD, Schwendeman A, Lowenstein PR, Castro MG. McClellan BL, et al. bioRxiv [Preprint]. 2025 Nov 13:2025.11.11.687828. doi: 10.1101/2025.11.11.687828. bioRxiv. 2025. Update in: Mol Ther Oncol. 2026 Apr 21;34(2):201215. doi: 10.1016/j.omton.2026.201215. PMID: 41293016 Free PMC article. Updated. Preprint.
Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via endocytosis of E-cadherin.
Lim YX, Liu M, Garb BF, Furgal A, Li S, Choi J, Liu Q, Kopera H, Hilgarth R, de Medeiros MC, Gonzalez-Maldonado L, Lanigan T, McHugh J, Wolf G, Mierzwa ML, Baladandayuthapani V, Rozek LS, Sartor MA, D'Silva NJ. Lim YX, et al. bioRxiv [Preprint]. 2025 Oct 16:2025.10.16.682706. doi: 10.1101/2025.10.16.682706. bioRxiv. 2025. PMID: 41278700 Free PMC article. Preprint.
Does Basal Cell Carcinoma Arise from a Precursor Lesion?
Wong SY, Harms PW, Dlugosz AA. Wong SY, et al. J Invest Dermatol. 2026 Apr;146(4):905-913. doi: 10.1016/j.jid.2025.09.381. Epub 2025 Nov 15. J Invest Dermatol. 2026. PMID: 41240053 Free PMC article. Review.
The hematopoietic stem cell MYB enhancer is essential for and recurrently amplified during T cell leukemogenesis.
Mullin C, Lin K, Choe E, Sha C, Shukla Z, Campbell K, McCarter AC, Wang A, Nieves-Salva J, Khan S, Keeley TM, Liang S, Wang Q, Melnick AF, Evans P, Monovich AC, Iyer A, Kodgule R, Deng Y, da Veiga Leprevost F, Barnett KR, Pölönen P, Khoriaty R, Savic D, Teachey DT, Mullighan CG, Cieslik M, Nesvizhskii AI, Samuelson LC, Jones M, Li Q, Ryan RJ, Chiang MY. Mullin C, et al. J Clin Invest. 2025 Oct 23;136(1):e187998. doi: 10.1172/JCI187998. eCollection 2026 Jan 2. J Clin Invest. 2025. PMID: 41129262 Free PMC article.
Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation.
Lasse Opsahl EL, Espinoza CE, Olivei AC, Okoye JO, Watkoske H, Hoffman MT, Avritt FR, Elhossiny AM, Bischoff AC, Donahue KL, Poggi M, Kadiyala P, Arya N, Shi J, Lee KE, Zhang Y, Carpenter ES, Szczepanski JM, Frankel TL, Pasca di Magliano M. Lasse Opsahl EL, et al. Cancer Res. 2026 Jan 2;86(1):22-39. doi: 10.1158/0008-5472.CAN-25-3472. Cancer Res. 2026. PMID: 41105672 Free PMC article.
A PP2A molecular glue overcomes RAS/MAPK inhibitor resistance in KRAS-mutant non-small cell lung cancer.
Raines B, Tseng-Rogenski S, Dowdican AC, Peris I, Hinderman M, Zawacki KP, Barrie K, Hodges Onishi G, Dymond AM, Luther TK, Musser S, Karaj Majchrowski B, Brenner JC, Ahmed A, Taylor DJ, O'Connor CM, Narla G. Raines B, et al. J Clin Invest. 2025 Oct 14;135(23):e193790. doi: 10.1172/JCI193790. eCollection 2025 Dec 1. J Clin Invest. 2025. PMID: 41086023 Free PMC article.
GliFHV mice: a tool to investigate GLI processing and localization.
Dear HS, Franks NE, Markley EE, Holtz AM, Song JY, Johnson CN, Medina-Cabrera PI, Hernandez D, Joel P, Pasca di Magliano M, Wellik DM, Allen BL. Dear HS, et al. Development. 2025 Nov 1;152(21):dev204251. doi: 10.1242/dev.204251. Epub 2025 Nov 7. Development. 2025. PMID: 41058551 Free PMC article.
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer.
Luo J, Chen Z, Qiao Y, Tien JC, Young E, Mannan R, Mahapatra S, Bhattacharyya R, Xiao L, He T, Eyunni S, Zhang Y, Zheng Y, Su F, Cao X, Wang R, Cheng Y, Seri R, George J, Shahine M, Miner SJ, Rees MG, Ronan MM, Roth JA, Vaishampayan U, Wang M, Wang S, Parolia A, Chinnaiyan AM. Luo J, et al. Nat Genet. 2025 Oct;57(10):2468-2481. doi: 10.1038/s41588-025-02336-6. Epub 2025 Oct 3. Nat Genet. 2025. PMID: 41044247 Free PMC article.
Molecular Profiling of Primary versus Paired Asynchronous Metastatic Clear Cell Renal Cell Carcinoma Reveals Heterogeneity in Tumor Immune Microenvironment.
Cotta B, Nallandhighal S, Monda S, Knuth Z, Triner D, Zhang Y, Wang R, Kasputis A, Cao X, Udager A, Dhanasekaran SM, Palapattu GS, Mehra R, Cieslik MP, Morgan TM, Salami SS. Cotta B, et al. Res Sq [Preprint]. 2025 Sep 25:rs.3.rs-7087297. doi: 10.21203/rs.3.rs-7087297/v1. Res Sq. 2025. Update in: Sci Rep. 2026 Jan 28;16(1):5473. doi: 10.1038/s41598-026-35021-7. PMID: 41041533 Free PMC article. Updated. Preprint.
Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression.
Bischoff AC, Brown K, Lasse Opsahl EL, Watkoske HR, Espinoza CE, Okoye JO, Olivei AC, Green LM, Rai R, The S, Yan W, denDekker AD, Carpenter ES, Shi J, Bednar F, Frankel TL, Zhang Y, Pasca di Magliano M. Bischoff AC, et al. Cancer Res. 2026 Jan 16;86(2):331-348. doi: 10.1158/0008-5472.CAN-25-1014. Cancer Res. 2026. PMID: 41032745 Free PMC article.
Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation.
Tower CA, Manske G, Ferrell EL, Anbarci DN, Jorgensen K, Ma B, Aboelenain M, Ranjan R, Chakraborty S, Moritz L, Das A, Boiani M, Black BE, Chavez S, Marsh EE, Shikanov A, Schindler K, Chen X, Hammoud SS. Tower CA, et al. Dev Cell. 2026 Jan 14;61(1):146-163.e10. doi: 10.1016/j.devcel.2025.08.017. Epub 2025 Sep 24. Dev Cell. 2026. PMID: 40997799 Free PMC article.
Autophagy Upregulation in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma Uncovers a Novel Therapeutic Target.
Núñez FJ, Banerjee K, Mujeeb AA, Mauser A, Tronrud CE, Zhu Z, Raghuram S, Sheth MR, Agudelo JAP, Zelaya J, Taher A, Kadiyala P, Carney SV, Garcia-Fabiani MB, Comba A, Alghamri MS, McClellan BL, Nwosu ZC, Hong HS, Sajjakulnukit P, Qin T, Sartor MA, Ljungman M, Welch JD, Cheng SY, Lowenstein PR, Lahann J, Lyssiotis CA, Castro MG. Núñez FJ, et al. Res Sq [Preprint]. 2025 Sep 11:rs.3.rs-7483444. doi: 10.21203/rs.3.rs-7483444/v1. Res Sq. 2025. PMID: 40964044 Free PMC article. Preprint.
Immunocompetent Murine Models Recapitulate the Heterogeneous Tumor-Immune Microenvironment of Human Liposarcoma.
Shafer AM, Kenna E, Golden LF, Elhossiny AM, Perry KD, Wilkowski J, Yan W, Kaczkofsky B, McGue J, Bresler SC, Courtney AH, Dalman JM, Galbán CJ, Jiang W, Espinoza CE, Chugh R, Iyer MK, Frankel TL, Pasca di Magliano M, Dlugosz AA, Angeles CV. Shafer AM, et al. Clin Cancer Res. 2025 Dec 1;31(23):5078-5095. doi: 10.1158/1078-0432.CCR-25-1628. Clin Cancer Res. 2025. PMID: 40928975 Free PMC article.
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T-cell Polarization.
Griffith BD, Kadiyala P, McGue J, Sun L, Kumar A, Espinoza CE, Donahue KL, Iyer MK, Speyer C, Nelson S, Spiteri A, Elhossiny AM, Brown K, Attebury H, Bednar F, Carpenter ES, Kryczek I, Zhang Y, Zou W, Pasca di Magliano M, Frankel TL. Griffith BD, et al. Cancer Discov. 2026 Jan 12;16(1):114-134. doi: 10.1158/2159-8290.CD-25-0377. Cancer Discov. 2026. PMID: 40905825 Free PMC article.
Rewiring of cortical glucose metabolism fuels human brain cancer growth.
Scott AJ, Mittal A, Meghdadi B, O'Brien A, Bailleul J, Sravya P, Achreja A, Zhou W, Xu J, Lin A, Wilder-Romans K, Liang N, Kothari AU, Korimerla N, Edwards DM, Wu Z, Feng J, Su S, Zhang L, Sajjakulnukit P, Andren AC, Park JO, Ten Hoeve J, Tarnal V, Redic KA, Qi NR, Fischer JL, Yang E, Regan MS, Stopka SA, Baquer G, Suresh K, Sarkaria JN, Lawrence TS, Venneti S, Agar NYR, Vlashi E, Lyssiotis CA, Al-Holou WN, Nagrath D, Wahl DR. Scott AJ, et al. Nature. 2025 Oct;646(8084):413-422. doi: 10.1038/s41586-025-09460-7. Epub 2025 Sep 3. Nature. 2025. PMID: 40903569 Free PMC article.
Functional Proximity across an mRNA.
Hatfield BM, Weidmann CA, McCutchin CA, Irving PS, Nelson IM, Felder S, Weeks KM. Hatfield BM, et al. Biochemistry. 2025 Sep 16;64(18):3854-3865. doi: 10.1021/acs.biochem.5c00340. Epub 2025 Aug 12. Biochemistry. 2025. PMID: 40792674 Free PMC article.
Glucose Metabolism Sustains Aberrant STAT3 Signaling in Colorectal Cancer via Glycosylated Paracrine Factors.
Buscher K, Temprine K, Mays C, Aabed N, Kerk S, Bell HN, Nieto Carrion JA, Greenbaum H, Ponnusamy V, Ramakrishnan SK, Lyssiotis CA, Xue X, Shah YM. Buscher K, et al. bioRxiv [Preprint]. 2025 Jul 26:2025.07.22.666143. doi: 10.1101/2025.07.22.666143. bioRxiv. 2025. Update in: Sci Signal. 2026 Mar 03;19(927):eadz6443. doi: 10.1126/scisignal.adz6443. PMID: 40777356 Free PMC article. Updated. Preprint.
