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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 4
1948 3
1949 3
1950 3
1951 11
1952 9
1953 6
1954 12
1955 7
1956 5
1957 14
1958 15
1959 17
1960 19
1961 19
1962 23
1963 46
1964 62
1965 70
1966 180
1967 217
1968 219
1969 209
1970 212
1971 196
1972 211
1973 236
1974 303
1975 383
1976 429
1977 620
1978 999
1979 1216
1980 15707
1981 33549
1982 34576
1983 35045
1984 36753
1985 37478
1986 38665
1987 40091
1988 41229
1989 42822
1990 44956
1991 46225
1992 46800
1993 47553
1994 49143
1995 49518
1996 49733
1997 50046
1998 51078
1999 52565
2000 55189
2001 56528
2002 59635
2003 63870
2004 71630
2005 78231
2006 86944
2007 93442
2008 103661
2009 110463
2010 119920
2011 129044
2012 133798
2013 138846
2014 140330
2015 141507
2016 136897
2017 132405
2018 135015
2019 137002
2020 149765
2021 157194
2022 144765
2023 146045
2024 142211
2025 136070
2026 50789
2027 2

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3,551,646 results

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Page 1
Stigma, Depression, and Social Support in Black Individuals Diagnosed with Schizophrenia.
Anakwenze O, Himmelstein M, Plourde J. Anakwenze O, et al. J Racial Ethn Health Disparities. 2026 Jul 14. doi: 10.1007/s40615-026-02870-x. Online ahead of print. J Racial Ethn Health Disparities. 2026. PMID: 42446865
Depressive symptoms mediated the relationship between stigma and behavioral health outcomes, specifically psychological wellbeing and mental health recovery. Social support was shown to mitigate this relationship. Findings were consistent with prior research …
Depressive symptoms mediated the relationship between stigma and behavioral health outcomes, specifically psychological wellbeing and …
Short form scale of parent self-efficacy for general and specialized care for children with special health care needs.
Foster C, Barrera L, Kaat A, Cella D, Blackwell C, Davis M, Coller R, Heffernan M. Foster C, et al. J Patient Rep Outcomes. 2026 Jul 14. doi: 10.1186/s41687-026-01143-9. Online ahead of print. J Patient Rep Outcomes. 2026. PMID: 42446815
BACKGROUND: Self-efficacy in managing healthcare tasks has been shown to predict health behaviors and outcomes. Previous research has established the content validity of a full-length 30-item survey scale to assess the level of parents' self-efficacy when managing their ch …
BACKGROUND: Self-efficacy in managing healthcare tasks has been shown to predict health behaviors and outcomes. Previous research has …
EPR characterization of a metal-binding site in RquA.
Stowell RK, Neupane T, Mankiller KC, Manning TL, Boercker LN, DiGaetano CV, Gotshall LR, Burke MN, Ozarowski A, Ross EE, Langelaan DN, Shepherd JN, Stoll S. Stowell RK, et al. J Biol Inorg Chem. 2026 Jul 14. doi: 10.1007/s00775-026-02160-1. Online ahead of print. J Biol Inorg Chem. 2026. PMID: 42446741
Integrated 3D-QSAR and cellular profiling of sulfated and hydrophobic aminoglycoside glycans to modulate heparanase activity.
Wang J, Philip L, Vithanage TB, Gulewicz A, Abdulsalam H, Nguyen HM. Wang J, et al. Med Chem Res. 2026 Apr;35(4):834-846. doi: 10.1007/s00044-026-03553-2. Epub 2026 Apr 25. Med Chem Res. 2026. PMID: 42446733
Guided by these insights, we evaluated the lead compound L17 in HPSE-dependent cancer cell lines and observed concentration-dependent inhibition of proliferation, suppression of invasion, and reduction of extracellular HPSE levels. ...
Guided by these insights, we evaluated the lead compound L17 in HPSE-dependent cancer cell lines and observed concentration-dependent …
Advances in the development of N-acylbenzo[d][1,2,3]diazaborinin-1(2H)-ols as antibacterial agents by synthesis, characterization, and antimicrobial assay.
Woods CA, Gutierrez B, Aguinaldo N, Kanukwa P, Li Y, Hubbard B, Avila JD, Jones A, Sebok F, Groziak MP, Nalaoh P, Jenkins DM, Carbajal MB, Chow HT, Xu HH. Woods CA, et al. Med Chem Res. 2026 Apr;35(4):847-862. doi: 10.1007/s00044-026-03550-5. Epub 2026 Apr 11. Med Chem Res. 2026. PMID: 42446727
Antibiotic resistant strains of a multitude of infectious diseases have appeared, imposing a huge burden from diseases once believed to have been reduced to minor health issues. Building on prior work, twenty-one new N-acyl-1-hydroxy-2,3,1-benzodiazaborinines were synthesi …
Antibiotic resistant strains of a multitude of infectious diseases have appeared, imposing a huge burden from diseases once believed to have …
Design, Synthesis and Antitumor Activity Evaluation in Vitro of Novel 1,6-Naphthyridine Derivatives.
Si XJ, Ma XY, Zhang SL, Zheng MY, Asgari M, Feng CG. Si XJ, et al. Med Chem Res. 2026 Jun;35(6):1186-1200. doi: 10.1007/s00044-026-03576-9. Epub 2026 May 28. Med Chem Res. 2026. PMID: 42446688
In the search for novel, highly effective antitumor agents, a series of novel 1,6-naphthyridine derivatives were designed, synthesized and evaluated for antiproliferative activity against five human cancer cell lines (HepG-2, MCF-7, NCI-H1650, U87MG and A549) …
In the search for novel, highly effective antitumor agents, a series of novel 1,6-naphthyridine derivatives were designed, synthesized and e …
Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers.
Lanade O, He Z, Zhou Y, Blackman E, Gibbs D, Harrison S, Devarajan K, Andrake M, Dunbrack RL Jr, Nkogbu G, Wagh A, Slifker M, Erkmen C, Patterson F, Satti A, Lawson-Myers HD, Roberts R, Mitchell D, Liu JC, Erblich J, Ragin C. Lanade O, et al. Arch Toxicol. 2026 Jul 14. doi: 10.1007/s00204-026-04505-w. Online ahead of print. Arch Toxicol. 2026. PMID: 42446667
Tobacco use remains the leading preventable cause of cancer mortality worldwide, with marked disparities in cancer incidence and outcomes across racial and ethnic groups. ...These findings highlight the biological basis for tobacco-related cancer disparities …
Tobacco use remains the leading preventable cause of cancer mortality worldwide, with marked disparities in cancer incidence a …
Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs.
Lawson KA, Mahler SV. Lawson KA, et al. Psychopharmacology (Berl). 2026 Jul 14. doi: 10.1007/s00213-026-07125-5. Online ahead of print. Psychopharmacology (Berl). 2026. PMID: 42446628
Potentially, USVs might therefore be useful for interrogating the subjective states of rats, and thus help bridge human and rodent neuroscience....
Potentially, USVs might therefore be useful for interrogating the subjective states of rats, and thus help bridge human and rodent ne …
Design and biological evaluation of a histidine-bearing cyclometalated Pd(II) complex derived from 2-phenylpyridine.
Abedanzadeh S. Abedanzadeh S. Biometals. 2026 Jul 14. doi: 10.1007/s10534-026-00849-z. Online ahead of print. Biometals. 2026. PMID: 42446607
In vitro cytotoxic activity was evaluated against HEP G2 human hepatoma and MCF7 human breast cancer cells revealing high selectivity of complex toward HEP G2 compared to MCF7 cancer cells. The effect of complex on NIH-3T3 mouse embryonic fibrob …
In vitro cytotoxic activity was evaluated against HEP G2 human hepatoma and MCF7 human breast cancer cells revealing hi …
Goals and strategies for the indexing of publication types and study designs.
Smalheiser NR, Menke JD, Holt AW, Kilicoglu H, Schneider J. Smalheiser NR, et al. Database (Oxford). 2026 Jan 15;2026:baag039. doi: 10.1093/database/baag039. Database (Oxford). 2026. PMID: 42446388
To meet the needs of end users, particularly groups involved in evidence syntheses, PT indexing needs to be comprehensive and employ probabilistic goodness-of-fit prediction scores. Whereas existing National Library of Medicine (NLM) hierarchies place publication types and …
To meet the needs of end users, particularly groups involved in evidence syntheses, PT indexing needs to be comprehensive and employ probabi …
Applying flow cytometry-based isolation of platelet-derived microparticles to banked human plasma for cellular studies.
Fattahi N, Tyagi T, Kirlin F, Flores AL, Hwa J, Iwakiri Y, McConnell MJ. Fattahi N, et al. J Pathol. 2026 Jul 14. doi: 10.1002/path.70097. Online ahead of print. J Pathol. 2026. PMID: 42446223
Most methods use fresh platelets treated with an agonist to generate PMPs, which has restricted the size and feasibility of human studies. With the rise of large biobanks, such as the UK Biobank (https://www.ukbiobank.ac.uk/), and because microparticles are retained in cry …
Most methods use fresh platelets treated with an agonist to generate PMPs, which has restricted the size and feasibility of human stu …
Cisproplatin: A Redox-Activatable Cisplatin-Probenecid Pt(IV) Conjugate with Broad NCI-60 Potency that Decouples Antitumor Efficacy from Dose-Limiting Toxicity and Suppresses CIPN.
Kajol, Choudhury A, Banerjee A, Shukla P, Panda SJ, Pathak RK. Kajol, et al. J Med Chem. 2026 Jul 14. doi: 10.1021/acs.jmedchem.6c00253. Online ahead of print. J Med Chem. 2026. PMID: 42446174
CPP displays superior potency across the NCI-60 panel, exceeding that of cisplatin. Time-resolved speciation and other physicochemical studies validate a dual mechanism, in which its Pt(IV) state interacts with DNA noncovalently, then releases cisplatin-like Pt(II) species …
CPP displays superior potency across the NCI-60 panel, exceeding that of cisplatin. Time-resolved speciation and other physicochemica …
Brain Structural Abnormalities in Addiction Disorders: Transdiagnostic Meta-Analyses.
Banaja DM, Torres Hernandez E, Franklin CG, Fox PM, Okafor CN, Ginsburg BC, Salinas FS, Moring JC, Fox PT. Banaja DM, et al. Hum Brain Mapp. 2026 Jul;47(10):e70551. doi: 10.1002/hbm.70551. Hum Brain Mapp. 2026. PMID: 42446143
SUDs are well established in taxonomies of mental-health disorders. BAs are only recently recognized as mental-health disorders, with limited and conflicting categorizations. ...
SUDs are well established in taxonomies of mental-health disorders. BAs are only recently recognized as mental-health disorder …
Untreated obstructive sleep apnea and accelerated cognitive decline over 10 years.
Kaufmann CN, Albrecht JS, Sekhon VK, Gross AL, Wickwire EM, Amjad H, Roth DL, Malhotra A, Blinka MD, Chen X, Tseng CY, Kaizi-Lutu M, Liu C, Jiang K, Chang G, Spira AP. Kaufmann CN, et al. Alzheimers Dement. 2026 Jul;22(7):e71533. doi: 10.1002/alz.71533. Alzheimers Dement. 2026. PMID: 42445979
METHODS: We analyzed 777 participants from the 2011 National Health and Aging Trends Study (NHATS) with linked Medicare claims, with one or more claims for OSA and no baseline cognitive impairment. ...
METHODS: We analyzed 777 participants from the 2011 National Health and Aging Trends Study (NHATS) with linked Medicare claims …
A qualitative study to explore perceptions of exercise as a smoking cessation tool among people with HIV who smoke cigarettes.
SantaBarbara NJ, Louis JS, Comulada WS, Cantrell J, Finlayson HA, Wurcel AG, Erlandson KM. SantaBarbara NJ, et al. Tob Prev Cessat. 2026 Jul 10;12. doi: 10.18332/tpc/221807. eCollection 2026. Tob Prev Cessat. 2026. PMID: 42445614 Free PMC article.
METHODS: Within this qualitative study, PWH were recruited from HIV clinics in Colorado and New England between September 2025 and February 2026, and were eligible if they were aged 21 years and current smokers. Guided by the Health Belief Model (HBM) and the Social …
METHODS: Within this qualitative study, PWH were recruited from HIV clinics in Colorado and New England between September 2025 and February …
The effect of personality on likelihood of contracting SARS-CoV-2 in the United States.
Wood JK, Weston SJ, Condon DM, Kalish H, Klumpp-Thomas C, Baus HA, Wang J, Mehalko J, Travers J, Pauly K, Croker JA, Li Y, Czajkowski L, Chairez C, Snead K, Han A, Giurgea LT, Rosas LA, Bean R, Athota R, Cervantes-Medina A, Caldararo R, Kolberg MM, Kelly A, Simon R, Shafiq S, Reed S, Ford EW, Michael SG, Kimberly RP, Reis SE, Esposito D, Memoli MJ. Wood JK, et al. Pers Individ Dif. 2026 Mar;251:113549. doi: 10.1016/j.paid.2025.113549. Epub 2025 Nov 19. Pers Individ Dif. 2026. PMID: 42445597 Free PMC article.
CNTN-1 regulates malignant biological behaviors of lung squamous cell carcinoma (LUSC) via the endoplasmic reticulum stress (ERS)/epithelial-mesenchymal transition (EMT) axis.
