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The evolution of nanopore measurements: from biological out-of-plane pores to plastic in-plane pores.

Akabirov K, Nguyen H, Peli Thanthri S, M Barros S, Chibuike M, Park S, Soper SA. Akabirov K, et al. Lab Chip. 2026 Mar 4;26(5):1709-1738. doi: 10.1039/d5lc00885a. Lab Chip. 2026. PMID: 41603894 Free PMC article. Review.

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Insights on using plastic-based dual in-plane nanopore sensors for differentiation and shape determinations of single protein molecules.

Shivanka S, Shiri F, Chibuike M, McKinney C, Verber M, Choi J, Park S, Hall AR, Soper SA. Shivanka S, et al. Sci Rep. 2025 Apr 21;15(1):13742. doi: 10.1038/s41598-025-96232-y. Sci Rep. 2025. PMID: 40258844 Free PMC article.

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MK2 promotes p16 negative head and neck cancer migration, invasion, and metastasis.

Morgan D, Okwuone DD, Berggren KL, Arnold L, Schmidt A, Spiess C, Smith H, Yada R, Hendrikse N, Madan R, Shrock D, Lominska C, Hu M, Witek M, Soper S, Lin Y, Gao H, McCance DJ, Thomas SM, Beebe D, Kerr SC, Gan GN. Morgan D, et al. Cancer Lett. 2025 Jul 10;622:217690. doi: 10.1016/j.canlet.2025.217690. Epub 2025 Apr 2. Cancer Lett. 2025. PMID: 40185303 Free PMC article.

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Characterizing Recent PDMS Changes in Electrokinetic-Based Microfluidic Devices' Performance and Manufacturing for Cell Sorting Applications.

Hyler AR, Thomas DE, Kinskie KS, Brown KM, Duncan JL, Cemazar J, Schultz J, Brown S, Shiri F, Soper SA, Swami NS, Davalos RV. Hyler AR, et al. Electrophoresis. 2025 Aug;46(16):1185-1194. doi: 10.1002/elps.8113. Epub 2025 Feb 18. Electrophoresis. 2025. PMID: 39965072 Free PMC article.

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Extracellular volume expansion drives vertebrate axis elongation.

Michaut A, Mongera A, Gupta A, Tarazona OA, Serra M, Kefala GM, Rigoni P, Lee JG, Rivas F, Hall AR, Mahadevan L, Guevorkian K, Pourquié O. Michaut A, et al. Curr Biol. 2025 Feb 24;35(4):843-853.e6. doi: 10.1016/j.cub.2024.12.051. Epub 2025 Jan 28. Curr Biol. 2025. PMID: 39879975 Free PMC article.

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Millisecond Label-Free Single Peptide Detection and Identification Using Nanoscale Electrochromatography and Resistive Pulse Sensing.

Chibuike M, Rathnayaka C, Shivanka S, Choi J, Verber M, Park S, Soper SA. Chibuike M, et al. Anal Chem. 2025 Jan 14;97(1):427-435. doi: 10.1021/acs.analchem.4c04542. Epub 2024 Dec 23. Anal Chem. 2025. PMID: 39713813 Free PMC article.

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High-fidelity and iterative affinity extraction of hyaluronan.

Erxleben DA, Rivas F, Smith I, Poddar S, DeAngelis PL, Rahbar E, Hall AR. Erxleben DA, et al. Proteoglycan Res. 2024 Oct-Dec;2(4):e70008. doi: 10.1002/pgr2.70008. Epub 2024 Dec 6. Proteoglycan Res. 2024. PMID: 39650564 Free PMC article.

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BCMA-Directed MRD Detection as a Predictor of Relapse after BCMA CAR T in Multiple Myeloma.

Rashid A, Wesson W, Abdallah AO, Snyder J, Venkatesh P, Mushtaq MU, Shune L, Witek MA, McGuirk JP, Soper SA, Cui W, Ahmed N. Rashid A, et al. Clin Lymphoma Myeloma Leuk. 2025 Jan;25(1):52-57. doi: 10.1016/j.clml.2024.10.003. Epub 2024 Oct 11. Clin Lymphoma Myeloma Leuk. 2025. PMID: 39516088 Free PMC article.

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Microfluidic Affinity Selection of B-Lineage Cells from Peripheral Blood for Minimal Residual Disease Monitoring in Pediatric B-Type Acute Lymphoblastic Leukemia Patients.

Witek MA, Larkey NE, Bartakova A, Hupert ML, Mog S, Cronin JK, Vun J, August KJ, Soper SA. Witek MA, et al. Int J Mol Sci. 2024 Oct 2;25(19):10619. doi: 10.3390/ijms251910619. Int J Mol Sci. 2024. PMID: 39408948 Free PMC article.

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Extending Copper Interconnects and Epoxy Dielectrics to Multi-GHz Frequencies.

Park J, Xu J, Engler A, Williamson J, Mathew V, Park S, Flake J. Park J, et al. IEEE Trans Compon Packaging Manuf Technol. 2024 Jun;14(6):984-992. doi: 10.1109/tcpmt.2024.3399662. Epub 2024 May 9. IEEE Trans Compon Packaging Manuf Technol. 2024. PMID: 39309372 Free PMC article.

