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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 4
1948 3
1949 3
1950 3
1951 11
1952 9
1953 6
1954 12
1955 7
1956 5
1957 14
1958 14
1959 17
1960 19
1961 19
1962 23
1963 46
1964 61
1965 70
1966 180
1967 215
1968 214
1969 200
1970 209
1971 186
1972 199
1973 231
1974 297
1975 368
1976 408
1977 603
1978 982
1979 1194
1980 15685
1981 33527
1982 34552
1983 35009
1984 36722
1985 37425
1986 38598
1987 39963
1988 41078
1989 42719
1990 44831
1991 46118
1992 46703
1993 47438
1994 48934
1995 49321
1996 49509
1997 49844
1998 50837
1999 52358
2000 54943
2001 56287
2002 59380
2003 63599
2004 71267
2005 77913
2006 86523
2007 93100
2008 103260
2009 110072
2010 119464
2011 128537
2012 133194
2013 138277
2014 139639
2015 140804
2016 136229
2017 131688
2018 134219
2019 136120
2020 148763
2021 156017
2022 143521
2023 144665
2024 138890
2025 129758
2026 30554
2028 1

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3,509,601 results

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Fear of falling is associated with physical functioning, activity performance, and participation in individuals with multiple sclerosis.
Abou L, Kim J, McCloskey C, Wernimont C, Kratz AL. Abou L, et al. PM R. 2026 Apr 15. doi: 10.1002/pmrj.70131. Online ahead of print. PM R. 2026. PMID: 41986967
Measures of participation included PROMIS ability to participate in social roles and activities (SRAs) and Community Participation Indicators-Control subscale. ...
Measures of participation included PROMIS ability to participate in social roles and activities (SRAs) and Community Participation In …
Deep single-cell decoding of human pancreatic islets reveals T2D beta-cell gene expression defects.
Bandesh K, Motakis E, Nargund S, Kursawe R, Selvam V, Ansarullah, Bhuiyan RM, Eryilmaz GN, Willett AM, White JK, Krishnan SN, Spracklen CN, Ucar D, Stitzel ML. Bandesh K, et al. EMBO J. 2026 Apr 15. doi: 10.1038/s44318-026-00744-w. Online ahead of print. EMBO J. 2026. PMID: 41986506 Free article.
Pancreatic islets maintain glucose homeostasis through coordinated action of endocrine and affiliate cell types and are central to type 2 diabetes (T2D) genetics and pathophysiology. Our understanding of robust human islet cell type-specific alterations in T2D remains limi …
Pancreatic islets maintain glucose homeostasis through coordinated action of endocrine and affiliate cell types and are central to type 2 di …
SARS-CoV-2 vaccination and infection elicit cross-neutralizing responses against clade 3 and 4 sarbecoviruses.
Schmidt SD, Subramanian R, Basappa M, Carroll R, Rexhepaj M, Posavad CM, Liao JA, Bohl JA, Chowdhury A, Spaulding AB, Lin BC, Castro M, Koup RA, Serebryannyy LA, Douek DC. Schmidt SD, et al. Nat Commun. 2026 Apr 16. doi: 10.1038/s41467-026-71662-y. Online ahead of print. Nat Commun. 2026. PMID: 41986366 Free article.
Two sarbecoviruses, SARS-CoV-1 and SARS-CoV-2 that engage ACE2 through their receptor-binding domains, have caused major human outbreaks. The pandemic potential of sarbecoviruses has prompted the discovery and classification of bat and other zoonotic sarbecoviruses that ar …
Two sarbecoviruses, SARS-CoV-1 and SARS-CoV-2 that engage ACE2 through their receptor-binding domains, have caused major human outbre …
Design and In Vivo Validation of a Constant-Flow Ventilation Circuit for Tissue Stabilization During Intravital Imaging of the Lungs.
Jardim-Neto AC, Perlman CE. Jardim-Neto AC, et al. Ann Biomed Eng. 2026 Apr 15. doi: 10.1007/s10439-026-04031-x. Online ahead of print. Ann Biomed Eng. 2026. PMID: 41986820
CONCLUSION: This technique could enable new research investigations, e.g., of in vivo microvascular/alveolar mechanics without vacuum artifacts or cardiopulmonary coupling, and could potentially have clinical applications, e.g., protection against ventilation-induced lung …
CONCLUSION: This technique could enable new research investigations, e.g., of in vivo microvascular/alveolar mechanics without vacuum …
The Association Between Shared Decision-Making and Child Health in the General Pediatric Population.
Cohen A, Michelson KN, Macy ML, Heard-Garris N, Kan K. Cohen A, et al. Matern Child Health J. 2026 Apr 15. doi: 10.1007/s10995-026-04251-6. Online ahead of print. Matern Child Health J. 2026. PMID: 41986782
OBJECTIVE: Shared decision-making (SDM) is a decision-making approach that aims to enhance collaboration between patients and providers. SDM is associated with improved health outcomes and decreased healthcare expenditure among children with special health care need …
OBJECTIVE: Shared decision-making (SDM) is a decision-making approach that aims to enhance collaboration between patients and providers. SDM …
Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na(+) channel dynamics in human neurons.
Cui L, Kurganov E, Hawes D, Hornauer P, Lin R, Wang Y, Hierlemann A, Sheng M, Nehme R, Pan JQ. Cui L, et al. Mol Psychiatry. 2026 Apr 15. doi: 10.1038/s41380-026-03587-3. Online ahead of print. Mol Psychiatry. 2026. PMID: 41986745
In this study, we investigate the functional consequences of XPO7 loss of function (LoF) in human induced pluripotent stem cell (iPSC)-derived neurons, focusing on its role as a schizophrenia risk gene identified through recent large-scale exome sequencing analyses. ...
In this study, we investigate the functional consequences of XPO7 loss of function (LoF) in human induced pluripotent stem cell (iPSC …
Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers.
Adkinson BD, Rosenblatt M, Sun H, Dadashkarimi J, Tejavibulya L, Horien C, Westwater ML, Rodriguez RX, Noble S, Scheinost D. Adkinson BD, et al. Nat Hum Behav. 2026 Apr 15. doi: 10.1038/s41562-026-02447-y. Online ahead of print. Nat Hum Behav. 2026. PMID: 41986741
A central objective in human neuroimaging is to understand the neurobiology underlying cognition and mental health. ...
A central objective in human neuroimaging is to understand the neurobiology underlying cognition and mental health. ...
Rapid expansion of genotype D1.1 A(H5N1) influenza viruses in wild birds across North America during the 2024 migratory season.
Harrington WN, Signore A, Kercher L, Giacinti JA, Kandeil A, Ahlstrom CA, Bevins S, Crossley B, Eure K, Fabrizio TP, Jeevan T, Lenoch J, Nolting JM, Rejmanek D, Stallknecht D, Bollinger T, Buck EJ, Carter D, Cohen BS, Dilione KE, Feddersen JC, Franks J, Goldsmith D, Highway CJ, Himsworth C, Holmes LP, Jardine C, Jahid MJ, Link P, Miller L, Nemeth NM, Owsiany M, Pybus M, Scott LC, Sharp C, Smith L, Steelman NJ, Stevens B, Berhane Y, Torchetti M, Ramey AM, Poulson R, Webby RJ. Harrington WN, et al. Nat Med. 2026 Apr 15. doi: 10.1038/s41591-026-04300-1. Online ahead of print. Nat Med. 2026. PMID: 41986738
Their expansion coincided with detections in other hosts, including 17 human cases, 4 of which were severe or fatal. None of the mammalian-adaptive markers detected in human cases were found in wild bird viruses, and candidate vaccine viruses retained antigenic cros …
Their expansion coincided with detections in other hosts, including 17 human cases, 4 of which were severe or fatal. None of the mamm …
Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes.
Li C, Richards SM, Quinn G, Abedini A, Zhu M, Verma T, Mohandes S, Pitts R, Barros V, Qiu X, Shin T, Loureiro JJ, Finkel N, Surapaneni A, Coresh J, Grams ME, Karihaloo A, Li H, Verma A, Ritchie M, Rader DJ; Penn Medicine BioBank; Dietrich WF, Jennings LL, Susztak K. Li C, et al. Nat Med. 2026 Apr 15. doi: 10.1038/s41591-026-04337-2. Online ahead of print. Nat Med. 2026. PMID: 41986737
An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration.
Honey MIJ, Hok-A-Hin YS, Thijssen EH, Cousins KAQ, van der Weijden B, In 't Veld L, Stoops E, de Boer SCM, Duits FH, de Houwer JFH, Morrema THJ, Alcolea D, Illán-Gala I, Fortea J, Lleó A, Boxer AL, Irwin DJ, Lee EB, Shaw L, McMillan CT, Wolk DA, Hoozemans JJM, van der Flier WM, van der Ende E, Seelaar H, Verberk IMW, Gan L, Pijnenburg Y, Teunissen CE. Honey MIJ, et al. Nat Med. 2026 Apr 15. doi: 10.1038/s41591-026-04341-6. Online ahead of print. Nat Med. 2026. PMID: 41986736
Structure-centric searching enables global mapping of the public metabolome.
El Abiead Y, Seo JI, Charron-Lamoureux V, Strobel M, Gonçalves Nunes WD, Zhao HN, Kvitne KE, Zuffa S, Mannochio-Russo H, Gouda H, Bez C, Patan A, Xing S, Zemlin J, Mohany I, Agongo J, Caraballo Rodriguez AM, Burnett LA, Deleray V, Pakkir Shah AK, Kalinski JC, Petras D, Alygizakis N, Carver J, Yurekten O, Payne T, Fahy E, Subramaniam S, Vizcaíno JA, Wang M, Dorrestein PC. El Abiead Y, et al. Nat Biotechnol. 2026 Apr 15. doi: 10.1038/s41587-026-03082-8. Online ahead of print. Nat Biotechnol. 2026. PMID: 41986697
Inducible, split base editors for in vivo cancer functional genomics.
Ren D, Wang S, Yamada K, Liu Y, Hapke R, Alpsoy A, Ho Y, Zhang C, Lan Y, Zhang S, Milazzo JP, Lohia R, Berríos KN, Li Y, Weber EW, Li Q, Vakoc CR, Minn AJ, Kohli RM, Shi J. Ren D, et al. Nat Biotechnol. 2026 Apr 15. doi: 10.1038/s41587-026-03077-5. Online ahead of print. Nat Biotechnol. 2026. PMID: 41986696
KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9.
Belle R, Bukowski JP, Schiller R, Cutler R, Salah E, Dawber RS, Tumber A, Bonnici J, Kindrick JD, Serrano L, Rabe P, Johansson C, Ruchaud MH, Hopkinson RJ, Figg WD Sr, Brennan PE, Mole DR, Sidoli S, Kawamura A, Schofield CJ. Belle R, et al. Nat Chem. 2026 Apr 15. doi: 10.1038/s41557-026-02112-x. Online ahead of print. Nat Chem. 2026. PMID: 41986689
Designer indicators for two-photon recording of subthreshold voltage dynamics.
