Schneider BL - Search Results

1

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B.

Lee J, Nist-Lund C, Solanes P, Goldberg H, Wu J, Pan B, Schneider BL, Holt JR. Lee J, et al. Among authors: schneider bl. Hear Res. 2020 Sep 1;394:107882. doi: 10.1016/j.heares.2020.107882. Epub 2020 Jan 13. Hear Res. 2020. PMID: 31980281 Free article.

2

Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6.

Towne C, Schneider BL, Kieran D, Redmond DE Jr, Aebischer P. Towne C, et al. Among authors: schneider bl. Gene Ther. 2010 Jan;17(1):141-6. doi: 10.1038/gt.2009.119. Epub 2009 Sep 3. Gene Ther. 2010. PMID: 19727139

3

Tmc gene therapy restores auditory function in deaf mice.

Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Askew C, et al. Among authors: schneider bl. Sci Transl Med. 2015 Jul 8;7(295):295ra108. doi: 10.1126/scitranslmed.aab1996. Sci Transl Med. 2015. PMID: 26157030 Free PMC article.

4

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.

György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP. György B, et al. Among authors: schneider bl. Nat Med. 2019 Jul;25(7):1123-1130. doi: 10.1038/s41591-019-0500-9. Epub 2019 Jul 3. Nat Med. 2019. PMID: 31270503 Free PMC article.

5

Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice.

Wu J, Solanes P, Nist-Lund C, Spataro S, Shubina-Oleinik O, Marcovich I, Goldberg H, Schneider BL, Holt JR. Wu J, et al. Among authors: schneider bl. Mol Ther. 2021 Mar 3;29(3):973-988. doi: 10.1016/j.ymthe.2020.11.016. Epub 2020 Nov 17. Mol Ther. 2021. PMID: 33212302 Free PMC article.

6

Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy.

Reilly A, Deguise MO, Beauvais A, Yaworski R, Thebault S, Tessier DR, Tabard-Cossa V, Hensel N, Schneider BL, Kothary R. Reilly A, et al. Among authors: schneider bl. Gene Ther. 2022 Sep;29(9):544-554. doi: 10.1038/s41434-022-00338-1. Epub 2022 Apr 25. Gene Ther. 2022. PMID: 35462564

7

Viral vectors, animal models and new therapies for Parkinson's disease.

Schneider B, Zufferey R, Aebischer P. Schneider B, et al. Parkinsonism Relat Disord. 2008;14 Suppl 2:S169-71. doi: 10.1016/j.parkreldis.2008.04.024. Epub 2008 Jun 27. Parkinsonism Relat Disord. 2008. PMID: 18585946 Review.

8

Neuroprotection by gene therapy targeting mutant SOD1 in individual pools of motor neurons does not translate into therapeutic benefit in fALS mice.

Towne C, Setola V, Schneider BL, Aebischer P. Towne C, et al. Among authors: schneider bl. Mol Ther. 2011 Feb;19(2):274-83. doi: 10.1038/mt.2010.260. Epub 2010 Nov 23. Mol Ther. 2011. PMID: 21102563 Free PMC article.

9

Parkinson's disease: gene therapies.

Coune PG, Schneider BL, Aebischer P. Coune PG, et al. Among authors: schneider bl. Cold Spring Harb Perspect Med. 2012 Apr;2(4):a009431. doi: 10.1101/cshperspect.a009431. Cold Spring Harb Perspect Med. 2012. PMID: 22474617 Free PMC article. Review.

10

Intracerebroventricular injection of adeno-associated virus 6 and 9 vectors for cell type-specific transgene expression in the spinal cord.

Dirren E, Towne CL, Setola V, Redmond DE Jr, Schneider BL, Aebischer P. Dirren E, et al. Among authors: schneider bl. Hum Gene Ther. 2014 Feb;25(2):109-20. doi: 10.1089/hum.2013.021. Epub 2014 Jan 15. Hum Gene Ther. 2014. PMID: 24191919

11

Lentiviral Vectors for the Engineering of Implantable Cells Secreting Recombinant Antibodies.

