Holt JR - Search Results

1

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B.

Lee J, Nist-Lund C, Solanes P, Goldberg H, Wu J, Pan B, Schneider BL, Holt JR. Lee J, et al. Among authors: holt jr. Hear Res. 2020 Sep 1;394:107882. doi: 10.1016/j.heares.2020.107882. Epub 2020 Jan 13. Hear Res. 2020. PMID: 31980281 Free article.

2

Mechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ.

Holt JR, Corey DP, Eatock RA. Holt JR, et al. J Neurosci. 1997 Nov 15;17(22):8739-48. doi: 10.1523/JNEUROSCI.17-22-08739.1997. J Neurosci. 1997. PMID: 9348343 Free PMC article.

3

Stimulus processing by type II hair cells in the mouse utricle.

Holt JR, Vollrath MA, Eatock RA. Holt JR, et al. Ann N Y Acad Sci. 1999 May 28;871:15-26. doi: 10.1111/j.1749-6632.1999.tb09172.x. Ann N Y Acad Sci. 1999. PMID: 10372060

4

TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.

Pan B, Géléoc GS, Asai Y, Horwitz GC, Kurima K, Ishikawa K, Kawashima Y, Griffith AJ, Holt JR. Pan B, et al. Among authors: holt jr. Neuron. 2013 Aug 7;79(3):504-15. doi: 10.1016/j.neuron.2013.06.019. Epub 2013 Jul 18. Neuron. 2013. PMID: 23871232 Free PMC article.

5

Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.

Zou J, Zheng T, Ren C, Askew C, Liu XP, Pan B, Holt JR, Wang Y, Yang J. Zou J, et al. Among authors: holt jr. Hum Mol Genet. 2014 May 1;23(9):2374-90. doi: 10.1093/hmg/ddt629. Epub 2013 Dec 11. Hum Mol Genet. 2014. PMID: 24334608 Free PMC article.

6

TMC function in hair cell transduction.

Holt JR, Pan B, Koussa MA, Asai Y. Holt JR, et al. Hear Res. 2014 May;311:17-24. doi: 10.1016/j.heares.2014.01.001. Epub 2014 Jan 11. Hear Res. 2014. PMID: 24423408 Free PMC article. Review.

7

Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation.

Kawashima Y, Kurima K, Pan B, Griffith AJ, Holt JR. Kawashima Y, et al. Among authors: holt jr. Pflugers Arch. 2015 Jan;467(1):85-94. doi: 10.1007/s00424-014-1582-3. Epub 2014 Jul 31. Pflugers Arch. 2015. PMID: 25074487 Free PMC article. Review.

8

Tmc gene therapy restores auditory function in deaf mice.

Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Askew C, et al. Among authors: holt jr. Sci Transl Med. 2015 Jul 8;7(295):295ra108. doi: 10.1126/scitranslmed.aab1996. Sci Transl Med. 2015. PMID: 26157030 Free PMC article.

9

The molecules that mediate sensory transduction in the mammalian inner ear.

Pan B, Holt JR. Pan B, et al. Among authors: holt jr. Curr Opin Neurobiol. 2015 Oct;34:165-71. doi: 10.1016/j.conb.2015.06.013. Epub 2015 Jul 25. Curr Opin Neurobiol. 2015. PMID: 26218316 Free PMC article. Review.

10

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia.

Kurima K, Ebrahim S, Pan B, Sedlacek M, Sengupta P, Millis BA, Cui R, Nakanishi H, Fujikawa T, Kawashima Y, Choi BY, Monahan K, Holt JR, Griffith AJ, Kachar B. Kurima K, et al. Among authors: holt jr. Cell Rep. 2015 Sep 8;12(10):1606-17. doi: 10.1016/j.celrep.2015.07.058. Epub 2015 Aug 28. Cell Rep. 2015. PMID: 26321635 Free PMC article.

11

RNA Interference Prevents Autosomal-Dominant Hearing Loss.

Shibata SB, Ranum PT, Moteki H, Pan B, Goodwin AT, Goodman SS, Abbas PJ, Holt JR, Smith RJH. Shibata SB, et al. Among authors: holt jr. Am J Hum Genet. 2016 Jun 2;98(6):1101-1113. doi: 10.1016/j.ajhg.2016.03.028. Epub 2016 May 26. Am J Hum Genet. 2016. PMID: 27236922 Free PMC article.

12

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear.

Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH. Landegger LD, et al. Among authors: holt jr. Nat Biotechnol. 2017 Mar;35(3):280-284. doi: 10.1038/nbt.3781. Epub 2017 Feb 6. Nat Biotechnol. 2017. PMID: 28165475 Free PMC article.

13

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.

Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS. Pan B, et al. Among authors: holt jr. Nat Biotechnol. 2017 Mar;35(3):264-272. doi: 10.1038/nbt.3801. Epub 2017 Feb 6. Nat Biotechnol. 2017. PMID: 28165476 Free PMC article.

14

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells.

Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E. Koehler KR, et al. Among authors: holt jr. Nat Biotechnol. 2017 Jun;35(6):583-589. doi: 10.1038/nbt.3840. Epub 2017 May 1. Nat Biotechnol. 2017. PMID: 28459451 Free PMC article.

15

Emerging Gene Therapies for Genetic Hearing Loss.

Ahmed H, Shubina-Oleinik O, Holt JR. Ahmed H, et al. Among authors: holt jr. J Assoc Res Otolaryngol. 2017 Oct;18(5):649-670. doi: 10.1007/s10162-017-0634-8. Epub 2017 Aug 16. J Assoc Res Otolaryngol. 2017. PMID: 28815315 Free PMC article. Review.

16

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.

Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR. Gao X, et al. Among authors: holt jr. Nature. 2018 Jan 11;553(7687):217-221. doi: 10.1038/nature25164. Epub 2017 Dec 20. Nature. 2018. PMID: 29258297 Free PMC article.

17

Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.

Nakanishi H, Kurima K, Pan B, Wangemann P, Fitzgerald TS, Géléoc GS, Holt JR, Griffith AJ. Nakanishi H, et al. Among authors: holt jr. Sci Rep. 2018 Aug 14;8(1):12125. doi: 10.1038/s41598-018-29709-8. Sci Rep. 2018. PMID: 30108230 Free PMC article.

18

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1.

Asai Y, Pan B, Nist-Lund C, Galvin A, Lukashkin AN, Lukashkina VA, Chen T, Zhou W, Zhu H, Russell IJ, Holt JR, Géléoc GSG. Asai Y, et al. Among authors: holt jr. Sci Rep. 2018 Aug 14;8(1):12124. doi: 10.1038/s41598-018-28958-x. Sci Rep. 2018. PMID: 30108254 Free PMC article.

19

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.

Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. Pan B, et al. Among authors: holt jr. Neuron. 2018 Aug 22;99(4):736-753.e6. doi: 10.1016/j.neuron.2018.07.033. Neuron. 2018. PMID: 30138589 Free PMC article.

20

Function and Dysfunction of TMC Channels in Inner Ear Hair Cells.

Corey DP, Akyuz N, Holt JR. Corey DP, et al. Among authors: holt jr. Cold Spring Harb Perspect Med. 2019 Oct 1;9(10):a033506. doi: 10.1101/cshperspect.a033506. Cold Spring Harb Perspect Med. 2019. PMID: 30291150 Free PMC article. Review.

21

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Nist-Lund CA, et al. Among authors: holt jr. Nat Commun. 2019 Jan 22;10(1):236. doi: 10.1038/s41467-018-08264-w. Nat Commun. 2019. PMID: 30670701 Free PMC article.

22

Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Nist-Lund CA, et al. Among authors: holt jr. Nat Commun. 2019 Feb 8;10(1):734. doi: 10.1038/s41467-019-08716-x. Nat Commun. 2019. PMID: 30737404 Free PMC article.

23

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.

György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP. György B, et al. Among authors: holt jr. Nat Med. 2019 Jul;25(7):1123-1130. doi: 10.1038/s41591-019-0500-9. Epub 2019 Jul 3. Nat Med. 2019. PMID: 31270503 Free PMC article.

24

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness.

Yeh WH, Shubina-Oleinik O, Levy JM, Pan B, Newby GA, Wornow M, Burt R, Chen JC, Holt JR, Liu DR. Yeh WH, et al. Among authors: holt jr. Sci Transl Med. 2020 Jun 3;12(546):eaay9101. doi: 10.1126/scitranslmed.aay9101. Sci Transl Med. 2020. PMID: 32493795 Free PMC article.

25

Introduction to the Hearing Research special issue on inner ear gene therapy.

Holt JR, Raphael Y. Holt JR, et al. Hear Res. 2020 Sep 1;394:108010. doi: 10.1016/j.heares.2020.108010. Epub 2020 Jun 18. Hear Res. 2020. PMID: 32624335 No abstract available.

