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Page 1
Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators.
Brindani N, Gianotti A, Giovani S, Giacomina F, Di Fruscia P, Sorana F, Bertozzi SM, Ottonello G, Goldoni L, Penna I, Russo D, Summa M, Bertorelli R, Ferrera L, Pesce E, Sondo E, Galietta LJV, Bandiera T, Pedemonte N, Bertozzi F. Brindani N, et al. Among authors: pedemonte n. J Med Chem. 2020 Oct 8;63(19):11169-11194. doi: 10.1021/acs.jmedchem.0c01050. Epub 2020 Sep 18. J Med Chem. 2020. PMID: 32946228 Free PMC article.
Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways.
Candiano G, Bruschi M, Pedemonte N, Caci E, Liberatori S, Bini L, Pellegrini C, Viganò M, O'Connor BJ, Lee TH, Galietta LJ, Zegarra-Moran O. Candiano G, et al. Among authors: pedemonte n. Am J Respir Crit Care Med. 2005 Nov 1;172(9):1090-6. doi: 10.1164/rccm.200409-1185OC. Epub 2005 Aug 11. Am J Respir Crit Care Med. 2005. PMID: 16100010
Effect of inflammatory stimuli on airway ion transport.
Galietta LJ, Folli C, Caci E, Pedemonte N, Taddei A, Ravazzolo R, Zegarra-Moran O. Galietta LJ, et al. Among authors: pedemonte n. Proc Am Thorac Soc. 2004;1(1):62-5. doi: 10.1513/pats.2306017. Proc Am Thorac Soc. 2004. PMID: 16113414 Review.
Proteomic analysis of the airway surface liquid: modulation by proinflammatory cytokines.
Candiano G, Bruschi M, Pedemonte N, Musante L, Ravazzolo R, Liberatori S, Bini L, Galietta LJ, Zegarra-Moran O. Candiano G, et al. Among authors: pedemonte n. Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L185-98. doi: 10.1152/ajplung.00085.2006. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 17215433 Free article.
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia.
Scudieri P, Caci E, Bruno S, Ferrera L, Schiavon M, Sondo E, Tomati V, Gianotti A, Zegarra-Moran O, Pedemonte N, Rea F, Ravazzolo R, Galietta LJ. Scudieri P, et al. Among authors: pedemonte n. J Physiol. 2012 Dec 1;590(23):6141-55. doi: 10.1113/jphysiol.2012.240838. Epub 2012 Sep 17. J Physiol. 2012. PMID: 22988141 Free PMC article.
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis.
Pesce E, Bellotti M, Liessi N, Guariento S, Damonte G, Cichero E, Galatini A, Salis A, Gianotti A, Pedemonte N, Zegarra-Moran O, Fossa P, Galietta LJ, Millo E. Pesce E, et al. Among authors: pedemonte n. Eur J Med Chem. 2015 Jun 24;99:14-35. doi: 10.1016/j.ejmech.2015.05.030. Epub 2015 May 28. Eur J Med Chem. 2015. PMID: 26041577
Novel Hits in the Correction of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis.
Pesci E, Bettinetti L, Fanti P, Galietta LJ, La Rosa S, Magnoni L, Pedemonte N, Sardone GL, Maccari L. Pesci E, et al. Among authors: pedemonte n. J Med Chem. 2015 Dec 24;58(24):9697-711. doi: 10.1021/acs.jmedchem.5b00771. Epub 2015 Dec 7. J Med Chem. 2015. PMID: 26561003
Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.
Tomati V, Caci E, Ferrera L, Pesce E, Sondo E, Cholon DM, Quinney NL, Boyles SE, Armirotti A, Ravazzolo R, Galietta LJ, Gentzsch M, Pedemonte N. Tomati V, et al. Among authors: pedemonte n. JCI Insight. 2018 Feb 8;3(3):e98699. doi: 10.1172/jci.insight.98699. eCollection 2018 Feb 8. JCI Insight. 2018. PMID: 29415893 Free PMC article.
Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia.