Land MA, Galdamez M, Villette V, Zhu J, Lu X, Marosi M, Yang S, Foran G, McDonald AJ, Dong X, Zaabout E, Liu H, Liu Z, Colbert KL, Lai S, Shorey M, Lourdiane ASG, Ayon A, Bradley J, Mailhes-Hamon C, Natan RG, Zhong J, Kroeger R, Law RG, Hakam N, Smith CL, Hu M, Tabb S, Bathellier B, Dudok B, Ji N, Bourdieu L, Reimer J, St-Pierre F. Land MA, et al. Nat Methods. 2026 Apr 15. doi: 10.1038/s41592-026-03043-8. Online ahead of print. Nat Methods. 2026. PMID: 41986688
By enabling sensitive reporting of subthreshold voltage dynamics, JEDI3 indicators open previously unexplored avenues for dissecting neural information processing in health and disease....
By enabling sensitive reporting of subthreshold voltage dynamics, JEDI3 indicators open previously unexplored avenues for dissecting neural …
A series of spontaneously blinking dyes for super-resolution microscopy.
Holland KL, Plutkis SE, English BP, Daugird TA, Sau A, Grimm JB, Zheng Q, Sharma A, Dave S, Schmidt A, Rahman F, Xie L, Dong P, Tkachuk AN, Brown TA, Singer RH, Liu ZJ, Musser SM, Legant WR, Galbraith CG, Lavis LD. Holland KL, et al. Nat Methods. 2026 Apr 15. doi: 10.1038/s41592-026-03062-5. Online ahead of print. Nat Methods. 2026. PMID: 41986687
Long-term outcomes in adults born preterm with symptomatic patent ductus arteriosus.
Joseph A, Chandra A, Barton GP, Sanchez-Solano NJ, Berry JD, Goss KN. Joseph A, et al. J Perinatol. 2026 Apr 15. doi: 10.1038/s41372-026-02685-y. Online ahead of print. J Perinatol. 2026. PMID: 41986666
STUDY DESIGN: Young adults born preterm ( 32 weeks gestation; n = 107) were recruited from the Parkland Health Neonatal Intensive Care Unit (NICU) Registry and compared based on presence of symptomatic PDA during their NICU stay (n = 23 with PDA), defined as clinical evide …
STUDY DESIGN: Young adults born preterm ( 32 weeks gestation; n = 107) were recruited from the Parkland Health Neonatal Intensive Car …
Distinct infant resistome trajectories shaped by country income and geography revealed through global metagenomics reanalysis.
Luchen CC, Piedade GJ, Chibuye M, Simuyandi M, Chisenga CC, Chilengi R, Bosomprah S, Schultsz C, Mende DR, Harris VC. Luchen CC, et al. NPJ Antimicrob Resist. 2026 Apr 15;4(1):24. doi: 10.1038/s44259-026-00194-8. NPJ Antimicrob Resist. 2026. PMID: 41986657
Antimicrobial resistance (AMR) costs lives, diminishes antimicrobial effectiveness and increases health care costs. We conducted a re-analysis of pooled fecal metagenomes from individual participants to characterise AMR gene (ARG) distributions in 0-2 year-old healthy infa …
Antimicrobial resistance (AMR) costs lives, diminishes antimicrobial effectiveness and increases health care costs. We conducted a re …
Predicting post-stroke functional outcome using explainable machine learning and integrated data.
Olsson J, Stanne TM, Andersson B, Jern C. Olsson J, et al. Sci Rep. 2026 Apr 15;16(1):12462. doi: 10.1038/s41598-026-47814-x. Sci Rep. 2026. PMID: 41986523
The MLP achieved the highest precision-recall performance (AUPRC, 0.773 0.080) and sensitivity (0.655 0.096), though with lower specificity (0.920 0.035). Stroke severity (NIH Stroke Scale score) was the dominant predictor across models. Among biomarkers, brain-deriv …
The MLP achieved the highest precision-recall performance (AUPRC, 0.773 0.080) and sensitivity (0.655 0.096), though with lower specific …
Ser423-phosphorylated MECP2 (MECP2-pS423) accumulates in human brain, cerebrospinal fluid and serum in sporadic Alzheimer's disease.
Liu QR, Zhu M, Perez K, Yao Q, Horowitz MS, Chen Q, Fantoni G, An Y, Resnick SM, Sedlock A, Maric D, Serrano GE, Egan JM, Ramsden CE. Liu QR, et al. Acta Neuropathol. 2026 Apr 15;151(1):38. doi: 10.1007/s00401-026-03008-3. Acta Neuropathol. 2026. PMID: 41986496
It is currently unknown whether phosphorylation at the corresponding site of human MECP2-pS423 plays a role in AD. We developed an MECP2-pS423-specific antibody, and a quantitative selective reaction monitoring (SRM) assay based on LC-MS/MS analysis, and we used immunohist …
It is currently unknown whether phosphorylation at the corresponding site of human MECP2-pS423 plays a role in AD. We developed an ME …
Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia.
Yang BZ, He L, Liu TQ, Ma S, Wu YF, Wen L, Emu B. Yang BZ, et al. Neuropsychopharmacology. 2026 Apr 15. doi: 10.1038/s41386-026-02407-0. Online ahead of print. Neuropsychopharmacology. 2026. PMID: 41986467
To investigate their causal roles and potential confounding effects, we applied genetically informed Mendelian randomization (MR) using genome-wide association study (GWAS) data from a large SCZ meta-analysis (52,017 cases and 75,889 controls), 72 GM genera, and 22 traits …
To investigate their causal roles and potential confounding effects, we applied genetically informed Mendelian randomization (MR) using g …
Minimally invasive bioelectronic implants.
Li P, Hibino N, Shi LL, Tian B. Li P, et al. Nat Mater. 2026 Apr 15. doi: 10.1038/s41563-026-02576-9. Online ahead of print. Nat Mater. 2026. PMID: 41986453 Review.
Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.
Su Y, Liu C, Lu X, Chuang HY, Li G, Shao S, Kong Y, Lee JW, Ng RH, Wong S, Robert L, Warden C, Liu V, Chen J, Wang Z, Qin G, Tang Y, Cheng H, Ng AHC, Chen D, Peng S, Xue M, Johnson D, Xu Y, Wang J, Wu X, Shmulevich I, Shi Q, Levine R, Ribas A, Baltimore D, Guo J, Heath JR, Wei W. Su Y, et al. Nat Commun. 2026 Apr 15;17(1):3228. doi: 10.1038/s41467-026-71349-4. Nat Commun. 2026. PMID: 41986344
We uncover a hysteretic transition trajectory in response to oncogene inhibition and subsequent release, driven by two tightly coupled transcriptional waves that orchestrate genome-scale chromatin reconfiguration. Modeling of these waves suggests NF-kappaB/RelA-driven chro …
We uncover a hysteretic transition trajectory in response to oncogene inhibition and subsequent release, driven by two tightly coupled trans …
A randomized feasibility pilot trial of a remotely delivered physical activity intervention for adults with epilepsy.
Alexander HB, O'Connell N, Munger Clary HM, Burgos-Aguilar C, Peters C, Brubaker PH, Fountain NB, Shaltout HA, Fanning J. Alexander HB, et al. Epilepsy Behav. 2026 Apr 14;180:111051. doi: 10.1016/j.yebeh.2026.111051. Online ahead of print. Epilepsy Behav. 2026. PMID: 41985206
The intervention group received a 12-week program led by a trained health coach aimed to progressively increase daily steps while the control group received biweekly telephone education on healthy living. ...
The intervention group received a 12-week program led by a trained health coach aimed to progressively increase daily steps while the …
LySeqST: A targeted sequencing assay for robust genomic classification of diffuse large B-cell lymphoma.
Hilton LK, Gillis S, Yahyaei-Moayyed F, Bridgers J, Alduaij W, Jiang A, Ben-Neriah S, Collinge B, Wong JCH, Boyle M, Meissner B, Slack GW, Farinha P, Craig JW, Gerrie AS, Villa D, Savage KJ, Sehn LH, Karsan A, Wright G, Staudt LM, Morin RD, Steidl C, Scott DW. Hilton LK, et al. Blood Adv. 2026 Apr 15:bloodadvances.2026020105. doi: 10.1182/bloodadvances.2026020105. Online ahead of print. Blood Adv. 2026. PMID: 41985007
Rhesus macaques with an OPA1 mutation demonstrate features of autosomal dominant optic atrophy.
Jaggers TN, Ripolles-Garcia A, Moshiri A, Story BD, Wang J, Chen R, Moore LG, Teixeira LBC, Shim J, Raposo AC, Casanova MI, Le SM, Park S, Young LJ, Kim S, Roszak KP, Ureno V, Karpinen PM, Echeverria N, Ardon M, Leonard BC, Knipe M, Bliss-Moreau E, Fortune B, Stout JT, Rogers J, Marsh-Armstrong N, Thomasy SM. Jaggers TN, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2509165123. doi: 10.1073/pnas.2509165123. Epub 2026 Apr 15. Proc Natl Acad Sci U S A. 2026. PMID: 41984835
The observed similar pattern of RGC loss and dysfunction coupled with phenotypic heterogeneity in our NHP model reflects the clinical variability observed in human ADOA patients indicating that therapeutic interventions in this foveate model will likely translate to the …
The observed similar pattern of RGC loss and dysfunction coupled with phenotypic heterogeneity in our NHP model reflects the clinical variab …
Rubisco kinetic acclimation at the holoenzyme level.
Askey B, Ceminsky M, Scott E, Wang Y, Oh ZG, Azinas S, Laganowsky A, Gunn LH. Askey B, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2519914123. doi: 10.1073/pnas.2519914123. Epub 2026 Apr 15. Proc Natl Acad Sci U S A. 2026. PMID: 41984832
Constrained evolutionary funnels shape viral immune escape.
Huot M, Wang D, Shakhnovich E, Monasson R, Cocco S. Huot M, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2536956123. doi: 10.1073/pnas.2536956123. Epub 2026 Apr 15. Proc Natl Acad Sci U S A. 2026. PMID: 41984829
Gene regulation in response to host sex and infection route in Brugia pahangi with new genome annotation.
Holt CI, Bromley RE, Sparklin BC, Mattick J, Foster JM, Michalski ML, Dunning Hotopp JC. Holt CI, et al. G3 (Bethesda). 2026 Apr 15:jkag073. doi: 10.1093/g3journal/jkag073. Online ahead of print. G3 (Bethesda). 2026. PMID: 41984800
The lack of impact of host sex on the transcriptome of worms isolated from IP-infected gerbils reinforces the use of male gerbils as the primary rearing host for these parasites. Genome annotation of B. pahangi is reported as it was required for this differential expressio …
The lack of impact of host sex on the transcriptome of worms isolated from IP-infected gerbils reinforces the use of male gerbils as the pri …
Epigenetics and chromatin structure regulate var2csa expression and the placental-binding phenotype in Plasmodium falciparum.