26

Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice.

Wu J, Solanes P, Nist-Lund C, Spataro S, Shubina-Oleinik O, Marcovich I, Goldberg H, Schneider BL, Holt JR. Wu J, et al. Among authors: holt jr. Mol Ther. 2021 Mar 3;29(3):973-988. doi: 10.1016/j.ymthe.2020.11.016. Epub 2020 Nov 17. Mol Ther. 2021. PMID: 33212302 Free PMC article.

27

The Mechanosensory Transduction Machinery in Inner Ear Hair Cells.

Zheng W, Holt JR. Zheng W, et al. Among authors: holt jr. Annu Rev Biophys. 2021 May 6;50:31-51. doi: 10.1146/annurev-biophys-062420-081842. Epub 2020 Dec 7. Annu Rev Biophys. 2021. PMID: 33285080 Free PMC article. Review.

28

Putting the Pieces Together: the Hair Cell Transduction Complex.

Holt JR, Tobin M, Elferich J, Gouaux E, Ballesteros A, Yan Z, Ahmed ZM, Nicolson T. Holt JR, et al. J Assoc Res Otolaryngol. 2021 Dec;22(6):601-608. doi: 10.1007/s10162-021-00808-0. Epub 2021 Oct 6. J Assoc Res Otolaryngol. 2021. PMID: 34617206 Free PMC article. Review.

29

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses.

Lee J, Kawai K, Holt JR, Géléoc GS. Lee J, et al. Among authors: holt jr. Elife. 2021 Nov 4;10:e69433. doi: 10.7554/eLife.69433. Elife. 2021. PMID: 34734805 Free PMC article.

30

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

Shubina-Oleinik O, Nist-Lund C, French C, Rockowitz S, Shearer AE, Holt JR. Shubina-Oleinik O, et al. Among authors: holt jr. Sci Adv. 2021 Dec 17;7(51):eabi7629. doi: 10.1126/sciadv.abi7629. Epub 2021 Dec 15. Sci Adv. 2021. PMID: 34910522 Free PMC article.

31

pH regulates potassium conductance and drives a constitutive proton current in human TMEM175.

Zheng W, Shen C, Wang L, Rawson S, Xie WJ, Nist-Lund C, Wu J, Shen Z, Xia S, Holt JR, Wu H, Fu TM. Zheng W, et al. Among authors: holt jr. Sci Adv. 2022 Mar 25;8(12):eabm1568. doi: 10.1126/sciadv.abm1568. Epub 2022 Mar 25. Sci Adv. 2022. PMID: 35333573 Free PMC article.

32

Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors.

van Beelen ESA, van der Valk WH, Verhagen TO, de Groot JCMJ, Madison MA, Shadmanfar W, Hensen EF, Jansen JC, van Benthem PPG, Holt JR, Locher H. van Beelen ESA, et al. Among authors: holt jr. Biomolecules. 2022 Jun 10;12(6):816. doi: 10.3390/biom12060816. Biomolecules. 2022. PMID: 35740941 Free PMC article.

33

A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG. Holt JR, et al. Cell. 2002 Feb 8;108(3):371-81. doi: 10.1016/s0092-8674(02)00629-3. Cell. 2002. PMID: 11853671 Free article.

34

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.

Corey DP, García-Añoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Géléoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DS. Corey DP, et al. Among authors: holt jr. Nature. 2004 Dec 9;432(7018):723-30. doi: 10.1038/nature03066. Epub 2004 Oct 13. Nature. 2004. PMID: 15483558

35

Differential distribution of stem cells in the auditory and vestibular organs of the inner ear.

Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Géléoc GS, Edge A, Holt JR, Heller S. Oshima K, et al. Among authors: holt jr. J Assoc Res Otolaryngol. 2007 Mar;8(1):18-31. doi: 10.1007/s10162-006-0058-3. Epub 2006 Dec 14. J Assoc Res Otolaryngol. 2007. PMID: 17171473 Free PMC article.

36

An in vitro model system to study gene therapy in the human inner ear.

Kesser BW, Hashisaki GT, Fletcher K, Eppard H, Holt JR. Kesser BW, et al. Among authors: holt jr. Gene Ther. 2007 Aug;14(15):1121-31. doi: 10.1038/sj.gt.3302980. Epub 2007 Jun 14. Gene Ther. 2007. PMID: 17568767 Free PMC article.

37

Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear.

