U24 CA114766/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2007	1
2008	2
2009	5
2010	11
2011	13
2012	27
2013	26
2014	22
2015	29
2016	23
2017	16
2018	23
2019	16
2020	13
2021	11
2022	14
2023	21
2024	19
2025	8

1

Performance of Two-Phase Designs for the Time-to-Event Outcome and a Case Study Assessing the Relapse Risk Associated With B-ALL Subtypes.

Chen W, Chang TC, Rabin KR, Raetz EA, Devidas M, Hunger SP, Ramirez NC, Mullighan CG, Loh ML, Wu G. Chen W, et al. JCO Clin Cancer Inform. 2025 May;9:e2400223. doi: 10.1200/CCI-24-00223. Epub 2025 May 2. JCO Clin Cancer Inform. 2025. PMID: 40315406 Free PMC article.

2

STAT1-mediated interferon signatures are associated with preclinical JAK inhibitor sensitivity in T-ALL.

Xu J, Sussman JH, Yang A, Yoshimura S, Hu J, Chen C, Vincent T, Bandyopadhyay S, Li EY, Lim T, Elghawy O, Barsouk A, Karanfilovski D, Wald SL, Chen GM, Wu D, Newman H, Li A, Sun Y, Chen CH, Bernt K, Wood BL, Winter SS, Dunsmore KP, Raetz E, Devidas M, Pounds S, Loh M, Hunger SP, Chiang MY, Diorio C, Di Giacomo D, Pölönen P, Mullighan CG, Yang JJ, Tan K, Teachey DT. Xu J, et al. Blood. 2025 Jun 5;145(23):2793-2798. doi: 10.1182/blood.2025028566. Blood. 2025. PMID: 40101143

3

Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome.

Chen C, Xu J, Sussman JH, Vincent T, Tumulty JS, Yoshimura S, Alikarami F, Yu W, Ding YY, Chen CH, Li EY, Yang A, Qin X, Bandyopadhyay S, Peng J, Pölönen P, Newman H, Wood BL, Hu J, Shraim R, Hughes AD, Diorio C, Uppuluri L, Shi G, Ryan T, Fuller T, Loh ML, Raetz EA, Hunger SP, Pounds SB, Mullighan CG, Frank D, Yang JJ, Bernt KM, Teachey DT, Tan K. Chen C, et al. Blood. 2025 Jun 5;145(23):2685-2700. doi: 10.1182/blood.2024027270. Blood. 2025. PMID: 40089994 Free PMC article.

4

Treatment of focal anaplastic Wilms tumor: A report from the Children's Oncology Group AREN0321 and AREN03B2 studies.

Armstrong AE, Daw NC, Renfro LA, Geller JI, Kalapurakal JA, Khanna G, Paulino AC, Perlman EJ, Ehrlich PF, Gow KW, Warwick AB, Grundy PE, Fernandez CV, Mullen EA, Dome JS; Children's Oncology Group AREN0321 and AREN03B2 Study Committees. Armstrong AE, et al. Cancer. 2025 Jan 15;131(2):e35713. doi: 10.1002/cncr.35713. Cancer. 2025. PMID: 39803937

5

Reply to: Accurate Determinants of Outcome in ALL.

Chang TC, Chen W, Qu C, Cheng Z, Elsayed A, Pounds SB, Shago M, Rabin KR, Raetz EA, Devidas M, Cheng C, Angiolillo A, Baviskar P, Borowitz M, Burke MJ, Carroll A, Carroll WL, Chen IM, Harvey R, Heerema N, Iacobucci I, Wang JR, Jeha S, Larsen E, Mattano L, Maloney K, Pui CH, Ramirez NC, Salzer W, Willman C, Winick N, Wood B, Hunger SP, Wu G, Mullighan CG, Loh ML. Chang TC, et al. J Clin Oncol. 2025 Mar 10;43(8):1039-1041. doi: 10.1200/JCO-24-02335. Epub 2024 Dec 23. J Clin Oncol. 2025. PMID: 39715469 No abstract available.

6

Rhabdoid Tumor of the Kidney and Soft Tissues: Results from National Wilms Tumor Study-5 and Children's Oncology Group Study AREN0321.

Geller JI, Renfro LA, Grundy PE, Perlman EJ, Kalapurakal JA, Ehrlich PF, Biegel J, Huff V, Warwick AB, Paulino A, Mullen EA, Daw NC, Hoffer FA, Tochner Z, Gow K, Gratias E, Ward DA, Anderson JR, Fernandez CV, Dome JS. Geller JI, et al. Pediatr Blood Cancer. 2025 Mar;72(3):e31490. doi: 10.1002/pbc.31490. Epub 2024 Dec 19. Pediatr Blood Cancer. 2025. PMID: 39702900

7

Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia.

Mullighan C, Wangondu R, Ashcraft E, Chang TC, Roberts K, Brady S, Fan Y, Evans W, Relling M, Crews K, Yang J, Yang W, Pounds S, Wu G, Devidas M, Maloney K, Mattano L Jr, Schore R, Angiolillo A, Larsen E, Salzer W, Burke M, Loh M, Jeha S, Pui CH, Inaba H, Cheng C. Mullighan C, et al. Res Sq [Preprint]. 2024 Nov 11:rs.3.rs-5292018. doi: 10.21203/rs.3.rs-5292018/v1. Res Sq. 2024. Update in: Leukemia. 2025 May 13. doi: 10.1038/s41375-025-02633-3. PMID: 39606455 Free PMC article. Updated. Preprint.

8

A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia.

Xu J, Chen C, Sussman JH, Yoshimura S, Vincent T, Pölönen P, Hu J, Bandyopadhyay S, Elghawy O, Yu W, Tumulty J, Chen CH, Li EY, Diorio C, Shraim R, Newman H, Uppuluri L, Li A, Chen GM, Wu DW, Ding YY, Xu JA, Karanfilovski D, Lim T, Hsu M, Thadi A, Ahn KJ, Wu CY, Peng J, Sun Y, Wang A, Mehta R, Frank D, Meyer L, Loh ML, Raetz EA, Chen Z, Wood BL, Devidas M, Dunsmore KP, Winter SS, Chang TC, Wu G, Pounds SB, Zhang NR, Carroll W, Hunger SP, Bernt K, Yang JJ, Mullighan CG, Tan K, Teachey DT. Xu J, et al. Nat Cancer. 2025 Jan;6(1):102-122. doi: 10.1038/s43018-024-00863-5. Epub 2024 Nov 25. Nat Cancer. 2025. PMID: 39587259 Free PMC article.

