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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 4
1948 3
1949 3
1950 3
1951 11
1952 9
1953 6
1954 12
1955 7
1956 5
1957 14
1958 14
1959 17
1960 19
1961 19
1962 23
1963 46
1964 61
1965 70
1966 179
1967 216
1968 212
1969 197
1970 209
1971 186
1972 199
1973 230
1974 295
1975 367
1976 404
1977 601
1978 980
1979 1192
1980 15681
1981 33525
1982 34549
1983 35008
1984 36718
1985 37421
1986 38591
1987 39950
1988 41049
1989 42689
1990 44642
1991 45900
1992 46519
1993 47250
1994 48722
1995 49132
1996 49312
1997 49643
1998 50587
1999 52158
2000 54665
2001 56074
2002 59138
2003 63318
2004 70961
2005 77644
2006 86252
2007 92820
2008 102893
2009 109576
2010 118744
2011 127716
2012 132172
2013 137200
2014 138041
2015 138701
2016 134112
2017 128466
2018 129550
2019 130092
2020 141224
2021 145523
2022 121953
2023 25019
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Methylation-Based Biological Age and Hypertension Prevalence and Incidence.
Kresovich JK, Sandler DP, Taylor JA. Kresovich JK, et al. Hypertension. 2023 Mar 28. doi: 10.1161/HYPERTENSIONAHA.122.20796. Online ahead of print. Hypertension. 2023. PMID: 36974720
New incident cases of hypertension during follow-up were identified via self-report on annual health questionnaires. RESULTS: All 3 DNA methylation metrics of biological age were positively associated with prevalent hypertension at baseline (per 1-SD increase; PhenoAgeAcce …
New incident cases of hypertension during follow-up were identified via self-report on annual health questionnaires. RESULTS: All 3 D …
Relationships among clinicians are crucial to successful palliative care integration: a qualitative study in lung cancer.
Sullivan DR, Vranas KC, Delorit M, Golden SE, Slatore CG, Ganzini L, Hansen L. Sullivan DR, et al. Future Oncol. 2023 Mar 28. doi: 10.2217/fon-2022-0958. Online ahead of print. Future Oncol. 2023. PMID: 36974605
Materials & methods: Semistructured qualitative interviews were conducted with palliative care and lung cancer clinicians and analyzed using traditional content analysis. 23 clinicians were interviewed from geographically dispersed hospitals within a national healthcar …
Materials & methods: Semistructured qualitative interviews were conducted with palliative care and lung cancer clinicians and analyzed u …
Anorexia in Medicare Fee-for-Service Beneficiaries: A Claims-Based Analysis of Epidemiology and Mortality.
Dagenais S, Fielding RA, Clark S, Cantu C, Prasad S, Groarke JD. Dagenais S, et al. J Nutr Health Aging. 2023;27(3):184-191. doi: 10.1007/s12603-023-1882-4. J Nutr Health Aging. 2023. PMID: 36973924
The objective of this study was to estimate the annual prevalence and incidence of anorexia in older adults with Medicare fee-for-service (FFS) health insurance. DESIGN: Retrospective and observational analysis of administrative health insurance claims data. ...Furt …
The objective of this study was to estimate the annual prevalence and incidence of anorexia in older adults with Medicare fee-for-service (F …
Cardiovascular magnetic resonance for evaluation of cardiac involvement in COVID-19: recommendations by the Society for Cardiovascular Magnetic Resonance.
Ferreira VM, Plein S, Wong TC, Tao Q, Raisi-Estabragh Z, Jain SS, Han Y, Ojha V, Bluemke DA, Hanneman K, Weinsaft J, Vidula MK, Ntusi NAB, Schulz-Menger J, Kim J. Ferreira VM, et al. J Cardiovasc Magn Reson. 2023 Mar 27;25(1):21. doi: 10.1186/s12968-023-00933-0. J Cardiovasc Magn Reson. 2023. PMID: 36973744 Review.
Barriers to early diagnosis of cervical cancer: a mixed-method study in Côte d'Ivoire, West Africa.
Plaisy MK, Boni SP, Coffie PA, Tanon A, Innocent A, Horo A, Dabis F, Bekelynck A, Jaquet A; IeDEA West Africa Collaboration. Plaisy MK, et al. BMC Womens Health. 2023 Mar 27;23(1):135. doi: 10.1186/s12905-023-02264-9. BMC Womens Health. 2023. PMID: 36973736
BACKGROUND: Cervical cancer, a major public health problem in many developing countries, is usually associated with a poor survival related to an advanced disease at diagnosis. ...Among them, 18.9% were living with HIV and only 9.5% were covered by a health insuranc …
BACKGROUND: Cervical cancer, a major public health problem in many developing countries, is usually associated with a poor survival r …
Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins.
Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T. Agam G, et al. Nat Methods. 2023 Mar 27. doi: 10.1038/s41592-023-01807-0. Online ahead of print. Nat Methods. 2023. PMID: 36973549
Intrinsic activity development unfolds along a sensorimotor-association cortical axis in youth.
Sydnor VJ, Larsen B, Seidlitz J, Adebimpe A, Alexander-Bloch AF, Bassett DS, Bertolero MA, Cieslak M, Covitz S, Fan Y, Gur RE, Gur RC, Mackey AP, Moore TM, Roalf DR, Shinohara RT, Satterthwaite TD. Sydnor VJ, et al. Nat Neurosci. 2023 Mar 27. doi: 10.1038/s41593-023-01282-y. Online ahead of print. Nat Neurosci. 2023. PMID: 36973514
Leveraging resting-state functional MRI (fMRI) data from 1,033 youths (ages 8-23 years), we find that this stereotyped refinement of intrinsic activity occurs during human development and provides evidence for a cortical gradient of neurodevelopmental change. ...
Leveraging resting-state functional MRI (fMRI) data from 1,033 youths (ages 8-23 years), we find that this stereotyped refinement of intrins …
Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway.
Park WY, Gray JM, Holewinski RJ, Andresson T, So JY, Carmona-Rivera C, Hollander MC, Yang HH, Lee M, Kaplan MJ, Cappell SD, Yang L. Park WY, et al. Nat Cancer. 2023 Mar;4(3):419-435. doi: 10.1038/s43018-023-00524-z. Epub 2023 Mar 27. Nat Cancer. 2023. PMID: 36973439
The chromatin-bound RAGE ligand S100a4 activates RAGE receptors in neighboring surviving tumor cells, leading to Erk activation. In addition, we identified nuclear expulsion products in human patients with breast, bladder and lung cancer and a nuclear expulsion signature c …
The chromatin-bound RAGE ligand S100a4 activates RAGE receptors in neighboring surviving tumor cells, leading to Erk activation. In addition …
Monocyte-derived macrophages contain persistent latent HIV reservoirs.
Veenhuis RT, Abreu CM, Costa PAG, Ferreira EA, Ratliff J, Pohlenz L, Shirk EN, Rubin LH, Blankson JN, Gama L, Clements JE. Veenhuis RT, et al. Nat Microbiol. 2023 Mar 27. doi: 10.1038/s41564-023-01349-3. Online ahead of print. Nat Microbiol. 2023. PMID: 36973419
The development of persistent cellular reservoirs of latent human immunodeficiency virus (HIV) is a critical obstacle to viral eradication since viral rebound takes place once anti-retroviral therapy (ART) is interrupted. ...However, how myeloid cells contribute to the siz …
The development of persistent cellular reservoirs of latent human immunodeficiency virus (HIV) is a critical obstacle to viral eradic …
Prophylactic indomethacin, antenatal betamethasone, and the risk of intestinal perforation in infants <28 weeks' gestation.
Clyman RI, Hills NK. Clyman RI, et al. J Perinatol. 2023 Mar 27. doi: 10.1038/s41372-023-01653-0. Online ahead of print. J Perinatol. 2023. PMID: 36973384
OBJECTIVE: To determine if intestinal perforations before 14 days (either spontaneous (SIP) or necrotizing enterocolitis-induced) are increased when infants who received antenatal betamethasone shortly before birth are treated with prophylactic indomethacin (PINDO). STUDY DESIGN: …
OBJECTIVE: To determine if intestinal perforations before 14 days (either spontaneous (SIP) or necrotizing enterocolitis-induced) are increa …
Identification of clinical factors associated with timing and duration of spontaneous regression of retinopathy of prematurity not requiring treatment.
Schoephoerster J, Roston S, Lunos S, Ramel SE, Anderson J, Georgieff MK, Ingolfsland EC. Schoephoerster J, et al. J Perinatol. 2023 Mar 27. doi: 10.1038/s41372-023-01649-w. Online ahead of print. J Perinatol. 2023. PMID: 36973383
Outcomes were PMA at greatest severity of ROP (PMA MSROP), at which regression began, at time of complete vascularization (PMA CV), and regression duration. Pearson's correlation coefficients, t-tests, or analyses of variance were calculated. ...
Outcomes were PMA at greatest severity of ROP (PMA MSROP), at which regression began, at time of complete vascularization (PMA CV), and regr …
Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure.
Bruce MR, Couch ACM, Grant S, McLellan J, Ku K, Chang C, Bachman A, Matson M, Berman RF, Maddock RJ, Rowland D, Kim E, Ponzini MD, Harvey D, Taylor SL, Vernon AC, Bauman MD, Van de Water J. Bruce MR, et al. Mol Psychiatry. 2023 Mar 27. doi: 10.1038/s41380-023-02020-3. Online ahead of print. Mol Psychiatry. 2023. PMID: 36973347
MAR-ASD rat offspring displayed a reduction in pup ultrasonic vocalizations and a pronounced deficit in social play behavior when allowed to freely interact with a novel partner. ...
MAR-ASD rat offspring displayed a reduction in pup ultrasonic vocalizations and a pronounced deficit in social play behavior when all …
Genome-wide association study of population-standardised cognitive performance phenotypes in a rural South African community.
Soo CC, Brandenburg JT, Nebel A, Tollman S, Berkman L, Ramsay M, Choudhury A. Soo CC, et al. Commun Biol. 2023 Mar 27;6(1):328. doi: 10.1038/s42003-023-04636-1. Commun Biol. 2023. PMID: 36973338
Cognitive function is an indicator for global physical and mental health, and cognitive impairment has been associated with poorer life outcomes and earlier mortality. ...
Cognitive function is an indicator for global physical and mental health, and cognitive impairment has been associated with poorer li …
Structural and functional analysis of human pannexin 2 channel.
He Z, Zhao Y, Rau MJ, Fitzpatrick JAJ, Sah R, Hu H, Yuan P. He Z, et al. Nat Commun. 2023 Mar 27;14(1):1712. doi: 10.1038/s41467-023-37413-z. Nat Commun. 2023. PMID: 36973289
However, the molecular basis of PANX2 channel function remains largely unknown. Here, we present a cryo-electron microscopy structure of human PANX2, which reveals pore properties contrasting with those of the intensely studied paralog PANX1. ...
However, the molecular basis of PANX2 channel function remains largely unknown. Here, we present a cryo-electron microscopy structure of …
Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation.
Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC, Liao Z, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W, Huff CD, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC, Hung MC, Zhao Z, Van Nostrand EL, Zhao R, Lee DF. Xu A, et al. Nat Commun. 2023 Mar 27;14(1):1694. doi: 10.1038/s41467-023-37398-9. Nat Commun. 2023. PMID: 36973285
Helicobacter pylori initiates successful gastric colonization by utilizing L-lactate to promote complement resistance.
