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Year Number of Results
1945 1
1952 2
1956 1
1957 1
1958 1
1960 1
1963 2
1964 1
1965 1
1966 4
1967 1
1968 2
1971 2
1972 1
1973 1
1974 6
1975 7
1976 15
1977 20
1978 24
1979 29
1980 28
1981 39
1982 54
1983 62
1984 47
1985 49
1986 38
1987 88
1988 151
1989 162
1990 206
1991 262
1992 267
1993 256
1994 262
1995 300
1996 251
1997 322
1998 383
1999 430
2000 395
2001 484
2002 526
2003 627
2004 746
2005 812
2006 975
2007 1024
2008 1025
2009 1057
2010 1198
2011 1260
2012 1269
2013 1581
2014 2620
2015 3184
2016 2990
2017 2919
2018 4553
2019 5019
2020 5309
2021 6300
2022 5968
2023 4992
2024 3663

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The following term was not found in PubMed: R01HD084515
Page 1
Novel candidate metastasis-associated genes for synovial sarcoma.
Zhao Z, Niu J, Wang J, Zhang R, Liang H, Ma Y, Ferrena A, Wang W, Yang R, Geller DS, Guo W, Ren T, Hoang BH, Tang X, Yan T. Zhao Z, et al. J Cell Mol Med. 2024 Jul;28(14):e18541. doi: 10.1111/jcmm.18541. J Cell Mol Med. 2024. PMID: 39046429
The Availability of Midwifery Care in Rural United States Communities.
Sheffield EC, Fritz AH, Interrante JD, Kozhimannil KB. Sheffield EC, et al. J Midwifery Womens Health. 2024 Jul 23. doi: 10.1111/jmwh.13676. Online ahead of print. J Midwifery Womens Health. 2024. PMID: 39044450
INTRODUCTION: Access to pregnancy-related and childbirth-related health care for rural residents is limited by health workforce shortages in the United States. ...METHODS: We developed and conducted a national survey of rural US hospitals with current …
INTRODUCTION: Access to pregnancy-related and childbirth-related health care for rural residents is limited by health workforc …
Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi.
Choi JY, Gihaz S, Munshi M, Singh P, Vydyam P, Hamel P, Adams EM, Sun X, Khalimonchuk O, Fuller K, Ben Mamoun C. Choi JY, et al. Commun Biol. 2024 Jul 23;7(1):894. doi: 10.1038/s42003-024-06595-7. Commun Biol. 2024. PMID: 39043829 Free PMC article.
Fungal infections, a leading cause of mortality among eukaryotic pathogens, pose a growing global health threat due to the rise of drug-resistant strains. New therapeutic strategies are urgently needed to combat this challenge. ...
Fungal infections, a leading cause of mortality among eukaryotic pathogens, pose a growing global health threat due to the rise of dr …
Human cytomegalovirus in breast milk is associated with milk composition and the infant gut microbiome and growth.
Johnson KE, Hernandez-Alvarado N, Blackstad M, Heisel T, Allert M, Fields DA, Isganaitis E, Jacobs KM, Knights D, Lock EF, Rudolph MC, Gale CA, Schleiss MR, Albert FW, Demerath EW, Blekhman R. Johnson KE, et al. Nat Commun. 2024 Jul 23;15(1):6216. doi: 10.1038/s41467-024-50282-4. Nat Commun. 2024. PMID: 39043677 Free PMC article.
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus that is often transmitted to the neonate via breast milk. Postnatal CMV transmission can have negative health consequences for preterm and immunocompromised infants, but any effects on healthy term infant
Human cytomegalovirus (CMV) is a highly prevalent herpesvirus that is often transmitted to the neonate via breast milk. Postnatal CMV
Obesity increases genomic instability at DNA repeat-mediated endogenous mutation hotspots.
Kompella P, Wang G, Durrett RE, Lai Y, Marin C, Liu Y, Habib SL, DiGiovanni J, Vasquez KM. Kompella P, et al. Nat Commun. 2024 Jul 23;15(1):6213. doi: 10.1038/s41467-024-50006-8. Nat Commun. 2024. PMID: 39043652 Free PMC article.
., H-DNA) stimulate mutations and are enriched at mutation hotspots in human cancer genomes. However, it is not known if obesity impacts DNA repeat-mediated endogenous mutation hotspots. We address this gap by measuring mutation frequencies in obese and normal-weight trans …
., H-DNA) stimulate mutations and are enriched at mutation hotspots in human cancer genomes. However, it is not known if obesity impa …
Neural and behavioral markers of inhibitory control predict symptom improvement during internet-delivered cognitive behavioral therapy for depression.
Thai M, Olson EA, Nickels S, Dillon DG, Webb CA, Ren B, Killgore WDS, Rauch SL, Rosso IM, Pizzagalli DA. Thai M, et al. Transl Psychiatry. 2024 Jul 23;14(1):303. doi: 10.1038/s41398-024-03020-9. Transl Psychiatry. 2024. PMID: 39043642 Free PMC article. Clinical Trial.
Elastic net regression was used to predict post-treatment Patient Health Questionnaire-9 (PHQ-9) scores from baseline variables, including demographic variables, PHQ-9 scores, Flanker effects (interference, sequential dependency, post-error slowing), and rsFC between the d …
Elastic net regression was used to predict post-treatment Patient Health Questionnaire-9 (PHQ-9) scores from baseline variables, incl …
The Community-Based Health Workforce in Public Health and Health Care Delivery.
Ahmed K, Presley-Cantrell L, Moeti R, Wong D, Freese KL, Taplin C, Rodrigue J, Spencer TD, Hacker K. Ahmed K, et al. J Public Health Manag Pract. 2024 Sep-Oct 01;30(5):E264-E269. doi: 10.1097/PHH.0000000000001911. Epub 2024 Jul 22. J Public Health Manag Pract. 2024. PMID: 39041776
CONTEXT: The "community-based workforce" is an umbrella term used by a workgroup of U.S. Department of Health and Human Services (HHS) leaders to characterize a variety of job titles and descriptions for positions in the public health
CONTEXT: The "community-based workforce" is an umbrella term used by a workgroup of U.S. Department of Health an …
Rapid Online Data Collection and Reporting to Local Health Departments during the Pandemic: The COVID-19 Outbreak Public Evaluation (COPE) Initiative SARS-CoV-2 Case Surveys.
Booker LA, Czeisler MÉ, Lane RI, Orellana RC, Lundeen K, Macomber K, Collins J, Varma P, Rajaratnam SMW, Howard ME, Czeisler CA, Weaver MD. Booker LA, et al. J Public Health Manag Pract. 2024 Sep-Oct 01;30(5):E224-E229. doi: 10.1097/PHH.0000000000002017. Epub 2024 Jul 22. J Public Health Manag Pract. 2024. PMID: 39041775
OBJECTIVES: To develop and implement a pilot online data collection tool to help local health departments with their COVID-19 pandemic response efforts and inform health department actions. ...Identical items were administered to demographically representativ …
OBJECTIVES: To develop and implement a pilot online data collection tool to help local health departments with their COVID-19 pandemi …
Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model.
Leuzy A, Raket LL, Villemagne VL, Klein G, Tonietto M, Olafson E, Baker S, Saad ZS, Bullich S, Lopresti B, Bohorquez SS, Boada M, Betthauser TJ, Charil A, Collins EC, Collins JA, Cullen N, Gunn RN, Higuchi M, Hostetler E, Hutchison RM, Iaccarino L, Insel PS, Irizarry MC, Jack CR Jr, Jagust WJ, Johnson KA, Johnson SC, Karten Y, Marquié M, Mathotaarachchi S, Mintun MA, Ossenkoppele R, Pappas I, Petersen RC, Rabinovici GD, Rosa-Neto P, Schwarz CG, Smith R, Stephens AW, Whittington A, Carrillo MC, Pontecorvo MJ, Haeberlein SB, Dunn B, Kolb HC, Sivakumaran S, Rowe CC, Hansson O, Doré V. Leuzy A, et al. Alzheimers Dement. 2024 Jul 23. doi: 10.1002/alz.13908. Online ahead of print. Alzheimers Dement. 2024. PMID: 39041435
Quantitative outcomes of a type 2 single arm hybrid effectiveness implementation pilot study for hypertension-HIV integration in Botswana.
Moshomo T, Gaolathe T, Ramotsababa M, Molefe-Baikai OJ, Mogaetsho E, Dintwa E, Gala P, Ponatshego P, Bogart LM, Youssouf N, Seipone K, Van Pelt AE, Bennett K, Jaffar S, Ilias M, Tonwe V, Hurwitz KW, Kebotsamang K, Steger-May K, Hirschhorn LR, Mosepele M. Moshomo T, et al. Implement Sci Commun. 2024 Jul 22;5(1):80. doi: 10.1186/s43058-024-00620-w. Implement Sci Commun. 2024. PMID: 39039609 Free PMC article.
Based on our formative work, we adopted three main strategies; Health worker training on HTN/cardiovascular disease (CVD) management, adaptation of HIV Electronic Health Record (EHR) for HTN/CVD care, and use of treatment partners to support PWH with hypertension fo …
Based on our formative work, we adopted three main strategies; Health worker training on HTN/cardiovascular disease (CVD) management, …
BNP-Track: a framework for superresolved tracking.
Sgouralis I, Xu LWQ, Jalihal AP, Kilic Z, Walter NG, Pressé S. Sgouralis I, et al. Nat Methods. 2024 Jul 22. doi: 10.1038/s41592-024-02349-9. Online ahead of print. Nat Methods. 2024. PMID: 39039336
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases.
Ferreira da Silva J, Tou CJ, King EM, Eller ML, Rufino-Ramos D, Ma L, Cromwell CR, Metovic J, Benning FMC, Chao LH, Eichler FS, Kleinstiver BP. Ferreira da Silva J, et al. Nat Biotechnol. 2024 Jul 22. doi: 10.1038/s41587-024-02324-x. Online ahead of print. Nat Biotechnol. 2024. PMID: 39039307
Through iterative optimization of the modular components of CEs and their clkDNAs, we demonstrate the ability to install precise genome edits with minimal indels in diverse immortalized human cell types and primary fibroblasts with precise editing efficiencies of up to ~30 …
Through iterative optimization of the modular components of CEs and their clkDNAs, we demonstrate the ability to install precise genome edit …
A foundation model for clinical-grade computational pathology and rare cancers detection.
