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2002 3
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2008 5
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2010 9
2011 19
2012 31
2013 27
2014 31
2015 23
2016 15
2017 31
2018 27
2019 25
2020 17
2021 5
2022 2
2024 1
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Page 1
Curating Genetic Associations With Rheumatologic Autoimmune Diseases to Improve Patient Outcomes.
Bridges SL Jr, Shapira R, Aksentijevich I, Mack SJ, Merriman TR, Klein CJ, Bowen BM, Klein TE; ClinGen Rheumatologic Autoimmune Disease Clinical Domain Working Group. Bridges SL Jr, et al. Arthritis Rheumatol. 2024 Nov;76(11):1577-1581. doi: 10.1002/art.42943. Epub 2024 Aug 1. Arthritis Rheumatol. 2024. PMID: 38965695 Free article. No abstract available.
The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms.
Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A, Giacomini KM, Caudle KE, Voora D. Cooper-DeHoff RM, et al. Clin Pharmacol Ther. 2022 May;111(5):1007-1021. doi: 10.1002/cpt.2557. Epub 2022 Mar 11. Clin Pharmacol Ther. 2022. PMID: 35152405 Free PMC article.
Protein sequence design with a learned potential.
Anand N, Eguchi R, Mathews II, Perez CP, Derry A, Altman RB, Huang PS. Anand N, et al. Nat Commun. 2022 Feb 8;13(1):746. doi: 10.1038/s41467-022-28313-9. Nat Commun. 2022. PMID: 35136054 Free PMC article.
Verifying nomenclature of DNA variants in submitted manuscripts: Guidance for journals.
Higgins J, Dalgleish R, den Dunnen JT, Barsh G, Freeman PJ, Cooper DN, Cullinan S, Davies KE, Dorkins H, Gong L, Imoto I, Klein TE, Korf B, Misra A, Paalman MH, Ratzel S, Reichardt JKV, Rehm HL, Tokunaga K, Weck KE, Cutting GR. Higgins J, et al. Hum Mutat. 2021 Jan;42(1):3-7. doi: 10.1002/humu.24144. Epub 2020 Dec 10. Hum Mutat. 2021. PMID: 33252176 Free PMC article.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update.
Karnes JH, Rettie AE, Somogyi AA, Huddart R, Fohner AE, Formea CM, Ta Michael Lee M, Llerena A, Whirl-Carrillo M, Klein TE, Phillips EJ, Mintzer S, Gaedigk A, Caudle KE, Callaghan JT. Karnes JH, et al. Clin Pharmacol Ther. 2021 Feb;109(2):302-309. doi: 10.1002/cpt.2008. Epub 2020 Sep 6. Clin Pharmacol Ther. 2021. PMID: 32779747 Free PMC article.
Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium.
Verma SS, Bergmeijer TO, Gong L, Reny JL, Lewis JP, Mitchell BD, Alexopoulos D, Aradi D, Altman RB, Bliden K, Bradford Y, Campo G, Chang K, Cleator JH, Déry JP, Dridi NP, Fernandez-Cadenas I, Fontana P, Gawaz M, Geisler T, Gensini GF, Giusti B, Gurbel PA, Hochholzer W, Holmvang L, Kim EY, Kim HS, Marcucci R, Montaner J, Backman JD, Pakyz RE, Roden DM, Schaeffeler E, Schwab M, Shin JG, Siller-Matula JM, Ten Berg JM, Trenk D, Valgimigli M, Wallace J, Wen MS, Kubo M, Lee MTM, Whaley R, Winter S, Klein TE, Shuldiner AR, Ritchie MD; ICPC Investigators. Verma SS, et al. Clin Pharmacol Ther. 2020 Nov;108(5):1067-1077. doi: 10.1002/cpt.1911. Epub 2020 Jul 9. Clin Pharmacol Ther. 2020. PMID: 32472697 Free PMC article.
PharmGKB summary: lamotrigine pathway, pharmacokinetics and pharmacodynamics.
Mitra-Ghosh T, Callisto SP, Lamba JK, Remmel RP, Birnbaum AK, Barbarino JM, Klein TE, Altman RB. Mitra-Ghosh T, et al. Pharmacogenet Genomics. 2020 Jun;30(4):81-90. doi: 10.1097/FPC.0000000000000397. Pharmacogenet Genomics. 2020. PMID: 32187155 Free PMC article. Review. No abstract available.
PharmGKB summary: sertraline pathway, pharmacokinetics.
Huddart R, Hicks JK, Ramsey LB, Strawn JR, Smith DM, Bobonis Babilonia M, Altman RB, Klein TE. Huddart R, et al. Pharmacogenet Genomics. 2020 Feb;30(2):26-33. doi: 10.1097/FPC.0000000000000392. Pharmacogenet Genomics. 2020. PMID: 31851125 Free PMC article. No abstract available.
PGxMine: Text mining for curation of PharmGKB.
Lever J, Barbarino JM, Gong L, Huddart R, Sangkuhl K, Whaley R, Whirl-Carrillo M, Woon M, Klein TE, Altman RB. Lever J, et al. Pac Symp Biocomput. 2020;25:611-622. Pac Symp Biocomput. 2020. PMID: 31797632 Free PMC article.
PharmVar and the Landscape of Pharmacogenetic Resources.
Gaedigk A, Whirl-Carrillo M, Pratt VM, Miller NA, Klein TE. Gaedigk A, et al. Clin Pharmacol Ther. 2020 Jan;107(1):43-46. doi: 10.1002/cpt.1654. Epub 2019 Nov 23. Clin Pharmacol Ther. 2020. PMID: 31758698 Free PMC article. No abstract available.
A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy.
Hicks JK, Bishop JR, Gammal RS, Sangkuhl K, Bousman CA, Leeder JS, Llerena A, Mueller DJ, Ramsey LB, Scott SA, Skaar TC, Caudle KE, Klein TE, Gaedigk A. Hicks JK, et al. Clin Pharmacol Ther. 2020 Jan;107(1):50-52. doi: 10.1002/cpt.1661. Epub 2019 Oct 30. Clin Pharmacol Ther. 2020. PMID: 31664715 Free PMC article. No abstract available.
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.
Caudle KE, Sangkuhl K, Whirl-Carrillo M, Swen JJ, Haidar CE, Klein TE, Gammal RS, Relling MV, Scott SA, Hertz DL, Guchelaar HJ, Gaedigk A. Caudle KE, et al. Clin Transl Sci. 2020 Jan;13(1):116-124. doi: 10.1111/cts.12692. Epub 2019 Oct 24. Clin Transl Sci. 2020. PMID: 31647186 Free PMC article.