9

Antileukemia efficacy of the dual BCL2/BCL-XL inhibitor AZD0466 in acute lymphoblastic leukemia preclinical models.

Kannan S, Li Y, Baran N, Yang X, Ghotbaldini S, Zhang Tatarata Q, Yoshimura S, Li Z, Hsiao Y, Balachander S, Andersen CL, Cidado J, Yu J, Jain N, Yang JJ, Konopleva M. Kannan S, et al. Blood Adv. 2025 Feb 11;9(3):473-487. doi: 10.1182/bloodadvances.2024013423. Blood Adv. 2025. PMID: 39561378 Free PMC article.

10

Determinants of survival after first relapse of acute lymphoblastic leukemia: a Children's Oncology Group study.

Rheingold SR, Bhojwani D, Ji L, Xu X, Devidas M, Kairalla JA, Shago M, Heerema NA, Carroll AJ, Breidenbach H, Borowitz M, Wood BL, Angiolillo AL, Asselin BL, Bowman WP, Brown P, Dreyer ZE, Dunsmore KP, Hilden JM, Larsen E, Maloney K, Matloub Y, Mattano LA, Winter SS, Gore L, Winick NJ, Carroll WL, Hunger SP, Raetz EA, Loh ML. Rheingold SR, et al. Leukemia. 2024 Nov;38(11):2382-2394. doi: 10.1038/s41375-024-02395-4. Epub 2024 Sep 11. Leukemia. 2024. PMID: 39261601 Free PMC article.

11

Impact of Genetic Ancestry on T-cell Acute Lymphoblastic Leukemia Outcomes.

Teachey D, Newman H, Lee S, Pölönen P, Shraim R, Li Y, Liu H, Aplenc R, Bandyopadhyay S, Chen C, Chen Z, Devidas M, Diorio C, Dunsmore K, Elghawy O, Elhachimi A, Fuller T, Gupta S, Hall J, Hughes A, Hunger S, Loh M, Martinez Z, McCoy M, Mullen C, Pounds S, Raetz E, Ryan T, Seffernick A, Shi G, Sussman J, Tan K, Uppuluri L, Vincent TL, Wang'ondu R, Winestone L, Winter S, Wood B, Wu G, Xu J, Yang W, Mullighan C, Yang J, Bona K. Teachey D, et al. Res Sq [Preprint]. 2024 Aug 16:rs.3.rs-4858231. doi: 10.21203/rs.3.rs-4858231/v1. Res Sq. 2024. Update in: Blood Cancer Discov. 2025 May 28. doi: 10.1158/2643-3230.BCD-25-0049. PMID: 39184069 Free PMC article. Updated. Preprint.

12

The genomic basis of childhood T-lineage acute lymphoblastic leukaemia.

Pölönen P, Di Giacomo D, Seffernick AE, Elsayed A, Kimura S, Benini F, Montefiori LE, Wood BL, Xu J, Chen C, Cheng Z, Newman H, Myers J, Iacobucci I, Li E, Sussman J, Hedges D, Hui Y, Diorio C, Uppuluri L, Frank D, Fan Y, Chang Y, Meshinchi S, Ries R, Shraim R, Li A, Bernt KM, Devidas M, Winter SS, Dunsmore KP, Inaba H, Carroll WL, Ramirez NC, Phillips AH, Kriwacki RW, Yang JJ, Vincent TL, Zhao Y, Ghate PS, Wang J, Reilly C, Zhou X, Sanders MA, Takita J, Kato M, Takasugi N, Chang BH, Press RD, Loh M, Rampersaud E, Raetz E, Hunger SP, Tan K, Chang TC, Wu G, Pounds SB, Mullighan CG, Teachey DT. Pölönen P, et al. Nature. 2024 Aug;632(8027):1082-1091. doi: 10.1038/s41586-024-07807-0. Epub 2024 Aug 14. Nature. 2024. PMID: 39143224 Free PMC article.

13

Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia.

Chang TC, Chen W, Qu C, Cheng Z, Hedges D, Elsayed A, Pounds SB, Shago M, Rabin KR, Raetz EA, Devidas M, Cheng C, Angiolillo A, Baviskar P, Borowitz M, Burke MJ, Carroll A, Carroll WL, Chen IM, Harvey R, Heerema N, Iacobucci I, Wang JR, Jeha S, Larsen E, Mattano L, Maloney K, Pui CH, Ramirez NC, Salzer W, Willman C, Winick N, Wood B, Hunger SP, Wu G, Mullighan CG, Loh ML. Chang TC, et al. J Clin Oncol. 2024 Oct 10;42(29):3491-3503. doi: 10.1200/JCO.23.02238. Epub 2024 Aug 9. J Clin Oncol. 2024. PMID: 39121442 Free PMC article.

14

Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk.

Kimura S, Park CS, Montefiori LE, Iacobucci I, Pölönen P, Gao Q, Arnold ED, Attarbaschi A, Brown A, Buldini B, Caldwell KJ, Chang Y, Chen C, Cheng C, Cheng Z, Choi J, Conter V, Crews KR, de Groot-Kruseman HA, Deguchi T, Eguchi M, Muhle HE, Elitzur S, Escherich G, Freeman BB 3rd, Gu Z, Han K, Horibe K, Imamura T, Jeha S, Kato M, Chiew KH, Khan T, Kicinski M, Köhrer S, Kornblau SM, Kotecha RS, Li CK, Liu YC, Locatelli F, Luger SM, Paietta EM, Manabe A, Marquart HV, Masetti R, Maybury M, Mazilier P, Meijerink JPP, Mitchell S, Miyamura T, Moore AS, Oshima K, Pawinska-Wasikowska K, Pieters R, Prater MS, Pruett-Miller SM, Pui CH, Qu C, Reiterova M, Reyes N, Roberts KG, Rowe JM, Sato A, Schmiegelow K, Schrappe M, Shen S, Skoczeń S, Spinelli O, Stary J, Svaton M, Takagi M, Takita J, Tang Y, Teachey DT, Thomas PG, Tomizawa D, Trka J, Varotto E, Vincent TL, Yang JJ, Yeoh AEJ, Zhou Y, Zimmermann M, Inaba H, Mullighan CG. Kimura S, et al. Cancer Discov. 2024 Oct 4;14(10):1838-1859. doi: 10.1158/2159-8290.CD-23-1452. Cancer Discov. 2024. PMID: 38916500 Free PMC article.