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Novel thermoplastic microvalves based on an elastomeric cyclic olefin copolymer.

Childers K, Freed IM, Hupert ML, Shaw B, Larsen N, Herring P, Norton JH, Shiri F, Vun J, August KJ, Witek MA, Soper SA. Childers K, et al. Lab Chip. 2024 Sep 10;24(18):4422-4439. doi: 10.1039/d4lc00501e. Lab Chip. 2024. PMID: 39171671 Free PMC article.

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A Simplified Model for the Study of Film-Boiling Droplet Motion on Microscale Ratchets.

Wang S, Ok JT, Park S, Elsharafi M, Guo Y. Wang S, et al. Appl Mech (Basel). 2024 Mar;5(1):91-101. doi: 10.3390/applmech5010006. Epub 2024 Jan 30. Appl Mech (Basel). 2024. PMID: 39170914 Free PMC article.

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Changing the Paradigm in Prognostic Breast Cancer Testing Based on Extracellular Vesicles.

Witek MA, Soper SA, Godwin AK. Witek MA, et al. Res J Biol. 2023 Jun;11(2):23-25. Epub 2023 Jun 22. Res J Biol. 2023. PMID: 38933497 Free PMC article. No abstract available.

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Engineering inlet structures to enhance DNA capture into nanochannels in a polymer nanofluidic device produced via nanoimprint lithography.

Wu J, Choi J, Uba FI, Soper SA, Park S. Wu J, et al. Micro Nano Eng. 2023 Dec;21:100230. doi: 10.1016/j.mne.2023.100230. Epub 2023 Oct 6. Micro Nano Eng. 2023. PMID: 38737190 Free PMC article.

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Detection and identification of single ribonucleotide monophosphates using a dual in-plane nanopore sensor made in a thermoplastic via replication.

Rathnayaka C, Chandrosoma IA, Choi J, Childers K, Chibuike M, Akabirov K, Shiri F, Hall AR, Lee M, McKinney C, Verber M, Park S, Soper SA. Rathnayaka C, et al. Lab Chip. 2024 May 14;24(10):2721-2735. doi: 10.1039/d3lc01062g. Lab Chip. 2024. PMID: 38656267 Free PMC article.

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Microfluidic Isolation of Neuronal-Enriched Extracellular Vesicles Shows Distinct and Common Neurological Proteins in Long COVID, HIV Infection and Alzheimer's Disease.

Pulliam L, Sun B, McCafferty E, Soper SA, Witek MA, Hu M, Ford JM, Song S, Kapogiannis D, Glesby MJ, Merenstein D, Tien PC, Freasier H, French A, McKay H, Diaz MM, Ofotokun I, Lake JE, Margolick JB, Kim EY, Levine SR, Fischl MA, Li W, Martinson J, Tang N. Pulliam L, et al. Int J Mol Sci. 2024 Mar 29;25(7):3830. doi: 10.3390/ijms25073830. Int J Mol Sci. 2024. PMID: 38612641 Free PMC article.

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Improving the Performance of Selective Solid-State Nanopore Sensing Using a Polyhistidine-Tagged Monovalent Streptavidin.

Abu Jalboush S, Wadsworth ID, Sethi K, Rogers LC, Hollis T, Hall AR. Abu Jalboush S, et al. ACS Sens. 2024 Mar 22;9(3):1602-1610. doi: 10.1021/acssensors.4c00200. Epub 2024 Mar 7. ACS Sens. 2024. PMID: 38451864 Free PMC article.

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Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State Nanopores.

Erxleben DA, Dodd RJ, Day AJ, Green DE, DeAngelis PL, Poddar S, Enghild JJ, Huebner JL, Kraus VB, Watkins AR, Reesink HL, Rahbar E, Hall AR. Erxleben DA, et al. Anal Chem. 2024 Jan 30;96(4):1606-1613. doi: 10.1021/acs.analchem.3c04387. Epub 2024 Jan 12. Anal Chem. 2024. PMID: 38215004 Free PMC article.

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Extracellular Vesicles as Liquid Biopsy Biomarkers across the Cancer Journey: From Early Detection to Recurrence.

Rayamajhi S, Sipes J, Tetlow AL, Saha S, Bansal A, Godwin AK. Rayamajhi S, et al. Clin Chem. 2024 Jan 4;70(1):206-219. doi: 10.1093/clinchem/hvad176. Clin Chem. 2024. PMID: 38175602 Free PMC article. Review.

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Nano-injection molding with resin mold inserts for prototyping of nanofluidic devices for single molecular detection.

Shiri F, Choi J, Vietz C, Rathnayaka C, Manoharan A, Shivanka S, Li G, Yu C, Murphy MC, Soper SA, Park S. Shiri F, et al. Lab Chip. 2023 Nov 7;23(22):4876-4887. doi: 10.1039/d3lc00543g. Lab Chip. 2023. PMID: 37870483 Free PMC article.

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Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan.