Zhou K, Dong W, Li S, Jiang D, Wu Q, Wang Z, Li M, Zhang R. Zhou K, et al. Transl Cancer Res. 2026 Jun 30;15(6):503. doi: 10.21037/tcr-2026-0697. Epub 2026 Jun 25. Transl Cancer Res. 2026. PMID: 42445425 Free PMC article.
This study aimed to investigate the effects of Contactin-1 (CNTN-1) on the malignant biological behaviors of tumor cells and its underlying molecular mechanisms in LUSC. METHODS: A CNTN-1-knockdown NCI-H520 LUSC cell line was established. Transcriptome sequencing was perfo …
This study aimed to investigate the effects of Contactin-1 (CNTN-1) on the malignant biological behaviors of tumor cells and its underlying …
Efficacy and Safety of Modified Sishen Decoction for Tyrosine Kinase Inhibitor-Induced Diarrhea in Hepatocellular Carcinoma: A Randomized Controlled Trial.
Cao J, He S, Yu S, Shen J, Hu N, Yu D, Cao T, Jiang L, Peng J, Zhai X. Cao J, et al. J Hepatocell Carcinoma. 2026 Jul 9;13:608479. doi: 10.2147/JHC.S608479. eCollection 2026. J Hepatocell Carcinoma. 2026. PMID: 42445309 Free PMC article.
The primary outcome was the change in diarrhea grade (NCI CTCAE v4.0) from baseline to day 8. Secondary outcomes included changes in TCM-related symptom scores and safety. ...
The primary outcome was the change in diarrhea grade (NCI CTCAE v4.0) from baseline to day 8. Secondary outcomes included changes in …
Transmembrane mucin 21 drives lung adenocarcinoma growth by suppressing retinoic acid receptor β signaling.
Lv W, Huang X, Cheng X, Wang Y, Wu L, Zhu Y. Lv W, et al. J Thorac Dis. 2026 Jun 30;18(6):657. doi: 10.21037/jtd-2026-0614. Epub 2026 Jun 26. J Thorac Dis. 2026. PMID: 42444941 Free PMC article.
BACKGROUND: Lung cancer remains the most prevalent and lethal malignancy worldwide, with non-small cell lung cancer accounting for >85% of cases and lung adenocarcinoma (LUAD) representing a predominant histological subtype. ...METHODS: Mucin (MUC)21 expression w …
BACKGROUND: Lung cancer remains the most prevalent and lethal malignancy worldwide, with non-small cell lung cancer accounting …
Real world comparative outcomes of adjuvant carboplatin versus cisplatin-based chemotherapy in stage IB-IIIA non-small cell lung cancer: a propensity-weighted analysis.
Tokaz M, Heiden BT, Eaton DB Jr, Jalal S, Seyoum N, Brandt WS, Rossetti NE, Chang SH, Yan Y, Puri V, Schoen MW, Thomas TS. Tokaz M, et al. J Thorac Dis. 2026 Jun 30;18(6):663. doi: 10.21037/jtd-2026-0658. Epub 2026 Jun 26. J Thorac Dis. 2026. PMID: 42444877 Free PMC article.
BACKGROUND: Platinum-doublet adjuvant chemotherapy is standard of care for resected non-small cell lung cancer (NSCLC). Cisplatin has been historically favored for modest survival benefits, though its substantial toxicity often limits treatment completion in routine practi …
BACKGROUND: Platinum-doublet adjuvant chemotherapy is standard of care for resected non-small cell lung cancer (NSCLC). Cisplatin has …
An association between epicardial adipose tissue and prognosis in acute myocardial infarction: a systematic review and meta-analysis.
Wang J, Deng N, Huang Y, Liu Z, Zeng H. Wang J, et al. J Thorac Dis. 2026 Jun 30;18(6):583. doi: 10.21037/jtd-2026-1164. Epub 2026 Jun 26. J Thorac Dis. 2026. PMID: 42444858 Free PMC article.
Studies reporting quantitative EAT assessment [e.g., EAT thickness, volume, or density measured by echocardiography, computed tomography (CT), or cardiac magnetic resonance (CMR)] and outcomes in AMI patients were included. Risk of bias was assessed using the National I …
Studies reporting quantitative EAT assessment [e.g., EAT thickness, volume, or density measured by echocardiography, computed tomography (CT …
APOE ε4 and Alzheimer's disease biomarkers in an American Indian community.
Matheson MJ, Labounek R, Block AD, Strong C Jr, Robertson AJ, Hansen A, Kremer M, Petersen AJ, Hill A, Asken BM, Nestrasil I, Lenglet C, Li D, Henderson JN, Mantyh WG; Alzheimer's Disease Neuroimaging Initiative. Matheson MJ, et al. Alzheimers Dement (Amst). 2026 Jul 13;18(3):e70421. doi: 10.1002/dad2.70421. eCollection 2026 Jul-Sep. Alzheimers Dement (Amst). 2026. PMID: 42444729 Free PMC article.
Limitations of this study include survival bias and race-associated differences in social determinants of health that can influence the observed results....
Limitations of this study include survival bias and race-associated differences in social determinants of health that can infl …
Associations among mild behavioral impairment, cognition, and brain pathology in preclinical autosomal dominant Alzheimer's disease.
Tristão-Pereira C, Vasquez D, Alcina J, Baena A, Aguillon D, Ospina Lopera P, Londono N, Ramos C, Martinez L, Alvarez S, Vidal M, Gonzalez I, Malotaux V, He B, Giudicessi A, Ramirez-Gomez L, Gatchel J, Ismail Z, Quiroz YT. Tristão-Pereira C, et al. Alzheimers Dement (Amst). 2026 Jul 13;18(3):e70424. doi: 10.1002/dad2.70424. eCollection 2026 Jul-Sep. Alzheimers Dement (Amst). 2026. PMID: 42444728 Free PMC article.
Human RPL7 and DDX21 function synergistically with HTLV-1 Gag to overcome genomic RNA structural barriers that block tRNAPro primer annealing.
Syu YC, Long Z, Musier-Forsyth K. Syu YC, et al. Nucleic Acids Res. 2026 Jul 3;54(13):gkag680. doi: 10.1093/nar/gkag680. Nucleic Acids Res. 2026. PMID: 42444604
Human T-cell leukemia virus type 1 (HTLV-1), an oncogenic retrovirus, uses human tRNAPro to prime reverse transcription. How tRNAPro is annealed to the primer-binding site (PBS), which is embedded in a stable hairpin structure in the genomic RNA, remains unclear. In …
Human T-cell leukemia virus type 1 (HTLV-1), an oncogenic retrovirus, uses human tRNAPro to prime reverse transcription. How t …
Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala.
Magnard R, Gonzalez-Padilla D, Yalcinbas EA, Chaloux-Pinette E, Eagles NJ, Totty MS, Janak PH, Collado-Torres L, Maynard KR. Magnard R, et al. Addict Biol. 2026 Jul;31(7):e70179. doi: 10.1111/adb.70179. Addict Biol. 2026. PMID: 42444546
Together, we define how fentanyl intake alters transcriptional programs in the rat habenula and amygdala, and we link these changes to specific human cell types and risk genes for neuropsychiatric disorders and addiction....
Together, we define how fentanyl intake alters transcriptional programs in the rat habenula and amygdala, and we link these changes to speci …
Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model.
Petrisko TJ, Chu SH, Gomez-Arboledas A, Zhang B, Tenner AJ. Petrisko TJ, et al. Glia. 2026 Sep;74(9):e70189. doi: 10.1002/glia.70189. Glia. 2026. PMID: 42444329
While classical pathway activation is involved in synaptic pruning during nervous system development, it also contributes to inflammation and cognitive decline in Alzheimer's disease (AD). Constitutive genetic C1q deficiency has been shown to reduce glial activation and at …
While classical pathway activation is involved in synaptic pruning during nervous system development, it also contributes to inflammation an …
Mitigating Financial Barriers to Trauma Care in Cameroon Through Locally Designed Quality Improvement.
Zheng DJ, Tchekep M, Boumsong JB, Tsiagadigui JG, Kibu OD, Dissak-Delon FN, Oke R, Juillard C, Chichom-Mefire A, Christie SA. Zheng DJ, et al. World J Surg. 2026 Jul 14. doi: 10.1002/wjs.70495. Online ahead of print. World J Surg. 2026. PMID: 42444284
We evaluated whether the introduction of a locally designed care kit that provided essential supplies to emergency department (ED) providers without upfront payment improved timeliness and perceived affordability of initial trauma care. ...
We evaluated whether the introduction of a locally designed care kit that provided essential supplies to emergency department (ED) pr …
Prospective Validation of the Movement Disorder Society Prodromal Multiple System Atrophy Criteria in Pure Autonomic Failure.
Millar Vernetti P, Palma JA, Biaggioni I, Shibao CA, Freeman R, Gibbons C, Singer W, Coon EA, Miglis MG, Krismer F, Fanciulli A, Goldstein DS, Betensky RA, Kaufmann H. Millar Vernetti P, et al. Mov Disord. 2026 Jul 13. doi: 10.1002/mds.70417. Online ahead of print. Mov Disord. 2026. PMID: 42444112
A stricter olfactory threshold improves diagnostic performance and may enhance cohort enrichment for clinical trials. 2026 International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in …
A stricter olfactory threshold improves diagnostic performance and may enhance cohort enrichment for clinical trials. 2026 International P …
Development of the ROOTS Intervention: A Culturally Relevant Parenting Program for Promoting the Emotional and Physical Health of Young Children.
Cooper DK, Lupini F, Saini S, Wippold G, Alonzo JK, Ponder DM, Prinz RJ. Cooper DK, et al. J Community Psychol. 2026 Jul;54(5):e70128. doi: 10.1002/jcop.70128. J Community Psychol. 2026. PMID: 42444096
A needs assessment identified determinants of child health to guide the Logic Model of Child Health (Step 1), and change objectives were defined in the Logic Model of Change (Step 2). ...This study demonstrates how IM can be applied to create culturally responsive, …
A needs assessment identified determinants of child health to guide the Logic Model of Child Health (Step 1), and change objec …
Gestational Age as a Risk Factor for Neurodevelopmental Disabilities: Exploring Causal Pathways.
Cortese M, Moster D, Lie RT, Wilcox AJ. Cortese M, et al. Paediatr Perinat Epidemiol. 2026 Jul 13. doi: 10.1111/ppe.70177. Online ahead of print. Paediatr Perinat Epidemiol. 2026. PMID: 42444088
METHODS: Using data from Norway's Medical Birth Registry and other national health registries for 2.9 million births in 1967-2019, we conducted a prospective cohort analysis assessing gestational-age-specific relative risks for cerebral palsy (CP), intellectual impa …
METHODS: Using data from Norway's Medical Birth Registry and other national health registries for 2.9 million births in 1967-2 …
A prospective co-twin control analysis of internalizing and externalizing pathways for alcohol, nicotine, and cannabis use problems from adolescence through adulthood.
Foster KT, Roche DJO, Iacono WG, McGue M, Hicks BM. Foster KT, et al. Psychol Med. 2026 Jul 14;56:e227. doi: 10.1017/S0033291726104802. Psychol Med. 2026. PMID: 42444064
Whether INT operates as a cause or a shared liability with SUP (e.g. shared genetic and environmental risk) over and above an alternative cause (e.g. externalizing problems, EXT) remains unclear. ...Instead, their associations were due to common genetic and shared e …
Whether INT operates as a cause or a shared liability with SUP (e.g. shared genetic and environmental risk) over and above an alterna …
Participation in Professional American-Style Football and Suicide Mortality: 1979-2019.
Grashow R, Konstantinides N, Anderson BC, Leung M, Fung EN, Baggish AL, Daneshvar DH, Grove W, Zafonte R, Weisskopf MG. Grashow R, et al. J Neurotrauma. 2026 Aug;43(15-16):1250-1258. doi: 10.1177/08977151251408496. Epub 2026 Jan 12. J Neurotrauma. 2026. PMID: 42444048
We compared the risk of suicide among National Football League (NFL) players to Major League Baseball (MLB) and National Basketball Association (NBA) players. Death data from 1979 to 2019 were obtained from the National Death Index for 20,765 NFL, 9,684 MLB, …
We compared the risk of suicide among National Football League (NFL) players to Major League Baseball (MLB) and National Baske …
ACCELERATE-BASSO: early experiences and emerging best practices for ontology development in behavioral and social science research.
Yu Y, Kang L, Michie S, Duncan WD, Beverley J, Li F, McNeil DW, Huo N, Li H, Horridge M, Musen MA, Bian J, Tao C. Yu Y, et al. J Biomed Semantics. 2026 Jul 14. doi: 10.1186/s13326-026-00363-8. Online ahead of print. J Biomed Semantics. 2026. PMID: 42444005
BACKGROUND: Behavioral and social science research (BSSR) is essential for understanding human behavior and informing interventions, policy, and health outcomes; however, such research faces persistent challenges related to fragmented knowledge, imprecise and …
BACKGROUND: Behavioral and social science research (BSSR) is essential for understanding human behavior and informing interven …
Evaluation of a serum protein signature as monitoring biomarker for Duchenne muscular dystrophy in a long-term clinical trial with corticosteroids.