Hu S, Ottemann KM. Hu S, et al. Nat Commun. 2023 Mar 27;14(1):1695. doi: 10.1038/s41467-023-37160-1. Nat Commun. 2023. PMID: 36973281
H. pylori uses uptake of the host molecule L-lactate to create a complement-resistant state that relies on blocking the deposition of the active complement C4b component on H. pylori's surface. H. pylori mutants unable to achieve this complement-resistant state have a sign …
H. pylori uses uptake of the host molecule L-lactate to create a complement-resistant state that relies on blocking the deposition of the ac …
Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma.
Wu Y, Terekhanova NV, Caravan W, Naser Al Deen N, Lal P, Chen S, Mo CK, Cao S, Li Y, Karpova A, Liu R, Zhao Y, Shinkle A, Strunilin I, Weimholt C, Sato K, Yao L, Serasanambati M, Yang X, Wyczalkowski M, Zhu H, Zhou DC, Jayasinghe RG, Mendez D, Wendl MC, Clark D, Newton C, Ruan Y, Reimers MA, Pachynski RK, Kinsinger C, Jewell S, Chan DW, Zhang H, Chaudhuri AA, Chheda MG, Humphreys BD, Mesri M, Rodriguez H, Hsieh JJ, Ding L, Chen F. Wu Y, et al. Nat Commun. 2023 Mar 27;14(1):1681. doi: 10.1038/s41467-023-37211-7. Nat Commun. 2023. PMID: 36973268
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34 and 28 human clear cell renal cell carcinoma (ccRCC) specimens, …
Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights …
Protection from SARS-CoV-2 Variants by MVAs expressing matched or mismatched S administered intranasally to mice.
Cotter CA, Americo JL, Earl PL, Moss B. Cotter CA, et al. NPJ Vaccines. 2023 Mar 27;8(1):47. doi: 10.1038/s41541-023-00645-7. NPJ Vaccines. 2023. PMID: 36973267 Free PMC article.
SARS-CoV-2 vaccines prevent severe disease but are less efficient in averting infection and transmission of variant strains, making it imperative to explore ways of enhancing protection. Use of inbred mice expressing the human SARS-CoV-2 receptor facilitates such investiga …
SARS-CoV-2 vaccines prevent severe disease but are less efficient in averting infection and transmission of variant strains, making it imper …
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases.
Trastoy B, Du JJ, Cifuente JO, Rudolph L, García-Alija M, Klontz EH, Deredge D, Sultana N, Huynh CG, Flowers MW, Li C, Sastre DE, Wang LX, Corzana F, Mallagaray A, Sundberg EJ, Guerin ME. Trastoy B, et al. Nat Commun. 2023 Mar 27;14(1):1705. doi: 10.1038/s41467-023-37215-3. Nat Commun. 2023. PMID: 36973249
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. ...
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory …
Assessment of caregiver burden prior to implantation of left ventricular assist device: A national survey.
Baird AS, Thompson JS, Fitzgerald MD, Mosley BS, Matlock DD, Allen LA, Mcllvennan CK. Baird AS, et al. J Heart Lung Transplant. 2023 Mar 1:S1053-2498(23)01567-X. doi: 10.1016/j.healun.2023.02.1501. Online ahead of print. J Heart Lung Transplant. 2023. PMID: 36973094
RESULTS: Responses were obtained from 191 registered nurses, 109 advance practice providers, 71 physicians, 59 social workers, and 40 others representing 132 LVAD programs; 125 of 173 total United States programs were included in the final analysis. While most programs (83 …
RESULTS: Responses were obtained from 191 registered nurses, 109 advance practice providers, 71 physicians, 59 social workers, and 40 …
Alterations to biomarkers related to long-term exposure to diesel exhaust at concentrations below occupational exposure limits in the European Union and the USA.
Wong JY, Blechter B, Bassig BA, Dai Y, Vermeulen R, Hu W, Rahman ML, Duan H, Niu Y, Downward GS, Leng S, Ji BT, Fu W, Xu J, Meliefste K, Zhou B, Yang J, Ren D, Ye M, Jia X, Meng T, Bin P, Hosgood HD, Rothman N, Silverman DT, Zheng Y, Lan Q. Wong JY, et al. Occup Environ Med. 2023 Mar 27:oemed-2022-108719. doi: 10.1136/oemed-2022-108719. Online ahead of print. Occup Environ Med. 2023. PMID: 36972977
We analysed each biomarker at EC concentrations below the US Mine Safety and Health Administration (MSHA) OEL (<106 g/m(3)), below the European Union (EU) OEL (<50 g/m(3)) and below the American Conference of Governmental Industrial Hygienists (ACGIH) recommendation …
We analysed each biomarker at EC concentrations below the US Mine Safety and Health Administration (MSHA) OEL (<106 g/m(3)), below …
Impact of testosterone use on the vaginal microbiota of transgender men, including susceptibility to bacterial vaginosis: study protocol for a prospective, observational study.
Muzny CA, Van Gerwen OT, Schroeder JA, Kay-Duncan ES, Siwakoti K, Aaron KJ, Eastlund IC, Graves KJ, Elnaggar JH, Tamhane A, Long D, Van Wagoner N, Toh E, Taylor CM. Muzny CA, et al. BMJ Open. 2023 Mar 27;13(3):e073068. doi: 10.1136/bmjopen-2023-073068. BMJ Open. 2023. PMID: 36972958
ETHICS AND DISSEMINATION: This protocol is approved through the single Institutional Review Board mechanism by the University of Alabama at Birmingham. External relying sites are the Louisiana State University Health Sciences Center, New Orleans Human Research Prote …
ETHICS AND DISSEMINATION: This protocol is approved through the single Institutional Review Board mechanism by the University of Alabama at …
Society of Interventional Radiology - American College of Radiology Standardized Report Based Data Registry: Early Observations and Reflections from 2017-2019 Biopsy Report Data of Select Sites.
Charalel RA, Lewis PB, Salei A, Cantos A, Dubel G, Baskin K, Kassin M, Brook O, Aldulaimi R, Kalva S, Ward TJ, Durack J, Shah R. Charalel RA, et al. J Vasc Interv Radiol. 2023 Mar 25:S1051-0443(23)00222-1. doi: 10.1016/j.jvir.2023.03.010. Online ahead of print. J Vasc Interv Radiol. 2023. PMID: 36972844 No abstract available.
Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models.
Chen X, Gula H, Pius T, Ou C, Gomozkova M, Wang LX, Schneewind O, Missiakas D. Chen X, et al. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2220765120. doi: 10.1073/pnas.2220765120. Epub 2023 Mar 27. Proc Natl Acad Sci U S A. 2023. PMID: 36972444
Correlating with the relative abundance of each receptor, 3F6-mIgG2a-dependent protection in C57BL/6J mice showed a greater reliance for FcgammaRIV while protection in BALB/cJ mice was only impaired upon neutralization of CR3. Thus, 3F6-based clearance of S. aureus in mice …
Correlating with the relative abundance of each receptor, 3F6-mIgG2a-dependent protection in C57BL/6J mice showed a greater reliance for Fcg …
Statins enhance the efficacy of HER2-targeting radioligand therapy in drug-resistant gastric cancers.
Rao Y, Samuels Z, Carter LM, Monette S, Panikar SS, Pereira PMR, Lewis JS. Rao Y, et al. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2220413120. doi: 10.1073/pnas.2220413120. Epub 2023 Mar 27. Proc Natl Acad Sci U S A. 2023. PMID: 36972439
Human epidermal growth factor receptor 2 (HER2) is overexpressed in various cancer types. ...
Human epidermal growth factor receptor 2 (HER2) is overexpressed in various cancer types. ...
A general mechanism for transcription bubble nucleation in bacteria.
Mueller AU, Chen J, Wu M, Chiu C, Nixon BT, Campbell EA, Darst SA. Mueller AU, et al. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2220874120. doi: 10.1073/pnas.2220874120. Epub 2023 Mar 27. Proc Natl Acad Sci U S A. 2023. PMID: 36972428
The Relationship of Continuity of Care, Polypharmacy and Medication Appropriateness: A Systematic Review of Observational Studies.
Lampe D, Grosser J, Gensorowsky D, Witte J, Muth C, van den Akker M, Dinh TS, Greiner W. Lampe D, et al. Drugs Aging. 2023 Mar 27. doi: 10.1007/s40266-023-01022-8. Online ahead of print. Drugs Aging. 2023. PMID: 36972012
INTRODUCTION: Worldwide, polypharmacy and medication appropriateness-related outcomes (MARO) are growing public health concerns associated with potentially inappropriate prescribing, adverse health effects, and avoidable costs to health systems. ...COC measur …
INTRODUCTION: Worldwide, polypharmacy and medication appropriateness-related outcomes (MARO) are growing public health concerns assoc …
Vaccines prevent reinduction of rheumatoid arthritis symptoms in collagen-induced arthritis mouse model.
Thumsi A, Swaminathan SJ, Mangal JL, Suresh AP, Acharya AP. Thumsi A, et al. Drug Deliv Transl Res. 2023 Mar 27. doi: 10.1007/s13346-023-01333-8. Online ahead of print. Drug Deliv Transl Res. 2023. PMID: 36971998
Upon re-induction, a significant delay in the reappearance of clinical symptoms in the paKG(PFK15 + bc2) microparticle treatment group was observed as compared to equal or higher doses of the clinically utilized U.S. Food and Drug Administration (FDA)-approved drug, …
Upon re-induction, a significant delay in the reappearance of clinical symptoms in the paKG(PFK15 + bc2) microparticle treatment group was o …
Mouse Models for Atopic Dermatitis.
Sakamoto K, Nagao K. Sakamoto K, et al. Curr Protoc. 2023 Mar;3(3):e709. doi: 10.1002/cpz1.709. Curr Protoc. 2023. PMID: 36971661
The combination of these approaches enables accurate characterization of the degree of inflammation, type of inflammatory infiltrate, and localization of immune infiltrates. Published 2023. This article is a U.S. Government work and is in the public domain in the US …
The combination of these approaches enables accurate characterization of the degree of inflammation, type of inflammatory infiltrate, and lo …
Extrachromosomal Amplification of Human Papillomavirus Episomes is a Mechanism of Cervical Carcinogenesis.
Rossi NM, Dai J, Xie Y, Wangsa D, Heselmeyer-Haddad K, Lou H, Boland JF, Yeager M, Orozco R, Alvirez Freites E, Mirabello L, Gharzouzi E, Dean M. Rossi NM, et al. Cancer Res. 2023 Mar 27:CAN-22-3030. doi: 10.1158/0008-5472.CAN-22-3030. Online ahead of print. Cancer Res. 2023. PMID: 36971511
HPV16 is the most oncogenic type of human papillomavirus (HPV). Integration of HPV into the human genome is an important mechanism of carcinogenesis but is absent in at least 30% of HPV16+ tumors. ...Tumors with putative multimer HPV integrations displayed HPV multi …
HPV16 is the most oncogenic type of human papillomavirus (HPV). Integration of HPV into the human genome is an important mecha …
Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow.
Tonks NK. Tonks NK. IUBMB Life. 2023 Apr;75(4):337-352. doi: 10.1002/iub.2716. IUBMB Life. 2023. PMID: 36971473
In October 2020, we were finally able to gather for a celebration of Eddy Fischer's 100th birthday. As with many other events, COVID had disrupted and restricted preparations for the gathering, which ultimately was held via ZOOM. ...This tribute to Eddy is based upon the t …
In October 2020, we were finally able to gather for a celebration of Eddy Fischer's 100th birthday. As with many other events, COVID …
Specific resistance prevents the evolution of general resistance and facilitates disease emergence.
