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Maternal low-sodium diet impairs hippocampal neurogenesis and cognition in adult mouse offspring.

Ke X, Grobe CC, Grobe JL, Yu W, Reho JJ, Varberg KM, Lane RH, Segar JL. Ke X, et al. Am J Physiol Regul Integr Comp Physiol. 2026 May 1;330(5):R463-R477. doi: 10.1152/ajpregu.00304.2025. Epub 2026 Mar 28. Am J Physiol Regul Integr Comp Physiol. 2026. PMID: 41902531 Free PMC article.

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Localization and quantification of placental HDAC9 and RGS2 during preeclampsia.

Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Sigmund CD, Kwitek AE, Grobe JL, McIntosh JJ. Opichka MA, et al. Physiol Genomics. 2025 Nov 1;57(11):629-637. doi: 10.1152/physiolgenomics.00156.2024. Epub 2025 Sep 22. Physiol Genomics. 2025. PMID: 40983484 Free PMC article.

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Time-Restricted Feeding Attenuates Salt-Sensitive Hypertension and Renal Damage.

Yunker L, Usa K, Williams AC, Reho JJ, Grobe JL, Gumz ML, Kriegel AJ. Yunker L, et al. Hypertension. 2025 Oct;82(10):1743-1753. doi: 10.1161/HYPERTENSIONAHA.125.24857. Epub 2025 Aug 6. Hypertension. 2025. PMID: 40765526 Free PMC article.

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Gut microbial contributions to thermogenesis.

Kazen A, Grobe JL, Kirby JR. Kazen A, et al. J Exp Biol. 2025 Jul 15;228(14):jeb249791. doi: 10.1242/jeb.249791. Epub 2025 Jul 11. J Exp Biol. 2025. PMID: 40642960 Review.

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Cullin-3 regulates the renal baroreceptor machinery that controls renin gene expression.

Golosova D, Kumar G, Lu KT, Muskus Veitia PC, Hantke Guixa A, Wackman KK, Fekete EM, Brozoski DT, Grobe JL, Sequeira-Lopez MLS, Gomez RA, Nakagawa P, Sigmund CD. Golosova D, et al. JCI Insight. 2025 Jul 8;10(15):e194075. doi: 10.1172/jci.insight.194075. eCollection 2025 Aug 8. JCI Insight. 2025. PMID: 40627460 Free PMC article.

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Angiotensin AT₁R expressing cells within the ventral hypothalamus modulate integrative control of cardiometabolic functions.

Pasos J, Wagner VA, Lawton SBR, Madison AM, Nandani K, Mathieu NM, Grobe CC, Reho JJ, Freudinger BP, Sherman AJ, Brozoski DT, Morselli LL, Burnett CML, Segar JL, Nakagawa P, Sigmund CD, Grobe JL. Pasos J, et al. iScience. 2025 May 30;28(7):112797. doi: 10.1016/j.isci.2025.112797. eCollection 2025 Jul 18. iScience. 2025. PMID: 40585361 Free PMC article.

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Role of the Renin-Angiotensin System in Blood Pressure Regulation in Smooth Muscle-Specific Cullin-3 Deficient Mice.

Golosova D, Kumar G, Chaihongsa N, Reho JJ, Lu KT, Brozoski DT, Wackman KK, Lawton SBR, Muskus PC, Lin BL, Grobe JL, Nakagawa P, Sigmund CD. Golosova D, et al. Hypertension. 2025 Jul;82(7):1208-1220. doi: 10.1161/HYPERTENSIONAHA.125.25045. Epub 2025 May 14. Hypertension. 2025. PMID: 40440505 Free article.

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Reutericyclin mitigates risperidone-induced suppression of anaerobic energy expenditure.

Hadiono MA, Kazen AB, Aboulalazm FA, Burnett CML, Reho JJ, Kindel TL, Grobe JL, Kirby JR. Hadiono MA, et al. Am J Physiol Regul Integr Comp Physiol. 2025 Jun 1;328(6):R741-R757. doi: 10.1152/ajpregu.00190.2024. Epub 2025 Apr 15. Am J Physiol Regul Integr Comp Physiol. 2025. PMID: 40235074 Free PMC article.

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Reutericyclin, a specialized metabolite of Limosilactobacillus reuteri, mitigates risperidone-induced weight gain in mice.