Vorontsov E, Bozkurt A, Casson A, Shaikovski G, Zelechowski M, Severson K, Zimmermann E, Hall J, Tenenholtz N, Fusi N, Yang E, Mathieu P, van Eck A, Lee D, Viret J, Robert E, Wang YK, Kunz JD, Lee MCH, Bernhard JH, Godrich RA, Oakley G, Millar E, Hanna M, Wen H, Retamero JA, Moye WA, Yousfi R, Kanan C, Klimstra DS, Rothrock B, Liu S, Fuchs TJ. Vorontsov E, et al. Nat Med. 2024 Jul 22. doi: 10.1038/s41591-024-03141-0. Online ahead of print. Nat Med. 2024. PMID: 39039250
Reprogramming human B cells with custom heavy-chain antibodies.
Rogers GL, Huang C, Mathur A, Huang X, Chen HY, Stanten K, Morales H, Chang CH, Kezirian EJ, Cannon PM. Rogers GL, et al. Nat Biomed Eng. 2024 Jul 22. doi: 10.1038/s41551-024-01240-4. Online ahead of print. Nat Biomed Eng. 2024. PMID: 39039240
Using the envelope protein (Env) from the human immunodeficiency virus as a model antigen, we show that B cells edited to express heavy-chain antibodies to Env support the regulated expression of B cell receptors and antibodies through alternative splicing and that the cel …
Using the envelope protein (Env) from the human immunodeficiency virus as a model antigen, we show that B cells edited to express hea …
Neuroimaging for precision medicine in psychiatry.
Williams LM, Whitfield Gabrieli S. Williams LM, et al. Neuropsychopharmacology. 2024 Jul 22. doi: 10.1038/s41386-024-01917-z. Online ahead of print. Neuropsychopharmacology. 2024. PMID: 39039140 Review.
Targeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses.
Johnson BS, Farkas D, El-Mergawy R, Adair JA, Elhance A, Eltobgy M, Coan FM, Chafin L, Joseph JA, Cornwell A, Johns FJ, Rosas L, Rojas M, Farkas L, Bednash JS, Londino JD, Ray P, Ray A, Kagan V, Lee JS, Chen BB, Mallampalli RK. Johnson BS, et al. Nat Commun. 2024 Jul 22;15(1):6172. doi: 10.1038/s41467-024-50031-7. Nat Commun. 2024. PMID: 39039092 Free PMC article.
Dielectrophoretic bead-droplet reactor for solid-phase synthesis.
Padhy P, Zaman MA, Jensen MA, Cheng YT, Huang Y, Wu M, Galambos L, Davis RW, Hesselink L. Padhy P, et al. Nat Commun. 2024 Jul 22;15(1):6159. doi: 10.1038/s41467-024-49284-z. Nat Commun. 2024. PMID: 39039069 Free PMC article.
Post-COVID Conditions in US Primary Care: A PRIME Registry Comparison of Patients With COVID-19, Influenza-Like Illness, and Wellness Visits.
Velásquez EE, Kamdar NS, Rehkopf DH, Saydah S, Bull-Otterson L, Hao S, Vala A, Chu I, Bazemore AW, Phillips RL, Boehmer T. Velásquez EE, et al. Ann Fam Med. 2024 Jul-Aug;22(4):279-287. doi: 10.1370/afm.3131. Ann Fam Med. 2024. PMID: 39038980 Free PMC article.
We used a novel primary care registry to quantify the burden of post-COVID conditions among adult patients with a COVID-19 diagnosis across the United States. METHODS: We used the American Family Cohort, a national primary care registry, to identify study patients. …
We used a novel primary care registry to quantify the burden of post-COVID conditions among adult patients with a COVID-19 diagnosis across …
Changes in Emergency Department Pediatric Readiness and Mortality.
Newgard CD, Rakshe S, Salvi A, Lin A, Cook JNB, Gausche-Hill M, Kuppermann N, Goldhaber-Fiebert JD, Burd RS, Malveau S, Jenkins PC, Stephens CQ, Glass NE, Hewes H, Mann NC, Ames SG, Fallat M, Jensen AR, Ford RL, Child A, Carr B, Lang K, Buchwalder K, Remick KE. Newgard CD, et al. JAMA Netw Open. 2024 Jul 1;7(7):e2422107. doi: 10.1001/jamanetworkopen.2024.22107. JAMA Netw Open. 2024. PMID: 39037816 Free PMC article.
IMPORTANCE: High emergency department (ED) pediatric readiness is associated with improved survival, but the impact of changes to ED readiness is unknown. ...DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was performed from January 1, 2012, through Dece …
IMPORTANCE: High emergency department (ED) pediatric readiness is associated with improved survival, but the impact of changes to ED …
Anticipatory Guidance: Developing a Patient Navigation Pathway to Reduce the Financial Toxicity of Cancer.
Cheung CK, Jones L, Lee H, Bridges JN, Tucker-Seeley R, Vyfhuis MAL, Gianelle MC, Thomas BN, Betz G, Waldo L, Hirsch AS, Ntiri SO. Cheung CK, et al. Med Res Arch. 2023 Oct;11(10):10.18103/mra.v11i10.4582. doi: 10.18103/mra.v11i10.4582. Epub 2023 Oct 25. Med Res Arch. 2023. PMID: 39036741 Free PMC article.
AIMS: The purpose of this study is to develop a novel financial navigation pathway that leverages existing patient financial services and resources with corresponding patient-centered, community-informed strategies, via study participants, that may be utilized in routine c …
AIMS: The purpose of this study is to develop a novel financial navigation pathway that leverages existing patient financial services
Implementing evidence-based practices in rural settings: a scoping review of theories, models, and frameworks.
Brady RE, Lyons KD, Stevens CJ, Godzik CM, Smith AJ, Bagley PJ, Vitale EJ, Bernstein SL. Brady RE, et al. Front Health Serv. 2024 Jul 5;4:1326777. doi: 10.3389/frhs.2024.1326777. eCollection 2024. Front Health Serv. 2024. PMID: 39036464 Free PMC article.
The present scoping review sought to identify the theories, models, and frameworks most frequently applied to rural health and propose an approach to rural health research that harnesses selected constructs from these theories, models, and frameworks. ...RESULTS: We …
The present scoping review sought to identify the theories, models, and frameworks most frequently applied to rural health and propos …
Physical activity moderates the association between school start time and sleep duration in a cross-sectional national sample of adolescents.
Farley ZS, Ward M, Giuliani NR, Budd EL. Farley ZS, et al. J Act Sedentary Sleep Behav. 2024;3(1):11. doi: 10.1186/s44167-024-00050-y. Epub 2024 May 6. J Act Sedentary Sleep Behav. 2024. PMID: 39035876 Free PMC article.
METHODS: This study examined data (collected in April and October 2014) from a national sample of 1132 adolescents (m (age) = 14.5 years) living in the United States from the Family Life, Activity, Sun, Health, and Eating study, a cross-sectional, internet-ba …
METHODS: This study examined data (collected in April and October 2014) from a national sample of 1132 adolescents (m (age) = 14.5 years) li …
Effectiveness of SNAPPS Implementation in the Family Medicine Residency Program in Erbil: A Randomized Controlled Trial.
Shindala GS, Dauod AS, Alkhateeb NE. Shindala GS, et al. Cureus. 2024 Jul 19;16(7):e64897. doi: 10.7759/cureus.64897. eCollection 2024 Jul. Cureus. 2024. PMID: 39035591 Free PMC article.
Using convenience sampling, all Family Medicine board residents (n=30) in Erbil and six preceptors from the Community and Family Medicine department/College of Medicine/Hawler Medical University were randomly assigned into two groups by using the RAND function in Microsoft …
Using convenience sampling, all Family Medicine board residents (n=30) in Erbil and six preceptors from the Community and Family Medicine …
Hormone therapy is associated with lower Alzheimer's disease tau biomarkers in post-menopausal females -evidence from two independent cohorts.
Wang YT, Therriault J, Tissot C, Servaes S, Rahmouni N, Macedo AC, Fernandez-Arias J, Mathotaarachchi SS, Stevenson J, Lussier FZ, Benedet AL, Pascoal TA, Ashton NJ, Zetterberg H, Blennow K, Gauthier S, Rosa-Neto P. Wang YT, et al. Alzheimers Res Ther. 2024 Jul 22;16(1):162. doi: 10.1186/s13195-024-01509-5. Alzheimers Res Ther. 2024. PMID: 39034389 Free PMC article.
The genetic evolution of acral melanoma.
Wang M, Fukushima S, Sheen YS, Ramelyte E, Cruz-Pacheco N, Shi C, Liu S, Banik I, Aquino JD, Sangueza Acosta M, Levesque M, Dummer R, Liau JY, Chu CY, Shain AH, Yeh I, Bastian BC. Wang M, et al. Nat Commun. 2024 Jul 21;15(1):6146. doi: 10.1038/s41467-024-50233-z. Nat Commun. 2024. PMID: 39034322 Free article.
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression.
Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Duncan RP, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith ZR, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Asantewaa G, et al. Nat Commun. 2024 Jul 21;15(1):6152. doi: 10.1038/s41467-024-50454-2. Nat Commun. 2024. PMID: 39034312 Free article.
Policy, Systems, and Environmental (PSE) Strategies to Support Healthy Eating Behaviors in Early Childhood: A Scoping Review of Existing Evaluation Tools.
Varela EG, Shelnutt KP, Miller D, Zeldman J, Mobley AR. Varela EG, et al. J Acad Nutr Diet. 2024 Jul 19:S2212-2672(24)00720-2. doi: 10.1016/j.jand.2024.07.160. Online ahead of print. J Acad Nutr Diet. 2024. PMID: 39033923
METHODS: Three databases (PubMed, CINAHL, and Web of Science) were used to systematically search for articles published between 2013 and 2023 written in English and conducted in the United States (US) that evaluated PSE change strategies supporting healthy eating be …
METHODS: Three databases (PubMed, CINAHL, and Web of Science) were used to systematically search for articles published between 2013 and 202 …
Nurse Corps' impact on increasing registered nurse staffing in critical shortage areas and facilities, 2017 to 2022.
Donelan K, Hesgrove B, Nooney JG, Liu H, Heely C, Kreiger N, Ziomek SB, Kepley HO. Donelan K, et al. Nurs Outlook. 2024 Jul 20;72(5):102233. doi: 10.1016/j.outlook.2024.102233. Online ahead of print. Nurs Outlook. 2024. PMID: 39033570
BACKGROUND: The registered nurse (RN) workforce experienced critical pre-pandemic and pandemic shortages of labor in some areas in the United States. People living in these health professional shortage areas (HPSAs) may have less access to health se
BACKGROUND: The registered nurse (RN) workforce experienced critical pre-pandemic and pandemic shortages of labor in some areas in the Un
Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task.