Primary and metastatic cellular landscapes in human pancreatic cancer.
Steele NG, Sirihorachai VR, Elhossiny AM, Loveless IM, Kadiyala P, Bonilla M, Lasse-Opsahl EL, Vargas CS, Donahue KL, Kemp SB, Gunchick V, Shah YM, Frankel TL, Bednar F, Rao A, Allen BL, Shi J, Sahai V, Crawford HC, Carpenter ES, Pasca di Magliano M. Steele NG, et al. iScience. 2025 Jun 26;28(8):113012. doi: 10.1016/j.isci.2025.113012. eCollection 2025 Aug 15. iScience. 2025. PMID: 40703450 Free PMC article.
SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress.
Wolin E, Guo JK, Blanco MR, Goronzy IN, Gorhe D, Dong W, Perez AA, Keskin A, Valenzuela E, Abdou AA, Urbinati CR, Kaufhold R, Rube HT, Brito Querido J, Guttman M, Jovanovic M. Wolin E, et al. Cell. 2025 Sep 18;188(19):5384-5402.e25. doi: 10.1016/j.cell.2025.06.042. Epub 2025 Jul 22. Cell. 2025. PMID: 40701149 Free PMC article.
Transcriptional profiling clarifies a program of enzalutamide extreme non-response in lethal prostate cancer.
Kumaraswamy A, Hu YM, Yates JA, Zhang C, Rodansky E, Khokhani D, Flores D, Duan Z, Zhang Y, Tabatabaei S, Slottke R, Ye S, Lara P, Foye A, Ryan CJ, Quigley DA, Huang J, Aggarwal R, Reiter RE, Wicha MS, Beer TM, Rettig M, Gleave M, Evans CP, Witte ON, Stuart JM, Thomas GV, Feng FY, Small EJ, Xia Z, Alumkal JJ. Kumaraswamy A, et al. NPJ Precis Oncol. 2025 Jul 7;9(1):223. doi: 10.1038/s41698-025-01002-8. NPJ Precis Oncol. 2025. PMID: 40624104 Free PMC article.
Tumoroid model recreates clinically relevant phenotypes of high grade serous ovarian cancer (HGSC) cells, carcinoma associated fibroblasts, and macrophages.
Burkhard KM, Semwal A, Johnson BK, Chu KC, Kranick RJ, Rayan M, DiFeo A, Shen H, Mehta G. Burkhard KM, et al. Res Sq [Preprint]. 2025 Jun 19:rs.3.rs-6614892. doi: 10.21203/rs.3.rs-6614892/v1. Res Sq. 2025. Update in: Acta Biomater. 2026 Mar;213:251-268. doi: 10.1016/j.actbio.2026.02.005. PMID: 40585272 Free PMC article. Updated. Preprint.
Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD.
Huang W, Zhang Y, Das NK, Solanki S, Jain C, El-Derany MO, Koo I, Bell HN, Aabed N, Singhal R, Castillo C, Buscher K, Ying Y, Dimitroff J, Sharma A, Shi J, Hogan SP, Dame MK, Higgins PDR, Colacino JA, Oh TG, Spence JR, Patterson AD, Greenberg AS, Greenson JK, Nusrat A, Shah YM. Huang W, et al. Nat Metab. 2025 Jul;7(7):1358-1374. doi: 10.1038/s42255-025-01313-x. Epub 2025 Jun 26. Nat Metab. 2025. PMID: 40571769
Divergent FOXA1 mutations drive prostate tumorigenesis and therapy-resistant cellular plasticity.
Eyunni S, Mannan R, Zhang Y, Young E, Zhang Q, Luo J, Pang M, Mahapatra S, Tien JC, George JM, Jaber M, Hakkani H, Carson SE, Todd AJ, Hosseini N, Gondal M, Rebernick RJ, Cao X, Su F, Wang R, Mehra R, Li J, Cieslik M, Chinnaiyan AM, Parolia A. Eyunni S, et al. Science. 2025 Sep 4;389(6764):eadv2367. doi: 10.1126/science.adv2367. Epub 2025 Sep 4. Science. 2025. PMID: 40570057 Free PMC article.
Positionally distinct interferon-stimulated dermal immune-acting fibroblasts promote neutrophil recruitment in Sweet syndrome.
Cavagnero KJ, Albright J, Li F, Liu E, Dokoshi T, Bogle R, Kirma J, Kahlenberg JM, Billi AC, Fox J, Chan MP, Coon A, Dobry CJ, Hinds B, Tsoi LC, Harms PW, Gudjonsson JE, Gallo RL. Cavagnero KJ, et al. J Allergy Clin Immunol. 2025 Oct;156(4):966-979.e8. doi: 10.1016/j.jaci.2025.05.029. Epub 2025 Jun 16. J Allergy Clin Immunol. 2025. PMID: 40516577 Free PMC article.
Sequential 90Y Selective Internal Radiation Therapy (SIRT) and Stereotactic Body Radiation Therapy (SBRT) using 90Y PET-based Absorbed Dose Maps: Interim Analysis of a Phase 1 Study.