Lenz T, Sirel M, Hoppe H, Shafeeq S, Le Roch KG, Ribacke U. Lenz T, et al. Elife. 2026 Apr 15;13:RP93632. doi: 10.7554/eLife.93632. Elife. 2026. PMID: 41984626 Free PMC article.
Plasmodium falciparum is responsible for what appears to be a never-ending public health issue in the developing world. With repeated infections, a gradual semi-immunity to severe malaria can be acquired, but this is disrupted when women become pregnant as the parasite cyt …
Plasmodium falciparum is responsible for what appears to be a never-ending public health issue in the developing world. With repeated …
Longitudinal Analysis of Substance Use as a Predictor PrEP Use and Adherence Among Young Transgender Women and Nonbinary Individuals.
Zamantakis A, Queiroz AAFLN. Zamantakis A, et al. AIDS Behav. 2026 Apr 15. doi: 10.1007/s10461-025-04986-3. Online ahead of print. AIDS Behav. 2026. PMID: 41984388
Previous research on the influence of substance use on PrEP uptake and adherence among transgender women has either relied on cross-sectional analyses or on combined samples of cisgender men who have sex with men and a much smaller subsample of transgender women. ...These …
Previous research on the influence of substance use on PrEP uptake and adherence among transgender women has either relied on cross-s …
Radiation-induced remodeling of the T cell landscape in head and neck cancer.
Memon AA, Said I, Norenberg E, Frei A, Foeckler J, Sun F, Dwinell MB, Lochhead RB, Bruening J, Akakpo K, Massey B, Wong SJ, Hematti P, Kearl TJ, Awan MJ, Himburg HA, Zenga J. Memon AA, et al. Cancer Immunol Immunother. 2026 Apr 15;75(5):148. doi: 10.1007/s00262-026-04389-w. Cancer Immunol Immunother. 2026. PMID: 41984232 Review.
Urogenital Hiatus Closure System: A Framework for Understanding how Muscle, Motor Control, and Fascial Connections Interact in Normal and Failed Closure.
DeLancey JOL, Ashton-Miller JA, LaCross J, Schmidt P, Masteling M, Pipitone F, Hong CX, Chen L. DeLancey JOL, et al. Int Urogynecol J. 2026 Apr 15. doi: 10.1007/s00192-026-06641-4. Online ahead of print. Int Urogynecol J. 2026. PMID: 41984211
This systems-based approach can guide classification of failure patterns to inform biomechanical, anatomical, and therapeutic research....
This systems-based approach can guide classification of failure patterns to inform biomechanical, anatomical, and therapeutic research …
Gender equality and equity in intensive care: an international Delphi consensus study.
Myatra SN, Nasa P, Chanchalani GP, Zimmerman JL, Venkatesh B, Machado FR, Ostermann M, Leeies M, Coopersmith CM, Sorce LR, Weiss B, Kuberkar D, Abbenbroek B, Acharya SP, Akech S, Akinci SB, Al Duhailib Z, Berger-Estilita J, Branson RD, De Waele J, Derde LPG, Divatia MJ, Dzierba AL, Elhoufy AM, Fiest KM, Fillipescu D, Fox-Robichaud AE, Freires FJC, Fujii T, Galarza L, Gopalan DP, Hamzaoui O, Hidalgo JL, Jayasinghe AS, Kanoore Edul VS, Lubis AP, Matot I, Mehta S, Milic V, Monnet X, Morrow BM, Nadkarni VM, Needham DM, Osinaike BB, Patil VP, Pérez Cornejo MS, Perez-Fernandez J, Ray S, Robba C, Rodriguez-Vega GM, Rubulotta F, Seifelnasr O, Turnbull AE, Ugarte S, Vincent JL, Wendon J, Xie J, Zabaleta Polo YM, Burns KEA. Myatra SN, et al. Intensive Care Med. 2026 Apr 15. doi: 10.1007/s00134-026-08394-6. Online ahead of print. Intensive Care Med. 2026. PMID: 41984151 Review.
The discordant statements highlight areas for future research....
The discordant statements highlight areas for future research....
HDAC3 Regulates Transcriptional Networks Governing Decidualization.
Nguyen LTK, Tran DN, Nahar S, Kim TH, Jeong JW, Yoo JY. Nguyen LTK, et al. FASEB J. 2026 Apr 30;40(8):e71815. doi: 10.1096/fj.202600629R. FASEB J. 2026. PMID: 41984129 Free PMC article.
Our previous study demonstrated that loss of histone deacetylase 3 (HDAC3) impairs endometrial receptivity and decidualization, resulting in female infertility. However, the genome-wide transcriptomic alterations responsible for defective decidualization in loss of HDAC3 r …
Our previous study demonstrated that loss of histone deacetylase 3 (HDAC3) impairs endometrial receptivity and decidualization, resulting in …
Cellular and molecular regulation of fibrotic post-operative abdominal adhesions.
Mathewson AJ, Loszko AF, Ackerman JE, Wilson NA, Loiselle AE. Mathewson AJ, et al. Am J Physiol Cell Physiol. 2026 Apr 15. doi: 10.1152/ajpcell.00037.2026. Online ahead of print. Am J Physiol Cell Physiol. 2026. PMID: 41984042 Review.
Disruption of homeostatic wound healing pathways, perhaps through aberrant signals from immune cells or the disrupted matrix, causes fibroblasts to produce excess extracellular matrix (ECM), resulting in a tenacious, vascularized, and innervated tissue that poses an intractable r …
Disruption of homeostatic wound healing pathways, perhaps through aberrant signals from immune cells or the disrupted matrix, causes fibrobl …
Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Diabetes Mellitus.
Bu F, Wu R, Ostropolets A, Aminorroaya A, Chen HY, Chai Y, Dhingra LS, Falconer T, Hsu JC, Kim C, Lau WCY, Man KKC, Minty E, Morales DR, Nishimura A, Thangraraj P, Van Zandt M, Yin C, Khera R, Hripcsak G, Suchard MA. Bu F, et al. J Am Coll Cardiol. 2026 Apr 3:S0735-1097(26)05724-4. doi: 10.1016/j.jacc.2026.02.5123. Online ahead of print. J Am Coll Cardiol. 2026. PMID: 41984016
METHODS: We conducted a multinational, retrospective, new-user active-comparator cohort study using 10 U.S. and non-U.S. administrative claims and electronic health record databases. The study included 1,245,211 adults with T2DM receiving metfor …
METHODS: We conducted a multinational, retrospective, new-user active-comparator cohort study using 10 U.S. and non-U. …
Low-Level Airborne Particulate Matter and Risk of Hypertension Hospitalization in Older U.S. Adults.
Zhang Y, Zhang S, Wang Y, Spatz ES, Krumholz HM, Lu Y, Chen K. Zhang Y, et al. J Am Coll Cardiol. 2026 Apr 8:S0735-1097(26)05646-9. doi: 10.1016/j.jacc.2026.02.5112. Online ahead of print. J Am Coll Cardiol. 2026. PMID: 41984014
OBJECTIVES: In this study, we examined the association between long-term exposure to PM(2.5) concentrations below the U.S. Environmental Protection Agency annual standard of 9 mug/m(3) and the risk of hypertension-related hospitalization among Medicare beneficiaries …
OBJECTIVES: In this study, we examined the association between long-term exposure to PM(2.5) concentrations below the U.S. Env …
Thomas Graham Brown: Before his time.
Calabrese RL, Marder E. Calabrese RL, et al. Exp Physiol. 2026 Apr 15. doi: 10.1113/EP093413. Online ahead of print. Exp Physiol. 2026. PMID: 41983976 Review.
Parental responses to negative emotions predict neural not physiological regulation in children: Evidence from frontal alpha asymmetry and respiratory sinus arrhythmia.
Hong Y, Quiñones-Camacho LE, Bell MA. Hong Y, et al. Child Dev. 2026 Apr 15:aacag060. doi: 10.1093/chidev/aacag060. Online ahead of print. Child Dev. 2026. PMID: 41983740
Effective emotion regulation (ER) supports children's socioemotional health, yet little is known about parental influences on biological systems underlying ER. ...Children's ability to manage strong emotions supports social and academic success in childhood. Parents …
Effective emotion regulation (ER) supports children's socioemotional health, yet little is known about parental influences on biologi …
Evaluating FABP5 as a Therapeutic Target for Pain Management.
Warren W, Osborn M, Kaczocha M, Yates A, O'Sullivan S. Warren W, et al. Eur J Pain. 2026 Apr;30(4):e70267. doi: 10.1002/ejp.70267. Eur J Pain. 2026. PMID: 41983707 Review.
CONCLUSIONS: Whilst preclinical data support the potential of FABP5 inhibitors as novel analgesics, further research into sex differences and chronic dosing in visceral and inflammatory pain models is warranted. ...
CONCLUSIONS: Whilst preclinical data support the potential of FABP5 inhibitors as novel analgesics, further research into sex differe …
Reply to Chen and Yeh.
Enders JD, Stucky CL. Enders JD, et al. Pain. 2026 May 1;167(5):1238-1239. doi: 10.1097/j.pain.0000000000003887. Epub 2025 Dec 8. Pain. 2026. PMID: 41983672 No abstract available.
TAD boundaries and gene activity are uncoupled.
Almansour F, Fursova NA, Keikhosravi A, Reed KSM, Larson DR, Pegoraro G, Misteli T. Almansour F, et al. Elife. 2026 Apr 15;15:RP110197. doi: 10.7554/eLife.110197. Elife. 2026. PMID: 41983545 Free PMC article.
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. ...
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute …
Patient views on blood-based biomarker tests for Alzheimer's disease in primary care.
Russell A, Vogeley A, Lovett R, O'Conor R, Batio S, Hurtado J, Bonham M, Benavente JY, Brickman AM, Williamson JD, Udeh-Momoh C, Mielke MM, Wolf M. Russell A, et al. Alzheimers Dement. 2026 Apr;22(4):e71247. doi: 10.1002/alz.71247. Alzheimers Dement. 2026. PMID: 41983466
Participants commonly expected they would experience emotional distress and motivation to improve brain health after a positive test. DISCUSSION: Primary care patients educated about biomarker testing were generally willing to undergo testing and support its use. ...
Participants commonly expected they would experience emotional distress and motivation to improve brain health after a positive test. …
Multi-Tiered µDicer Enables Protein-Preserving Microdissection at 10 µm Resolution.
