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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 3
1947 4
1948 3
1949 3
1950 3
1951 11
1952 9
1953 6
1954 12
1955 7
1956 5
1957 14
1958 14
1959 17
1960 19
1961 19
1962 23
1963 46
1964 61
1965 70
1966 180
1967 215
1968 214
1969 200
1970 209
1971 186
1972 199
1973 231
1974 297
1975 368
1976 408
1977 603
1978 982
1979 1194
1980 15685
1981 33527
1982 34552
1983 35009
1984 36722
1985 37425
1986 38598
1987 39963
1988 41078
1989 42719
1990 44831
1991 46118
1992 46703
1993 47436
1994 48931
1995 49317
1996 49506
1997 49843
1998 50837
1999 52358
2000 54943
2001 56287
2002 59379
2003 63599
2004 71263
2005 77912
2006 86520
2007 93099
2008 103258
2009 110069
2010 119459
2011 128533
2012 133194
2013 138277
2014 139641
2015 140805
2016 136233
2017 131691
2018 134222
2019 136120
2020 148763
2021 155956
2022 143519
2023 144648
2024 138857
2025 129553
2026 29997
2028 1

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Page 1
The Association of Preoperative Cognitive Dysfunction to Common Intraoperative Electroencephalographic Parameters and Cerebral Hypoxia During Cardiac Surgery.
Behera A, Ramachandran RV, Hussain Z, Ihalainen RJ, Orui H, Peck J, Ananthakrishnan A, Mathur P, Muehlschlegel JD, Pittet JF, Bardia A, Schonberger RB, Kveraga K, Subramaniam B. Behera A, et al. Anesth Analg. 2026 May 1;142(5):964-974. doi: 10.1213/ANE.0000000000007724. Epub 2026 Apr 14. Anesth Analg. 2026. PMID: 41980267 Clinical Trial.
Outcomes After Minor Ischemic Stroke in Older Patients Treated With IV Thrombolysis vs Standard of Care in the TEMPO-2 Trial.
Ganesh A, Vatanpour S, Yu AYX, Barber P, Choi PMC, Field TS, Kate MP, Kleinig TJ, Shamy MCF, Chatterjee K, Molina CA, Campbell BCV, Appireddy R, Muir KW, Hill MD, Coutts SB; as the TEMPO-2 investigators. Ganesh A, et al. Neurology. 2026 May 12;106(9):e214925. doi: 10.1212/WNL.0000000000214925. Epub 2026 Apr 14. Neurology. 2026. PMID: 41980227 Clinical Trial.
Secondary outcomes included neurologic recovery according to the NIH Stroke Scale (NIHSS) at 5 days/discharge, vessel recanalization, Lawton Instrumental Activities of Daily Living Scale, EuroQol-5 Dimension (EQ-5D), and adverse events. ...
Secondary outcomes included neurologic recovery according to the NIH Stroke Scale (NIHSS) at 5 days/discharge, vessel recanalization, …
Distinct evolutionary patterns of endemic and emerging parvoviruses and the origin of a new pandemic virus.
López-Astacio RA, Wasik BR, Lee H, Voorhees IEH, Weichert WS, Adu OF, Goodman LB, Hafenstein SL, Truyen U, Parrish CR. López-Astacio RA, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2515274123. doi: 10.1073/pnas.2515274123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980105
Emergence of epidemic viruses in new hosts threatens both human and other animal populations, and often involves virus evolution to overcome barriers that normally prevent efficient infection and spread in that host. ...
Emergence of epidemic viruses in new hosts threatens both human and other animal populations, and often involves virus evolution to o …
A plasma-based DNA test for quantification of disease burden in acute myeloid leukemia patients undergoing bone marrow transplantation.
Wang Y, Xie J, Pasca S, Popoli M, Ptak J, Dobbyn L, Silliman N, Paul S, Jones RJ, Levis MJ, Curtis SD, Douville C, Shams C, Guo MZ, Mo S, Gocke CD, Malek SN, Bollard CM, Bettegowda C, Kinzler KW, Vogelstein B, Papadopoulos N, Gondek LP. Wang Y, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2537987123. doi: 10.1073/pnas.2537987123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980102
Evidence for strong purifying selection of human 47S ribosomal RNA genes.
Ma X, Chow F, Galbraith B, Sultanov D, Behar EK, Hochwagen A. Ma X, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2529741123. doi: 10.1073/pnas.2529741123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980101
The multicopy 47S ribosomal RNA (rRNA) genes are among the most highly expressed genes in the human genome, yet to-date essentially no disease-causing sequence variants have been identified. ...Here, we used an evolutionary approach to test whether mutations in the …
The multicopy 47S ribosomal RNA (rRNA) genes are among the most highly expressed genes in the human genome, yet to-date essent …
Trem2 exacerbates ischemic brain injury through Gpnmb in a photothrombotic stroke model.
Chen X, Li K, Liu S, Zhao J, Tiwari S, Zeng F, Zhao Y, Zhang P, Tang H, Zhao H, Kettenmann H, Xiang X, Zhu X. Chen X, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2523148123. doi: 10.1073/pnas.2523148123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980098
Ischemic stroke is a major public health challenge, with microglia-mediated neuroinflammation exerting both protective and detrimental effects on neuronal survival. ...Conversely, intracerebral administration of sTrem2 exacerbated neuronal loss, amplified inflammation, and …
Ischemic stroke is a major public health challenge, with microglia-mediated neuroinflammation exerting both protective and detrimenta …
Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors.
Brown DA, Koll KK, Brush E, Darner G, Curtis T Jr, Dvergsten T, Tran M, Milligan C, Wolfson DW, Gonzalez TJ, Jeffs S, Ehrhardt A, Bitolas R, Landau M, Reitz K, Salven DS, Slota-Burtt LA, Snee I, Singer-Freeman E, Bhatia S, Ou J, Asokan A, Currie JD, Poss KD. Brown DA, et al. Proc Natl Acad Sci U S A. 2026 Apr 28;123(17):e2532804123. doi: 10.1073/pnas.2532804123. Epub 2026 Apr 14. Proc Natl Acad Sci U S A. 2026. PMID: 41980086
Updated consensus guidelines for the diagnosis and management of patients with hairy cell leukemia (HCL) and HCL-variant.
Zent CS, Tiacci E, Kreitman RJ, Tadmor T, Tallman MS, Wörmann BJ, Andritsos LA, Arons E, Banerji V, Barrientos JC, Bhat SA, Blachly JS, Broccoli A, Call TG, Dearden C, Demeter J, Dietrich S, El-Sharkawi D, Fagarasanu A, Falini B, Forconi F, Gerrie AS, Gladstone DE, Gozzetti A, Hampel PJ, Hermel DJ, Iyengar S, Johnston JB, Juliusson G, Kipps TJ, Lauria F, Lozanski G, Parikh SA, Park JH, Polliack A, Quest G, Rai KR, Ravandi F, Robak T Prof, Rogers KA, Saven A, Seymour JF, Tam CS, Troussard X, Zenz T, Zinzani PL, Grever MR. Zent CS, et al. Blood. 2026 Apr 14:blood.2025032757. doi: 10.1182/blood.2025032757. Online ahead of print. Blood. 2026. PMID: 41980020
Protein kinase C theta: evolution, regulation, and function.
Hodapp SJ, Manning G, Newton AC. Hodapp SJ, et al. Biochem J. 2026 May 6;483(5):603-620. doi: 10.1042/BCJ20250280. Biochem J. 2026. PMID: 41979916 Review.
However, unlike the extensively studied Ca2+-regulated conventional PKC isozymes, the mechanisms of PKCtheta and its roles in both health and disease remain relatively unexplored. In this review, we examine the evolution of PKCtheta, its domain structure and lifecycle, its …
However, unlike the extensively studied Ca2+-regulated conventional PKC isozymes, the mechanisms of PKCtheta and its roles in both health …
Overlaps in mammalian iron and manganese homeostasis: recent advances.
Prajapati M, Chiu L, Akpengbe J, Costeas C, Bartnikas TB. Prajapati M, et al. Biometals. 2026 Apr 14. doi: 10.1007/s10534-026-00808-8. Online ahead of print. Biometals. 2026. PMID: 41979805 Review.
Notably, while manganese is best known as a neurotoxicant, multiple recent studies have reported that variations in manganese levels correlate with a wide variety of parameters of health and disease. We then highlight deficiency in the manganese transport protein SLC30A10, …
Notably, while manganese is best known as a neurotoxicant, multiple recent studies have reported that variations in manganese levels correla …
Experiences of International and Puerto Rican Medical Graduates in the United States: A Cross-Sectional Survey.