Lathuilière A, Schneider BL. Lathuilière A, et al. Among authors: schneider bl. Methods Mol Biol. 2016;1448:139-55. doi: 10.1007/978-1-4939-3753-0_11. Methods Mol Biol. 2016. PMID: 27317179

12

Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV).

Blessing D, Déglon N, Schneider BL. Blessing D, et al. Among authors: schneider bl. Methods Mol Biol. 2018;1850:259-274. doi: 10.1007/978-1-4939-8730-6_17. Methods Mol Biol. 2018. PMID: 30242692

13

Long term peripheral AAV9-SMN gene therapy promotes survival in a mouse model of spinal muscular atrophy.

Reilly A, Yaworski R, Beauvais A, Schneider BL, Kothary R. Reilly A, et al. Among authors: schneider bl. Hum Mol Genet. 2024 Feb 28;33(6):510-519. doi: 10.1093/hmg/ddad202. Hum Mol Genet. 2024. PMID: 38073249 Free PMC article.

14

Production and Purification of Adeno-Associated Viral Vectors (AAVs) Using Orbitally Shaken HEK293 Cells.

Gaudry JP, Aebi A, Valdés P, Schneider BL. Gaudry JP, et al. Among authors: schneider bl. Methods Mol Biol. 2024;2810:55-74. doi: 10.1007/978-1-0716-3878-1_4. Methods Mol Biol. 2024. PMID: 38926272

15

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

Ciron C, Lengacher S, Dusonchet J, Aebischer P, Schneider BL. Ciron C, et al. Among authors: schneider bl. Hum Mol Genet. 2012 Apr 15;21(8):1861-76. doi: 10.1093/hmg/ddr618. Epub 2012 Jan 12. Hum Mol Genet. 2012. PMID: 22246294 Free PMC article.

16

Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles.

Löw K, Aebischer P, Schneider BL. Löw K, et al. Among authors: schneider bl. Hum Gene Ther. 2013 Jun;24(6):613-29. doi: 10.1089/hum.2012.174. Hum Gene Ther. 2013. PMID: 23600720 Free PMC article.

17

FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.

Pino E, Amamoto R, Zheng L, Cacquevel M, Sarria JC, Knott GW, Schneider BL. Pino E, et al. Among authors: schneider bl. Hum Mol Genet. 2014 Mar 15;23(6):1435-52. doi: 10.1093/hmg/ddt530. Epub 2013 Oct 24. Hum Mol Genet. 2014. PMID: 24158851

18

Blood Flow to the Spleen is Altered in a Mouse Model of Spinal Muscular Atrophy.

Deguise MO, Beauvais A, Schneider BL, Kothary R. Deguise MO, et al. Among authors: schneider bl. J Neuromuscul Dis. 2020;7(3):315-322. doi: 10.3233/JND-200493. J Neuromuscul Dis. 2020. PMID: 32333548 Free article.

19

Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice.

Towne C, Raoul C, Schneider BL, Aebischer P. Towne C, et al. Among authors: schneider bl. Mol Ther. 2008 Jun;16(6):1018-25. doi: 10.1038/mt.2008.73. Epub 2008 Apr 15. Mol Ther. 2008. PMID: 18414477 Free article.

20

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

Dusonchet J, Kochubey O, Stafa K, Young SM Jr, Zufferey R, Moore DJ, Schneider BL, Aebischer P. Dusonchet J, et al. Among authors: schneider bl. J Neurosci. 2011 Jan 19;31(3):907-12. doi: 10.1523/JNEUROSCI.5092-10.2011. J Neurosci. 2011. PMID: 21248115 Free PMC article.

21

Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease.

Coune PG, Bensadoun JC, Aebischer P, Schneider BL. Coune PG, et al. Among authors: schneider bl. J Parkinsons Dis. 2011;1(4):373-87. doi: 10.3233/JPD-2011-11058. J Parkinsons Dis. 2011. PMID: 23939344 Free article.

22

G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain.