15

Bilateral Wilms tumor with anaplasia: A report from the Children's Oncology Group Study AREN0534.

Romao RLP, Aldrink JH, Renfro LA, Mullen EA, Murphy AJ, Brzezinski J, Malek MM, Benedetti DJ, Cost NG, Smith E, Dome JS, Davidoff AM, Treece A, Parsons LN, Fernandez CV, Tornwall B, Shamberger RC, Paulino A, Kalapurakal JA, Geller JI, Ehrlich PF. Romao RLP, et al. Pediatr Blood Cancer. 2024 Jul;71(7):e30981. doi: 10.1002/pbc.30981. Epub 2024 Apr 18. Pediatr Blood Cancer. 2024. PMID: 38637871

16

Germline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma: A Report From the Children's Oncology Group.

Martin-Giacalone BA, Li H, Scheurer ME, Casey DL, Dugan-Perez S, Marquez-Do DA, Muzny D, Gibbs RA, Barkauskas DA, Hall D, Stewart DR, Schiffman JD, McEvoy MT, Khan J, Malkin D, Linardic CM, Crompton BD, Shern JF, Skapek SX, Venkatramani R, Hawkins DS, Sabo A, Plon SE, Lupo PJ. Martin-Giacalone BA, et al. JAMA Netw Open. 2024 Mar 4;7(3):e244170. doi: 10.1001/jamanetworkopen.2024.4170. JAMA Netw Open. 2024. PMID: 38546643 Free PMC article.

17

Treatment and outcomes of clear cell sarcoma of the kidney: A report from the Children's Oncology Group studies AREN0321 and AREN03B2.

Benedetti DJ, Renfro LA, Tfirn I, Daw NC, Kalapurakal JA, Ehrlich PF, Khanna G, Perlman E, Warwick A, Gow KW, Paulino AC, Seibel NL, Grundy P, Fernandez CV, Geller JI, Mullen EA, Dome JS. Benedetti DJ, et al. Cancer. 2024 Jul 1;130(13):2361-2371. doi: 10.1002/cncr.35266. Epub 2024 Feb 23. Cancer. 2024. PMID: 38396300

18

Enhanced Risk Stratification for Children and Young Adults with B-Cell Acute Lymphoblastic Leukemia: A Children's Oncology Group Report.

DelRocco NJ, Loh ML, Borowitz MJ, Gupta S, Rabin KR, Zweidler-McKay P, Maloney KW, Mattano LA, Larsen E, Angiolillo A, Schore RJ, Burke MJ, Salzer WL, Wood BL, Carroll AJ, Heerema NA, Reshmi SC, Gastier-Foster JM, Harvey R, Chen IM, Roberts KG, Mullighan CG, Willman C, Winick N, Carroll WL, Rau RE, Teachey DT, Hunger SP, Raetz EA, Devidas M, Kairalla JA. DelRocco NJ, et al. Leukemia. 2024 Apr;38(4):720-728. doi: 10.1038/s41375-024-02166-1. Epub 2024 Feb 15. Leukemia. 2024. PMID: 38360863 Free PMC article.

19

RNA helicase DDX3 regulates RAD51 localization and DNA damage repair in Ewing sarcoma.

Randolph ME, Afifi M, Gorthi A, Weil R, Wilky BA, Weinreb J, Ciero P, Hoeve NT, van Diest PJ, Raman V, Bishop AJR, Loeb DM. Randolph ME, et al. iScience. 2024 Jan 16;27(2):108925. doi: 10.1016/j.isci.2024.108925. eCollection 2024 Feb 16. iScience. 2024. PMID: 38323009 Free PMC article.

20

Race and Ethnic Group Enrollment and Outcomes for Wilms Tumor: Analysis of the Current Era Children's Oncology Group Study, AREN03B2.

Lovvorn HN 3rd, Renfro LA, Benedetti DJ, Kotagal M, Phelps HM, Ehrlich PF, Lo AC, Sandberg JK, Treece AL, Gow KW, Glick RD, Davidoff AM, Cost NG, Dix DB, Fernandez CV, Dome JS, Geller JI, Mullen EA. Lovvorn HN 3rd, et al. J Am Coll Surg. 2024 Apr 1;238(4):733-749. doi: 10.1097/XCS.0000000000000999. Epub 2024 Mar 15. J Am Coll Surg. 2024. PMID: 38251681 Free PMC article.

21

BRAF Exon 15 Mutations in the Evaluation of Well-Differentiated Epithelial Nephroblastic Neoplasms in Children: A Report From the Children's Oncology Group Study AREN03B2.

Goldstein JA, Renfro LA, Jennings LJ, Mullen EA, Geller J, Vallance K, Fernandez CV, Perlman EJ. Goldstein JA, et al. Arch Pathol Lab Med. 2024 Oct 1;148(10):e362-e366. doi: 10.5858/arpa.2022-0528-OA. Arch Pathol Lab Med. 2024. PMID: 38116848 Free PMC article.

22

Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children's Oncology Group AREN18B5-Q.

Murphy AJ, Cheng C, Williams J, Shaw TI, Pinto EM, Dieseldorff-Jones K, Brzezinski J, Renfro LA, Tornwall B, Huff V, Hong AL, Mullen EA, Crompton B, Dome JS, Fernandez CV, Geller JI, Ehrlich PF, Mulder H, Oak N, Maciezsek J, Jablonowski CM, Fleming AM, Pichavaram P, Morton CL, Easton J, Nichols KE, Clay MR, Santiago T, Zhang J, Yang J, Zambetti GP, Wang Z, Davidoff AM, Chen X. Murphy AJ, et al. Nat Commun. 2023 Dec 18;14(1):8006. doi: 10.1038/s41467-023-43730-0. Nat Commun. 2023. PMID: 38110397 Free PMC article.

23

Treatment of children with favorable histology Wilms tumor with extrapulmonary metastases: A report from the COG studies AREN0533 and AREN03B2 and NWTSG study NWTS-5.

Benedetti DJ, Varela CR, Renfro LA, Tornwall B, Dix DB, Ehrlich PF, Glick RD, Kalapurakal J, Perlman E, Gratias E, Seibel NL, Geller JI, Khanna G, Malogolowkin M, Grundy P, Fernandez CV, Dome JS, Mullen EA. Benedetti DJ, et al. Cancer. 2024 Mar 15;130(6):947-961. doi: 10.1002/cncr.35099. Epub 2023 Nov 7. Cancer. 2024. PMID: 37933882 Free PMC article. Clinical Trial.