Degan C, Tobin RA, de Vries SI, Jiménez-Requena A, Peco A, Guglieri M, Diaz-Manera J, van der Burgt YEM, van Vlijmen BJM; FOR-DMD investigators of the Muscle Study Group; Hathout Y, Szigyarto CA, Dang UJ, Tsonaka R, Spitali P. Degan C, et al. Skelet Muscle. 2026 Jul 13. doi: 10.1186/s13395-026-00437-2. Online ahead of print. Skelet Muscle. 2026. PMID: 42443978
Evidence standards for multi-ancestry polygenic prediction.
Oselu B, Isewon I, Oyelade J, Iyegbe CO. Oselu B, et al. Genome Biol. 2026 Jul 13. doi: 10.1186/s13059-026-04187-8. Online ahead of print. Genome Biol. 2026. PMID: 42443945 Review.
Polygenic scores (PGS) are prospective tools for health screening, prevention and trials, but most are trained in European genome-wide association studies and lose accuracy and calibration in non-European populations and those of mixed ancestral heritage. ...
Polygenic scores (PGS) are prospective tools for health screening, prevention and trials, but most are trained in European genome-wid …
State-level restorative justice policies and mental health disparities among girl dating violence survivors in the US: A lagged cross-sectional study.
Sharpless L, Austin A, Willie TC, Kershaw T, Moracco B, Reyes L. Sharpless L, et al. BMC Public Health. 2026 Jul 13. doi: 10.1186/s12889-026-28413-x. Online ahead of print. BMC Public Health. 2026. PMID: 42443828 Free article.
Restorative justice (RJ), a policy-based, survivor-centered approach to harm repair and accountability, may be a structural intervention to promote mental health among ADV girl survivors. However, little is known about whether and how state-level RJ policies are associated …
Restorative justice (RJ), a policy-based, survivor-centered approach to harm repair and accountability, may be a structural intervention to …
Morphological Stability of Intracranial Aneurysms and the Contour Neurovascular System: A Longitudinal Analysis.
Spitz LI, Korte J, Gaidzik F, Larsen N, Behme D, Preim B, Saalfeld S. Spitz LI, et al. Cardiovasc Eng Technol. 2026 Jul 13. doi: 10.1007/s13239-026-00847-9. Online ahead of print. Cardiovasc Eng Technol. 2026. PMID: 42443660
RESULTS: Significant postprocedural changes were observed in the ostium's ellipticity index (EI; delta = -0.07 0.06, p = 0.01, d = -1.18) and neck circularity index (NCI; delta = +0.04 0.04, p = 0.04, d = 0.90). No statistically significant long-term changes were detecte …
RESULTS: Significant postprocedural changes were observed in the ostium's ellipticity index (EI; delta = -0.07 0.06, p = 0.01, d = -1.18) a …
Early life nicotine vapor exposure increases nicotine vapor seeking in adult male rats.
Maynez-Anchondo L, Rohrer O, Urbina M, Aguilar Armenta J, Gonzalez-Gutierrez T, O'Dell LE, Mendez IA. Maynez-Anchondo L, et al. Psychopharmacology (Berl). 2026 Jul 14. doi: 10.1007/s00213-026-07122-8. Online ahead of print. Psychopharmacology (Berl). 2026. PMID: 42443622
RATIONALE: The ongoing epidemic of nicotine vaping use in adolescents and young adults presents a significant health concern, yet the long-term effects of nicotine vaping remain largely unknown. OBJECTIVE: The present study aimed to investigate how nicotine vapor intake ea …
RATIONALE: The ongoing epidemic of nicotine vaping use in adolescents and young adults presents a significant health concern, yet the …
Genetic architecture of lung cancer revealed by common and rare variant analyses across population-scale biobanks.
Zhao J, Qiao L, Zhang Y, Hong H, Fan Q, Christiani DC, Chen F, Zhao Y, Shen S. Zhao J, et al. NPJ Precis Oncol. 2026 Jul 13. doi: 10.1038/s41698-026-01558-z. Online ahead of print. NPJ Precis Oncol. 2026. PMID: 42443585 Free article.
Genome-wide association studies have predominantly implicated common variants in lung cancer susceptibility, whereas the contribution of rare non-coding variation remains incompletely defined. ...CLEC12A-AS1 ranked highest; multi-omics association and chain mediation analy …
Genome-wide association studies have predominantly implicated common variants in lung cancer susceptibility, whereas the contribution …
Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders.
Shi M, Gunawan T, Malone SG, Setzer M, Piserchia Z, Davis CN, Rentsch CT, Friligkou E, Zhou H, Polimanti R, Wang L, Vaitinadin NS, Kranzler HR, Gray JC. Shi M, et al. Neuropsychopharmacology. 2026 Jul 13. doi: 10.1038/s41386-026-02494-z. Online ahead of print. Neuropsychopharmacology. 2026. PMID: 42443535 Free article.
Thus, we investigated the shared genetic architecture and neurobiological pathways between PAU and ANX using a multimethod genomic approach. ...These findings support shared genetic and neurobiological mechanisms linking PAU and ANX, while acknowledging that some si …
Thus, we investigated the shared genetic architecture and neurobiological pathways between PAU and ANX using a multimethod genomic ap …
Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions.
Nagpal S, Gibson G. Nagpal S, et al. Nat Genet. 2026 Jul 13. doi: 10.1038/s41588-026-02674-z. Online ahead of print. Nat Genet. 2026. PMID: 42443528
Differences in disease prevalence across groups, potentially including social strata, influence the relationship between PGS and risk. Here we quantified the magnitude of PGS-by-context (PGS C) interactions for seven human diseases and pairs of 75 contexts in the UK …
Differences in disease prevalence across groups, potentially including social strata, influence the relationship between PGS and risk …
A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species.
Wang D, Ming H, Yang D, Cui X, Freeman Z, Tsai LK, Wei Z, Liu L, Scatolin GN, Bennett B, Wang X, Yau K, Tao L, Tong X, Wang S, Shi KX, Evseenko D, Van Handel B, Guo L, Dai X, Xiong Y, Zhang B, Wang Y, Iyyappan R, Ojeda-Rojas OA, Hu G, McGinnis L, Paulson R, Mckim D, Kong X, Xia X, Zhang J, Chen YE, Jiang Z, Xu J, Ying QL. Wang D, et al. Cell Res. 2026 Jul 13. doi: 10.1038/s41422-026-01276-y. Online ahead of print. Cell Res. 2026. PMID: 42443522
Importantly, we demonstrated that 6iL robustly establishes and maintains human pluripotent stem cells in a naive-like state. These findings reveal conserved principles underlying ESC self-renewal across divergent mammalian species and provide a universal platform for cross …
Importantly, we demonstrated that 6iL robustly establishes and maintains human pluripotent stem cells in a naive-like state. These fi …
High-resolution reconstruction of cell-type-specific transcriptional regulatory processes from bulk sequencing samples.
Yao L, Shah SR, Ozer A, Zhu Y, Pan X, Xia T, Zhang J, Leung AK, Wei M, Lis JT, Yu H. Yao L, et al. Nat Biotechnol. 2026 Jul 13. doi: 10.1038/s41587-026-03218-w. Online ahead of print. Nat Biotechnol. 2026. PMID: 42443492
Using DeepDETAILS, we generated a compendium of high-resolution nascent transcription and histone modification signals across 39 diverse human tissues and 86 distinct cell types. Furthermore, we applied our compendium to fine-map risk variants associated with primary scler …
Using DeepDETAILS, we generated a compendium of high-resolution nascent transcription and histone modification signals across 39 diverse …
Physicochemical properties and DFT insight into choline chloride-levulinic acid deep eutectic solvent and its binary mixtures with carboxylic acids.
Jojo A, Kabane B, Hitesh, Singh P, Deenadayalu N. Jojo A, et al. Sci Rep. 2026 Jul 13. doi: 10.1038/s41598-026-61636-x. Online ahead of print. Sci Rep. 2026. PMID: 42443373 Free article.
To further elucidate the intermolecular interactions, density functional theory (DFT) calculations complemented by non-covalent interaction (NCI) and reduced density gradient (RDG) analyses were performed on deep eutectic solvent (DES) and DES-carboxylic acid systems. ...
To further elucidate the intermolecular interactions, density functional theory (DFT) calculations complemented by non-covalent interaction …
The oral microbiome is associated with stress, adversity, and mental health in young adults.
Gancz NN, Savoca PW, Callaghan BL. Gancz NN, et al. Sci Rep. 2026 Jul 13. doi: 10.1038/s41598-026-60803-4. Online ahead of print. Sci Rep. 2026. PMID: 42443351 Free article.
Acute stress responsivity and early-life adversity are both associated with oral microbiome differences that lead to increased mental and physical health risk. However, the joint association of stress responsivity and early adversity with the oral microbiome is not yet und …
Acute stress responsivity and early-life adversity are both associated with oral microbiome differences that lead to increased mental and ph …
Fragmentation-Induced Coverage Biases in Cell-Free DNA Sequencing Affect the Clinical Sensitivity of Liquid Biopsies.
Vijayan Selvarajan A, Kabiraj D, De S. Vijayan Selvarajan A, et al. Commun Biol. 2026 Jul 13. doi: 10.1038/s42003-026-10414-6. Online ahead of print. Commun Biol. 2026. PMID: 42443324 Free article.
Extensive fragmentation and degradation of cfDNA can result in uneven coverage and potential loss of genetic information. Yet, its implications for the sensitivity of non-invasive detection of clinically relevant variants remain unclear. We analyzed clinical genomic data c …
Extensive fragmentation and degradation of cfDNA can result in uneven coverage and potential loss of genetic information. Yet, its im …
Restriction spectrum imaging reveals brain microstructural correlates of obesity risk in early childhood.
Bayat M, Braun B, Curzon M, Hernandez ML, Curtis M, Coccia C, Garic D, Watts R, Irfanoglu MO, Graziano PA, Dick AS. Bayat M, et al. Sci Rep. 2026 Jul 13. doi: 10.1038/s41598-026-61029-0. Online ahead of print. Sci Rep. 2026. PMID: 42443271 Free article.
Pediatric obesity is a growing public health concern, yet the early neurobiological correlates of obesity risk remain underexplored. ...
Pediatric obesity is a growing public health concern, yet the early neurobiological correlates of obesity risk remain underexplored. …
MR-based skull parametric modeling for blood-brain barrier opening in non-human primates.
Jiménez-Gambín S, Tsitsos F, Bae S, Ji R, Konofagou EE. Jiménez-Gambín S, et al. Sci Rep. 2026 Jul 13. doi: 10.1038/s41598-026-60478-x. Online ahead of print. Sci Rep. 2026. PMID: 42443259 Free article.
Zero echo time (ZTE) magnetic resonance imaging (MRI) is a safe alternative for blood-brain barrier opening (BBBO) planning in non-human primates (NHP), with good contrast for bone imaging. In this study, we applied a classical coordinate-to-coordinate linear-regression me …
Zero echo time (ZTE) magnetic resonance imaging (MRI) is a safe alternative for blood-brain barrier opening (BBBO) planning in non-human …
Genetic or pharmacological inhibition of hepatic TMEM141 attenuates MASH and fibrosis via the ROS-HNF4alpha signaling pathway.
Wang J, Chen CL, Gopoju R, Hu S, Wang Y, Wang H, Batayneh Z, Pan X, Chen YR, Mellott J, Kang P, Gunawardana L, Yin L, Zhang Y. Wang J, et al. Nat Commun. 2026 Jul 13. doi: 10.1038/s41467-026-75425-7. Online ahead of print. Nat Commun. 2026. PMID: 42443224 Free article.
Metabolic dysfunction-associated steatoic liver disease (MASLD) and its advanced form, metabolic dysfunction-associated steatohepatitis (MASH), have become a global epidemic due to obesity and genetic susceptibility. Here, we report transmembrane protein 141 (TMEM141), a p …
Metabolic dysfunction-associated steatoic liver disease (MASLD) and its advanced form, metabolic dysfunction-associated steatohepatitis (MAS …
Oncogenic Ras drives EED degradation and PRC2 dysfunction to promote aggressive squamous cell carcinoma.
Li MY, Houser A, Cheema P, Zheng XY, Restrepo P, Flora P, Zhou Y, Segal-Dalal G, Silberstein E, Zhang X, Schober M, Zheng D, Cohen I, Ji AL, Ezhkova E. Li MY, et al. Nat Commun. 2026 Jul 13. doi: 10.1038/s41467-026-75529-0. Online ahead of print. Nat Commun. 2026. PMID: 42443217 Free article.
Here, we uncover a paradox: although EZH2 is elevated, the PRC2-catalyzed H3K27me3 is profoundly reduced in human SCC and complementary murine models. Mechanistically, we identify that oncogenic Ras signaling causes degradation of the PRC2 subunit EED, destabilizing PRC2 a …
Here, we uncover a paradox: although EZH2 is elevated, the PRC2-catalyzed H3K27me3 is profoundly reduced in human SCC and complementa …
Antibody reveals conformational latch regulating dimerization in β- and γ-herpesvirus proteases.
Zimanyi MA, Hulce KR, Bohn MF, Norman J, Rohweder PJ, Detomasi TC, Cheng Y, Craik CS. Zimanyi MA, et al. Nat Commun. 2026 Jul 13. doi: 10.1038/s41467-026-75438-2. Online ahead of print. Nat Commun. 2026. PMID: 42443199 Free article.
