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Page 1
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.
Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ, Laplant Q, Graham A, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga CA, Cooper DC, Gershenfeld HK, Nestler EJ. Krishnan V, et al. Among authors: han mh. Cell. 2007 Oct 19;131(2):391-404. doi: 10.1016/j.cell.2007.09.018. Cell. 2007. PMID: 17956738 Free article.
AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli.
Krishnan V, Han MH, Mazei-Robison M, Iñiguez SD, Ables JL, Vialou V, Berton O, Ghose S, Covington HE 3rd, Wiley MD, Henderson RP, Neve RL, Eisch AJ, Tamminga CA, Russo SJ, Bolaños CA, Nestler EJ. Krishnan V, et al. Among authors: han mh. Biol Psychiatry. 2008 Oct 15;64(8):691-700. doi: 10.1016/j.biopsych.2008.06.003. Epub 2008 Jul 18. Biol Psychiatry. 2008. PMID: 18639865 Free PMC article.
CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits.
Wallace DL, Han MH, Graham DL, Green TA, Vialou V, Iñiguez SD, Cao JL, Kirk A, Chakravarty S, Kumar A, Krishnan V, Neve RL, Cooper DC, Bolaños CA, Barrot M, McClung CA, Nestler EJ. Wallace DL, et al. Among authors: han mh. Nat Neurosci. 2009 Feb;12(2):200-9. doi: 10.1038/nn.2257. Epub 2009 Jan 18. Nat Neurosci. 2009. PMID: 19151710 Free PMC article.
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward.
Lobo MK, Covington HE 3rd, Chaudhury D, Friedman AK, Sun H, Damez-Werno D, Dietz DM, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ. Lobo MK, et al. Among authors: han mh. Science. 2010 Oct 15;330(6002):385-90. doi: 10.1126/science.1188472. Science. 2010. PMID: 20947769 Free PMC article.
IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity.
Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, Kim Y, Morrison JH, Russo SJ. Christoffel DJ, et al. Among authors: han mh. J Neurosci. 2011 Jan 5;31(1):314-21. doi: 10.1523/JNEUROSCI.4763-10.2011. J Neurosci. 2011. PMID: 21209217 Free PMC article.
Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine.
Choi KH, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman AK, Walsh JJ, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han MH, Self DW. Choi KH, et al. Among authors: han mh. J Neurosci. 2011 May 25;31(21):7927-37. doi: 10.1523/JNEUROSCI.6014-10.2011. J Neurosci. 2011. PMID: 21613507 Free PMC article.
Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons.
Mazei-Robison MS, Koo JW, Friedman AK, Lansink CS, Robison AJ, Vinish M, Krishnan V, Kim S, Siuta MA, Galli A, Niswender KD, Appasani R, Horvath MC, Neve RL, Worley PF, Snyder SH, Hurd YL, Cheer JF, Han MH, Russo SJ, Nestler EJ. Mazei-Robison MS, et al. Among authors: han mh. Neuron. 2011 Dec 22;72(6):977-90. doi: 10.1016/j.neuron.2011.10.012. Neuron. 2011. PMID: 22196333 Free PMC article.
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J. Kurita M, et al. Among authors: han mh. Nat Neurosci. 2012 Sep;15(9):1245-54. doi: 10.1038/nn.3181. Epub 2012 Aug 5. Nat Neurosci. 2012. PMID: 22864611 Free PMC article.
BDNF is a negative modulator of morphine action.
Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han MH, Nestler EJ. Koo JW, et al. Among authors: han mh. Science. 2012 Oct 5;338(6103):124-8. doi: 10.1126/science.1222265. Science. 2012. PMID: 23042896 Free PMC article.
Neurobiology of resilience.
Russo SJ, Murrough JW, Han MH, Charney DS, Nestler EJ. Russo SJ, et al. Among authors: han mh. Nat Neurosci. 2012 Nov;15(11):1475-84. doi: 10.1038/nn.3234. Epub 2012 Oct 14. Nat Neurosci. 2012. PMID: 23064380 Free PMC article. Review.