Nguyen APT, Daniel G, Valdés P, Islam MS, Schneider BL, Moore DJ. Nguyen APT, et al. Among authors: schneider bl. Hum Mol Genet. 2018 Jan 1;27(1):120-134. doi: 10.1093/hmg/ddx389. Hum Mol Genet. 2018. PMID: 29088368

23

Astrocyte-targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast-fatigable motor units in a mouse model of amyotrophic lateral sclerosis.

Rochat C, Bernard-Marissal N, Källstig E, Pradervand S, Perrin FE, Aebischer P, Raoul C, Schneider BL. Rochat C, et al. Among authors: schneider bl. Glia. 2022 May;70(5):842-857. doi: 10.1002/glia.24140. Epub 2022 Jan 3. Glia. 2022. PMID: 34978340 Free PMC article.

24

AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice.

Brown SJ, Šoltić D, Synowsky SA, Shirran SL, Chilcott E, Shorrock HK, Gillingwater TH, Yáñez-Muñoz RJ, Schneider B, Bowerman M, Fuller HR. Brown SJ, et al. Hum Mol Genet. 2023 Oct 4;32(20):2950-2965. doi: 10.1093/hmg/ddad121. Hum Mol Genet. 2023. PMID: 37498175 Free PMC article.

25

Liver SMN restoration rescues the Smn^2B/- mouse model of spinal muscular atrophy.

Sutton ER, Beauvais A, Yaworski R, De Repentigny Y, Reilly A, Alves de Almeida MM, Deguise MO, Poulin KL, Parks RJ, Schneider BL, Kothary R. Sutton ER, et al. Among authors: schneider bl. EBioMedicine. 2024 Dec;110:105444. doi: 10.1016/j.ebiom.2024.105444. Epub 2024 Nov 7. EBioMedicine. 2024. PMID: 39515026 Free PMC article.

26

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker.

Coune PG, Craveiro M, Gaugler MN, Mlynárik V, Schneider BL, Aebischer P, Gruetter R. Coune PG, et al. Among authors: schneider bl. NMR Biomed. 2013 Jan;26(1):43-50. doi: 10.1002/nbm.2817. Epub 2012 Jun 18. NMR Biomed. 2013. PMID: 22711560

27

SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice.

Dirren E, Aebischer J, Rochat C, Towne C, Schneider BL, Aebischer P. Dirren E, et al. Among authors: schneider bl. Ann Clin Transl Neurol. 2015 Feb;2(2):167-84. doi: 10.1002/acn3.162. Epub 2015 Jan 15. Ann Clin Transl Neurol. 2015. PMID: 25750921 Free PMC article.

28

Overview of mouse models of Parkinson's disease.

Bobela W, Zheng L, Schneider BL. Bobela W, et al. Among authors: schneider bl. Curr Protoc Mouse Biol. 2014 Sep 3;4(3):121-39. doi: 10.1002/9780470942390.mo140092. Curr Protoc Mouse Biol. 2014. PMID: 25723963

29

Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease?

Valdés P, Schneider BL. Valdés P, et al. Among authors: schneider bl. Front Neuroanat. 2016 Dec 20;10:123. doi: 10.3389/fnana.2016.00123. eCollection 2016. Front Neuroanat. 2016. PMID: 28066194 Free PMC article. Review.

30

An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator.

Bethge P, Carta S, Lorenzo DA, Egolf L, Goniotaki D, Madisen L, Voigt FF, Chen JL, Schneider B, Ohkura M, Nakai J, Zeng H, Aguzzi A, Helmchen F. Bethge P, et al. PLoS One. 2017 Jun 22;12(6):e0179460. doi: 10.1371/journal.pone.0179460. eCollection 2017. PLoS One. 2017. PMID: 28640817 Free PMC article.

31

Glutaredoxin1 Diminishes Amyloid Beta-Mediated Oxidation of F-Actin and Reverses Cognitive Deficits in an Alzheimer's Disease Mouse Model.