24

Prognostic impact of lymph node involvement and loss of heterozygosity of 1p or 16q in stage III favorable histology Wilms tumor: A report from Children's Oncology Group Studies AREN03B2 and AREN0532.

Evageliou N, Renfro LA, Geller J, Perlman E, Kalapurakal J, Paulino A, Dix D, Eklund MJ, Murphy AJ, Romao RLP, Ehrlich PF, Varela CR, Vallance K, Fernandez CV, Dome JS, Mullen EA. Evageliou N, et al. Cancer. 2024 Mar 1;130(5):792-802. doi: 10.1002/cncr.35084. Epub 2023 Oct 30. Cancer. 2024. PMID: 37902955 Free PMC article.

25

Outcomes in Children, Adolescents, and Young Adults With Down Syndrome and ALL: A Report From the Children's Oncology Group.

Rabin KR, Devidas M, Chen Z, Ji L, Kairalla J, Hitzler JK, Yang JJ, Carroll AJ, Heerema NA, Borowitz MJ, Wood BL, Roberts KG, Mullighan CG, Harvey RC, Chen IM, Willman CL, Reshmi SC, Gastier-Foster JM, Bhojwani D, Rheingold SR, Maloney KW, Mattano LA, Larsen EC, Schore RJ, Burke MJ, Salzer WL, Winick NJ, Carroll WL, Raetz EA, Loh ML, Hunger SP, Angiolillo AL. Rabin KR, et al. J Clin Oncol. 2024 Jan 10;42(2):218-227. doi: 10.1200/JCO.23.00389. Epub 2023 Oct 27. J Clin Oncol. 2024. PMID: 37890117 Free PMC article.

26

Prognostic significance of ETP phenotype and minimal residual disease in T-ALL: a Children's Oncology Group study.

Wood BL, Devidas M, Summers RJ, Chen Z, Asselin B, Rabin KR, Zweidler-McKay PA, Winick NJ, Borowitz MJ, Carroll WL, Raetz EA, Loh ML, Hunger SP, Dunsmore KP, Teachey DT, Winter SS. Wood BL, et al. Blood. 2023 Dec 14;142(24):2069-2078. doi: 10.1182/blood.2023020678. Blood. 2023. PMID: 37556734 Free PMC article. Clinical Trial.

27

Children's Oncology Group's 2023 blueprint for research: Central nervous system tumors.

Leary SES, Onar-Thomas A, Fangusaro J, Gottardo NG, Cohen K, Smith A, Huang A, Haas-Kogan D, Fouladi M; COG Central Nervous System Committee. Leary SES, et al. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30600. doi: 10.1002/pbc.30600. Epub 2023 Aug 3. Pediatr Blood Cancer. 2023. PMID: 37534382 Free PMC article.

28

Children's Oncology Group's 2023 blueprint for research: Bone tumors.

Reed DR, Grohar P, Rubin E, Binitie O, Krailo M, Davis J, DuBois SG, Janeway KA. Reed DR, et al. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30583. doi: 10.1002/pbc.30583. Epub 2023 Jul 27. Pediatr Blood Cancer. 2023. PMID: 37501549 Free PMC article.

29

Children's Oncology Group's 2023 blueprint for research: Liver tumors.

O'Neill AF, Meyers RL, Katzenstein HM, Geller JI, Tiao GM, López-Terrada D, Malogolowkin M; Liver Tumor Committee. O'Neill AF, et al. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30576. doi: 10.1002/pbc.30576. Epub 2023 Jul 26. Pediatr Blood Cancer. 2023. PMID: 37495540 Free PMC article.

30

Children's Oncology Group's 2023 blueprint for research: Renal tumors.

Geller JI, Hong AL, Vallance KL, Evageliou N, Aldrink JH, Cost NG, Treece AL, Renfro LA, Mullen EA; COG Renal Tumor Committee. Geller JI, et al. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30586. doi: 10.1002/pbc.30586. Epub 2023 Jul 21. Pediatr Blood Cancer. 2023. PMID: 37477907 Free PMC article.

31

Children's Oncology Group's 2023 blueprint for research: Germ cell tumors.

Bhuta R, Shah R, Gell JJ, Poynter JN, Bagrodia A, Dicken BJ, Pashankar F, Frazier AL, Shaikh F. Bhuta R, et al. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30562. doi: 10.1002/pbc.30562. Epub 2023 Jul 14. Pediatr Blood Cancer. 2023. PMID: 37449938 Free PMC article.

32

Children's Oncology Group's 2023 blueprint for research.

Hawkins DS, Gore L. Hawkins DS, et al. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30569. doi: 10.1002/pbc.30569. Epub 2023 Jul 11. Pediatr Blood Cancer. 2023. PMID: 37433635 Free PMC article. No abstract available.

33

Children's Oncology Group's 2023 blueprint for research: Developmental therapeutics.

Fox E, Parsons DW, Weigel BJ; Developmental Therapeutics Committee. Fox E, et al. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30563. doi: 10.1002/pbc.30563. Epub 2023 Jul 10. Pediatr Blood Cancer. 2023. PMID: 37430453 Free PMC article.

34

Children's Oncology Group's 2023 blueprint for research: Soft tissue sarcomas.

Oberoi S, Crane JN, Haduong JH, Rudzinski ER, Wolden SL, Dasgupta R, Linardic CM, Weiss AR, Venkatramani R; the Children's Oncology Group Soft Tissue Sarcoma Committee. Oberoi S, et al. Pediatr Blood Cancer. 2023 Sep;70 Suppl 6(Suppl 6):e30556. doi: 10.1002/pbc.30556. Epub 2023 Jul 10. Pediatr Blood Cancer. 2023. PMID: 37430436 Free PMC article.

35

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma.

Randolph ME, Afifi M, Gorthi A, Weil R, Wilky BA, Weinreb J, Ciero P, Ter Hoeve N, van Diest PJ, Raman V, Bishop AJR, Loeb DM. Randolph ME, et al. bioRxiv [Preprint]. 2023 Jun 10:2023.06.10.544474. doi: 10.1101/2023.06.10.544474. bioRxiv. 2023. Update in: iScience. 2024 Jan 16;27(2):108925. doi: 10.1016/j.isci.2024.108925. PMID: 37333164 Free PMC article. Updated. Preprint.