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons.
Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Mazei-Robison MS, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH. Chaudhury D, et al. Among authors: han mh. Nature. 2013 Jan 24;493(7433):532-6. doi: 10.1038/nature11713. Epub 2012 Dec 12. Nature. 2013. PMID: 23235832 Free PMC article.
ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli.
Lobo MK, Zaman S, Damez-Werno DM, Koo JW, Bagot RC, DiNieri JA, Nugent A, Finkel E, Chaudhury D, Chandra R, Riberio E, Rabkin J, Mouzon E, Cachope R, Cheer JF, Han MH, Dietz DM, Self DW, Hurd YL, Vialou V, Nestler EJ. Lobo MK, et al. Among authors: han mh. J Neurosci. 2013 Nov 20;33(47):18381-95. doi: 10.1523/JNEUROSCI.1875-13.2013. J Neurosci. 2013. PMID: 24259563 Free PMC article.
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway.
Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B, Burnham VL, Mazei-Robison MS, Ferguson D, Golden SA, Koo JW, Chaudhury D, Christoffel DJ, Pomeranz L, Friedman JM, Russo SJ, Nestler EJ, Han MH. Walsh JJ, et al. Among authors: han mh. Nat Neurosci. 2014 Jan;17(1):27-9. doi: 10.1038/nn.3591. Epub 2013 Nov 24. Nat Neurosci. 2014. PMID: 24270188 Free PMC article.
G9a influences neuronal subtype specification in striatum.
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ. Maze I, et al. Among authors: han mh. Nat Neurosci. 2014 Apr;17(4):533-9. doi: 10.1038/nn.3670. Epub 2014 Mar 2. Nat Neurosci. 2014. PMID: 24584053 Free PMC article.
Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors.
Heller EA, Cates HM, Peña CJ, Sun H, Shao N, Feng J, Golden SA, Herman JP, Walsh JJ, Mazei-Robison M, Ferguson D, Knight S, Gerber MA, Nievera C, Han MH, Russo SJ, Tamminga CS, Neve RL, Shen L, Zhang HS, Zhang F, Nestler EJ. Heller EA, et al. Among authors: han mh. Nat Neurosci. 2014 Dec;17(12):1720-7. doi: 10.1038/nn.3871. Epub 2014 Oct 27. Nat Neurosci. 2014. PMID: 25347353 Free PMC article.
Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress.
Christoffel DJ, Golden SA, Walsh JJ, Guise KG, Heshmati M, Friedman AK, Dey A, Smith M, Rebusi N, Pfau M, Ables JL, Aleyasin H, Khibnik LA, Hodes GE, Ben-Dor GA, Deisseroth K, Shapiro ML, Malenka RC, Ibanez-Tallon I, Han MH, Russo SJ. Christoffel DJ, et al. Among authors: han mh. Nat Neurosci. 2015 Jul;18(7):962-4. doi: 10.1038/nn.4034. Epub 2015 Jun 1. Nat Neurosci. 2015. PMID: 26030846 Free PMC article.
The Use of Herpes Simplex Virus in Ex Vivo Slice Culture.
Friedman AK, Han MH. Friedman AK, et al. Among authors: han mh. Curr Protoc Neurosci. 2015 Jul 1;72:4.36.1-4.36.7. doi: 10.1002/0471142301.ns0436s72. Curr Protoc Neurosci. 2015. PMID: 26131662 Free PMC article.
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism.
Friedman AK, Juarez B, Ku SM, Zhang H, Calizo RC, Walsh JJ, Chaudhury D, Zhang S, Hawkins A, Dietz DM, Murrough JW, Ribadeneira M, Wong EH, Neve RL, Han MH. Friedman AK, et al. Among authors: han mh. Nat Commun. 2016 May 24;7:11671. doi: 10.1038/ncomms11671. Nat Commun. 2016. PMID: 27216573 Free PMC article.