Babayev E, Suebthawinkul C, Gokyer D, Parkes WS, Rivas F, Pavone ME, Hall AR, Pritchard MT, Duncan FE. Babayev E, et al. Aging Cell. 2023 Nov;22(11):e14004. doi: 10.1111/acel.14004. Epub 2023 Oct 18. Aging Cell. 2023. PMID: 37850336 Free PMC article.

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Circulating Tumor Cell Subpopulations Predict Treatment Outcome in Pancreatic Ductal Adenocarcinoma (PDAC) Patients.

Freed IM, Kasi A, Fateru O, Hu M, Gonzalez P, Weatherington N, Pathak H, Hyter S, Sun W, Al-Rajabi R, Baranda J, Hupert ML, Chalise P, Godwin AK, A Witek M, Soper SA. Freed IM, et al. Cells. 2023 Sep 13;12(18):2266. doi: 10.3390/cells12182266. Cells. 2023. PMID: 37759489 Free PMC article.

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A fetal wound healing program after intrauterine bile duct injury may contribute to biliary atresia.

de Jong IEM, Hunt ML, Chen D, Du Y, Llewellyn J, Gupta K, Li D, Erxleben D, Rivas F, Hall AR, Furth EE, Naji A, Liu C, Dhand A, Burdick JA, Davey MG, Flake AW, Porte RJ, Russo PA, Gaynor JW, Wells RG. de Jong IEM, et al. J Hepatol. 2023 Dec;79(6):1396-1407. doi: 10.1016/j.jhep.2023.08.010. Epub 2023 Aug 21. J Hepatol. 2023. PMID: 37611641 Free PMC article.

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In-plane Extended Nano-coulter Counter (XnCC) for the Label-free Electrical Detection of Biological Particles.

Zhao Z, Vaidyanathan S, Bhanja P, Gamage S, Saha S, McKinney C, Choi J, Park S, Pahattuge T, Wijerathne H, Jackson JM, Huppert ML, Witek MA, Soper SA. Zhao Z, et al. Electroanalysis. 2022 Dec;34(12):1961-1975. doi: 10.1002/elan.202200091. Epub 2022 Jun 14. Electroanalysis. 2022. PMID: 37539083 Free PMC article.

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High Sensitivity Extended Nano-Coulter Counter for Detection of Viral Particles and Extracellular Vesicles.

Vaidyanathan S, Wijerathne H, Gamage SST, Shiri F, Zhao Z, Choi J, Park S, Witek MA, McKinney C, Verber M, Hall AR, Childers K, McNickle T, Mog S, Yeh E, Godwin AK, Soper SA. Vaidyanathan S, et al. Anal Chem. 2023 Jul 4;95(26):9892-9900. doi: 10.1021/acs.analchem.3c00855. Epub 2023 Jun 19. Anal Chem. 2023. PMID: 37336762 Free PMC article.

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Assessing Breast Cancer Molecular Subtypes Using Extracellular Vesicles' mRNA.

Hu M, Brown V, Jackson JM, Wijerathne H, Pathak H, Koestler DC, Nissen E, Hupert ML, Muller R, Godwin AK, Witek MA, Soper SA. Hu M, et al. Anal Chem. 2023 May 16;95(19):7665-7675. doi: 10.1021/acs.analchem.3c00624. Epub 2023 Apr 18. Anal Chem. 2023. PMID: 37071799 Free PMC article.

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A Simple Micromilled Microfluidic Impedance Cytometer with Vertical Parallel Electrodes for Cell Viability Analysis.

Eades J, Audiffred JF, Fincher M, Choi JW, Soper SA, Monroe WT. Eades J, et al. Micromachines (Basel). 2023 Jan 22;14(2):283. doi: 10.3390/mi14020283. Micromachines (Basel). 2023. PMID: 36837983 Free PMC article.

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Modifying surface charge density of thermoplastic nanofluidic biosensors by multivalent cations within the slip plane of the electric double layer.

Jia Z, Choi J, Lee S, Soper SA, Park S. Jia Z, et al. Colloids Surf A Physicochem Eng Asp. 2022 Sep 5;648:129147. doi: 10.1016/j.colsurfa.2022.129147. Epub 2022 May 4. Colloids Surf A Physicochem Eng Asp. 2022. PMID: 36685784 Free PMC article.

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Nanofluidic devices for the separation of biomolecules.

Rathnayaka C, Amarasekara CA, Akabirov K, Murphy MC, Park S, Witek MA, Soper SA. Rathnayaka C, et al. J Chromatogr A. 2022 Nov 8;1683:463539. doi: 10.1016/j.chroma.2022.463539. Epub 2022 Sep 30. J Chromatogr A. 2022. PMID: 36223665 Free PMC article. Review.

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Microfluidic affinity selection of active SARS-CoV-2 virus particles.