Olazagasti C, Celi CV, Mahtani A, Kiel L, Velazquez AI, Horiguchi M, Sridhar A, Gonzalez M, Bernabe C, Abioye O, Dizman N, Florez N. Olazagasti C, et al. J Gen Intern Med. 2026 Apr 14. doi: 10.1007/s11606-026-10392-9. Online ahead of print. J Gen Intern Med. 2026. PMID: 41979730
We conducted a study to investigate reasons for migration, perceived barriers, discrimination, satisfaction, and factors influencing IMGs' and PRMGs' decisions to remain in the U.S. versus return to their home countries. METHODS: We conducted a cross-sectional, onli …
We conducted a study to investigate reasons for migration, perceived barriers, discrimination, satisfaction, and factors influencing IMGs' a …
Clonal Signatures of Telomere Biology Disorders.
Arcuri L, Groarke EM, Savage SA, Gutierrez-Rodrigues F. Arcuri L, et al. Curr Hematol Malig Rep. 2026 Apr 14;21(1):9. doi: 10.1007/s11899-026-00777-2. Curr Hematol Malig Rep. 2026. PMID: 41979702 Review. No abstract available.
Salmonellosis in Poland in 2023.
Milczarek-Lisicka M, Czarkowski MP, Sadkowska-Todys M. Milczarek-Lisicka M, et al. Przegl Epidemiol. 2026 Mar 3;79(4):699-715. doi: 10.32394/pe/218175. Epub 2026 Feb 19. Przegl Epidemiol. 2026. PMID: 41979590 English, Polish.
Paratyphi) and remains a significant public health concern in Poland and worldwide. According to the CDC, the true burden of infection may be substantially underestimated. ...MATERIAL AND METHODS: The analysis was based on individual case data on salmonellosis, data on foo …
Paratyphi) and remains a significant public health concern in Poland and worldwide. According to the CDC, the true burden of infectio …
Pertussis in Poland in 2023.
Rumik A, Paradowska-Stankiewicz I. Rumik A, et al. Przegl Epidemiol. 2026 Mar 3;79(4):690-698. doi: 10.32394/pe/218544. Epub 2026 Mar 2. Przegl Epidemiol. 2026. PMID: 41979589 English, Polish.
MATERIAL AND METHODS: The assessment of the epidemiological situation of pertussis in Poland was made based on the results of the analysis of individual reports on pertussis cases registered at the National Institute of Public Health NIH - National …
MATERIAL AND METHODS: The assessment of the epidemiological situation of pertussis in Poland was made based on the results of the analysis o …
Lyme disease in Poland in 2023.
Zbrzeżniak JM, Paradowska-Stankiewicz I. Zbrzeżniak JM, et al. Przegl Epidemiol. 2026 Mar 3;79(4):682-689. doi: 10.32394/pe/216677. Epub 2026 Jan 15. Przegl Epidemiol. 2026. PMID: 41979588 English, Polish.
BACKGROUND: Lyme disease is a vector-borne disease transmitted by ticks of the Ixodes genus, caused by a heterogeneous group of Borrelia burgdorferi sensu lato. Human infection occurs through a tick bite and its feeding on the skin. Due to the diverse symptoms, diagnosing …
BACKGROUND: Lyme disease is a vector-borne disease transmitted by ticks of the Ixodes genus, caused by a heterogeneous group of Borrelia bur …
Syphilis in Poland in 2023.
Niedźwiedzka-Stadnik M, Zakrzewska K. Niedźwiedzka-Stadnik M, et al. Przegl Epidemiol. 2026 Mar 3;79(4):650-663. doi: 10.32394/pe/218342. Epub 2026 Feb 27. Przegl Epidemiol. 2026. PMID: 41979586 English, Polish.
Additionally aggregated data from MZ-56 reports on infectious diseases, infections and poisoning from 2017 to 2019 sent from Sanitary Inspections to NIPH NIH - NRI was used. Also, data about treatment patients in dermatology/venereology clinics in 2020-2023 reported on MZ- …
Additionally aggregated data from MZ-56 reports on infectious diseases, infections and poisoning from 2017 to 2019 sent from Sanitary Inspec …
HIV infections and AIDS in Poland in 2023.
Niedźwiedzka-Stadnik M, Nowakowska-Radziwonka E, Marzec-Bogusławska A. Niedźwiedzka-Stadnik M, et al. Przegl Epidemiol. 2026 Mar 3;79(4):633-649. doi: 10.32394/pe/217374. Epub 2026 Feb 3. Przegl Epidemiol. 2026. PMID: 41979585 English, Polish.
Frailty and Brain Myelin Across Adulthood: Multimodal MRI Insights From the BLSA.
Bouhrara M, Gong Z, Tanaka T, Ferrucci L. Bouhrara M, et al. Aging Cell. 2026 Apr;25(4):e70489. doi: 10.1111/acel.70489. Aging Cell. 2026. PMID: 41979393
Frailty is a state of reduced physiological resilience and increased vulnerability to adverse health outcomes, but its neurobiological mechanisms across the adult lifespan remain unclear. ...The study highlights myelin degradation as a candidate neural substrate of frailty …
Frailty is a state of reduced physiological resilience and increased vulnerability to adverse health outcomes, but its neurobiologica …
Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth.
Staples JW, Killam SR, Brown KE, Dalton R, Sather E, Chen Q, Loveland J, Schwanke C, Elias AF, Bigos KL, Woodahl EL. Staples JW, et al. Clin Pharmacol Ther. 2026 Apr 14. doi: 10.1002/cpt.70287. Online ahead of print. Clin Pharmacol Ther. 2026. PMID: 41979230
Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited. We conducted a genome-wide association study (GWAS) to investigate genetic predictors of risperidone response in pediatric patients (n = 161) who rece …
Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited. We conducted a …
Dependence of cell fate potential and cadherin switching on the coordinate within the primitive streak during differentiation of human pluripotent stem cells.
Zhu Y, Warmflash A. Zhu Y, et al. Development. 2026 Apr 1;153(7):dev204807. doi: 10.1242/dev.204807. Epub 2026 Apr 14. Development. 2026. PMID: 41979195
We made measurements of these processes during differentiation of human pluripotent stem cells to PS and downstream mesendoderm subtypes using established protocols and variants in which signaling through key pathways, including activin, BMP and Wnt, were modulated. ...
We made measurements of these processes during differentiation of human pluripotent stem cells to PS and downstream mesendoderm subty …
Renin-Angiotensin-Aldosterone System (RAAS) in Pig-to-Baboon Kidney Xenotransplantation-Relevance to Clinical Pig Kidney Xenotransplantation.
Terashita M, Kinoshita K, Satou R, Katsurada A, Lavalla GE, Maenaka A, Hidaka Y, Rosales IA, Ayares D, Kawai T, Navar LG, Cooper DKC. Terashita M, et al. Xenotransplantation. 2026 Mar-Apr;33(2):e70129. doi: 10.1111/xen.70129. Xenotransplantation. 2026. PMID: 41979182
BACKGROUND: Pig-to-human kidney xenotransplantation offers a potential solution to the organ shortage. However, the ability of the transplanted pig kidney to regulate blood pressure and fluid balance remains uncertain. ...However, the retention of a native kidney may help …
BACKGROUND: Pig-to-human kidney xenotransplantation offers a potential solution to the organ shortage. However, the ability of the tr …
Clinical Research Facilitators, Barriers, and Preferences of Parents of Children With Overweight and Obesity.
Lim CS, Patel DJ, Casady H, Sandridge S, Dodd CA, Malloch L, Annett RD. Lim CS, et al. J Dev Behav Pediatr. 2026 Apr 14. doi: 10.1097/DBP.0000000000001482. Online ahead of print. J Dev Behav Pediatr. 2026. PMID: 41979151
RESULTS: Parents endorsed more reasons and benefits for participation than mistrust, social pressure, and reasons against participation. Lower child body mass index was associated with higher perceptions of research participation benefits. Pandemic parental stress w …
RESULTS: Parents endorsed more reasons and benefits for participation than mistrust, social pressure, and reasons against participati …
Circadian rest/activity rhythms and change in MRI-derived brain volumes: Differences by age in a cognitively healthy sample.
Kaizi-Lutu MA, Callow DD, Rabinowitz JA, Lucey BP, An Y, Wu MN, Zipunnikov V, Bakker A, Davatzikos C, Simonsick EM, Walker KA, Ferrucci L, Resnick SM, Spira AP. Kaizi-Lutu MA, et al. Alzheimers Dement. 2026 Apr;22(4):e71190. doi: 10.1002/alz.71190. Alzheimers Dement. 2026. PMID: 41979141
DISCUSSION: Results link RARs with medial temporal lobe and global brain volumes and indicate that these associations may differ by age. Research is needed on the effects of RAR-focused interventions on brain health....
DISCUSSION: Results link RARs with medial temporal lobe and global brain volumes and indicate that these associations may differ by age. …
The policy exposome of dementia: Gaps, opportunities, and research agenda.