Basal forebrain projections to the lateral habenula modulate aggression reward.
Golden SA, Heshmati M, Flanigan M, Christoffel DJ, Guise K, Pfau ML, Aleyasin H, Menard C, Zhang H, Hodes GE, Bregman D, Khibnik L, Tai J, Rebusi N, Krawitz B, Chaudhury D, Walsh JJ, Han MH, Shapiro ML, Russo SJ. Golden SA, et al. Among authors: han mh. Nature. 2016 Jun 30;534(7609):688-92. doi: 10.1038/nature18601. Nature. 2016. PMID: 27357796 Free PMC article.
Dopaminergic dynamics underlying sex-specific cocaine reward.
Calipari ES, Juarez B, Morel C, Walker DM, Cahill ME, Ribeiro E, Roman-Ortiz C, Ramakrishnan C, Deisseroth K, Han MH, Nestler EJ. Calipari ES, et al. Among authors: han mh. Nat Commun. 2017 Jan 10;8:13877. doi: 10.1038/ncomms13877. Nat Commun. 2017. PMID: 28072417 Free PMC article.
Brain-Derived Neurotrophic Factor in the Mesolimbic Reward Circuitry Mediates Nociception in Chronic Neuropathic Pain.
Zhang H, Qian YL, Li C, Liu D, Wang L, Wang XY, Liu MJ, Liu H, Zhang S, Guo XY, Yang JX, Ding HL, Koo JW, Mouzon E, Deisseroth K, Nestler EJ, Zachariou V, Han MH, Cao JL. Zhang H, et al. Among authors: han mh. Biol Psychiatry. 2017 Oct 15;82(8):608-618. doi: 10.1016/j.biopsych.2017.02.1180. Epub 2017 Mar 1. Biol Psychiatry. 2017. PMID: 28390647 Free PMC article.
Neural Substrates of Depression and Resilience.
Han MH, Nestler EJ. Han MH, et al. Neurotherapeutics. 2017 Jul;14(3):677-686. doi: 10.1007/s13311-017-0527-x. Neurotherapeutics. 2017. PMID: 28397115 Free PMC article. Review.
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.
Lopez JP, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C, Han MH, Foster J, Frey BN, Soares CN, Müller DJ, Farzan F, Leri F, MacQueen GM, Feilotter H, Tyryshkin K, Evans KR, Giacobbe P, Blier P, Lam RW, Milev R, Parikh SV, Rotzinger S, Strother SC, Lewis CM, Aitchison KJ, Wittenberg GM, Mechawar N, Nestler EJ, Uher R, Kennedy SH, Turecki G. Lopez JP, et al. Among authors: han mh. Nat Commun. 2017 May 22;8:15497. doi: 10.1038/ncomms15497. Nat Commun. 2017. PMID: 28530238 Free PMC article. Clinical Trial.
Establishment of a repeated social defeat stress model in female mice.
Takahashi A, Chung JR, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan ME, Pfau ML, Menard C, Dumitriu D, Hodes GE, McEwen BS, Nestler EJ, Han MH, Russo SJ. Takahashi A, et al. Among authors: han mh. Sci Rep. 2017 Oct 9;7(1):12838. doi: 10.1038/s41598-017-12811-8. Sci Rep. 2017. PMID: 28993631 Free PMC article.
Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior.
Guzman D, Carreira MB, Friedman AK, Adachi M, Neve RL, Monteggia LM, Han MH, Cowan CW, Self DW. Guzman D, et al. Among authors: han mh. J Neurosci. 2018 Jan 17;38(3):575-585. doi: 10.1523/JNEUROSCI.2828-16.2017. Epub 2017 Dec 1. J Neurosci. 2018. PMID: 29196318 Free PMC article.
Midbrain circuit regulation of individual alcohol drinking behaviors in mice.