Gamage SST, Pahattuge TN, Wijerathne H, Childers K, Vaidyanathan S, Athapattu US, Zhang L, Zhao Z, Hupert ML, Muller RM, Muller-Cohn J, Dickerson J, Dufek D, Geisbrecht BV, Pathak H, Pessetto Z, Gan GN, Choi J, Park S, Godwin AK, Witek MA, Soper SA. Gamage SST, et al. Sci Adv. 2022 Sep 30;8(39):eabn9665. doi: 10.1126/sciadv.abn9665. Epub 2022 Sep 28. Sci Adv. 2022. PMID: 36170362 Free PMC article.

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Fluidic operation of a polymer-based nanosensor chip for analysing single molecules.

Vaidyanathan S, Gamage S, Dathathreya K, Kryk R, Manoharan A, Zhao Z, Zhang L, Choi J, Park D, Park S, Soper SA. Vaidyanathan S, et al. Flow (Camb). 2022;2:E14. doi: 10.1017/flo.2022.8. Epub 2022 Jun 27. Flow (Camb). 2022. PMID: 35936867 Free PMC article.

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Air bubble removal: Wettability contrast enabled microfluidic interconnects.

Zhao X, Ma C, Park DS, Soper SA, Murphy MC. Zhao X, et al. Sens Actuators B Chem. 2022 Jun 15;361:131687. doi: 10.1016/j.snb.2022.131687. Epub 2022 Mar 12. Sens Actuators B Chem. 2022. PMID: 35611132 Free PMC article.

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Optimizing the sensitivity and resolution of hyaluronan analysis with solid-state nanopores.

Rivas F, DeAngelis PL, Rahbar E, Hall AR. Rivas F, et al. Sci Rep. 2022 Mar 16;12(1):4469. doi: 10.1038/s41598-022-08533-1. Sci Rep. 2022. PMID: 35296752 Free PMC article.

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A High-adhesion Binding Strategy for Silica Nanoparticle-based Superhydrophobic Coatings.

Zhao X, Murphy MC. Zhao X, et al. Colloids Surf A Physicochem Eng Asp. 2021 Sep 20;625:126810. doi: 10.1016/j.colsurfa.2021.126810. Epub 2021 May 11. Colloids Surf A Physicochem Eng Asp. 2021. PMID: 35221533 Free PMC article.

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Methods for isolating and analyzing physiological hyaluronan: a review.

Rivas F, Erxleben D, Smith I, Rahbar E, DeAngelis PL, Cowman MK, Hall AR. Rivas F, et al. Am J Physiol Cell Physiol. 2022 Apr 1;322(4):C674-C687. doi: 10.1152/ajpcell.00019.2022. Epub 2022 Feb 23. Am J Physiol Cell Physiol. 2022. PMID: 35196167 Free PMC article. Review.

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Label-Free Identification of Single Mononucleotides by Nanoscale Electrophoresis.

Choi J, Jia Z, Riahipour R, McKinney CJ, Amarasekara CA, Weerakoon-Ratnayake KM, Soper SA, Park S. Choi J, et al. Small. 2021 Oct;17(42):e2102567. doi: 10.1002/smll.202102567. Epub 2021 Sep 23. Small. 2021. PMID: 34558175 Free PMC article.

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Isolation and analysis methods of extracellular vesicles (EVs).

Zhao Z, Wijerathne H, Godwin AK, Soper SA. Zhao Z, et al. Extracell Vesicles Circ Nucl Acids. 2021;2:80-103. doi: 10.20517/evcna.2021.07. Epub 2020 Mar 30. Extracell Vesicles Circ Nucl Acids. 2021. PMID: 34414401 Free PMC article.

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Tailoring Thermoplastic In-Plane Nanopore Size by Thermal Fusion Bonding for the Analysis of Single Molecules.

Athapattu US, Rathnayaka C, Vaidyanathan S, Gamage SST, Choi J, Riahipour R, Manoharan A, Hall AR, Park S, Soper SA. Athapattu US, et al. ACS Sens. 2021 Aug 27;6(8):3133-3143. doi: 10.1021/acssensors.1c01359. Epub 2021 Aug 18. ACS Sens. 2021. PMID: 34406743 Free PMC article.

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Analytical Technologies for Liquid Biopsy of Subcellular Materials.

Campos CDM, Childers K, Gamage SST, Wijerathne H, Zhao Z, Soper SA. Campos CDM, et al. Annu Rev Anal Chem (Palo Alto Calif). 2021 Jul 27;14(1):207-229. doi: 10.1146/annurev-anchem-091520-093931. Annu Rev Anal Chem (Palo Alto Calif). 2021. PMID: 33974805 Free PMC article.

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System Modularity Chip for Analysis of Rare Targets (SMART-Chip): Liquid Biopsy Samples.

Pahattuge TN, Freed IM, Hupert ML, Vaidyanathan S, Childers K, Witek MA, Weerakoon-Ratnayake K, Park D, Kasi A, Al-Kasspooles MF, Murphy MC, Soper SA. Pahattuge TN, et al. ACS Sens. 2021 May 28;6(5):1831-1839. doi: 10.1021/acssensors.0c02728. Epub 2021 May 3. ACS Sens. 2021. PMID: 33938745 Free PMC article.

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Microfluidic gasketless interconnects sealed by superhydrophobic surfaces.