Arif A, Kumar R, Kwon Y, Rodriguez R, Cordts SC, Koppaka S, Zhu Y, Paša-Tolić L, Tang SKY. Arif A, et al. Small. 2026 Apr 15:e14816. doi: 10.1002/smll.202514816. Online ahead of print. Small. 2026. PMID: 41983365
For benchmarking, proteomic analysis is performed on ethanol-fixed human squamous cell carcinoma microtissues generated by Dicers and by LCM. Under identical Nanodroplet Processing in One pot for Trace Samples (nanoPOTS) and liquid chromatography-mass spectrometry (LC-MS) …
For benchmarking, proteomic analysis is performed on ethanol-fixed human squamous cell carcinoma microtissues generated by Dicers an …
"It's Not Deterministic and It Will Never Be Deterministic": A Qualitative Study on Stakeholder Perspectives of Polygenic Risk Score Testing for Post-Traumatic Stress Disorder.
Fox BM. Fox BM. Am J Med Genet B Neuropsychiatr Genet. 2026 Apr 15. doi: 10.1002/ajmg.b.70018. Online ahead of print. Am J Med Genet B Neuropsychiatr Genet. 2026. PMID: 41983294
Through semi-structured interviews, I developed three themes that each convey a unique aspect of how research participants conceptualize some potential avenues for pre-empting and living with PTSD, should PRS become widely available: (1) Controlling what you can; (2) The c …
Through semi-structured interviews, I developed three themes that each convey a unique aspect of how research participants conceptual …
A Single Dose Study of Pembrolizumab in People With HIV Infection Who are Immunologic Nonresponders.
Kuruppu J, Purdy JB, Pauls C, Rogan DC, Blazkova J, Kardava L, Sewack AB, Proschan MA, Migueles SA, Connors M, Webber JD, Meeks T, Przygonska PA, Adelsberger JW, Higgins J, Rupert A, Moir SL, Chun TW, Lane HC, Kovacs JA. Kuruppu J, et al. Open Forum Infect Dis. 2026 Apr 3;13(4):ofag203. doi: 10.1093/ofid/ofag203. eCollection 2026 Apr. Open Forum Infect Dis. 2026. PMID: 41983147 Free PMC article. Clinical Trial.
Lightweight hybrid foundation model for lung cancer prognosis based on low-dose chest X-ray images.
Hayeso HH, Lonseko ZM, Alotaibi FMG, Gan T, Shi P, Dong S, Rao N. Hayeso HH, et al. Transl Lung Cancer Res. 2026 Mar 23;15(3):47. doi: 10.21037/tlcr-2025-aw-1299. Epub 2026 Feb 26. Transl Lung Cancer Res. 2026. PMID: 41982697 Free PMC article.
The model was trained and validated on the JSRT and PadChest datasets, with external validation on multicenter datasets including the NIH CXR. Performance was evaluated using the concordance index (C-index), area under the receiver operating characteristic curve (AUROC), a …
The model was trained and validated on the JSRT and PadChest datasets, with external validation on multicenter datasets including the NIH …
Blogs as data: using XQuery for content evaluation.
Wachter E, Mullen EA. Wachter E, et al. J Med Libr Assoc. 2026 Apr 1;114(2):169-170. doi: 10.5195/jmla.2026.2338. Epub 2026 Apr 13. J Med Libr Assoc. 2026. PMID: 41982435 Free PMC article.
Circulating Now, the history of medicine blog for the National Library of Medicine (NLM), highlights blog posts written by community contributors. ...
Circulating Now, the history of medicine blog for the National Library of Medicine (NLM), highlights blog posts written by community …
A generalist institutional data repository offering both open and restricted access to support NIH data sharing compliance.
Kim S, Jian X, Vana ML. Kim S, et al. J Med Libr Assoc. 2026 Apr 1;114(2):176-177. doi: 10.5195/jmla.2026.2339. Epub 2026 Apr 13. J Med Libr Assoc. 2026. PMID: 41982430 Free PMC article.
In response to the 2023 NIH Data Management and Sharing (DMS) Policy, Washington University School of Medicine in St. ...Draft Digital Object Identifiers (DOIs) can be issued once access type is determined, with final DOI publication following curation and QC. Restricted d …
In response to the 2023 NIH Data Management and Sharing (DMS) Policy, Washington University School of Medicine in St. ...Draft Digita …
Association of the Change in USMLE Step 1 Scoring With Research Output Among Applicants to Anesthesiology Residency Programs: A Retrospective Observational Study.
Bhardwaj A, Bajaj P, Rifai K, Patel A, Bhatt A, Abolhassani A, McClain J, Ahmed A, Bailey C, Arthur M. Bhardwaj A, et al. J Educ Perioper Med. 2026 Apr 13;28(1):E760. doi: 10.46374/VolXXVIII_Issue1_Bhardwaj. eCollection 2026 Jan-Mar. J Educ Perioper Med. 2026. PMID: 41982265 Free PMC article.
BACKGROUND: As anesthesiology residency becomes increasingly competitive, the transition of US Medical Licensing Examination (USMLE) Step 1 to pass/fail scoring has raised questions about the evolving role of research in applicant selection. Whereas national data su …
BACKGROUND: As anesthesiology residency becomes increasingly competitive, the transition of US Medical Licensing Examination (USMLE) Step 1 …
The guiding role of gastric filling ultrasonography in the diagnosis of stromal tumors and schwannomas-a retrospective study.
Wang Y, Qi X, Deng L, Liu C, Liu S. Wang Y, et al. Front Oncol. 2026 Mar 30;16:1680846. doi: 10.3389/fonc.2026.1680846. eCollection 2026. Front Oncol. 2026. PMID: 41982245 Free PMC article.
OBJECTIVE: To differentiate the ultrasonographic characteristics of gastric stromal tumors (GSTs) and gastric schwannomas (GSs) identified via gastric filling ultrasonography and investigate the relationship between National Institutes of Health (NIH) …
OBJECTIVE: To differentiate the ultrasonographic characteristics of gastric stromal tumors (GSTs) and gastric schwannomas (GSs) identified v …
Synthetic Mechanogenetic Gene Circuit Response in Human Induced Pluripotent Stem Cell-Derived Chondrocytes Is Altered by Matrix Stiffness.
Kim YS, Kim A, Steward N, Strandberg K, Guilak F. Kim YS, et al. J Biomed Mater Res A. 2026 Apr;114(4):e70077. doi: 10.1002/jbm.a.70077. J Biomed Mater Res A. 2026. PMID: 41981992
We modeled the effects of varying degrees of degradation on cartilage mechanical properties using 3D agarose hydrogel constructs with varying concentrations, which were used to encapsulate human induced pluripotent stem cell (iPSC)-derived chondrocytes. Hydrogel stiffness …
We modeled the effects of varying degrees of degradation on cartilage mechanical properties using 3D agarose hydrogel constructs with varyin …
Immediate Loading on Tapered Versus Straight Multiple Implants: A 3-Year Follow-Up of a Randomized Clinical Trial.
Song YW, Park SH, Strauss FJ, Yoo SJ, Park JY, Cha JK, Jung UW. Song YW, et al. Clin Implant Dent Relat Res. 2026 Apr;28(2):e70147. doi: 10.1111/cid.70147. Clin Implant Dent Relat Res. 2026. PMID: 41981962 Clinical Trial.
TRAIL REGISTRATION: KCT0002489; https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&focus=reset_12&search_page=L&pageSize=10&page=undefined&seq=19032&status=5&seq_group=8332....
TRAIL REGISTRATION: KCT0002489; https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&focus=reset_12&search_page=L …
Sensory Impairment and Risk of Elder Mistreatment in Community-Dwelling Older Adults.
Rosenberg MW, Li E, Xue WL, Eckstrom E, Howe M, Smith AK, Kotwal AA. Rosenberg MW, et al. J Am Geriatr Soc. 2026 Apr 14. doi: 10.1111/jgs.70454. Online ahead of print. J Am Geriatr Soc. 2026. PMID: 41981819
METHODS: We used nationally-representative, cross-sectional data from the National Social Life, Health, and Aging Project, including interview rounds with available assessments of recent elder mistreatment (Round 1 (R1): 2005-06 and Round 4 (R4): 2021-23). .. …
METHODS: We used nationally-representative, cross-sectional data from the National Social Life, Health, and Aging Proje …
A White Paper on Advancing Long-Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation.
Archary M, Bies R, Boateng O, Daley R, Gashema P, Karina M, Njuguna E, Nachman S, Nkrumah N, Odula C, Owen A, Weld ED, Venkatasubramanian P, Olagunju A; Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health. Archary M, et al. Clin Pharmacol Ther. 2026 Apr 14. doi: 10.1002/cpt.70288. Online ahead of print. Clin Pharmacol Ther. 2026. PMID: 41981739 Review.
Attendees included stakeholders drawn from clinical practice, patient advocacy groups, academia, pharmaceutical industry, regulatory agencies, product development partners, and public health organizations. Four focus groups-centered on maternal health, pediatric …
Attendees included stakeholders drawn from clinical practice, patient advocacy groups, academia, pharmaceutical industry, regulatory agencie …
Traumatic brain injury and risk of early-onset dementia: A population-based cohort study.
Saravanan A, Giorgio K, Lakomski N, Schneider ALC, Olson-Bullis BA, Sabayan B, Pankow JS, de Vries PS, Yaffe K, Beiser A, Dehghan A, Peterson EA, Zmora R, Stephen JJ, Scholtens D, Mansolf M, Launer LJ, MacLehose RF, Lutsey PL, Allen NB, Sedaghat S. Saravanan A, et al. Alzheimers Dement. 2026 Apr;22(4):e71387. doi: 10.1002/alz.71387. Alzheimers Dement. 2026. PMID: 41981712 Free PMC article.
Lineage-specific evolution, structural diversity, and activity of R2 retrotransposons in animals.
Hassan NT, Van Treeck B, Rodríguez-Vargas A, Sheppard AE, Collins K, Adelson DL. Hassan NT, et al. Genome Biol. 2026 Apr 14. doi: 10.1186/s13059-026-04073-3. Online ahead of print. Genome Biol. 2026. PMID: 41981679 Free article.
BACKGROUND: Retrotransposons play outsized roles in the evolution of gene regulation, genome function, and disease pathogenesis, and more recently they have sparked interest as instruments for new gene therapy approaches. ...We discover diverse R2 domain architectures and …
BACKGROUND: Retrotransposons play outsized roles in the evolution of gene regulation, genome function, and disease pathogenesis, and …
A mixed methods evaluation of mechanisms for facilitation in pediatric primary care.
Boggs JM, Williams N, Waller CR, Pandey M, Johnson C, Ahmedani BK, Pappas C, Bedjeti K, Maye M, Wolk CB, Buttenheim AM, Linn KA, Wright L, Daley MF, Small DS, Beidas RS. Boggs JM, et al. Implement Sci Commun. 2026 Apr 14. doi: 10.1186/s43058-026-00941-y. Online ahead of print. Implement Sci Commun. 2026. PMID: 41981665 Free article.