Polan DF, Mikell JK, Fitzpatrick K, Gemmete JJ, Christensen JA, Anbari H, Roseland M, Evans JR, Chang DT, Sanogo M, Kapoor BS, Schipper MJ, Cao Y, Aryal MP, Lawrence TS, Cuneo KC, Dewaraja YK. Polan DF, et al. Adv Radiat Oncol. 2025 Feb 22;10(7):101743. doi: 10.1016/j.adro.2025.101743. eCollection 2025 Jul. Adv Radiat Oncol. 2025. PMID: 40503427 Free PMC article.
Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity.
Pan T, Lin G, Li X, VanHeyningen D, Walker JC, Kohli S, Saravanan A, Kondur A, Jaklic DC, Pantoja-Gutierrez S, Vaid S, Sturza J, Inoki K, Imamichi T, Chang W, Dang LT. Pan T, et al. bioRxiv [Preprint]. 2025 May 14:2025.05.13.653911. doi: 10.1101/2025.05.13.653911. bioRxiv. 2025. Update in: Stem Cell Reports. 2026 Apr 14;21(4):102833. doi: 10.1016/j.stemcr.2026.102833. PMID: 40462897 Free PMC article. Updated. Preprint.
PROX1 is an early driver of lineage plasticity in prostate cancer.
Duan Z, Shi M, Kumaraswamy A, Lin D, Khokhani D, Wang Y, Zhang C, Flores D, Rodansky E, Swaim OA, Storck WK, Beck HN, Patel RA, Sayar E, Hanratty BP, Xue H, Dong X, Maylin ZR, Wan R, Quigley DA, Sjöström M, Hu YM, Zhao F, Xia Z, Cheng S, Yu X, Feng FY, Zhang L, Aggarwal R, Small EJ, Ravikumar V, Rao A, Bedi K, Lee JK, Morrissey C, Coleman I, Nelson PS, Corey E, Udager AM, Rebernick RJ, Cieslik MP, Chinnaiyan AM, Yates JA, Haffner MC, Wang Y, Alumkal JJ. Duan Z, et al. J Clin Invest. 2025 Jun 2;135(11):e187490. doi: 10.1172/JCI187490. eCollection 2025 Jun 2. J Clin Invest. 2025. PMID: 40454483 Free PMC article.
An engineered viral protein activates STAT5 to prevent T cell suppression.
Zheng Y, Gu Z, Shudde CE, Piper TL, Wang X, Aleck GA, Zhou J, King D, Chanda MK, Trinch L, Zou W, Courtney AH. Zheng Y, et al. Sci Immunol. 2025 May 23;10(107):eadn9633. doi: 10.1126/sciimmunol.adn9633. Epub 2025 May 23. Sci Immunol. 2025. PMID: 40408430 Free PMC article.
Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer.
DeAngelo SL, Zhao L, Dziechciarz S, Shin M, Solanki S, Balia A, El-Derany MO, Castillo C, Qin Y, Das NK, Bell HN, Paulo JA, Zhang Y, Rossiter NJ, McCulla EC, He J, Talukder I, Ng BW, Schafer ZT, Neamati N, Mancias JD, Koutmos M, Shah YM. DeAngelo SL, et al. Cancer Res. 2025 Aug 1;85(15):2788-2804. doi: 10.1158/0008-5472.CAN-24-3478. Cancer Res. 2025. PMID: 40392234 Free PMC article.
STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity.
Zhou J, Tison K, Zhou H, Bai L, Acharyya RK, McEachern D, Metwally H, Wang Y, Pitter M, Choi JE, Vatan L, Liao P, Yu J, Lin H, Jiang L, Wei S, Gao X, Grove S, Parolia A, Cieslik M, Kryczek I, Green MD, Lin JX, Chinnaiyan AM, Leonard WJ, Wang S, Zou W. Zhou J, et al. Nature. 2025 Jul;643(8071):519-528. doi: 10.1038/s41586-025-09000-3. Epub 2025 May 14. Nature. 2025. PMID: 40369063 Free PMC article.
Nerve Types and Classification of Neurons Innervating Oral Cancer.
Perez-Pacheco CG, Gonzalez-Maldonado LA, Furgal A, Schmitd LB, Constantinescu BSC, Li Y, Gannot N, Perry SK, Rozek L, Wolf G, Emrick JJ, Li P, D'Silva NJ. Perez-Pacheco CG, et al. Clin Cancer Res. 2025 Jul 1;31(13):2741-2755. doi: 10.1158/1078-0432.CCR-24-2375. Clin Cancer Res. 2025. PMID: 40310470 Free PMC article.
Facile generation of drug-like conformational antibodies specific for amyloid fibrils.
Desai AA, Zupancic JM, Trzeciakiewicz H, Gerson JE, DuBois KN, Skinner ME, Sharkey LM, McArthur N, Ferris SP, Bhatt NN, Makowski EK, Smith MD, Chen H, Huang J, Jerez C, Kuo YH, Kane RS, Kanaan NM, Paulson HL, Tessier PM. Desai AA, et al. Nat Chem Biol. 2025 Jun;21(6):916-925. doi: 10.1038/s41589-025-01881-9. Epub 2025 Apr 29. Nat Chem Biol. 2025. PMID: 40301692 Free PMC article.
An immunocompetent mouse model of liposarcoma.