Sondo E, Falchi F, Caci E, Ferrera L, Giacomini E, Pesce E, Tomati V, Mandrup Bertozzi S, Goldoni L, Armirotti A, Ravazzolo R, Cavalli A, Pedemonte N. Sondo E, et al. Among authors: pedemonte n. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8. doi: 10.1016/j.chembiol.2018.04.010. Epub 2018 May 10. Cell Chem Biol. 2018. PMID: 29754957 Free article.
Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis.
Haque AKMA, Dewerth A, Antony JS, Riethmüller J, Schweizer GR, Weinmann P, Latifi N, Yasar H, Pedemonte N, Sondo E, Weidensee B, Ralhan A, Laval J, Schlegel P, Seitz C, Loretz B, Lehr CM, Handgretinger R, Kormann MSD. Haque AKMA, et al. Among authors: pedemonte n. Sci Rep. 2018 Nov 13;8(1):16776. doi: 10.1038/s41598-018-34960-0. Sci Rep. 2018. PMID: 30425265 Free PMC article.
The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism.
Pesce E, Sondo E, Ferrera L, Tomati V, Caci E, Scudieri P, Musante I, Renda M, Baatallah N, Servel N, Hinzpeter A, di Bernardo D, Pedemonte N, Galietta LJV. Pesce E, et al. Among authors: pedemonte n. Front Pharmacol. 2018 Dec 13;9:1464. doi: 10.3389/fphar.2018.01464. eCollection 2018. Front Pharmacol. 2018. PMID: 30618756 Free PMC article.
Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.
Tomati V, Caci E, Ferrera L, Pesce E, Sondo E, Cholon DM, Quinney NL, Boyles SE, Armirotti A, Ravazzolo R, Galietta LJ, Gentzsch M, Pedemonte N. Tomati V, et al. Among authors: pedemonte n. JCI Insight. 2019 Apr 4;4(7):e128935. doi: 10.1172/jci.insight.128935. eCollection 2019 Apr 4. JCI Insight. 2019. PMID: 30944255 Free PMC article. No abstract available.
High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs.
Merkert S, Schubert M, Olmer R, Engels L, Radetzki S, Veltman M, Scholte BJ, Zöllner J, Pedemonte N, Galietta LJV, von Kries JP, Martin U. Merkert S, et al. Among authors: pedemonte n. Stem Cell Reports. 2019 Jun 11;12(6):1389-1403. doi: 10.1016/j.stemcr.2019.04.014. Epub 2019 May 9. Stem Cell Reports. 2019. PMID: 31080112 Free PMC article.
Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.
Armirotti A, Tomati V, Matthes E, Veit G, Cholon DM, Phuan PW, Braccia C, Guidone D, Gentzsch M, Lukacs GL, Verkman AS, Galietta LJV, Hanrahan JW, Pedemonte N. Armirotti A, et al. Among authors: pedemonte n. Sci Rep. 2019 Jul 16;9(1):10310. doi: 10.1038/s41598-019-46639-1. Sci Rep. 2019. PMID: 31311979 Free PMC article.
Corrigendum: Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium.
Vega G, Guequén A, Johansson MEV, Arike L, Martínez-Abad B, Nyström EEL, Scudieri P, Pedemonte N, Millar-Büchner P, Philp AR, Galietta LJ, Hansson GC, Flores CA. Vega G, et al. Among authors: pedemonte n. Front Physiol. 2019 Aug 27;10:1040. doi: 10.3389/fphys.2019.01040. eCollection 2019. Front Physiol. 2019. PMID: 31501653 Free PMC article.
CFTR processing, trafficking and interactions.
Amaral MD, Hutt DM, Tomati V, Botelho HM, Pedemonte N. Amaral MD, et al. Among authors: pedemonte n. J Cyst Fibros. 2020 Mar;19 Suppl 1:S33-S36. doi: 10.1016/j.jcf.2019.10.017. Epub 2019 Oct 31. J Cyst Fibros. 2020. PMID: 31680043 Free article. Review.
107 results