Juarez B, Morel C, Ku SM, Liu Y, Zhang H, Montgomery S, Gregoire H, Ribeiro E, Crumiller M, Roman-Ortiz C, Walsh JJ, Jackson K, Croote DE, Zhu Y, Zhang S, Vendruscolo LF, Edwards S, Roberts A, Hodes GE, Lu Y, Calipari ES, Chaudhury D, Friedman AK, Han MH. Juarez B, et al. Among authors: han mh. Nat Commun. 2017 Dec 20;8(1):2220. doi: 10.1038/s41467-017-02365-8. Nat Commun. 2017. PMID: 29263389 Free PMC article.
Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice.
Juarez B, Morel C, Ku SM, Liu Y, Zhang H, Montgomery S, Gregoire H, Ribeiro E, Crumiller M, Roman-Ortiz C, Walsh JJ, Jackson K, Croote DE, Zhu Y, Zhang S, Vendruscolo LF, Edwards S, Roberts A, Hodes GE, Lu Y, Calipari ES, Chaudhury D, Friedman AK, Han MH. Juarez B, et al. Among authors: han mh. Nat Commun. 2018 Feb 8;9(1):653. doi: 10.1038/s41467-018-02921-w. Nat Commun. 2018. PMID: 29422549 Free PMC article.
Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine.
Ribeiro EA, Salery M, Scarpa JR, Calipari ES, Hamilton PJ, Ku SM, Kronman H, Purushothaman I, Juarez B, Heshmati M, Doyle M, Lardner C, Burek D, Strat A, Pirpinias S, Mouzon E, Han MH, Neve RL, Bagot RC, Kasarskis A, Koo JW, Nestler EJ. Ribeiro EA, et al. Among authors: han mh. Nat Commun. 2018 Aug 8;9(1):3149. doi: 10.1038/s41467-018-05657-9. Nat Commun. 2018. PMID: 30089879 Free PMC article.
α1- and β3-Adrenergic Receptor-Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice.
Zhang H, Chaudhury D, Nectow AR, Friedman AK, Zhang S, Juarez B, Liu H, Pfau ML, Aleyasin H, Jiang C, Crumiller M, Calipari ES, Ku SM, Morel C, Tzavaras N, Montgomery SE, He M, Salton SR, Russo SJ, Nestler EJ, Friedman JM, Cao JL, Han MH. Zhang H, et al. Among authors: han mh. Biol Psychiatry. 2019 Feb 1;85(3):226-236. doi: 10.1016/j.biopsych.2018.08.020. Epub 2018 Sep 6. Biol Psychiatry. 2019. PMID: 30336931 Free PMC article.
Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder.
Tan A, Costi S, Morris LS, Van Dam NT, Kautz M, Whitton AE, Friedman AK, Collins KA, Ahle G, Chadha N, Do B, Pizzagalli DA, Iosifescu DV, Nestler EJ, Han MH, Murrough JW. Tan A, et al. Among authors: han mh. Mol Psychiatry. 2020 Jun;25(6):1323-1333. doi: 10.1038/s41380-018-0283-2. Epub 2018 Nov 1. Mol Psychiatry. 2020. PMID: 30385872 Free PMC article. Clinical Trial.
Neurobiology of Resilience: Interface Between Mind and Body.
Cathomas F, Murrough JW, Nestler EJ, Han MH, Russo SJ. Cathomas F, et al. Among authors: han mh. Biol Psychiatry. 2019 Sep 15;86(6):410-420. doi: 10.1016/j.biopsych.2019.04.011. Epub 2019 Apr 17. Biol Psychiatry. 2019. PMID: 31178098 Free PMC article. Review.
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression.
Koo JW, Chaudhury D, Han MH, Nestler EJ. Koo JW, et al. Among authors: han mh. Biol Psychiatry. 2019 Nov 15;86(10):738-748. doi: 10.1016/j.biopsych.2019.05.020. Epub 2019 Jun 4. Biol Psychiatry. 2019. PMID: 31327473 Free PMC article. Review.
846 results