Kommaddi RP, Tomar DS, Karunakaran S, Bapat D, Nanguneri S, Ray A, Schneider BL, Nair D, Ravindranath V. Kommaddi RP, et al. Among authors: schneider bl. Antioxid Redox Signal. 2019 Dec 20;31(18):1321-1338. doi: 10.1089/ars.2019.7754. Antioxid Redox Signal. 2019. PMID: 31617375

32

Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity.

Reimann RR, Puzio M, Rosati A, Emmenegger M, Schneider BL, Valdés P, Huang D, Caflisch A, Aguzzi A. Reimann RR, et al. Among authors: schneider bl. Brain Pathol. 2023 Mar;33(2):e13130. doi: 10.1111/bpa.13130. Epub 2022 Nov 3. Brain Pathol. 2023. PMID: 36329611 Free PMC article.

33

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells.

Blessing D, Vachey G, Pythoud C, Rey M, Padrun V, Wurm FM, Schneider BL, Déglon N. Blessing D, et al. Among authors: schneider bl. Mol Ther Methods Clin Dev. 2018 Nov 22;13:14-26. doi: 10.1016/j.omtm.2018.11.004. eCollection 2019 Jun 14. Mol Ther Methods Clin Dev. 2018. PMID: 30591923 Free PMC article.

34

Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts.

Sommer B, Rinsch C, Payen E, Dalle B, Schneider B, Déglon N, Henri A, Beuzard Y, Aebischer P. Sommer B, et al. Mol Ther. 2002 Aug;6(2):155-61. doi: 10.1006/mthe.2002.0646. Mol Ther. 2002. PMID: 12161181 Free article.

35

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.

Tsika E, Nguyen AP, Dusonchet J, Colin P, Schneider BL, Moore DJ. Tsika E, et al. Among authors: schneider bl. Neurobiol Dis. 2015 May;77:49-61. doi: 10.1016/j.nbd.2015.02.019. Epub 2015 Feb 28. Neurobiol Dis. 2015. PMID: 25731749

36

Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology.

Laversenne V, Nazeeruddin S, Källstig EC, Colin P, Voize C, Schneider BL. Laversenne V, et al. Among authors: schneider bl. Acta Neuropathol Commun. 2020 Nov 23;8(1):198. doi: 10.1186/s40478-020-01069-3. Acta Neuropathol Commun. 2020. PMID: 33225991 Free PMC article.

37

IL10- and IL35-Secreting MutuDC Lines Act in Cooperation to Inhibit Memory T Cell Activation Through LAG-3 Expression.

Koga MM, Engel A, Pigni M, Lavanchy C, Stevanin M, Laversenne V, Schneider BL, Acha-Orbea H. Koga MM, et al. Among authors: schneider bl. Front Immunol. 2021 Feb 17;12:607315. doi: 10.3389/fimmu.2021.607315. eCollection 2021. Front Immunol. 2021. PMID: 33679743 Free PMC article.

38

CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice.

Caló L, Hidari E, Wegrzynowicz M, Dalley JW, Schneider BL, Podgajna M, Anichtchik O, Carlson E, Klenerman D, Spillantini MG. Caló L, et al. Among authors: schneider bl. Brain. 2021 Jul 28;144(6):1661-1669. doi: 10.1093/brain/awab076. Brain. 2021. PMID: 33760024 Free PMC article.

39

Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.

Oueslati A, Paleologou KE, Schneider BL, Aebischer P, Lashuel HA. Oueslati A, et al. Among authors: schneider bl. J Neurosci. 2012 Feb 1;32(5):1536-44. doi: 10.1523/JNEUROSCI.3784-11.2012. J Neurosci. 2012. PMID: 22302797 Free PMC article.

40

Mitofusin-2 in the Nucleus Accumbens Regulates Anxiety and Depression-like Behaviors Through Mitochondrial and Neuronal Actions.

Gebara E, Zanoletti O, Ghosal S, Grosse J, Schneider BL, Knott G, Astori S, Sandi C. Gebara E, et al. Among authors: schneider bl. Biol Psychiatry. 2021 Jun 1;89(11):1033-1044. doi: 10.1016/j.biopsych.2020.12.003. Epub 2020 Dec 8. Biol Psychiatry. 2021. PMID: 33583561 Free article.