Aboulalazm FA, Kazen AB, deLeon O, Müller S, Saravia FL, Lozada-Fernandez V, Hadiono MA, Keyes RF, Smith BC, Kellogg SL, Grobe JL, Kindel TL, Kirby JR. Aboulalazm FA, et al. Gut Microbes. 2025 Dec;17(1):2477819. doi: 10.1080/19490976.2025.2477819. Epub 2025 Apr 7. Gut Microbes. 2025. PMID: 40190120 Free PMC article.

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Definitive Evidence for the Identification and Function of Renin-Expressing Cholinergic Neurons in the Nucleus Ambiguus.

Fekete ÉM, Gomez J, Ghobrial M, Kaminski K, Muskus PC, Boychuk CR, Hantke Guixa A, Vazirabad I, Xie M, Ganiyu A, Golosova D, Mathieu NM, Wang YB, Lu KT, Wackman KK, Brozoski DT, Mouradian GC, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P. Fekete ÉM, et al. Hypertension. 2025 Feb;82(2):282-292. doi: 10.1161/HYPERTENSIONAHA.124.23740. Epub 2024 Dec 2. Hypertension. 2025. PMID: 39618396 Free PMC article.

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Early-life sodium restriction programs autonomic dysfunction and salt sensitivity in male C57BL/6J mice.

Ziegler AA, Lawton SBR, Fekete EM, Brozoski DT, Wagner VA, Grobe CC, Sigmund CD, Nakagawa P, Grobe JL, Segar JL. Ziegler AA, et al. Am J Physiol Regul Integr Comp Physiol. 2025 Jan 1;328(1):R109-R120. doi: 10.1152/ajpregu.00250.2024. Epub 2024 Nov 16. Am J Physiol Regul Integr Comp Physiol. 2025. PMID: 39548798 Free PMC article.

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Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence.

Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL. Lawton SBR, et al. Hypertension. 2024 Nov;81(11):2209-2217. doi: 10.1161/HYPERTENSIONAHA.124.20524. Epub 2024 Sep 24. Hypertension. 2024. PMID: 39315447 Free PMC article. Review.

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Long-term Metabolic Dysfunction Programming in Female Mice by Serial Moderate Restriction of a High-fat High-sucrose Diet.

Wildes MP, Fernando DG, Grobe CC, Reho JJ, Grobe JL, Kidambi S, Kindel TL, Kwitek AE, Segar JL, Williams JS, Morselli LL. Wildes MP, et al. Endocrinology. 2024 Aug 27;165(10):bqae117. doi: 10.1210/endocr/bqae117. Endocrinology. 2024. PMID: 39236000 Free PMC article.

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Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure.

Mathieu NM, Tan EE, Reho JJ, Brozoski DT, Muskus PC, Lu KT, Wackman KK, Grobe JL, Nakagawa P, Sigmund CD. Mathieu NM, et al. Hypertension. 2024 Jun;81(6):1332-1344. doi: 10.1161/HYPERTENSIONAHA.124.22874. Epub 2024 Apr 17. Hypertension. 2024. PMID: 38629290 Free PMC article.

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Diet in Food Insecurity: A Mediator of Metabolic Health?

Morselli LL, Amjad R, James R, Kindel TL, Kwitek AE, Williams JS, Grobe JL, Kidambi S. Morselli LL, et al. J Endocr Soc. 2024 Apr 2;8(6):bvae062. doi: 10.1210/jendso/bvae062. eCollection 2024 Apr 6. J Endocr Soc. 2024. PMID: 38623381 Free PMC article.

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Modulatory effects of estrous cycle on ingestive behaviors and energy balance in young adult C57BL/6J mice maintained on a phytoestrogen-free diet.

Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL. Reho JJ, et al. Am J Physiol Regul Integr Comp Physiol. 2024 Mar 1;326(3):R242-R253. doi: 10.1152/ajpregu.00273.2023. Epub 2024 Jan 29. Am J Physiol Regul Integr Comp Physiol. 2024. PMID: 38284128 Free PMC article.

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Differences in Fluid, Electrolyte, and Energy Balance in C57BL/6J Mice (Mus musculus) in Metabolic Caging at Thermoneutral or Standard Room Temperatures.