Savage HS, Mulders PCR, van Eijndhoven PFP, van Oort J, Tendolkar I, Vrijsen JN, Beckmann CF, Marquand AF. Savage HS, et al. Commun Biol. 2024 Jul 20;7(1):888. doi: 10.1038/s42003-024-06573-z. Commun Biol. 2024. PMID: 39033247 Free article.
We apply this model to a heterogenous patient cohort, to map individual differences between patients with one or more mental health diagnoses relative to the reference cohort and determine multivariate associations with transdiagnostic symptom domains. ...
We apply this model to a heterogenous patient cohort, to map individual differences between patients with one or more mental health d …
A scoping review of global COVID-19 vaccine hesitancy among pregnant persons.
Casubhoy I, Kretz A, Tan HL, St Clair LA, Parish M, Golding H, Bersoff-Matcha SJ, Pilgrim-Grayson C, Berhane L, Pekosz A, Mostafa HH, Cox AL, Burd I, Klein SL, Morgan R. Casubhoy I, et al. NPJ Vaccines. 2024 Jul 20;9(1):131. doi: 10.1038/s41541-024-00913-0. NPJ Vaccines. 2024. PMID: 39033194 Free article.
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency.
Tesla R, Guhl C, Werthmann GC, Dixon D, Cenik B, Addepalli Y, Liang J, Fass DM, Rosenthal Z, Haggarty SJ, Williams NS, Posner BA, Ready JM, Herz J. Tesla R, et al. Nat Commun. 2024 Jul 20;15(1):6125. doi: 10.1038/s41467-024-50076-8. Nat Commun. 2024. PMID: 39033178 Free article.
This work describes a series of blood-brain-barrier-penetrant small molecules which significantly increase progranulin protein levels in human cellular models, correct progranulin protein deficiency in Grn(+/-) mouse brains, and reverse lysosomal proteome aberrations, a ph …
This work describes a series of blood-brain-barrier-penetrant small molecules which significantly increase progranulin protein levels in …
Advances in induced pluripotent stem cell-derived cardiac myocytes: technological breakthroughs, key discoveries and new applications.
Clancy CE, Santana LF. Clancy CE, et al. J Physiol. 2024 Jul 20. doi: 10.1113/JP282562. Online ahead of print. J Physiol. 2024. PMID: 39032073
Here, we delve into these advancements and their future promise, focusing on the efficiency of reprogramming techniques, the fidelity of differentiation into the cardiac lineage, the functional characterization of the resulting cardiac myocytes, and the many applications of in si …
Here, we delve into these advancements and their future promise, focusing on the efficiency of reprogramming techniques, the fidelity of dif …
"Will you need this health at all? Will you be alive?": using the bioecological model of mass trauma to understand HIV care experiences during the war in Ukraine.
Owczarzak J, Monton O, Fuller S, Burlaka J, Kiriazova T, Morozova O, Dumchev K. Owczarzak J, et al. J Int AIDS Soc. 2024 Jul;27 Suppl 3(Suppl 3):e26307. doi: 10.1002/jia2.26307. J Int AIDS Soc. 2024. PMID: 39030874 Free PMC article.
Participants completed a single interview that explored how the war had affected their daily lives and access to HIV care and other medical services; their relationships with healthcare providers and social workers; and medication access, supply and adherence. ...Pa …
Participants completed a single interview that explored how the war had affected their daily lives and access to HIV care and other medical …
Can flash glucose monitoring improve glucose management for Aboriginal and Torres Strait Islander peoples with type 2 diabetes? A protocol for a randomised controlled trial.
Hachem M, Hearn T, Kelly R, Eer A, Moore B, Sommerville C, Atkinson-Briggs S, Twigg S, Freund M, O'Neal D, Story D, Brown A, McLean A, Sinha A, Furler J, O'Brien R, Tran Duy A, Clarke P, Braat S, Koye DN, Eades S, Burchill L, Ekinci E. Hachem M, et al. Trials. 2024 Jul 19;25(1):493. doi: 10.1186/s13063-024-08267-7. Trials. 2024. PMID: 39030640 Free PMC article.
Secondary outcomes include (i) CGM-derived metrics, (ii) frequency of hypoglycaemic episodes, (iii) health-related quality of life and (iv) incremental cost per quality-adjusted life year gained associated with the CGM compared to SMBG. Clinical trial sites include Aborigi …
Secondary outcomes include (i) CGM-derived metrics, (ii) frequency of hypoglycaemic episodes, (iii) health-related quality of life an …
Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms.
Jiang H, Miller BD, Viennet T, Kim H, Lee K, Arthanari H, Cole PA. Jiang H, et al. Nat Chem. 2024 Jul 19. doi: 10.1038/s41557-024-01576-z. Online ahead of print. Nat Chem. 2024. PMID: 39030419
Lys ubiquitination is catalysed by E3 ubiquitin ligases and is central to the regulation of protein stability and cell signalling in normal and disease states. There are gaps in our understanding of E3 mechanisms, and here we use protein semisynthesis, chemical rescue, mic …
Lys ubiquitination is catalysed by E3 ubiquitin ligases and is central to the regulation of protein stability and cell signalling in normal …
Diversity of post-translational modifications and cell signaling revealed by single cell and single organelle mass spectrometry.
Mun DG, Bhat FA, Joshi N, Sandoval L, Ding H, Jain A, Peterson JA, Kang T, Pujari GP, Tomlinson JL, Budhraja R, Zenka RM, Kannan N, Kipp BR, Dasari S, Gaspar-Maia A, Smoot RL, Kandasamy RK, Pandey A. Mun DG, et al. Commun Biol. 2024 Jul 19;7(1):884. doi: 10.1038/s42003-024-06579-7. Commun Biol. 2024. PMID: 39030393 Free article.
By optimizing the mass spectrometry data interpretation strategy to enable the detection of PTMs and variants, we have generated a high-definition dataset of single-cell and nuclear proteomic-states. The data demonstrate the heterogeneity of cell-states and signalin …
By optimizing the mass spectrometry data interpretation strategy to enable the detection of PTMs and variants, we have generated a high-defi …
Maternal, neonatal, and nutritional risk factors for medical and surgical necrotizing enterocolitis.
Essex C, Hegedus C, Vincent K, Shiflett A, Rohrer A, Chetta KE. Essex C, et al. J Perinatol. 2024 Jul 19. doi: 10.1038/s41372-024-02066-3. Online ahead of print. J Perinatol. 2024. PMID: 39030319
Infants with surgical NEC had higher abdominal circumferences at birth. Maternal milk intake and receipt of human milk fortifiers were associated with medical NEC, and infants receiving fortified, maternal milk showed the lowest progression to surgery/death. ...
Infants with surgical NEC had higher abdominal circumferences at birth. Maternal milk intake and receipt of human milk fortifiers wer …
Large language models outperform mental and medical health care professionals in identifying obsessive-compulsive disorder.
Kim J, Leonte KG, Chen ML, Torous JB, Linos E, Pinto A, Rodriguez CI. Kim J, et al. NPJ Digit Med. 2024 Jul 19;7(1):193. doi: 10.1038/s41746-024-01181-x. NPJ Digit Med. 2024. PMID: 39030292 Free article.
We assessed the diagnostic accuracy of LLMs in OCD using vignettes and found that LLMs outperformed medical and mental health professionals. This highlights the potential benefit of LLMs in assisting in the timely and accurate diagnosis of OCD, which usually entails a long …
We assessed the diagnostic accuracy of LLMs in OCD using vignettes and found that LLMs outperformed medical and mental health profess …
Sleep patterns and risk of chronic disease as measured by long-term monitoring with commercial wearable devices in the All of Us Research Program.
Zheng NS, Annis J, Master H, Han L, Gleichauf K, Ching JH, Nasser M, Coleman P, Desine S, Ruderfer DM, Hernandez J, Schneider LD, Brittain EL. Zheng NS, et al. Nat Med. 2024 Jul 19. doi: 10.1038/s41591-024-03155-8. Online ahead of print. Nat Med. 2024. PMID: 39030265
Poor sleep health is associated with increased all-cause mortality and incidence of many chronic conditions. ...Here, using objectively measured, longitudinal sleep data from commercial wearable devices linked to electronic health record data from the All of Us Rese …
Poor sleep health is associated with increased all-cause mortality and incidence of many chronic conditions. ...Here, using objective …
Genomic and immune determinants of resistance to daratumumab-based therapy in relapsed refractory multiple myeloma.
Ziccheddu B, Giannotta C, D'Agostino M, Bertuglia G, Saraci E, Oliva S, Genuardi E, Papadimitriou M, Diamond B, Corradini P, Coffey D, Landgren O, Bolli N, Bruno B, Boccadoro M, Massaia M, Maura F, Larocca A. Ziccheddu B, et al. Blood Cancer J. 2024 Jul 19;14(1):117. doi: 10.1038/s41408-024-01096-6. Blood Cancer J. 2024. PMID: 39030183 Free article.
Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS.
Zhang X, Venkatachalapathy S, Paysan D, Schaerer P, Tripodo C, Uhler C, Shivashankar GV. Zhang X, et al. Nat Commun. 2024 Jul 20;15(1):6112. doi: 10.1038/s41467-024-50285-1. Nat Commun. 2024. PMID: 39030176 Free article.
Using representation learning on chromatin images alone, without multiplexed staining or high-throughput sequencing, we identify eight morphological cell states and tissue features marking DCIS. All cell states are observed in all disease stages with different propo …
Using representation learning on chromatin images alone, without multiplexed staining or high-throughput sequencing, we identify eight morph …
Nursing peer feedback: Optimizing our relationships with human resources and collective bargaining organizations.
Baldwin CA, Krumm AM, Sy A, Thomas J, Jones A, Ward EK. Baldwin CA, et al. Nurs Outlook. 2024 Jul 18;72(5):102238. doi: 10.1016/j.outlook.2024.102238. Online ahead of print. Nurs Outlook. 2024. PMID: 39029447 Free article.
Peer-to-peer feedback and peer review are widely effective for nurse professionalism and self-regulation, patient care outcomes, and retention. Unprofessional behavior has been noted as widespread in health care and the effects on patients, clinicians, and organizations ha …
Peer-to-peer feedback and peer review are widely effective for nurse professionalism and self-regulation, patient care outcomes, and retenti …
Insights into canine rabies vaccination Disparities in Sierra Leone: A cross-sectional household study.
Mshelbwala PP, Wangdi K, Bunting-Graden JA, Bamayange S, Adamu AM, Gupta SD, Suluku R, Adamu CS, Weese JS, Rupprecht CE, Clark NJ. Mshelbwala PP, et al. PLoS Negl Trop Dis. 2024 Jul 19;18(7):e0012332. doi: 10.1371/journal.pntd.0012332. Online ahead of print. PLoS Negl Trop Dis. 2024. PMID: 39028761 Free article.