Kieny C, Marks G, Bourgeois M, Alladi S, Atshan S, Brayne C, Dow W, Glymour M, Knapp D, Livingston G, Mahmud M, Monnet N, Papanicolas I, Platt E, Rehkopf D, Sadana R, Wallace L, Walsh S, Wenner M, Avendano M. Kieny C, et al. Alzheimers Dement. 2026 Apr;22(4):e71362. doi: 10.1002/alz.71362. Alzheimers Dement. 2026. PMID: 41979011
We introduce the concept of the policy exposome and summarize findings from a structured expert consultation conducted by the Gateway Exposome Coordinating center (GECC) to identify priority policy research domains. We argue that systematic collection and harmonization of …
We introduce the concept of the policy exposome and summarize findings from a structured expert consultation conducted by the Gateway Exposo …
Clinical Characteristics and Risk Factors for Syphilis Among People Living With Human Immunodeficiency Virus: A Nationwide Population-Based Cohort Study in Korea.
Kim S, Baek YJ, Lee E, Choi Y, Jeong O, Jung J, Kim TH, Choi JY. Kim S, et al. J Korean Med Sci. 2026 Apr 13;41(14):e115. doi: 10.3346/jkms.2026.41.e115. J Korean Med Sci. 2026. PMID: 41978926
BACKGROUND: The incidence of syphilis, a re-emerging infection linked to human immunodeficiency virus (HIV) through shared transmission routes, is increasing among people living with human immunodeficiency virus (PLH) in Korea. This study evaluate the prevalence, te …
BACKGROUND: The incidence of syphilis, a re-emerging infection linked to human immunodeficiency virus (HIV) through shared transmissi …
Efficacy and Tolerability of Viloxazine Extended-Release for Attention-Deficit/Hyperactivity Disorder in Adolescents and Adults: A Systematic Review With Qualitative Synthesis of All Studies and Meta-Analysis of Adolescent Data.
Chapman SR, Roberti C, Abouafech A, Mueller M. Chapman SR, et al. Cureus. 2026 Mar 13;18(3):e105176. doi: 10.7759/cureus.105176. eCollection 2026 Mar. Cureus. 2026. PMID: 41978610 Free PMC article. Review.
Adult outcomes were summarized descriptively due to limited data. Risk of bias was assessed using the National Institute of Health (NIH) Study Quality Assessment Tool. Safety outcomes were assessed qualitatively. ...The findings overall support viloxaz …
Adult outcomes were summarized descriptively due to limited data. Risk of bias was assessed using the National Institute of …
A multitransmitter, synaptic specification-segregated calyx-like synapse linking pontine pituitary adenylate cyclase-activating polypeptide neurons to forebrain-extended amygdala.
Zhang L, Hernández VS, Giraldo DM, Jiang SZ, León-Contreras JC, Ye R, Zhang S, Schäfer MKH, Barrio RA, Hernández-Pando R, Schoenherr S, Ferraguti F, Eiden LE. Zhang L, et al. PNAS Nexus. 2026 Mar 23;5(4):pgag083. doi: 10.1093/pnasnexus/pgag083. eCollection 2026 Apr. PNAS Nexus. 2026. PMID: 41978577 Free PMC article.
Clinical use and radiological yield of magnetic resonance fingerprinting in epilepsy.
Parfyonov M, Su TY, Choi JY, Blümcke I, Sakaie K, Morris S, Murakami H, Alexopoulos A, Najm I, Ma D, Jones SE, Wang ZI. Parfyonov M, et al. Epilepsia. 2026 Apr 14. doi: 10.1002/epi.70203. Online ahead of print. Epilepsia. 2026. PMID: 41978567
Although interest in MRF for epilepsy research has grown in recent years, systematic evaluation of its radiological and clinical value as a supplementary imaging modality is limited. ...
Although interest in MRF for epilepsy research has grown in recent years, systematic evaluation of its radiological and clinical valu …
Complex Substrates and Bedding for Environmental Enhancement and Research: Or, the Nature of Primates.
Sayers K, Allen J, Bellanca RU, Brown T, Coleman K, Janavaris M, Khuu JH, Lee GH, Perlman JE, Pomerantz O, Rosga M. Sayers K, et al. Am J Primatol. 2026 Apr;88(4):e70149. doi: 10.1002/ajp.70149. Am J Primatol. 2026. PMID: 41978564 Review.
A literature review, along with an informal survey and focus group involving individuals at the National Primate Research Centers and affiliated institutions, provides logistical information relevant to the selection of substrates, their respective advantages and di …
A literature review, along with an informal survey and focus group involving individuals at the National Primate Research Cent …
Thread Depth Effects on Stability and Positional Accuracy in Guided Immediate Implants: A Randomized Controlled Trial.
Kwon NY, Jung JY, Ko KA, Park SH, Strauss FJ, Lee JS. Kwon NY, et al. Clin Implant Dent Relat Res. 2026 Apr;28(2):e70145. doi: 10.1111/cid.70145. Clin Implant Dent Relat Res. 2026. PMID: 41978331 Clinical Trial.
Deeper-thread designs may be beneficial when enhanced primary stability is required, provided careful angulation control is ensured. TRIAL REGISTRATION: cris.nih.go.kr Identifier: KCT0009402; This clinical trial was not registered prior to participant recruitment and rando …
Deeper-thread designs may be beneficial when enhanced primary stability is required, provided careful angulation control is ensured. TRIAL R …
Ubiquitylation of DNA polymerase β via atypical K27 chains signals a DNA damage response.
Fang Q, Koczor CA, Roos WP, McClellan S, Andrews JF, Sobol RW. Fang Q, et al. Nucleic Acids Res. 2026 Apr 13;54(7):gkag344. doi: 10.1093/nar/gkag344. Nucleic Acids Res. 2026. PMID: 41978267
These findings demonstrate that atypical ubiquitin chain modifications play crucial roles in DNA repair and the DNA damage response, underscoring the unexpected importance of these chain topologies in maintaining genome integrity....
These findings demonstrate that atypical ubiquitin chain modifications play crucial roles in DNA repair and the DNA damage response, undersc …
Perceived Stress and Associations Between Food Insecurity, Diet Quality, and Eating Behaviors: Evidence from Two Cross-Sectional Studies in U.S. Samples.
Figueroa DG, Cisneroz A, Stiver CA, Tiongco-Hofschneider L, Laraia BA, Epel ES, Tomyiama AJ. Figueroa DG, et al. Nutrients. 2026 Apr 3;18(7):1153. doi: 10.3390/nu18071153. Nutrients. 2026. PMID: 41978203
Methods: Study 1 used cross-sectional data from the National Heart, Lung, and Blood Institute Growth and Health Study (N = 624), in which Black and white women completed self-report measures of food security, perceived stress, diet quality, and reward-based e …
Methods: Study 1 used cross-sectional data from the National Heart, Lung, and Blood Institute Growth and Health Study ( …
Dietary Pattern-Induced Gut Microbiota Differences Are Associated with White Matter Volume Changes in Middle-Aged Female Macaques.
Frye BM, Cooper H, Negrey JD, Sutphen C, Nagpal R, Kim J, Barcus RA, Lockhart SN, Whitlow CT, Tooze JA, Yadav H, Craft S, Register TC, Shively CA. Frye BM, et al. Nutrients. 2026 Mar 31;18(7):1124. doi: 10.3390/nu18071124. Nutrients. 2026. PMID: 41978176
Methods: We determined the effects of long-term (31 months, ~9 human years) consumption of a Mediterranean or Western-type diet on Oscillospira abundance, fecal SCFAs, plasma BCAAs, soluble CD14 (sCD14), and insulin responses in a randomized trial of 38 middle-aged female …
Methods: We determined the effects of long-term (31 months, ~9 human years) consumption of a Mediterranean or Western-type diet on Os …
Seconds-Resolved Measurements of Vancomycin Transport from the Plasma to the Interstitial Fluid Highlight a Path Towards Real-Time Therapeutic Drug Monitoring.
Gerson J, Erdal MK, Fetter LC, Leung KK, Emmons NA, Hespanha J, Kirkpatrick CM, Plaxco KW, Kippin TE. Gerson J, et al. Sensors (Basel). 2026 Apr 4;26(7):2233. doi: 10.3390/s26072233. Sensors (Basel). 2026. PMID: 41978019
Continuous, in vivo drug and biomarker measurements could transform healthcare, enabling both the high-precision personalization of drug dosing and the real-time monitoring of health status. A practical realization of this vision, however, requires an improved understandin …
Continuous, in vivo drug and biomarker measurements could transform healthcare, enabling both the high-precision personalization of drug dos …
DPP6 Loss Causes Age-Dependent Sleep Dysregulation and Depression-like Phenotypes Linked to Neurodegeneration.
Lin L, Pratt AE, Hoffman DA. Lin L, et al. Int J Mol Sci. 2026 Apr 2;27(7):3224. doi: 10.3390/ijms27073224. Int J Mol Sci. 2026. PMID: 41977406
The progressive nature of sleep dysfunction in DPP6-KO mice, from REM abnormalities to insomnia, parallels human disease progression and positions DPP6 as a potential therapeutic target for sleep-related symptoms in neurodegenerative disorders....