Second, qualitative interviews guided by the updated Consolidated Framework for Implementation Research, and analyzed using deductive and inductive approaches, were conducted with pediatric clinicians, clinic change agents, and health system leaders to ascertain oth …
Second, qualitative interviews guided by the updated Consolidated Framework for Implementation Research, and analyzed using deductive …
Amyloid-β PET scans, economic strain and financial decision-making among persons with cognitive impairment and care partners: a mixed-methods analysis of the CARE-IDEAS study.
Van Houtven CH, Ford CB, Couch E, Shepherd-Banigan M, Zhang W, Bélanger E, Plassman BL, Burke JR, Sorenson C, DePasquale N, O'Brien E, Jutkowitz E, Wetle T, Smith VA. Van Houtven CH, et al. Alzheimers Res Ther. 2026 Apr 14. doi: 10.1186/s13195-026-02010-x. Online ahead of print. Alzheimers Res Ther. 2026. PMID: 41981607 Free article. No abstract available.
Characterizing Oral Microbiome and Periodontal Disease in Oral HPV-Positive (COMP-HPV) individuals with HIV: an observational longitudinal study protocol.
Bangera SR, Subbiah R, Govindaraj S, Ibegbu C, Reznik D, Read TD, Hartman TJ, Paul S, Torres-Patarroyo N, Lymon KJ, Ciers-Davis NA, Nguyen ML, Bruner DW, Flowers L, Velu V, Xiao C. Bangera SR, et al. BMC Oral Health. 2026 Apr 14. doi: 10.1186/s12903-026-08193-x. Online ahead of print. BMC Oral Health. 2026. PMID: 41981555 Free article. No abstract available.
Maternal and fetal determinants on kidney size in early childhood: insights from a New York City cohort.
Ling R, Seok E, Encarnacion S, Kapoor V, Liu M, Afanasyeva Y, Lala S, Vokshi FH, Liu J, Malaga-Dieguez L, Trasande L. Ling R, et al. BMC Nephrol. 2026 Apr 14. doi: 10.1186/s12882-026-04913-1. Online ahead of print. BMC Nephrol. 2026. PMID: 41981395 Free article.
METHODS: We analyzed data from 892 mother-child pairs enrolled in the New York University Children's Health and Environment Study (CHES). Renal sonographic measurements were taken from one to six years of age. ...
METHODS: We analyzed data from 892 mother-child pairs enrolled in the New York University Children's Health and Environment St …
Neural mechanisms of negative emotionality and cognitive control: The role of frontal midline theta.
Teich CD, Rawls E, Stevens KL, Kang SSS, Davenport ND, Sponheim SR, Polusny MA, Marquardt CA. Teich CD, et al. Cogn Affect Behav Neurosci. 2026 Apr 14. doi: 10.3758/s13415-026-01434-0. Online ahead of print. Cogn Affect Behav Neurosci. 2026. PMID: 41981381
Using a Go/No-Go task, we examined how theta and alpha frequency activity (3-8 and 10-20 Hz, respectively) within electroencephalography (EEG) recorded over middle frontal regions of the scalp (i.e., frontal midline theta [FMT]) may be sensitive to the effects of personality trai …
Using a Go/No-Go task, we examined how theta and alpha frequency activity (3-8 and 10-20 Hz, respectively) within electroencephalography (EE …
Comparing Methods for Attributing Hospital Quality Metrics to Individual Physicians: Impact on Performance Assessment and Outlier Identification.
Carmichael HL, Woller SC, Brown SM, Asch SM, Srivastava R, Pirozzi M, Peltan ID. Carmichael HL, et al. J Gen Intern Med. 2026 Apr 14. doi: 10.1007/s11606-026-10391-w. Online ahead of print. J Gen Intern Med. 2026. PMID: 41981374
DESIGN: Retrospective comparative analysis of hospitalist encounters in a multi-hospital health system from January 2020 to September 2024. PARTICIPANTS: 95,112 eligible hospital encounters overseen by 135 physician/hospital pairs across four Utah hospitals. ...
DESIGN: Retrospective comparative analysis of hospitalist encounters in a multi-hospital health system from January 2020 to September …
The Canadian multi-ethnic research on aging (CAMERA) study: Design, participant characteristics, and preliminary findings.
Marawi T, Rai H, Kumar R, Vandeloo KL, Yep R, Alexander MW, Boshmaf SZ, Chen SM, Gopinath G, Malhotra S, Zhang A, Nyman AJ, Perri LX, Sit V, Splinter TFL, Munoz DP, Swardfager W, Ryan JD, Black SE, Goubran M, Rabin JS. Marawi T, et al. Alzheimers Dement. 2026 Apr;22(4):e71344. doi: 10.1002/alz.71344. Alzheimers Dement. 2026. PMID: 41981367 Free PMC article.
INTRODUCTION: South Asian and Chinese individuals are the largest and fastest-growing ethnoracial groups in Canada, yet they remain underrepresented in dementia research. To address this gap, we established the CAnadian Multi-Ethnic Research on Aging (CAMERA) study. …
INTRODUCTION: South Asian and Chinese individuals are the largest and fastest-growing ethnoracial groups in Canada, yet they remain underrep …
A mixed-methods approach for understanding cancer center catchment area needs: An example of rural cancer disparities, needs, and resiliencies.
Evett S, Kahl A, Schmidt ME, Wells Sittig K, Meyer M, Charlton M, Askelson NM, Nash SH. Evett S, et al. Cancer Causes Control. 2026 Apr 15;37(5):82. doi: 10.1007/s10552-026-02166-9. Cancer Causes Control. 2026. PMID: 41981345 Free PMC article.
PURPOSE: National Cancer Institute-designated Cancer Center Community Outreach and Engagement (COE) teams are expected to collect data to describe their catchment area's cancer burden. University of Iowa Health Care Holden Comprehensive Cancer Center employed …
PURPOSE: National Cancer Institute-designated Cancer Center Community Outreach and Engagement (COE) teams are expected to coll …
In vivo base editing rescues liver pathophysiology and peroxisome dysfunction in a mouse model of Zellweger spectrum disorder.
Gao XD, Presa M, Duby JE, Ryan J, Piec PA, Hsu A, Banskota S, Jiang AY, Chen L, Newby GA, Di Pietro E, Levy JM, Steele BH, Lecordier S, Qin F, Moser AB, Xie J, Gao G, Braverman NE, Zuberi AR, Hacia JG, Lutz CM, Liu DR. Gao XD, et al. Nat Biomed Eng. 2026 Apr 14. doi: 10.1038/s41551-026-01651-5. Online ahead of print. Nat Biomed Eng. 2026. PMID: 41981313
The PEX1-p.G843D (c.2528G>A) allele, present in approximately 30% of individuals with ZSD, frequently results in chronic liver disease that can progress to cirrhosis, hepatocellular carcinoma and degraded neurological health. Here we report the development and applicati …
The PEX1-p.G843D (c.2528G>A) allele, present in approximately 30% of individuals with ZSD, frequently results in chronic liver disease th …
Longitudinal associations of cardiorespiratory fitness and physical activity with changes in cognitive function in breast cancer patients undergoing chemotherapy: a prospective matched-control study.
Xiao H, Warner E, Ryan J, Sabiston C, Ghazinour G, O'Rourke S, Moore D, Welsh T, Trinh L. Xiao H, et al. Cancer Causes Control. 2026 Apr 15;37(5):83. doi: 10.1007/s10552-026-02165-w. Cancer Causes Control. 2026. PMID: 41981302
Cognitive function was assessed using the NIH Remote Cognition Toolbox (episodic memory, working memory, language/reading, verbal learning). ...
Cognitive function was assessed using the NIH Remote Cognition Toolbox (episodic memory, working memory, language/reading, verbal lea …
The R-CITY Youth Violence Preventive Intervention: Primary Outcomes from a School Cluster Randomized Controlled Trial.
Bottiani JH, Franco MP, Francis MK, Somerville K, Kaihoi CA, Pas ET, Bradshaw CP. Bottiani JH, et al. Prev Sci. 2026 Apr 15. doi: 10.1007/s11121-026-01907-1. Online ahead of print. Prev Sci. 2026. PMID: 41981234
To address this gap, researchers and educators partnered to develop R-CITY (Reducing Racism and Violence through Collaborative Intervention with Teachers and Youth; Bottiani et al., School Mental Health, 16(3), 632-648, 2024). A school-level randomized controlled trial was …
To address this gap, researchers and educators partnered to develop R-CITY (Reducing Racism and Violence through Collaborative Intervention …
Anti-amyloid antibody equilibrium binding to Abeta aggregates from human Alzheimer's disease brain.
Bjørnholm KD, Butler PM, Francis AE, Varma C, Spooner ET, Grenon MB, Xu YR, Tao Y, Meunier AL, Anderson AK, Hennessey EL, Miller MB, Selkoe DJ, Lemere CA, Stern AM. Bjørnholm KD, et al. Alzheimers Dement. 2026 Apr;22(4):e71350. doi: 10.1002/alz.71350. Alzheimers Dement. 2026. PMID: 41981185 Free PMC article.
INTRODUCTION: Lecanemab binds "protofibrils," which are poorly characterized in human brain. It is unknown why lecanemab caused fewer amyloid-related imaging abnormalities (ARIAs) than other antibodies in trials. ...
INTRODUCTION: Lecanemab binds "protofibrils," which are poorly characterized in human brain. It is unknown why lecanemab caused fewer …
Industrial point source emissions and incident breast and lung cancers: two case-control studies.
Boyle J, Nana-Sinkam P, McGuire KP, Fuemmeler BF. Boyle J, et al. Cancer Causes Control. 2026 Apr 15;37(5):81. doi: 10.1007/s10552-026-02168-7. Cancer Causes Control. 2026. PMID: 41981156 Free PMC article.
PURPOSE: Better understanding of the environment's role in breast cancer (BC) and lung cancer (LC) incidence is crucial for population health. Growing evidence suggests environmental factors may be relevant for these cancers. ...CONCLUSION: We observed relationships betwee …
PURPOSE: Better understanding of the environment's role in breast cancer (BC) and lung cancer (LC) incidence is crucial for population he …
Hi-C calibration by chemically induced chromosomal interactions.
Li Y, Fischer CWA, Zou F, Du M, Bai L. Li Y, et al. EMBO Rep. 2026 Apr 14. doi: 10.1038/s44319-026-00772-x. Online ahead of print. EMBO Rep. 2026. PMID: 41981084 Free article.
The genome-wide chromosome conformation capture method, Hi-C, has greatly advanced our understanding of genome organization. ...
The genome-wide chromosome conformation capture method, Hi-C, has greatly advanced our understanding of genome organization. . …
Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative.
Ferrara D, Pires M, Gutschmayer S, Yu J, Abdelhafez YG, Abenavoli E, Badawi RD, Chaudhari AJ, Chen MS Jr, Cherry SR, Frille A, Geist BK, Gruenert S, Hacker M, Hesse S, Kerkhoff T, Linder P, Pappisch J, Pusitz S, Raslan OA, Rausch I, Raychaudhuri SP, Sabri O, Schmidt FP, Sciagrà R, Spencer BA, Wang G, Wirtz H, Beyer T, Shiyam Sundar LK. Ferrara D, et al. Sci Data. 2026 Apr 14. doi: 10.1038/s41597-026-07218-y. Online ahead of print. Sci Data. 2026. PMID: 41980990 Free article.