PharmVar GeneFocus: CYP2D6.
Nofziger C, Turner AJ, Sangkuhl K, Whirl-Carrillo M, Agúndez JAG, Black JL, Dunnenberger HM, Ruano G, Kennedy MA, Phillips MS, Hachad H, Klein TE, Gaedigk A. Nofziger C, et al. Clin Pharmacol Ther. 2020 Jan;107(1):154-170. doi: 10.1002/cpt.1643. Epub 2019 Dec 9. Clin Pharmacol Ther. 2020. PMID: 31544239 Free PMC article. Review.
Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients.
Lewis JP, Backman JD, Reny JL, Bergmeijer TO, Mitchell BD, Ritchie MD, Déry JP, Pakyz RE, Gong L, Ryan K, Kim EY, Aradi D, Fernandez-Cadenas I, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Gawaz M, Bliden KP, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Schwab M, Klein TE, Shuldiner AR; ICPC Investigators. Lewis JP, et al. Eur Heart J Cardiovasc Pharmacother. 2020 Jul 1;6(4):203-210. doi: 10.1093/ehjcvp/pvz045. Eur Heart J Cardiovasc Pharmacother. 2020. PMID: 31504375 Free PMC article.
Pharmacogenomics Clinical Annotation Tool (PharmCAT).
Sangkuhl K, Whirl-Carrillo M, Whaley RM, Woon M, Lavertu A, Altman RB, Carter L, Verma A, Ritchie MD, Klein TE. Sangkuhl K, et al. Clin Pharmacol Ther. 2020 Jan;107(1):203-210. doi: 10.1002/cpt.1568. Epub 2019 Sep 17. Clin Pharmacol Ther. 2020. PMID: 31306493 Free PMC article.
Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges.
McInnes G, Daneshjou R, Katsonis P, Lichtarge O, Srinivasan R, Rana S, Radivojac P, Mooney SD, Pagel KA, Stamboulian M, Jiang Y, Capriotti E, Wang Y, Bromberg Y, Bovo S, Savojardo C, Martelli PL, Casadio R, Pal LR, Moult J, Brenner SE, Altman R. McInnes G, et al. Hum Mutat. 2019 Sep;40(9):1314-1320. doi: 10.1002/humu.23825. Epub 2019 Jun 24. Hum Mutat. 2019. PMID: 31140652 Free PMC article.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.
Desta Z, Gammal RS, Gong L, Whirl-Carrillo M, Gaur AH, Sukasem C, Hockings J, Myers A, Swart M, Tyndale RF, Masimirembwa C, Iwuchukwu OF, Chirwa S, Lennox J, Gaedigk A, Klein TE, Haas DW. Desta Z, et al. Clin Pharmacol Ther. 2019 Oct;106(4):726-733. doi: 10.1002/cpt.1477. Epub 2019 Jul 5. Clin Pharmacol Ther. 2019. PMID: 31006110 Free PMC article.
Considerations for pharmacogenomic testing in a health system.
Gammal RS, Caudle KE, Klein TE, Relling MV. Gammal RS, et al. Genet Med. 2019 Aug;21(8):1886-1887. doi: 10.1038/s41436-018-0421-x. Epub 2019 Jan 9. Genet Med. 2019. PMID: 30631112 Free article. No abstract available.
The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans.
Friedman PN, Shaazuddin M, Gong L, Grossman RL, Harralson AF, Klein TE, Lee NH, Miller DC, Nutescu EA, O'Brien TJ, O'Donnell PH, O'Leary KJ, Tuck M, Meltzer DO, Perera MA. Friedman PN, et al. Clin Transl Sci. 2019 May;12(3):209-217. doi: 10.1111/cts.12608. Epub 2019 Feb 12. Clin Transl Sci. 2019. PMID: 30592548 Free PMC article. Review.
The Evolution of PharmVar.
Gaedigk A, Sangkuhl K, Whirl-Carrillo M, Twist GP, Klein TE, Miller NA; PharmVar Steering Committee. Gaedigk A, et al. Clin Pharmacol Ther. 2019 Jan;105(1):29-32. doi: 10.1002/cpt.1275. Epub 2018 Dec 7. Clin Pharmacol Ther. 2019. PMID: 30536702 Free PMC article. Review. No abstract available.
Pharmacogene Variation Consortium Gene Introduction: NUDT15.
Yang JJ, Whirl-Carrillo M, Scott SA, Turner AJ, Schwab M, Tanaka Y, Suarez-Kurtz G, Schaeffeler E, Klein TE, Miller NA, Gaedigk A. Yang JJ, et al. Clin Pharmacol Ther. 2019 May;105(5):1091-1094. doi: 10.1002/cpt.1268. Epub 2018 Dec 4. Clin Pharmacol Ther. 2019. PMID: 30515762 Free PMC article. No abstract available.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes.
Gonsalves SG, Dirksen RT, Sangkuhl K, Pulk R, Alvarellos M, Vo T, Hikino K, Roden D, Klein TE, Poler SM, Patel S, Caudle KE, Gordon R, Brandom B, Biesecker LG. Gonsalves SG, et al. Clin Pharmacol Ther. 2019 Jun;105(6):1338-1344. doi: 10.1002/cpt.1319. Epub 2019 Jan 24. Clin Pharmacol Ther. 2019. PMID: 30499100 Free PMC article.
The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children.
Gammal RS, Caudle KE, Quinn CT, Wang WC, Gaedigk A, Prows CA, Haidar CE, Taylor AK, Klein TE, Sangkuhl K, Hankins JS, Crews KR. Gammal RS, et al. Clin Pharmacol Ther. 2019 Jun;105(6):1300-1302. doi: 10.1002/cpt.1260. Epub 2018 Nov 22. Clin Pharmacol Ther. 2019. PMID: 30467830 Free PMC article. Review. No abstract available.
Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update.
Relling MV, Schwab M, Whirl-Carrillo M, Suarez-Kurtz G, Pui CH, Stein CM, Moyer AM, Evans WE, Klein TE, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ. Relling MV, et al. Clin Pharmacol Ther. 2019 May;105(5):1095-1105. doi: 10.1002/cpt.1304. Epub 2019 Jan 20. Clin Pharmacol Ther. 2019. PMID: 30447069 Free PMC article.
Essential Characteristics of Pharmacogenomics Study Publications.