Shafer AM, Kenna E, Golden LF, Elhossiny AM, Perry KD, Wilkowski J, Yan W, Kaczkofsky B, McGue J, Bresler SC, Courtney AH, Dalman JM, Galban CJ, Jiang W, Espinoza CE, Chugh R, Iyer MK, Frankel TL, di Magliano MP, Dlugosz AA, Angeles CV. Shafer AM, et al. bioRxiv [Preprint]. 2025 Feb 4:2025.01.31.634916. doi: 10.1101/2025.01.31.634916. bioRxiv. 2025. Update in: Clin Cancer Res. 2025 Dec 1;31(23):5078-5095. doi: 10.1158/1078-0432.CCR-25-1628. PMID: 40297505 Free PMC article. Updated. Preprint.
Comparison of Human Papillomavirus Genotyping by Research vs. Clinical Assay for Two Self-Collection Devices.
Harper DM, Young AP, O'Dwyer MC, Olorunfemi M, Laurie A, Sen A, Chen D, Morrison L, Kelley SA, McEvoy A, Schneiderhan J, Rockwell P, Zazove P, Gabison J, Chargot JE, Gallagher K, Prussack J, Butcher EA, Alves ML, Haro EA, El Khoury C, Smith R, Saunders N, Campbell E, Walline HM. Harper DM, et al. Cancer Epidemiol Biomarkers Prev. 2025 Jul 1;34(7):1103-1110. doi: 10.1158/1055-9965.EPI-25-0116. Cancer Epidemiol Biomarkers Prev. 2025. PMID: 40279251 Free PMC article. Clinical Trial.
Connectivity Regression.
Desai N, Baladandayuthapani V, Shinohara RT, Morris JS. Desai N, et al. Biostatistics. 2025 Dec 31;26(1):kxaf002. doi: 10.1093/biostatistics/kxaf002. Biostatistics. 2025. PMID: 40272849 Free PMC article.
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer.
Cheng C, Hu J, Mannan R, He T, Bhattacharyya R, Magnuson B, Wisniewski JP, Peters S, Karim SA, MacLean DJ, Karabürk H, Zhang L, Rossiter NJ, Zheng Y, Xiao L, Li C, Awad D, Mahapatra S, Bao Y, Zhang Y, Cao X, Wang Z, Mehra R, Morlacchi P, Sahai V, Pasca di Magliano M, Shah YM, Weisman LS, Morton JP, Ding K, Qiao Y, Lyssiotis CA, Chinnaiyan AM. Cheng C, et al. Nature. 2025 Jun;642(8068):776-784. doi: 10.1038/s41586-025-08917-z. Epub 2025 Apr 23. Nature. 2025. PMID: 40269157 Free PMC article.
Metabolic stress and age drive inflammation and cognitive decline in mice and humans.
Elzinga SE, Guo K, Turfah A, Henn RE, Webber-Davis IF, Hayes JM, Pacut CM, Teener SJ, Carter AD, Rigan DM, Allouch AM, Jang DG, Parent R, Glass E, Murphy GG, Lentz SI, Chen KS, Zhao L, Hur J, Feldman EL. Elzinga SE, et al. Alzheimers Dement. 2025 Mar;21(3):e70060. doi: 10.1002/alz.70060. Alzheimers Dement. 2025. PMID: 40110679 Free PMC article.
LSD1+8a is an RNA biomarker of neuroendocrine prostate cancer.
Kumaraswamy A, Mannan R, Swaim OA, Rodansky E, Wang XM, Udager A, Mehra R, Li H, Morrissey C, Corey E, Haffner MC, Nelson PS, Chinnaiyan AM, Yates JA, Alumkal JJ. Kumaraswamy A, et al. Neoplasia. 2025 May;63:101151. doi: 10.1016/j.neo.2025.101151. Epub 2025 Mar 14. Neoplasia. 2025. PMID: 40088674 Free PMC article.
Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma.
Iyer AR, Gurumurthy A, Chu SA, Kodgule R, Aguilar AR, Saari T, Ramzan A, Rosa J, Gupta J, Emmanuel A, Hall CN, Runge JS, Owczarczyk AB, Cho JW, Weiss MB, Anyoha R, Sikkink K, Gemus S, Fulco CP, Perry AM, Schmitt AD, Engreitz JM, Brown NA, Cieslik MP, Ryan RJH. Iyer AR, et al. Blood Cancer Discov. 2025 May 5;6(3):233-253. doi: 10.1158/2643-3230.BCD-24-0126. Blood Cancer Discov. 2025. PMID: 40067173 Free PMC article.
A Phase 2 Study of Multiparametric Magnetic Resonance Imaging-Guided High-Dose Response-Adaptive Radiation Therapy With Concurrent Temozolomide in Patients With Newly Diagnosed Glioblastoma: Results From an Interim Analysis.
Kim MM, Aryal MP, Suresh K, Rosen BS, Parmar H, You D, Leung D, Clarke N, Fortunato J, Al-Holou W, Heth J, Altshuler D, Hollon T, Edwards DM, Wahl DR, Lawrence TS, Cao Y. Kim MM, et al. Int J Radiat Oncol Biol Phys. 2025 Jul 1;122(3):605-610. doi: 10.1016/j.ijrobp.2025.02.020. Epub 2025 Mar 8. Int J Radiat Oncol Biol Phys. 2025. PMID: 40058709 Clinical Trial.
Adaptive interventions for alcohol misuse and violent behaviors among adolescents and emerging adults in the emergency department: Outcomes from a sequential multiple assignment randomized controlled trial.
Walton MA, Seewald L, Carter PM, Ngo Q, Blow FC, Bourque C, Pearson C, Battisti KA, An L, Wank M, Zhu Y, Kidwell KM. Walton MA, et al. Drug Alcohol Depend. 2025 May 1;270:112615. doi: 10.1016/j.drugalcdep.2025.112615. Epub 2025 Feb 21. Drug Alcohol Depend. 2025. PMID: 40020642 Free PMC article. Clinical Trial.
