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Page 1
GLPG2737 in lumacaftor/ivacaftor-treated CF subjects homozygous for the F508del mutation: A randomized phase 2A trial (PELICAN).
van Koningsbruggen-Rietschel S, Conrath K, Fischer R, Sutharsan S, Kempa A, Gleiber W, Schwarz C, Hector A, Van Osselaer N, Pano A, Corveleyn S, Bwirire D, Santermans E, Muller K, Bellaire S, Van de Steen O. van Koningsbruggen-Rietschel S, et al. Among authors: hector a. J Cyst Fibros. 2020 Mar;19(2):292-298. doi: 10.1016/j.jcf.2019.09.006. Epub 2019 Oct 5. J Cyst Fibros. 2020. PMID: 31594690 Free article. Clinical Trial.
Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Inhalation treatment with glutathione in patients with cystic fibrosis. A randomized clinical trial.
Griese M, Kappler M, Eismann C, Ballmann M, Junge S, Rietschel E, van Koningsbruggen-Rietschel S, Staab D, Rolinck-Werninghaus C, Mellies U, Köhnlein T, Wagner T, König S, Teschler H, Heuer HE, Kopp M, Heyder S, Hammermann J, Küster P, Honer M, Mansmann U, Beck-Speier I, Hartl D, Fuchs C; Glutathione Study Group; Hector A. Griese M, et al. Among authors: hector a. Am J Respir Crit Care Med. 2013 Jul 1;188(1):83-9. doi: 10.1164/rccm.201303-0427OC. Am J Respir Crit Care Med. 2013. PMID: 23631796 Clinical Trial.
Fungal Pathogens in CF Airways: Leave or Treat?
Singh A, Ralhan A, Schwarz C, Hartl D, Hector A. Singh A, et al. Among authors: hector a. Mycopathologia. 2018 Feb;183(1):119-137. doi: 10.1007/s11046-017-0184-y. Epub 2017 Aug 2. Mycopathologia. 2018. PMID: 28770417 Review.
Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele.
Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group. Middleton PG, et al. N Engl J Med. 2019 Nov 7;381(19):1809-1819. doi: 10.1056/NEJMoa1908639. Epub 2019 Oct 31. N Engl J Med. 2019. PMID: 31697873 Free PMC article. Clinical Trial.
Cystic fibrosis related diabetes is not associated with maximal aerobic exercise capacity in cystic fibrosis: a cross-sectional analysis of an international multicenter trial.
Radtke T, Kriemler S, Stein L, Karila C, Urquhart DS, Orenstein DM, Lands LC, Schindler C, Eber E, Haile SR, Hebestreit H; ACTIVATE-CF Study Working Group. Radtke T, et al. J Cyst Fibros. 2023 Jan;22(1):31-38. doi: 10.1016/j.jcf.2022.06.012. Epub 2022 Jul 6. J Cyst Fibros. 2023. PMID: 35803884
Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF).
Hebestreit H, Kriemler S, Schindler C, Stein L, Karila C, Urquhart DS, Orenstein DM, Lands LC, Schaeff J, Eber E, Radtke T; ACTIVATE-CF Study Working Group. Hebestreit H, et al. Am J Respir Crit Care Med. 2022 Feb 1;205(3):330-339. doi: 10.1164/rccm.202106-1419OC. Am J Respir Crit Care Med. 2022. PMID: 34735776 Free PMC article. Clinical Trial.
Microbial colonization and lung function in adolescents with cystic fibrosis.
Hector A, Kirn T, Ralhan A, Graepler-Mainka U, Berenbrinker S, Riethmueller J, Hogardt M, Wagner M, Pfleger A, Autenrieth I, Kappler M, Griese M, Eber E, Martus P, Hartl D. Hector A, et al. J Cyst Fibros. 2016 May;15(3):340-9. doi: 10.1016/j.jcf.2016.01.004. Epub 2016 Feb 5. J Cyst Fibros. 2016. PMID: 26856310 Free article.
Innate immunity in cystic fibrosis lung disease.
Hartl D, Gaggar A, Bruscia E, Hector A, Marcos V, Jung A, Greene C, McElvaney G, Mall M, Döring G. Hartl D, et al. Among authors: hector a. J Cyst Fibros. 2012 Sep;11(5):363-82. doi: 10.1016/j.jcf.2012.07.003. Epub 2012 Aug 20. J Cyst Fibros. 2012. PMID: 22917571 Free article. Review.