36

Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence.

Xu L, Pierce JL, Sanchez A, Chen KS, Shukla AA, Fustino NJ, Stuart SH, Bagrodia A, Xiao X, Guo L, Krailo MD, Shaikh F, Billmire DF, Pashankar F, Bestrashniy J, Oosterhuis JW, Gillis AJM, Xie Y, Teot L, Mora J, Poynter JN, Rakheja D, Looijenga LHJ, Draper BW, Frazier AL, Amatruda JF. Xu L, et al. Nat Commun. 2023 May 6;14(1):2636. doi: 10.1038/s41467-023-38378-9. Nat Commun. 2023. PMID: 37149691 Free PMC article.

37

Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia.

Li Z, Chang TC, Junco JJ, Devidas M, Li Y, Yang W, Huang X, Hedges DJ, Cheng Z, Shago M, Carroll AJ, Heerema NA, Gastier-Foster J, Wood BL, Borowitz MJ, Sanclemente L, Raetz EA, Hunger SP, Feingold E, Rosser TC, Sherman SL, Loh ML, Mullighan CG, Yu J, Wu G, Lupo PJ, Rabin KR, Yang JJ. Li Z, et al. Blood. 2023 Jul 13;142(2):172-184. doi: 10.1182/blood.2023019765. Blood. 2023. PMID: 37001051 Free PMC article.

38

Outstanding outcomes with two low intensity regimens in children with low-risk B-ALL: a report from COG AALL0932.

Schore RJ, Angiolillo AL, Kairalla JA, Devidas M, Rabin KR, Zweidler-McKay P, Borowitz MJ, Wood B, Carroll AJ, Heerema NA, Relling MV, Hitzler J, Kadan-Lottick NS, Maloney K, Wang C, Carroll WL, Winick NJ, Raetz EA, Loh ML, Hunger SP. Schore RJ, et al. Leukemia. 2023 Jun;37(6):1375-1378. doi: 10.1038/s41375-023-01870-8. Epub 2023 Mar 25. Leukemia. 2023. PMID: 36966262 Free PMC article. No abstract available.

39

KMT2A partner genes in infant acute lymphoblastic leukemia have prognostic significance and correlate with age, white blood cell count, sex, and central nervous system involvement: a Children's Oncology Group P9407 trial study.

Robinson BW, Kairalla JA, Devidas M, Carroll AJ, Harvey RC, Heerema NA, Willman CL, Ball AR, Woods EC, Ballantyne NC, Urtishak KA, Behm FG, Reaman GH, Hilden JM, Camitta BM, Winick NJ, Pullen J, Carroll WL, Hunger SP, Dreyer ZE, Felix CA. Robinson BW, et al. Haematologica. 2023 Oct 1;108(10):2865-2871. doi: 10.3324/haematol.2022.281552. Haematologica. 2023. PMID: 36861410 Free PMC article. No abstract available.

40

Circulating Tumor DNA Is Prognostic in Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.

Abbou S, Klega K, Tsuji J, Tanhaemami M, Hall D, Barkauskas DA, Krailo MD, Cibulskis C, Nag A, Thorner AR, Pollock S, Imamovic-Tuco A, Shern JF, DuBois SG, Venkatramani R, Hawkins DS, Crompton BD. Abbou S, et al. J Clin Oncol. 2023 May 1;41(13):2382-2393. doi: 10.1200/JCO.22.00409. Epub 2023 Feb 1. J Clin Oncol. 2023. PMID: 36724417 Free PMC article.

41

Adverse prognostic impact of the loss of STAG2 protein expression in patients with newly diagnosed localised Ewing sarcoma: A report from the Children's Oncology Group.

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Genome-Wide Approach to Measure Variant-Based Heritability of Drug Outcome Phenotypes.

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The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment.

Tran TH, Nguyen JV, Stecula A, Akutagawa J, Moorman AV, Braun BS, Sali A, Mullighan CG, Shah NP, Dai Y, Devidas M, Roberts KG, Smith CC, Loh ML. Tran TH, et al. Haematologica. 2021 Aug 1;106(8):2242-2245. doi: 10.3324/haematol.2020.261354. Haematologica. 2021. PMID: 33626861 Free PMC article. No abstract available.

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RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia.

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Excellent Outcomes With Reduced Frequency of Vincristine and Dexamethasone Pulses in Standard-Risk B-Lymphoblastic Leukemia: Results From Children's Oncology Group AALL0932.

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New approaches to risk stratification for Wilms tumor.

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Outcomes of paediatric patients with B-cell acute lymphocytic leukaemia with ABL-class fusion in the pre-tyrosine-kinase inhibitor era: a multicentre, retrospective, cohort study.

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Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children's Oncology Group.

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Molecular basis of ETV6-mediated predisposition to childhood acute lymphoblastic leukemia.

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Risk-associated alterations in marrow T cells in pediatric leukemia.

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Leveraging Genome and Phenome-Wide Association Studies to Investigate Genetic Risk of Acute Lymphoblastic Leukemia.

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Results of Treatment for Patients With Multicentric or Bilaterally Predisposed Unilateral Wilms Tumor (AREN0534): A report from the Children's Oncology Group.

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Outcome analysis of stage I epithelial-predominant favorable-histology Wilms tumors: A report from Children's Oncology Group study AREN03B2.

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Imaging Characteristics of Nephrogenic Rests Versus Small Wilms Tumors: A Report From the Children's Oncology Group Study AREN03B2.

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Activity of Vincristine and Irinotecan in Diffuse Anaplastic Wilms Tumor and Therapy Outcomes of Stage II to IV Disease: Results of the Children's Oncology Group AREN0321 Study.

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A practical framework and online tool for mutational signature analyses show inter-tissue variation and driver dependencies.

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Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation.

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Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk.

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Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia.

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Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.

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The ganglioside G_D2 as a circulating tumor biomarker for neuroblastoma.

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Augmentation of Therapy for Combined Loss of Heterozygosity 1p and 16q in Favorable Histology Wilms Tumor: A Children's Oncology Group AREN0532 and AREN0533 Study Report.

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Treatment of stage I anaplastic Wilms' tumour: a report from the Children's Oncology Group AREN0321 study.

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IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children's Oncology Group trials.