Thorn CF, Whirl-Carrillo M, Hachad H, Johnson JA, McDonagh EM, Ratain MJ, Relling MV, Scott SA, Altman RB, Klein TE. Thorn CF, et al. Clin Pharmacol Ther. 2019 Jan;105(1):86-91. doi: 10.1002/cpt.1279. Clin Pharmacol Ther. 2019. PMID: 30406943 Free PMC article. Review.
PharmGKB summary: oxycodone pathway, pharmacokinetics.
Huddart R, Clarke M, Altman RB, Klein TE. Huddart R, et al. Pharmacogenet Genomics. 2018 Oct;28(10):230-237. doi: 10.1097/FPC.0000000000000351. Pharmacogenet Genomics. 2018. PMID: 30222708 Free PMC article. No abstract available.
PharmGKB summary: clozapine pathway, pharmacokinetics.
Thorn CF, Müller DJ, Altman RB, Klein TE. Thorn CF, et al. Pharmacogenet Genomics. 2018 Sep;28(9):214-222. doi: 10.1097/FPC.0000000000000347. Pharmacogenet Genomics. 2018. PMID: 30134346 Free PMC article. No abstract available.
Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).
Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR; ICPC Investigators. Bergmeijer TO, et al. Am Heart J. 2018 Apr;198:152-159. doi: 10.1016/j.ahj.2017.12.010. Epub 2017 Dec 17. Am Heart J. 2018. PMID: 29653637 Free PMC article. Review.
Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.
Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT. Amare AT, et al. Front Psychiatry. 2018 Mar 6;9:65. doi: 10.3389/fpsyt.2018.00065. eCollection 2018. Front Psychiatry. 2018. PMID: 29559929 Free PMC article.
PharmGKB summary: clobazam pathway, pharmacokinetics.
Huddart R, Leeder JS, Altman RB, Klein TE. Huddart R, et al. Pharmacogenet Genomics. 2018 Apr;28(4):110-115. doi: 10.1097/FPC.0000000000000327. Pharmacogenet Genomics. 2018. PMID: 29517622 Free PMC article. No abstract available.
PharmGKB: A worldwide resource for pharmacogenomic information.
Barbarino JM, Whirl-Carrillo M, Altman RB, Klein TE. Barbarino JM, et al. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. doi: 10.1002/wsbm.1417. Epub 2018 Feb 23. Wiley Interdiscip Rev Syst Biol Med. 2018. PMID: 29474005 Free PMC article. Review.
Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.
Volpi S, Bult CJ, Chisholm RL, Deverka PA, Ginsburg GS, Jacob HJ, Kasapi M, McLeod HL, Roden DM, Williams MS, Green ED, Rodriguez LL, Aronson S, Cavallari LH, Denny JC, Dressler LG, Johnson JA, Klein TE, Leeder JS, Piquette-Miller M, Perera M, Rasmussen-Torvik LJ, Rehm HL, Ritchie MD, Skaar TC, Wagle N, Weinshilboum R, Weitzel KW, Wildin R, Wilson J, Manolio TA, Relling MV. Volpi S, et al. Clin Pharmacol Ther. 2018 May;103(5):778-786. doi: 10.1002/cpt.1048. Epub 2018 Mar 30. Clin Pharmacol Ther. 2018. PMID: 29460415 Free PMC article. Review.
Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.
Phillips EJ, Sukasem C, Whirl-Carrillo M, Müller DJ, Dunnenberger HM, Chantratita W, Goldspiel B, Chen YT, Carleton BC, George AL Jr, Mushiroda T, Klein T, Gammal RS, Pirmohamed M. Phillips EJ, et al. Clin Pharmacol Ther. 2018 Apr;103(4):574-581. doi: 10.1002/cpt.1004. Epub 2018 Feb 2. Clin Pharmacol Ther. 2018. PMID: 29392710 Free PMC article.
PharmCAT: A Pharmacogenomics Clinical Annotation Tool.
Klein TE, Ritchie MD. Klein TE, et al. Clin Pharmacol Ther. 2018 Jul;104(1):19-22. doi: 10.1002/cpt.928. Epub 2017 Dec 1. Clin Pharmacol Ther. 2018. PMID: 29194583 Free PMC article.
PharmGKB summary: very important pharmacogene information for ABCG2.
Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE. Fohner AE, et al. Pharmacogenet Genomics. 2017 Nov;27(11):420-427. doi: 10.1097/FPC.0000000000000305. Pharmacogenet Genomics. 2017. PMID: 28858993 Free PMC article. Review. No abstract available.
PharmGKB summary: pazopanib pathway, pharmacokinetics.
Thorn CF, Sharma MR, Altman RB, Klein TE. Thorn CF, et al. Pharmacogenet Genomics. 2017 Aug;27(8):307-312. doi: 10.1097/FPC.0000000000000292. Pharmacogenet Genomics. 2017. PMID: 28678138 Free PMC article. Review. No abstract available.
Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges.
Daneshjou R, Wang Y, Bromberg Y, Bovo S, Martelli PL, Babbi G, Lena PD, Casadio R, Edwards M, Gifford D, Jones DT, Sundaram L, Bhat RR, Li X, Pal LR, Kundu K, Yin Y, Moult J, Jiang Y, Pejaver V, Pagel KA, Li B, Mooney SD, Radivojac P, Shah S, Carraro M, Gasparini A, Leonardi E, Giollo M, Ferrari C, Tosatto SCE, Bachar E, Azaria JR, Ofran Y, Unger R, Niroula A, Vihinen M, Chang B, Wang MH, Franke A, Petersen BS, Pirooznia M, Zandi P, McCombie R, Potash JB, Altman RB, Klein TE, Hoskins RA, Repo S, Brenner SE, Morgan AA. Daneshjou R, et al. Hum Mutat. 2017 Sep;38(9):1182-1192. doi: 10.1002/humu.23280. Epub 2017 Jul 7. Hum Mutat. 2017. PMID: 28634997 Free PMC article.
Pharmacogenomics-Based Point-of-Care Clinical Decision Support Significantly Alters Drug Prescribing.
O'Donnell PH, Wadhwa N, Danahey K, Borden BA, Lee SM, Hall JP, Klammer C, Hussain S, Siegler M, Sorrentino MJ, Davis AM, Sacro YA, Nanda R, Polonsky TS, Koyner JL, Burnet DL, Lipstreuer K, Rubin DT, Mulcahy C, Strek ME, Harper W, Cifu AS, Polite B, Patrick-Miller L, Yeo KT, Leung E, Volchenboum SL, Altman RB, Olopade OI, Stadler WM, Meltzer DO, Ratain MJ. O'Donnell PH, et al. Clin Pharmacol Ther. 2017 Nov;102(5):859-869. doi: 10.1002/cpt.709. Epub 2017 Jun 15. Clin Pharmacol Ther. 2017. PMID: 28398598 Free PMC article.