Lawton SB, Grobe CC, Reho JJ, Raff H, Thulin JD, Jensen ES, Burnett CM, Segar JL, Grobe JL. Lawton SB, et al. J Am Assoc Lab Anim Sci. 2024 Mar 1;63(2):190-200. doi: 10.30802/AALAS-JAALAS-23-000091. Epub 2024 Jan 8. J Am Assoc Lab Anim Sci. 2024. PMID: 38191147 Free PMC article.

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Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice.

Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL. Ritter ML, et al. Physiol Genomics. 2024 Mar 1;56(3):265-275. doi: 10.1152/physiolgenomics.00042.2023. Epub 2023 Dec 25. Physiol Genomics. 2024. PMID: 38145289 Free PMC article.

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Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling.

Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Brozoski DT, Wackman KK, Lu KT, Kozak KN, Wells C, Fogo AB, Gibson-Corley KN, Kwitek AE, Sigmund CD, McIntosh JJ, Grobe JL. Opichka MA, et al. Sci Adv. 2023 Dec;9(48):eadg8118. doi: 10.1126/sciadv.adg8118. Epub 2023 Dec 1. Sci Adv. 2023. PMID: 38039359 Free PMC article.

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The Power of the Heterogeneous Stock Rat Founder Strains in Modeling Metabolic Disease.

Wagner VA, Holl KL, Clark KC, Reho JJ, Lehmler HJ, Wang K, Grobe JL, Dwinell MR, Raff H, Kwitek AE. Wagner VA, et al. Endocrinology. 2023 Nov 2;164(12):bqad157. doi: 10.1210/endocr/bqad157. Endocrinology. 2023. PMID: 37882530 Free PMC article.

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Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice.

Ziegler AA, Lawton SBR, Grobe CC, Reho JJ, Freudinger BP, Burnett CML, Nakagawa P, Grobe JL, Segar JL. Ziegler AA, et al. Am J Physiol Regul Integr Comp Physiol. 2023 Nov 1;325(5):R576-R592. doi: 10.1152/ajpregu.00137.2023. Epub 2023 Sep 18. Am J Physiol Regul Integr Comp Physiol. 2023. PMID: 37720996 Free PMC article.

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Sodium and Growth in Preterm Infants: A Review.

Araya BR, Ziegler AA, Grobe CC, Grobe JL, Segar JL. Araya BR, et al. Newborn (Clarksville). 2023;2(2):142-147. doi: 10.5005/jp-journals-11002-0060. Epub 2023 May 7. Newborn (Clarksville). 2023. PMID: 37614871 Free PMC article.

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Angiotensin AT_1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity.

Balapattabi K, Yavuz Y, Jiang J, Deng G, Mathieu NM, Ritter ML, Opichka MA, Reho JJ, McCorvy JD, Nakagawa P, Morselli LL, Mouradian GC Jr, Atasoy D, Cui H, Hodges MR, Sigmund CD, Grobe JL. Balapattabi K, et al. Cell Rep. 2023 Aug 29;42(8):112935. doi: 10.1016/j.celrep.2023.112935. Epub 2023 Aug 2. Cell Rep. 2023. PMID: 37540598 Free PMC article.

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Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature.

Grobe CC, Reho JJ, Brown-Williams D, Ziegler AA, Mathieu NM, Lawton SBR, Fekete EM, Brozoski DT, Wackman KK, Burnett CML, Nakagawa P, Sigmund CD, Segar JL, Grobe JL. Grobe CC, et al. Hypertension. 2023 Sep;80(9):1871-1880. doi: 10.1161/HYPERTENSIONAHA.122.20415. Epub 2023 Jul 20. Hypertension. 2023. PMID: 37470185 Free PMC article.

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Insights Into the Role of Angiotensin-II AT₁ Receptor-Dependent β-Arrestin Signaling in Cardiovascular Disease.

Mathieu NM, Nakagawa P, Grobe JL, Sigmund CD. Mathieu NM, et al. Hypertension. 2024 Jan;81(1):6-16. doi: 10.1161/HYPERTENSIONAHA.123.19419. Epub 2023 Jul 14. Hypertension. 2024. PMID: 37449411 Free PMC article. Review.

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Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure.

Wagner VA, Holl KL, Clark KC, Reho JJ, Dwinell MR, Lehmler HJ, Raff H, Grobe JL, Kwitek AE. Wagner VA, et al. Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. Toxicol Sci. 2023. PMID: 37191987 Free PMC article.

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Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice.