The progressive nature of sleep dysfunction in DPP6-KO mice, from REM abnormalities to insomnia, parallels human disease progression …
HIV Promoters Isolated from Brain and Peripheral Tissue of Virally Suppressed PWH Are Phylogenetically and Functionally Similar.
Jamal Eddine J, Chalmers EK, Zhou J, Byrnes SJ, Jenkins TA, Osman N, Hearps AC, Roche M, Angelovich TA, Churchill MJ. Jamal Eddine J, et al. Int J Mol Sci. 2026 Mar 31;27(7):3185. doi: 10.3390/ijms27073185. Int J Mol Sci. 2026. PMID: 41977374
Despite viral suppression with antiretroviral therapy (ART), reservoirs of Human Immunodeficiency Virus (HIV) persist in anatomical compartments throughout the body, including the brain. ...HIV LTRs were extracted from frontal cortex post-mortem brain and matched periphera …
Despite viral suppression with antiretroviral therapy (ART), reservoirs of Human Immunodeficiency Virus (HIV) persist in anatomical c …
Tissue-Specific Expression of the EWSR1::FLI1 Fusion Protein Identifies col2a1a-Positive Cells as a Source of Ewing Sarcoma-like Tumors in Zebrafish.
Anderson RA, Chen X, Oyarbide U, Alvarez NJ, Sievers A, Schwartz GK, Corey SJ. Anderson RA, et al. Int J Mol Sci. 2026 Mar 30;27(7):3131. doi: 10.3390/ijms27073131. Int J Mol Sci. 2026. PMID: 41977317
Here, we report that tissue-specific expression of EWSR1::FLI1 in zebrafish induces tumor formation that recapitulates the histologic and molecular hallmarks of human ES, including small round blue cell morphology and characteristic biomarker expression. ...
Here, we report that tissue-specific expression of EWSR1::FLI1 in zebrafish induces tumor formation that recapitulates the histologic and mo …
Naproxen and Ibuprofen Exposure Alter the Blood-Testis Barrier in a Novel In Vitro Model.
Crow KMS, Cho IK, Edenfield RC, Easley KF, Planinić A, Younis N, Waters E, McClellan JS, Zielen AC, Tager K, Castro C, Simerly C, Orwig KE, Ježek D, Koval M, Easley CA 4th. Crow KMS, et al. Int J Mol Sci. 2026 Mar 26;27(7):3033. doi: 10.3390/ijms27073033. Int J Mol Sci. 2026. PMID: 41977223
Utilizing an in vitro rhesus macaque non-human primate (NHP) BTB model, we demonstrate that serum levels of naproxen and ibuprofen alter the function of BTB. ...Specifically, the genes that were significantly expressed in response to ibuprofen exposure were enriched for …
Utilizing an in vitro rhesus macaque non-human primate (NHP) BTB model, we demonstrate that serum levels of naproxen and ibuprofen al …
Ensemble of Time-Evolving SASP Gene Sets Identifies IGFBP7 and CDKN1A as a Potential Marker Pair for Senescent Fibroblast Subpopulations Across Tissues.
Kim H, Kummerfeld E, Niedernhofer LJ, Aliferis C, Robbins PD, Wang J. Kim H, et al. Int J Mol Sci. 2026 Mar 26;27(7):3012. doi: 10.3390/ijms27073012. Int J Mol Sci. 2026. PMID: 41977201
Applying SASP scores derived from this ensemble of gene sets (SASP scores/EGS) to publicly available scRNA-seq datasets from human lung, skin, and eye tissues enabled the identification of senescent fibroblasts and revealed IGFBP7 as a consistently upregulated marker in p2 …
Applying SASP scores derived from this ensemble of gene sets (SASP scores/EGS) to publicly available scRNA-seq datasets from human lu …
Growth Differentiation Factor 15 and Physical Function Impairment in the SardiNIA Study.
Profili NI, Fiorillo E, Orrù V, Benelli M, Cucca F, Delitala AP. Profili NI, et al. J Clin Med. 2026 Mar 29;15(7):2612. doi: 10.3390/jcm15072612. J Clin Med. 2026. PMID: 41976911 Free PMC article.
GDF-15 may be considered a proxy for reduced physical performance. Future research is needed to understand the pathogenetic role of GDF-15 in the reduction in skeletal muscle in aging people....
GDF-15 may be considered a proxy for reduced physical performance. Future research is needed to understand the pathogenetic role of G …
Comparative Proteomic Analysis of Lipoprotein(a): Method-Dependent Profiles and Disease Pathways.
Matienzo N, Kress Z, Singh SA, Aikawa M, Soni RK, Li Y, Reyes-Soffer G. Matienzo N, et al. J Clin Med. 2026 Mar 27;15(7):2559. doi: 10.3390/jcm15072559. J Clin Med. 2026. PMID: 41976861 Free PMC article.
Methods: Lp(a) was immunoprecipitated from human plasma using an apo(a)-specific monoclonal antibody and analyzed by mass spectrometry following either in-gel digestion or automated in-solution proteolysis. ...
Methods: Lp(a) was immunoprecipitated from human plasma using an apo(a)-specific monoclonal antibody and analyzed by mass spectrometr …
MDM4 at the Crossroads: Beyond p53 and MDM2.
Thapa D, St John A, Parrales A, Ranjan A, Iwakuma T. Thapa D, et al. Cancers (Basel). 2026 Mar 25;18(7):1059. doi: 10.3390/cancers18071059. Cancers (Basel). 2026. PMID: 41976281 Review.
Advances in Natural Product Extraction: Established and Emerging Technologies.
Travis CR, McMaster J, Rivas F. Travis CR, et al. Molecules. 2026 Mar 30;31(7):1136. doi: 10.3390/molecules31071136. Molecules. 2026. PMID: 41976179 Free PMC article. Review.
Natural product research has experienced substantial growth over the past two decades, driven by a renewed appreciation for the structural complexity and biological relevance of compounds derived from nature. ...Effective extraction and isolation remain foundational to nat …
Natural product research has experienced substantial growth over the past two decades, driven by a renewed appreciation for the struc …
Rational Design and Evaluation of Novel TGR5 Agonists for Diabetes.
Bhimanwar RS, Detwiler Z, Zhu JG, Saghafi ST, Winder CA, Davis DB, Mittal A, Sharma V, Harris DA, Chaudhari SN. Bhimanwar RS, et al. Molecules. 2026 Mar 26;31(7):1093. doi: 10.3390/molecules31071093. Molecules. 2026. PMID: 41976136 Free PMC article.
Experienced and Anticipated Intersectional Violence and Psychological Distress Symptom Severity Among Black Transgender Women in the United States of America.
Sherman ADF, Balthazar MS, Ruiz AM, Berish D, Szczech M, Wishloff S, Pelkmans J, Kim G, Schneider JS, Operario D, Together We Thrive Community Advisory Board, Cimino AN. Sherman ADF, et al. Healthcare (Basel). 2026 Apr 2;14(7):932. doi: 10.3390/healthcare14070932. Healthcare (Basel). 2026. PMID: 41975934 Free PMC article.
Although victimization is linked to psychological distress, the mental health impacts of intersectional violence, which targets overlapping marginalized identities, remain understudied. ...CONCLUSIONS: Service providers who work with Black transgender women should routinel …
Although victimization is linked to psychological distress, the mental health impacts of intersectional violence, which targets overl …
Factors That Influence Burnout of Clinical and Research Faculty: New Insights of Data from a United States Cancer Center Using CART Analysis.
Chang S, Lee HY, Cavanaugh KJ, Holladay CL. Chang S, et al. Healthcare (Basel). 2026 Apr 2;14(7):926. doi: 10.3390/healthcare14070926. Healthcare (Basel). 2026. PMID: 41975928 Free PMC article.
Background/Objectives: Burnout among academic health professionals affects well-being and performance of critical responsibilities-clinical, research, administrative, and teaching. Despite growing attention, study limitations hinder understanding the mechanisms of b …
Background/Objectives: Burnout among academic health professionals affects well-being and performance of critical responsibilities-cl …
Association between Clostridioides difficile Test Positivity and Colorectal Cancer Incidence in a Multisite Hospital-Based Retrospective Cohort Analysis.