Regulatory T-cell impairment in cystic fibrosis patients with chronic pseudomonas infection.
Hector A, Schäfer H, Pöschel S, Fischer A, Fritzsching B, Ralhan A, Carevic M, Öz H, Zundel S, Hogardt M, Bakele M, Rieber N, Riethmueller J, Graepler-Mainka U, Stahl M, Bender A, Frick JS, Mall M, Hartl D. Hector A, et al. Am J Respir Crit Care Med. 2015 Apr 15;191(8):914-23. doi: 10.1164/rccm.201407-1381OC. Am J Respir Crit Care Med. 2015. PMID: 25632992
Current concepts of immune dysregulation in cystic fibrosis.
Rieber N, Hector A, Carevic M, Hartl D. Rieber N, et al. Among authors: hector a. Int J Biochem Cell Biol. 2014 Jul;52:108-12. doi: 10.1016/j.biocel.2014.01.017. Epub 2014 Feb 2. Int J Biochem Cell Biol. 2014. PMID: 24495876 Review.
Therapy of CF-patients with amitriptyline and placebo--a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-study.
Nährlich L, Mainz JG, Adams C, Engel C, Herrmann G, Icheva V, Lauer J, Deppisch C, Wirth A, Unger K, Graepler-Mainka U, Hector A, Heyder S, Stern M, Döring G, Gulbins E, Riethmüller J. Nährlich L, et al. Among authors: hector a. Cell Physiol Biochem. 2013;31(4-5):505-12. doi: 10.1159/000350071. Epub 2013 Apr 2. Cell Physiol Biochem. 2013. PMID: 23572075 Free article. Clinical Trial.
The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease.
Hector A, Kormann MS, Mack I, Latzin P, Casaulta C, Kieninger E, Zhou Z, Yildirim AÖ, Bohla A, Rieber N, Kappler M, Koller B, Eber E, Eickmeier O, Zielen S, Eickelberg O, Griese M, Mall MA, Hartl D. Hector A, et al. PLoS One. 2011;6(9):e24399. doi: 10.1371/journal.pone.0024399. Epub 2011 Sep 20. PLoS One. 2011. PMID: 21949714 Free PMC article.
Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy.
Manzenreiter R, Kienberger F, Marcos V, Schilcher K, Krautgartner WD, Obermayer A, Huml M, Stoiber W, Hector A, Griese M, Hannig M, Studnicka M, Vitkov L, Hartl D. Manzenreiter R, et al. Among authors: hector a. J Cyst Fibros. 2012 Mar;11(2):84-92. doi: 10.1016/j.jcf.2011.09.008. Epub 2011 Oct 12. J Cyst Fibros. 2012. PMID: 21996135 Free article.
CXCR4+ granulocytes reflect fungal cystic fibrosis lung disease.
Carevic M, Singh A, Rieber N, Eickmeier O, Griese M, Hector A, Hartl D. Carevic M, et al. Among authors: hector a. Eur Respir J. 2015 Aug;46(2):395-404. doi: 10.1183/09031936.00173514. Epub 2015 Apr 30. Eur Respir J. 2015. PMID: 25929952 Free article.
The role of matrix metalloproteinases in cystic fibrosis lung disease.
Gaggar A, Hector A, Bratcher PE, Mall MA, Griese M, Hartl D. Gaggar A, et al. Among authors: hector a. Eur Respir J. 2011 Sep;38(3):721-7. doi: 10.1183/09031936.00173210. Epub 2011 Jan 13. Eur Respir J. 2011. PMID: 21233269 Free PMC article. Review.
Expression and regulation of interferon-related development regulator-1 in cystic fibrosis neutrophils.
Hector A, Kormann M, Kammermeier J, Burdi S, Marcos V, Rieber N, Mays L, Illig T, Klopp N, Falkenstein F, Kappler M, Riethmueller J, Graepler-Mainka U, Stern M, Eickmeier O, Serve F, Zielen S, Döring G, Griese M, Hartl D. Hector A, et al. Am J Respir Cell Mol Biol. 2013 Jan;48(1):71-7. doi: 10.1165/rcmb.2012-0061OC. Epub 2012 Oct 4. Am J Respir Cell Mol Biol. 2013. PMID: 23043087
Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease.