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Epigenetic silencing of SOCS5 potentiates JAK-STAT signaling and progression of T-cell acute lymphoblastic leukemia.

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No evidence that G6PD deficiency affects the efficacy or safety of daunorubicin in acute lymphoblastic leukemia induction therapy.

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Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia.

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Characterization of leukemias with ETV6-ABL1 fusion.

Zaliova M, Moorman AV, Cazzaniga G, Stanulla M, Harvey RC, Roberts KG, Heatley SL, Loh ML, Konopleva M, Chen IM, Zimmermannova O, Schwab C, Smith O, Mozziconacci MJ, Chabannon C, Kim M, Frederik Falkenburg JH, Norton A, Marshall K, Haas OA, Starkova J, Stuchly J, Hunger SP, White D, Mullighan CG, Willman CL, Stary J, Trka J, Zuna J. Zaliova M, et al. Haematologica. 2016 Sep;101(9):1082-93. doi: 10.3324/haematol.2016.144345. Epub 2016 May 26. Haematologica. 2016. PMID: 27229714 Free PMC article.

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Expanding the spectrum of ALK-rearranged renal cell carcinomas in children: Identification of a novel HOOK1-ALK fusion transcript.

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A Novel EGFR Extracellular Domain Mutant, EGFRΔ768, Possesses Distinct Biological and Biochemical Properties in Neuroblastoma.

Keller J, Nimnual AS, Varghese MS, VanHeyst KA, Hayman MJ, Chan EL. Keller J, et al. Mol Cancer Res. 2016 Aug;14(8):740-52. doi: 10.1158/1541-7786.MCR-15-0477. Epub 2016 May 23. Mol Cancer Res. 2016. PMID: 27216155 Free PMC article.

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Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.

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p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma.

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Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

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A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution.

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Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. Temple W, et al. Eur J Nucl Med Mol Imaging. 2016 Mar;43(3):474-481. doi: 10.1007/s00259-015-3179-2. Epub 2015 Sep 4. Eur J Nucl Med Mol Imaging. 2016. PMID: 26338179 Free PMC article.

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A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma.

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Gene Expression Profiling of Ewing Sarcoma Tumors Reveals the Prognostic Importance of Tumor-Stromal Interactions: A Report from the Children's Oncology Group.

Volchenboum SL, Andrade J, Huang L, Barkauskas DA, Krailo M, Womer RB, Ranft A, Potratz J, Dirksen U, Triche TJ, Lawlor ER. Volchenboum SL, et al. J Pathol Clin Res. 2015 Apr;1(2):83-94. doi: 10.1002/cjp2.9. J Pathol Clin Res. 2015. PMID: 26052443 Free PMC article.

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Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.

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Characterization of adolescent and pediatric renal cell carcinoma: A report from the Children's Oncology Group study AREN03B2.

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A phase 2 study of bortezomib in combination with ifosfamide/vinorelbine in paediatric patients and young adults with refractory/recurrent Hodgkin lymphoma: a Children's Oncology Group study.

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Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia.

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Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.

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A summary of the osteosarcoma banking efforts: a report from the Children's Oncology Group and the QuadW Foundation.

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Evaluation of the in vitro and in vivo efficacy of the JAK inhibitor AZD1480 against JAK-mutated acute lymphoblastic leukemia.

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A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults.

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Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

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Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.

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174

Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.

Chonghaile TN, Roderick JE, Glenfield C, Ryan J, Sallan SE, Silverman LB, Loh ML, Hunger SP, Wood B, DeAngelo DJ, Stone R, Harris M, Gutierrez A, Kelliher MA, Letai A. Chonghaile TN, et al. Cancer Discov. 2014 Sep;4(9):1074-87. doi: 10.1158/2159-8290.CD-14-0353. Epub 2014 Jul 3. Cancer Discov. 2014. PMID: 24994123 Free PMC article.

175

HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.

Fernandez CA, Smith C, Yang W, Daté M, Bashford D, Larsen E, Bowman WP, Liu C, Ramsey LB, Chang T, Turner V, Loh ML, Raetz EA, Winick NJ, Hunger SP, Carroll WL, Onengut-Gumuscu S, Chen WM, Concannon P, Rich SS, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Relling MV. Fernandez CA, et al. Blood. 2014 Aug 21;124(8):1266-76. doi: 10.1182/blood-2014-03-563742. Epub 2014 Jun 26. Blood. 2014. PMID: 24970932 Free PMC article. Clinical Trial.

176

Detection of minimal residual disease in B lymphoblastic leukemia by high-throughput sequencing of IGH.

Wu D, Emerson RO, Sherwood A, Loh ML, Angiolillo A, Howie B, Vogt J, Rieder M, Kirsch I, Carlson C, Williamson D, Wood BL, Robins H. Wu D, et al. Clin Cancer Res. 2014 Sep 1;20(17):4540-8. doi: 10.1158/1078-0432.CCR-13-3231. Epub 2014 Jun 26. Clin Cancer Res. 2014. PMID: 24970842 Free PMC article.

177

Toward a drug development path that targets metastatic progression in osteosarcoma.

Khanna C, Fan TM, Gorlick R, Helman LJ, Kleinerman ES, Adamson PC, Houghton PJ, Tap WD, Welch DR, Steeg PS, Merlino G, Sorensen PH, Meltzer P, Kirsch DG, Janeway KA, Weigel B, Randall L, Withrow SJ, Paoloni M, Kaplan R, Teicher BA, Seibel NL, Smith M, Uren A, Patel SR, Trent J, Savage SA, Mirabello L, Reinke D, Barkaukas DA, Krailo M, Bernstein M. Khanna C, et al. Clin Cancer Res. 2014 Aug 15;20(16):4200-9. doi: 10.1158/1078-0432.CCR-13-2574. Epub 2014 May 6. Clin Cancer Res. 2014. PMID: 24803583 Free PMC article.

178

HER-2 expression is not prognostic in osteosarcoma; a Children's Oncology Group prospective biology study.

Gorlick S, Barkauskas DA, Krailo M, Piperdi S, Sowers R, Gill J, Geller D, Randall RL, Janeway K, Schwartz C, Grier H, Meyers PA, Gorlick R, Bernstein M, Marina N. Gorlick S, et al. Pediatr Blood Cancer. 2014 Sep;61(9):1558-64. doi: 10.1002/pbc.25074. Epub 2014 Apr 22. Pediatr Blood Cancer. 2014. PMID: 24753182 Free PMC article.

179

Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group.