PharmGKB summary: sorafenib pathways.
Gong L, Giacomini MM, Giacomini C, Maitland ML, Altman RB, Klein TE. Gong L, et al. Pharmacogenet Genomics. 2017 Jun;27(6):240-246. doi: 10.1097/FPC.0000000000000279. Pharmacogenet Genomics. 2017. PMID: 28362716 Free PMC article. Review. No abstract available.
PharmGKB summary: voriconazole pathway, pharmacokinetics.
Barbarino JM, Owusu Obeng A, Klein TE, Altman RB. Barbarino JM, et al. Pharmacogenet Genomics. 2017 May;27(5):201-209. doi: 10.1097/FPC.0000000000000276. Pharmacogenet Genomics. 2017. PMID: 28277330 Free PMC article. No abstract available.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update.
Johnson JA, Caudle KE, Gong L, Whirl-Carrillo M, Stein CM, Scott SA, Lee MT, Gage BF, Kimmel SE, Perera MA, Anderson JL, Pirmohamed M, Klein TE, Limdi NA, Cavallari LH, Wadelius M. Johnson JA, et al. Clin Pharmacol Ther. 2017 Sep;102(3):397-404. doi: 10.1002/cpt.668. Epub 2017 Apr 4. Clin Pharmacol Ther. 2017. PMID: 28198005 Free PMC article.
The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems.
Luzum JA, Pakyz RE, Elsey AR, Haidar CE, Peterson JF, Whirl-Carrillo M, Handelman SK, Palmer K, Pulley JM, Beller M, Schildcrout JS, Field JR, Weitzel KW, Cooper-DeHoff RM, Cavallari LH, O'Donnell PH, Altman RB, Pereira N, Ratain MJ, Roden DM, Embi PJ, Sadee W, Klein TE, Johnson JA, Relling MV, Wang L, Weinshilboum RM, Shuldiner AR, Freimuth RR; Pharmacogenomics Research Network Translational Pharmacogenetics Program. Luzum JA, et al. Clin Pharmacol Ther. 2017 Sep;102(3):502-510. doi: 10.1002/cpt.630. Epub 2017 Jun 9. Clin Pharmacol Ther. 2017. PMID: 28090649 Free PMC article.
Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC. Hicks JK, et al. Clin Pharmacol Ther. 2017 Jul;102(1):37-44. doi: 10.1002/cpt.597. Epub 2017 Feb 13. Clin Pharmacol Ther. 2017. PMID: 27997040 Free PMC article.
Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics.
Kalia SS, Adelman K, Bale SJ, Chung WK, Eng C, Evans JP, Herman GE, Hufnagel SB, Klein TE, Korf BR, McKelvey KD, Ormond KE, Richards CS, Vlangos CN, Watson M, Martin CL, Miller DT. Kalia SS, et al. Genet Med. 2017 Feb;19(2):249-255. doi: 10.1038/gim.2016.190. Epub 2016 Nov 17. Genet Med. 2017. PMID: 27854360 Free article.
PharmGKB summary: very important pharmacogene information for MT-RNR1.
Barbarino JM, McGregor TL, Altman RB, Klein TE. Barbarino JM, et al. Pharmacogenet Genomics. 2016 Dec;26(12):558-567. doi: 10.1097/FPC.0000000000000247. Pharmacogenet Genomics. 2016. PMID: 27654872 Free PMC article. Review. No abstract available.
Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans.
Daneshjou R, Cavallari LH, Weeke PE, Karczewski KJ, Drozda K, Perera MA, Johnson JA, Klein TE, Bustamante CD, Roden DM, Shaffer C, Denny JC, Zehnder JL, Altman RB. Daneshjou R, et al. Mol Genet Genomic Med. 2016 Jun 21;4(5):513-20. doi: 10.1002/mgg3.226. eCollection 2016 Sep. Mol Genet Genomic Med. 2016. PMID: 27652279 Free PMC article.
PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics.
Fohner AE, McDonagh EM, Clancy JP, Whirl Carrillo M, Altman RB, Klein TE. Fohner AE, et al. Pharmacogenet Genomics. 2017 Jan;27(1):39-42. doi: 10.1097/FPC.0000000000000246. Pharmacogenet Genomics. 2017. PMID: 27636560 Free PMC article. No abstract available.
PharmGKB summary: isoniazid pathway, pharmacokinetics.
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE. Klein DJ, et al. Pharmacogenet Genomics. 2016 Sep;26(9):436-44. doi: 10.1097/FPC.0000000000000232. Pharmacogenet Genomics. 2016. PMID: 27232112 Free PMC article. No abstract available.
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC. Burridge PW, et al. Nat Med. 2016 May;22(5):547-56. doi: 10.1038/nm.4087. Epub 2016 Apr 18. Nat Med. 2016. PMID: 27089514 Free PMC article.
PharmGKB summary: very important pharmacogene information for RYR1.
Alvarellos ML, Krauss RM, Wilke RA, Altman RB, Klein TE. Alvarellos ML, et al. Pharmacogenet Genomics. 2016 Mar;26(3):138-44. doi: 10.1097/FPC.0000000000000198. Pharmacogenet Genomics. 2016. PMID: 26709912 Free PMC article. Review. No abstract available.
Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.
Kalman LV, Agúndez J, Appell ML, Black JL, Bell GC, Boukouvala S, Bruckner C, Bruford E, Caudle K, Coulthard SA, Daly AK, Del Tredici A, den Dunnen JT, Drozda K, Everts RE, Flockhart D, Freimuth RR, Gaedigk A, Hachad H, Hartshorne T, Ingelman-Sundberg M, Klein TE, Lauschke VM, Maglott DR, McLeod HL, McMillin GA, Meyer UA, Müller DJ, Nickerson DA, Oetting WS, Pacanowski M, Pratt VM, Relling MV, Roberts A, Rubinstein WS, Sangkuhl K, Schwab M, Scott SA, Sim SC, Thirumaran RK, Toji LH, Tyndale RF, van Schaik R, Whirl-Carrillo M, Yeo K, Zanger UM. Kalman LV, et al. Clin Pharmacol Ther. 2016 Feb;99(2):172-85. doi: 10.1002/cpt.280. Epub 2015 Nov 20. Clin Pharmacol Ther. 2016. PMID: 26479518 Free PMC article. Review.
Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data.
Dewey FE, Grove ME, Priest JR, Waggott D, Batra P, Miller CL, Wheeler M, Zia A, Pan C, Karzcewski KJ, Miyake C, Whirl-Carrillo M, Klein TE, Datta S, Altman RB, Snyder M, Quertermous T, Ashley EA. Dewey FE, et al. PLoS Genet. 2015 Oct 8;11(10):e1005496. doi: 10.1371/journal.pgen.1005496. eCollection 2015 Oct. PLoS Genet. 2015. PMID: 26448358 Free PMC article.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing.
Gammal RS, Court MH, Haidar CE, Iwuchukwu OF, Gaur AH, Alvarellos M, Guillemette C, Lennox JL, Whirl-Carrillo M, Brummel SS, Ratain MJ, Klein TE, Schackman BR, Caudle KE, Haas DW; Clinical Pharmacogenetics Implementation Consortium. Gammal RS, et al. Clin Pharmacol Ther. 2016 Apr;99(4):363-9. doi: 10.1002/cpt.269. Epub 2015 Nov 9. Clin Pharmacol Ther. 2016. PMID: 26417955 Free PMC article.
Genome-wide association study of warfarin maintenance dose in a Brazilian sample.
Parra EJ, Botton MR, Perini JA, Krithika S, Bourgeois S, Johnson TA, Tsunoda T, Pirmohamed M, Wadelius M, Limdi NA, Cavallari LH, Burmester JK, Rettie AE, Klein TE, Johnson JA, Hutz MH, Suarez-Kurtz G. Parra EJ, et al. Pharmacogenomics. 2015;16(11):1253-63. doi: 10.2217/PGS.15.73. Epub 2015 Aug 12. Pharmacogenomics. 2015. PMID: 26265036 Free PMC article.
PharmGKB summary: peginterferon-α pathway.
Shuldiner SR, Gong L, Muir AJ, Altman RB, Klein TE. Shuldiner SR, et al. Pharmacogenet Genomics. 2015 Sep;25(9):465-74. doi: 10.1097/FPC.0000000000000158. Pharmacogenet Genomics. 2015. PMID: 26111151 Free PMC article. No abstract available.
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for human leukocyte antigen B (HLA-B) genotype and allopurinol dosing: 2015 update.
Saito Y, Stamp LK, Caudle KE, Hershfield MS, McDonagh EM, Callaghan JT, Tassaneeyakul W, Mushiroda T, Kamatani N, Goldspiel BR, Phillips EJ, Klein TE, Lee MT; Clinical Pharmacogenetics Implementation Consortium. Saito Y, et al. Clin Pharmacol Ther. 2016 Jan;99(1):36-7. doi: 10.1002/cpt.161. Epub 2015 Jul 16. Clin Pharmacol Ther. 2016. PMID: 26094938 Free PMC article.
Evidence for Clinical Implementation of Pharmacogenomics in Cardiac Drugs.
Kaufman AL, Spitz J, Jacobs M, Sorrentino M, Yuen S, Danahey K, Saner D, Klein TE, Altman RB, Ratain MJ, O'Donnell PH. Kaufman AL, et al. Mayo Clin Proc. 2015 Jun;90(6):716-29. doi: 10.1016/j.mayocp.2015.03.016. Mayo Clin Proc. 2015. PMID: 26046407 Free PMC article.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
Hicks JK, Bishop JR, Sangkuhl K, Müller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A; Clinical Pharmacogenetics Implementation Consortium. Hicks JK, et al. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29. Clin Pharmacol Ther. 2015. PMID: 25974703 Free PMC article.
PharmGKB summary: Efavirenz pathway, pharmacokinetics.
McDonagh EM, Lau JL, Alvarellos ML, Altman RB, Klein TE. McDonagh EM, et al. Pharmacogenet Genomics. 2015 Jul;25(7):363-76. doi: 10.1097/FPC.0000000000000145. Pharmacogenet Genomics. 2015. PMID: 25966836 Free PMC article. Review. No abstract available.
The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.
Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R. Biernacka JM, et al. Transl Psychiatry. 2015 Apr 21;5(4):e553. doi: 10.1038/tp.2015.47. Transl Psychiatry. 2015. PMID: 25897834 Free PMC article.
Ranking adverse drug reactions with crowdsourcing.
Gottlieb A, Hoehndorf R, Dumontier M, Altman RB. Gottlieb A, et al. J Med Internet Res. 2015 Mar 23;17(3):e80. doi: 10.2196/jmir.3962. J Med Internet Res. 2015. PMID: 25800813 Free PMC article.
Enabling the curation of your pharmacogenetic study.
McDonagh Em, Whirl-Carrillo M, Altman RB, Klein TE. McDonagh Em, et al. Clin Pharmacol Ther. 2015 Feb;97(2):116-9. doi: 10.1002/cpt.15. Epub 2014 Dec 20. Clin Pharmacol Ther. 2015. PMID: 25670512 Free PMC article.
PharmGKB summary: very important pharmacogene information for CFTR.
McDonagh EM, Clancy JP, Altman RB, Klein TE. McDonagh EM, et al. Pharmacogenet Genomics. 2015 Mar;25(3):149-56. doi: 10.1097/FPC.0000000000000112. Pharmacogenet Genomics. 2015. PMID: 25514096 Free PMC article. No abstract available.
PharmGKB summary: ibuprofen pathways.
Mazaleuskaya LL, Theken KN, Gong L, Thorn CF, FitzGerald GA, Altman RB, Klein TE. Mazaleuskaya LL, et al. Pharmacogenet Genomics. 2015 Feb;25(2):96-106. doi: 10.1097/FPC.0000000000000113. Pharmacogenet Genomics. 2015. PMID: 25502615 Free PMC article. No abstract available.
PharmGKB summary: very important pharmacogene information for CYP4F2.
Alvarellos ML, Sangkuhl K, Daneshjou R, Whirl-Carrillo M, Altman RB, Klein TE. Alvarellos ML, et al. Pharmacogenet Genomics. 2015 Jan;25(1):41-7. doi: 10.1097/FPC.0000000000000100. Pharmacogenet Genomics. 2015. PMID: 25370453 Free PMC article. Review. No abstract available.
PharmGKB summary: gemcitabine pathway.