Deng Y, Dickey JE, Saito K, Deng G, Singh U, Jiang J, Toth BA, Zhu Z, Zingman LV, Resch JM, Grobe JL, Cui H. Deng Y, et al. Mol Metab. 2022 Dec;66:101622. doi: 10.1016/j.molmet.2022.101622. Epub 2022 Oct 25. Mol Metab. 2022. PMID: 36307046 Free PMC article.

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Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice.

Ritter ML, Deng G, Reho JJ, Deng Y, Sapouckey SA, Opichka MA, Balapattabi K, Wackman KK, Brozoski DT, Lu KT, Paradee WJ, Gibson-Corley KN, Cui H, Nakagawa P, Morselli LL, Sigmund CD, Grobe JL. Ritter ML, et al. Hypertension. 2022 Dec;79(12):2843-2853. doi: 10.1161/HYPERTENSIONAHA.122.20169. Epub 2022 Oct 19. Hypertension. 2022. PMID: 36259376 Free PMC article.

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ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.

Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD. Mathieu NM, et al. Hypertension. 2022 Nov;79(11):2480-2492. doi: 10.1161/HYPERTENSIONAHA.122.19863. Epub 2022 Aug 23. Hypertension. 2022. PMID: 36215165 Free PMC article.

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Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons.

Mouradian GC Jr, Liu P, Nakagawa P, Duffy E, Gomez Vargas J, Balapattabi K, Grobe JL, Sigmund CD, Hodges MR. Mouradian GC Jr, et al. Front Synaptic Neurosci. 2022 Jun 30;14:910820. doi: 10.3389/fnsyn.2022.910820. eCollection 2022. Front Synaptic Neurosci. 2022. PMID: 35844900 Free PMC article.

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Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice.

Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL. Oliveira V, et al. Am J Physiol Regul Integr Comp Physiol. 2022 Oct 1;323(4):R410-R421. doi: 10.1152/ajpregu.00091.2022. Epub 2022 Jul 11. Am J Physiol Regul Integr Comp Physiol. 2022. PMID: 35816717 Free PMC article.

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Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension.

Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD. Wu J, et al. Function (Oxf). 2022 Apr 8;3(3):zqac017. doi: 10.1093/function/zqac017. eCollection 2022. Function (Oxf). 2022. PMID: 35493997 Free PMC article.

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Melanocortin MC₄R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain.

Oliveira V, Riedl RA, Claflin KE, Mathieu NM, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL. Oliveira V, et al. Physiol Genomics. 2022 Jun 1;54(6):196-205. doi: 10.1152/physiolgenomics.00015.2022. Epub 2022 Apr 27. Physiol Genomics. 2022. PMID: 35476598 Free PMC article.

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Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet.

Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL. Patil CN, et al. Am J Physiol Regul Integr Comp Physiol. 2022 Jun 1;322(6):R467-R485. doi: 10.1152/ajpregu.00017.2022. Epub 2022 Mar 29. Am J Physiol Regul Integr Comp Physiol. 2022. PMID: 35348007 Free PMC article.

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Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents.

Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL. Reho JJ, et al. Front Physiol. 2022 Feb 25;13:855054. doi: 10.3389/fphys.2022.855054. eCollection 2022. Front Physiol. 2022. PMID: 35283781 Free PMC article.

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Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice.

Lozada-Fernández VV, deLeon O, Kellogg SL, Saravia FL, Hadiono MA, Atkinson SN, Grobe JL, Kirby JR. Lozada-Fernández VV, et al. mSystems. 2022 Feb 22;7(1):e0023021. doi: 10.1128/msystems.00230-21. Epub 2022 Jan 25. mSystems. 2022. PMID: 35076278 Free PMC article.

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NSAID-Induced Enteropathy Affects Regulation of Hepatic Glucose Production by Decreasing GLP-1 Secretion.

Herz H, Song Y, Ye Y, Tian L, Linden B, Abu El Haija M, Chu Y, Grobe JL, Lengeling RW, Mokadem M. Herz H, et al. Nutrients. 2021 Dec 28;14(1):120. doi: 10.3390/nu14010120. Nutrients. 2021. PMID: 35010994 Free PMC article.

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Short-term Housing in Metabolic Caging on Measures of Energy and Fluid Balance in Male C57BL/6J Mice ( Mus musculus).