Rifkin S, Anderson SM, Chen X, Gebo K, Klein E, Markham NO, Robinson M, Rao K, Sears CL. Rifkin S, et al. Cancer Res Commun. 2026 Apr 1;6(4):821-831. doi: 10.1158/2767-9764.CRC-25-0606. Cancer Res Commun. 2026. PMID: 41975657
These findings help translate emerging mouse model work on C. difficile-influenced colorectal tumorigenesis and lay groundwork for more substantial human investigations into this connection. These findings also may begin to help guide the personalized deployment of novel f …
These findings help translate emerging mouse model work on C. difficile-influenced colorectal tumorigenesis and lay groundwork for more subs …
35 Individuals With HUWE1-Related Neurodevelopmental Disorder and Suggested Clinical Evaluations.
Li MH, Coleman DL, Hogan K, Luz D, Bhandari L, Belnap N, Busa T, Coutton C, Dieterich K, Gorokhova S, Hildebrandt C, Logan R, Mariani M, Morleo M, Nigro V, Pappas J, Rabin R, Schoch K, Selicorni A, Shashi V, Spillmann R, Sullivan J, Tardy C, Vergano SAS, Grill B, Baranano K. Li MH, et al. Am J Med Genet A. 2026 Apr 13. doi: 10.1002/ajmg.a.70127. Online ahead of print. Am J Med Genet A. 2026. PMID: 41975654
The Feasibility of Home-Based Estimation of Circadian Timing in Veterans With Insomnia and Past Traumatic Brain Injury.
Reis DJ, Armstrong AE, Miller C, Postolache TT, Forster JE, Brenner LA, Bahraini NH. Reis DJ, et al. J Head Trauma Rehabil. 2026 Apr 14. doi: 10.1097/HTR.0000000000001170. Online ahead of print. J Head Trauma Rehabil. 2026. PMID: 41975564
OBJECTIVE: To evaluate the feasibility and acceptability (eg, user experience) of 2 methods for home-based estimation of circadian timing among veterans with insomnia and a history of traumatic brain injury (TBI). SETTING: An outpatient setting at a Department of Veterans …
OBJECTIVE: To evaluate the feasibility and acceptability (eg, user experience) of 2 methods for home-based estimation of circadian timing am …
Regional diffusion imaging measures to disentangle SVD-related hypertensive arteriopathy versus cerebral amyloid angiopathy.
Raghavan S, Przybelski SA, Gebre RK, Low A, Hu M, Reid RI, Windham BG, Wiste HJ, Fought AJ, Kamykowski MG, Nguyen AT, Murray ME, Lowe VJ, Jack CRJ, Petersen RC, Graff-Radford J, Vemuri P; Alzheimer’s Disease Neuroimaging Initiative. Raghavan S, et al. Mol Neurodegener. 2026 Apr 13. doi: 10.1186/s13024-026-00942-4. Online ahead of print. Mol Neurodegener. 2026. PMID: 41975517 No abstract available.
Effectiveness Outcomes from a Social Network Diffusion Intervention to Increase COVID-19 Testing and Vaccination among Individuals Impacted by the Criminal Legal System in Urban U.S. Cities.
Brewer RA, Almirol E, Meyer M, Tong L, Hodge S, Carter C, Arnold S, Vasquez L, Dawdani A, Webb J, Payne D, Johns MM, Pyra MM, Bouris AM, Wu EL, Payne G, Horton H, Johnson O, Knopf A, Zapolski TC, Aalsma MC, Zaller N, Schneider JA. Brewer RA, et al. J Urban Health. 2026 Apr 13. doi: 10.1007/s11524-026-01070-6. Online ahead of print. J Urban Health. 2026. PMID: 41975156
Social network diffusion interventions are a promising strategy for promoting health behavior change at the community level. Individuals impacted by the criminal legal system (CLS) experienced disproportionately high morbidity and mortality during the COVID-19 pande …
Social network diffusion interventions are a promising strategy for promoting health behavior change at the community level. I …
Cytotoxic Edema and Intra-parenchymal Hemorrhage: A Mediated Pathway to Mortality and Functional Outcome in Cerebral Venous Sinus Thrombosis- A sub-analysis of the CLOT-VENUS Registry.
Abdelhakim N, Galecio-Castillo M, Kalakoti P, Cruz-Criollo L, Rodriguez-Calienes A, Brito A, Cespedes J, Shaban A, Venkatesan A, Nigenda VC, Pompa AAM, Mohr NM, Pereda-Castillo A, Peregrino KE, Ruvalcaba HV, Smith BJ, Torner JC, Barboza MA, Arauz A, Ortega-Gutierrez S. Abdelhakim N, et al. Transl Stroke Res. 2026 Apr 14;17(2):41. doi: 10.1007/s12975-026-01426-9. Transl Stroke Res. 2026. PMID: 41975110
Impact of intensive control on malaria population genomics under elimination settings in Southeast Asia.
Li X, Arya GA, Thu AM, Landier J, Parker DM, Delmas G, Reyes A, Lwin KM, Sriprawat K, Nosten F, Anderson TJC. Li X, et al. Nat Microbiol. 2026 Apr 13. doi: 10.1038/s41564-026-02327-1. Online ahead of print. Nat Microbiol. 2026. PMID: 41975094
Here we examine the impact of control on parasite genomic parameters to inform future control efforts. Using 2,270 genome-sequenced Plasmodium falciparum infections from 283 malaria posts, sampled over 58 months (2015-2020), we find that parasite effective population size …
Here we examine the impact of control on parasite genomic parameters to inform future control efforts. Using 2,270 genome-sequenced P …
An ultrasound-scanning in vivo light source.
Jiang S, Malinao MG, Yang F, Zeng Y, Hou SS, Wu X, Rommelfanger NJ, Chaunsali L, Zhao S, Cui H, Ding J, Chen X, Zhou Q, Sontheimer H, Hong G. Jiang S, et al. Nat Mater. 2026 Apr 13. doi: 10.1038/s41563-026-02556-z. Online ahead of print. Nat Mater. 2026. PMID: 41975079
Gut microbiota-associated predictors as biomarkers of neoadjuvant treatment response in rectal cancer-a systematic review.
Stepanyan A, Kotsafti A, Rosato A, Castagliuolo I, Scarpa M, Scarpa M; IMMUNOREACT Study Group. Stepanyan A, et al. Br J Cancer. 2026 Apr 13. doi: 10.1038/s41416-026-03443-9. Online ahead of print. Br J Cancer. 2026. PMID: 41975041
Two reviewers independently performed screening, data extraction, and quality assessment (NIH and STORMS tools). Due to substantial heterogeneity, a structured qualitative synthesis without meta-analysis was conducted following SWiM guidelines, using a direction-of-effect …
Two reviewers independently performed screening, data extraction, and quality assessment (NIH and STORMS tools). Due to substantial h …
Rare genetic diseases associated with G-quadruplex-induced replication stress.
Herr LM, Mukhopadhyay S, Anderson OM, Couch TH, Jones CM, Brosh RM Jr, Rossi M. Herr LM, et al. Commun Biol. 2026 Apr 13;9(1):522. doi: 10.1038/s42003-026-09966-4. Commun Biol. 2026. PMID: 41975004 Free article. Review.
DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substantial barrier for passage of the replisome, …
DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome …
Characterizing healthcare provider experiences delivering genomic testing in a Federally Qualified Health Center.
Gur-Arie R, Quijada R, Hernandez V, Gonzalez C, Williams AN, Singh DP, Sharp RR, Shaibi GQ. Gur-Arie R, et al. Commun Med (Lond). 2026 Apr 13. doi: 10.1038/s43856-026-01579-6. Online ahead of print. Commun Med (Lond). 2026. PMID: 41974864 Free article.
BACKGROUND: To maximize the potential benefits of genomic medicine for all, it is crucial to research and support the delivery of genomic medicine in under-researched healthcare settings. ...However, qualitative findings emphasize time constraints, insufficient training, l …
BACKGROUND: To maximize the potential benefits of genomic medicine for all, it is crucial to research and support the delivery of gen …
tRNA-deacylase-directed discovery of biosynthetic pathways.
Millar DC, Zhou Y, Marchand JA, Roberts-Mataric H, Chen T, Hu CX, Fang J, Millar S, Stone EA, Pelton JG, Sosa MB, Chang MCY. Millar DC, et al. Nat Chem. 2026 Apr 13. doi: 10.1038/s41557-026-02126-5. Online ahead of print. Nat Chem. 2026. PMID: 41974831
Proinsulin regulators identified with CRISPR screen and in vivo mouse QTL mapping.
Lai S, Keller MP, Zhang J, Fang Z, Xie Y, Weng C, Zhang S, Zhang S, Gao P, Ke L, Wang Y, Mitok KA, Clark L, Schueler KL, Liu H, Hatipoglu B, Hatzoglou M, Chen Y, Shalev A, Jin F, Attie AD, Li Y. Lai S, et al. Nat Commun. 2026 Apr 13. doi: 10.1038/s41467-026-71726-z. Online ahead of print. Nat Commun. 2026. PMID: 41974708 Free article.
Altered proinsulin levels in beta-cells and bloodstream are hallmarks of diabetes and other diseases, but our knowledge about the proinsulin regulators remains limited. Here we perform a genome-wide CRISPR screen to identify 84 proinsulin regulators that alter intracellula …
Altered proinsulin levels in beta-cells and bloodstream are hallmarks of diabetes and other diseases, but our knowledge about the proinsulin …
R-loop landscapes in the developing human brain are linked to neural differentiation and cell type-specific transcription.