Hulse SV, Antonovics J, Hood ME, Bruns EL. Hulse SV, et al. J Evol Biol. 2023 Mar 27. doi: 10.1111/jeb.14170. Online ahead of print. J Evol Biol. 2023. PMID: 36971466
Our results demonstrate the importance of considering the joint evolution of multiple forms of resistance when evaluating a population's susceptibility to foreign pathogens....
Our results demonstrate the importance of considering the joint evolution of multiple forms of resistance when evaluating a population's
Chromatin access regulates the formation of Müller glia-derived progenitor cells in the retina.
Campbell WA, El-Hodiri HM, Torres D, Hawthorn EC, Kelly LE, Volkov L, Akanonu D, Fischer AJ. Campbell WA, et al. Glia. 2023 Mar 27. doi: 10.1002/glia.24366. Online ahead of print. Glia. 2023. PMID: 36971459
However, little is known about how chromatin access and epigenetic gene silencing influence mature glial cells and retinal regeneration. Herein, we investigate the expression and functions of S-adenosylhomocysteine hydrolase (SAHH; AHCY) and histone methyltransferases (HMT …
However, little is known about how chromatin access and epigenetic gene silencing influence mature glial cells and retinal regeneration. Her …
Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
Samadi M, Hales CA, Lustberg DJ, Farris S, Ross MR, Zhao M, Hepler JR, Harbin NH, Robinson ESJ, Banks PJ, Bashir ZI, Dudek SM. Samadi M, et al. Hippocampus. 2023 Mar 27. doi: 10.1002/hipo.23529. Online ahead of print. Hippocampus. 2023. PMID: 36971428
In addition, we found that exogenous application of STEP could rescue mGluR-LTD in RGS14 KO slices. Supporting a role for CA2 synaptic plasticity in social cognition, we found that RGS14 KO mice had impaired social recognition memory as assessed in a social d …
In addition, we found that exogenous application of STEP could rescue mGluR-LTD in RGS14 KO slices. Supporting a role for CA2 synaptic plast …
Polygenic risk scores for the prediction of common cancers in East Asians: A population-based prospective cohort study.
Ho PJ, Tan IB, Chong DQ, Khor CC, Yuan JM, Koh WP, Dorajoo R, Li J. Ho PJ, et al. Elife. 2023 Mar 27;12:e82608. doi: 10.7554/eLife.82608. Online ahead of print. Elife. 2023. PMID: 36971353
The Singapore Chinese Health Study was supported by grants from the National Medical Research Council, Singapore (NMRC/CIRG/1456/2016) and the U.S. National Institutes of Health [NIH] (R01 CA144034 and UM1 CA182876)....
The Singapore Chinese Health Study was supported by grants from the National Medical Research Council, Singapore (NMRC/CIRG/14 …
Transcriptional drifts associated with environmental changes in endothelial cells.
Afshar Y, Ma F, Quach A, Jeong A, Sunshine HL, Freitas V, Jami-Alahmadi Y, Helaers R, Li X, Pellegrini M, Wohlschlegel JA, Romanoski CE, Vikkula M, Iruela-Arispe L. Afshar Y, et al. Elife. 2023 Mar 27;12:e81370. doi: 10.7554/eLife.81370. Online ahead of print. Elife. 2023. PMID: 36971339
Environmental cues, such as physical forces and heterotypic cell interactions play a critical role in cell function, yet their collective contributions to transcriptional changes are unclear. Focusing on human endothelial cells, we performed broad individual sample analysi …
Environmental cues, such as physical forces and heterotypic cell interactions play a critical role in cell function, yet their collective co …
CD193 (CCR3) expression by B cells correlates with reduced IgE production in paediatric schistosomiasis.
Onkanga IO, Sang H, Hamilton R, Ondigo BN, Jaoko W, Odiere MR, Ganley-Leal L. Onkanga IO, et al. Parasite Immunol. 2023 Mar 27:e12979. doi: 10.1111/pim.12979. Online ahead of print. Parasite Immunol. 2023. PMID: 36971331
CD193 plays a role in directing granulocytes into sites of allergic-like inflammation in the mucosa, but little is known about its functional significance on human B cells. We sought to characterize CD193 expression and its relationship with S. mansoni infection. .. …
CD193 plays a role in directing granulocytes into sites of allergic-like inflammation in the mucosa, but little is known about its functiona …
Recent progress and structural analyses of domain-selective BET inhibitors.
Divakaran A, Harki DA, Pomerantz WCK. Divakaran A, et al. Med Res Rev. 2023 Mar 27. doi: 10.1002/med.21942. Online ahead of print. Med Res Rev. 2023. PMID: 36971240 Review.
Epigenetic mechanisms for controlling gene expression through heritable modifications to DNA, RNA, and proteins, are essential processes in maintaining cellular homeostasis. As a result of their central role in human diseases, the proteins responsible for adding, removing, …
Epigenetic mechanisms for controlling gene expression through heritable modifications to DNA, RNA, and proteins, are essential processes in …
Childhood exposure to parental threatening behaviors and anxiety in emerging adulthood: Indirect effects of perceived stress.
Trent ES, Viana AG, Raines EM, Busch HEC, Silva K, Storch EA, Zvolensky MJ. Trent ES, et al. J Clin Psychol. 2023 Mar 27. doi: 10.1002/jclp.23516. Online ahead of print. J Clin Psychol. 2023. PMID: 36971223
Perceived stress-a subjective experience comprised of feelings of helplessness (being unable to cope or exert control) and poor self-efficacy (confidence in one's ability to manage stressors)-is one candidate mechanism. The present investigation examined the underlying rol …
Perceived stress-a subjective experience comprised of feelings of helplessness (being unable to cope or exert control) and poor self-efficac …
Evaluation of spiramycin for topical applications: a cell culture study.
Yagiz Aghayarov O, Bayar Muluk N, Vejselova Sezer C, Kutlu HM, Cingi C. Yagiz Aghayarov O, et al. Eur Rev Med Pharmacol Sci. 2023 Mar;27(2 Suppl):44-50. doi: 10.26355/eurrev_202303_31701. Eur Rev Med Pharmacol Sci. 2023. PMID: 36971220
OBJECTIVE: Through a cell culture test, we analyzed the cytotoxic effects of topical spiramycin on NIH/3T3 fibroblast cells. MATERIALS AND METHODS: Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin was us …
OBJECTIVE: Through a cell culture test, we analyzed the cytotoxic effects of topical spiramycin on NIH/3T3 fibroblast cells. MATERIAL …
Bromelain: a candidate to enhance wound healing after endonasal surgeries.
Esen E, Bayar Muluk N, Vejselova Sezer C, Kutlu HM, Cingi C. Esen E, et al. Eur Rev Med Pharmacol Sci. 2023 Mar;27(2 Suppl):33-38. doi: 10.26355/eurrev_202303_31699. Eur Rev Med Pharmacol Sci. 2023. PMID: 36971218
OBJECTIVE: In the present study, we investigated the topical bromelain's cytotoxic effects on mouse fibroblast NIH/3T3 cells via cell culture study. MATERIALS AND METHODS: In this cell culture study, Dulbecco's Modified Eagle Medium (DMEM) with fetal bovine s …
OBJECTIVE: In the present study, we investigated the topical bromelain's cytotoxic effects on mouse fibroblast NIH/3T3 cells v …
Efficacy and toxicity of anise oil as a potential topical wound healer: a cell culture study.
Sungur I, Bayar Muluk N, Vejselova Sezer C, Kutlu HM, Cingi C. Sungur I, et al. Eur Rev Med Pharmacol Sci. 2023 Mar;27(2 Suppl):14-20. doi: 10.26355/eurrev_202303_31696. Eur Rev Med Pharmacol Sci. 2023. PMID: 36971216
OBJECTIVE: We studied the cytotoxic effects of topical anise oil on NIH/3T3 fibroblast cells using a cell culture assay. MATERIALS AND METHODS: NIH/3T3 fibroblast cells were grown in Dulbecco's Modified Eagle Medium (DMEM) supplemented with fetal bovine serum …
OBJECTIVE: We studied the cytotoxic effects of topical anise oil on NIH/3T3 fibroblast cells using a cell culture assay. MATERIALS AN …
Insulin-like growth factor-2 is a promising candidate for the treatment and prevention of Alzheimer's disease.
Fitzgerald GS, Chuchta TG, McNay EC. Fitzgerald GS, et al. CNS Neurosci Ther. 2023 Mar 27. doi: 10.1111/cns.14160. Online ahead of print. CNS Neurosci Ther. 2023. PMID: 36971212 Review.
Alzheimer's disease (AD) is the most common form of dementia. Current AD treatments slow the rate of cognitive decline, but do not restore lost function. ...
Alzheimer's disease (AD) is the most common form of dementia. Current AD treatments slow the rate of cognitive decline, but do not re …
DNA supercoiling-induced shapes alter minicircle hydrodynamic properties.
Waszkiewicz R, Ranasinghe M, Fogg JM, Catanese DJ, Ekiel-Jeżewska ML, Lisicki M, Demeler B, Zechiedrich L, Szymczak P. Waszkiewicz R, et al. Nucleic Acids Res. 2023 Mar 27:gkad183. doi: 10.1093/nar/gkad183. Online ahead of print. Nucleic Acids Res. 2023. PMID: 36971110
Understanding community- and system-capacity change over time: A close look at changing social capital in Evidence2Success communities.
Chilenski SM, Gayles J, Luneke A, Lew D, Villarruel F, Penilla ML, Henderson C, Wilson H, Gary L. Chilenski SM, et al. J Community Psychol. 2023 Mar 27. doi: 10.1002/jcop.23034. Online ahead of print. J Community Psychol. 2023. PMID: 36971011
Evidence in majority White and low-population areas suggest that community prevention systems can create social capital that is needed to support high-quality implementation and sustainability of evidence-based programs. ...Community Board members reported social ca …
Evidence in majority White and low-population areas suggest that community prevention systems can create social capital that is neede …
[The hemostasis effect and cell compatibility of a chitosan-calcium alginate-laponite nanosheet composite membrane: in vitro and in vivo evaluation].
Wu J, Zou DH, Zhang ZY. Wu J, et al. Shanghai Kou Qiang Yi Xue. 2022 Dec;31(6):569-575. Shanghai Kou Qiang Yi Xue. 2022. PMID: 36970790 Chinese.
Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation. Cytotoxicity tests were quantified through co-culturing NIH/3T3 cells with chitosan-calcium alginate extract, composite hemostatic membra …
Clotting time of composite membrane, medical gauze and Chitin dressing in vitro was measured by the plate method for blood coagulation. Cyto …
Novel Paired Normal Prostate and Prostate Cancer Model Cell Systems Derived from African American Patients.
Jung M, Kowalczyk K, Hankins R, Bandi G, Kallakury B, Carrasquilla MA, Banerjee PP, Grindrod S, Dritschilo A. Jung M, et al. Cancer Res Commun. 2022 Dec 13;2(12):1617-1625. doi: 10.1158/2767-9764.CRC-22-0203. eCollection 2022 Dec. Cancer Res Commun. 2022. PMID: 36970725 Free PMC article.