Ziegler AA, Grobe CC, Reho JJ, Jensen ES, Thulin JD, Segar JL, Grobe JL. Ziegler AA, et al. J Am Assoc Lab Anim Sci. 2022 Mar 1;61(2):132-139. doi: 10.30802/AALAS-JAALAS-21-000087. Epub 2022 Jan 7. J Am Assoc Lab Anim Sci. 2022. PMID: 34996529 Free PMC article.

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Vascular Dysfunction in Preeclampsia.

Opichka MA, Rappelt MW, Gutterman DD, Grobe JL, McIntosh JJ. Opichka MA, et al. Cells. 2021 Nov 6;10(11):3055. doi: 10.3390/cells10113055. Cells. 2021. PMID: 34831277 Free PMC article. Review.

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Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake.

Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG. Xu H, et al. Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2708-2725. doi: 10.1161/ATVBAHA.121.316615. Epub 2021 Sep 23. Arterioscler Thromb Vasc Biol. 2021. PMID: 34551590 Free PMC article.

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Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice.

Nakagawa P, Gomez J, Lu KT, Grobe JL, Sigmund CD. Nakagawa P, et al. PLoS One. 2021 Jul 28;16(7):e0250807. doi: 10.1371/journal.pone.0250807. eCollection 2021. PLoS One. 2021. PMID: 34319999 Free PMC article.

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Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control.

Deng Y, Deng G, Grobe JL, Cui H. Deng Y, et al. Front Physiol. 2021 Jun 28;12:691226. doi: 10.3389/fphys.2021.691226. eCollection 2021. Front Physiol. 2021. PMID: 34262481 Free PMC article. Review.

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Activation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction.

De Silva TM, Modrick ML, Grobe JL, Faraci FM. De Silva TM, et al. Stroke. 2021 Jul;52(7):2404-2413. doi: 10.1161/STROKEAHA.121.034984. Epub 2021 Jun 10. Stroke. 2021. PMID: 34107734 Free PMC article.

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Maturational changes in sodium metabolism in periviable infants.

Segar JL, Grobe CC, Grobe JL. Segar JL, et al. Pediatr Nephrol. 2021 Nov;36(11):3693-3698. doi: 10.1007/s00467-021-05119-3. Epub 2021 May 19. Pediatr Nephrol. 2021. PMID: 34013388 Free PMC article.

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Gut Microbiota Represent a Major Thermogenic Biomass.

Riedl RA, Burnett CML, Pearson NA, Reho JJ, Mokadem M, Edwards RA, Kindel TL, Kirby JR, Grobe JL. Riedl RA, et al. Function (Oxf). 2021 Apr 15;2(3):zqab019. doi: 10.1093/function/zqab019. eCollection 2021. Function (Oxf). 2021. PMID: 33939772 Free PMC article.

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Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity.

Wagner VA, Clark KC, Carrillo-Sáenz L, Holl KA, Velez-Bermudez M, Simonsen D, Grobe JL, Wang K, Thurman A, Solberg Woods LC, Lehmler HJ, Kwitek AE. Wagner VA, et al. Toxicol Sci. 2021 May 27;181(2):246-261. doi: 10.1093/toxsci/kfab035. Toxicol Sci. 2021. PMID: 33755180 Free PMC article.

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BBSome ablation in SF1 neurons causes obesity without comorbidities.

Rouabhi M, Guo DF, Morgan DA, Zhu Z, López M, Zingman L, Grobe JL, Rahmouni K. Rouabhi M, et al. Mol Metab. 2021 Jun;48:101211. doi: 10.1016/j.molmet.2021.101211. Epub 2021 Mar 13. Mol Metab. 2021. PMID: 33722691 Free PMC article.

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EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension.

Wu J, Fang S, Lu KT, Wackman K, Schwartzman ML, Dikalov SI, Grobe JL, Sigmund CD. Wu J, et al. Hypertension. 2021 Apr;77(4):1399-1411. doi: 10.1161/HYPERTENSIONAHA.120.16518. Epub 2021 Mar 1. Hypertension. 2021. PMID: 33641369 Free PMC article.

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Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System.

Oliveira V, Kwitek AE, Sigmund CD, Morselli LL, Grobe JL. Oliveira V, et al. Hypertension. 2021 Apr;77(4):1061-1068. doi: 10.1161/HYPERTENSIONAHA.120.14513. Epub 2021 Feb 22. Hypertension. 2021. PMID: 33611936 Free PMC article. Review.