LaMarca EA, Saito A, Plaza-Jennings A, Espeso-Gil S, Hellmich A, Fernando MB, Javidfar B, Liao W, Estill M, Townsley K, Florio A, Ethridge JE, Do C, Tycko B, Shen L, Kamiya A, Tsankova NM, Brennand KJ, Akbarian S. LaMarca EA, et al. Transl Psychiatry. 2026 Apr 13. doi: 10.1038/s41398-026-04009-2. Online ahead of print. Transl Psychiatry. 2026. PMID: 41974678 Free article.
Here, we construct genome-scale maps of R-loops, three-stranded nucleic acid structures comprised of a DNA/RNA hybrid and a displaced single strand of DNA, in both proliferative and differentiated zones of the human prenatal brain. ...
Here, we construct genome-scale maps of R-loops, three-stranded nucleic acid structures comprised of a DNA/RNA hybrid and a displaced …
Dasatinib and quercetin senolytic treatment delays early onset intervertebral disc degeneration in SM/J mice.
Novais EJ, Ottone OK, Jagannath S, Akande EJ, Barve RA, Risbud MV. Novais EJ, et al. Bone Res. 2026 Apr 14;14(1):42. doi: 10.1038/s41413-026-00526-4. Bone Res. 2026. PMID: 41974671 Free article.
Notably, the in vitro inhibition studies of the JUN pathway in human degenerated NP cells mimicked the benefits of DQ, namely, a reduction in senescence and SASP. ...
Notably, the in vitro inhibition studies of the JUN pathway in human degenerated NP cells mimicked the benefits of DQ, namely, a redu …
Association of genetic ancestry with outcomes and toxicity of idecabtagene vicleucel in patients with relapsed/refractory multiple myeloma.
Dillard CM, Lee H, Kalariya N, Subramanian N, Pasvolsky O, Ferreri C, Gaballa M, Thomas SK, Weber DM, Becnel M, Kaufman G, Qazilbash M, Orlowski RZ, Hildebrandt MAT, Patel KK. Dillard CM, et al. Blood Cancer J. 2026 Apr 13;16(1):59. doi: 10.1038/s41408-026-01489-9. Blood Cancer J. 2026. PMID: 41974660 Free article. No abstract available.
Effect measure modification in mixtures and public health.
Keil AP. Keil AP. Am J Epidemiol. 2026 Apr 13:kwag081. doi: 10.1093/aje/kwag081. Online ahead of print. Am J Epidemiol. 2026. PMID: 41974449
Methods for studying the health effects of exposure mixtures like air pollutants, water contaminants, and consumer product mixtures have been the subject of high levels of research effort and resources in recent years. ...I close by remarking on how health im …
Methods for studying the health effects of exposure mixtures like air pollutants, water contaminants, and consumer product mixtures h …
A Narrative Review of the Regional Prospective Observational Research in Tuberculosis International Consortium: Sharing Diverse Data and Specimens in the Fight Against Tuberculosis.
Bhavaraju R, Andrade B, Siminski S, Kim S, Hatherill M, Sterling T, Gupta A, Martin D, Sarkar S, Alejandria M, Ellner JJ. Bhavaraju R, et al. Clin Infect Dis. 2026 Apr 13;82(Supplement_2):S53-S59. doi: 10.1093/cid/ciag151. Clin Infect Dis. 2026. PMID: 41974034 Review.
METHODS: RePORT International was created in 2012 by the US National Institute of Allergy and Infectious Diseases (NIAID) with bilateral country funding. ...CONCLUSIONS: Public health research has had funding limitations on ideal patient enrollment and …
METHODS: RePORT International was created in 2012 by the US National Institute of Allergy and Infectious Diseases (NIAID) with …
Long-term Sequelae of Pulmonary Tuberculosis: A Narrative Review.
Gupte AN, Boisson-Walsh A, Huaman MA, Bhavaraju R, Gao Y, Hom D, Ellner J, Kornfeld H. Gupte AN, et al. Clin Infect Dis. 2026 Apr 13;82(Supplement_2):S60-S67. doi: 10.1093/cid/ciag123. Clin Infect Dis. 2026. PMID: 41974033 Review.
Tuberculosis is also associated with increased lung cancer risk independent of smoking exposure, with adenocarcinoma, squamous cell, and small cell carcinomas commonly reported. While ongoing research suggests a key role of a dysfunctional host inflammatory response in the …
Tuberculosis is also associated with increased lung cancer risk independent of smoking exposure, with adenocarcinoma, squamous cell, and sma …
From Exposure to Disease: Predicting Tuberculosis Progression.
Araújo-Pereira M, Bhavaraju R, Hatherill M, Gupta A, Ellner JJ, Sterling TR, Andrade BB. Araújo-Pereira M, et al. Clin Infect Dis. 2026 Apr 13;82(Supplement_2):S68-S74. doi: 10.1093/cid/ciag125. Clin Infect Dis. 2026. PMID: 41974032 Review.
Multinational networks, such RePORT (Regional Prospective Observational Research for TB) International-a consortium of eight country-based networks-have advanced the field through collaboration, data sharing, and large-scale studies across diverse populations. This review …
Multinational networks, such RePORT (Regional Prospective Observational Research for TB) International-a consortium of eight country- …
Asymptomatic Tuberculosis Across the Disease Spectrum: A Scoping Review of Epidemiology, Diagnosis, and Public Health Implications.
Duarte BB, Ellner J, Wright AD, Hatherill M, Gupta A, Sterling TR, Bhavaraju R, Andrade BB. Duarte BB, et al. Clin Infect Dis. 2026 Apr 13;82(Supplement_2):S75-S84. doi: 10.1093/cid/ciag150. Clin Infect Dis. 2026. PMID: 41974031
We selected epidemiological studies, prevalence surveys, modeling analyses, and recent World Health Organization (WHO) guidance to summarize the current understanding of asymptomatic TB. We examined definitions, diagnostic approaches, transmission potential, natural histor …
We selected epidemiological studies, prevalence surveys, modeling analyses, and recent World Health Organization (WHO) guidance to su …
Seladelpar in patients with primary biliary cholangitis and compensated cirrhosis: Efficacy and safety from RESPONSE and ASSURE studies.
Gordon SC, Villamil A, Jacobson IM, Lawitz EJ, Younes Z, Silveira MG, Bowlus CL, Drenth JPH, Vierling JM, Morgera U, Vasura A, Dalekos G, Galli A, Rabinovitz M, Heo J, Nevens F, Levy C, Zhou Y, Carroll S, Crittenden DB. Gordon SC, et al. Hepatol Commun. 2026 Apr 13;10(5):e0918. doi: 10.1097/HC9.0000000000000918. eCollection 2026 May 1. Hepatol Commun. 2026. PMID: 41974026 Free PMC article. Clinical Trial.
A modified CRISPR/Cas9 approach in silencing the triplication in Down syndrome: A treatment path XISTs.
Lian G, Khabazeh A, Sheen V. Lian G, et al. Proc Natl Acad Sci U S A. 2026 Apr 21;123(16):e2517953123. doi: 10.1073/pnas.2517953123. Epub 2026 Apr 13. Proc Natl Acad Sci U S A. 2026. PMID: 41973928
Down syndrome (DS) is one of the most common developmental human genetic disorders and is due to triplication of chromosome 21 (HSA21). Although previous studies using epigenetic suppression of HSA21 by the long noncoding RNA XIST showed a potential for DS treatment, integ …
Down syndrome (DS) is one of the most common developmental human genetic disorders and is due to triplication of chromosome 21 (HSA21 …
Typhoid Toxin of Salmonella enterica Induces ISG15 Responses Mediating Host Cell Survival and Counteracting Intracellular Infection.
Stark DS, King M, Ibler AEM, Srour S, Brown F, Sheffield J, Baseer N, Vernon EG, Zhang Y, Staples C, Radoshevich L, Humphreys D. Stark DS, et al. Mol Microbiol. 2026 Apr 13. doi: 10.1111/mmi.70067. Online ahead of print. Mol Microbiol. 2026. PMID: 41973907
The toxin causes a DNA damage response in human cells, characterised by cell-cycle arrest and cellular distension, resulting in cellular senescence and increased bacterial burden. ...
The toxin causes a DNA damage response in human cells, characterised by cell-cycle arrest and cellular distension, resulting in cellu …
"Appalachia's Katrina": Characterizing the traumatic impact of Hurricane Helene.
Pinciotti CM, Foshee KL, Storch EA. Pinciotti CM, et al. Psychol Trauma. 2026 Apr 13. doi: 10.1037/tra0002158. Online ahead of print. Psychol Trauma. 2026. PMID: 41973785
Its impacts spanned nearly 500 miles and six states; most notably, it devastated economically disadvantaged Appalachian communities hundreds of miles inland who were unprepared to deal with the storm. Previous research provides some insights into contextual and individual …
Its impacts spanned nearly 500 miles and six states; most notably, it devastated economically disadvantaged Appalachian communities hundreds …
Clinical Potential of GIP in Type 2 Diabetes and Obesity.