Assessment of Environmental, Sociocultural, and Physiological Influences on Women's Toileting Decisions and Behaviors Using "Where I Go": Pilot Study of a Mobile App.
Smith AR, Mueller ER, Lewis CE, Markland A, Smerdon C, Smith AL, Sutcliffe S, Wyman JF, Low LK, Miller JM; Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium. Smith AR, et al. JMIR Mhealth Uhealth. 2025 Feb 12;13:e56533. doi: 10.2196/56533. JMIR Mhealth Uhealth. 2025. PMID: 39980161 Free PMC article.
Active DNA demethylation is upstream of rod-photoreceptor fate determination and required for retinal development.
Hernández-Núñez I, Urman A, Zhang X, Jacobs W, Hoffman C, Rebba S, Harding EG, Li Q, Mao F, Cani AK, Chen S, Dawlaty MM, Rao RC, Ruzycki PA, Edwards JR, Clark BS. Hernández-Núñez I, et al. bioRxiv [Preprint]. 2025 Feb 3:2025.02.03.636318. doi: 10.1101/2025.02.03.636318. bioRxiv. 2025. Update in: PLoS Biol. 2025 Aug 4;23(8):e3003332. doi: 10.1371/journal.pbio.3003332. PMID: 39975078 Free PMC article. Updated. Preprint.
Small circular RNAs as vaccines for cancer immunotherapy.
Zhang Y, Liu X, Shen T, Wang Q, Zhou S, Yang S, Liao S, Su T, Mei L, Zhang B, Huynh K, Xie L, Guo Y, Guo C, Tyc KM, Qu X, Wang XY, Liu J, Zhu G. Zhang Y, et al. Nat Biomed Eng. 2025 Feb;9(2):249-267. doi: 10.1038/s41551-025-01344-5. Epub 2025 Feb 7. Nat Biomed Eng. 2025. PMID: 39920212 Free PMC article.
The C2 domain augments Ras GTPase-activating protein catalytic activity.
Paul ME, Chen D, Vish KJ, Lartey NL, Hughes E, Freeman ZT, Saunders TL, Stiegler AL, King PD, Boggon TJ. Paul ME, et al. Proc Natl Acad Sci U S A. 2025 Feb 11;122(6):e2418433122. doi: 10.1073/pnas.2418433122. Epub 2025 Feb 3. Proc Natl Acad Sci U S A. 2025. PMID: 39899710 Free PMC article.
Cervical Cancer Screening in Women With Physical Disabilities.
Vinson AH, Norrid C, Haro EK, Ernst S, El Khoury C, Alves ML, Kieber-Emmons A, Kamath Mulki A, Butcher EA, Kalpakjian C, McKee MM, Harper DM. Vinson AH, et al. JAMA Netw Open. 2025 Jan 2;8(1):e2457290. doi: 10.1001/jamanetworkopen.2024.57290. JAMA Netw Open. 2025. PMID: 39878976 Free PMC article.
KRASG12D drives immunosuppression in lung adenocarcinoma through paracrine signaling.
Lasse-Opsahl EL, Barravecchia I, McLintock E, Lee JM, Ferris SF, Espinoza CE, Hinshaw R, Cavanaugh S, Robotti M, Rober L, Brown K, Abdelmalak KY, Galban CJ, Frankel TL, Zhang Y, Pasca di Magliano M, Galban S. Lasse-Opsahl EL, et al. JCI Insight. 2025 Jan 9;10(1):e182228. doi: 10.1172/jci.insight.182228. JCI Insight. 2025. PMID: 39782689 Free PMC article.
Multidimensional analyses identify genes of high priority for pancreatic cancer research.
Nwosu ZC, Giza HM, Nassif M, Charlestin V, Menjivar RE, Kim D, Kemp SB, Sajjakulnukit P, Andren A, Zhang L, Lai WK, Loveless I, Steele N, Hu J, Hu B, Wang S, Pasca di Magliano M, Lyssiotis CA. Nwosu ZC, et al. JCI Insight. 2025 Jan 7;10(4):e174264. doi: 10.1172/jci.insight.174264. JCI Insight. 2025. PMID: 39774001 Free PMC article.
Recruitment of Young Gay, Bisexual, and Other Men Who Have Sex With Men for a Web-Based Human Papillomavirus Vaccination Intervention: Differences in Participant Characteristics and Study Engagement by Recruitment Source in a Randomized Controlled Trial.
Marshall DJ, Gower AL, Katz ML, Bauermeister JA, Shoben AB, Reiter PL. Marshall DJ, et al. J Med Internet Res. 2025 Jan 3;27:e64668. doi: 10.2196/64668. J Med Internet Res. 2025. PMID: 39752644 Free PMC article. Clinical Trial.
Complement C3d enables cell-mediated immunity capable of distinguishing spontaneously transformed from nontransformed cells.
Platt JL, Zhao C, Chicca J, Pianko MJ, Han J, The S, Rao A, Keller ET, Garcia de Mattos Barbosa M, Naing L, Pasieka-Axenov T, Axenov L, Schaefer S, Farkash E, Cascalho M. Platt JL, et al. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2405824121. doi: 10.1073/pnas.2405824121. Epub 2024 Dec 18. Proc Natl Acad Sci U S A. 2024. PMID: 39693340 Free PMC article.