Tarlock K, Alonzo TA, Moraleda PP, Gerbing RB, Raimondi SC, Hirsch BA, Ravindranath Y, Lange B, Woods WG, Gamis AS, Meshinchi S. Tarlock K, et al. Br J Haematol. 2014 Jul;166(2):254-259. doi: 10.1111/bjh.12852. Epub 2014 Mar 25. Br J Haematol. 2014. PMID: 24661089 Free PMC article. Clinical Trial.

180

High expression of suppressor of cytokine signaling-2 predicts poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.

Laszlo GS, Ries RE, Gudgeon CJ, Harrington KH, Alonzo TA, Gerbing RB, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB. Laszlo GS, et al. Leuk Lymphoma. 2014 Dec;55(12):2817-21. doi: 10.3109/10428194.2014.893305. Epub 2014 Mar 24. Leuk Lymphoma. 2014. PMID: 24559289 Free PMC article.

181

DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma.

Doros LA, Rossi CT, Yang J, Field A, Williams GM, Messinger Y, Cajaiba MM, Perlman EJ, A Schultz K, Cathro HP, Legallo RD, LaFortune KA, Chikwava KR, Faria P, Geller JI, Dome JS, Mullen EA, Gratias EJ, Dehner LP, Hill DA. Doros LA, et al. Mod Pathol. 2014 Sep;27(9):1267-80. doi: 10.1038/modpathol.2013.242. Epub 2014 Jan 31. Mod Pathol. 2014. PMID: 24481001 Free PMC article.

182

ATP Binding Cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia.

Winter SS, Ricci J, Luo L, Lovato DM, Khawaja HM, Serna-Gallegos T, Debassige N, Larson RS. Winter SS, et al. Health (Irvine Calif). 2013 May;5(5A):41-50. doi: 10.4236/health.2013.55A005. Health (Irvine Calif). 2013. PMID: 24224072 Free PMC article.

183

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group.

Buitenkamp TD, Izraeli S, Zimmermann M, Forestier E, Heerema NA, van den Heuvel-Eibrink MM, Pieters R, Korbijn CM, Silverman LB, Schmiegelow K, Liang DC, Horibe K, Arico M, Biondi A, Basso G, Rabin KR, Schrappe M, Cario G, Mann G, Morak M, Panzer-Grümayer R, Mondelaers V, Lammens T, Cavé H, Stark B, Ganmore I, Moorman AV, Vora A, Hunger SP, Pui CH, Mullighan CG, Manabe A, Escherich G, Kowalczyk JR, Whitlock JA, Zwaan CM. Buitenkamp TD, et al. Blood. 2014 Jan 2;123(1):70-7. doi: 10.1182/blood-2013-06-509463. Epub 2013 Nov 12. Blood. 2014. PMID: 24222333 Free PMC article.

184

Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children's oncology group study.

Borinstein SC, Barkauskas DA, Bernstein M, Goorin A, Gorlick R, Krailo M, Schwartz CL, Wexler LH, Toretsky JA. Borinstein SC, et al. Pediatr Blood Cancer. 2014 Apr;61(4):749-52. doi: 10.1002/pbc.24778. Epub 2013 Oct 31. Pediatr Blood Cancer. 2014. PMID: 24178953 Free PMC article.

185

Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse.

Perez-Andreu V, Roberts KG, Harvey RC, Yang W, Cheng C, Pei D, Xu H, Gastier-Foster J, E S, Lim JY, Chen IM, Fan Y, Devidas M, Borowitz MJ, Smith C, Neale G, Burchard EG, Torgerson DG, Klussmann FA, Villagran CR, Winick NJ, Camitta BM, Raetz E, Wood B, Yue F, Carroll WL, Larsen E, Bowman WP, Loh ML, Dean M, Bhojwani D, Pui CH, Evans WE, Relling MV, Hunger SP, Willman CL, Mullighan CG, Yang JJ. Perez-Andreu V, et al. Nat Genet. 2013 Dec;45(12):1494-8. doi: 10.1038/ng.2803. Epub 2013 Oct 20. Nat Genet. 2013. PMID: 24141364 Free PMC article.

186

BIRC5 (survivin) splice variant expression correlates with refractory disease and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.

Moore AS, Alonzo TA, Gerbing RB, Lange BJ, Heerema NA, Franklin J, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S. Moore AS, et al. Pediatr Blood Cancer. 2014 Apr;61(4):647-52. doi: 10.1002/pbc.24822. Epub 2013 Oct 11. Pediatr Blood Cancer. 2014. PMID: 24127439 Free PMC article.

187

Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements.

De Lorenzo P, Moorman AV, Pieters R, Dreyer ZE, Heerema NA, Carroll AJ, Hunger SP, Harvey R, Willman CL, Devidas M, Valsecchi MG, Harrison CJ. De Lorenzo P, et al. Leukemia. 2014 Feb;28(2):428-30. doi: 10.1038/leu.2013.280. Epub 2013 Sep 27. Leukemia. 2014. PMID: 24072099 Free PMC article. No abstract available.

188

Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma.

Jacob AG, O'Brien D, Singh RK, Comiskey DF Jr, Littleton RM, Mohammad F, Gladman JT, Widmann MC, Jeyaraj SC, Bolinger C, Anderson JR, Barkauskas DA, Boris-Lawrie K, Chandler DS. Jacob AG, et al. Neoplasia. 2013 Sep;15(9):1049-63. doi: 10.1593/neo.13286. Neoplasia. 2013. PMID: 24027430 Free PMC article.

189

High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: a report from the Children's Oncology Group.

Altaf S, Enders F, Jeavons E, Krailo M, Barkauskas DA, Meyers P, Arndt C. Altaf S, et al. Pediatr Blood Cancer. 2013 Dec;60(12):2042-6. doi: 10.1002/pbc.24580. Epub 2013 Aug 17. Pediatr Blood Cancer. 2013. PMID: 23955975 Clinical Trial.

190

Intrachromosomal amplification of chromosome 21 is associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary standard-risk children's oncology group studies: a report from the children's oncology group.

Heerema NA, Carroll AJ, Devidas M, Loh ML, Borowitz MJ, Gastier-Foster JM, Larsen EC, Mattano LA Jr, Maloney KW, Willman CL, Wood BL, Winick NJ, Carroll WL, Hunger SP, Raetz EA. Heerema NA, et al. J Clin Oncol. 2013 Sep 20;31(27):3397-402. doi: 10.1200/JCO.2013.49.1308. Epub 2013 Aug 12. J Clin Oncol. 2013. PMID: 23940221 Free PMC article. Clinical Trial.