Nauck M, Gribble F, Reimann F, D'Alessio DA, Campbell JE. Nauck M, et al. Diabetes Care. 2026 Apr 13:dci250141. doi: 10.2337/dci25-0141. Online ahead of print. Diabetes Care. 2026. PMID: 41973737 Review.
Early Pregnancy Central Obesity and Risk of Prenatal and Postpartum Diabetes and Hypertensive Disorders.
Rosen Vollmar AK, Hedderson MM, Ngo AL, Chehab RF, Peterson AK, Greenberg MB, Liao LD, Ames JL, Ferrara A, Zhu Y. Rosen Vollmar AK, et al. Diabetes Care. 2026 Apr 13:dc252812. doi: 10.2337/dc25-2812. Online ahead of print. Diabetes Care. 2026. PMID: 41973635
We investigated associations of central obesity with perinatal cardiometabolic conditions, independently and jointly with BMI. RESEARCH DESIGN AND METHODS: We examined associations of early pregnancy central obesity measures (waist circumference, waist-to-hip ratio, waist- …
We investigated associations of central obesity with perinatal cardiometabolic conditions, independently and jointly with BMI. RESEARCH …
Cholangiocyte Biology in Primary Sclerosing Cholangitis and Other Cholangiopathies: Pathogenesis, Clinical Insights, and Experimental Tools.
Jalan-Sakrikar N, Anwar AA, Ali A, Nasser-Ghodsi N, Felzen A, Huebert RC, LaRusso NF, O'Hara SP. Jalan-Sakrikar N, et al. Physiol Rev. 2026 Apr 13. doi: 10.1152/physrev.00022.2025. Online ahead of print. Physiol Rev. 2026. PMID: 41973609 Review.
Lastly, we provide an overview of existing rodent models of cholangiopathies and discuss their relevance to human disease. PSC remains therapeutically unaddressed, and thus ongoing multidisciplinary efforts are essential to developing targeted interventions. This review se …
Lastly, we provide an overview of existing rodent models of cholangiopathies and discuss their relevance to human disease. PSC remain …
Endocrine Disruptions in Thermal Injuries: Exploring Immune System Interactions.
Khalaf F, Wojtowicz-Piotrowski S, Ricciuti Z, Dadashizadeh G, Barayan D, Jeschke MG. Khalaf F, et al. Physiol Rev. 2026 Apr 13. doi: 10.1152/physrev.00035.2025. Online ahead of print. Physiol Rev. 2026. PMID: 41973596 Review.
Burn injuries are among the most devastating disruptors of human physiology, provoking systemic disturbances unmatched by nearly any other form of pathology, yet they remain critically underappreciated. ...A better understanding of the implications of burns on the endocrin …
Burn injuries are among the most devastating disruptors of human physiology, provoking systemic disturbances unmatched by nearly any …
Measuring autonomic influence on gastrointestinal contractility: development and preliminary validation of novel capsule-based indices.
Mehta M, Zhao Z, Erekat A, Semler J, Neupane N, Mueller BR, Coyle K, Cedillo G, Robinson-Papp J. Mehta M, et al. Am J Physiol Gastrointest Liver Physiol. 2026 Apr 13. doi: 10.1152/ajpgi.00006.2026. Online ahead of print. Am J Physiol Gastrointest Liver Physiol. 2026. PMID: 41973547
We analyzed WMC data from 98 controls and 71 people living with HIV (Human Immunodeficiency Virus; PWH) in whom autonomic neuropathy (AN) and delayed small bowel transit time (dSBTT) are common. ...
We analyzed WMC data from 98 controls and 71 people living with HIV (Human Immunodeficiency Virus; PWH) in whom autonomic neuropathy …
Navigating Medication Risk in the ED: Communication Preferences of Older Adults Regarding Deprescribing.
Burud G, Lopes E, Bhimani S, Goyal P, Niznik J, Donvan K, Dodson A, Musgrow K, Anton G, Hwang U, Meyer ML, Casey MF. Burud G, et al. Acad Emerg Med. 2026 Apr;33(4):e70287. doi: 10.1111/acem.70287. Acad Emerg Med. 2026. PMID: 41973408
We sought to explore patient communication preferences for deprescribing in the emergency department (ED) after an ADE. METHODS: We conducted a cross-sectional survey study of older adults aged 65 years and older presenting to a southeastern, academic ED from June 2024 to …
We sought to explore patient communication preferences for deprescribing in the emergency department (ED) after an ADE. METHODS: We c …
Age-related cognitive decline in house crickets reveals conserved patterns of sensory and learning deficits across the lifespan.
Liao GY, Klug J, Ladiges W. Liao GY, et al. Geroscience. 2026 Apr 13. doi: 10.1007/s11357-026-02245-4. Online ahead of print. Geroscience. 2026. PMID: 41973338
Olfactory decline was particularly pronounced in males, mirroring sex differences observed in human cognitive aging. House crickets exhibit hallmark features of cognitive aging, including sensory decline, learning impairments, and reduced resilience, independent of morphol …
Olfactory decline was particularly pronounced in males, mirroring sex differences observed in human cognitive aging. House crickets e …
Measurement Equivalence Across Sex, Race/Ethnicity, and Intersectional Identity for the Perceived Discrimination Scale Among Middle-School-Aged Black, Latinx, and White Youth: Findings From the Adolescent Brain Cognitive Development Study.
Sartor CE, Powell MZ, Kennelly N, Chung T, Latendresse SJ. Sartor CE, et al. J Racial Ethn Health Disparities. 2026 Apr 13. doi: 10.1007/s40615-026-02938-8. Online ahead of print. J Racial Ethn Health Disparities. 2026. PMID: 41973306
Endovascular Therapy for Post-Thrombotic Syndrome - A Randomized Trial.
Vedantham S, Kahn SR, Marston WA, Weinberg I, Sista AK, Magnuson EA, Cohen DJ, Wasan SM, Razavi MK, Goldhaber SZ, Sanfilippo KM, Comerota AJ, Azene EM, Chaar CIO, Leung DA, Kolli KP, Kalva SP, Rostambeigi N, Desai A, Desai KR, Tafur AJ, Khalsa B, Majerus E, Wang B, Wang Y, Nieters P, Derfler MC, Oliver A, Hardy C, Bashir R, Winokur R, Weger N, Khaja MS, Sharma A, Mani N, Kavali P, Thukral S, Lake LL, Mikkelsen K, Parpia S; C-TRACT Trial Investigators. Vedantham S, et al. N Engl J Med. 2026 Apr 13. doi: 10.1056/NEJMoa2519001. Online ahead of print. N Engl J Med. 2026. PMID: 41972998
CONCLUSIONS: Among patients with moderate or severe post-thrombotic syndrome and iliac-vein obstruction, endovascular therapy led to less severe post-thrombotic syndrome and better health-related quality of life than standard care over a 6-month period but with a higher ri …
CONCLUSIONS: Among patients with moderate or severe post-thrombotic syndrome and iliac-vein obstruction, endovascular therapy led to less se …
Grade C molar-incisor pattern periodontitis classification and its challenges.
Graças YTD, Miguel MMV, Casarin RCV, Santamaria MP, Mishra P, Shaddox LM. Graças YTD, et al. J Periodontol. 2026 Apr 13. doi: 10.1002/jper.70119. Online ahead of print. J Periodontol. 2026. PMID: 41972922 Review.
This review highlights key gaps in the grade C and molar-incisor pattern (C-MIP) classification, particularly the exclusion of primary dentition involvement, which limits early awareness, diagnosis, treatment, and research. Additionally, the current "grade C" category incl …
This review highlights key gaps in the grade C and molar-incisor pattern (C-MIP) classification, particularly the exclusion of primary denti …
The virus lesson: Teaching viral structure and quasi-symmetry in mixed reality.
Gardner A, Cannac F, Tallon Q, Olson A, Autin L. Gardner A, et al. Protein Sci. 2026 May;35(5):e70570. doi: 10.1002/pro.70570. Protein Sci. 2026. PMID: 41972840 Free PMC article.
Viral capsids, which employ quasi-symmetric arrangements, are especially difficult to conceptualize at the human scale. While physical models can illustrate geometry, they are costly, static, and disconnected from the digital domain. ...The Virus Lesson demonstrates that M …
Viral capsids, which employ quasi-symmetric arrangements, are especially difficult to conceptualize at the human scale. While physica …
Population-Based Associations of Body Mass Index and Treatments Received for Breast Cancer in a Rural, Midwestern State.
Blaess BL, Kahl AR, Lizarraga I, Schroeder MC, Robinson KM, Charlton ME, Nash SH. Blaess BL, et al. Cancer Med. 2026 Apr;15(4):e71831. doi: 10.1002/cam4.71831. Cancer Med. 2026. PMID: 41972811 Free PMC article.