Olaparib and Radiotherapy Induce Type I Interferon- and CD8+ T Cell-Dependent Sensitization to Immunotherapy in Pancreatic Cancer.
Valvo VM, Zhang Q, Jiang L, Holcomb EA, Pearson AN, Edmunds AG, Faulkner HG, James JG, Tate A, Huber AK, Wang Z, Guo Y, Karnak D, Parsels LA, Parsels JD, Lei YL, Rehemtulla A, Lin H, Carpenter ES, Wahl DR, Sahai V, Lawrence TS, Green MD, Morgan MA. Valvo VM, et al. Mol Cancer Ther. 2025 Jun 4;24(6):843-858. doi: 10.1158/1535-7163.MCT-24-0210. Mol Cancer Ther. 2025. PMID: 39688341 Free PMC article.
Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors.
Huang G, Stevens R, Hucek DG, Purohit T, Li S, Miao H, Trost E, Hewett G, Clegg B, Park SR, Rajanayake K, Wen B, Sun D, Cierpicki T, Grembecka J. Huang G, et al. J Med Chem. 2025 Jan 9;68(1):174-195. doi: 10.1021/acs.jmedchem.4c01673. Epub 2024 Dec 16. J Med Chem. 2025. PMID: 39680643 Free PMC article.
Human Pancreatic Cancer Single-Cell Atlas Reveals Association of CXCL10+ Fibroblasts and Basal Subtype Tumor Cells.
Loveless IM, Kemp SB, Hartway KM, Mitchell JT, Wu Y, Zwernik SD, Salas-Escabillas DJ, Brender S, George M, Makinwa Y, Stockdale T, Gartrelle K, Reddy RG, Long DW, Wombwell A, Clark JM, Levin AM, Kwon D, Huang L, Francescone R, Vendramini-Costa DB, Stanger BZ, Alessio A, Waters AM, Cui Y, Fertig EJ, Kagohara LT, Theisen B, Crawford HC, Steele NG. Loveless IM, et al. Clin Cancer Res. 2025 Feb 17;31(4):756-772. doi: 10.1158/1078-0432.CCR-24-2183. Clin Cancer Res. 2025. PMID: 39636224 Free PMC article.
Discovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα).
Rej RK, Hu B, Chen Z, Acharyya RK, Wu D, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Nishimura LS, Gersch CL, Wang M, Wen B, Sun D, Carlson K, Katzenellenbogen JA, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Rae JM, Wang S. Rej RK, et al. J Med Chem. 2024 Dec 12;67(23):20933-20965. doi: 10.1021/acs.jmedchem.4c01401. Epub 2024 Nov 25. J Med Chem. 2024. PMID: 39585895 Free PMC article.
Controlled Delivery of Paclitaxel via Stable Synthetic Protein Nanoparticles.
Mauser A, Waibel I, Banerjee K, Mujeeb AA, Gan J, Lee S, Brown W, Lang N, Gregory J, Raymond J, Franzeb M, Schwendeman A, Castro MG, Lahann J. Mauser A, et al. Adv Ther (Weinh). 2024 Nov;7(11):2400208. doi: 10.1002/adtp.202400208. Epub 2024 Jun 27. Adv Ther (Weinh). 2024. PMID: 39575154 Free PMC article.
Studies of Structure-Activity Relationship of 2-(Pyrrolidin-1ylmethyl)-1H-pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation.
Yuan X, Rech JC, Ramaraju A, Patil AD, Rajanayake K, Yuan H, Kazemi Sabzvar M, Mandal M, Cho EB, Wen B, Jiang J, Leo MD, Singh UP, Sun D, Yang CY. Yuan X, et al. ACS Med Chem Lett. 2024 Oct 18;15(11):2053-2059. doi: 10.1021/acsmedchemlett.4c00459. eCollection 2024 Nov 14. ACS Med Chem Lett. 2024. PMID: 39563831 Free PMC article.
Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial.
Mowery YM, Ballman KV, Hong AM, Schuetze SM, Wagner AJ, Monga V, Heise RS, Attia S, Choy E, Burgess MA, Bae S, Pryor DI, Van Tine BA, Tinoco G, Chmielowski B, Freeman C, Gronchi A, Meyer CF, Dickson MA, Hartner L, Davis LE, Powers BC, Moding EJ, Weinhold KJ, van de Rijn M, Brigman BE, Riedel RF, Kirsch DG. Mowery YM, et al. Lancet. 2024 Nov 23;404(10467):2053-2064. doi: 10.1016/S0140-6736(24)01812-9. Epub 2024 Nov 12. Lancet. 2024. PMID: 39547252 Free PMC article. Clinical Trial.
Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer.
Haanen TJ 3rd, Boock S, Callahan CG, Peris I, Zawacki KP, Raines B, Nino CA, Tran B, Harold A, Hodges Onishi G, Hinderman M, Dowdican A, Huang W, Taylor DJ, Taylor SE, Jackson MW, DiFeo A, O'Connor CM, Narla G. Haanen TJ 3rd, et al. Cancer Res. 2025 Feb 1;85(3):442-461. doi: 10.1158/0008-5472.CAN-24-1263. Cancer Res. 2025. PMID: 39531506 Free PMC article.
Retrospective Comparison of Targeted Anticancer Drugs Predicted by the CNS-TAP Tool Versus Those Selected by a Molecularly Driven Tumor Board in Children With DIPG.