Annually, Sierra Leone records an estimated 301 human fatalities due to rabies. Canine vaccination is crucial for rabies prevention and control efforts. ...These data do not support Sierra Leone reaching the 2030 goal of human rabies elimination caused by dogs. Our …
Annually, Sierra Leone records an estimated 301 human fatalities due to rabies. Canine vaccination is crucial for rabies prevention a …
No Association Between Medicare Advantage Providers' Network Restrictiveness and Star Rating Between 2013 and 2017: An Observational Study.
Dai D, Feyman Y, Figueroa JF, Frakt AB, Garrido MM. Dai D, et al. J Gen Intern Med. 2024 Jul 19. doi: 10.1007/s11606-024-08938-w. Online ahead of print. J Gen Intern Med. 2024. PMID: 39028405
OBJECTIVE: We evaluated whether there are meaningful associations between provider network restrictiveness (across primary care, psychiatry, and endocrinology providers) and contracts' overall star quality rating, as well as between network restrictiveness and contracts' performa …
OBJECTIVE: We evaluated whether there are meaningful associations between provider network restrictiveness (across primary care, psychiatry, …
The effects of in utero exposure to delta-9-tetrahydrocannabinol (THC) on cardiac extracellular matrix expression and vascular transcriptome in rhesus macaques.
Le H, Shorey-Kendrick LE, Hinds MT, McCarty OJT, Lo JO, Anderson DEJ. Le H, et al. Am J Physiol Heart Circ Physiol. 2024 Jul 19. doi: 10.1152/ajpheart.00181.2024. Online ahead of print. Am J Physiol Heart Circ Physiol. 2024. PMID: 39028280
Delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis, remains a schedule I substance, thus safety data regarding the effects on the cardiovascular and prenatal health are limited. Importantly, there is evidence showing prenatal cannabis exposure can n …
Delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis, remains a schedule I substance, thus safety data regarding the e …
Artificial Intelligence in Military Medicine.
Leone RM, Chambers JA, Donham BP, Junker CA. Leone RM, et al. Mil Med. 2024 Jul 19:usae359. doi: 10.1093/milmed/usae359. Online ahead of print. Mil Med. 2024. PMID: 39028176
Although many AI applications in military medicine are theoretical, the U.S. Military has implemented several initiatives, often without widespread awareness among its personnel. ...The article also advocates for a forward-thinking approach for the U.S
Although many AI applications in military medicine are theoretical, the U.S. Military has implemented several initiatives, oft …
Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling.
Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MCQ, Franco ML, Özcan B, Gomes Moreira D, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L. Zoltowska KM, et al. Elife. 2024 Jul 19;12:RP90690. doi: 10.7554/eLife.90690. Elife. 2024. PMID: 39027984 Free PMC article.
We conducted kinetic analyses of gamma-secretase activity in cell-free systems in the presence of Abeta, as well as cell-based and ex vivo assays in neuronal cell lines, neurons, and brain synaptosomes to assess the impact of Abeta on gamma-secretases. We show that human A …
We conducted kinetic analyses of gamma-secretase activity in cell-free systems in the presence of Abeta, as well as cell-based and ex vivo a …
Navigating new normals: the influence of COVID-19 policies on community access and well-being of people with mobility disabilities in everyday life.
Wendel CL, Gray RC, Goddard K, Hall JP. Wendel CL, et al. Front Public Health. 2024 Jul 4;12:1401777. doi: 10.3389/fpubh.2024.1401777. eCollection 2024. Front Public Health. 2024. PMID: 39026588 Free PMC article.
CONTEXT: This study explores the influence of COVID-19 public health mandates on people with mobility disabilities in the United States in their everyday lives. It highlights the intersection of disability with social determinants of health, emp …
CONTEXT: This study explores the influence of COVID-19 public health mandates on people with mobility disabilities in the United
Pre-diagnosis tea and coffee consumption and survival after a diagnosis of ovarian cancer: results from the Ovarian Cancer Association Consortium.
Nagle CM, Ibiebele TI, Bandera EV, Cramer D, Doherty JA, Giles GG, Goodman MT, Hanley GE, Harris HR, Jensen A, Kjaer SK, Lee AW, Milne RL, Qin B, Richardson J, Sasamoto N, Sieh W, Terry KL, Titus L, Trabert B, Wentzensen N, Wu AH, Berchuck A, Pike M, Pearce CL, Webb PM. Nagle CM, et al. Br J Cancer. 2024 Jul 18. doi: 10.1038/s41416-024-02792-7. Online ahead of print. Br J Cancer. 2024. PMID: 39026080
Suppression of viral rebound by a Rev-dependent lentiviral particle in SIV-infected rhesus macaques.
Hetrick B, Siddiqui S, Spear M, Guo J, Liang H, Fu Y, Yang Z, Doyle-Meyers L, Pahar B, Veazey RS, Dufour J, Andalibi A, Ling B, Wu Y. Hetrick B, et al. Gene Ther. 2024 Jul 18. doi: 10.1038/s41434-024-00467-9. Online ahead of print. Gene Ther. 2024. PMID: 39025983
Persistence of human immunodeficiency virus (HIV) reservoirs prevents viral eradication, and consequently HIV-infected patients require lifetime treatment with antiretroviral therapy (ART) [1-5]. ...
Persistence of human immunodeficiency virus (HIV) reservoirs prevents viral eradication, and consequently HIV-infected patients requi …
Gα13 restricts nutrient driven proliferation in mucosal germinal centers.
Nguyen HT, Li M, Vadakath R, Henke KA, Tran TC, Li H, Yamadi M, Darbha S, Yang Y, Kabat J, Albright AR, Centeno EG, Phelan JD, Roulland S, Huang DW, Kelly MC, Young RM, Pittaluga S, Difilippantonio S, Muppidi JR. Nguyen HT, et al. Nat Immunol. 2024 Jul 18. doi: 10.1038/s41590-024-01910-0. Online ahead of print. Nat Immunol. 2024. PMID: 39025963
Treatment of IDH-mutant glioma in the INDIGO era.
Lin MD, Tsai AC, Abdullah KG, McBrayer SK, Shi DD. Lin MD, et al. NPJ Precis Oncol. 2024 Jul 19;8(1):149. doi: 10.1038/s41698-024-00646-2. NPJ Precis Oncol. 2024. PMID: 39025958 Free PMC article. Review.
Chromatin conformation and histone modification profiling across human kidney anatomic regions.
Li H, Li D, Humphreys BD. Li H, et al. Sci Data. 2024 Jul 18;11(1):797. doi: 10.1038/s41597-024-03648-8. Sci Data. 2024. PMID: 39025878 Free PMC article.
The three major anatomic regions of the human kidney include the cortex, medulla and papilla, with different functions and vulnerabilities to kidney diseases. ...All raw and processed data files are publicly available, allowing researchers to survey the epigenetic landscap …
The three major anatomic regions of the human kidney include the cortex, medulla and papilla, with different functions and vulnerabil …
Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis.
Li D, Pain O, Chiara F, Wong WLE, Lo CWH, Ripke S, Cattaneo A, Souery D, Dernovsek MZ, Henigsberg N, Hauser J, Lewis G, Mors O, Perroud N, Rietschel M, Uher R, Maier W, Baune BT, Biernacka JM, Bondolfi G, Domschke K, Kato M, Liu YL, Serretti A, Tsai SJ, Weinshilboum R; GSRD Consortium, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; McIntosh AM, Lewis CM. Li D, et al. Transl Psychiatry. 2024 Jul 19;14(1):296. doi: 10.1038/s41398-024-02981-1. Transl Psychiatry. 2024. PMID: 39025838 Free PMC article.
Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer.
Kitai H, Choi PH, Yang YC, Boyer JA, Whaley A, Pancholi P, Thant C, Reiter J, Chen K, Markov V, Taniguchi H, Yamaguchi R, Ebi H, Evans J, Jiang J, Lee B, Wildes D, de Stanchina E, Smith JAM, Singh M, Rosen N. Kitai H, et al. Nat Commun. 2024 Jul 19;15(1):6076. doi: 10.1038/s41467-024-50063-z. Nat Commun. 2024. PMID: 39025835 Free PMC article.
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F, Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP. Verma A, et al. Science. 2024 Jul 19;385(6706):eadj1182. doi: 10.1126/science.adj1182. Epub 2024 Jul 19. Science. 2024. PMID: 39024449
One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and understand the genetic causes of health disparities. W …
One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack …
Childhood Lead Exposure Linked to Apple Cinnamon Fruit Puree Pouches - North Carolina, June 2023-January 2024.
Napier MD, Huneycutt A, Moore C, Goforth C, Komlos M, Bryant V, Shone SM, Michael LD, Norman EH. Napier MD, et al. MMWR Morb Mortal Wkly Rep. 2024 Jul 18;73(28):622-627. doi: 10.15585/mmwr.mm7328a2. MMWR Morb Mortal Wkly Rep. 2024. PMID: 39024176 Free PMC article.
The Food and Drug Administration issued a nationwide public health advisory on October 28, 2023; 2 days later, the manufacturer issued a voluntary recall. ...
The Food and Drug Administration issued a nationwide public health advisory on October 28, 2023; 2 days later, the manufacturer issue …
Increased hepatic putrescine levels as a new potential factor related to the progression of metabolic dysfunction-associated steatotic liver disease.
Núñez-Sánchez MÁ, Martínez-Sánchez MA, Sierra-Cruz M, Lambertos A, Rico-Chazarra S, Oliva-Bolarín A, Balaguer-Román A, Yuste JE, Martínez CM, Mika A, Frutos MD, Llamoza-Torres CJ, Córdoba-Chacón J, Ramos-Molina B. Núñez-Sánchez MÁ, et al. J Pathol. 2024 Jul 18. doi: 10.1002/path.6330. Online ahead of print. J Pathol. 2024. PMID: 39022853
Despite the relatively high incidence of MASH in the population and its potential detrimental effects on human health, this liver disease is still not fully understood from a pathophysiological perspective. ...Furthermore, we found that the levels of putrescine were …
Despite the relatively high incidence of MASH in the population and its potential detrimental effects on human health, this li …
Role of WAVE3 as an of actin binding protein in the pathology of triple negative breast cancer.
Master K, El Khalki L, Bayachou M, Sossey-Alaoui K. Master K, et al. Cytoskeleton (Hoboken). 2024 Jul 18. doi: 10.1002/cm.21898. Online ahead of print. Cytoskeleton (Hoboken). 2024. PMID: 39021344 Review.
Breast cancer, a prevalent global health concern, has sparked extensive research efforts, particularly focusing on triple negative breast cancer (TNBC), a subtype lacking estrogen receptor (ER), progesterone receptor, and epidermal growth factor receptor. ...