Human herpesvirus (HHV) replication depends on the HHV protease (HHV Pr), an enzyme essential for capsid maturation. ...We isolate Fab5, a conformationally selective antibody from a naive Fab-phage library that recognizes monomeric human cytomegalovirus protease (HC …
Human herpesvirus (HHV) replication depends on the HHV protease (HHV Pr), an enzyme essential for capsid maturation. ...We isolate Fa …
Benzyl alcohol biosynthesis and its subcellular compartmentalization enable scent formation and salicylic acid production.
Lee JH, Huang XQ, Bergman ME, Morgan JA, Liu YK, Tao WA, Dudareva N. Lee JH, et al. Nat Commun. 2026 Jul 13. doi: 10.1038/s41467-026-75494-8. Online ahead of print. Nat Commun. 2026. PMID: 42443198 Free article.
Using a combination of classical biochemical, proteomic and genetic approaches, we demonstrated that two NADPH-dependent benzaldehyde reductases, differing by only three amino acids, are responsible for the formation of benzyl alcohol and its downstream derivatives, benzyl …
Using a combination of classical biochemical, proteomic and genetic approaches, we demonstrated that two NADPH-dependent benzaldehyde …
ERG preserves endothelial identity to limit atherosclerosis.
Botts SR, Scipione CA, Schulz K, Breda LCD, Ellis K, Ho C, Raju S, Prajapati K, Yu K, Khan AB, Polenz CK, Prattas SZ, Hyduk SJ, Cao C, Wythe JD, Robbins CS, Miller CL, Cybulsky MI, Fish JE, Howe KL. Botts SR, et al. Nat Commun. 2026 Jul 13. doi: 10.1038/s41467-026-75287-z. Online ahead of print. Nat Commun. 2026. PMID: 42443196 Free article.
ERG loss also caused early disruption of barrier function, promoting lipid uptake and foam cell accumulation in normally atheroresistant regions. In human atherosclerotic plaques, ERG chromatin accessibility and expression were reduced, with transcriptional changes mirrori …
ERG loss also caused early disruption of barrier function, promoting lipid uptake and foam cell accumulation in normally atheroresistant reg …
MARCKS as a mediator and target for pathological tunneling nanotubes between patient-derived glioblastoma cells and astrocytes.
Nassour-Caswell LC, Ahmed M, Rich-New ST, Schanel TL, Kumar M, Eustace NJ, Rohrbach TD, Jarboe JS, Hicks PH, Anderson JC, Willey CD. Nassour-Caswell LC, et al. Cell Death Dis. 2026 Jul 13. doi: 10.1038/s41419-026-09109-x. Online ahead of print. Cell Death Dis. 2026. PMID: 42443154 Free article.
This dynamic is exemplified in GBM, where TNT-mediated interactions between brain tumor-initiating cells (BTICs) and normal human astrocytes (NHAs) highlight the need to elucidate the molecular mediators underlying this crosstalk. ...
This dynamic is exemplified in GBM, where TNT-mediated interactions between brain tumor-initiating cells (BTICs) and normal human ast …
Placenta models for HIV-1-ART-nicotine comorbidity research: advances and remaining challenges.
Godse S, Bade AN. Godse S, et al. Cell Death Discov. 2026 Jul 13. doi: 10.1038/s41420-026-03249-x. Online ahead of print. Cell Death Discov. 2026. PMID: 42443152 Free article. Review.
Worldwide implementation of antiretroviral therapy (ART) for pregnant women living with human immunodeficiency virus type-1 (HIV-1) has markedly reduced mother-to-child HIV-1 transmission rate to less than one percent. ...
Worldwide implementation of antiretroviral therapy (ART) for pregnant women living with human immunodeficiency virus type-1 (HIV-1) h …
Discrepancies between self-reported alcohol use and breathalyzer results and factors associated with blood alcohol concentration positivity among road traffic injury patients in Cameroon.
Ngekeng S, Oke R, Kibu O, Tanue E, Tendongfor N, Nguefack-Tsague G, Hubbard A, Shoptaw S, Chichom-Mefire A, Juillard C. Ngekeng S, et al. Addiction. 2026 Jul 13. doi: 10.1111/add.70537. Online ahead of print. Addiction. 2026. PMID: 42443067
Participants underwent structured interviews and breathalyzer testing upon presentation to the emergency department within six hours of injury. SETTING: Limbe Regional Hospital and Edea Regional Hospital Annex in Cameroon, both of which are part of the Cameroon Trauma Regi …
Participants underwent structured interviews and breathalyzer testing upon presentation to the emergency department within six hours …
Abbreviated DAPT Regimens Across the Entire Spectrum of Bleeding Risk According to the PRECISE-HBR Score.
Cao D, Oliva A, Mehran R, Sartori S, Feng Y, Gragnano F, van Klaveren D, Angiolillo DJ, Bangalore S, Bhatt DL, Ge J, Hermiller J, Makkar RR, Neumann FJ, Saito S, Picon H, Toelg R, Maksoud A, Chehab BM, Choi JW, Campo G, de la Torre Hernandez JM, Krucoff MW, Kunadian V, Sardella G, Thiele H, Varenne O, Vranckx P, Windecker S, Valgimigli M. Cao D, et al. JACC Cardiovasc Interv. 2026 Jul 13;19(13):1766-1777. doi: 10.1016/j.jcin.2026.04.051. JACC Cardiovasc Interv. 2026. PMID: 42442892
Procedural Strategies for Optimal Transcatheter Aortic Valve Replacement: An International Position Statement.
Maznyczka A, Pilgrim T, Hildick-Smith D, Mangieri A, Latib A, Abdel-Wahab M, Alkhouli M, Webb JG, Reardon MJ, Herrmann HC, Blackman DJ, Nombela-Franco L, Rudolph TK, Wykrzykowska JJ, Barbanti M, Joner M, Généreux P, Russell K, Saint-Etienne C, Akodad M, Kobari Y, Meier D, Van Mieghem N, Rogers T, Kodali S, Ohno Y, Angellotti D, Prendergast B, Dvir D, Mylotte D, Tchétché D, Piazza N, De Backer O. Maznyczka A, et al. JACC Cardiovasc Interv. 2026 Jul 13;19(13):1713-1734. doi: 10.1016/j.jcin.2026.04.049. JACC Cardiovasc Interv. 2026. PMID: 42442887 Review.
Risk Factors Associated with Delivery Hospitalization Pulmonary Embolism.
Wang R, Agarwal J, Huang Y, Wen T, D'Alton M, Friedman AM. Wang R, et al. Am J Perinatol. 2026 Jul 13. doi: 10.1055/a-2911-5301. Online ahead of print. Am J Perinatol. 2026. PMID: 42442713
OBJECTIVE: The objectives of this study were to analyze trends in obstetric PE and to determine how clinical risk factors have contributed to changes in pulmonary embolism risk over the study period. STUDY DESIGN: The 2000-2021 National Inpatient Sample was used for this c …
OBJECTIVE: The objectives of this study were to analyze trends in obstetric PE and to determine how clinical risk factors have contributed t …
Outcomes for persons with triple-class resistant HIV and a history of virologic failure.
Ingle SM, Bonnet F, Wittkop L, Calmy A, Teira R, Rebeiro PF, Crane HM, Stephan C, van der Valk M, Boesecke C, Touloumi G, Gill MJ, Grabmeier-Pfistershammer K, Garcia F, Ceccherini-Silberstein F, Burkholder G, Trickey A, Sterne JAC, Hessamfar M; Antiretroviral Therapy Cohort Collaboration (ART-CC). Ingle SM, et al. Int J Antimicrob Agents. 2026 Jul 13:107925. doi: 10.1016/j.ijantimicag.2026.107925. Online ahead of print. Int J Antimicrob Agents. 2026. PMID: 42442619
Emergence of Reassortant Crimean-Congo Hemorrhagic fever virus lineages, Pakistan, 2023-2024.
Umair M, Jamal Z, Ali Q, Hakim R, Rana MS, Javed Y, Bugti AR, Ayub A, Sabeen F, Waheed Y, Salman M. Umair M, et al. Infect Genet Evol. 2026 Jul 13:105988. doi: 10.1016/j.meegid.2026.105988. Online ahead of print. Infect Genet Evol. 2026. PMID: 42442443
Crimean-Congo hemorrhagic fever virus (CCHFV) remains endemic in Pakistan, yet whole-genome data are limited. During 2023-2024 national surveillance, 151 suspected cases were screened by qRT-PCR; 23 were confirmed at the NIH, Islamabad. ...These findings underscore …
Crimean-Congo hemorrhagic fever virus (CCHFV) remains endemic in Pakistan, yet whole-genome data are limited. During 2023-2024 national …
HIV acquisitions, safety, and pharmacokinetics of lenacapavir for HIV pre-exposure prophylaxis in pregnant and lactating women (PURPOSE 1): a substudy of a phase 3, randomised controlled trial.
Bekker LG, Moodley D, Diallo DD, Harkoo I, Kigozi G, Kiwanuka N, Louw CE, Malahleha M, Mworeko L, Palanee-Phillips T, Panchia R, Singh N, Puryear SB, Arora P, Baeten JM, Brown A, Carter CC, Imperial M, Ling J, Singh R, Wong P, Das M, Kiweewa FM. Bekker LG, et al. Lancet HIV. 2026 Jul 13:S2352-3018(26)00112-8. doi: 10.1016/S2352-3018(26)00112-8. Online ahead of print. Lancet HIV. 2026. PMID: 42442378
The role of sweat chloride in determining CFTR protein restoration in people with cystic fibrosis.
Zemanick ET, Graeber SY, Castellani C, Cutting GR, Fajac I, Konstan MW, Linnemann RW, McKone EF, Metcalf A, Solomon GM, Taylor-Cousar JL, Mayer-Hamblett N, Mall MA. Zemanick ET, et al. Lancet Respir Med. 2026 Jul 13:S2213-2600(26)00159-1. doi: 10.1016/S2213-2600(26)00159-1. Online ahead of print. Lancet Respir Med. 2026. PMID: 42442377 Review.
For many people with cystic fibrosis with responsive variants and drug access, treatment with CFTR modulators increases CFTR function, reduces sweat chloride concentrations, and improves lung health and quality of life. In clinical trials, average sweat chloride reduction …
For many people with cystic fibrosis with responsive variants and drug access, treatment with CFTR modulators increases CFTR function, reduc …
Reproductive health guidance for the cystic fibrosis community: a Cystic Fibrosis Foundation Position Paper.
Jain R, Taylor JL, Kazmerski TM, Lonabaugh K, Trimble A, Velez Leitner D, Foil K, Hong G, Johns WB, Kolarova T, Meier E, Perry A, Singh KE, Stahl C, Szentpetery S, Weiss MS, West NE, Wilson A, Wright B, Brown AW, Hempstead SE, Lomas P, Middleton PG, Shteinberg M, Felton I, Roe AH. Jain R, et al. Lancet Respir Med. 2026 Jul 13:S2213-2600(26)00120-7. doi: 10.1016/S2213-2600(26)00120-7. Online ahead of print. Lancet Respir Med. 2026. PMID: 42442376 Review.
The Cystic Fibrosis Foundation organised a multidisciplinary committee to develop this Position Paper to outline current knowledge and best practices in reproductive health care for individuals with cystic fibrosis. Working groups reviewed the literature and provided relev …
The Cystic Fibrosis Foundation organised a multidisciplinary committee to develop this Position Paper to outline current knowledge and best …
Dementia prevention in Latin America and the Global South.
Fortea J, Ikanga J, de Paula França Resende E. Fortea J, et al. Lancet. 2026 Jul 13:S0140-6736(26)01373-5. doi: 10.1016/S0140-6736(26)01373-5. Online ahead of print. Lancet. 2026. PMID: 42442375 No abstract available.
Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind, multicentre, randomised controlled trial.
Crivelli L, Suemoto CK, Sosa AL, Lopera F, Aguillón D, Allegri RF, Nitrini R, Calandri IL, Velilla-Jiménez L, Yassuda MS, Acosta-Baena N, Salinas RM, Charamelo A, Derio CD, Acosta DM, León-Salas JM, Duque-Peñailillo L, Cusicanqui MI, Custodio N, Anchia-Alfaro A, Núñez-Herrera A, Rubens A, Leites A, Vigil-Martínez A, Damian A, Flores-Blanco BM, Custodio B, Laforcada C, Márquez C, Friedlaender CV, Espinoza-Cruz CG, Cañadas C, Peixoto C, Muñoz DH, Slezak DF, Felix E, Aguirre-Salvador E, Surace EI, Mariani F, De La Torre GR, Verástegui G, Keller G, Peixoto GH, Morilla HA, Jiménez-Velázquez IZ, More JY, Rodríguez JF, Tosatti JAG, de Faria Rocha JV, Saldarriaga-Hernández J, Huilca JC, García-Molina JT, Martínez-Galindo JG, Duran JC, Rodriguez JG, Gomes KB, César-Freitas KG, Agüero K, Mora-Villalobos L, Asprilla LO, de Souza LC, Soto L, Cortabarría L, Baldeón L, Carreira LL, Marin-Buitrago L, Moreno MC, Barbosa MT, Torheim M, Magalhães MAZ, da Graça Morais Martin M, Martin ME, Torres MF, Menéndez M, Hernandez MA, Granizo MS, Gutiérrez M, Corvalán N, Mora PJ, Peguero P, Ramírez-Santos R, Fernández RS, Montesinos R, Ospina-Henao S, Montes SY, Santero S, Brucki SMD, Josephy-Hernandez S, Vaz… See abstract for full author list ➔ Crivelli L, et al. Lancet. 2026 Jul 13:S0140-6736(26)01278-X. doi: 10.1016/S0140-6736(26)01278-X. Online ahead of print. Lancet. 2026. PMID: 42442374
The SLI provided structured multidomain lifestyle interventions with supervised support and monitoring; FLI offered health advice. Primary outcomes were trial feasibility (evaluated using selected RE-AIM measures: Reach, Implementation, and Maintenance) and the interventio …
The SLI provided structured multidomain lifestyle interventions with supervised support and monitoring; FLI offered health advice. Pr …
Understanding protein ISGylation, a multifaceted posttranslational modification.