African American (AA) men are at greater risk for developing prostate cancer, and experience higher mortality rates, as compared with Caucasian American men. However, mechanistic studies to understand this health disparity have been limited by the lack of relevant in vitro …
African American (AA) men are at greater risk for developing prostate cancer, and experience higher mortality rates, as compared with Caucas …
Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice.
Saeki K, Qiu W, Friedman RA, Pan S, Lu J, Ichimiya S, Chio IIC, Shawber CJ, Kitajewski J, Hu J, Su GH. Saeki K, et al. Cancer Res Commun. 2022 Dec 12;2(12):1601-1616. doi: 10.1158/2767-9764.CRC-22-0106. eCollection 2022 Dec. Cancer Res Commun. 2022. PMID: 36970723 Free PMC article.
Impact of specialty on the self-reported practice of using oral antibiotic therapy for definitive treatment of bloodstream infections.
Marcelin JR, Keintz MR, Ma J, Van Schooneveld TC, Alexander BT, Bergman SJ, Miller MM, Stohs EJ. Marcelin JR, et al. Antimicrob Steward Healthc Epidemiol. 2023 Mar 9;3(1):e48. doi: 10.1017/ash.2023.132. eCollection 2023. Antimicrob Steward Healthc Epidemiol. 2023. PMID: 36970426 Free PMC article.
METHODS: An open-access, web-based survey was distributed to clinicians at a Midwestern academic medical center using e-mail and to clinicians outside the medical center using social media. Respondents answered questions regarding confidence prescribing OAT for BSI in diff …
METHODS: An open-access, web-based survey was distributed to clinicians at a Midwestern academic medical center using e-mail and to clinicia …
Impacts of recreational cannabis legalization on use and harms: A narrative review of sex/gender differences.
Matheson J, Le Foll B. Matheson J, et al. Front Psychiatry. 2023 Mar 10;14:1127660. doi: 10.3389/fpsyt.2023.1127660. eCollection 2023. Front Psychiatry. 2023. PMID: 36970279 Free PMC article. Review.
Understanding the who, why, and when of this likely increase in cannabis-attributable harms is thus an important public health priority. Both sex and gender contribute to variability in the use, effects, and harms of cannabis and thus sex/gender considerations are importan …
Understanding the who, why, and when of this likely increase in cannabis-attributable harms is thus an important public health priori …
Symptoms of post-traumatic stress disorder in parents of preterm newborns: A systematic review of interventions and prevention strategies.
Laccetta G, Di Chiara M, De Nardo MC, Terrin G. Laccetta G, et al. Front Psychiatry. 2023 Mar 8;14:998995. doi: 10.3389/fpsyt.2023.998995. eCollection 2023. Front Psychiatry. 2023. PMID: 36970259 Free PMC article. Review.
The quality assessment was performed according to the criteria from the RoB-2 and the "NIH Quality Assessment Tool for Before-After studies." RESULTS: Sixteen thousand six hundred twenty-eight records were identified; finally, 15 articles (1,009 mothers, 44 fathers of infa …
The quality assessment was performed according to the criteria from the RoB-2 and the "NIH Quality Assessment Tool for Before-After s …
Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases.
Riek HC, Brien DC, Coe BC, Huang J, Perkins JE, Yep R, McLaughlin PM, Orange JB, Peltsch AJ, Roberts AC, Binns MA, Lou W, Abrahao A, Arnott SR, Beaton D, Black SE, Dowlatshahi D, Finger E, Fischer CE, Frank AR, Grimes DA, Kumar S, Lang AE, Lawrence-Dewar JM, Mandzia JL, Marras C, Masellis M, Pasternak SH, Pollock BG, Rajji TK, Sahlas DJ, Saposnik G, Seitz DP, Shoesmith C, Steeves TDL, Strother SC, Sunderland KM, Swartz RH, Tan B, Tang-Wai DF, Tartaglia MC, Turnbull J, Zinman L, Munoz DP; ONDRI Investigators. Riek HC, et al. Brain Commun. 2023 Mar 2;5(2):fcad049. doi: 10.1093/braincomms/fcad049. eCollection 2023. Brain Commun. 2023. PMID: 36970045 Free PMC article.
We remediate these issues by characterizing 12 behavioural parameters, selected to robustly describe saccade behaviour, derived from an interleaved prosaccade and antisaccade task in a large cross-sectional data set comprising five disease cohorts (Alzheimer's disease/mild …
We remediate these issues by characterizing 12 behavioural parameters, selected to robustly describe saccade behaviour, derived from an inte …
Under-Representation of Racial Groups in Genomics Studies of Gastroenteropancreatic Neuroendocrine Neoplasms.
Herring BR, Bonner A, Guenter RE, Vickers S, Yates C, Lee G, Dhall D, Chen H, Rose JB. Herring BR, et al. Cancer Res Commun. 2022 Oct 12;2(10):1162-1173. doi: 10.1158/2767-9764.CRC-22-0093. eCollection 2022 Oct. Cancer Res Commun. 2022. PMID: 36969744 Free PMC article.
Manuscripts analyzing DNA, RNA, or DNA methylation in GEP-NENs were queried using PUBMED and EMBASE. NIH race/ethnicity term frequency was then determined by Natural Language Processing, followed by manual evaluation of tumor types and subjects by racial group. ...
Manuscripts analyzing DNA, RNA, or DNA methylation in GEP-NENs were queried using PUBMED and EMBASE. NIH race/ethnicity term frequenc …
Advance Care Planning and Health-Related Quality of Life in Huntington Disease: Results from a Multicenter National Study.
Sokol LL, Troost JP, Bega D, Kluger BM, Prigerson HG, Nance M, Frank S, Perlmutter JS, Dayalu P, Cella D, Carlozzi NE. Sokol LL, et al. Palliat Med Rep. 2023 Mar 22;4(1):79-88. doi: 10.1089/pmr.2022.0034. eCollection 2023. Palliat Med Rep. 2023. PMID: 36969738 Free PMC article.
OBJECTIVE: With Huntington disease (HD), a fatal neurodegenerative disease where the prevalence of suicidal thoughts and behavior (STB) remains elevated as compared to other neurological disorders, it is unknown whether STB and health-related quality of life (HRQoL) affect …
OBJECTIVE: With Huntington disease (HD), a fatal neurodegenerative disease where the prevalence of suicidal thoughts and behavior (STB) rema …
Effect of pregnancy versus postpartum maternal isoniazid preventive therapy on infant growth in HIV-exposed uninfected infants: a post-hoc analysis of the TB APPRISE trial.
Cherkos AS, LaCourse SM, Enquobahrie DA, Richardson BA, Bradford S, Montepiedra G, Mmbaga BT, Mbengeranwa T, Masheto G, Jean-Phillippe P, Chakhtoura N, Theron G, Weinberg A, Cassim H, Raesi MS, Jean E, Wabwire D, Nematadzira T, Stranix-Chibanda L, Hesseling AC, Aurpibul L, Gupta A, John-Stewart G; IMPAACT P1078 TB APPRISE Study Team. Cherkos AS, et al. EClinicalMedicine. 2023 Mar 17;58:101912. doi: 10.1016/j.eclinm.2023.101912. eCollection 2023 Apr. EClinicalMedicine. 2023. PMID: 36969345 Free PMC article.
Factors adjusted in the final models include sex of infant, mother's baseline BMI, age in years, ART regimen, viral load, CD4 count, education, and household food insecurity. ...These data add to prior TB APPRISE data, suggesting that IPT during pregnancy impacts infant gr …
Factors adjusted in the final models include sex of infant, mother's baseline BMI, age in years, ART regimen, viral load, CD4 count, …
Pakistan's healthcare preparedness after the NIH warned of a new diphtheria strain and Covid-19 variation.
Muzzamil M, Naz S, Mumtaz H, Omair W. Muzzamil M, et al. J Taibah Univ Med Sci. 2023 Mar 12;18(5):1055-1057. doi: 10.1016/j.jtumed.2023.03.002. eCollection 2023 Oct. J Taibah Univ Med Sci. 2023. PMID: 36969319 Free PMC article.
Immunization is critically important because vaccine-preventable diseases pose a significant risk to the general population. Pakistan's authorities and government should take deliberate action to increase immunization rates. ...
Immunization is critically important because vaccine-preventable diseases pose a significant risk to the general population. Pakistan's
Case report: De novo SAMD9L truncation causes neonatal-onset autoinflammatory syndrome which was successfully treated with hematopoietic stem cell transplantation.
Caldirola MS, Seminario AG, Luna PC, Curciarello R, Docena GH, Fernandez Escobar N, Drelichman G, Gattorno M, de Jesus AA, Goldbach-Mansky R, Gaillard MI, Bezrodnik L. Caldirola MS, et al. Front Pediatr. 2023 Mar 10;11:1108207. doi: 10.3389/fped.2023.1108207. eCollection 2023. Front Pediatr. 2023. PMID: 36969289 Free PMC article.
Effect of postoperative systemic prednisolone on short-term and long-term outcomes in chronic rhinosinusitis with nasal polyps: A multi-centered randomized clinical trial.
Mueller SK, Wendler O, Mayr S, Traxdorf M, Hosemann W, Olze H, Steinhart H, Wiegand S, Teymoortash A, Kuehnel T, Hackenberg S, Hummel T, Ambrosch P, Fazel A, Schick B, Baenkler HW, Koch M, Buerner H, Mantsopoulos K, Grundtner P, Nocera A, Agaimy A, Bleier B, Iro H. Mueller SK, et al. Front Immunol. 2023 Mar 8;14:1075066. doi: 10.3389/fimmu.2023.1075066. eCollection 2023. Front Immunol. 2023. PMID: 36969262 Free PMC article. Clinical Trial.
MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression.
Schrörs B, Hos BJ, Yildiz IG, Löwer M, Lang F, Holtsträter C, Becker J, Vormehr M, Sahin U, Ossendorp F, Diken M. Schrörs B, et al. Front Immunol. 2023 Mar 8;14:1102282. doi: 10.3389/fimmu.2023.1102282. eCollection 2023. Front Immunol. 2023. PMID: 36969213 Free PMC article.
METHODS: Here, we re-sequenced exomes and transcriptomes of MC38 cells from two different sources, namely Kerafast (originating from NCI/NIH, MC38-K) and the Leiden University Medical Center cell line collection (MC38-L), comparing the cell lines on the genomic and transcr …
METHODS: Here, we re-sequenced exomes and transcriptomes of MC38 cells from two different sources, namely Kerafast (originating from NCI/ …
The Minderoo-Monaco Commission on Plastics and Human Health.
Landrigan PJ, Raps H, Cropper M, Bald C, Brunner M, Canonizado EM, Charles D, Chiles TC, Donohue MJ, Enck J, Fenichel P, Fleming LE, Ferrier-Pages C, Fordham R, Gozt A, Griffin C, Hahn ME, Haryanto B, Hixson R, Ianelli H, James BD, Kumar P, Laborde A, Law KL, Martin K, Mu J, Mulders Y, Mustapha A, Niu J, Pahl S, Park Y, Pedrotti ML, Pitt JA, Ruchirawat M, Seewoo BJ, Spring M, Stegeman JJ, Suk W, Symeonides C, Takada H, Thompson RC, Vicini A, Wang Z, Whitman E, Wirth D, Wolff M, Yousuf AK, Dunlop S. Landrigan PJ, et al. Ann Glob Health. 2023 Mar 21;89(1):23. doi: 10.5334/aogh.4056. eCollection 2023. Ann Glob Health. 2023. PMID: 36969097 Free PMC article. Review.