Zhao X, Park DS, Soper SA, Murphy MC. Zhao X, et al. J Microelectromech Syst. 2020 Oct;29(5):894-899. doi: 10.1109/jmems.2020.3000325. Epub 2020 Jun 12. J Microelectromech Syst. 2020. PMID: 33746475 Free PMC article.

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Thermoplastic nanofluidic devices for identifying abasic sites in single DNA molecules.

Vaidyanathan S, Weerakoon-Ratnayake KM, Uba FI, Hu B, Kaufman D, Choi J, Park S, Soper SA. Vaidyanathan S, et al. Lab Chip. 2021 Apr 20;21(8):1579-1589. doi: 10.1039/d0lc01038c. Lab Chip. 2021. PMID: 33651049 Free PMC article.

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Solid-phase XRN1 reactions for RNA cleavage: application in single-molecule sequencing.

Athapattu US, Amarasekara CA, Immel JR, Bloom S, Barany F, Nagel AC, Soper SA. Athapattu US, et al. Nucleic Acids Res. 2021 Apr 19;49(7):e41. doi: 10.1093/nar/gkab001. Nucleic Acids Res. 2021. PMID: 33511416 Free PMC article.

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Electrokinetic identification of ribonucleotide monophosphates (rNMPs) using thermoplastic nanochannels.

Amarasekara CA, Rathnayaka C, Athapattu US, Zhang L, Choi J, Park S, Nagel AC, Soper SA. Amarasekara CA, et al. J Chromatogr A. 2021 Feb 8;1638:461892. doi: 10.1016/j.chroma.2021.461892. Epub 2021 Jan 8. J Chromatogr A. 2021. PMID: 33477027 Free PMC article.

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Open-tubular nanoelectrochromatography (OT-NEC): gel-free separation of single stranded DNAs (ssDNAs) in thermoplastic nanochannels.

Amarasekara CA, Athapattu US, Rathnayaka C, Choi J, Park S, Soper SA. Amarasekara CA, et al. Electrophoresis. 2020 Oct;41(18-19):1627-1640. doi: 10.1002/elps.202000109. Epub 2020 Aug 7. Electrophoresis. 2020. PMID: 33460211 Free PMC article.

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Flexible-templated imprinting for fluorine-free, omniphobic plastics with re-entrant structures.

Zhao X, Park DS, Choi J, Park S, Soper SA, Murphy MC. Zhao X, et al. J Colloid Interface Sci. 2021 Mar;585:668-675. doi: 10.1016/j.jcis.2020.10.046. Epub 2020 Oct 20. J Colloid Interface Sci. 2021. PMID: 33127056 Free PMC article.

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Affinity enrichment of extracellular vesicles from plasma reveals mRNA changes associated with acute ischemic stroke.

Wijerathne H, Witek MA, Jackson JM, Brown V, Hupert ML, Herrera K, Kramer C, Davidow AE, Li Y, Baird AE, Murphy MC, Soper SA. Wijerathne H, et al. Commun Biol. 2020 Oct 26;3(1):613. doi: 10.1038/s42003-020-01336-y. Commun Biol. 2020. PMID: 33106557 Free PMC article.

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An integrated, optofluidic system with aligned optical waveguides, microlenses, and coupling prisms for fluorescence sensing.

Park DS, Young BM, You BH, Singh V, Soper SA, Murphy MC. Park DS, et al. J Microelectromech Syst. 2020 Aug;29(4):600-609. doi: 10.1109/jmems.2020.3004374. Epub 2020 Jul 2. J Microelectromech Syst. 2020. PMID: 39391841 Free PMC article.

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Liquid biopsy markers for stroke diagnosis.

Wijerathne H, Witek MA, Baird AE, Soper SA. Wijerathne H, et al. Expert Rev Mol Diagn. 2020 Aug;20(8):771-788. doi: 10.1080/14737159.2020.1777859. Epub 2020 Jul 5. Expert Rev Mol Diagn. 2020. PMID: 32500751 Free PMC article. Review.

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Application of Multiplex Bisulfite PCR-Ligase Detection Reaction-Real-Time Quantitative PCR Assay in Interrogating Bioinformatically Identified, Blood-Based Methylation Markers for Colorectal Cancer.

Bacolod MD, Mirza AH, Huang J, Giardina SF, Feinberg PB, Soper SA, Barany F. Bacolod MD, et al. J Mol Diagn. 2020 Jul;22(7):885-900. doi: 10.1016/j.jmoldx.2020.03.009. Epub 2020 May 12. J Mol Diagn. 2020. PMID: 32407802 Free PMC article.

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Robust, transparent, superhydrophobic coatings using novel hydrophobic/hydrophilic dual-sized silica particles.

Zhao X, Park DS, Choi J, Park S, Soper SA, Murphy MC. Zhao X, et al. J Colloid Interface Sci. 2020 Aug 15;574:347-354. doi: 10.1016/j.jcis.2020.04.065. Epub 2020 Apr 18. J Colloid Interface Sci. 2020. PMID: 32335484 Free PMC article.