Early life exposure to N-nitrosamine drives genotoxicity, mutagenesis, and tumorigenesis in DNA repair-deficient mice.
Volk LB, Norales M, Karjane C, Corrigan JJ, Alcaraz AJ, Pribyl LJ, Bugher NA, Blawas M, Dulski I, Arunachalam E, Gubina N, Michelsen E, Pichappan K, Yakimchuk N, Swanson M, Ma D, Levine SS, Plata DL, Croy RG, Samson LD, Essigmann JM, Yauk CL, Carrasco SE, Engelward BP. Volk LB, et al. Nat Commun. 2026 Apr 14. doi: 10.1038/s41467-026-71753-w. Online ahead of print. Nat Commun. 2026. PMID: 41980981 Free article.
N-Nitrosodimethylamine (NDMA) is a probable human carcinogen found in contaminated pharmaceuticals and drinking water, yet the impact of age on NDMA susceptibility remains poorly understood. ...
N-Nitrosodimethylamine (NDMA) is a probable human carcinogen found in contaminated pharmaceuticals and drinking water, yet the impact …
SpiR is a gut microbial enzyme that drives cholesterol conversion.
Arp G, Levy S, Jiang AK, Dufault-Thompson K, Zhong A, Grant M, Li Y, Jiang X, Hall B. Arp G, et al. Nat Commun. 2026 Apr 14;17(1):3495. doi: 10.1038/s41467-026-70820-6. Nat Commun. 2026. PMID: 41980965 Free PMC article.
We analyze a multi-omic dataset from three human cohorts and find that spiR homologs were strongly enriched in individuals exhibiting cholesterol conversion. ...
We analyze a multi-omic dataset from three human cohorts and find that spiR homologs were strongly enriched in individuals exhibiting …
Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults.
Yang HS, Anzai JAU, Yau WW, Healy BC, Román Viera AM, Maa C, Kirn D, Properzi MJ, Bellier JP, Schultz AP, Farrell ME, Jacobs HIL, Buckley RF, Papp KV, Marshall GA, Amariglio RE, Rentz DM, Liu L, Selkoe DJ, Verghese PB, Braunstein JB, Johnson KA, Sperling RA, Chhatwal JP. Yang HS, et al. Nat Commun. 2026 Apr 14;17(1):3188. doi: 10.1038/s41467-026-71269-3. Nat Commun. 2026. PMID: 41980948 Free PMC article.
Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids.
Osaki T, Delepine C, Osako Y, Kranz D, Levin A, Nelson C, Fagiolini M, Sur M. Osaki T, et al. Nat Commun. 2026 Apr 14. doi: 10.1038/s41467-026-71458-0. Online ahead of print. Nat Commun. 2026. PMID: 41980938 Free article.
Human cerebral organoids derived from induced pluripotent stem cells can recapture early developmental processes and reveal changes involving neurodevelopmental disorders. ...
Human cerebral organoids derived from induced pluripotent stem cells can recapture early developmental processes and reveal changes i …
Potent acridone antimalarial against all three life stages of Plasmodium.
Kancharla P, Dodean RA, Li Y, Zhang X, Kelly S, Charlton J, Binauhan AJ, Navarrete K, Garcia L, Mu J, Lu J, Caridha D, Madejczyk MS, Jin X, Dennis WE, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Chin GC, Chim-Ong A, Cui L, Qahash T, Shoue DA, Ferdig MT, Mockenhaupt FP, van Loon W, Ndoli JM, Kudyba H, Vega-Rodriguez J, Okitwi M, Kreutzfeld O, Docan C, Green C, Liu Y, Agulay A, Mirsalis J, Farrell SN, Probst AS, Nilsen A, Alday PH, Stone Doggett J, McFadden GI, Goodman CD, Catteruccia F, Rosenthal PJ, Riscoe MK, Cooper RA, Roth A, Kelly JX. Kancharla P, et al. Nat Commun. 2026 Apr 14. doi: 10.1038/s41467-026-71708-1. Online ahead of print. Nat Commun. 2026. PMID: 41980931 Free article.
Attributes of lead candidate T111 include potent in vitro activity against cultured parasites, ex vivo activity against clinical isolates, oral single-dose cure in an asexual blood-stage rodent model, inhibition of sexual blood-stage parasites, activity against relapsing parasite …
Attributes of lead candidate T111 include potent in vitro activity against cultured parasites, ex vivo activity against clinical isolates, o …
Safety and efficacy of ciltacabtagene autoleucel for relapsed/refractory multiple myeloma: a CIBMTR study.
Hansen DK, Dima D, Mian H, Devos J, Brazauskas R, Oloyede T, Afrough A, Ahmed N, Anderson L, Banerjee R, Berdeja JG, Bidikian A, Dhakal B, Dias A, Efebera Y, Faisal MS, Gowda L, Hashmi H, Mirza AS, Mohan M, Narra R, Rosko AE, Schroeder M, Nishihori T, Landau H, Usmani S, Pasquini MC, Akhtar OS, Sidana S, Patel KK. Hansen DK, et al. Blood Cancer J. 2026 Apr 14. doi: 10.1038/s41408-026-01496-w. Online ahead of print. Blood Cancer J. 2026. PMID: 41980929 Free article.
This study evaluates the safety and efficacy of cilta-cel in RRMM patients reported to the Center for International Blood and Marrow Transplant Research registry between March 2022 and December 2023 who met commercial release specifications. ...
This study evaluates the safety and efficacy of cilta-cel in RRMM patients reported to the Center for International Blood and Marrow Transpl …
Factors Associated With Adult Incarceration Among People With Opioid Use Disorder in New South Wales, Australia.
Macdonald C, Bharat C, Degenhardt L, Hickman M, Stone J, Sutherland R, Harrod M, Grebely J, Santo T Jr. Macdonald C, et al. Drug Alcohol Rev. 2026 May;45(4):e70153. doi: 10.1111/dar.70153. Drug Alcohol Rev. 2026. PMID: 41980714
DISCUSSION AND CONCLUSIONS: Injecting drug use, limited education, and childhood exposure to household substance use were associated with higher incarceration risk. There is a need to consider broader social and developmental factors in supporting individuals with OUD. Whi …
DISCUSSION AND CONCLUSIONS: Injecting drug use, limited education, and childhood exposure to household substance use were associated with hi …
The pituitary adenylate cyclase-activating polypeptide receptor and its splice variants: Unique roles in affective and motivated behavior.
Carpenter BA, Barson JR. Carpenter BA, et al. J Neuroendocrinol. 2026 Apr;38(4):e70186. doi: 10.1111/jne.70186. J Neuroendocrinol. 2026. PMID: 41980614 Review.
In the field of motivated behavior, however, there has been much more limited research on these variants. This review focuses on the PAC1 and its splice variants, to propose that they should be thoroughly characterized in the context of motivated behavior. ...Finally, the …
In the field of motivated behavior, however, there has been much more limited research on these variants. This review focuses on the …
PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy.
Lou H, Langan D, Syracuse N, Murphy EA, Kim S, Robinson E, Rossi NM, Xie Y, Tulsyan S, Joe T, Rodriguez I, Rao N, Oberley MR, Oelke M, Dean M. Lou H, et al. Neoplasia. 2026 Apr 13;76:101305. doi: 10.1016/j.neo.2026.101305. Online ahead of print. Neoplasia. 2026. PMID: 41980433 Free article.
Cervical cancer is largely driven by human papillomavirus (HPV) infection, yet clinically actionable molecular subtypes and effective targeted therapies remain limited. ...
Cervical cancer is largely driven by human papillomavirus (HPV) infection, yet clinically actionable molecular subtypes and effective …
The Association of Preoperative Cognitive Dysfunction to Common Intraoperative Electroencephalographic Parameters and Cerebral Hypoxia During Cardiac Surgery.
Behera A, Ramachandran RV, Hussain Z, Ihalainen RJ, Orui H, Peck J, Ananthakrishnan A, Mathur P, Muehlschlegel JD, Pittet JF, Bardia A, Schonberger RB, Kveraga K, Subramaniam B. Behera A, et al. Anesth Analg. 2026 May 1;142(5):964-974. doi: 10.1213/ANE.0000000000007724. Epub 2026 Apr 14. Anesth Analg. 2026. PMID: 41980267 Clinical Trial.
Outcomes After Minor Ischemic Stroke in Older Patients Treated With IV Thrombolysis vs Standard of Care in the TEMPO-2 Trial.
Ganesh A, Vatanpour S, Yu AYX, Barber P, Choi PMC, Field TS, Kate MP, Kleinig TJ, Shamy MCF, Chatterjee K, Molina CA, Campbell BCV, Appireddy R, Muir KW, Hill MD, Coutts SB; as the TEMPO-2 investigators. Ganesh A, et al. Neurology. 2026 May 12;106(9):e214925. doi: 10.1212/WNL.0000000000214925. Epub 2026 Apr 14. Neurology. 2026. PMID: 41980227 Clinical Trial.
Secondary outcomes included neurologic recovery according to the NIH Stroke Scale (NIHSS) at 5 days/discharge, vessel recanalization, Lawton Instrumental Activities of Daily Living Scale, EuroQol-5 Dimension (EQ-5D), and adverse events. ...
Secondary outcomes included neurologic recovery according to the NIH Stroke Scale (NIHSS) at 5 days/discharge, vessel recanalization, …
Distinct evolutionary patterns of endemic and emerging parvoviruses and the origin of a new pandemic virus.
López-Astacio RA, Wasik BR, Lee H, Voorhees IEH, Weichert WS, Adu OF, Goodman LB, Hafenstein SL, Truyen U, Parrish CR. López-Astacio RA, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2515274123. doi: 10.1073/pnas.2515274123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980105
Emergence of epidemic viruses in new hosts threatens both human and other animal populations, and often involves virus evolution to overcome barriers that normally prevent efficient infection and spread in that host. ...
Emergence of epidemic viruses in new hosts threatens both human and other animal populations, and often involves virus evolution to o …
A plasma-based DNA test for quantification of disease burden in acute myeloid leukemia patients undergoing bone marrow transplantation.
Wang Y, Xie J, Pasca S, Popoli M, Ptak J, Dobbyn L, Silliman N, Paul S, Jones RJ, Levis MJ, Curtis SD, Douville C, Shams C, Guo MZ, Mo S, Gocke CD, Malek SN, Bollard CM, Bettegowda C, Kinzler KW, Vogelstein B, Papadopoulos N, Gondek LP. Wang Y, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2537987123. doi: 10.1073/pnas.2537987123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980102
Evidence for strong purifying selection of human 47S ribosomal RNA genes.