191

VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.

Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Müschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD. Mangum DS, et al. Leukemia. 2014 Jan;28(1):216-20. doi: 10.1038/leu.2013.223. Epub 2013 Jul 24. Leukemia. 2014. PMID: 23881307 Free PMC article. No abstract available.

192

Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia.

Linger RM, Lee-Sherick AB, DeRyckere D, Cohen RA, Jacobsen KM, McGranahan A, Brandão LN, Winges A, Sawczyn KK, Liang X, Keating AK, Tan AC, Earp HS, Graham DK. Linger RM, et al. Blood. 2013 Aug 29;122(9):1599-609. doi: 10.1182/blood-2013-01-478156. Epub 2013 Jul 16. Blood. 2013. PMID: 23861246 Free PMC article.

193

Biomarkers in Ewing Sarcoma: The Promise and Challenge of Personalized Medicine. A Report from the Children's Oncology Group.

Shukla N, Schiffman J, Reed D, Davis IJ, Womer RB, Lessnick SL, Lawlor ER; COG Ewing Sarcoma Biology Committee. Shukla N, et al. Front Oncol. 2013 Jun 6;3:141. doi: 10.3389/fonc.2013.00141. eCollection 2013. Front Oncol. 2013. PMID: 23761859 Free PMC article.

194

Genome-wide association study identifies two susceptibility loci for osteosarcoma.

Savage SA, Mirabello L, Wang Z, Gastier-Foster JM, Gorlick R, Khanna C, Flanagan AM, Tirabosco R, Andrulis IL, Wunder JS, Gokgoz N, Patiño-Garcia A, Sierrasesúmaga L, Lecanda F, Kurucu N, Ilhan IE, Sari N, Serra M, Hattinger C, Picci P, Spector LG, Barkauskas DA, Marina N, de Toledo SR, Petrilli AS, Amary MF, Halai D, Thomas DM, Douglass C, Meltzer PS, Jacobs K, Chung CC, Berndt SI, Purdue MP, Caporaso NE, Tucker M, Rothman N, Landi MT, Silverman DT, Kraft P, Hunter DJ, Malats N, Kogevinas M, Wacholder S, Troisi R, Helman L, Fraumeni JF Jr, Yeager M, Hoover RN, Chanock SJ. Savage SA, et al. Nat Genet. 2013 Jul;45(7):799-803. doi: 10.1038/ng.2645. Epub 2013 Jun 2. Nat Genet. 2013. PMID: 23727862 Free PMC article.

195

Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: a report from the Children's Oncology Group.

Walter RB, Laszlo GS, Alonzo TA, Gerbing RB, Levy S, Fitzgibbon MP, Gudgeon CJ, Ries RE, Harrington KH, Raimondi SC, Hirsch BA, Gamis AS, W McIntosh M, Meshinchi S. Walter RB, et al. Am J Hematol. 2013 Aug;88(8):694-702. doi: 10.1002/ajh.23486. Epub 2013 Jun 20. Am J Hematol. 2013. PMID: 23686445 Free PMC article. Clinical Trial.

196

A Decade in Banking Ewing Sarcoma: A Report from the Children's Oncology Group.

Borinstein SC, Beeler N, Block JJ, Gorlick R, Grohar P, Jedlicka P, Krailo M, Morris C, Phillips S, Siegal GP, Lawlor ER, Lessnick SL; COG Ewing Sarcoma Biology Committee. Borinstein SC, et al. Front Oncol. 2013 Mar 20;3:57. doi: 10.3389/fonc.2013.00057. eCollection 2013. Front Oncol. 2013. PMID: 23519678 Free PMC article.

197

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.

Xu H, Yang W, Perez-Andreu V, Devidas M, Fan Y, Cheng C, Pei D, Scheet P, Burchard EG, Eng C, Huntsman S, Torgerson DG, Dean M, Winick NJ, Martin PL, Camitta BM, Bowman WP, Willman CL, Carroll WL, Mullighan CG, Bhojwani D, Hunger SP, Pui CH, Evans WE, Relling MV, Loh ML, Yang JJ. Xu H, et al. J Natl Cancer Inst. 2013 May 15;105(10):733-42. doi: 10.1093/jnci/djt042. Epub 2013 Mar 19. J Natl Cancer Inst. 2013. PMID: 23512250 Free PMC article.

198

Clinical significance of CD33 nonsynonymous single-nucleotide polymorphisms in pediatric patients with acute myeloid leukemia treated with gemtuzumab-ozogamicin-containing chemotherapy.

Mortland L, Alonzo TA, Walter RB, Gerbing RB, Mitra AK, Pollard JA, Loken MR, Hirsch B, Raimondi S, Franklin J, Pounds S, Cao X, Rubnitz JE, Ribeiro RC, Gamis A, Meshinchi S, Lamba JK. Mortland L, et al. Clin Cancer Res. 2013 Mar 15;19(6):1620-7. doi: 10.1158/1078-0432.CCR-12-3115. Epub 2013 Feb 26. Clin Cancer Res. 2013. PMID: 23444229 Free PMC article.

199

Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia.

Urtishak KA, Edwards AY, Wang LS, Hudome A, Robinson BW, Barrett JS, Cao K, Cory L, Moore JS, Bantly AD, Yu QC, Chen IM, Atlas SR, Willman CL, Kundu M, Carroll AJ, Heerema NA, Devidas M, Hilden JM, Dreyer ZE, Hunger SP, Reaman GH, Felix CA. Urtishak KA, et al. Blood. 2013 Apr 4;121(14):2689-703. doi: 10.1182/blood-2012-04-425033. Epub 2013 Feb 7. Blood. 2013. PMID: 23393050 Free PMC article. Clinical Trial.

200

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia.

Meyer JA, Wang J, Hogan LE, Yang JJ, Dandekar S, Patel JP, Tang Z, Zumbo P, Li S, Zavadil J, Levine RL, Cardozo T, Hunger SP, Raetz EA, Evans WE, Morrison DJ, Mason CE, Carroll WL. Meyer JA, et al. Nat Genet. 2013 Mar;45(3):290-4. doi: 10.1038/ng.2558. Epub 2013 Feb 3. Nat Genet. 2013. PMID: 23377183 Free PMC article.

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