Breast cancer, a prevalent global health concern, has sparked extensive research efforts, particularly focusing on triple negative br …
New report of Haemaphysalis longicornis (Ixodida: Ixodidae) in Mecklenburg County, Virginia from field collections.
Adams DR, Barbarin AM, Reiskind MH. Adams DR, et al. J Med Entomol. 2024 Jul 17:tjae090. doi: 10.1093/jme/tjae090. Online ahead of print. J Med Entomol. 2024. PMID: 39021151
Haemaphysalis longicornis (Neumann) was first established in New Jersey and has rapidly spread across most of the eastern United States. This tick has the potential to infest a wide variety of hosts and can reproduce quickly via parthenogenesis, presenting a new thr …
Haemaphysalis longicornis (Neumann) was first established in New Jersey and has rapidly spread across most of the eastern United S
Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer.
Zhao SG, Bootsma M, Zhou S, Shrestha R, Moreno-Rodriguez T, Lundberg A, Pan C, Arlidge C, Hawley JR, Foye A, Weinstein AS, Sjöström M, Zhang M, Li H, Chesner LN, Rydzewski NR, Helzer KT, Shi Y; West Coast Dream Team Consortium; Lynch M, Dehm SM, Lang JM, Alumkal JJ, He HH, Wyatt AW, Aggarwal R, Zwart W, Small EJ, Quigley DA, Lupien M, Feng FY. Zhao SG, et al. Nat Genet. 2024 Jul 17. doi: 10.1038/s41588-024-01826-3. Online ahead of print. Nat Genet. 2024. PMID: 39020220
Overcoming big bottlenecks in vascular regeneration.
Fantini DA, Yang G, Khanna A, Subramanian D, Phillippi JA, Huang NF. Fantini DA, et al. Commun Biol. 2024 Jul 18;7(1):876. doi: 10.1038/s42003-024-06567-x. Commun Biol. 2024. PMID: 39020071 Free PMC article. Review.
Clinical implications of Wnt pathway genetic alterations in men with advanced prostate cancer.
Broderick A, Pan E, Li J, Chu A, Hwang C, Barata PC, Cackowski FC, Labriola M, Ghose A, Bilen MA, Kilari D, Thapa B, Piero M, Graham L, Tripathi A, Garje R, Koshkin VS, Hernandez E, Dorff TB, Schweizer MT, Alva AS, McKay RR, Armstrong AJ. Broderick A, et al. Prostate Cancer Prostatic Dis. 2024 Jul 17. doi: 10.1038/s41391-024-00869-1. Online ahead of print. Prostate Cancer Prostatic Dis. 2024. PMID: 39019980
Ptycho-endoscopy on a lensless ultrathin fiber bundle tip.
Song P, Wang R, Loetgering L, Liu J, Vouras P, Lee Y, Jiang S, Feng B, Maiden A, Yang C, Zheng G. Song P, et al. Light Sci Appl. 2024 Jul 17;13(1):168. doi: 10.1038/s41377-024-01510-5. Light Sci Appl. 2024. PMID: 39019852 Free PMC article.
Type II innate lymphoid cell plasticity contributes to impaired reconstitution after allogeneic hematopoietic stem cell transplantation.
Laurie SJ, Foster JP 2nd, Bruce DW, Bommiasamy H, Kolupaev OV, Yazdimamaghani M, Pattenden SG, Chao NJ, Sarantopoulos S, Parker JS, Davis IJ, Serody JS. Laurie SJ, et al. Nat Commun. 2024 Jul 17;15(1):6000. doi: 10.1038/s41467-024-50263-7. Nat Commun. 2024. PMID: 39019846 Free PMC article.
Interestingly, murine ILC2 reconstitution post-HSCT is decreased in the presence of alloreactive T cells. Finally, peripheral blood cells from human patients with aGvHD have an altered ILC2-associated chromatin landscape compared to transplanted controls. ...
Interestingly, murine ILC2 reconstitution post-HSCT is decreased in the presence of alloreactive T cells. Finally, peripheral blood cells fr …
A longitudinal follow-up study of rescue and recovery narratives of Oklahoma City bombing responders nearly a quarter century later.
North CS, Surís A, McDonald K. North CS, et al. J Emerg Manag. 2024 May-Jun;22(3):261-274. doi: 10.5055/jem.0803. J Emerg Manag. 2024. PMID: 39017599
These workers' descriptions captured their mental toughness and their professional missions, as well as the emotional and mental health (MH) toll on their lives. CONCLUSIONS: The extreme nature of rescue and recovery work in the aftermath of terrorism suggests potential ut …
These workers' descriptions captured their mental toughness and their professional missions, as well as the emotional and mental health
West Nile Virus: A Neglected Cause of Bell's Palsy?
Al-Hashimi I, Okon E. Al-Hashimi I, et al. Cureus. 2024 Jun 16;16(6):e62486. doi: 10.7759/cureus.62486. eCollection 2024 Jun. Cureus. 2024. PMID: 39015861 Free PMC article.
The West Nile virus (WNV) is the leading cause of mosquito-borne disease in the United States. Bell's palsy (BP) is a clinical syndrome associated with viral infections, but an association with West Nile virus (WNV) is not well-described, with only two cases reporte …
The West Nile virus (WNV) is the leading cause of mosquito-borne disease in the United States. Bell's palsy (BP) is a clinical …
Measures of youth e-cigarette use: strengths, weaknesses and recommendations.
Selya A, Ruggieri M, Polosa R. Selya A, et al. Front Public Health. 2024 Jul 2;12:1412406. doi: 10.3389/fpubh.2024.1412406. eCollection 2024. Front Public Health. 2024. PMID: 39015391 Free PMC article.
This perspective discusses how to best define "e-cigarette use" among youth in a way that is relevant to individual and human health. Commonly-used definitions of youth e-cigarette use have been adapted from measures validated for tobacco cigarette smoking among adu …
This perspective discusses how to best define "e-cigarette use" among youth in a way that is relevant to individual and human heal
Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology.
de Ávila C, Gugula A, Trenk A, Intorcia AJ, Suazo C, Nolz J, Plamondon J, Khatri D, Tallant L, Caron A, Blasiak A, Serrano GE, Beach TG, Gundlach AL, Mastroeni DF. de Ávila C, et al. Biol Res. 2024 Jul 16;57(1):46. doi: 10.1186/s40659-024-00523-z. Biol Res. 2024. PMID: 39014514 Free PMC article.
Therefore, we examined the neurochemical anatomy of the human NI using markers, including the neuropeptide, relaxin-3 (RLN3), and began to explore the distribution of the NI-related RLN3 innervation of the hippocampus. ...Accumulation of phosphorylated-tau in the NI sugges …
Therefore, we examined the neurochemical anatomy of the human NI using markers, including the neuropeptide, relaxin-3 (RLN3), and beg …
A cortical surface template for human neuroscience.
Feilong M, Jiahui G, Gobbini MI, Haxby JV. Feilong M, et al. Nat Methods. 2024 Jul 16. doi: 10.1038/s41592-024-02346-y. Online ahead of print. Nat Methods. 2024. PMID: 39014074
Neuroimaging data analysis relies on normalization to standard anatomical templates to resolve macroanatomical differences across brains. Existing human cortical surface templates sample locations unevenly because of distortions introduced by inflation of the folded cortex …
Neuroimaging data analysis relies on normalization to standard anatomical templates to resolve macroanatomical differences across brains. Ex …
A survey of skin tone assessment in prospective research.
Weir VR, Dempsey K, Gichoya JW, Rotemberg V, Wong AI. Weir VR, et al. NPJ Digit Med. 2024 Jul 17;7(1):191. doi: 10.1038/s41746-024-01176-8. NPJ Digit Med. 2024. PMID: 39014060 Free PMC article. Review.
Systemic racism and Non-Hispanic Black to Non-Hispanic White disparities in infant mortality at the county level.
Ramos SZ, Rose B, Werner EF, Amutah-Onukagha N, Siegel M. Ramos SZ, et al. J Perinatol. 2024 Jul 16. doi: 10.1038/s41372-024-02048-5. Online ahead of print. J Perinatol. 2024. PMID: 39014009
OBJECTIVE: To use a novel measure of systemic racism to examine its relationship with Non-Hispanic Black (NHB) to Non-Hispanic White (NHW) racial disparities in infant mortality across U.S. counties. STUDY DESIGN: In this cross-sectional study, a composite, multi-di …
OBJECTIVE: To use a novel measure of systemic racism to examine its relationship with Non-Hispanic Black (NHB) to Non-Hispanic White (NHW) r …
From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling.
Wang H, Arulraj T, Ippolito A, Popel AS. Wang H, et al. NPJ Digit Med. 2024 Jul 16;7(1):189. doi: 10.1038/s41746-024-01188-4. NPJ Digit Med. 2024. PMID: 39014005 Free PMC article. Review.
Virtual patients and digital patients/twins are two similar concepts gaining increasing attention in health care with goals to accelerate drug development and improve patients' survival, but with their own limitations. ...
Virtual patients and digital patients/twins are two similar concepts gaining increasing attention in health care with goals to accele …
The impact of heparin and direct thrombin inhibitors on cell-penetrating polymer siRNA transfection.
Mota L, Zhu M, Tomeo JN, Recarey M, Patel N, Pradhan-Nabzdyk L, LoGerfo FW, Liang P. Mota L, et al. Gene Ther. 2024 Jul 16. doi: 10.1038/s41434-024-00460-2. Online ahead of print. Gene Ther. 2024. PMID: 39013986
Anticoagulants such as heparin, which is negatively charged and widely used in cardiovascular applications, may pose a significant barrier to effective siRNA delivery. We therefore conducted in vitro studies utilizing human smooth muscle and endothelial cells transfected w …
Anticoagulants such as heparin, which is negatively charged and widely used in cardiovascular applications, may pose a significant barrier t …
Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture.
Braga A, Chiacchiaretta M, Pellerin L, Kong D, Haydon PG. Braga A, et al. Nat Commun. 2024 Jul 16;15(1):5979. doi: 10.1038/s41467-024-50166-7. Nat Commun. 2024. PMID: 39013907 Free PMC article.
Neuronal activity undergoes significant changes during vigilance states, accompanied by an accommodation of energy demands. While the astrocyte-neuron lactate shuttle has shown that lactate is the primary energy substrate for sustaining neuronal activity in multiple brain …
Neuronal activity undergoes significant changes during vigilance states, accompanied by an accommodation of energy demands. While the …
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus.