GOALS: The goals of this Minderoo-Monaco Commission on Plastics and Human Health are to comprehensively examine plastics' impacts across their life cycle on: (1) human health and well-being; (2) the global environment, especially the ocean; (3) the eco …
GOALS: The goals of this Minderoo-Monaco Commission on Plastics and Human Health are to comprehensively examine plastics' impa …
Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer.
Tucker JB, Bonema SC, García-Varela R, Denu RA, Hu Y, McGregor SM, Burkard ME, Weaver BA. Tucker JB, et al. Cancer Res Commun. 2023 Jan 12;3(1):54-65. doi: 10.1158/2767-9764.CRC-22-0302. eCollection 2023 Jan. Cancer Res Commun. 2023. PMID: 36968230 Free PMC article.
Chromosomal instability (CIN), the persistent reshuffling of chromosomes during mitosis, is a hallmark of human cancers that contributes to tumor heterogeneity and has been implicated in driving metastasis and altering responses to therapy. ...
Chromosomal instability (CIN), the persistent reshuffling of chromosomes during mitosis, is a hallmark of human cancers that contribu …
Inhibiting IGF1R-mediated Survival Signaling in Head and Neck Cancer with the Peptidomimetic SSTNIGF1R.
Stueven NA, Beauvais DM, Hu R, Kimple RJ, Rapraeger AC. Stueven NA, et al. Cancer Res Commun. 2023 Jan 19;3(1):97-108. doi: 10.1158/2767-9764.CRC-22-0274. eCollection 2023 Jan. Cancer Res Commun. 2023. PMID: 36968227 Free PMC article.
In vivo, SSTN(IGF1R) reduced the growth of patient-derived HNSCC tumors in immunodeficient mice by 85%-95%. IGF1R's assimilation into the matrix receptor complex, which is detected in these tumors using the proximity ligation assay (PLA), is quantitatively disrupted by SST …
In vivo, SSTN(IGF1R) reduced the growth of patient-derived HNSCC tumors in immunodeficient mice by 85%-95%. IGF1R's assimilation into …
Inclusion of 4-1BB Costimulation Enhances Selectivity and Functionality of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells.
Starr R, Aguilar B, Gumber D, Maker M, Huard S, Wang D, Chang WC, Brito A, Chiu V, Ostberg JR, Badie B, Forman SJ, Alizadeh D, Wang LD, Brown CE. Starr R, et al. Cancer Res Commun. 2023 Jan 17;3(1):66-79. doi: 10.1158/2767-9764.CRC-22-0185. eCollection 2023 Jan. Cancer Res Commun. 2023. PMID: 36968221 Free PMC article.
In vitro coculture assays at high tumor burden establish that second-generation IL13-BBzeta or IL13-28zeta outperform first-generation IL13zeta and third-generation IL13-28BBzeta CAR designs, with IL13-BBzeta providing superior CAR proliferation and in vivo antitumor potency in …
In vitro coculture assays at high tumor burden establish that second-generation IL13-BBzeta or IL13-28zeta outperform first-generation IL13z …
Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Zhan J, Lin D, Watson N, Esser L, Tang WK, Zhang A, Liu X, Hassan R, Gleinich A, Shajahan A, Azadi P, Pastan I, Xia D. Zhan J, et al. Cancer Res Commun. 2023 Feb 1;3(2):175-191. doi: 10.1158/2767-9764.CRC-22-0306. eCollection 2023 Feb. Cancer Res Commun. 2023. PMID: 36968141 Free PMC article.
The tumor-associated antigen mesothelin is expressed at high levels on the cell surface of many human cancers, while its expression in normal tissues is limited. ...
The tumor-associated antigen mesothelin is expressed at high levels on the cell surface of many human cancers, while its expression i …
Multicenter Phase II Trial of the PARP Inhibitor Olaparib in Recurrent IDH1- and IDH2-mutant Glioma.
Fanucci K, Pilat MJ, Shyr D, Shyr Y, Boerner S, Li J, Durecki D, Drappatz J, Puduvalli V, Lieberman FS, Gonzalez J, Giglio P, Ivy SP, Bindra RS, Omuro A, LoRusso P. Fanucci K, et al. Cancer Res Commun. 2023 Feb 2;3(2):192-201. doi: 10.1158/2767-9764.CRC-22-0436. eCollection 2023 Feb. Cancer Res Commun. 2023. PMID: 36968138 Free PMC article.
However, prolonged SD was observed in patients with grades 2 and 3 histologies, suggesting olaparib monotherapy could be of clinical benefit in select populations. Grade 4 tumors per 2021 World Health Organization classification defined by histology or CDKN2A alteration de …
However, prolonged SD was observed in patients with grades 2 and 3 histologies, suggesting olaparib monotherapy could be of clinical benefit …
The mouse models of human cancer database (MMHCdb).
Begley DA, Krupke DM, Sundberg JP, Jocoy EL, Richardson JE, Neuhauser SB, Bult CJ. Begley DA, et al. Dis Model Mech. 2023 Mar 27:dmm.050001. doi: 10.1242/dmm.050001. Online ahead of print. Dis Model Mech. 2023. PMID: 36967676
Although thousands of mouse models have been generated, compiling and aggregating relevant data and knowledge about these models is hampered by a general lack of compliance in the published literature with nomenclature and annotation standards for genes, alleles, mouse strains, a …
Although thousands of mouse models have been generated, compiling and aggregating relevant data and knowledge about these models is hampered …
Integrin β3 regulates apical dendritic morphology of pyramidal neurons throughout hippocampal CA3.
Handwerk CJ, Denzler CJ, Kalinowski AR, Cook HN, Rodriguez HV, Bland KM, Brett CA, Swinehart BD, Vinson EC, Vidal GS. Handwerk CJ, et al. Hippocampus. 2023 Mar 26. doi: 10.1002/hipo.23530. Online ahead of print. Hippocampus. 2023. PMID: 36967540
We fully reconstructed the apical dendrite of each neuron and determined each neuron's precise location along the dorsoventral, proximodistal, and radial axes of the stratum pyramidale. ...
We fully reconstructed the apical dendrite of each neuron and determined each neuron's precise location along the dorsoventral, proxi …
ElasticBLAST: accelerating sequence search via cloud computing.
Camacho C, Boratyn GM, Joukov V, Vera Alvarez R, Madden TL. Camacho C, et al. BMC Bioinformatics. 2023 Mar 26;24(1):117. doi: 10.1186/s12859-023-05245-9. BMC Bioinformatics. 2023. PMID: 36967390 Free PMC article.
It uses cloud native tools for orchestration and can request discounted instances, lowering cloud costs for users. It is supported on Amazon Web Services and Google Cloud Platform. It can search BLAST databases that are user provided or from the National Center for …
It uses cloud native tools for orchestration and can request discounted instances, lowering cloud costs for users. It is supported on Amazon …
Visualization of cardiac uptake of bone marrow mesenchymal stem cell-derived extracellular vesicles after intramyocardial or intravenous injection in murine myocardial infarction.
Xu CM, Sabe SA, Brinck-Teixeira R, Sabra M, Sellke FW, Abid MR. Xu CM, et al. Physiol Rep. 2023 Mar;11(6):e15568. doi: 10.14814/phy2.15568. Physiol Rep. 2023. PMID: 36967241 Free PMC article.
In animal models, human bone marrow mesenchymal stem cell-derived extracellular vesicles (MSC-EV) have been found to have beneficial effects in cardiovascular disease, but only when administered via intramyocardial injection. ...We hypothesized that intramyocardial injecti …
In animal models, human bone marrow mesenchymal stem cell-derived extracellular vesicles (MSC-EV) have been found to have beneficial …
Claimed-based frailty index in Japanese older adults: a cohort study using LIFE Study.
Nakatsuka K, Ono R, Murata S, Akisue T, Fukuda H. Nakatsuka K, et al. J Epidemiol. 2023 Mar 25. doi: 10.2188/jea.JE20220310. Online ahead of print. J Epidemiol. 2023. PMID: 36967119
BACKGROUNDS: We aimed to assess whether the U.S. developed claimed-based frailty index (CFI) can be implemented in Japanese older adults using claim data. ...
BACKGROUNDS: We aimed to assess whether the U.S. developed claimed-based frailty index (CFI) can be implemented in Japanese ol …
Recent advances in mass spectrometry-based computational metabolomics.
Ebbels TMD, van der Hooft JJJ, Chatelaine H, Broeckling C, Zamboni N, Hassoun S, Mathé EA. Ebbels TMD, et al. Curr Opin Chem Biol. 2023 Mar 24;74:102288. doi: 10.1016/j.cbpa.2023.102288. Online ahead of print. Curr Opin Chem Biol. 2023. PMID: 36966702 Review.
The confluence of machine learning and multiscale simulations.
Bhatia H, Aydin F, Carpenter TS, Lightstone FC, Bremer PT, Ingólfsson HI, Nissley DV, Streitz FH. Bhatia H, et al. Curr Opin Struct Biol. 2023 Mar 23;80:102569. doi: 10.1016/j.sbi.2023.102569. Online ahead of print. Curr Opin Struct Biol. 2023. PMID: 36966691 Review.
Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV.
Kolossváry M, deFilippi C, McCallum S, Fitch KV, Diggs MR, Fulda ES, Ribaudo HJ, Fichtenbaum CJ, Aberg JA, Malvestutto CD, Currier JS, Casado JL, Gutiérrez F, Sereti I, Douglas PS, Zanni MV, Grinspoon SK. Kolossváry M, et al. EBioMedicine. 2023 Mar 24;90:104538. doi: 10.1016/j.ebiom.2023.104538. Online ahead of print. EBioMedicine. 2023. PMID: 36966617 Free PMC article.
Further we identified key granzyme proteins associated with future COVID-19 in PWH. FUNDING: This study is supported through NIH grants U01HL123336, U01HL123336-06 and 3U01HL12336-06S3, to the clinical coordinating center, and U01HL123339, to the data coordinating center a …
Further we identified key granzyme proteins associated with future COVID-19 in PWH. FUNDING: This study is supported through NIH gran …
Suitability of Goal Attainment Scaling in Older Adult Populations with Neurodegenerative Disease Experiencing Cognitive Impairment: A Systematic Review and Meta-Analysis.
Fegter O, Santos H, Rademaker A, Roberts AC, Rogalski E. Fegter O, et al. Gerontology. 2023 Mar 24. doi: 10.1159/000529984. Online ahead of print. Gerontology. 2023. PMID: 36966524
A summary measure of responsiveness (post-intervention minus pre-intervention mean GAS T-score) was compared across eligible studies using a random-effects meta-analysis. Risk of bias in included studies was assessed using the NIH Quality Assessment Tool for Before-After ( …
A summary measure of responsiveness (post-intervention minus pre-intervention mean GAS T-score) was compared across eligible studies using a …
Biophysical model of muscle spindle encoding.
Housley SN, Powers RK, Nardelli P, Lee S, Blum K, Bewick GS, Banks RW, Cope TC. Housley SN, et al. Exp Physiol. 2023 Mar 26. doi: 10.1113/EP091099. Online ahead of print. Exp Physiol. 2023. PMID: 36966478 Review.
Outstanding outcomes with two low intensity regimens in children with low-risk B-ALL: a report from COG AALL0932.