Ma X, Chow F, Galbraith B, Sultanov D, Behar EK, Hochwagen A. Ma X, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2529741123. doi: 10.1073/pnas.2529741123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980101 Free PMC article.
The multicopy 47S ribosomal RNA (rRNA) genes are among the most highly expressed genes in the human genome, yet to-date essentially no disease-causing sequence variants have been identified. ...Here, we used an evolutionary approach to test whether mutations in the …
The multicopy 47S ribosomal RNA (rRNA) genes are among the most highly expressed genes in the human genome, yet to-date essent …
Trem2 exacerbates ischemic brain injury through Gpnmb in a photothrombotic stroke model.
Chen X, Li K, Liu S, Zhao J, Tiwari S, Zeng F, Zhao Y, Zhang P, Tang H, Zhao H, Kettenmann H, Xiang X, Zhu X. Chen X, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2523148123. doi: 10.1073/pnas.2523148123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980098
Ischemic stroke is a major public health challenge, with microglia-mediated neuroinflammation exerting both protective and detrimental effects on neuronal survival. ...Conversely, intracerebral administration of sTrem2 exacerbated neuronal loss, amplified inflammation, and …
Ischemic stroke is a major public health challenge, with microglia-mediated neuroinflammation exerting both protective and detrimenta …
Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors.
Brown DA, Koll KK, Brush E, Darner G, Curtis T Jr, Dvergsten T, Tran M, Milligan C, Wolfson DW, Gonzalez TJ, Jeffs S, Ehrhardt A, Bitolas R, Landau M, Reitz K, Salven DS, Slota-Burtt LA, Snee I, Singer-Freeman E, Bhatia S, Ou J, Asokan A, Currie JD, Poss KD. Brown DA, et al. Proc Natl Acad Sci U S A. 2026 Apr 28;123(17):e2532804123. doi: 10.1073/pnas.2532804123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980086
Updated consensus guidelines for the diagnosis and management of patients with hairy cell leukemia (HCL) and HCL-variant.
Zent CS, Tiacci E, Kreitman RJ, Tadmor T, Tallman MS, Wörmann BJ, Andritsos LA, Arons E, Banerji V, Barrientos JC, Bhat SA, Blachly JS, Broccoli A, Call TG, Dearden C, Demeter J, Dietrich S, El-Sharkawi D, Fagarasanu A, Falini B, Forconi F, Gerrie AS, Gladstone DE, Gozzetti A, Hampel PJ, Hermel DJ, Iyengar S, Johnston JB, Juliusson G, Kipps TJ, Lauria F, Lozanski G, Parikh SA, Park JH, Polliack A, Quest G, Rai KR, Ravandi F, Robak T Prof, Rogers KA, Saven A, Seymour JF, Tam CS, Troussard X, Zenz T, Zinzani PL, Grever MR. Zent CS, et al. Blood. 2026 Apr 14:blood.2025032757. doi: 10.1182/blood.2025032757. Online ahead of print. Blood. 2026. PMID: 41980020
Protein kinase C theta: evolution, regulation, and function.
Hodapp SJ, Manning G, Newton AC. Hodapp SJ, et al. Biochem J. 2026 May 6;483(5):603-620. doi: 10.1042/BCJ20250280. Biochem J. 2026. PMID: 41979916 Review.
However, unlike the extensively studied Ca2+-regulated conventional PKC isozymes, the mechanisms of PKCtheta and its roles in both health and disease remain relatively unexplored. In this review, we examine the evolution of PKCtheta, its domain structure and lifecycle, its …
However, unlike the extensively studied Ca2+-regulated conventional PKC isozymes, the mechanisms of PKCtheta and its roles in both health …
Prevalence and Predictors of Guideline Concordant Pediatric Obesity Care: A Narrative Review.
Orr CJ, Streetman AE, Carruyo IA, Beck AL, Queen K, Sanders T, Heerman WJ. Orr CJ, et al. Curr Obes Rep. 2026 Apr 14;15(1):34. doi: 10.1007/s13679-026-00712-9. Curr Obes Rep. 2026. PMID: 41979860 Free PMC article. Review.
For example, BMI measurement (KAS 1) is limited by missed well-child visits and insurance disparities, while comprehensive evaluation (KAS 2) faces challenges in mental health and social needs screening. Screening for comorbidities such as dyslipidemia, diabetes, an …
For example, BMI measurement (KAS 1) is limited by missed well-child visits and insurance disparities, while comprehensive evaluation (KAS 2 …
Overlaps in mammalian iron and manganese homeostasis: recent advances.
Prajapati M, Chiu L, Akpengbe J, Costeas C, Bartnikas TB. Prajapati M, et al. Biometals. 2026 Apr 14. doi: 10.1007/s10534-026-00808-8. Online ahead of print. Biometals. 2026. PMID: 41979805 Review.
Notably, while manganese is best known as a neurotoxicant, multiple recent studies have reported that variations in manganese levels correlate with a wide variety of parameters of health and disease. We then highlight deficiency in the manganese transport protein SLC30A10, …
Notably, while manganese is best known as a neurotoxicant, multiple recent studies have reported that variations in manganese levels correla …
Experiences of International and Puerto Rican Medical Graduates in the United States: A Cross-Sectional Survey.
Olazagasti C, Celi CV, Mahtani A, Kiel L, Velazquez AI, Horiguchi M, Sridhar A, Gonzalez M, Bernabe C, Abioye O, Dizman N, Florez N. Olazagasti C, et al. J Gen Intern Med. 2026 Apr 14. doi: 10.1007/s11606-026-10392-9. Online ahead of print. J Gen Intern Med. 2026. PMID: 41979730
We conducted a study to investigate reasons for migration, perceived barriers, discrimination, satisfaction, and factors influencing IMGs' and PRMGs' decisions to remain in the U.S. versus return to their home countries. METHODS: We conducted a cross-sectional, onli …
We conducted a study to investigate reasons for migration, perceived barriers, discrimination, satisfaction, and factors influencing IMGs' a …
Clonal Signatures of Telomere Biology Disorders.
Arcuri L, Groarke EM, Savage SA, Gutierrez-Rodrigues F. Arcuri L, et al. Curr Hematol Malig Rep. 2026 Apr 14;21(1):9. doi: 10.1007/s11899-026-00777-2. Curr Hematol Malig Rep. 2026. PMID: 41979702 Free PMC article. Review.
Salmonellosis in Poland in 2023.
Milczarek-Lisicka M, Czarkowski MP, Sadkowska-Todys M. Milczarek-Lisicka M, et al. Przegl Epidemiol. 2026 Mar 3;79(4):699-715. doi: 10.32394/pe/218175. Epub 2026 Feb 19. Przegl Epidemiol. 2026. PMID: 41979590 English, Polish.
Paratyphi) and remains a significant public health concern in Poland and worldwide. According to the CDC, the true burden of infection may be substantially underestimated. ...MATERIAL AND METHODS: The analysis was based on individual case data on salmonellosis, data on foo …
Paratyphi) and remains a significant public health concern in Poland and worldwide. According to the CDC, the true burden of infectio …
Pertussis in Poland in 2023.
Rumik A, Paradowska-Stankiewicz I. Rumik A, et al. Przegl Epidemiol. 2026 Mar 3;79(4):690-698. doi: 10.32394/pe/218544. Epub 2026 Mar 2. Przegl Epidemiol. 2026. PMID: 41979589 English, Polish.
MATERIAL AND METHODS: The assessment of the epidemiological situation of pertussis in Poland was made based on the results of the analysis of individual reports on pertussis cases registered at the National Institute of Public Health NIH - National …
MATERIAL AND METHODS: The assessment of the epidemiological situation of pertussis in Poland was made based on the results of the analysis o …
Lyme disease in Poland in 2023.
Zbrzeżniak JM, Paradowska-Stankiewicz I. Zbrzeżniak JM, et al. Przegl Epidemiol. 2026 Mar 3;79(4):682-689. doi: 10.32394/pe/216677. Epub 2026 Jan 15. Przegl Epidemiol. 2026. PMID: 41979588 English, Polish.
BACKGROUND: Lyme disease is a vector-borne disease transmitted by ticks of the Ixodes genus, caused by a heterogeneous group of Borrelia burgdorferi sensu lato. Human infection occurs through a tick bite and its feeding on the skin. Due to the diverse symptoms, diagnosing …
BACKGROUND: Lyme disease is a vector-borne disease transmitted by ticks of the Ixodes genus, caused by a heterogeneous group of Borrelia bur …
Syphilis in Poland in 2023.
Niedźwiedzka-Stadnik M, Zakrzewska K. Niedźwiedzka-Stadnik M, et al. Przegl Epidemiol. 2026 Mar 3;79(4):650-663. doi: 10.32394/pe/218342. Epub 2026 Feb 27. Przegl Epidemiol. 2026. PMID: 41979586 English, Polish.
Additionally aggregated data from MZ-56 reports on infectious diseases, infections and poisoning from 2017 to 2019 sent from Sanitary Inspections to NIPH NIH - NRI was used. Also, data about treatment patients in dermatology/venereology clinics in 2020-2023 reported on MZ- …
Additionally aggregated data from MZ-56 reports on infectious diseases, infections and poisoning from 2017 to 2019 sent from Sanitary Inspec …
HIV infections and AIDS in Poland in 2023.
Niedźwiedzka-Stadnik M, Nowakowska-Radziwonka E, Marzec-Bogusławska A. Niedźwiedzka-Stadnik M, et al. Przegl Epidemiol. 2026 Mar 3;79(4):633-649. doi: 10.32394/pe/217374. Epub 2026 Feb 3. Przegl Epidemiol. 2026. PMID: 41979585 English, Polish.
Frailty and Brain Myelin Across Adulthood: Multimodal MRI Insights From the BLSA.
Bouhrara M, Gong Z, Tanaka T, Ferrucci L. Bouhrara M, et al. Aging Cell. 2026 Apr;25(4):e70489. doi: 10.1111/acel.70489. Aging Cell. 2026. PMID: 41979393 Free PMC article.
Frailty is a state of reduced physiological resilience and increased vulnerability to adverse health outcomes, but its neurobiological mechanisms across the adult lifespan remain unclear. ...The study highlights myelin degradation as a candidate neural substrate of frailty …
Frailty is a state of reduced physiological resilience and increased vulnerability to adverse health outcomes, but its neurobiologica …
Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth.
Staples JW, Killam SR, Brown KE, Dalton R, Sather E, Chen Q, Loveland J, Schwanke C, Elias AF, Bigos KL, Woodahl EL. Staples JW, et al. Clin Pharmacol Ther. 2026 Apr 14. doi: 10.1002/cpt.70287. Online ahead of print. Clin Pharmacol Ther. 2026. PMID: 41979230
Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited. We conducted a genome-wide association study (GWAS) to investigate genetic predictors of risperidone response in pediatric patients (n = 161) who rece …
Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited. We conducted a …
Dependence of cell fate potential and cadherin switching on the coordinate within the primitive streak during differentiation of human pluripotent stem cells.