Khurana S, King LR, Manischewitz J, Posadas O, Mishra AK, Liu D, Beigel JH, Rappuoli R, Tsang JS, Golding H. Khurana S, et al. Nat Med. 2024 Jul 16. doi: 10.1038/s41591-024-03189-y. Online ahead of print. Nat Med. 2024. PMID: 39013430
Global emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b viruses, and their transmission to dairy cattle and animals, including humans, pose a significant global public health threat. Therefore, development of effective vaccines and therapeutics aga …
Global emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b viruses, and their transmission to dairy cattle and animals …
Prevalence of alcohol use by gender and HIV status in rural Uganda.
Wynn A, Sileo KM, Schmarje Crockett K, Naigino R, Ediau M, Wanyenze RK, Kiwanuka N, Martin NK, Kiene SM. Wynn A, et al. PLoS One. 2024 Jul 16;19(7):e0303885. doi: 10.1371/journal.pone.0303885. eCollection 2024. PLoS One. 2024. PMID: 39012870 Free PMC article.
More research is needed to understand how alcohol use may increase the risks of HIV acquisition among women and to identify gender-responsive services to address harmful alcohol use and increase access to HIV testing and linkage to care for women who use harmful levels of …
More research is needed to understand how alcohol use may increase the risks of HIV acquisition among women and to identify gender-responsiv …
Cytoplasmic stirring by active carpets.
Chakrabarti B, Rachh M, Shvartsman SY, Shelley MJ. Chakrabarti B, et al. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2405114121. doi: 10.1073/pnas.2405114121. Epub 2024 Jul 16. Proc Natl Acad Sci U S A. 2024. PMID: 39012825
Building on Strong Foundations: Deploying Enhanced Replicating Effective Programs for evidence-based prevention curriculum adaptation.
Eisman AB, Palinkas LA, Koffkey C, Lafta H, Fridline J, Harvey C, Kilbourne AM. Eisman AB, et al. Transl Behav Med. 2024 Jul 15:ibae038. doi: 10.1093/tbm/ibae038. Online ahead of print. Transl Behav Med. 2024. PMID: 39011615
Schools frequently adopt new interventions for each new public health issue, but this is both time- and resource-intensive. Adversity exposure is an example of a pervasive public health issue that emerged during Coronavirus Disease 2019 (COVID-19) with notable conse …
Schools frequently adopt new interventions for each new public health issue, but this is both time- and resource-intensive. Adversity …
Teamwork and implementation of innovations in healthcare and human service settings: a systematic review.
McGuier EA, Kolko DJ, Aarons GA, Schachter A, Klem ML, Diabes MA, Weingart LR, Salas E, Wolk CB. McGuier EA, et al. Implement Sci. 2024 Jul 15;19(1):49. doi: 10.1186/s13012-024-01381-9. Implement Sci. 2024. PMID: 39010100 Free PMC article. Review.
We selected studies using quantitative, qualitative, or mixed methods to examine associations between team constructs and implementation outcomes in healthcare and human service settings. We used the Mixed Methods Appraisal Tool to assess methodological quality/risk of bia …
We selected studies using quantitative, qualitative, or mixed methods to examine associations between team constructs and implementation out …
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in T(H)17 cells.
Thakore PI, Schnell A, Huang L, Zhao M, Hou Y, Christian E, Zaghouani S, Wang C, Singh V, Singaraju A, Krishnan RK, Kozoriz D, Ma S, Sankar V, Notarbartolo S, Buenrostro JD, Sallusto F, Patsopoulos NA, Rozenblatt-Rosen O, Kuchroo VK, Regev A. Thakore PI, et al. Nat Immunol. 2024 Jul 15. doi: 10.1038/s41590-024-01901-1. Online ahead of print. Nat Immunol. 2024. PMID: 39009838
Integrating single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) and single-cell RNA sequencing (scRNA-seq), we infer self-reinforcing and mutually exclusive regulatory networks controlling different cell states and predicted transcription factors …
Integrating single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) and single-cell RNA sequencing (scRNA-seq), we in …
A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior.
Parks DF, Schneider AM, Xu Y, Brunwasser SJ, Funderburk S, Thurber D, Blanche T, Dyer EL, Haussler D, Hengen KB. Parks DF, et al. Nat Neurosci. 2024 Jul 15. doi: 10.1038/s41593-024-01715-2. Online ahead of print. Nat Neurosci. 2024. PMID: 39009836
Sleep and wake states could be classified from 10(0) to 10(1) ms of neuronal activity sampled from 100 m of brain tissue. ...This high-frequency embedding is robust to substates, sharp-wave ripples and cortical on/off states. Individual regions intermittently switch …
Sleep and wake states could be classified from 10(0) to 10(1) ms of neuronal activity sampled from 100 m of brain tissue. ...This hig …
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors.
Dong C, Gowrishankar R, Jin Y, He XJ, Gupta A, Wang H, Sayar-Atasoy N, Flores RJ, Mahe K, Tjahjono N, Liang R, Marley A, Or Mizuno G, Lo DK, Sun Q, Whistler JL, Li B, Gomes I, Von Zastrow M, Tejeda HA, Atasoy D, Devi LA, Bruchas MR, Banghart MR, Tian L. Dong C, et al. Nat Neurosci. 2024 Jul 15. doi: 10.1038/s41593-024-01697-1. Online ahead of print. Nat Neurosci. 2024. PMID: 39009835
Elevating Black fathers' experiences in the National Fatherhood Initiative: Strengths and areas for improvement of 24/7 Dad curriculum and case management services.
Voith LA, Russell KN, Withrow A, Kearney J, Xia T, Coleman D. Voith LA, et al. Fam Process. 2024 Jul 15. doi: 10.1111/famp.13036. Online ahead of print. Fam Process. 2024. PMID: 39009824
The Healthy Marriage and Responsible Fatherhood grant program is one of the most robust mechanisms supporting fatherhood programming in the United States, with the gold standard of care including fatherhood curriculum (e.g., 24/7 Dad) and case management services
The Healthy Marriage and Responsible Fatherhood grant program is one of the most robust mechanisms supporting fatherhood programming in the …
p53 at the crossroads of tumor immunity.
Efe G, Rustgi AK, Prives C. Efe G, et al. Nat Cancer. 2024 Jul 15. doi: 10.1038/s43018-024-00796-z. Online ahead of print. Nat Cancer. 2024. PMID: 39009816 Review.
MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses.
Karakus U, Sempere Borau M, Martínez-Barragán P, von Kempis J, Yildiz S, Arroyo-Fernández LM, Pohl MO, Steiger JA, Glas I, Hunziker A, García-Sastre A, Stertz S. Karakus U, et al. Nat Microbiol. 2024 Jul 15. doi: 10.1038/s41564-024-01771-1. Online ahead of print. Nat Microbiol. 2024. PMID: 39009691
Influenza A viruses (IAV) pose substantial burden on human and animal health. Avian, swine and human IAV bind sialic acid on host glycans as receptor, whereas some bat IAV require MHC class II complexes for cell entry. It is unknown how this difference evolve …
Influenza A viruses (IAV) pose substantial burden on human and animal health. Avian, swine and human IAV bind sialic ac …
Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems.
Prondzynski M, Berkson P, Trembley MA, Tharani Y, Shani K, Bortolin RH, Sweat ME, Mayourian J, Yucel D, Cordoves AM, Gabbin B, Hou C, Anyanwu NJ, Nawar F, Cotton J, Milosh J, Walker D, Zhang Y, Lu F, Liu X, Parker KK, Bezzerides VJ, Pu WT. Prondzynski M, et al. Nat Commun. 2024 Jul 15;15(1):5929. doi: 10.1038/s41467-024-50224-0. Nat Commun. 2024. PMID: 39009604 Free PMC article.
Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac disease modeling and regeneration. ...
Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac disease modeling and regeneration. ...
Single-cell total-RNA profiling unveils regulatory hubs of transcription factors.
Niu Y, Luo J, Zong C. Niu Y, et al. Nat Commun. 2024 Jul 15;15(1):5941. doi: 10.1038/s41467-024-50291-3. Nat Commun. 2024. PMID: 39009595 Free PMC article.
Overall, we demonstrate that snapTotal-seq can provide enriched information about gene regulation, especially during the transition between cell states....
Overall, we demonstrate that snapTotal-seq can provide enriched information about gene regulation, especially during the transition between …
The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis.
Wang MG, Seale P, Furman D. Wang MG, et al. NPJ Aging. 2024 Jul 15;10(1):34. doi: 10.1038/s41514-024-00159-z. NPJ Aging. 2024. PMID: 39009582 Free PMC article. Review.
Osteoarthritis (OA) is the most common form of arthritis and accounts for nearly $140 billion in annual healthcare expenditures only in the United States. Obesity, aging, and joint injury are major risk factors for OA development and progression, but the mechanisms …
Osteoarthritis (OA) is the most common form of arthritis and accounts for nearly $140 billion in annual healthcare expenditures only in the …
PRC2-AgeIndex as a universal biomarker of aging and rejuvenation.
Moqri M, Cipriano A, Simpson DJ, Rasouli S, Murty T, de Jong TA, Nachun D, de Sena Brandine G, Ying K, Tarkhov A, Aberg KA, van den Oord E, Zhou W, Smith A, Mackall C, Gladyshev VN, Horvath S, Snyder MP, Sebastiano V. Moqri M, et al. Nat Commun. 2024 Jul 16;15(1):5956. doi: 10.1038/s41467-024-50098-2. Nat Commun. 2024. PMID: 39009581 Free PMC article.
Beta activity in human anterior cingulate cortex mediates reward biases.
Xiao J, Adkinson JA, Myers J, Allawala AB, Mathura RK, Pirtle V, Najera R, Provenza NR, Bartoli E, Watrous AJ, Oswalt D, Gadot R, Anand A, Shofty B, Mathew SJ, Goodman WK, Pouratian N, Pitkow X, Bijanki KR, Hayden B, Sheth SA. Xiao J, et al. Nat Commun. 2024 Jul 15;15(1):5528. doi: 10.1038/s41467-024-49600-7. Nat Commun. 2024. PMID: 39009561 Free PMC article.
Time-scale invariant contingency yields one-shot reinforcement learning despite extremely long delays to reinforcement.
Gallistel CR, Shahan TA. Gallistel CR, et al. Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2405451121. doi: 10.1073/pnas.2405451121. Epub 2024 Jul 15. Proc Natl Acad Sci U S A. 2024. PMID: 39008663 Free article.
By leveraging metric temporal information, our solution obviates the need for windows of associability, exponentially decaying eligibility traces, microstimuli, or distributions over Bayesian belief states. Its three equations have no free parameters; they predict one-shot …
By leveraging metric temporal information, our solution obviates the need for windows of associability, exponentially decaying eligibility t …
Digital Footprints of Obesity Treatment: GLP-1 Receptor Agonists and the Health Equity Divide.