Schore RJ, Angiolillo AL, Kairalla JA, Devidas M, Rabin KR, Zweidler-McKay P, Borowitz MJ, Wood B, Carroll AJ, Heerema NA, Relling MV, Hitzler J, Kadan-Lottick NS, Maloney K, Wang C, Carroll WL, Winick NJ, Raetz EA, Loh ML, Hunger SP. Schore RJ, et al. Leukemia. 2023 Mar 25. doi: 10.1038/s41375-023-01870-8. Online ahead of print. Leukemia. 2023. PMID: 36966262 No abstract available.
TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia.
Winfree RL, Seto M, Dumitrescu L, Menon V, De Jager P, Wang Y, Schneider J, Bennett DA, Jefferson AL, Hohman TJ. Winfree RL, et al. Acta Neuropathol. 2023 Mar 25. doi: 10.1007/s00401-023-02564-2. Online ahead of print. Acta Neuropathol. 2023. PMID: 36966244
TREM2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of Alzheimer's disease (amyloid-beta, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, athero …
TREM2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to co …
Cancer in Costello syndrome: a systematic review and meta-analysis.
Astiazaran-Symonds E, Ney GM, Higgs C, Oba L, Srivastava R, Livinski AA, Rosenberg PS, Stewart DR. Astiazaran-Symonds E, et al. Br J Cancer. 2023 Mar 25. doi: 10.1038/s41416-023-02229-7. Online ahead of print. Br J Cancer. 2023. PMID: 36966234
SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation.
Sanchez L, Epps J, Wall S, McQueen C, Pearson SJ, Scribner K, Wellberg EA, Giles ED, Rijnkels M, Porter WW. Sanchez L, et al. Cell Death Differ. 2023 Mar 25. doi: 10.1038/s41418-023-01146-9. Online ahead of print. Cell Death Differ. 2023. PMID: 36966227
The functionally differentiated mammary gland adapts to extreme levels of stress from increased demand for energy by activating specific protective mechanisms to support neonatal health. Here, we identify the breast tumor suppressor gene, single-minded 2 s (SIM2s) a …
The functionally differentiated mammary gland adapts to extreme levels of stress from increased demand for energy by activating specific pro …
Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures.
Lee S, Deshpande SS, Merricks EM, Schlafly E, Goodman R, McKhann GM, Eskandar EN, Madsen JR, Cash SS, van Putten MJAM, Schevon CA, van Drongelen W. Lee S, et al. Commun Biol. 2023 Mar 25;6(1):317. doi: 10.1038/s42003-023-04696-3. Commun Biol. 2023. PMID: 36966217 Free PMC article.
We show that this theoretical result is observed in a real-world system by characterizing the spike-LFP relationship using microelectrode array (MEA) recordings of human focal seizures. To do this, we present a approach, termed the spatiotemporal spike-centered average (st …
We show that this theoretical result is observed in a real-world system by characterizing the spike-LFP relationship using microelectrode ar …
Phosphate induces inflammation and exacerbates injury from cigarette smoke in the bronchial epithelium.
Bollenbecker S, Heitman K, Czaya B, Easter M, Hirsch MJ, Vang S, Harris E, Helton ES, Barnes JW, Faul C, Krick S. Bollenbecker S, et al. Sci Rep. 2023 Mar 25;13(1):4898. doi: 10.1038/s41598-023-32053-1. Sci Rep. 2023. PMID: 36966182 Free PMC article.
Our in vitro studies point towards a similar increase of phosphate-induced inflammatory markers in human bronchial epithelial cells. FGF23 stimulation alone does not induce a proinflammatory response in the non-COPD bronchial epithelium and phosphate does not cause endogen …
Our in vitro studies point towards a similar increase of phosphate-induced inflammatory markers in human bronchial epithelial cells. …
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells.
Chibly AM, Patel VN, Aure MH, Pasquale MC; NIDCD/NIDCR Genomics and Computational Biology Core; Martin GE, Ghannam M, Andrade J, Denegre NG, Simpson C, Goldstein DP, Liu FF, Lombaert IMA, Hoffman MP. Chibly AM, et al. NPJ Regen Med. 2023 Mar 25;8(1):17. doi: 10.1038/s41536-023-00290-7. NPJ Regen Med. 2023. PMID: 36966175 Free PMC article.
The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin signaling is highly disrupted post-radiation. ...Using two ex vivo models, we show that nerve growth f …
The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human sal …
Deep-Learning-Based Whole-Lung and Lung-Lesion Quantification Despite Inconsistent Ground Truth: Application to Computerized Tomography in SARS-CoV-2 Nonhuman Primate Models.
Reza SMS, Chu WT, Homayounieh F, Blain M, Firouzabadi FD, Anari PY, Lee JH, Worwa G, Finch CL, Kuhn JH, Malayeri A, Crozier I, Wood BJ, Feuerstein IM, Solomon J. Reza SMS, et al. Acad Radiol. 2023 Feb 27:S1076-6332(23)00101-0. doi: 10.1016/j.acra.2023.02.027. Online ahead of print. Acad Radiol. 2023. PMID: 36966070 Free PMC article.
The application of deep-learning data-science tools has been less well-evaluated in the preclinical setting, including in nonhuman primate (NHP) models of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection/COVID-19, in which the translation of human-der …
The application of deep-learning data-science tools has been less well-evaluated in the preclinical setting, including in nonhuman primate ( …
The Problem of Pain in the United States: A Population-Based Characterization of Biopsychosocial Correlates of High Impact Chronic Pain using the National Health Interview Survey.
Falasinnu T, Hossain MB, Weber KA 2nd, Helmick CG, Karim ME, Mackey S. Falasinnu T, et al. J Pain. 2023 Mar 23:S1526-5900(23)00368-1. doi: 10.1016/j.jpain.2023.03.008. Online ahead of print. J Pain. 2023. PMID: 36965649 Free article.
The most important factors associated with HICP were those related to underlying ill-health (arthritis and rheumatism, hospitalizations, and emergency department visits) and poor psychological well-being. ...PERSPECTIVE: Our study developed models to identify factor …
The most important factors associated with HICP were those related to underlying ill-health (arthritis and rheumatism, hospitalizatio …
A Snapshot on Oral and Maxillofacial Surgery Resident Scholarly Activity: Can We Do Better?
Nguyen RM, Cimba MJ, Lee KC, Panchal N, Schlieve T. Nguyen RM, et al. J Oral Maxillofac Surg. 2023 Mar 7:S0278-2391(23)00214-8. doi: 10.1016/j.joms.2023.02.017. Online ahead of print. J Oral Maxillofac Surg. 2023. PMID: 36965516
Resident names were searched in PubMed (https://pubmed.ncbi.nlm.nih.gov/) to identify peer-reviewed publications. Postgraduate year (PGY), program name, and total publication count during residency were recorded for each resident. ...
Resident names were searched in PubMed (https://pubmed.ncbi.nlm.nih.gov/) to identify peer-reviewed publications. Postgraduate year ( …
Bi-allelic SNAPC4 variants dysregulate global alternative splicing and lead to neuroregression and progressive spastic paraparesis.
Frost FG, Morimoto M, Sharma P, Ruaud L, Belnap N, Calame DG, Uchiyama Y, Matsumoto N, Oud MM, Ferreira EA, Narayanan V, Rangasamy S, Huentelman M, Emrick LT, Sato-Shirai I, Kumada S, Wolf NI, Steinbach PJ, Huang Y; Undiagnosed Diseases Network; Pusey BN, Passemard S, Levy J, Drunat S, Vincent M, Guet A, Agolini E, Novelli A, Digilio MC, Rosenfeld JA, Murphy JL, Lupski JR, Vezina G, Macnamara EF, Adams DR, Acosta MT, Tifft CJ, Gahl WA, Malicdan MCV. Frost FG, et al. Am J Hum Genet. 2023 Mar 22:S0002-9297(23)00085-X. doi: 10.1016/j.ajhg.2023.03.001. Online ahead of print. Am J Hum Genet. 2023. PMID: 36965478
The vast majority of human genes encode multiple isoforms through alternative splicing, and the temporal and spatial regulation of those isoforms is critical for organismal development and function. ...
The vast majority of human genes encode multiple isoforms through alternative splicing, and the temporal and spatial regulation of th …
Effects of pictorial warnings on parents' purchases and perceptions of sugar-sweetened beverage categories.
D'Angelo Campos A, Taillie LS, Vatavuk-Serrati G, Grummon AH, Higgins ICA, Hall MG. D'Angelo Campos A, et al. Pediatr Obes. 2023 Mar 25:e13030. doi: 10.1111/ijpo.13030. Online ahead of print. Pediatr Obes. 2023. PMID: 36965067
RESULTS: Responses from parents in the control arm suggest underlying perceptions of flavoured milk (2.8 on scale ranging from 1 to 5), flavoured water (2.6), and fruit-flavoured drinks (2.5) as the most healthful SSB categories. Compared to the control, pictorial warnings …
RESULTS: Responses from parents in the control arm suggest underlying perceptions of flavoured milk (2.8 on scale ranging from 1 to 5), flav …
The nasal septum and midfacial growth.
Baldwin MC, Zarudnaya D, Liu ZJ, Herring SW. Baldwin MC, et al. Anat Rec (Hoboken). 2023 Mar 25. doi: 10.1002/ar.25214. Online ahead of print. Anat Rec (Hoboken). 2023. PMID: 36965023
Revisiting a Telencephalic Extent of the Ascending Reticular Activating System.
Miyawaki EK, Bhattacharyya S, Torre M. Miyawaki EK, et al. Cell Mol Neurobiol. 2023 Mar 25. doi: 10.1007/s10571-023-01339-3. Online ahead of print. Cell Mol Neurobiol. 2023. PMID: 36964874 Review.
We review a generally undercited literature that describes nucleus basalis of Meynert, located within the substantia innominata of the ventrobasal forebrain, as a telencephalic extension of the ascending reticular activating formation. Although that formation's precise ana …
We review a generally undercited literature that describes nucleus basalis of Meynert, located within the substantia innominata of the ventr …
Intravascular laser irradiation of blood (ILIB) used to treat lung diseases: a short critical review.
Schapochnik A, Alonso PT, de Souza V, Rodrigues V, Quintela K, Cruz MDP, Ferreira CM, Cecatto RB, Rodrigues MFSD, Hamblin MR, Lino-Dos-Santos-Franco A. Schapochnik A, et al. Lasers Med Sci. 2023 Mar 25;38(1):93. doi: 10.1007/s10103-023-03750-0. Lasers Med Sci. 2023. PMID: 36964849 Free PMC article. Review.
In conclusion, all studies showed promising effects of ILIB in both animal and human studies. The studies did not discuss any disadvantages or contraindications. ...
In conclusion, all studies showed promising effects of ILIB in both animal and human studies. The studies did not discuss any disadva …
Hospital Designations and Their Impact on Guideline-Concordant Care and Survival in Pancreatic Cancer. Do They Matter?
Murimwa GZ, Karalis JD, Meier J, Yan J, Zhu H, Hester CA, Porembka MR, Wang SC, Mansour JC, Zeh HJ 3rd, Yopp AC, Polanco PM. Murimwa GZ, et al. Ann Surg Oncol. 2023 Mar 25. doi: 10.1245/s10434-023-13308-7. Online ahead of print. Ann Surg Oncol. 2023. PMID: 36964844
Univariable (UVA) and multivariable (MVA) logistic regression were used to assess associations with GCC [on the basis of National Comprehensive Cancer Network (NCCN) recommendations]. Cox regression analysis assessed survival. ...