Holt JR, Stauffer EA, Abraham D, Géléoc GS. Holt JR, et al. J Neurosci. 2007 Aug 15;27(33):8940-51. doi: 10.1523/JNEUROSCI.2085-07.2007. J Neurosci. 2007. PMID: 17699675 Free PMC article.

38

Gene transfer in human vestibular epithelia and the prospects for inner ear gene therapy.

Kesser BW, Hashisaki GT, Holt JR. Kesser BW, et al. Among authors: holt jr. Laryngoscope. 2008 May;118(5):821-31. doi: 10.1097/MLG.0b013e318164d0aa. Laryngoscope. 2008. PMID: 18300702 Free PMC article.

39

HCN channels expressed in the inner ear are necessary for normal balance function.

Horwitz GC, Risner-Janiczek JR, Jones SM, Holt JR. Horwitz GC, et al. Among authors: holt jr. J Neurosci. 2011 Nov 16;31(46):16814-25. doi: 10.1523/JNEUROSCI.3064-11.2011. J Neurosci. 2011. PMID: 22090507 Free PMC article.

40

Gene therapy for deaf mice goes viral.

Holt JR, Vandenberghe LH. Holt JR, et al. Mol Ther. 2012 Oct;20(10):1836-7. doi: 10.1038/mt.2012.196. Mol Ther. 2012. PMID: 23023054 Free PMC article. No abstract available.

41

Sound strategies for hearing restoration.

Géléoc GS, Holt JR. Géléoc GS, et al. Among authors: holt jr. Science. 2014 May 9;344(6184):1241062. doi: 10.1126/science.1241062. Science. 2014. PMID: 24812404 Free PMC article. Review.

42

Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?

Corey DP, Holt JR. Corey DP, et al. Among authors: holt jr. J Neurosci. 2016 Oct 26;36(43):10921-10926. doi: 10.1523/JNEUROSCI.1148-16.2016. J Neurosci. 2016. PMID: 27798174 Free PMC article.

43

Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness.

Taiber S, Cohen R, Yizhar-Barnea O, Sprinzak D, Holt JR, Avraham KB. Taiber S, et al. Among authors: holt jr. EMBO Mol Med. 2021 Feb 5;13(2):e13259. doi: 10.15252/emmm.202013259. Epub 2020 Dec 22. EMBO Mol Med. 2021. PMID: 33350593 Free PMC article.

44

Sensory transduction in auditory hair cells-PIEZOs can't touch this.

Holt JR, Fettiplace R, Müller U. Holt JR, et al. J Gen Physiol. 2024 Jun 3;156(6):e202413585. doi: 10.1085/jgp.202413585. Epub 2024 May 10. J Gen Physiol. 2024. PMID: 38727631 Free PMC article.

45

Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors.

Holt JR, Johns DC, Wang S, Chen ZY, Dunn RJ, Marban E, Corey DP. Holt JR, et al. J Neurophysiol. 1999 Apr;81(4):1881-8. doi: 10.1152/jn.1999.81.4.1881. J Neurophysiol. 1999. PMID: 10200223 Free article.

46

Two mechanisms for transducer adaptation in vertebrate hair cells.

Holt JR, Corey DP. Holt JR, et al. Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11730-5. doi: 10.1073/pnas.97.22.11730. Proc Natl Acad Sci U S A. 2000. PMID: 11050202 Free PMC article.

47

Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear.

Holt JR. Holt JR. Audiol Neurootol. 2002 May-Jun;7(3):157-60. doi: 10.1159/000058302. Audiol Neurootol. 2002. PMID: 12053137

48

Developmental acquisition of sensory transduction in hair cells of the mouse inner ear.

Géléoc GS, Holt JR. Géléoc GS, et al. Among authors: holt jr. Nat Neurosci. 2003 Oct;6(10):1019-20. doi: 10.1038/nn1120. Epub 2003 Sep 14. Nat Neurosci. 2003. PMID: 12973354 Free PMC article.

49

HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear.

Horwitz GC, Lelli A, Géléoc GS, Holt JR. Horwitz GC, et al. Among authors: holt jr. PLoS One. 2010 Jan 7;5(1):e8627. doi: 10.1371/journal.pone.0008627. PLoS One. 2010. PMID: 20062532 Free PMC article.

50

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.

Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Géléoc GS, Holt JR, Zuo J. Steigelman KA, et al. Among authors: holt jr. J Neurosci. 2011 Aug 24;31(34):12241-50. doi: 10.1523/JNEUROSCI.6531-10.2011. J Neurosci. 2011. PMID: 21865467 Free PMC article.

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