Azizi Z, Rodriguez F, Assimes TL. Azizi Z, et al. Circulation. 2024 Jul 16;150(3):171-173. doi: 10.1161/CIRCULATIONAHA.124.069680. Epub 2024 Jul 15. Circulation. 2024. PMID: 39008562 Review.
Given the high cost of GLP-1 agonists, a critical question arises: Will this disparity in medication accessibility exacerbate the global health equity gap in obesity treatment? This viewpoint explores strategies to address the health equity gap exacerbated by this e …
Given the high cost of GLP-1 agonists, a critical question arises: Will this disparity in medication accessibility exacerbate the global …
Equitable Care for Hypertension: Blood Pressure and Patient-Reported Outcomes of the RICH LIFE Cluster Randomized Trial.
Cooper LA, Marsteller JA, Carson KA, Dietz KB, Boonyasai RT, Alvarez C, Crews DC, Dennison Himmelfarb CR, Ibe CA, Lubomski L, Miller ER 3rd, Wang NY, Avornu GD, Brown D, Hickman D, Simmons M, Apfel Stein A, Yeh HC; RICH LIFE Project Investigators. Cooper LA, et al. Circulation. 2024 Jul 16;150(3):230-242. doi: 10.1161/CIRCULATIONAHA.124.069622. Epub 2024 Jul 15. Circulation. 2024. PMID: 39008556 Clinical Trial.
SCP included BP measurement standardization, audit and feedback, and equity-leadership training. CC/SC added roles to address social or medical needs. Primary outcomes were BP control and patient activation at 12 months. ...
SCP included BP measurement standardization, audit and feedback, and equity-leadership training. CC/SC added roles to address social
Sequencing of Kaposi's Sarcoma Herpesvirus (KSHV) genomes from persons of diverse ethnicities and provenances with KSHV-associated diseases demonstrate multiple infections, novel polymorphisms, and low intra-host variance.
Marshall VA, Cornejo Castro EM, Goodman CA, Labo N, Liu I, Fisher NC, Moore KN, Nair A, Immonen T, Keele BF, Polizzotto MN, Uldrick TS, Mu Y, Saswat T, Krug LT, McBride KM, Lurain K, Ramaswami R, Yarchoan R, Whitby D. Marshall VA, et al. PLoS Pathog. 2024 Jul 15;20(7):e1012338. doi: 10.1371/journal.ppat.1012338. Online ahead of print. PLoS Pathog. 2024. PMID: 39008527 Free article.
Health-related quality of life in ethnically diverse Black prostate cancer survivors: a convergent parallel mixed-methods approach.
Ogunsanya ME, Kaninjing E, Ellis TN, Morton DJ, McIntosh AG, Zhao J, Dickey SL, Kendzor DE, Dwyer K, Young ME, Odedina FT. Ogunsanya ME, et al. Qual Life Res. 2024 Jul 15. doi: 10.1007/s11136-024-03718-9. Online ahead of print. Qual Life Res. 2024. PMID: 39008143
PURPOSE: This study examined the health-related quality of life (HRQoL) among ethnically diverse Black men (BM) with prostate cancer (CaP) in the United States. ...QoL for all men was assessed using The Functional Assessment Cancer Therapy-Prostate (FACT-P) m …
PURPOSE: This study examined the health-related quality of life (HRQoL) among ethnically diverse Black men (BM) with prostate cancer …
Multi-year analysis of the global preclinical antibacterial pipeline: trends and gaps.
Gigante V, Alm RA, Melchiorri D, Rocke T, Arias CA, Czaplewski L, Fernandes P, Franceschi F, Harbarth S, Kozlov R, Lienhardt C, Ohmagari N, Ogilvie LA, Paul M, Rex JH, Silver LL, Spigelman M, Sati H, Cameron AM. Gigante V, et al. Antimicrob Agents Chemother. 2024 Jul 15:e0053524. doi: 10.1128/aac.00535-24. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 39007560 Free article. Review.
Antimicrobial resistance (AMR) is a major global health threat estimated to have caused the deaths of 1.27 million people in 2019, which is more than HIV/AIDS and malaria deaths combined. ...To understand the status of upstream antibiotic development and the challenges fac …
Antimicrobial resistance (AMR) is a major global health threat estimated to have caused the deaths of 1.27 million people in 2019, wh …
Anticipating the Next Pandemic.
Meissner HC, Kapogiannis BG, Wolfe DN. Meissner HC, et al. N Engl J Med. 2024 Jul 18;391(3):196-199. doi: 10.1056/NEJMp2403598. Epub 2024 Jul 13. N Engl J Med. 2024. PMID: 39007537 No abstract available.
"It's not the 'being trans,' it's everything around that": Trans Community Perspectives for Suicide Prevention.
Kirby AV, Krebs E, Hiatt L, Docherty A, Mihalopoulos NL, Keeshin BR, Peifer E, Craker M, Staley M, Bakian AV, Coon H. Kirby AV, et al. Bull Appl Transgend Stud. 2024 Summer;3(1-2):69-97. doi: 10.57814/ec38-hh59. Epub 2024 Jun 28. Bull Appl Transgend Stud. 2024. PMID: 39007095 Free PMC article.
Suicide prevention efforts are needed that address the most important issues to the trans community. In this qualitative study conducted in the United States in 2021, we aimed to broadly explore trans community member perspectives on suicidality and suicide preventi …
Suicide prevention efforts are needed that address the most important issues to the trans community. In this qualitative study conducted in …
Comparison Between Disability, Physical Performance, and Other Biopsychosocial Factors in Full-Duty Career Firefighters Working With and Without Current Low Back Pain.
Mayer JM, Verna JL, Hubka M, Phelps B, Wolfinger C, Lane CL. Mayer JM, et al. Cureus. 2024 Jun 11;16(6):e62189. doi: 10.7759/cureus.62189. eCollection 2024 Jun. Cureus. 2024. PMID: 39006584 Free PMC article.
CONCLUSION: Nearly one-fifth of full-duty career firefighters without documented work restrictions reported having current LBP, and these individuals had deficits in several modifiable biopsychosocial factors across five health domains. These findings can help guide future …
CONCLUSION: Nearly one-fifth of full-duty career firefighters without documented work restrictions reported having current LBP, and these in …
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.
Strom NI, Verhulst B, Bacanu SA, Cheesman R, Purves KL, Gedik H, Mitchell BL, Kwong AS, Faucon AB, Singh K, Medland S, Colodro-Conde L, Krebs K, Hoffmann P, Herms S, Gehlen J, Ripke S, Awasthi S, Palviainen T, Tasanko EM, Peterson RE, Adkins DE, Shabalin AA, Adams MJ, Iveson MH, Campbell A, Thomas LF, Winsvold BS, Drange OK, Børte S, Ter Kuile AR, Nguyen TH, Meier SM, Corfield EC, Hannigan L, Levey DF, Czamara D, Weber H, Choi KW, Pistis G, Couvy-Duchesne B, Van der Auwera S, Teumer A, Karlsson R, Garcia-Argibay M, Lee D, Wang R, Bjerkeset O, Stordal E, Bäckmann J, Salum GA, Zai CC, Kennedy JL, Zai G, Tiwari AK, Heilmann-Heimbach S, Schmidt B, Kaprio J, Kennedy MM, Boden J, Havdahl A, Middeldorp CM, Lopes FL, Akula N, McMahon FJ, Binder EB, Fehm L, Ströhle A, Castelao E, Tiemeier H, Stein DJ, Whiteman D, Olsen C, Fuller Z, Wang X, Wray NR, Byrne EM, Lewis G, Timpson NJ, Davis LK, Hickie IB, Gillespie NA, Milani L, Schumacher J, Woldbye DP, Forstner AJ, Nöthen MM, Hovatta I, Horwood J, Copeland WE, Maes HH, McIntosh AM, Andreassen OA, Zwart JA, Mors O, Børglum AD, Mortensen PB, Ask H, Reichborn-Kjennerud T, Najman JM, Stein MB, Gelernter J, Milaneschi Y, Penninx BW, Boomsma DI, Mar… See abstract for full author list ➔ Strom NI, et al. medRxiv [Preprint]. 2024 Jul 5:2024.07.03.24309466. doi: 10.1101/2024.07.03.24309466. medRxiv. 2024. PMID: 39006447 Free PMC article. Preprint.
A collective agenda: A qualitative study on Exercise is Medicine® On Campus gold-level institutions.
McAvoy CR, Dahl AA, Hoon Lim J, Bauer P, Brunner Huber LR. McAvoy CR, et al. Prev Med Rep. 2024 Jun 9;44:102785. doi: 10.1016/j.pmedr.2024.102785. eCollection 2024 Aug. Prev Med Rep. 2024. PMID: 39006187 Free PMC article.
For Gold recognition, schools must incorporate routine physical activity assessments into their health system, ultimately connecting healthcare providers with health/fitness professionals (HFPs, e.g., campus recreation professionals, kinesiology professors). ...METH …
For Gold recognition, schools must incorporate routine physical activity assessments into their health system, ultimately connecting …
Sex differences in heat stress vulnerability among middle-aged and older adults (PSU HEAT project).
Leach OK, Cottle RM, Fisher KG, Wolf ST, Kenney WL. Leach OK, et al. Am J Physiol Regul Integr Comp Physiol. 2024 Jul 15. doi: 10.1152/ajpregu.00114.2024. Online ahead of print. Am J Physiol Regul Integr Comp Physiol. 2024. PMID: 39005081
Individuals over the age of 65 are the most vulnerable population during severe environmental heat events, experiencing worse health outcomes than any other age cohort. The risk is greater in older women than in age-matched men; however, whether that reflects a greater sus …
Individuals over the age of 65 are the most vulnerable population during severe environmental heat events, experiencing worse health
Surveillance of PFAS in sludge and biosolids at 12 water resource recovery facilities.
Oza S, Bell KY, Xu Z, Wang Y, Wells MJM, Norton JW Jr, Winchell LJ, Huang Q, Li H. Oza S, et al. J Environ Qual. 2024 Jul 14. doi: 10.1002/jeq2.20595. Online ahead of print. J Environ Qual. 2024. PMID: 39004957
Given recent advances in measurement of PFAS, documentation of the range of concentrations in pre-stabilized sludge and stabilized biosolids is critical to evaluating treatment best practices and assessing potential human health and ecological risks. In this study, …
Given recent advances in measurement of PFAS, documentation of the range of concentrations in pre-stabilized sludge and stabilized biosolids …
Experiences participating in federal nutrition assistance programs during the early months of the COVID-19 pandemic: an investigation in Vermont.