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Randomized Phase IIB Trial of the Lignan Secoisolariciresinol Diglucoside in Premenopausal Women at Increased Risk for Development of Breast Cancer.

Fabian CJ, Khan SA, Garber JE, Dooley WC, Yee LD, Klemp JR, Nydegger JL, Powers KR, Kreutzjans AL, Zalles CM, Metheny T, Phillips TA, Hu J, Koestler DC, Chalise P, Yellapu NK, Jernigan C, Petroff BK, Hursting SD, Kimler BF. Fabian CJ, et al. Cancer Prev Res (Phila). 2020 Jul;13(7):623-634. doi: 10.1158/1940-6207.CAPR-20-0050. Epub 2020 Apr 20. Cancer Prev Res (Phila). 2020. PMID: 32312713 Free PMC article. Clinical Trial.

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Understanding of plasticity size-effect governed mechanical response and incomplete die filling in a microscale double-punch molding configuration.

Zhang B, Dodaran MS, Shao S, Choi J, Park S, Meng WJ. Zhang B, et al. Int J Mech Sci. 2020 Apr 15;172:105406. doi: 10.1016/j.ijmecsci.2019.105406. Epub 2019 Dec 23. Int J Mech Sci. 2020. PMID: 34140747 Free PMC article.

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Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment.

Pahattuge TN , Jackson JM , Digamber R , Wijerathne H , Brown V , Witek MA , Perera C , Givens RS , Peterson BR , Soper SA . Pahattuge TN , et al. Chem Commun (Camb). 2020 Apr 14;56(29):4098-4101. doi: 10.1039/c9cc09598e. Epub 2020 Mar 12. Chem Commun (Camb). 2020. PMID: 32163053 Free PMC article.

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Microfluidic Device for On-Chip Immunophenotyping and Cytogenetic Analysis of Rare Biological Cells.

M Weerakoon-Ratnayake K, Vaidyanathan S, Larky N, Dathathreya K, Hu M, Jose J, Mog S, August K, K Godwin A, L Hupert M, A Witek M, A Soper S. M Weerakoon-Ratnayake K, et al. Cells. 2020 Feb 24;9(2):519. doi: 10.3390/cells9020519. Cells. 2020. PMID: 32102446 Free PMC article.

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Prediction of blood-based biomarkers and subsequent design of bisulfite PCR-LDR-qPCR assay for breast cancer detection.

Bacolod MD, Huang J, Giardina SF, Feinberg PB, Mirza AH, Swistel A, Soper SA, Barany F. Bacolod MD, et al. BMC Cancer. 2020 Jan 31;20(1):85. doi: 10.1186/s12885-020-6574-4. BMC Cancer. 2020. PMID: 32005108 Free PMC article.

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The need for rapid therapeutic efficacy testing for cancer therapy.

Kaufman DG. Kaufman DG. Exp Mol Pathol. 2020 Apr;113:104382. doi: 10.1016/j.yexmp.2020.104382. Epub 2020 Jan 23. Exp Mol Pathol. 2020. PMID: 31982397 Free PMC article. No abstract available.

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Single-molecule detection of cancer mutations using a novel PCR-LDR-qPCR assay.

Ruiz C, Huang J, Giardina SF, Feinberg PB, Mirza AH, Bacolod MD, Soper SA, Barany F. Ruiz C, et al. Hum Mutat. 2020 May;41(5):1051-1068. doi: 10.1002/humu.23987. Epub 2020 Feb 17. Hum Mutat. 2020. PMID: 31950578 Free PMC article.

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Label-free counting of affinity-enriched circulating tumor cells (CTCs) using a thermoplastic micro-Coulter counter (μCC).

Kong C, Hu M, Weerakoon-Ratnayake KM, Witek MA, Dathathreya K, Hupert ML, Soper SA. Kong C, et al. Analyst. 2020 Mar 2;145(5):1677-1686. doi: 10.1039/c9an01802f. Analyst. 2020. PMID: 31867587 Free PMC article.

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60

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Cell Separations and Sorting.

Witek MA, Freed IM, Soper SA. Witek MA, et al. Anal Chem. 2020 Jan 7;92(1):105-131. doi: 10.1021/acs.analchem.9b05357. Epub 2019 Dec 20. Anal Chem. 2020. PMID: 31808677 Free PMC article. Review. No abstract available.

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Can CpG methylation serve as surrogate markers for immune infiltration in cancer?

Bacolod MD, Barany F, Fisher PB. Bacolod MD, et al. Adv Cancer Res. 2019;143:351-384. doi: 10.1016/bs.acr.2019.03.007. Epub 2019 Apr 17. Adv Cancer Res. 2019. PMID: 31202362 Review.

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Scalable fabrication of sub-10 nm polymer nanopores for DNA analysis.

Choi J, Lee CC, Park S. Choi J, et al. Microsyst Nanoeng. 2019 Apr 8;5:12. doi: 10.1038/s41378-019-0050-9. eCollection 2019. Microsyst Nanoeng. 2019. PMID: 31057939 Free PMC article.