Shirley DJ, Yoo E. Shirley DJ, et al. Cell Chem Biol. 2026 Jul 13:S2451-9456(26)00230-8. doi: 10.1016/j.chembiol.2026.06.006. Online ahead of print. Cell Chem Biol. 2026. PMID: 42442365 Review.
Dysregulated ISGylation is implicated in cancer, infection, neurodegenerative disorders, and inflammatory diseases, underscoring its broad pathophysiological relevance....
Dysregulated ISGylation is implicated in cancer, infection, neurodegenerative disorders, and inflammatory diseases, underscoring its …
Perfluorooctanoic acid and cancer incidence: an updated investigation of a cohort in the mid-Ohio Valley.
Hofmann JN, Tan Y, Barry V, Taylor A, Winquist A, Hyer M, Graubard BI, Steenland K, Silverman DT. Hofmann JN, et al. Environ Int. 2026 Jul 10;214:110405. doi: 10.1016/j.envint.2026.110405. Online ahead of print. Environ Int. 2026. PMID: 42442238
BACKGROUND: Perfluorooctanoic acid (PFOA) has been classified as a human carcinogen based partly on limited epidemiologic evidence of increased kidney and testicular cancer risk. ...We also observed positive associations with thyroid cancer, particularly amon …
BACKGROUND: Perfluorooctanoic acid (PFOA) has been classified as a human carcinogen based partly on limited epidemiologic evidence of …
Multiomic characterization of DNA released after airway exposure to allergens and nanoparticles reveals selective export of repetitive and fragile site DNA.
Law K, Srisomboon Y, Iijima K, Faulk C, Kita H, O'Grady SM. Law K, et al. Physiol Genomics. 2026 Jul 13. doi: 10.1152/physiolgenomics.00029.2026. Online ahead of print. Physiol Genomics. 2026. PMID: 42441982
Nanopore sequencing along with a multi-omics approach were employed to analyze fragments of extracellular DNA (eDNA) in human and mouse airway epithelial cells and bronchoalveolar lavage fluid from mice. We show that eDNA release following Alternaria or PEI exposure produc …
Nanopore sequencing along with a multi-omics approach were employed to analyze fragments of extracellular DNA (eDNA) in human and mou …
Glucagon-Like Peptide-1 Receptor Agonists and Risk for Ischemic Optic Neuropathy : A Target Trial Emulation.
Reynolds KR, O'Malley KM, Roy JA, Dave CV. Reynolds KR, et al. Ann Intern Med. 2026 Jul 14. doi: 10.7326/ANNALS-25-00860. Online ahead of print. Ann Intern Med. 2026. PMID: 42441967
DESIGN: Observational emulation of a target trial. SETTING: Large U.S.-based commercial claims database (January 2017 to December 2022). PARTICIPANTS: Patients aged 18 to 65 years with type 2 diabetes initiating a GLP-1RA, an SGLT2i, or a DPP4i. ...Observed differen …
DESIGN: Observational emulation of a target trial. SETTING: Large U.S.-based commercial claims database (January 2017 to Decem …
Virtual Sustained Tobacco Treatment for Patients With Cancer: A Randomized Controlled Trial (ECOG-ACRIN: EAQ171CD) Within the National Cancer Institute Community Oncology Research Program.
Park ER, Sicks JD, Goshe BM, Gareen IF, Herman BA, Taurone A, Bittig S, Walter AW, Regan S, Rosen R, Durieux N, Rasmussen AW, Levy DE, Nicolosi G, Muzikansky A, Thompson MA, Lui M, Malloy L, Gonzalez I, Finkelstein-Fox L, Munson ND, Greenwade MM, King DM, Jenigiri B, Burnette BL, Throckmorton AD, Tingen MS, Carlos RC, Wagner LI, Ostroff JS. Park ER, et al. J Clin Oncol. 2026 Jul 13:JCO2502267. doi: 10.1200/JCO-25-02267. Online ahead of print. J Clin Oncol. 2026. PMID: 42441935
PURPOSE: Persistent smoking among patients diagnosed with cancer is associated with adverse clinical outcomes, yet tobacco treatment has not been integrated into community oncology settings. ...METHODS: This randomized controlled trial compared the effectiveness of sustain …
PURPOSE: Persistent smoking among patients diagnosed with cancer is associated with adverse clinical outcomes, yet tobacco treatment …
Discovery of Novel LRPPRC Inhibitors Featuring a Biphenyl-Acylhydrazone Scaffold with Potent Broad-Spectrum Antitumor Activity.
Ren H, Liu J, Wang D, Zhang J, Zhao J, Lai X, Lu J, Zhou W, Liang X, Fang X, Liu H. Ren H, et al. J Med Chem. 2026 Jul 13. doi: 10.1021/acs.jmedchem.6c00936. Online ahead of print. J Med Chem. 2026. PMID: 42441917
Notably, 3o downregulated downstream OXPHOS subunits and ATP synthase, eliciting broad antiproliferative effects, particularly in refractory and drug-resistant A549, BXPC-3, and NCI-H1975 cells (IC(50) = 0.54, 0.27, and 1.39 muM, respectively). In PC9 and HCT116 xenografts …
Notably, 3o downregulated downstream OXPHOS subunits and ATP synthase, eliciting broad antiproliferative effects, particularly in refractory …
Developmental divergence in voice-reward circuitry differentiates autistic from typically developing children and adolescents.
Abrams DA, Leipold S, Odriozola P, Baker AE, Padmanabhan A, Phillips JM, Menon V. Abrams DA, et al. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2601227123. doi: 10.1073/pnas.2601227123. Epub 2026 Jul 13. Proc Natl Acad Sci U S A. 2026. PMID: 42441858
Human voice processing is a primary driver of social learning and communication, but it remains understudied in the autism literature, particularly as it relates to neurodevelopmental change. ...More broadly, results suggest that individual differences in social …
Human voice processing is a primary driver of social learning and communication, but it remains understudied in the autism lit …
Enteroendocrine cells wire the gut-brain vagal axis.
Runyon A, Zhang P, Fischer AJ, Nonet ML, Lillesaar C, Ye L. Runyon A, et al. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2600339123. doi: 10.1073/pnas.2600339123. Epub 2026 Jul 13. Proc Natl Acad Sci U S A. 2026. PMID: 42441856
Although recent research has greatly enhanced our understanding of the function of vagal sensory neurons, little is known about what guides the vagal sensory nerve fibers to innervate the intestine and form a complex gut-brain sensory network. Here, using zebrafish genetic …
Although recent research has greatly enhanced our understanding of the function of vagal sensory neurons, little is known about what guides …
Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase.
Obara K, Okada H, Tan G, Ohnuki S, Suzuki G, Ohtake H, Kubo K, Ghanegolmohammadi F, Ishizaka S, Yashiroda Y, Okita A, Mishiro-Sato E, Suzuki K, Tamura Y, Ashine R, Ikeda Y, Kamura T, van Leeuwen J, Andrews B, Bi E, Noda NN, Boone C, Ohya Y. Obara K, et al. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2612792123. doi: 10.1073/pnas.2612792123. Epub 2026 Jul 13. Proc Natl Acad Sci U S A. 2026. PMID: 42441850
By integrating quantitative morphological profiling with global genetic interaction analysis, we found that PBR1 function converges on cell-wall biosynthesis and closely parallels that of FKS1. ...
By integrating quantitative morphological profiling with global genetic interaction analysis, we found that PBR1 function converges o …
Paintable on-skin dry electrodes with robust skin and device connection for wireless sensing and human-machine interfaces.
Zhang W, Xin X, Wang Y, Zhang X, Zhang S, Yuan Y, Xia S, Abdullah AM, Zohra FT, Li B, Yang JY, Dutta A, Liu Z, Lima ABP, Yan S, Zhong J, Chuang CH, Cheng H. Zhang W, et al. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2615835123. doi: 10.1073/pnas.2615835123. Epub 2026 Jul 13. Proc Natl Acad Sci U S A. 2026. PMID: 42441849
Reliable and continuous electrophysiological recording is important for health monitoring and human-machine interactions. However, most existing epidermal electrodes suffer from either limited skin-electrode contact during skin deformation and sweating, or unstable …
Reliable and continuous electrophysiological recording is important for health monitoring and human-machine interactions. Howe …
Pseudokinase-converting mutation in protein kinase C alpha drives chordoid glioma by pathway rewiring.
Bellamy C, Tovell H, Kao TH, Kornev A, Letourneur Q, Arslan J, Schwaighofer S, Baffi TR, Dingli F, Loew D, Lerond J, Liva S, Izac B, Andrieu M, Adle-Biassette H, Barnier JV, Stefan E, Taylor SS, Sanson M, Newton AC, Bielle F. Bellamy C, et al. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2524934123. doi: 10.1073/pnas.2524934123. Epub 2026 Jul 13. Proc Natl Acad Sci U S A. 2026. PMID: 42441840
The mutation is invariably an Asp to His substitution, suggesting a unique function beyond catalytic inactivation associated with other cancer-associated PKCalpha mutations. Here, we show that this mutation converts PKCalpha into a pseudokinase, abolishing catalytic activi …
The mutation is invariably an Asp to His substitution, suggesting a unique function beyond catalytic inactivation associated with other c …
Assessing the abuse liability of U.S. Food and Drug Administration-authorized electronic nicotine delivery systems: Impact of nicotine flux, flavor, and menthol cigarette smoking status.
Ogunleye EO, Bono RS, Imran R, Gaitan N, Lipato T, Barnes AJ, Cobb CO. Ogunleye EO, et al. Exp Clin Psychopharmacol. 2026 Jul 13. doi: 10.1037/pha0000861. Online ahead of print. Exp Clin Psychopharmacol. 2026. PMID: 42441607
The U.S. Food and Drug Administration has authorized 41 electronic nicotine delivery systems (ENDS) that meet its public health standard. ...Findings support further investigation on menthol-flavored, higher flux ENDS for public health benefit. (PsycIn …
The U.S. Food and Drug Administration has authorized 41 electronic nicotine delivery systems (ENDS) that meet its public he …
Clinical Profile of Neurofibromatosis Type 1: Paediatric Patients from a Tertiary Care Centre.
Mendiratta V, Verma B, Bindal A. Mendiratta V, et al. Indian J Dermatol. 2026 Jul-Aug;71(4):306-309. doi: 10.4103/ijd.ijd_389_25. Epub 2026 Jun 30. Indian J Dermatol. 2026. PMID: 42441148 Free PMC article.
Neurofibromatosis Type 1 (NF1) is a genetic disorder involving multiple organ systems, primarily the nervous system and skin. ...Children fulfilling the NIH diagnostic criteria for NF1 were included. Clinical features, imaging findings, and systemic associations wer …
Neurofibromatosis Type 1 (NF1) is a genetic disorder involving multiple organ systems, primarily the nervous system and skin. ...Chil …
Falls Do Not Just Break Bones--They Break Lives: World Spinal Cord Injury Day (September 5, 2025) and Indian Perspectives.
Swarnakar R. Swarnakar R. Cureus. 2026 Jun 5;18(6):e110329. doi: 10.7759/cureus.110329. eCollection 2026 Jun. Cureus. 2026. PMID: 42441090 Free PMC article.
Effective fall prevention requires a multipronged approach that combines home and community safety interventions, medical screening, occupational safeguards, and the integration of technology such as wearable devices and mobile applications. Equally important is the role of he …
Effective fall prevention requires a multipronged approach that combines home and community safety interventions, medical screening, occupat …
Interfacial effects on charge separation and photocatalytic activity of ZnO photocatalysts modified with ionic liquids.
Levene MB, Blanco JJM, Mapossa AB, Almirão de Jesus JP, La Porta FA, Padilha JC, Sousa Góes M. Levene MB, et al. RSC Adv. 2026 Jul 6. doi: 10.1039/d6ra03134j. Online ahead of print. RSC Adv. 2026. PMID: 42441026 Free PMC article.
The computed interaction energies and non-covalent interaction (NCI) analyses confirmed the strong interfacial anchoring of the IL, while excited-state and frontier molecular orbital descriptors indicated electronic effects consistent with improved charge separation. ...
The computed interaction energies and non-covalent interaction (NCI) analyses confirmed the strong interfacial anchoring of the IL, w …
Unveiling acetamide coupled benzothiazole hydrazones as potential anti-proliferative agents: an experimental and computational approach.