Alvarellos ML, Lamba J, Sangkuhl K, Thorn CF, Wang L, Klein DJ, Altman RB, Klein TE. Alvarellos ML, et al. Pharmacogenet Genomics. 2014 Nov;24(11):564-74. doi: 10.1097/FPC.0000000000000086. Pharmacogenet Genomics. 2014. PMID: 25162786 Free PMC article. No abstract available.
Evidence synthesis and guideline development in genomic medicine: current status and future prospects.
Schully SD, Lam TK, Dotson WD, Chang CQ, Aronson N, Birkeland ML, Brewster SJ, Boccia S, Buchanan AH, Calonge N, Calzone K, Djulbegovic B, Goddard KA, Klein RD, Klein TE, Lau J, Long R, Lyman GH, Morgan RL, Palmer CG, Relling MV, Rubinstein WS, Swen JJ, Terry SF, Williams MS, Khoury MJ. Schully SD, et al. Genet Med. 2015 Jan;17(1):63-7. doi: 10.1038/gim.2014.69. Epub 2014 Jun 19. Genet Med. 2015. PMID: 24946156 Free PMC article.
The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.
Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M. Ramsey LB, et al. Clin Pharmacol Ther. 2014 Oct;96(4):423-8. doi: 10.1038/clpt.2014.125. Epub 2014 Jun 11. Clin Pharmacol Ther. 2014. PMID: 24918167 Free PMC article.
PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics.
McDonagh EM, Thorn CF, Callaghan JT, Altman RB, Klein TE. McDonagh EM, et al. Pharmacogenet Genomics. 2014 Sep;24(9):464-76. doi: 10.1097/FPC.0000000000000058. Pharmacogenet Genomics. 2014. PMID: 24915143 Free PMC article. Review. No abstract available.
PharmGKB summary: tramadol pathway.
Gong L, Stamer UM, Tzvetkov MV, Altman RB, Klein TE. Gong L, et al. Pharmacogenet Genomics. 2014 Jul;24(7):374-80. doi: 10.1097/FPC.0000000000000057. Pharmacogenet Genomics. 2014. PMID: 24849324 Free PMC article. No abstract available.
Genotype-guided dosing of vitamin K antagonists.
Daneshjou R, Klein TE, Altman RB. Daneshjou R, et al. N Engl J Med. 2014 May 1;370(18):1762-3. doi: 10.1056/NEJMc1402521. N Engl J Med. 2014. PMID: 24785217 Free PMC article. No abstract available.
PharmGKB summary: abacavir pathway.
Barbarino JM, Kroetz DL, Altman RB, Klein TE. Barbarino JM, et al. Pharmacogenet Genomics. 2014 May;24(5):276-82. doi: 10.1097/FPC.0000000000000040. Pharmacogenet Genomics. 2014. PMID: 24625462 Free PMC article. No abstract available.
Clinical interpretation and implications of whole-genome sequencing.
Dewey FE, Grove ME, Pan C, Goldstein BA, Bernstein JA, Chaib H, Merker JD, Goldfeder RL, Enns GM, David SP, Pakdaman N, Ormond KE, Caleshu C, Kingham K, Klein TE, Whirl-Carrillo M, Sakamoto K, Wheeler MT, Butte AJ, Ford JM, Boxer L, Ioannidis JP, Yeung AC, Altman RB, Assimes TL, Snyder M, Ashley EA, Quertermous T. Dewey FE, et al. JAMA. 2014 Mar 12;311(10):1035-45. doi: 10.1001/jama.2014.1717. JAMA. 2014. PMID: 24618965 Free PMC article.
PharmGKB summary: very important pharmacogene information for UGT1A1.
Barbarino JM, Haidar CE, Klein TE, Altman RB. Barbarino JM, et al. Pharmacogenet Genomics. 2014 Mar;24(3):177-83. doi: 10.1097/FPC.0000000000000024. Pharmacogenet Genomics. 2014. PMID: 24492252 Free PMC article. Review. No abstract available.
Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process.
Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, Gong L, McDonagh EM, Sangkuhl K, Thorn CF, Schwab M, Agundez JA, Freimuth RR, Huser V, Lee MT, Iwuchukwu OF, Crews KR, Scott SA, Wadelius M, Swen JJ, Tyndale RF, Stein CM, Roden D, Relling MV, Williams MS, Johnson SG. Caudle KE, et al. Curr Drug Metab. 2014 Feb;15(2):209-17. doi: 10.2174/1389200215666140130124910. Curr Drug Metab. 2014. PMID: 24479687 Free PMC article.
Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC; Clinical Pharmacogenetics Implementation Consortium. Crews KR, et al. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. Clin Pharmacol Ther. 2014. PMID: 24458010 Free PMC article.
Re: CYP2D6 genotyping and the use of tamoxifen in breast cancer.
Province MA, Klein TE; International Tamoxifen Pharmacogenomics Consortium. Province MA, et al. J Natl Cancer Inst. 2014 Feb;106(2):djt379. doi: 10.1093/jnci/djt379. Epub 2014 Jan 9. J Natl Cancer Inst. 2014. PMID: 24408655 Free PMC article. No abstract available.
PharmGKB summary: mycophenolic acid pathway.
Lamba V, Sangkuhl K, Sanghavi K, Fish A, Altman RB, Klein TE. Lamba V, et al. Pharmacogenet Genomics. 2014 Jan;24(1):73-9. doi: 10.1097/FPC.0000000000000010. Pharmacogenet Genomics. 2014. PMID: 24220207 Free PMC article. Review. No abstract available.
PharmGKB summary: venlafaxine pathway.
Sangkuhl K, Stingl JC, Turpeinen M, Altman RB, Klein TE. Sangkuhl K, et al. Pharmacogenet Genomics. 2014 Jan;24(1):62-72. doi: 10.1097/FPC.0000000000000003. Pharmacogenet Genomics. 2014. PMID: 24128936 Free PMC article. Review. No abstract available.
CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.
Province MA, Goetz MP, Brauch H, Flockhart DA, Hebert JM, Whaley R, Suman VJ, Schroth W, Winter S, Zembutsu H, Mushiroda T, Newman WG, Lee MT, Ambrosone CB, Beckmann MW, Choi JY, Dieudonné AS, Fasching PA, Ferraldeschi R, Gong L, Haschke-Becher E, Howell A, Jordan LB, Hamann U, Kiyotani K, Krippl P, Lambrechts D, Latif A, Langsenlehner U, Lorizio W, Neven P, Nguyen AT, Park BW, Purdie CA, Quinlan P, Renner W, Schmidt M, Schwab M, Shin JG, Stingl JC, Wegman P, Wingren S, Wu AH, Ziv E, Zirpoli G, Thompson AM, Jordan VC, Nakamura Y, Altman RB, Ames MM, Weinshilboum RM, Eichelbaum M, Ingle JN, Klein TE; International Tamoxifen Pharmacogenomics Consortium. Province MA, et al. Clin Pharmacol Ther. 2014 Feb;95(2):216-27. doi: 10.1038/clpt.2013.186. Epub 2013 Sep 23. Clin Pharmacol Ther. 2014. PMID: 24060820 Free PMC article.