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Fabrication of polymeric dual-scale nanoimprint molds using a polymer stencil membrane.

Choi J, Jia Z, Park S. Choi J, et al. Microelectron Eng. 2018 Nov 5;199:101-105. doi: 10.1016/j.mee.2018.07.009. Epub 2018 Jul 19. Microelectron Eng. 2018. PMID: 31011235 Free PMC article.

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64

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Time-Delayed Integration-Spectral Flow Cytometer (TDI-SFC) for Low-Abundance-Cell Immunophenotyping.

Hu W, Soper SA, Jackson JM. Hu W, et al. Anal Chem. 2019 Apr 2;91(7):4656-4664. doi: 10.1021/acs.analchem.9b00021. Epub 2019 Mar 13. Anal Chem. 2019. PMID: 30817129 Free PMC article.

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Nanohole array plasmonic biosensors: Emerging point-of-care applications.

Prasad A, Choi J, Jia Z, Park S, Gartia MR. Prasad A, et al. Biosens Bioelectron. 2019 Apr 1;130:185-203. doi: 10.1016/j.bios.2019.01.037. Epub 2019 Jan 24. Biosens Bioelectron. 2019. PMID: 30738247 Free PMC article. Review.

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66

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Microfluidic-based solid phase extraction of cell free DNA.

Campos CDM, Gamage SST, Jackson JM, Witek MA, Park DS, Murphy MC, Godwin AK, Soper SA. Campos CDM, et al. Lab Chip. 2018 Nov 6;18(22):3459-3470. doi: 10.1039/c8lc00716k. Lab Chip. 2018. PMID: 30339164 Free PMC article.

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Droplet Impinging Behavior on Surfaces with Wettability Contrasts.

Farshchian B, Pierce J, Beheshti MS, Park S, Kim N. Farshchian B, et al. Microelectron Eng. 2018 Aug 5;195:50-56. doi: 10.1016/j.mee.2018.03.019. Epub 2018 Mar 20. Microelectron Eng. 2018. PMID: 30270957 Free PMC article.

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68

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Patterned electromagnetic alignment of magnetic nanowires.

Beheshti M, Choi J, Geng X, Podlaha-Murphy E, Park S. Beheshti M, et al. Microelectron Eng. 2018 Jun 5;193:71-78. doi: 10.1016/j.mee.2018.02.021. Epub 2018 Feb 21. Microelectron Eng. 2018. PMID: 30270956 Free PMC article.

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69

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Selection of UV-resins for nanostructured molds for thermal-NIL.

Jia Z, Choi J, Park S. Jia Z, et al. Nanotechnology. 2018 Sep 7;29(36):365302. doi: 10.1088/1361-6528/aacd33. Epub 2018 Jun 18. Nanotechnology. 2018. PMID: 29911991 Free PMC article.

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Electrokinetic transport properties of deoxynucleotide monophosphates (dNMPs) through thermoplastic nanochannels.

O'Neil C, Amarasekara CA, Weerakoon-Ratnayake KM, Gross B, Jia Z, Singh V, Park S, Soper SA. O'Neil C, et al. Anal Chim Acta. 2018 Oct 16;1027:67-75. doi: 10.1016/j.aca.2018.04.047. Epub 2018 Apr 21. Anal Chim Acta. 2018. PMID: 29866271 Free PMC article.

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71

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Molecular Profiling of Liquid Biopsy Samples for Precision Medicine.

Campos CDM, Jackson JM, Witek MA, Soper SA. Campos CDM, et al. Cancer J. 2018 Mar/Apr;24(2):93-103. doi: 10.1097/PPO.0000000000000311. Cancer J. 2018. PMID: 29601336 Free PMC article. Review.

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72

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Accurate, predictable, repeatable micro-assembly technology for polymer, microfluidic modules.

Lee TY, Han K, Barrett DO, Park S, Soper SA, Murphy MC. Lee TY, et al. Sens Actuators B Chem. 2018 Jan;254:1249-1258. doi: 10.1016/j.snb.2017.07.189. Epub 2017 Aug 2. Sens Actuators B Chem. 2018. PMID: 29531428 Free PMC article.

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Isolation of circulating plasma cells from blood of patients diagnosed with clonal plasma cell disorders using cell selection microfluidics.

Kamande JW, Lindell MAM, Witek MA, Voorhees PM, Soper SA. Kamande JW, et al. Integr Biol (Camb). 2018 Feb 19;10(2):82-91. doi: 10.1039/c7ib00183e. Integr Biol (Camb). 2018. PMID: 29372735 Free PMC article.

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Staphylococcus aureus extracellular vesicles (EVs): surface-binding antagonists of biofilm formation.

Im H, Lee S, Soper SA, Mitchell RJ. Im H, et al. Mol Biosyst. 2017 Nov 21;13(12):2704-2714. doi: 10.1039/c7mb00365j. Mol Biosyst. 2017. PMID: 29104975 Free PMC article.

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Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells.

Jackson JM, Witek MA, Kamande JW, Soper SA. Jackson JM, et al. Chem Soc Rev. 2017 Jul 17;46(14):4245-4280. doi: 10.1039/c7cs00016b. Chem Soc Rev. 2017. PMID: 28632258 Free PMC article. Review.