Imtiaz M, Persoons L, Daelemans D, De Jonghe S, Hameed S. Imtiaz M, et al. RSC Adv. 2026 Jul 6. doi: 10.1039/d6ra03835b. Online ahead of print. RSC Adv. 2026. PMID: 42440848 Free PMC article.
A series of benzothiazole acetamide hydrazones (8a-p) was synthesized and evaluated for anti-proliferative activity against various human cancer cell lines, including a pancreatic ductal adenocarcinoma (CAPAN-1), a colorectal carcinoma (HCT-116), a leukemia (HL60), …
A series of benzothiazole acetamide hydrazones (8a-p) was synthesized and evaluated for anti-proliferative activity against various human …
The effect of probiotic supplements on cognitive outcomes and neuroplasticity in elderly ischemic stroke survivors.
Zheng X, Chen W, Hong K, Chen J, Lin Y, Yang J. Zheng X, et al. Front Neurol. 2026 Jun 22;17:1833163. doi: 10.3389/fneur.2026.1833163. eCollection 2026. Front Neurol. 2026. PMID: 42440737 Free PMC article.
METHODS: The study included 223 elderly ischemic stroke survivors treated between March 2021 and February 2024, divided into two groups based on treatment modalities: the Conventional Group (n = 117) receiving standard enteral nutrition, and the Supplement Group (n = 106) receivi …
METHODS: The study included 223 elderly ischemic stroke survivors treated between March 2021 and February 2024, divided into two groups base …
Characterization and preliminary heterosis evaluation of novel wheat genetically divergent populations.
Wu Z, Sun J, Lou H, Xu L, Gan C, Liu W, Zhang Y, Liang R, Ni Z, Sun Q. Wu Z, et al. Front Plant Sci. 2026 Jun 22;17:1824151. doi: 10.3389/fpls.2026.1824151. eCollection 2026. Front Plant Sci. 2026. PMID: 42440667 Free PMC article.
Furthermore, 23 elite lines derived from different recurrent selection populations were used as parents in an incomplete NCII (inter-population crosses) and a full NCI(intra-population crosses) design to evaluate their genetic distance and the heterotic performance. …
Furthermore, 23 elite lines derived from different recurrent selection populations were used as parents in an incomplete NCII (inter-populat …
High resolution cryo-EM structure of the Pseudomonas aeruginosa OprM multidrug efflux pump provides target for rational inhibitor design.
Ratliff AC, Botos I, Putti AM, Patil PP, Ramkumar A, Ghirlando R, Dekker JP, Buchanan SK. Ratliff AC, et al. J Struct Biol X. 2026 Jun 27;14:100152. doi: 10.1016/j.yjsbx.2026.100152. eCollection 2026 Dec. J Struct Biol X. 2026. PMID: 42440500 Free PMC article.
OprM is the outer membrane channel component of resistance-nodulation-division (RND) efflux pumps in Pseudomonas aeruginosa, a high-priority human pathogen. OprM-dependent pumps play diverse roles in bacterial physiology and mediate resistance to critical antibiotic …
OprM is the outer membrane channel component of resistance-nodulation-division (RND) efflux pumps in Pseudomonas aeruginosa, a high-p …
Synthetic developmental engineering of human liver organogenesis.
Taheri MN, Xiang Y, Ebrahimkhani MR. Taheri MN, et al. Development. 2026 Jul 1;153(13):dev205040. doi: 10.1242/dev.205040. Epub 2026 Jul 13. Development. 2026. PMID: 42440359 Review.
In this Review, we discuss liver development in the human embryo and current models that are routinely used for generating liver organoids in vitro as well as their limitations. ...Together, these approaches pave the way for next-generation multicellular human stem …
In this Review, we discuss liver development in the human embryo and current models that are routinely used for generating liver orga …
PDA (Privacy-Preserving Distributed Algorithms) in action: ten principles for high-quality multi-site clinical evidence generation.
Chen Y, Tong J, Lu Y, Duan R, Luo C, Suchard MA, Ryan PB, Williams AE, Holmes JH, Moore JH, Xu H, Lu Y, Carroll RJ, Zeger SL, Hripcsak G, Schuemie MJ. Chen Y, et al. J Am Med Inform Assoc. 2026 Jul 13:ocag119. doi: 10.1093/jamia/ocag119. Online ahead of print. J Am Med Inform Assoc. 2026. PMID: 42440280
Over the last 10 years, Privacy-Preserving Distributed Algorithms (PDA) have been developed and utilized in numerous national and international real-world studies spanning diverse domains, from comparative effectiveness research, target trial emulation, to healthcare deliv …
Over the last 10 years, Privacy-Preserving Distributed Algorithms (PDA) have been developed and utilized in numerous national and int …
Occupational Risk of Low-Level Blast Exposure and Health Outcomes: A Longitudinal Study of Postdeployment Army Enlisted Active Duty Soldiers.
Adams RS, Huntington N, Carpenter J, Linton A, Moresco N, Dams-O'Connor K, Kumar RG, Highland KB, Larson MJ. Adams RS, et al. J Head Trauma Rehabil. 2026 Jun 26. doi: 10.1097/HTR.0000000000001191. Online ahead of print. J Head Trauma Rehabil. 2026. PMID: 42440265
OBJECTIVE: Evaluate the relationship between risk of occupational low-level blast (LLB) exposure and health outcomes (ie, substance use disorder, long-term opioid receipt, headaches, and back pain). ...CONCLUSION: Study results add to the existing research underscoring the …
OBJECTIVE: Evaluate the relationship between risk of occupational low-level blast (LLB) exposure and health outcomes (ie, substance u …
Evaluation of Bronchial Receptors with Concentration-Response Curves, Bitterness Assessment, and Computer Simulations.
Bouzid M, Smati H, Ben Torkia Y, Bayouth S, Sakly A, Ben Lamine A. Bouzid M, et al. Cell Biochem Biophys. 2026 Jul 13. doi: 10.1007/s12013-026-02117-w. Online ahead of print. Cell Biochem Biophys. 2026. PMID: 42440246
This research aims to explore the human-like taste response of three bitter molecules (chloroquine, denatonium, and saccharin) on the human bronchi receptor T2R agonist using a statistical physics approach. ...The type and strength of interactions were identified us …
This research aims to explore the human-like taste response of three bitter molecules (chloroquine, denatonium, and saccharin) on the …
Quantifying Structural Changes in Cultured Neurons Using Fractal Analysis.
Rv AA, Karri S, Kabirova M, Firer M, Michaelevski I. Rv AA, et al. Neuroinformatics. 2026 Jul 13;24(3):44. doi: 10.1007/s12021-026-09802-4. Neuroinformatics. 2026. PMID: 42440205

To integrate multivariate features, we constructed a composite Neurite Complexity Index (NCI) incorporating branching, neurite length, and distribution-sensitive descriptors (R2 0.98; F(4,106) = 89.6, p < 1 10-(184)). FD showed strong convergence with the NCI

…
To integrate multivariate features, we constructed a composite Neurite Complexity Index (NCI) incorporating branching, neurite length …
Plasticizing Diabetes Care: The Metabolic Threat of Plastic-Associated Endocrine Disruptors and Micro-/Nanoplastics in Clinical Medicine.
Sargis RM, Reutrakul S, Trasande L, Nadal A. Sargis RM, et al. Curr Diab Rep. 2026 Jul 13;26(1):21. doi: 10.1007/s11892-026-01635-4. Curr Diab Rep. 2026. PMID: 42440155 Review.
Plastic-associated EDCs and MNPs remain an underappreciated metabolic health threat. Mitigating the deleterious impacts of plastics on human and planetary health requires concerted actions from manufacturers, scientists, policymakers, professional organizatio …
Plastic-associated EDCs and MNPs remain an underappreciated metabolic health threat. Mitigating the deleterious impacts of plastics o …
Efficacy of Splenectomy for Hematologic Malignancies: A Retrospective Cohort Study.
Mohammed H, Waheed MT, Trisal V, Paz IB, Melstrom L, Siddiqi T, Aribi A, Shouse G, Popplewell LL, Forman SJ, Mei MG, Al Malki MM, Ali H, Raoof M. Mohammed H, et al. Ann Surg. 2026 Jun 26. doi: 10.1097/SLA.0000000000007139. Online ahead of print. Ann Surg. 2026. PMID: 42440087
METHODS: This retrospective study included consecutive patients with hematologic disorders who underwent splenectomy at an NCI-designated comprehensive cancer center between 2009 and 2024. Patients were grouped by indication as lymphoid or myeloid; patients with ben …
METHODS: This retrospective study included consecutive patients with hematologic disorders who underwent splenectomy at an NCI-design …
Estimating Utility Values Using the DMD-QoL: A Disease-Specific Preference-Based Measure for Duchenne Muscular Dystrophy (DMD).
Bever A, Szabo SM, Jayasinghe P, Feeny D, Neumann PJ, Malone DC, Iannaccone ST, Gooch KL, Audhya IF. Bever A, et al. Adv Ther. 2026 Jul 13. doi: 10.1007/s12325-026-03700-6. Online ahead of print. Adv Ther. 2026. PMID: 42440040
Participants were classified into health states based on upper and lower limb function. Mean utility and change over 12 months were calculated by baseline health state and respondent type; change in utility was also estimated among those in whom declining ambulatory …
Participants were classified into health states based on upper and lower limb function. Mean utility and change over 12 months were c …
Uncontrolled Hypertension Prevalence, Characteristic Profiles, and Risk of Cardiorenal and Metabolic Outcomes: Insights from the EnligHTN Study.
McCormack T, Ben Dor NR, Norris T, Giannoula A, Coto E, Rhodes KM, Franzén S, Suárez Fernández C, Weil J, Bech JN, Bhalla V. McCormack T, et al. Adv Ther. 2026 Jul 13. doi: 10.1007/s12325-026-03681-6. Online ahead of print. Adv Ther. 2026. PMID: 42440039
Adults with a hypertension diagnosis after 2018 and a BP measurement after receiving 2 antihypertensives for 30 days (index date) were included. uHTN was defined based on index BP according to national guidelines (US: 130/80 mmHg; other countries: 140/90 mmHg). Dat …
Adults with a hypertension diagnosis after 2018 and a BP measurement after receiving 2 antihypertensives for 30 days (index date) were i …
Applications of Stem Cell-Derived Islets and Emerging Experimental Platforms to Understand Diabetes.
Mukherjee N, Millman JR. Mukherjee N, et al. Diabetes. 2026 Jul 13:db260013. doi: 10.2337/db26-0013. Online ahead of print. Diabetes. 2026. PMID: 42439827 Review.
We also discuss exciting emerging approaches that expand investigations beyond pancreatic endocrine cells to encompass nonendocrine cell types in the pancreas, offering a unique bird's-eye view into pancreatic biology and insights into cellular cross talk in health and dis …
We also discuss exciting emerging approaches that expand investigations beyond pancreatic endocrine cells to encompass nonendocrine cell typ …
Urinary Profiles of Exosomal LINE-1 mRNA and Associated miRNAs in Non-Small-Cell Lung Cancer.
Hassanin AAI, Ramos KS. Hassanin AAI, et al. Cells. 2026 Jul 7;15(13):1231. doi: 10.3390/cells15131231. Cells. 2026. PMID: 42439705 Free article.
Lung cancer remains the leading cause of cancer-related mortality worldwide in both males and females. ...Recent studies from our group demonstrated that the LINE-1 mRNA and associated miRNA cargo of plasma exosomes can be used as sensitive and specific diagnostic a …
Lung cancer remains the leading cause of cancer-related mortality worldwide in both males and females. ...Recent studies from …
P38γ Promotes Tumorigenesis Through Activating Immune Evasion.
Chandrashekar N, Qi XM, Chen G. Chandrashekar N, et al. Cells. 2026 Jul 7;15(13):1226. doi: 10.3390/cells15131226. Cells. 2026. PMID: 42439700 Free PMC article. Review.
This paper will review recently published and unpublished studies of p38gamma in programming immune evasion in breast cancer, pancreatic cancer, and colon cancer to promote tumorigenesis. First, we show that p38gamma is an oncogene that transforms breast epit …
This paper will review recently published and unpublished studies of p38gamma in programming immune evasion in breast cancer, pancrea …
Beyond VEGF: AEG-1/MTDH as a Systems-Level Orchestrator of Angiogenesis in Hepatocellular Carcinoma.
Younis RM, Rodriguez KA, Sarkar D. Younis RM, et al. Cells. 2026 Jul 3;15(13):1214. doi: 10.3390/cells15131214. Cells. 2026. PMID: 42439688 Free article. Review.
Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide and is characterized by extensive vascularization, aggressive progression, and limited therapeutic responsiveness. ...
Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide and is characterized by extens …
1,25-Dihydroxyvitamin D Induces a NURR1-Tyrosine Hydroxylase Transcriptional Axis Modulated by Rexinoid/RXR Signaling in Parkinson's Disease-Relevant Human Neural Cell Models.
Sausedo MA, Mallick S, Sabir ZL, Livingston S, Nguyen QT, Doost ME, Wagner CE, Marshall PA, Haussler CA, Haussler MR, Jurutka PW. Sausedo MA, et al. Cells. 2026 Jul 3;15(13):1210. doi: 10.3390/cells15131210. Cells. 2026. PMID: 42439684 Free article.