PharmGKB summary: tamoxifen pathway, pharmacokinetics.
Klein DJ, Thorn CF, Desta Z, Flockhart DA, Altman RB, Klein TE. Klein DJ, et al. Pharmacogenet Genomics. 2013 Nov;23(11):643-7. doi: 10.1097/FPC.0b013e3283656bc1. Pharmacogenet Genomics. 2013. PMID: 23962908 Free PMC article. Review. No abstract available.
Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion.
David SP, Strong DR, Leventhal AM, Lancaster MA, McGeary JE, Munafò MR, Bergen AW, Swan GE, Benowitz NL, Tyndale RF, Conti DV, Brown RA, Lerman C, Niaura R. David SP, et al. Addiction. 2013 Dec;108(12):2202-11. doi: 10.1111/add.12325. Epub 2013 Sep 18. Addiction. 2013. PMID: 23941313 Free PMC article. Clinical Trial.
PharmGKB summary: cyclosporine and tacrolimus pathways.
Barbarino JM, Staatz CE, Venkataramanan R, Klein TE, Altman RB. Barbarino JM, et al. Pharmacogenet Genomics. 2013 Oct;23(10):563-85. doi: 10.1097/FPC.0b013e328364db84. Pharmacogenet Genomics. 2013. PMID: 23922006 Free PMC article. Review. No abstract available.
PharmGKB summary: methylene blue pathway.
McDonagh EM, Bautista JM, Youngster I, Altman RB, Klein TE. McDonagh EM, et al. Pharmacogenet Genomics. 2013 Sep;23(9):498-508. doi: 10.1097/FPC.0b013e32836498f4. Pharmacogenet Genomics. 2013. PMID: 23913015 Free PMC article. No abstract available.
PharmGKB: the Pharmacogenomics Knowledge Base.
Thorn CF, Klein TE, Altman RB. Thorn CF, et al. Methods Mol Biol. 2013;1015:311-20. doi: 10.1007/978-1-62703-435-7_20. Methods Mol Biol. 2013. PMID: 23824865 Free PMC article.
Improving data and knowledge management to better integrate health care and research.
Cases M, Furlong LI, Albanell J, Altman RB, Bellazzi R, Boyer S, Brand A, Brookes AJ, Brunak S, Clark TW, Gea J, Ghazal P, Graf N, Guigó R, Klein TE, López-Bigas N, Maojo V, Mons B, Musen M, Oliveira JL, Rowe A, Ruch P, Shabo A, Shortliffe EH, Valencia A, van der Lei J, Mayer MA, Sanz F. Cases M, et al. J Intern Med. 2013 Oct;274(4):321-8. doi: 10.1111/joim.12105. Epub 2013 Jul 15. J Intern Med. 2013. PMID: 23808970 Free PMC article. No abstract available.
PharmGKB summary: Diuretics pathway, pharmacodynamics.
Thorn CF, Ellison DH, Turner ST, Altman RB, Klein TE. Thorn CF, et al. Pharmacogenet Genomics. 2013 Aug;23(8):449-53. doi: 10.1097/FPC.0b013e3283636822. Pharmacogenet Genomics. 2013. PMID: 23788015 Free PMC article. No abstract available.
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y, Burkley BM, Desnick RJ, Halperin JL, Khalifa SI, Langaee TY, Lubitz SA, Nutescu EA, Oetjens M, Shahin MH, Patel SR, Sagreiya H, Tector M, Weck KE, Rieder MJ, Scott SA, Wu AH, Burmester JK, Wadelius M, Deloukas P, Wagner MJ, Mushiroda T, Kubo M, Roden DM, Cox NJ, Altman RB, Klein TE, Nakamura Y, Johnson JA. Perera MA, et al. Lancet. 2013 Aug 31;382(9894):790-6. doi: 10.1016/S0140-6736(13)60681-9. Epub 2013 Jun 5. Lancet. 2013. PMID: 23755828 Free PMC article.
Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing.
Leckband SG, Kelsoe JR, Dunnenberger HM, George AL Jr, Tran E, Berger R, Müller DJ, Whirl-Carrillo M, Caudle KE, Pirmohamed M; Clinical Pharmacogenetics Implementation Consortium. Leckband SG, et al. Clin Pharmacol Ther. 2013 Sep;94(3):324-8. doi: 10.1038/clpt.2013.103. Epub 2013 May 21. Clin Pharmacol Ther. 2013. PMID: 23695185 Free PMC article.
The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.
Shuldiner AR, Relling MV, Peterson JF, Hicks JK, Freimuth RR, Sadee W, Pereira NL, Roden DM, Johnson JA, Klein TE; Pharmacogenomics Research Network Translational Pharmacogenetics Program Group; Shuldiner AR, Vesely M, Robinson SW, Ambulos N Jr, Stass SA, Kelemen MD, Brown LA, Pollin TI, Beitelshees AL, Zhao RY, Pakyz RE, Palmer K, Alestock T, O'Neill C, Maloney K, Branham A, Sewell D, Relling MV, Crews K, Hoffman J, Cross S, Haidar C, Baker D, Hicks JK, Bell G, Greeson F, Gaur A, Reiss U, Huettel A, Cheng C, Gajjar A, Pappo A, Howard S, Hudson M, Pui CH, Jeha S, Evans WE, Broeckel U, Altman RB, Gong L, Whirl-Carrillo M, Klein TE, Sadee W, Manickam K, Sweet KM, Embi PJ, Roden D, Peterson J, Denny J, Schildcrout J, Bowton E, Pulley J, Beller M, Mitchell J, Danciu I, Price L, Pereira NL, Weinshilboum R, Wang L, Johnson JA, Nelson D, Clare-Salzler M, Elsey A, Burkley B, Langaee T, Liu F, Nessl D, Dong HJ, Lesko L, Freimuth RR, Chute CG. Shuldiner AR, et al. Clin Pharmacol Ther. 2013 Aug;94(2):207-10. doi: 10.1038/clpt.2013.59. Epub 2013 Mar 19. Clin Pharmacol Ther. 2013. PMID: 23588301 Free PMC article.
Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants.
Hicks JK, Swen JJ, Thorn CF, Sangkuhl K, Kharasch ED, Ellingrod VL, Skaar TC, Müller DJ, Gaedigk A, Stingl JC; Clinical Pharmacogenetics Implementation Consortium. Hicks JK, et al. Clin Pharmacol Ther. 2013 May;93(5):402-8. doi: 10.1038/clpt.2013.2. Epub 2013 Jan 16. Clin Pharmacol Ther. 2013. PMID: 23486447 Free PMC article.
Nomenclature for alleles of the thiopurine methyltransferase gene.
Appell ML, Berg J, Duley J, Evans WE, Kennedy MA, Lennard L, Marinaki T, McLeod HL, Relling MV, Schaeffeler E, Schwab M, Weinshilboum R, Yeoh AE, McDonagh EM, Hebert JM, Klein TE, Coulthard SA. Appell ML, et al. Pharmacogenet Genomics. 2013 Apr;23(4):242-8. doi: 10.1097/FPC.0b013e32835f1cc0. Pharmacogenet Genomics. 2013. PMID: 23407052 Free PMC article.
Valproic acid pathway: pharmacokinetics and pharmacodynamics.
Ghodke-Puranik Y, Thorn CF, Lamba JK, Leeder JS, Song W, Birnbaum AK, Altman RB, Klein TE. Ghodke-Puranik Y, et al. Pharmacogenet Genomics. 2013 Apr;23(4):236-41. doi: 10.1097/FPC.0b013e32835ea0b2. Pharmacogenet Genomics. 2013. PMID: 23407051 Free PMC article. No abstract available.
Chapter 7: Pharmacogenomics.
Karczewski KJ, Daneshjou R, Altman RB. Karczewski KJ, et al. PLoS Comput Biol. 2012;8(12):e1002817. doi: 10.1371/journal.pcbi.1002817. Epub 2012 Dec 27. PLoS Comput Biol. 2012. PMID: 23300409 Free PMC article.
Pharmacogenomics knowledge for personalized medicine.
Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE. Whirl-Carrillo M, et al. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. Clin Pharmacol Ther. 2012. PMID: 22992668 Free PMC article. Review.
PharmGKB summary: zidovudine pathway.
Ghodke Y, Anderson PL, Sangkuhl K, Lamba J, Altman RB, Klein TE. Ghodke Y, et al. Pharmacogenet Genomics. 2012 Dec;22(12):891-4. doi: 10.1097/FPC.0b013e32835879a8. Pharmacogenet Genomics. 2012. PMID: 22960662 Free PMC article. No abstract available.
Metformin pathways: pharmacokinetics and pharmacodynamics.
Gong L, Goswami S, Giacomini KM, Altman RB, Klein TE. Gong L, et al. Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22. Pharmacogenet Genomics. 2012. PMID: 22722338 Free PMC article. Review. No abstract available.
The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.
Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-Dehoff RM, Gong L, Klein TE, Wadelius M, Niemi M; Clinical Pharmacogenomics Implementation Consortium (CPIC). Wilke RA, et al. Clin Pharmacol Ther. 2012 Jul;92(1):112-7. doi: 10.1038/clpt.2012.57. Epub 2012 May 23. Clin Pharmacol Ther. 2012. PMID: 22617227 Free PMC article.
Very important pharmacogene summary for VDR.
Poon AH, Gong L, Brasch-Andersen C, Litonjua AA, Raby BA, Hamid Q, Laprise C, Weiss ST, Altman RB, Klein TE. Poon AH, et al. Pharmacogenet Genomics. 2012 Oct;22(10):758-63. doi: 10.1097/FPC.0b013e328354455c. Pharmacogenet Genomics. 2012. PMID: 22588316 Free PMC article. Review. No abstract available.
PharmGKB summary: phenytoin pathway.
Thorn CF, Whirl-Carrillo M, Leeder JS, Klein TE, Altman RB. Thorn CF, et al. Pharmacogenet Genomics. 2012 Jun;22(6):466-70. doi: 10.1097/FPC.0b013e32834aeedb. Pharmacogenet Genomics. 2012. PMID: 22569204 Free PMC article. Review. No abstract available.
Clopidogrel: a case for indication-specific pharmacogenetics.
Johnson JA, Roden DM, Lesko LJ, Ashley E, Klein TE, Shuldiner AR. Johnson JA, et al. Clin Pharmacol Ther. 2012 May;91(5):774-6. doi: 10.1038/clpt.2012.21. Clin Pharmacol Ther. 2012. PMID: 22513313 Free PMC article.
Personal omics profiling reveals dynamic molecular and medical phenotypes.
Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M. Chen R, et al. Cell. 2012 Mar 16;148(6):1293-307. doi: 10.1016/j.cell.2012.02.009. Cell. 2012. PMID: 22424236 Free PMC article.
Data-driven prediction of drug effects and interactions.
Tatonetti NP, Ye PP, Daneshjou R, Altman RB. Tatonetti NP, et al. Sci Transl Med. 2012 Mar 14;4(125):125ra31. doi: 10.1126/scitranslmed.3003377. Sci Transl Med. 2012. PMID: 22422992 Free PMC article.
Celecoxib pathways: pharmacokinetics and pharmacodynamics.
Gong L, Thorn CF, Bertagnolli MM, Grosser T, Altman RB, Klein TE. Gong L, et al. Pharmacogenet Genomics. 2012 Apr;22(4):310-8. doi: 10.1097/FPC.0b013e32834f94cb. Pharmacogenet Genomics. 2012. PMID: 22336956 Free PMC article. No abstract available.
PharmGKB summary: caffeine pathway.
Thorn CF, Aklillu E, McDonagh EM, Klein TE, Altman RB. Thorn CF, et al. Pharmacogenet Genomics. 2012 May;22(5):389-95. doi: 10.1097/FPC.0b013e3283505d5e. Pharmacogenet Genomics. 2012. PMID: 22293536 Free PMC article. No abstract available.
PharmGKB summary: very important pharmacogene information for G6PD.
McDonagh EM, Thorn CF, Bautista JM, Youngster I, Altman RB, Klein TE. McDonagh EM, et al. Pharmacogenet Genomics. 2012 Mar;22(3):219-28. doi: 10.1097/FPC.0b013e32834eb313. Pharmacogenet Genomics. 2012. PMID: 22237549 Free PMC article. No abstract available.
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.
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