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3D nanomolding and fluid mixing in micromixers with micro-patterned microchannel walls.

Farshchian B, Amirsadeghi A, Choi J, Park DS, Kim N, Park S. Farshchian B, et al. Nano Converg. 2017;4(1):4. doi: 10.1186/s40580-017-0098-x. Epub 2017 Mar 1. Nano Converg. 2017. PMID: 28303213 Free PMC article.

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Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule.

Witek MA, Aufforth RD, Wang H, Kamande JW, Jackson JM, Pullagurla SR, Hupert ML, Usary J, Wysham WZ, Hilliard D, Montgomery S, Bae-Jump V, Carey LA, Gehrig PA, Milowsky MI, Perou CM, Soper JT, Whang YE, Yeh JJ, Martin G, Soper SA. Witek MA, et al. NPJ Precis Oncol. 2017;1:24. doi: 10.1038/s41698-017-0028-8. Epub 2017 Jul 25. NPJ Precis Oncol. 2017. PMID: 29657983 Free PMC article.

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Thermoplastic nanofluidic devices for biomedical applications.

Weerakoon-Ratnayake KM, O'Neil CE, Uba FI, Soper SA. Weerakoon-Ratnayake KM, et al. Lab Chip. 2017 Jan 31;17(3):362-381. doi: 10.1039/c6lc01173j. Lab Chip. 2017. PMID: 28009883 Free PMC article. Review.

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Characterization of activated cyclic olefin copolymer: effects of ethylene/norbornene content on the physiochemical properties.

O'Neil CE, Taylor S, Ratnayake K, Pullagurla S, Singh V, Soper SA. O'Neil CE, et al. Analyst. 2016 Nov 28;141(24):6521-6532. doi: 10.1039/c6an01448h. Analyst. 2016. PMID: 27827488 Free PMC article.

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Effect of Different Fluids on Rectified Motion of Leidenfrost Droplets on Micro/Sub-Micron Ratchets.

Ok JT, Choi J, Brown E, Park S. Ok JT, et al. Microelectron Eng. 2016 Jun 1;158:130-134. doi: 10.1016/j.mee.2016.04.018. Epub 2016 Apr 24. Microelectron Eng. 2016. PMID: 27721527 Free PMC article.

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Electrophoretic Separation of Single Particles Using Nanoscale Thermoplastic Columns.

Weerakoon-Ratnayake KM, Uba FI, Oliver-Calixte NJ, Soper SA. Weerakoon-Ratnayake KM, et al. Anal Chem. 2016 Apr 5;88(7):3569-77. doi: 10.1021/acs.analchem.5b04065. Epub 2016 Mar 22. Anal Chem. 2016. PMID: 26963496 Free PMC article.

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82

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Interrogating Surface Functional Group Heterogeneity of Activated Thermoplastics Using Super-Resolution Fluorescence Microscopy.

ONeil CE, Jackson JM, Shim SH, Soper SA. ONeil CE, et al. Anal Chem. 2016 Apr 5;88(7):3686-96. doi: 10.1021/acs.analchem.5b04472. Epub 2016 Mar 11. Anal Chem. 2016. PMID: 26927303 Free PMC article.

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Cancer: a global concern that demands new detection technologies.

Soper SA, Rasooly A. Soper SA, et al. Analyst. 2016 Jan 21;141(2):367-70. doi: 10.1039/c5an90101d. Analyst. 2016. PMID: 26688866 Free PMC article. No abstract available.

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Microfluidics for the detection of minimal residual disease in acute myeloid leukemia patients using circulating leukemic cells selected from blood.

Jackson JM, Taylor JB, Witek MA, Hunsucker SA, Waugh JP, Fedoriw Y, Shea TC, Soper SA, Armistead PM. Jackson JM, et al. Analyst. 2016 Jan 21;141(2):640-51. doi: 10.1039/c5an01836f. Analyst. 2016. PMID: 26523411 Free PMC article.

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85

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Enzymatic cleavage of uracil-containing single-stranded DNA linkers for the efficient release of affinity-selected circulating tumor cells.

Nair SV, Witek MA, Jackson JM, Lindell MA, Hunsucker SA, Sapp T, Perry CE, Hupert ML, Bae-Jump V, Gehrig PA, Wysham WZ, Armistead PM, Voorhees P, Soper SA. Nair SV, et al. Chem Commun (Camb). 2015 Feb 21;51(15):3266-9. doi: 10.1039/c4cc09765c. Chem Commun (Camb). 2015. PMID: 25616078 Free PMC article.

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High process yield rates of thermoplastic nanofluidic devices using a hybrid thermal assembly technique.

Uba FI, Hu B, Weerakoon-Ratnayake K, Oliver-Calixte N, Soper SA. Uba FI, et al. Lab Chip. 2015 Feb 21;15(4):1038-49. doi: 10.1039/c4lc01254b. Lab Chip. 2015. PMID: 25511610 Free PMC article.

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