Herein we report that TH mRNA is significantly induced (2.5-fold) and NURR1 mRNA is induced 9.3-fold by 10 nM 1,25D in differentiated human SH-SY5Y neuroblastoma cells. Similar results were observed in human U87 glioblastoma cells (TH, 2.6-fold; NURR1, 3.6-fold). Co …
Herein we report that TH mRNA is significantly induced (2.5-fold) and NURR1 mRNA is induced 9.3-fold by 10 nM 1,25D in differentiated hum …
MAFA: A Master Regulator of β-Cell Maturation and Function.
Johnson L, Maurer MA, Cha J. Johnson L, et al. Cells. 2026 Jul 1;15(13):1199. doi: 10.3390/cells15131199. Cells. 2026. PMID: 42439674 Free article. Review.
In this review, we summarize the current understanding of MAFA on beta-cell maturation and function in both the mouse and human. This includes structural features of the MAFA protein, regulation of MAFA transcription, post-translational modifications, and emerging areas of …
In this review, we summarize the current understanding of MAFA on beta-cell maturation and function in both the mouse and human. This …
Generation of Blood Vascular Endothelial-Neural 3D Organoids by Serial Induction of Differentiation on Human iPSC-Derived Embryoid Bodies.
Wang T, Bagnell A, McDonald V, Gastfriend BD, Steiner JP, Elkahloun AG, Johnson K, Langston RG, Cookson MR, Nath A. Wang T, et al. Cells. 2026 Jun 30;15(13):1192. doi: 10.3390/cells15131192. Cells. 2026. PMID: 42439668 Free article.
However, these approaches could miss the developmental interactions between angiogenesis and neurogenesis in the human brain. To reconstitute a 3D organoid mimicking the in vivo development of neural and vascular endothelial cells, we cultured iPSC-derived embryoid bodies …
However, these approaches could miss the developmental interactions between angiogenesis and neurogenesis in the human brain. To reco …
SNED1 modulates ECM architecture and cell proliferation via its LDV integrin-binding motif.
Pally D, Leverton L, Jones A, Naba A. Pally D, et al. J Cell Sci. 2026 Jul 13:jcs.264885. doi: 10.1242/jcs.264885. Online ahead of print. J Cell Sci. 2026. PMID: 42439511
Understanding how ECM-receptor interactions regulate matrix assembly is critical to uncover how alterations of the ECM cause or accompany congenital diseases, cancer, or fibrosis. SNED1 is an understudied ECM protein with roles in development and metastasis. ...Moreover, S …
Understanding how ECM-receptor interactions regulate matrix assembly is critical to uncover how alterations of the ECM cause or accompany co …
Molecular Acrobats: How CHD Remodelers Shape the Genetic Playground to License Cell Identity.
Özdemir İ, Hainer SJ. Özdemir İ, et al. Bioessays. 2026 Jul;48(7):e70158. doi: 10.1002/bies.70158. Bioessays. 2026. PMID: 42439481 Free PMC article. Review.
In eukaryotes, DNA is not a naked repository of genetic information but is tightly wound around histone octamers to form nucleosomes. While this packaging solves the spatial problem of fitting 2 meters of DNA into a microscopic nucleus, it creates a massive accessibility p …
In eukaryotes, DNA is not a naked repository of genetic information but is tightly wound around histone octamers to form nucleosomes. …
Cyclic Mechanical Loading of Cardiomyocytes via Pressure-Driven Non-Planar Membrane Deformation in a Bioreactor System.
Mansoor H, Juul G, Patel J, Pradhan H, Hepner G, Jewell J, Bardin M, Slusser R, Glezer A, Klouda L, Tanyeri M, Saraf A. Mansoor H, et al. Adv Sci (Weinh). 2026 Jul 13:e23820. doi: 10.1002/advs.202523820. Online ahead of print. Adv Sci (Weinh). 2026. PMID: 42439440
Applied pressure was quantitatively related to spatial membrane strain through three-dimensional membrane reconstruction, enabling characterization of the mechanical environment at the cell-substrate interface. Human induced pluripotent stem cell-derived cardiomyocytes (hi …
Applied pressure was quantitatively related to spatial membrane strain through three-dimensional membrane reconstruction, enabling character …
Optimizing Antihypertensive Care for Tanzanians Living With HIV: Effectiveness Outcomes From the COACH Pilot Trial.
Hertz JT, Rahim F, Wang C, Vaidyanathan A, Wanda L, Sakita FM, Mmbaga BT, Kweka GL, Mlangi JJ, Zebedayo R, Gwasma F, Prakash T, Jafar TH, Bosworth HB, Thielman NM, Manavalan P. Hertz JT, et al. J Acquir Immune Defic Syndr. 2026 Aug 1;101(8):896-906. doi: 10.1097/QAI.0000000000003874. J Acquir Immune Defic Syndr. 2026. PMID: 42439100
BACKGROUND: In Tanzania, many people living with HIV have uncontrolled hypertension, yet integration of hypertension management into HIV care remains limited. The Community Health Worker Optimization of Antihypertensive Care in HIV (COACH) intervention was developed to int …
BACKGROUND: In Tanzania, many people living with HIV have uncontrolled hypertension, yet integration of hypertension management into HIV car …
The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.
Hicken MT, DeAngelis R, Rigby D, Burnside L, Adar S, Burgard S, Davis BA, Donnelly R, Finlay JM, Hajat A, Lee J, Perry BL, Thorpe LE, Umberson D. Hicken MT, et al. Alzheimers Dement. 2026 Jul;22(7):e71648. doi: 10.1002/alz.71648. Alzheimers Dement. 2026. PMID: 42439047 Free PMC article. Review.
The social environment refers to our interpersonal relations, workplaces, and neighborhoods, towns, or cities in which we live. ...Addressing this limitation, our paper outlines key features of the social environment and recommends priority areas of research on the …
The social environment refers to our interpersonal relations, workplaces, and neighborhoods, towns, or cities in which we live. ...Ad …
ChatGPT improves readability in validated spine patient-reported outcome measures.
Abdelmalek G, Shaikh S, Coban D, Elkholy A, Emami C, Sahai N, Hwang K, Sinha K. Abdelmalek G, et al. N Am Spine Soc J. 2026 Jun 8;27:100917. doi: 10.1016/j.xnsj.2026.100917. eCollection 2026 Sep. N Am Spine Soc J. 2026. PMID: 42438793 Free PMC article.
BACKGROUND: Spine patient-reported outcome measures (PROMs) frequently exceed recommended health literacy thresholds, limiting accessibility. Large language models (LLMs) such as ChatGPT can simplify medical text, but their effects on validated outcome instruments remain u …
BACKGROUND: Spine patient-reported outcome measures (PROMs) frequently exceed recommended health literacy thresholds, limiting access …
Application of machine learning algorithms in building health diagnostics: predictive analytics evaluating indoor air quality and sick building syndrome in educational settings.
Ismail SA, Kamar HM, Kamsah N, Lim KH, Kamaruzaman NA, Ramdan MI, Crüts B, Zaini Makhtar MM, Rafatullah M, Vashisht A. Ismail SA, et al. PeerJ. 2026 Jul 9;14:e20964. doi: 10.7717/peerj.20964. eCollection 2026. PeerJ. 2026. PMID: 42438712 Free PMC article.
The current assessment involved the use of the modified MM040NA SBS questionnaire and checklist from Indoor Air Quality (IAQ) Industry Code of Practice (IAQ-ICOP) from Department Occupational Safety and Health (DOSH), Malaysia, with participants scoring of their ans …
The current assessment involved the use of the modified MM040NA SBS questionnaire and checklist from Indoor Air Quality (IAQ) Industry Code …
Digital and computational innovations for posttraumatic stress disorder: How digital technologies can improve diagnosis, risk stratification, and individualized treatment.
Hilberdink CE, Huibregtse ME, Hinojosa CA, Dean GS, van Zuiden M, Schultebraucks K. Hilberdink CE, et al. J Trauma Stress. 2026 Jul 12. doi: 10.1002/jts.70108. Online ahead of print. J Trauma Stress. 2026. PMID: 42438276 Review.
Traditional assessments, which depend on retrospective recall and intermittent clinical contact, are limited in their ability to reflect the dynamic and context-sensitive processes that shape trauma-related mental health outcomes. Emerging digital health technologie …
Traditional assessments, which depend on retrospective recall and intermittent clinical contact, are limited in their ability to reflect the …
Nutrition and Exercise in Critical Illness (NEXIS) trial: randomized trial of combined in-bed cycling and intravenous amino acid plus usual care.
Needham DM, Files DC, Hough CL, Mayer KP, Ardren S, Fatima A, Jiang X, Day AG, Dinglas VD, Hiser SL, Kiyatkin ME, Khan A, Morris PE, Carson SS, Antkowiak M, Bakhru RN, Burns S, Nath SD, Gibbs KW, Gundel SJ, Kalema AG, Sturgill JL, Ventrone S, Heyland DK, Stapleton RD; With The NEXIS Study Team. Needham DM, et al. Am J Respir Crit Care Med. 2026 Jul 13:aamag287. doi: 10.1093/ajrccm/aamag287. Online ahead of print. Am J Respir Crit Care Med. 2026. PMID: 42438140
MEASUREMENTS AND MAIN RESULTS: In total, 115 patients (median age 55 years, 55% male, Acute Physiology and Chronic Health Evaluation II 24, >90% mechanically ventilated) were randomized (60 intervention; 55 control). ...
MEASUREMENTS AND MAIN RESULTS: In total, 115 patients (median age 55 years, 55% male, Acute Physiology and Chronic Health Evaluation …
The Effects of Incretin Mimetic Therapies on Muscle and Bone Health in Older Adults: A Narrative Review.
Saavedra JM, Chen AS, Porter Starr KN, Batsis JA. Saavedra JM, et al. Obesity (Silver Spring). 2026 Jul 12. doi: 10.1002/oby.70203. Online ahead of print. Obesity (Silver Spring). 2026. PMID: 42438123 Review.
Incretin mimetics are increasingly prescribed for the treatment of overweight and obesity, resulting not only in significant weight reduction but also co-occurring improvements in cardiovascular health and quality of life. Incretin mimetic use among older adults is expecte …
Incretin mimetics are increasingly prescribed for the treatment of overweight and obesity, resulting not only in significant weight reductio …
LEARNER: A Transfer Learning Method for Low-Rank Matrix Estimation.
McGrath S, Zhu C, O'Dea R, Guo M, Duan R. McGrath S, et al. Stat Med. 2026 Jul;45(15-17):e70669. doi: 10.1002/sim.70669. Stat Med. 2026. PMID: 42438120
Low-rank matrix estimation is a fundamental problem in statistics and machine learning with applications across biomedical sciences, including genetics, medical imaging, drug discovery, and electronic health record data analysis. In the context of heterogeneous data …
Low-rank matrix estimation is a fundamental problem in statistics and machine learning with applications across biomedical sciences, includi …
Atherosclerotic Cardiovascular Disease and Cancer.
Amend A, Horstmann H, Lavine KJ, Giannarelli C, Moore KJ. Amend A, et al. Immunol Rev. 2026 Jul;340(1):e70141. doi: 10.1111/imr.70141. Immunol Rev. 2026. PMID: 42438017 Free PMC article. Review.
Atherosclerotic cardiovascular disease (ASCVD) and cancer are increasingly recognized as interconnected diseases linked by shared immune mechanisms rather than merely overlapping risk factors. ...Together, these observations support a unified view of ASCVD and cancer …
Atherosclerotic cardiovascular disease (ASCVD) and cancer are increasingly recognized as interconnected diseases linked by shared imm …
Social network characteristics and cognitive function, decline, and mortality: A joint modeling approach.
Chen R, Posis AIB, Pederson AM, Wang J, Hirst AK, Rojas-Saunero LP, Kim YJ, Haneuse S, Peterson R, Mungas D, Torres JM, Mayeda ER, Gilsanz P, Whitmer RA, Corrada MM, Glymour MM. Chen R, et al. Alzheimers Dement. 2026 Jul;22(7):e71600. doi: 10.1002/alz.71600. Alzheimers Dement. 2026. PMID: 42437967 Free PMC article.
INTRODUCTION: Maintaining social relationships is challenging in advanced old age due to frequent changes in social networks. ...Social networks did not predict cognitive decline or mortality. DISCUSSION: Among adults aged 90+, social networks were lin …
INTRODUCTION: Maintaining social relationships is challenging in advanced old age due to frequent changes in social networks. …
Nuclear dysfunction in aging and neurodegeneration.
Aday A, Tiller J, Melukote A, Walton ZC, King A, Castillo L, Kayed R, Montalbano M. Aday A, et al. Alzheimers Dement. 2026 Jul;22(7):e71657. doi: 10.1002/alz.71657. Alzheimers Dement. 2026. PMID: 42437963 Free PMC article. Review.
Deep learning single-cell analysis for cytologic evaluation of oral potentially malignant disorders.
McRae MP, Rajsri KS, Vigneswaran N, Kerr AR, Redding SW, Thornhill MH, Murdoch C, Speight PM, Ruel N, Wolk R, Ruff RR, McDevitt JT. McRae MP, et al. Sci Rep. 2026 Jul 13;16(1):21741. doi: 10.1038/s41598-026-47538-y. Sci Rep. 2026. PMID: 42437755 Free PMC article.