Univariable (UVA) and multivariable (MVA) logistic regression were used to assess associations with GCC [on the basis of National Com …
Neurodevelopmental Consequences of Dietary Zinc Deficiency: A Status Report.
Ross MM, Hernandez-Espinosa DR, Aizenman E. Ross MM, et al. Biol Trace Elem Res. 2023 Mar 25. doi: 10.1007/s12011-023-03630-2. Online ahead of print. Biol Trace Elem Res. 2023. PMID: 36964812 Review.
Although severe dietary zinc deficiency is relatively uncommon in the United States, dietary zinc deficiency is a substantial public health concern in low- and middle-income countries. Zinc status may be a key determinant of neurodevelopmental processes. ...Animal models o …
Although severe dietary zinc deficiency is relatively uncommon in the United States, dietary zinc deficiency is a substantial public heal
Serial prophylactic exchange blood transfusion in pregnant women with sickle cell disease (TAPS-2): statistical and qualitative analysis plan for a randomised controlled feasibility trial.
Seed PT, Brien SB, Oakley LL, Robinson V, Sharif J, Thompson H, Joseph J, Oteng-Ntim E. Seed PT, et al. Trials. 2023 Mar 24;24(1):225. doi: 10.1186/s13063-023-07235-x. Trials. 2023. PMID: 36964626 Free PMC article. Clinical Trial.
METHODS AND DESIGN: TAPS2 is a randomised two-arm phase 2 feasibility trial with a nested qualitative study and health economic evaluation. Up to 50 pregnant women with SCD and a singleton pregnancy will be recruited and individually randomised to either SPEBT approximatel …
METHODS AND DESIGN: TAPS2 is a randomised two-arm phase 2 feasibility trial with a nested qualitative study and health economic evalu …
Study design to evaluate a web-intervention to prevent alcohol and cannabis-impaired driving and use among adolescents in driver education.
Osilla KC, D'Amico EJ, Smart R, Rodriguez A, Nameth K, Hummer J. Osilla KC, et al. Addict Sci Clin Pract. 2023 Mar 24;18(1):17. doi: 10.1186/s13722-023-00373-2. Addict Sci Clin Pract. 2023. PMID: 36964608 Free PMC article.
BACKGROUND: Alcohol and cannabis are the most commonly used substances among adolescents in the U.S. The consequences related to using both substances together are significantly higher relative to use of either substance alone. ...We will also explore whether variab …
BACKGROUND: Alcohol and cannabis are the most commonly used substances among adolescents in the U.S. The consequences related …
Therapeutic preference for Alzheimer's disease treatments: a discrete choice experiment with caregivers and neurologists.
Dranitsaris G, Zhang Q, Mu L, Weyrer C, Drysdale E, Neumann P, Atri A, Monfared AAT. Dranitsaris G, et al. Alzheimers Res Ther. 2023 Mar 24;15(1):60. doi: 10.1186/s13195-023-01207-8. Alzheimers Res Ther. 2023. PMID: 36964606 Free PMC article.
BACKGROUND: Alzheimer's disease (AD) is a major global health crisis in need of more effective therapies. ...
BACKGROUND: Alzheimer's disease (AD) is a major global health crisis in need of more effective therapies. ...
Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC.
Venkateswaran S, Somineni HK, Matthews JD, Kilaru V, Hyams JS, Denson LA, Kellamayer R, Gibson G, Cutler DJ, Conneely KN, Smith AK, Kugathasan S. Venkateswaran S, et al. Clin Epigenetics. 2023 Mar 24;15(1):50. doi: 10.1186/s13148-023-01462-4. Clin Epigenetics. 2023. PMID: 36964596 Free PMC article.
The association of employment status and unwanted job loss with maternal oral health experiences: findings from the pregnancy risk assessment monitoring system.
Testa A, Gimeno Ruiz de Porras D. Testa A, et al. BMC Oral Health. 2023 Mar 24;23(1):168. doi: 10.1186/s12903-023-02869-4. BMC Oral Health. 2023. PMID: 36964511 Free PMC article.
BACKGROUND: Oral health is an essential component of a healthy pregnancy. While most women work full-time while pregnant, research has overlooked the impact of occupational status and job loss on oral health experiences during pregnancy. ...CONCLUSION: Experiencing …
BACKGROUND: Oral health is an essential component of a healthy pregnancy. While most women work full-time while pregnant, research ha …
Psychometric Evaluation of the Abbreviated Multidimensional Acculturation Scale (AMAS) in a Treatment-Seeking Sample of First-Generation Immigrant Caregivers.
Urcuyo AE, Conroy K, Sanchez AL, Silva K, Furr JM, Bagner DM, Comer JS. Urcuyo AE, et al. Child Psychiatry Hum Dev. 2023 Mar 24. doi: 10.1007/s10578-023-01525-w. Online ahead of print. Child Psychiatry Hum Dev. 2023. PMID: 36964458
The unique needs of first-generation immigrants and their families have not been prioritized in mental healthcare. Cultural tailoring of child services requires valid, reliable, and efficient assessments of family cultural identity. ...We offer the first AMAS psychometric …
The unique needs of first-generation immigrants and their families have not been prioritized in mental healthcare. Cultural tailoring of chi …
Long-Term Prospects for Telemedicine in Opioid Use Disorder (OUD) Treatment: Results from a Longitudinal Survey of OUD Clinicians.
Huskamp HA, Riedel L, Campa I, Busch AB, Rose S, Mehrotra A, Uscher-Pines L. Huskamp HA, et al. J Gen Intern Med. 2023 Mar 24:1-8. doi: 10.1007/s11606-023-08165-9. Online ahead of print. J Gen Intern Med. 2023. PMID: 36964424 Free PMC article.
DESIGN: Longitudinal survey (wave 1, December 2020; wave 2, March 2022). SUBJECTS: National sample of 425 clinicians who treat OUD. MAIN MEASURES: Self-reported proportion of OUD visits delivered via telemedicine (actual vs. preferred), comfort in using video visits for OU …
DESIGN: Longitudinal survey (wave 1, December 2020; wave 2, March 2022). SUBJECTS: National sample of 425 clinicians who treat OUD. M …
Development of a New Measure of Housing Security: The REDD-CAT Housing Security Measure.
Carlozzi NE, Kallen MA, Troost JP, Miner JA, Bragg A, Martin-Howard J, De La Cruz B, Moldovan I, Jack BW, Mitchell S. Carlozzi NE, et al. J Gen Intern Med. 2023 Mar 24:1-15. doi: 10.1007/s11606-023-08147-x. Online ahead of print. J Gen Intern Med. 2023. PMID: 36964423 Free PMC article.
BACKGROUND: Housing security is a key social determinant of behavior related to health outcomes. OBJECTIVE: The purpose of this study was to develop a new patient-reported outcome measure that evaluates aspects of housing security for use in the Re-Engineered Discha …
BACKGROUND: Housing security is a key social determinant of behavior related to health outcomes. OBJECTIVE: The purpose of thi …
An operant social self-administration and choice model in mice.
Ramsey LA, Holloman FM, Lee SS, Venniro M. Ramsey LA, et al. Nat Protoc. 2023 Mar 24. doi: 10.1038/s41596-023-00813-y. Online ahead of print. Nat Protoc. 2023. PMID: 36964403 Review.
Studies on mouse social behavior often rely on measures such as time spent in contact with a social partner or preference for a social-paired context, but fail to assess volitional (subject-controlled) rewarding social interaction. ...The training comm …
Studies on mouse social behavior often rely on measures such as time spent in contact with a social partner or preference for …
Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity.
Dec E, Clement J, Cheng K, Church GM, Fossel MB, Rehkopf DH, Rosero-Bixby L, Kobor MS, Lin DT, Lu AT, Fei Z, Guo W, Chew YC, Yang X, Putra SED, Reiner AP, Correa A, Vilalta A, Pirazzini C, Passarino G, Monti D, Arosio B, Garagnani P, Franceschi C, Horvath S. Dec E, et al. Geroscience. 2023 Mar 25. doi: 10.1007/s11357-023-00731-7. Online ahead of print. Geroscience. 2023. PMID: 36964402
MRI Assessment of Extramural Venous Invasion Before and After Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer and Its Association with Disease-Free and Overall Survival.
Thompson HM, Bates DDB, Pernicka JG, Park SJ, Nourbakhsh M, Fuqua JL 3rd, Fiasconaro M, Lavery JA, Wei IH, Pappou EP, Smith JJ, Nash GM, Weiser MR, Paty PB, Garcia-Aguilar J, Widmar M. Thompson HM, et al. Ann Surg Oncol. 2023 Mar 24. doi: 10.1245/s10434-023-13225-9. Online ahead of print. Ann Surg Oncol. 2023. PMID: 36964328
Joint COVID-19 and influenza-like illness forecasts in the United States using internet search information.
Ma S, Ning S, Yang S. Ma S, et al. Commun Med (Lond). 2023 Mar 24;3(1):39. doi: 10.1038/s43856-023-00272-2. Commun Med (Lond). 2023. PMID: 36964311 Free PMC article.
METHODS: Inspired by the interconnection between ILI and COVID-19 activities, we combine related internet search and bi-disease time series information for the U.S. national level and state level forecasts. Our proposed ARGOX-Joint-Ensemble adopts a new ensem …
METHODS: Inspired by the interconnection between ILI and COVID-19 activities, we combine related internet search and bi-disease time series …
Cognitive function is mediated by deficit accumulation in older, long-term breast cancer survivors.
Ahles TA, Schofield E, Li Y, Ryan E, Orlow I, Patel SK, Traina T, Root JC. Ahles TA, et al. J Cancer Surviv. 2023 Mar 24. doi: 10.1007/s11764-023-01365-6. Online ahead of print. J Cancer Surviv. 2023. PMID: 36964293
IMPLICATIONS FOR CANCER SURVIVORS: These findings have important clinical implications suggesting that the most effective intervention to prevent or slow cognitive aging in older cancer survivors may be through prevention or management of comorbidities and interventions that main …
IMPLICATIONS FOR CANCER SURVIVORS: These findings have important clinical implications suggesting that the most effective intervention to pr …
Management of Depression in Chronic Care Patients Using a Task-Sharing Approach in a Real-World Primary Health Care Setting in South Africa: Outcomes of a Cohort Study.
Kathree T, Bachmann M, Bhana A, Grant M, Mntambo N, Gigaba S, Kemp CG, Rao D, Petersen I. Kathree T, et al. Community Ment Health J. 2023 Mar 24. doi: 10.1007/s10597-023-01108-y. Online ahead of print. Community Ment Health J. 2023. PMID: 36964282
This study evaluated an integrated, task-sharing collaborative approach to management of depression comorbid with chronic diseases in primary health care (PHC) patients in a real-world setting. Existing HIV clinic counsellors provided a manualised depression counselling in …
This study evaluated an integrated, task-sharing collaborative approach to management of depression comorbid with chronic diseases in primar …
Effects of Nystatin oral rinse on oral Candida species and Streptococcus mutans among healthy adults.