Roberts HJ, Ravi K, Marini BL, Schepers A, Kline C, Kilburn L, Prados M, Byron SA, Sturza J, Mueller S, Koschmann C, Franson AT. Roberts HJ, et al. J Pediatr Hematol Oncol. 2025 Jan 1;47(1):19-30. doi: 10.1097/MPH.0000000000002964. Epub 2024 Nov 6. J Pediatr Hematol Oncol. 2025. PMID: 39527919 Free PMC article.
Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance.
Lin H, Tison K, Du Y, Kirchhoff P, Kim C, Wang W, Yang H, Pitter M, Yu J, Liao P, Zhou J, Vatan L, Grove S, Wei S, Vigil T, Shah YM, Mortensen R, Kryczek I, Garmire L, Sivaccumar JP, Ramesh AK, Zhang N, An Z, Wang S, Zou W. Lin H, et al. Cancer Cell. 2024 Dec 9;42(12):2032-2044.e6. doi: 10.1016/j.ccell.2024.10.010. Epub 2024 Nov 7. Cancer Cell. 2024. PMID: 39515327 Free PMC article.
Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, Wang M, Tošović J, Yang CY, Chinnaswamy K, Meagher JL, Stuckey JA, Liu C, Wang M, Wen B, Sun D, Wang S. Xu R, et al. J Med Chem. 2024 Nov 28;67(22):20495-20513. doi: 10.1021/acs.jmedchem.4c01946. Epub 2024 Nov 7. J Med Chem. 2024. PMID: 39509603 Free PMC article.
LMAN1 serves as a cargo receptor for thrombopoietin.
Everett LA, Lin Z, Friedman A, Tang VT, Myers G, Balbin-Cuesta G, King R, Zhu G, McGee B, Khoriaty R. Everett LA, et al. JCI Insight. 2024 Dec 20;9(24):e175704. doi: 10.1172/jci.insight.175704. JCI Insight. 2024. PMID: 39499573 Free PMC article.
Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer.
Acharyya RK, Rej RK, Hu B, Chen Z, Wu D, Lu J, Metwally H, McEachern D, Wang Y, Jiang W, Bai L, Tošović J, Gersch CL, Xu G, Zhang W, Wu W, Priestley ES, Sui Z, Sarkari F, Wen B, Sun D, Rae JM, Wang S. Acharyya RK, et al. J Med Chem. 2024 Nov 14;67(21):19010-19037. doi: 10.1021/acs.jmedchem.4c01521. Epub 2024 Nov 1. J Med Chem. 2024. PMID: 39485242 Free PMC article.
Immunological and molecular features of the tumor microenvironment of long-term survivors of ovarian cancer.
Nelson BH, Hamilton P, Phung MT, Milne K, Harris B, Thornton S, Stevens D, Kalaria S, Singh K, Laumont CM, Moss E, Alimujiang A, Meagher NS, Bolithon A, Fereday S, Kennedy CJ, Hendley J, Ariyaratne D, Alsop K, Traficante N, Goode EL, Karnezis A, Shen H, Richardson J, McKinnonDeurloo C, Chase A, Grout B, Doherty JA, Harris HR, Cushing-Haugen KL, Anglesio M, Heinze K, Huntsman D, Talhouk A, Hanley GE, Alsop J, Jimenez-Linan M, Pharoah PD, Boros J, Brand AH, Harnett PR, Sharma R, Hecht JL, Sasamoto N, Terry KL, Karlan B, Lester J, Carney ME, Goodman MT, Hernandez BY, Wilkens LR, Behrens S, Turzanski Fortner R, Fasching PA, Bisinotto C, Candido Dos Reis FJ, Ghatage P, Köbel M, Elishaev E, Modugno F, Cook L, Le N, Gentry-Maharaj A, Menon U, García MJ, Rodriguez-Antona C, Farrington K, Kelemen LE, Kommoss S, Staebler A, Garsed DW, Brenton JD, Piskorz AM, Bowtell DD, DeFazio A, Ramus SJ, Pike MC, Pearce CL. Nelson BH, et al. J Clin Invest. 2024 Oct 29;134(24):e179501. doi: 10.1172/JCI179501. J Clin Invest. 2024. PMID: 39470729 Free PMC article.
Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma.
Mbah NE, Myers AL, Sajjakulnukit P, Chung C, Thompson JK, Hong HS, Giza H, Dang D, Nwosu ZC, Shan M, Sweha SR, Maydan DD, Chen B, Zhang L, Magnuson B, Zhu Z, Radyk M, Lavoie B, Yadav VN, Koo I, Patterson AD, Wahl DR, Franchi L, Agnihotri S, Koschmann CJ, Venneti S, Lyssiotis CA. Mbah NE, et al. Nat Commun. 2024 Oct 17;15(1):8983. doi: 10.1038/s41467-024-52973-4. Nat Commun. 2024. PMID: 39419964 Free PMC article.
Second-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E (eIF4E) Activity in Drug-Resistant Melanoma.
Cárdenas EL, O'Rourke RL, Menon A, Vega-Hernández G, Meagher J, Stuckey J, Garner AL. Cárdenas EL, et al. bioRxiv [Preprint]. 2024 Sep 27:2024.09.25.614990. doi: 10.1101/2024.09.25.614990. bioRxiv. 2024. Update in: ACS Med Chem Lett. 2024 Dec 12;16(1):96-100. doi: 10.1021/acsmedchemlett.4c00466. PMID: 39386734 Free PMC article. Updated. Preprint.
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