Rieber N, Brand A, Hector A, Graepler-Mainka U, Ost M, Schäfer I, Wecker I, Neri D, Wirth A, Mays L, Zundel S, Fuchs J, Handgretinger R, Stern M, Hogardt M, Döring G, Riethmüller J, Kormann M, Hartl D. Rieber N, et al. Among authors: hector a. J Immunol. 2013 Feb 1;190(3):1276-84. doi: 10.4049/jimmunol.1202144. Epub 2012 Dec 31. J Immunol. 2013. PMID: 23277486
Free DNA in cystic fibrosis airway fluids correlates with airflow obstruction.
Marcos V, Zhou-Suckow Z, Önder Yildirim A, Bohla A, Hector A, Vitkov L, Krautgartner WD, Stoiber W, Griese M, Eickelberg O, Mall MA, Hartl D. Marcos V, et al. Among authors: hector a. Mediators Inflamm. 2015;2015:408935. doi: 10.1155/2015/408935. Epub 2015 Mar 31. Mediators Inflamm. 2015. PMID: 25918476 Free PMC article.
Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses.
Rieber N, Gille C, Köstlin N, Schäfer I, Spring B, Ost M, Spieles H, Kugel HA, Pfeiffer M, Heininger V, Alkhaled M, Hector A, Mays L, Kormann M, Zundel S, Fuchs J, Handgretinger R, Poets CF, Hartl D. Rieber N, et al. Among authors: hector a. Clin Exp Immunol. 2013 Oct;174(1):45-52. doi: 10.1111/cei.12143. Clin Exp Immunol. 2013. PMID: 23701226 Free PMC article.
CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation.
Marcos V, Zhou Z, Yildirim AO, Bohla A, Hector A, Vitkov L, Wiedenbauer EM, Krautgartner WD, Stoiber W, Belohradsky BH, Rieber N, Kormann M, Koller B, Roscher A, Roos D, Griese M, Eickelberg O, Döring G, Mall MA, Hartl D. Marcos V, et al. Among authors: hector a. Nat Med. 2010 Sep;16(9):1018-23. doi: 10.1038/nm.2209. Epub 2010 Sep 5. Nat Med. 2010. PMID: 20818377 Retracted.
Chitinase activation in patients with fungus-associated cystic fibrosis lung disease.
Hector A, Chotirmall SH, Lavelle GM, Mirković B, Horan D, Eichler L, Mezger M, Singh A, Ralhan A, Berenbrinker S, Mack I, Ensenauer R, Riethmüller J, Graepler-Mainka U, Murray MA, Griese M, McElvaney NG, Hartl D. Hector A, et al. J Allergy Clin Immunol. 2016 Oct;138(4):1183-1189.e4. doi: 10.1016/j.jaci.2016.01.031. Epub 2016 Apr 4. J Allergy Clin Immunol. 2016. PMID: 27056270
CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense.
Carevic M, Öz H, Fuchs K, Laval J, Schroth C, Frey N, Hector A, Bilich T, Haug M, Schmidt A, Autenrieth SE, Bucher K, Beer-Hammer S, Gaggar A, Kneilling M, Benarafa C, Gao JL, Murphy PM, Schwarz S, Moepps B, Hartl D. Carevic M, et al. Among authors: hector a. J Innate Immun. 2016;8(4):362-73. doi: 10.1159/000444125. Epub 2016 Mar 8. J Innate Immun. 2016. PMID: 26950764 Free PMC article.
Localization and functionality of the inflammasome in neutrophils.
Bakele M, Joos M, Burdi S, Allgaier N, Pöschel S, Fehrenbacher B, Schaller M, Marcos V, Kümmerle-Deschner J, Rieber N, Borregaard N, Yazdi A, Hector A, Hartl D. Bakele M, et al. Among authors: hector a. J Biol Chem. 2014 Feb 21;289(8):5320-9. doi: 10.1074/jbc.M113.505636. Epub 2014 Jan 7. J Biol Chem. 2014. PMID: 24398679 Free PMC article.
296 results