The DL model produced cytology-derived parameters that correlated strongly with histopathologic diagnoses across 692 subjects with OPMDs, OSCC, and healthy controls, including declining DSE cell proportion and increasing SR cells and leukocytes with disease severity (p < 0.000

…
The DL model produced cytology-derived parameters that correlated strongly with histopathologic diagnoses across 692 subjects with OPMDs, OS …
Examining Risk Factors for Pressure Injury Development Among Nursing Home Residents: A Retrospective Study.
Brooks KR, Alderden J, Horn SD, Sharkey PD, Kennerly SM, Yap TL. Brooks KR, et al. J Clin Nurs. 2026 Jul 12. doi: 10.1111/jocn.70369. Online ahead of print. J Clin Nurs. 2026. PMID: 42437704
Clinical mobility assessments remain essential but gain value when integrated with physiological markers. As electronic health record use increases in nursing homes, future research can leverage these data to develop targeted interventions. ...
Clinical mobility assessments remain essential but gain value when integrated with physiological markers. As electronic health record …
Structure-Activity Relationship Analysis and hERG Liability Assessment of Second-Generation Antibiofilm Compounds Active Against Salmonella.
Sorge A, Bennett AN, Gregory SE, Cole AL, Woolard KJ, Nemeth AM, Crow AH, Melander RJ, Gunn JS, Melander C. Sorge A, et al. ChemMedChem. 2026 Jul 14;21(13):e70363. doi: 10.1002/cmdc.70363. ChemMedChem. 2026. PMID: 42437701 Free PMC article.
Lead antibiofilm compounds were tested for human ether-a-go-go-related gene (hERG) channel inhibition, from which we report new lead compounds with improved antibiofilm activity and reduced hERG channel inhibition....
Lead antibiofilm compounds were tested for human ether-a-go-go-related gene (hERG) channel inhibition, from which we report new lead …
Deep learning models for cell cycle phase prediction from single-cell RNA sequencing data.
Akhter H, Piktel D, Gibson LF, Hu G, Adjeroh DA. Akhter H, et al. Brief Bioinform. 2026 Jul 3;27(4):bbag342. doi: 10.1093/bib/bbag342. Brief Bioinform. 2026. PMID: 42437449 Free PMC article.
Models were trained using consensus phase labels derived from four established tools (CellCycleScore, ccAFv2, Revelio, and Tricycle) applied to single-cell gene expression datasets representing diverse biological contexts, including a human leukemia cell line (REH), periph …
Models were trained using consensus phase labels derived from four established tools (CellCycleScore, ccAFv2, Revelio, and Tricycle) applied …
Chemoradiation (CCRT) Effects on Head and Neck Muscles: Insights Into CCRT-Induced Dysphagia.
Amin MR, Gould M, Severa E, Kravietz A, Achlatis S, Tesema N, Best KA, Garber D, Strum D, Yang J, Johnson AM. Amin MR, et al. Laryngoscope. 2026 Jul 12. doi: 10.1002/lary.70722. Online ahead of print. Laryngoscope. 2026. PMID: 42437408
Rats were further split into three time points: acute (2 weeks), intermediate (5 months), and long-term (10 months), at which time tissue was harvested for analysis. Human samples included preexisting CCRT-treated and age- and sex-matched control muscle samples from head a …
Rats were further split into three time points: acute (2 weeks), intermediate (5 months), and long-term (10 months), at which time tissue wa …
Economic burden of adult mild traumatic brain injury in the United States: a scoping review of healthcare-related charges and costs.
Ran KR, Caldwell DJ, Tarapore PE, Halabi C, Aabedi AA, Velasco MCV, Saigal R, DiGiorgio AM, Huang MC, Hinson HE, Manley GT, Yue JK. Ran KR, et al. Lancet Reg Health Am. 2026 Jul 6;62:101558. doi: 10.1016/j.lana.2026.101558. eCollection 2026 Oct. Lancet Reg Health Am. 2026. PMID: 42437268 Free PMC article. Review.
We synthesized direct healthcare charges and costs associated with mTBI in the United States (U.S.). A PubMed search through October 14, 2025 identified primary studies reporting direct healthcare-related charges or costs among adults with mTBI. All estimates were s …
We synthesized direct healthcare charges and costs associated with mTBI in the United States (U.S.). A PubMed search through O …
Following Severe Pediatric Malaria, Epilepsy Screening Is Needed Even Among Children Without Coma: Findings From a Prospective Cohort Study.
Patel AA, Nishat S, Joshi RB, Mwanza S, Kasolo J, Masempela A, Musakanya T, Mwale T, Nambeye V, Nyirongo R, Tembo RG, O'Brien N, Seydel KB, Cortina C, Zhang B, Mazumdar M, Rotenberg A, Birbeck GL. Patel AA, et al. J Cent Nerv Syst Dis. 2026 Jul 10;18:11795735261467520. doi: 10.1177/11795735261467520. eCollection 2026. J Cent Nerv Syst Dis. 2026. PMID: 42436689 Free PMC article.
A novel two-hit murine model of inhaled occupational exposure-induced lung disease.
Barahona M, DeBie A, Dean LS, Klemp B, Jones K, Oyewole EO, Wahl M, Pauly M, McDermott C, Salguero FJ, Anderson GB, Henao-Tamayo M, Nordgren TM. Barahona M, et al. Physiol Rep. 2026 Jul;14(13):e71019. doi: 10.14814/phy2.71019. Physiol Rep. 2026. PMID: 42436598 Free PMC article.
Such epithelial damage and prolonged inflammation are hallmark features of various lung diseases, including chronic obstructive pulmonary disease (COPD), pulmonary fibrosis (PF), and lung cancer. Organic dust exposure (ODE), prevalent among workers in livestock and agricul …
Such epithelial damage and prolonged inflammation are hallmark features of various lung diseases, including chronic obstructive pulmonary di …
Rigorous projects and grants integrating human-centered design and implementation science: 8 tips for success.
Aung T, Osterhage KP, Graham AK, Proctor EK, Lyon AR, Munson SA. Aung T, et al. Implement Sci Commun. 2026 Jul 11. doi: 10.1186/s43058-026-01035-5. Online ahead of print. Implement Sci Commun. 2026. PMID: 42436554 Free article.
BACKGROUND: Researchers and funders increasingly see potential for integrating human-centered design (HCD) and implementation science (IS) approaches to enhance the design and uptake of health interventions and implementation strategies. ...Our considerations are in …
BACKGROUND: Researchers and funders increasingly see potential for integrating human-centered design (HCD) and implementation science …
Preliminary trial findings from Harvest Share: a cost-offset community supported agriculture model to improve diet in New York City.
LeCroy MN, Cardenas L, Chan SWC, Scherer M, Dolotina B, Lanza DV, Dowd R, Hughes M, Mei S, Barth K, Gregoire M, Rodriguez Gil AI, DeDominicis M, Acevedo M, Rodriguez A, Kourousias L, Cheng M, Wu M, Guzman J, Belli HM, Barajas-Gonzalez RG, Đoàn LN, Yi SS. LeCroy MN, et al. Int J Behav Nutr Phys Act. 2026 Jul 11. doi: 10.1186/s12966-026-01906-z. Online ahead of print. Int J Behav Nutr Phys Act. 2026. PMID: 42436486 Free article.
Mixed effect linear regression models were used to examine the impact of Harvest Share on primary (Veggie Meter score) and secondary outcomes (diet and social variables). Significant associations were based on the group (CSA vs. CC) by time (pre vs. post) interaction term. …
Mixed effect linear regression models were used to examine the impact of Harvest Share on primary (Veggie Meter score) and secondary outcome …
CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC.
McAndrews KM, Mahadevan KK, Li B, Comptdaer AM, Sockwell AM, Morse SJ, Kelly PJ, Patel SI, Kirtley ML, Moreno Diaz BA, Lyu H, Peng DH, Khazaei S, Schalck A, Zhou X, Sugimoto H, Bickert AA, Sthanam LK, Taylor MR, Kumbhar SV, Arian KA, Barekatain Y, Paradiso F, Guerrero PA, Bernard V, Sobhani N, Camacho-Acevedo AN, Bornes KE, Tran PT, Maitra A, Heffernan TP, Kalluri R. McAndrews KM, et al. EMBO J. 2026 Jul 11. doi: 10.1038/s44318-026-00854-5. Online ahead of print. EMBO J. 2026. PMID: 42436354 Free article.
Here, integrated spatial transcriptomics, single-cell RNA sequencing, and CODEX-based spatial proteomics analyses of PDAC mouse models uncover that while KRAS(G12D) inhibition by MRTX1133 initially increases CD11c(+) cells and T cell infiltration proximal to cancer cells, …
Here, integrated spatial transcriptomics, single-cell RNA sequencing, and CODEX-based spatial proteomics analyses of PDAC mouse models uncov …
Oxidative base damage to telomeres sensitizes cancer cells to ATR inhibition.
Garbouchian A, Moreno NC, Dey A, Bakkenist CJ, Opresko PL, Barnes RP. Garbouchian A, et al. Commun Biol. 2026 Jul 11. doi: 10.1038/s42003-026-10676-0. Online ahead of print. Commun Biol. 2026. PMID: 42436344 Free article.
Targeted inhibition of DNA damage response proteins has received significant clinical attention owing to the success of PARP inhibitors. Due to G1/S checkpoint inactivation, cancer cells are reliant on the G2/M checkpoint to cope with elevated DNA replication stress. ...Th …
Targeted inhibition of DNA damage response proteins has received significant clinical attention owing to the success of PARP inhibitors. Due …
AURKA regulates LGR5 in response to Helicobacter Pylori infection by modulating its deubiquitination.
Gomaa A, Maacha S, Soutto M, Giordano S, Bhat N, Kumar S, McDonald OG, El-Rifai W. Gomaa A, et al. Cell Death Differ. 2026 Jul 11. doi: 10.1038/s41418-026-01810-w. Online ahead of print. Cell Death Differ. 2026. PMID: 42436338
This study investigates the link between AURKA and LGR5 in response to H. pylori infection in gastric cancer. We analyzed publicly available datasets, gastric cancer cell lines, patient-derived organoids and xenografts (PDOs and PDXs), mouse models, and de-identifie …
This study investigates the link between AURKA and LGR5 in response to H. pylori infection in gastric cancer. We analyzed publicly av …
Immigration-Related Sociopolitical Stress, Mental Health, and Tobacco Use Among Mexican American College Students.
Schwartz SJ, Marti CN, Talavera-Garza L, North CE, Yang Q, Murthy D, Arora S, Wilkinson AV, Loukas A. Schwartz SJ, et al. J Immigr Minor Health. 2026 Jul 11. doi: 10.1007/s10903-026-01958-0. Online ahead of print. J Immigr Minor Health. 2026. PMID: 42436266
Sociopolitical stress associated with the policies and rhetoric coming from recent U.S. presidential administrations is of particular concern vis-a-vis Hispanic individuals, who have been disproportionately targeted for detention and deportation. ...Intervention and …
Sociopolitical stress associated with the policies and rhetoric coming from recent U.S. presidential administrations is of par …
Microbiome-derived queuine vitamers underlie tyrosine metabolism and predator avoidance in mosquito larvae.
Kelley M, Rathore S, Chandrasegaran K, Herbert C, Sabile CEG, Wood T, Joves J, Palacios A, Hamal B, Tompkin J, Susanto E, Uhran M, Ledezma-Ramírez A, Chen SC, Singh K, Rust R, Solorio MM, Khalid MS, Mitra AT, Vinauger C, Buschbeck EK, Limbach PA, Benoit JB. Kelley M, et al. Commun Biol. 2026 Jul 11. doi: 10.1038/s42003-026-10537-w. Online ahead of print. Commun Biol. 2026. PMID: 42436262 Free article.
Neurobiological subtypes in alcohol use disorder and their phenotypic and clinical profiles.
Brucar LR, Rawls E, Zilverstand A. Brucar LR, et al. Mol Psychiatry. 2026 Jul 11. doi: 10.1038/s41380-026-03748-4. Online ahead of print. Mol Psychiatry. 2026. PMID: 42436260
Participants with complete resting-state functional MRI (rs-fMRI), phenotypic and clinical data from the Human Connectome Project were included (N = 668; 58% Female; 22% AUD [mild AUD: n = 109; moderate-severe AUD: n = 38], 40% Female within AUD). ...
Participants with complete resting-state functional MRI (rs-fMRI), phenotypic and clinical data from the Human Connectome Project wer …
Passive early screening for Alzheimer's disease and related dementias using EHR comorbidity patterns.
Onishchenko D, Mastrianni JA, Chattopadhyay I. Onishchenko D, et al. NPJ Digit Med. 2026 Jul 11. doi: 10.1038/s41746-026-02954-2. Online ahead of print. NPJ Digit Med. 2026. PMID: 42436226 Free article.
The Zero-burden Risk Assessment (ZeBRA) is an AI-driven score that predicts incident ADRD up to a decade before diagnosis using only routine electronic health record (EHR) data, without laboratory tests, imaging, or questionnaires. Trained on 487,989 cases and 12,483,718 c …
The Zero-burden Risk Assessment (ZeBRA) is an AI-driven score that predicts incident ADRD up to a decade before diagnosis using only routine …
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