Aljaffary M, Jang H, Alomeir N, Zeng Y, Alkhars N, Vasani S, Almulhim A, Wu TT, Quataert S, Bruno J, Lee A, Xiao J. Aljaffary M, et al. Clin Oral Investig. 2023 Mar 24. doi: 10.1007/s00784-023-04969-5. Online ahead of print. Clin Oral Investig. 2023. PMID: 36964224

RESULTS: Half of participants (10/20) were free of salivary C. albicans after using Nystatin rinse. Salivary S. mutans was significantly reduced at 3-month follow-up (p < 0.05). ...CONCLUSIONS: The study results indicate that oral antifungal treatment had an effect on

RESULTS: Half of participants (10/20) were free of salivary C. albicans after using Nystatin rinse. Salivary S. mutans was significan …
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Read KA, Jones DM, Pokhrel S, Hales EDS, Varkey A, Tuazon JA, Eisele CD, Abdouni O, Saadey A, Leonard MR, Warren RT, Powell MD, Boss JM, Hemann EA, Yount JS, Xin G, Ghoneim HE, Lio CJ, Freud AG, Collins PL, Oestreich KJ. Read KA, et al. Nat Commun. 2023 Mar 24;14(1):1652. doi: 10.1038/s41467-023-37420-0. Nat Commun. 2023. PMID: 36964178 Free PMC article.
Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination.
Sharma J, Mulherkar S, Chen UI, Xiong Y, Bajaj L, Cho BK, Goo YA, Leung HE, Tolias KF, Sardiello M. Sharma J, et al. Cell Discov. 2023 Mar 24;9(1):32. doi: 10.1038/s41421-023-00533-3. Cell Discov. 2023. PMID: 36964131 Free PMC article.
CRISPR/Cas9-mediated knockout of Kctd7 in mice phenotypically recapitulated human KCTD7 deficiency and resulted in calpain hyperactivation, behavioral impairments, and neurodegeneration. ...These results unveil a novel mechanism and potential target to restrain calpain act …
CRISPR/Cas9-mediated knockout of Kctd7 in mice phenotypically recapitulated human KCTD7 deficiency and resulted in calpain hyperactiv …
Histopathology and SARS-CoV-2 cellular localization in eye tissues of COVID-19 autopsies.
Sen HN, Vannella KM, Wang Y, Chung JY, Kodati S, Ramelli SC, Lee JW, Perez P, Stein SR, Grazioli A, Dickey JM, Ylaya K, Singh M, Yinda KC, Platt A, Ramos-Benitez MJ, Zerbe C, Munster VJ, de Wit E, Warner BM, Herr DL, Rabin J, Saharia KK; NIH COVID-19 Autopsy Consortium; Kleiner DE, Hewitt SM, Chan CC, Chertow DS, Stein SR, Ramelli SC, Ramos-Benitez MJ, Platt AP, Dickey JM, Curran SJ, Babyak AL, Valencia LP, Richert ME, Vannella KM, Chertow DS, Kleiner DE, Hewitt SM, Young WJ, Young SP, Gasmi B, De Melo MS, Desar S, Tadros S, Nasir N, Jin X, Rajan S, Dikoglu E, Ozkaya N, Ylaya K, Chung JY, Pittaluga S, Smith G, Emanuel ER, Kelsall B, Olivera JA, Blawas M, Grazioli A, Hays N, Purcell M, Singireddy S, Wu J, Raja K, Curto R, Chung J, Borth A, Bowers K, Weichold A, Minor P, Moshref M, Kelly E, Sajadi MM, Scalea TM, Tran D, Madathil RJ, Dahi S, Deatrick KB, Krause EM, Rabin J, Herrold JA, Tabatabai A, Hochberg E, Cornachione C, Levine AR, Saharia KK, Richards JE, Elder J, Burke A, Mazzeffi MA, Christenson R, Chancer Z, Abdulmahdi M, Sopha S, Goldberg T, Soherwardi S, Sangwan Y, McCurdy MT, Sudano K, Blume D, Radin B, Arnouk M, Eagan JW Jr, Herr DL, Zerbe C. Sen HN, et al. Am J Pathol. 2023 Mar 22:S0002-9440(23)00086-X. doi: 10.1016/j.ajpath.2023.02.016. Online ahead of print. Am J Pathol. 2023. PMID: 36963628 Free PMC article.
Comparative effectiveness of two versions of a caring contacts intervention in healthcare providers, staff, and patients for reducing loneliness and mental distress: A randomized controlled trial.
Radin AK, Shaw J, Brown SP, Torres J, Harper M, Flint H, Fouts T, McCue E, Skeie A, Peña C, Youell J, Doty-Jones A, Wilson J, Flinn L, Austin G, Chan KCG, Zheng Z, Fruhbauerova M, Walton M, Kerbrat A, Comtois KA. Radin AK, et al. J Affect Disord. 2023 Mar 22:S0165-0327(23)00365-8. doi: 10.1016/j.jad.2023.03.029. Online ahead of print. J Affect Disord. 2023. PMID: 36963515
Participants were primary care patients or healthcare providers/staff reporting adverse mental health outcomes on a qualifying survey. Participants were sent 11 standardized caring text messages over 6 months; when participants replied, they received personalized unscripte …
Participants were primary care patients or healthcare providers/staff reporting adverse mental health outcomes on a qualifying survey …
Racial/ethnic disparities in vicarious and direct COVID-19-related discrimination and vigilance.
Hamilton-Moseley KR, Phan L, Hacker K, Jewett B, Ajith A, Chen-Sankey J, Choi K. Hamilton-Moseley KR, et al. Am J Prev Med. 2023 Mar 22:S0749-3797(23)00152-6. doi: 10.1016/j.amepre.2023.03.013. Online ahead of print. Am J Prev Med. 2023. PMID: 36963472 Free PMC article.
In this observational study, both vicariously and directly experienced COVID-19-related discrimination and their association with heightened concerns about discrimination and vigilance were examined in U.S. adults who use commercial tobacco. METHODS: Data were from …
In this observational study, both vicariously and directly experienced COVID-19-related discrimination and their association with heightened …
The Environmental influences on Child Health Outcomes (ECHO)-wide Cohort.
Knapp EA, Kress AM, Parker CB, Page GP, McArthur K, Gachigi KK, Alshawabkeh AN, Aschner JL, Bastain TM, Breton CV, Bendixsen CG, Brennan PA, Bush NR, Buss C, Camargo CA Jr, Catellier D, Cordero JF, Croen L, Dabelea D, Deoni S, D'Sa V, Duarte CS, Dunlop AL, Elliott AJ, Farzan SF, Ferrara A, Ganiban JM, Gern JE, Giardino AP, Towe-Goodman NR, Gold DR, Habre R, Hamra GB, Hartert T, Herbstman JB, Hertz-Picciotto I, Hipwell AE, Karagas MR, Karr CJ, Keenan K, Kerver JM, Koinis-Mitchell D, Lau B, Lester BM, Leve LD, Leventhal B, LeWinn KZ, Lewis J, Litonjua AA, Lyall K, Madan JC, McEvoy CT, McGrath M, Meeker JD, Miller RL, Morello-Frosch R, Neiderhiser JM, O'Connor TG, Oken E, O'Shea M, Paneth N, Porucznik CA, Sathyanarayana S, Schantz SL, Spindel ER, Stanford JB, Stroustrup A, Teitelbaum SL, Trasande L, Volk H, Wadhwa PD, Weiss ST, Woodruff TJ, Wright RJ, Zhao Q, Jacobson LP, Environmental Influences On Child Health Outcomes OBOPCF. Knapp EA, et al. Am J Epidemiol. 2023 Mar 24:kwad071. doi: 10.1093/aje/kwad071. Online ahead of print. Am J Epidemiol. 2023. PMID: 36963379
The Environmental influences on Child Health Outcomes (ECHO)-wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of Health (NIH) in 2016 to improve children's
The Environmental influences on Child Health Outcomes (ECHO)-wide Cohort Study (EWC), a collaborative research design comprising 69 c …
R wave peak time and no reflow following primary percutaneous coronary intervention: Immediate and short-term outcomes.
Yusuf J, Pandey PK, Mehta V, Mukhopadhyay S. Yusuf J, et al. J Electrocardiol. 2023 Mar 12;79:66-74. doi: 10.1016/j.jelectrocard.2023.03.003. Online ahead of print. J Electrocardiol. 2023. PMID: 36963284
ECG papers was analysed using digital image processing software (http://imagej.nih.gov/ij/). All patients were followed up for 6 months. RESULTS: NR was observed in 35% of the patients. ...
ECG papers was analysed using digital image processing software (http://imagej.nih.gov/ij/). All patients were followed up for 6 mont …
An evaluation of programs to support new investigators at the National Institute of Allergy and Infectious Diseases: Striking a balance with funding for established investigators.
Zane AC, Onken J, Parker MB, Ghosh D. Zane AC, et al. Eval Program Plann. 2022 Dec 21;98:102218. doi: 10.1016/j.evalprogplan.2022.102218. Online ahead of print. Eval Program Plann. 2022. PMID: 36963190
As the largest funder of basic biomedical research in the US, the National Institutes of Health (NIH) has an interest in maintaining a sustainable, productive workforce of investigators. ...The latest of these is the Next Generation Researchers Initiat …
As the largest funder of basic biomedical research in the US, the National Institutes of Health (NIH) has an int …
National health policies and strategies for addressing chronic kidney disease: Data from the International Society of Nephrology Global Kidney Health Atlas.
Neuen BL, Bello AK, Levin A, Lunney M, Osman MA, Ye F, Ashuntantang GE, Bellorin-Font E, Gharbi MB, Davison S, Ghnaimat M, Harden P, Jha V, Kalantar-Zadeh K, Kerr PG, Klarenbach S, Kovesdy CP, Luyckx V, Ossareh S, Perl J, Rashid HU, Rondeau E, See EJ, Saad S, Sola L, Tchokhonelidze I, Tesar V, Tungsanga K, Kazancioglu RT, Wang AY, Yang CW, Zemchenkov A, Zhao MH, Jager KJ, Caskey FJ, Perkovic V, Jindal KK, Okpechi IG, Tonelli M, Feehally J, Harris DC, Johnson DW. Neuen BL, et al. PLOS Glob Public Health. 2023 Feb 1;3(2):e0001467. doi: 10.1371/journal.pgph.0001467. eCollection 2023. PLOS Glob Public Health. 2023. PMID: 36963092 Free PMC article.
National strategies for addressing chronic kidney disease (CKD) are crucial to improving kidney health. ...Greater recognition of CKD within national health policy is critical to improving kidney healthcare globally....
National strategies for addressing chronic kidney disease (CKD) are crucial to improving kidney health. ...Greater recognition
Monitoring progress towards elimination of hepatitis B and C in the EU/EEA.
Sharrock KC, Noori T, Axelsson M, Buti M, Diaz A, Fursa O, Hendrickx G, James C, Klavs I, Korenjak M, Maticic M, Mozalevskis A, Peters L, Rigoni R, Rosinska M, Ruutel K, Schatz E, Seyler T, Veldhuijzen I, Duffell E. Sharrock KC, et al. PLOS Glob Public Health. 2022 Aug 17;2(8):e0000841. doi: 10.1371/journal.pgph.0000841. eCollection 2022. PLOS Glob Public Health. 2022. PMID: 36962761 Free PMC article.
In 2017, most countries reporting data had not reached prevention targets for childhood hepatitis B vaccination and for harm reduction services targeting people who inject drugs (PWID). Four of 12 countries had met the target for proportion of people living with chronic HB …
In 2017, most countries reporting data had not reached prevention targets for childhood hepatitis B vaccination and for harm reduction se