DISCUSSION: These findings suggest breast cancer treatment differences exist for patients with higher BMI. Future research is warranted to understand mechanisms behind differences, both to ensure breast cancer patients with higher BMIs receive adequate and appropriate canc …
DISCUSSION: These findings suggest breast cancer treatment differences exist for patients with higher BMI. Future research is warrant …
Fixed-Bed Bioreactor Culture Enhances Yield and Reparative Properties of hTERT Mesenchymal Stem Cell Extracellular Vesicles.
Cuba Z, Godinho L, Choudhury S, Patil K, Williams A, Zhou W, Howard M, Aryal SP, Clayton KA, Routenberg DA, Liotta LA, Couch H, Kashanchi F, Branscome H. Cuba Z, et al. Cells. 2026 Apr 7;15(7):654. doi: 10.3390/cells15070654. Cells. 2026. PMID: 41972742 Free PMC article.
Although MSC-derived EVs have been widely investigated for their regenerative potential, progress toward translational evaluation has been limited in part by challenges in scalable and reproducible manufacturing. We recently reported that human telomerase reverse transcrip …
Although MSC-derived EVs have been widely investigated for their regenerative potential, progress toward translational evaluation has been l …
Peroxiredoxins in Stroke: Friends and Foes.
Wan Y, Zhang J, Bian L, Tan X, Chen T, Xi G, Hua Y, Pandey AS, Keep RF, Koduri S. Wan Y, et al. Cells. 2026 Apr 2;15(7):640. doi: 10.3390/cells15070640. Cells. 2026. PMID: 41972728 Free PMC article. Review.
Diagnostic and Therapeutic Applications of Exosomes in Lung Cancer.
Moholkar DN, Kandimalla R, Wallen M, Yaddanapudi K, Gupta R, Aqil F. Moholkar DN, et al. Cells. 2026 Mar 31;15(7):632. doi: 10.3390/cells15070632. Cells. 2026. PMID: 41972720 Free PMC article. Review.
However, clinical translation is hindered by challenges including lack of standardized isolation and characterization methods, high production costs, and regulatory uncertainties. Despite these limitations, ongoing research continues to optimize exosome production, targeti …
However, clinical translation is hindered by challenges including lack of standardized isolation and characterization methods, high producti …
Human Corneal Stromal Stem Cell Treatment Reduces Established Opacities in Chronic Corneal Scarring.
Lathrop KL, Coelho JT, Chandran C, Ali SR, Geary ML, Dhaliwal DK, Jhanji V, Santra M, Yam GHF. Lathrop KL, et al. Cells. 2026 Mar 30;15(7):615. doi: 10.3390/cells15070615. Cells. 2026. PMID: 41972705 Free PMC article.
Although corneal transplantation can restore vision, its effectiveness is constrained by limited accessibility, donor tissue shortages, and the risk of allograft rejection. Treatments with human corneal stromal stem cells (hCSSCs) have demonstrated scarless healing in prec …
Although corneal transplantation can restore vision, its effectiveness is constrained by limited accessibility, donor tissue shortages, and …
The Genotoxic Stress Sensor ZBP1 Drives Tau Pathology.
Thanos JM, Campbell OC, Natale NR, Royo Marco A, Puchalski MA, Lukens JR. Thanos JM, et al. Cells. 2026 Mar 26;15(7):591. doi: 10.3390/cells15070591. Cells. 2026. PMID: 41972681 Free PMC article.
Human Ghrelin Improves Vascular Integrity and Survival After Total Body Irradiation.
Chaung W, Jacob A, Wang Z, Yang WL, Brenner M, Wang P. Chaung W, et al. Cells. 2026 Mar 26;15(7):586. doi: 10.3390/cells15070586. Cells. 2026. PMID: 41972677 Free PMC article.
Subsequently, human ghrelin treatment showed an effective dose modification factor of 1.0681. On day 4 after TBI, human ghrelin significantly attenuated EC permeability in the lungs and improved tight junction protein ZO-1 expression. Human ghrelin also impro …
Subsequently, human ghrelin treatment showed an effective dose modification factor of 1.0681. On day 4 after TBI, human ghreli …
Highlights of Tuft Cells in Mouse and Human Salivary Glands.
Rusiniak ME, Shimagami L, Drumond VZ, Souza MS, Castro FLAL, Xue C, Zhang M, Qu J, Chlipala GE, Maienschein-Cline M, Silva TAD, Sousa SF, Dos Santos HT. Rusiniak ME, et al. Cells. 2026 Mar 25;15(7):583. doi: 10.3390/cells15070583. Cells. 2026. PMID: 41972672 Free PMC article.
This study aimed to define TC structure in mice submandibular glands (SMGs), determine how TC loss affects gland organization and function, and evaluate whether TC abundance in human minor SGs is associated with Sjogren's disease (SjD) features. Specifically, TC ultrastruc …
This study aimed to define TC structure in mice submandibular glands (SMGs), determine how TC loss affects gland organization and function, …
Modulation of miRNA Signature in Human Adipose Tissue After 3 Months of omega-3PUFA Supplementation.
Hernandez J, Lee M, Cochran M, Li T, Wang P, Coletta DK, Rau C, Dinu V, De Filippis E. Hernandez J, et al. Cells. 2026 Mar 25;15(7):577. doi: 10.3390/cells15070577. Cells. 2026. PMID: 41972668 Free PMC article.
Obesity is a persistent public health issue, often resulting in metabolic complications such as insulin resistance (IR). ...Our study reports the modulation of miRNA in AT, reductions in systemic and AT markers of inflammation, and the improvement of IR post omega-3PUFA su …
Obesity is a persistent public health issue, often resulting in metabolic complications such as insulin resistance (IR). ...Our study …
Human Cytomegalovirus as a Therapeutic Target in Glioma Stem Cells.
Bou Dargham T, Vaios EJ, Lawler S, Batich K. Bou Dargham T, et al. Cells. 2026 Mar 24;15(7):575. doi: 10.3390/cells15070575. Cells. 2026. PMID: 41972666 Free PMC article. Review.
Therapeutic strategies using herpesviruses have been evaluated following the discovery of differential human cytomegalovirus (HCMV) expression in glioblastoma tumor cells. The absence of expression in normal brain tissue led to multiple clinical trials demonstrating the po …
Therapeutic strategies using herpesviruses have been evaluated following the discovery of differential human cytomegalovirus (HCMV) e …
VEGFR Blockade Reduces Mycobacterium tuberculosis-Induced Lung Pathology in Immunocompromised Mice.
Herbath M, Harding J, Priyathilaka TT, Laaker CJ, Kafkas A, Fabry Z, Sandor M. Herbath M, et al. Cells. 2026 Mar 24;15(7):573. doi: 10.3390/cells15070573. Cells. 2026. PMID: 41972664 Free PMC article.
Mycobacterium tuberculosis (Mtb) remains a significant public health threat, responsible for 1.6 million deaths in 2021. The development of new treatments is particularly urgent for immunocompromised individuals, including those with Mtb/HIV coinfection, who experience sev …
Mycobacterium tuberculosis (Mtb) remains a significant public health threat, responsible for 1.6 million deaths in 2021. The developm …
Spleen Tyrosine Kinase (SYK) is Necessary for cGAS-STING Signaling in Müller Glia and Visual Function Deficits in Diabetic Mice.
Yerlikaya EI, Sunilkumar S, Subrahmanian SM, Toro AL, Yeager CT, Shaikh KA, Harhaj EW, Barber AJ, Dennis MD. Yerlikaya EI, et al. Glia. 2026 Jun;74(6):e70155. doi: 10.1002/glia.70155. Glia. 2026. PMID: 41972434 Free PMC article.
Hyperglycemic culture conditions increased mitochondrial membrane permeability and cytosolic mitochondrial DNA content in human MIO-M1 Muller cells and enhanced cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling, nuclear factor-kappaB (NF-kappa …
Hyperglycemic culture conditions increased mitochondrial membrane permeability and cytosolic mitochondrial DNA content in human MIO-M …
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone.
Schurman CA, Kaur G, Kaya S, Bons J, Aguirre CG, Liu Q, King CD, Wilson KA, Baker HL, Hady M, Luna NM, Bieri G, Villeda SA, Ellerby LM, Schilling B, Alliston T. Schurman CA, et al. Adv Sci (Weinh). 2026 Apr 13:e23511. doi: 10.1002/advs.202523511. Online ahead of print. Adv Sci (Weinh). 2026. PMID: 41972397
Apoe localized specifically to osteocytes, with expression in aged female bone nearly twice that of young 4-month-old male bone. Because human APOE alleles confer different age-related AD risks, we examined their roles in bone using humanized APOE2, APOE3, and APOE4 knock- …
Apoe localized specifically to osteocytes, with expression in aged female bone nearly twice that of young 4-month-old male bone. Because …
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