Zhu Y, Warmflash A. Zhu Y, et al. Development. 2026 Apr 1;153(7):dev204807. doi: 10.1242/dev.204807. Epub 2026 Apr 14. Development. 2026. PMID: 41979195
We made measurements of these processes during differentiation of human pluripotent stem cells to PS and downstream mesendoderm subtypes using established protocols and variants in which signaling through key pathways, including activin, BMP and Wnt, were modulated. ...
We made measurements of these processes during differentiation of human pluripotent stem cells to PS and downstream mesendoderm subty …
Renin-Angiotensin-Aldosterone System (RAAS) in Pig-to-Baboon Kidney Xenotransplantation-Relevance to Clinical Pig Kidney Xenotransplantation.
Terashita M, Kinoshita K, Satou R, Katsurada A, Lavalla GE, Maenaka A, Hidaka Y, Rosales IA, Ayares D, Kawai T, Navar LG, Cooper DKC. Terashita M, et al. Xenotransplantation. 2026 Mar-Apr;33(2):e70129. doi: 10.1111/xen.70129. Xenotransplantation. 2026. PMID: 41979182
BACKGROUND: Pig-to-human kidney xenotransplantation offers a potential solution to the organ shortage. However, the ability of the transplanted pig kidney to regulate blood pressure and fluid balance remains uncertain. ...However, the retention of a native kidney may help …
BACKGROUND: Pig-to-human kidney xenotransplantation offers a potential solution to the organ shortage. However, the ability of the tr …
Clinical Research Facilitators, Barriers, and Preferences of Parents of Children With Overweight and Obesity.
Lim CS, Patel DJ, Casady H, Sandridge S, Dodd CA, Malloch L, Annett RD. Lim CS, et al. J Dev Behav Pediatr. 2026 Apr 14. doi: 10.1097/DBP.0000000000001482. Online ahead of print. J Dev Behav Pediatr. 2026. PMID: 41979151
RESULTS: Parents endorsed more reasons and benefits for participation than mistrust, social pressure, and reasons against participation. Lower child body mass index was associated with higher perceptions of research participation benefits. Pandemic parental stress w …
RESULTS: Parents endorsed more reasons and benefits for participation than mistrust, social pressure, and reasons against participati …
Circadian rest/activity rhythms and change in MRI-derived brain volumes: Differences by age in a cognitively healthy sample.
Kaizi-Lutu MA, Callow DD, Rabinowitz JA, Lucey BP, An Y, Wu MN, Zipunnikov V, Bakker A, Davatzikos C, Simonsick EM, Walker KA, Ferrucci L, Resnick SM, Spira AP. Kaizi-Lutu MA, et al. Alzheimers Dement. 2026 Apr;22(4):e71190. doi: 10.1002/alz.71190. Alzheimers Dement. 2026. PMID: 41979141 Free PMC article.
DISCUSSION: Results link RARs with medial temporal lobe and global brain volumes and indicate that these associations may differ by age. Research is needed on the effects of RAR-focused interventions on brain health....
DISCUSSION: Results link RARs with medial temporal lobe and global brain volumes and indicate that these associations may differ by age. …
The policy exposome of dementia: Gaps, opportunities, and research agenda.
Kieny C, Marks G, Bourgeois M, Alladi S, Atshan S, Brayne C, Dow W, Glymour M, Knapp D, Livingston G, Mahmud M, Monnet N, Papanicolas I, Platt E, Rehkopf D, Sadana R, Wallace L, Walsh S, Wenner M, Avendano M. Kieny C, et al. Alzheimers Dement. 2026 Apr;22(4):e71362. doi: 10.1002/alz.71362. Alzheimers Dement. 2026. PMID: 41979011 Free PMC article.
We introduce the concept of the policy exposome and summarize findings from a structured expert consultation conducted by the Gateway Exposome Coordinating center (GECC) to identify priority policy research domains. We argue that systematic collection and harmonization of …
We introduce the concept of the policy exposome and summarize findings from a structured expert consultation conducted by the Gateway Exposo …
A harmonized framework for studying exceptional cognitive aging in Latin America.
Crivelli L, Fernandez R, Corvalán N, Sosa AL, Acosta D, Agnoletti G, Surace E, Acosta I, Caramelli P, Aguillón D, Martelli JL, Peñailillo LD, Custodio N, Charamelo A, Damian A, Llibre-Rodriguez JJ, Allegri R, Prina M, Rogalski E, Ibañez L, Llibre-Guerra JJ. Crivelli L, et al. Alzheimers Dement. 2026 Apr;22(4):e71373. doi: 10.1002/alz.71373. Alzheimers Dement. 2026. PMID: 41979010 Free PMC article.
DISCUSSION: LEARN-AD and LASAS represent the first Latin American infrastructure for studying cognitive resilience, resistance, and exceptional cognitive aging, which will generate unprecedented regional databases and grow into larger networks, providing foundations for resear …
DISCUSSION: LEARN-AD and LASAS represent the first Latin American infrastructure for studying cognitive resilience, resistance, and exceptio …
Benchmarking speech biomarkers of Alzheimer's against cognitive and neural measures.
Caro I, Pérez G, Bize JV, Ponferrada J, Ferrante FJ, Welford AS, Gauder L, Olavarría L, Henríquez F, Ramos T, Besnier C, Ferrer L, Gorno-Tempini ML, Slachevsky A, Ibañez A, García AM. Caro I, et al. Alzheimers Dement. 2026 Apr;22(4):e71365. doi: 10.1002/alz.71365. Alzheimers Dement. 2026. PMID: 41979006 Free PMC article.
Clinical Characteristics and Risk Factors for Syphilis Among People Living With Human Immunodeficiency Virus: A Nationwide Population-Based Cohort Study in Korea.
Kim S, Baek YJ, Lee E, Choi Y, Jeong O, Jung J, Kim TH, Choi JY. Kim S, et al. J Korean Med Sci. 2026 Apr 13;41(14):e115. doi: 10.3346/jkms.2026.41.e115. J Korean Med Sci. 2026. PMID: 41978926 Free PMC article.
BACKGROUND: The incidence of syphilis, a re-emerging infection linked to human immunodeficiency virus (HIV) through shared transmission routes, is increasing among people living with human immunodeficiency virus (PLH) in Korea. This study evaluate the prevalence, te …
BACKGROUND: The incidence of syphilis, a re-emerging infection linked to human immunodeficiency virus (HIV) through shared transmissi …
Efficacy and Tolerability of Viloxazine Extended-Release for Attention-Deficit/Hyperactivity Disorder in Adolescents and Adults: A Systematic Review With Qualitative Synthesis of All Studies and Meta-Analysis of Adolescent Data.
Chapman SR, Roberti C, Abouafech A, Mueller M. Chapman SR, et al. Cureus. 2026 Mar 13;18(3):e105176. doi: 10.7759/cureus.105176. eCollection 2026 Mar. Cureus. 2026. PMID: 41978610 Free PMC article. Review.
Adult outcomes were summarized descriptively due to limited data. Risk of bias was assessed using the National Institute of Health (NIH) Study Quality Assessment Tool. Safety outcomes were assessed qualitatively. ...The findings overall support viloxaz …
Adult outcomes were summarized descriptively due to limited data. Risk of bias was assessed using the National Institute of …
A multitransmitter, synaptic specification-segregated calyx-like synapse linking pontine pituitary adenylate cyclase-activating polypeptide neurons to forebrain-extended amygdala.
Zhang L, Hernández VS, Giraldo DM, Jiang SZ, León-Contreras JC, Ye R, Zhang S, Schäfer MKH, Barrio RA, Hernández-Pando R, Schoenherr S, Ferraguti F, Eiden LE. Zhang L, et al. PNAS Nexus. 2026 Mar 23;5(4):pgag083. doi: 10.1093/pnasnexus/pgag083. eCollection 2026 Apr. PNAS Nexus. 2026. PMID: 41978577 Free PMC article.
Clinical use and radiological yield of magnetic resonance fingerprinting in epilepsy.
Parfyonov M, Su TY, Choi JY, Blümcke I, Sakaie K, Morris S, Murakami H, Alexopoulos A, Najm I, Ma D, Jones SE, Wang ZI. Parfyonov M, et al. Epilepsia. 2026 Apr 14. doi: 10.1002/epi.70203. Online ahead of print. Epilepsia. 2026. PMID: 41978567
Although interest in MRF for epilepsy research has grown in recent years, systematic evaluation of its radiological and clinical value as a supplementary imaging modality is limited. ...
Although interest in MRF for epilepsy research has grown in recent years, systematic evaluation of its radiological and clinical valu …
Complex Substrates and Bedding for Environmental Enhancement and Research: Or, the Nature of Primates.
Sayers K, Allen J, Bellanca RU, Brown T, Coleman K, Janavaris M, Khuu JH, Lee GH, Perlman JE, Pomerantz O, Rosga M. Sayers K, et al. Am J Primatol. 2026 Apr;88(4):e70149. doi: 10.1002/ajp.70149. Am J Primatol. 2026. PMID: 41978564 Review.
A literature review, along with an informal survey and focus group involving individuals at the National Primate Research Centers and affiliated institutions, provides logistical information relevant to the selection of substrates, their respective advantages and di …
A literature review, along with an informal survey and focus group involving individuals at the National Primate Research Cent …
Thread Depth Effects on Stability and Positional Accuracy in Guided Immediate Implants: A Randomized Controlled Trial.
Kwon NY, Jung JY, Ko KA, Park SH, Strauss FJ, Lee JS. Kwon NY, et al. Clin Implant Dent Relat Res. 2026 Apr;28(2):e70145. doi: 10.1111/cid.70145. Clin Implant Dent Relat Res. 2026. PMID: 41978331 Free PMC article. Clinical Trial.
Deeper-thread designs may be beneficial when enhanced primary stability is required, provided careful angulation control is ensured. TRIAL REGISTRATION: cris.nih.go.kr Identifier: KCT0009402; This clinical trial was not registered prior to participant recruitment and rando …
Deeper-thread designs may be beneficial when enhanced primary stability is required, provided careful angulation control is ensured. TRIAL R …
Ubiquitylation of DNA polymerase β via atypical K27 chains signals a DNA damage response.
Fang Q, Koczor CA, Roos WP, McClellan S, Andrews JF, Sobol RW. Fang Q, et al. Nucleic Acids Res. 2026 Apr 13;54(7):gkag344. doi: 10.1093/nar/gkag344. Nucleic Acids Res. 2026. PMID: 41978267 Free PMC article.
These findings demonstrate that atypical ubiquitin chain modifications play crucial roles in DNA repair and the DNA damage response, underscoring the unexpected importance of these chain topologies in maintaining genome integrity....
These findings demonstrate that atypical ubiquitin chain modifications play crucial roles in DNA repair and the DNA damage response, undersc …
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