Spence EH, Niles MT, Bertmann F, Belarmino EH. Spence EH, et al. Nutr J. 2024 Jul 15;23(1):74. doi: 10.1186/s12937-024-00963-z. Nutr J. 2024. PMID: 39004722 Free PMC article.
BACKGROUND: Federal nutrition assistance programs serve as safety nets for many American households, and participation has been linked to increased food security and, in some instances, improved diet quality and mental health outcomes. The COVID-19 pandemic brought new and …
BACKGROUND: Federal nutrition assistance programs serve as safety nets for many American households, and participation has been linked to in …
PHF6 suppresses self-renewal of leukemic stem cells in AML.
Jalnapurkar SS, Pawar AS, George SS, Antony C, Somers P, Grana J, Feist VK, Gurbuxani S, Paralkar VR. Jalnapurkar SS, et al. Leukemia. 2024 Jul 14. doi: 10.1038/s41375-024-02340-5. Online ahead of print. Leukemia. 2024. PMID: 39004675
We find that Phf6 loss expands the LIC-e population and skews its transcriptome to a more stem-like state; concordant transcriptome shifts are also observed on PHF6 knockout in a human AML cell line and in PHF6 mutant patient samples from the BEAT AML dataset. ...
We find that Phf6 loss expands the LIC-e population and skews its transcriptome to a more stem-like state; concordant transcriptome shifts a …
"If it has happened once, it can happen again". The impact of previous pregnancy loss on anxious women's ongoing pregnancies: A qualitative study from Pakistan.
Maryam H, Liaqat R, Rowther AA, Atiq M, Nazir H, Malik A, Rahman A, Surkan PJ, Atif N. Maryam H, et al. Midwifery. 2024 Jun 28;137:104087. doi: 10.1016/j.midw.2024.104087. Online ahead of print. Midwifery. 2024. PMID: 39003932
FINDINGS: The findings revealed several factors influencing participants' well-being during pregnancies that resulted in a loss, such as unsupportive and abusive environments, unintended pregnancies, certain superstitious beliefs, poor health, and lack of access to quality …
FINDINGS: The findings revealed several factors influencing participants' well-being during pregnancies that resulted in a loss, such as uns …
Unmet Surgical Need among Adults in A Mixed Urban-Rural Community in Nigeria: A Survey of 1,993 Adults Using the Sosas Survey Tool.
Bankole OB, Makanjuola A, Alabi EO, Odugbemi TO, Abazie O, Ademuyiwa IY, Okusanya B, Onwuka A, Smith ER, Tran T, Gupta S, Ots R, Harrison EM, Poenaru D, Elebute OA, Seyi-Olajide JO, Ladipo-Ajayi O, Alakaloko FM, Bode CO, Nwomeh BN, Ademuyiwa AO. Bankole OB, et al. West Afr J Med. 2024 Apr 30;41(4):436-451. West Afr J Med. 2024. PMID: 39003518
However, such community-based prevalence studies are uncommon in low- and middle-income countries including Nigeria. Allocation of resources and prioritization of health care needs by policy makers require data from such community-based studies to be meaningful and sustain …
However, such community-based prevalence studies are uncommon in low- and middle-income countries including Nigeria. Allocation of resources …
Association of systemic and demographic risk factors with prevalence of retinopathy in US adults with prediabetes.
Bynoe K, Wang J, Sachdeva MM. Bynoe K, et al. Eye (Lond). 2024 Jul 13. doi: 10.1038/s41433-024-03227-6. Online ahead of print. Eye (Lond). 2024. PMID: 39003432
SUBJECTS/METHODS: A group of 2098 participants aged 40 years with available HbA1c and gradable retinal images from the National Health and Nutrition Examination Survey 2005-2008 were included in this retrospective cross-sectional analysis. ...
SUBJECTS/METHODS: A group of 2098 participants aged 40 years with available HbA1c and gradable retinal images from the National Health
Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs.
Garibyan M, Hoffman T, Makaske T, Do SK, Wu Y, Williams BA, March AR, Cho N, Pedroncelli N, Lima RE, Soto J, Jackson B, Santoso JW, Khademhosseini A, Thomson M, Li S, McCain ML, Morsut L. Garibyan M, et al. Nat Commun. 2024 Jul 13;15(1):5891. doi: 10.1038/s41467-024-50126-1. Nat Commun. 2024. PMID: 39003263 Free PMC article.
DropBlot: single-cell western blotting of chemically fixed cancer cells.
Liu Y, Herr AE. Liu Y, et al. Nat Commun. 2024 Jul 13;15(1):5888. doi: 10.1038/s41467-024-50046-0. Nat Commun. 2024. PMID: 39003254 Free PMC article.
Relevant to biorepositories, DropBlot profiled targets retrieved from human-derived breast tumor specimens archived for six years, offering a workflow for single-cell protein-biomarker analysis of sparing biospecimens....
Relevant to biorepositories, DropBlot profiled targets retrieved from human-derived breast tumor specimens archived for six years, of …
Impact of the COVID-19 Pandemic on Youth Substance Use and Substance-Related Risk Factors and Outcomes: Implications for Prevention, Treatment, and Policy.
Hammond CJ, Van Eck K, Adger H. Hammond CJ, et al. Pediatr Clin North Am. 2024 Aug;71(4):653-669. doi: 10.1016/j.pcl.2024.05.002. Epub 2024 Jun 11. Pediatr Clin North Am. 2024. PMID: 39003008 Review.
Youth substance use and substance use disorders (SUD) are major public health issues associated with significant societal cost. The coronavirus SARS-CoV-2 (COVID-19) pandemic and pandemic-related lockdowns, school closures, and social distancing dramatically impacte …
Youth substance use and substance use disorders (SUD) are major public health issues associated with significant societal cost. The c …
ACPM Position Statement: Air Pollution & Environmental Justice.
Rj F, Lj S, Sa L, DE S, S P, Dw N. Rj F, et al. Am J Prev Med. 2024 Jul 11:S0749-3797(24)00232-0. doi: 10.1016/j.amepre.2024.07.003. Online ahead of print. Am J Prev Med. 2024. PMID: 39002887
Differential air pollution exposures between white and non-white communities are significant components of environmental injustices. Even during the COVID-19 lockdown, when the United States experienced significant decreases in polluting activities, these difference …
Differential air pollution exposures between white and non-white communities are significant components of environmental injustices. Even du …
Bridging the Gap: The Need to Implement Dietary Guidance to Address Cardiovascular Health.
Brown AGM, Adas S, de Jesus J, Farmer N, Fisher R, Pratt CA. Brown AGM, et al. Nutrients. 2024 Jul 3;16(13):2125. doi: 10.3390/nu16132125. Nutrients. 2024. PMID: 38999873 Free PMC article. Review.
Cardiovascular disease (CVD) is the leading cause of death in the U.S. and globally. Research demonstrates that diet is a leading contributor to the development of CVD, its prevention and management, and the overall promotion of cardiovascular health. ...It h …
Cardiovascular disease (CVD) is the leading cause of death in the U.S. and globally. Research demonstrates that diet is a lead …
An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score.
Reddy YNV, Carter RE, Sundaram V, Kaye DM, Handoko ML, Tedford RJ, Andersen MJ, Sharma K, Obokata M, Verbrugge FH, Borlaug BA. Reddy YNV, et al. Nat Med. 2024 Jul 12. doi: 10.1038/s41591-024-03140-1. Online ahead of print. Nat Med. 2024. PMID: 38997608
Model-based probabilities were also associated with increased risk of HF hospitalization or death among patients from the Mayo Clinic (n = 790) and a US national cohort across the Veteran Affairs health system (n = 3076, 110 women). Using the HFpEF-ABA score, rapid and eff …
Model-based probabilities were also associated with increased risk of HF hospitalization or death among patients from the Mayo Clinic (n = 7 …
Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder.
Provenza NR, Reddy S, Allam AK, Rajesh SV, Diab N, Reyes G, Caston RM, Katlowitz KA, Gandhi AD, Bechtold RA, Dang HQ, Najera RA, Giridharan N, Kabotyanski KE, Momin F, Hasen M, Banks GP, Mickey BJ, Kious BM, Shofty B, Hayden BY, Herron JA, Storch EA, Patel AB, Goodman WK, Sheth SA. Provenza NR, et al. Nat Med. 2024 Jul 12. doi: 10.1038/s41591-024-03125-0. Online ahead of print. Nat Med. 2024. PMID: 38997607
Keypoint-MoSeq: parsing behavior by linking point tracking to pose dynamics.
Weinreb C, Pearl JE, Lin S, Osman MAM, Zhang L, Annapragada S, Conlin E, Hoffmann R, Makowska S, Gillis WF, Jay M, Ye S, Mathis A, Mathis MW, Pereira T, Linderman SW, Datta SR. Weinreb C, et al. Nat Methods. 2024 Jul;21(7):1329-1339. doi: 10.1038/s41592-024-02318-2. Epub 2024 Jul 12. Nat Methods. 2024. PMID: 38997595 Free PMC article.
Here we present keypoint-MoSeq, a machine learning-based platform for identifying behavioral modules ('syllables') from keypoint data without human supervision. Keypoint-MoSeq uses a generative model to distinguish keypoint noise from behavior, enabling it to identify syll …
Here we present keypoint-MoSeq, a machine learning-based platform for identifying behavioral modules ('syllables') from keypoint data withou …
Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA.
Reautschnig P, Fruhner C, Wahn N, Wiegand CP, Kragness S, Yung JF, Hofacker DT, Fisk J, Eidelman M, Waffenschmidt N, Feige M, Pfeiffer LS, Schulz AE, Füll Y, Levanon EY, Mandel G, Stafforst T. Reautschnig P, et al. Nat Biotechnol. 2024 Jul 12. doi: 10.1038/s41587-024-02313-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38997581
Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection.
Samaddar S, Rolandelli A, O'Neal AJ, Laukaitis-Yousey HJ, Marnin L, Singh N, Wang X, Butler LR, Rangghran P, Kitsou C, Cabrera Paz FE, Valencia L, R Ferraz C, Munderloh UG, Khoo B, Cull B, Rosche KL, Shaw DK, Oliver J, Narasimhan S, Fikrig E, Pal U, Fiskum GM, Polster BM, Pedra JHF. Samaddar S, et al. Nat Microbiol. 2024 Jul 12. doi: 10.1038/s41564-024-01756-0. Online ahead of print. Nat Microbiol. 2024. PMID: 38997520
The blacklegged tick, Ixodes scapularis, is the predominant arthropod vector in the United States and is responsible for transmitting several human pathogens, including the Lyme disease spirochete Borrelia burgdorferi and the obligate intracellular rickettsia …
The blacklegged tick, Ixodes scapularis, is the predominant arthropod vector in the United States and is responsible for trans …