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Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model.

Gumusoglu SB, Chilukuri ASS, Hing BWQ, Scroggins SM, Kundu S, Sandgren JA, Santillan MK, Santillan DA, Grobe JL, Stevens HE. Gumusoglu SB, et al. Transl Psychiatry. 2021 Jan 28;11(1):79. doi: 10.1038/s41398-021-01205-0. Transl Psychiatry. 2021. PMID: 33510137 Free PMC article.

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Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes.

Segar JL, Grobe CC, Balapattabi K, Ritter ML, Reho JJ, Grobe JL. Segar JL, et al. Am J Physiol Regul Integr Comp Physiol. 2021 Apr 1;320(4):R438-R451. doi: 10.1152/ajpregu.00281.2020. Epub 2021 Jan 13. Am J Physiol Regul Integr Comp Physiol. 2021. PMID: 33439766 Free PMC article.

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β-Arrestin-Biased Agonist Targeting the Brain AT₁R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension.

Zanaty M, Seara FAC, Nakagawa P, Deng G, Mathieu NM, Balapattabi K, Karnik SS, Grobe JL, Sigmund CD. Zanaty M, et al. Hypertension. 2021 Feb;77(2):420-431. doi: 10.1161/HYPERTENSIONAHA.120.15793. Epub 2020 Nov 30. Hypertension. 2021. PMID: 33249862 Free PMC article.

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Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass.

Ye Y, Abu El Haija M, Morgan DA, Guo D, Song Y, Frank A, Tian L, Riedl RA, Burnett CML, Gao Z, Zhu Z, Shahi SK, Zarei K, Couvelard A, Poté N, Ribeiro-Parenti L, Bado A, Noureddine L, Bellizzi A, Kievit P, Mangalam AK, Zingman LV, Le Gall M, Grobe JL, Kaplan LM, Clegg D, Rahmouni K, Mokadem M. Ye Y, et al. Cell Rep. 2020 Oct 27;33(4):108270. doi: 10.1016/j.celrep.2020.108270. Cell Rep. 2020. PMID: 33113371 Free PMC article.

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Quantification of body fluid compartmentalization by combined time-domain nuclear magnetic resonance and bioimpedance spectroscopy.

Segar JL, Balapattabi K, Reho JJ, Grobe CC, Burnett CML, Grobe JL. Segar JL, et al. Am J Physiol Regul Integr Comp Physiol. 2021 Jan 1;320(1):R44-R54. doi: 10.1152/ajpregu.00227.2020. Epub 2020 Oct 21. Am J Physiol Regul Integr Comp Physiol. 2021. PMID: 33085913 Free PMC article.

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Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness.

Nuckols VR, Holwerda SW, Luehrs RE, DuBose LE, Stroud AK, Brandt D, Betz AM, Fiedorowicz JG, Scroggins SM, Santillan DA, Grobe JL, Sigmund CD, Santillan MK, Pierce GL. Nuckols VR, et al. Hypertension. 2020 Dec;76(6):1800-1807. doi: 10.1161/HYPERTENSIONAHA.120.15019. Epub 2020 Sep 21. Hypertension. 2020. PMID: 32951467 Free PMC article.

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Coupling of energy intake and energy expenditure across a temperature spectrum: impact of diet-induced obesity in mice.

Ono-Moore KD, Rutkowsky JM, Pearson NA, Williams DK, Grobe JL, Tolentino T, Lloyd KCK, Adams SH. Ono-Moore KD, et al. Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E472-E484. doi: 10.1152/ajpendo.00041.2020. Epub 2020 Jul 21. Am J Physiol Endocrinol Metab. 2020. PMID: 32691631 Free PMC article.

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Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.

Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD. Nakagawa P, et al. Hypertension. 2020 Aug;76(2):468-477. doi: 10.1161/HYPERTENSIONAHA.120.14972. Epub 2020 Jun 8. Hypertension. 2020. PMID: 32507043 Free PMC article.

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Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity.

Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Deng G, et al. Hypertension. 2020 Aug;76(2):589-597. doi: 10.1161/HYPERTENSIONAHA.120.15137. Epub 2020 Jun 8. Hypertension. 2020. PMID: 32507042 Free PMC article.

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Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension.

Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD. Wu J, et al. Cardiovasc Res. 2021 Jan 1;117(1):308-319. doi: 10.1093/cvr/cvaa147. Cardiovasc Res. 2021. PMID: 32428209 Free PMC article.

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Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner.

Lueschow SR, Kern SL, Gong H, Grobe JL, Segar JL, Carlson SJ, McElroy SJ. Lueschow SR, et al. Nutrients. 2020 Mar 26;12(4):900. doi: 10.3390/nu12040900. Nutrients. 2020. PMID: 32224880 Free PMC article.

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Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide.

Sapouckey SA, Morselli LL, Deng G, Patil CN, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL. Sapouckey SA, et al. Am J Physiol Regul Integr Comp Physiol. 2020 May 1;318(5):R855-R869. doi: 10.1152/ajpregu.00297.2019. Epub 2020 Mar 18. Am J Physiol Regul Integr Comp Physiol. 2020. PMID: 32186897 Free PMC article.

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A colorful view of the brain renin-angiotensin system.

Sigmund CD, Grobe JL. Sigmund CD, et al. Hypertens Res. 2020 Apr;43(4):357-359. doi: 10.1038/s41440-020-0396-2. Epub 2020 Jan 17. Hypertens Res. 2020. PMID: 31953528 Free PMC article. No abstract available.

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Fetal storage of osmotically inactive sodium.

Segar JL, Grobe CC, Grobe JL. Segar JL, et al. Am J Physiol Regul Integr Comp Physiol. 2020 Mar 1;318(3):R512-R514. doi: 10.1152/ajpregu.00336.2019. Epub 2020 Jan 15. Am J Physiol Regul Integr Comp Physiol. 2020. PMID: 31940233 Free PMC article.

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The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation.

Nakagawa P, Gomez J, Grobe JL, Sigmund CD. Nakagawa P, et al. Curr Hypertens Rep. 2020 Jan 10;22(1):7. doi: 10.1007/s11906-019-1011-2. Curr Hypertens Rep. 2020. PMID: 31925571 Free PMC article. Review.

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Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.

Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Perschbacher KJ, et al. Hypertension. 2020 Feb;75(2):569-579. doi: 10.1161/HYPERTENSIONAHA.119.14056. Epub 2019 Dec 23. Hypertension. 2020. PMID: 31865781 Free PMC article.

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Central EP3 (E Prostanoid 3) Receptors Mediate Salt-Sensitive Hypertension and Immune Activation.

Xiao L, Itani HA, do Carmo LS, Carver LS, Breyer RM, Harrison DG. Xiao L, et al. Hypertension. 2019 Dec;74(6):1507-1515. doi: 10.1161/HYPERTENSIONAHA.119.13850. Epub 2019 Nov 4. Hypertension. 2019. PMID: 31679420 Free PMC article.

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The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors.

Guo DF, Lin Z, Wu Y, Searby C, Thedens DR, Richerson GB, Usachev YM, Grobe JL, Sheffield VC, Rahmouni K. Guo DF, et al. Diabetes. 2019 Aug;68(8):1591-1603. doi: 10.2337/db18-1088. Epub 2019 May 24. Diabetes. 2019. PMID: 31127052 Free PMC article.

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Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension.

Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD. Nair AR, et al. Hypertension. 2019 Jul;74(1):173-183. doi: 10.1161/HYPERTENSIONAHA.119.13101. Epub 2019 May 20. Hypertension. 2019. PMID: 31104564 Free PMC article.

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Comparison of the Effects of High-Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems.

Soto JE, Burnett CML, Ten Eyck P, Abel ED, Grobe JL. Soto JE, et al. Obesity (Silver Spring). 2019 May;27(5):793-802. doi: 10.1002/oby.22441. Epub 2019 Mar 28. Obesity (Silver Spring). 2019. PMID: 30938081 Free PMC article.

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Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions.

Saito K, Davis KC, Morgan DA, Toth BA, Jiang J, Singh U, Berglund ED, Grobe JL, Rahmouni K, Cui H. Saito K, et al. Diabetes. 2019 Jun;68(6):1210-1220. doi: 10.2337/db18-1167. Epub 2019 Mar 20. Diabetes. 2019. PMID: 30894367 Free PMC article.

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Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure.

Ameka M, Markan KR, Morgan DA, BonDurant LD, Idiga SO, Naber MC, Zhu Z, Zingman LV, Grobe JL, Rahmouni K, Potthoff MJ. Ameka M, et al. Sci Rep. 2019 Jan 24;9(1):630. doi: 10.1038/s41598-018-37198-y. Sci Rep. 2019. PMID: 30679672 Free PMC article.

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The renin-angiotensin system in the arcuate nucleus controls resting metabolic rate.

Deng G, Grobe JL. Deng G, et al. Curr Opin Nephrol Hypertens. 2019 Mar;28(2):120-127. doi: 10.1097/MNH.0000000000000477. Curr Opin Nephrol Hypertens. 2019. PMID: 30531199 Free PMC article. Review.

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Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice.

Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Sandgren JA, et al. JCI Insight. 2018 Oct 4;3(19):e99403. doi: 10.1172/jci.insight.99403. JCI Insight. 2018. PMID: 30282823 Free PMC article.

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Regulators of G protein signaling in cardiovascular function during pregnancy.

Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL. Perschbacher KJ, et al. Physiol Genomics. 2018 Aug 1;50(8):590-604. doi: 10.1152/physiolgenomics.00037.2018. Epub 2018 Apr 27. Physiol Genomics. 2018. PMID: 29702036 Free PMC article. Review.

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Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin.

Morselli LL, Claflin KE, Cui H, Grobe JL. Morselli LL, et al. Curr Hypertens Rep. 2018 Mar 19;20(3):25. doi: 10.1007/s11906-018-0824-8. Curr Hypertens Rep. 2018. PMID: 29556733 Free PMC article. Review.

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Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia.

Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Scroggins SM, et al. Clin Sci (Lond). 2018 Feb 14;132(3):419-436. doi: 10.1042/CS20171059. Print 2018 Feb 14. Clin Sci (Lond). 2018. PMID: 29371289 Free PMC article.

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Angiotensin AT_1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin.

Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Sandgren JA, et al. Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1;314(6):R770-R780. doi: 10.1152/ajpregu.00435.2017. Epub 2018 Jan 24. Am J Physiol Regul Integr Comp Physiol. 2018. PMID: 29364700 Free PMC article.

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Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism.

Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Sapouckey SA, et al. Physiol Genomics. 2017 Dec 1;49(12):722-732. doi: 10.1152/physiolgenomics.00087.2017. Epub 2017 Oct 6. Physiol Genomics. 2017. PMID: 28986397 Free PMC article. Review.

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MRAP2 regulates ghrelin receptor signaling and hunger sensing.

Srisai D, Yin TC, Lee AA, Rouault AAJ, Pearson NA, Grobe JL, Sebag JA. Srisai D, et al. Nat Commun. 2017 Sep 28;8(1):713. doi: 10.1038/s41467-017-00747-6. Nat Commun. 2017. PMID: 28959025 Free PMC article.

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Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism.

Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD. Shinohara K, et al. Hypertension. 2017 Nov;70(5):990-997. doi: 10.1161/HYPERTENSIONAHA.117.09923. Epub 2017 Sep 5. Hypertension. 2017. PMID: 28874461 Free PMC article.

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Comprehensive Assessments of Energy Balance in Mice.

Grobe JL. Grobe JL. Methods Mol Biol. 2017;1614:123-146. doi: 10.1007/978-1-4939-7030-8_10. Methods Mol Biol. 2017. PMID: 28500600 Free PMC article.

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Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice.

Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD. Agassandian K, et al. Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312(6):R973-R981. doi: 10.1152/ajpregu.00511.2016. Epub 2017 May 10. Am J Physiol Regul Integr Comp Physiol. 2017. PMID: 28490451 Free PMC article.

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The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension.

Riedl RA, Atkinson SN, Burnett CML, Grobe JL, Kirby JR. Riedl RA, et al. Curr Hypertens Rep. 2017 Apr;19(4):27. doi: 10.1007/s11906-017-0721-6. Curr Hypertens Rep. 2017. PMID: 28316052 Free PMC article. Review.

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Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism.

Claflin KE, Sandgren JA, Lambertz AM, Weidemann BJ, Littlejohn NK, Burnett CM, Pearson NA, Morgan DA, Gibson-Corley KN, Rahmouni K, Grobe JL. Claflin KE, et al. J Clin Invest. 2017 Apr 3;127(4):1414-1424. doi: 10.1172/JCI88641. Epub 2017 Mar 6. J Clin Invest. 2017. PMID: 28263184 Free PMC article.

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