41

Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease.

Dusonchet J, Bensadoun JC, Schneider BL, Aebischer P. Dusonchet J, et al. Among authors: schneider bl. Neurobiol Dis. 2009 Jul;35(1):32-41. doi: 10.1016/j.nbd.2009.03.013. Epub 2009 Apr 5. Neurobiol Dis. 2009. PMID: 19348945

42

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.

Bobela W, Nazeeruddin S, Knott G, Aebischer P, Schneider BL. Bobela W, et al. Among authors: schneider bl. Mol Neurodegener. 2017 Nov 3;12(1):80. doi: 10.1186/s13024-017-0220-x. Mol Neurodegener. 2017. PMID: 29100525 Free PMC article.

43

Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?

Bernard-Marissal N, Chrast R, Schneider BL. Bernard-Marissal N, et al. Among authors: schneider bl. Cell Death Dis. 2018 Feb 28;9(3):333. doi: 10.1038/s41419-017-0125-1. Cell Death Dis. 2018. PMID: 29491369 Free PMC article. Review.

44

SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease.

Deguise MO, Pileggi C, De Repentigny Y, Beauvais A, Tierney A, Chehade L, Michaud J, Llavero-Hurtado M, Lamont D, Atrih A, Wishart TM, Gillingwater TH, Schneider BL, Harper ME, Parson SH, Kothary R. Deguise MO, et al. Among authors: schneider bl. Cell Mol Gastroenterol Hepatol. 2021;12(1):354-377.e3. doi: 10.1016/j.jcmgh.2021.01.019. Epub 2021 Feb 2. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33545428 Free PMC article.

45

The Links between ALS and NF-κB.

Källstig E, McCabe BD, Schneider BL. Källstig E, et al. Among authors: schneider bl. Int J Mol Sci. 2021 Apr 8;22(8):3875. doi: 10.3390/ijms22083875. Int J Mol Sci. 2021. PMID: 33918092 Free PMC article. Review.

46

The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging.

Wohlwend M, Laurila PP, Williams K, Romani M, Lima T, Pattawaran P, Benegiamo G, Salonen M, Schneider BL, Lahti J, Eriksson JG, Barrès R, Wisløff U, Moreira JBN, Auwerx J. Wohlwend M, et al. Among authors: schneider bl. Sci Transl Med. 2021 Dec 8;13(623):eabc7367. doi: 10.1126/scitranslmed.abc7367. Epub 2021 Dec 8. Sci Transl Med. 2021. PMID: 34878822

47

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

Gaugler MN, Genc O, Bobela W, Mohanna S, Ardah MT, El-Agnaf OM, Cantoni M, Bensadoun JC, Schneggenburger R, Knott GW, Aebischer P, Schneider BL. Gaugler MN, et al. Among authors: schneider bl. Acta Neuropathol. 2012 May;123(5):653-69. doi: 10.1007/s00401-012-0963-y. Epub 2012 Feb 24. Acta Neuropathol. 2012. PMID: 22361813

48

A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells.

Lathuilière A, Cosson S, Lutolf MP, Schneider BL, Aebischer P. Lathuilière A, et al. Among authors: schneider bl. Biomaterials. 2014 Jan;35(2):779-91. doi: 10.1016/j.biomaterials.2013.09.071. Epub 2013 Oct 5. Biomaterials. 2014. PMID: 24103654

49

Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice.

Verma A, Ray A, Bapat D, Diwakar L, Kommaddi RP, Schneider BL, Hirsch EC, Ravindranath V. Verma A, et al. Among authors: schneider bl. Mov Disord. 2020 Oct;35(10):1843-1853. doi: 10.1002/mds.28190. Epub 2020 Jul 3. Mov Disord. 2020. PMID: 32618039 Free article.

50

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease.

Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T, Aebischer P. Lo Bianco C, et al. Among authors: schneider bl. Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17510-5. doi: 10.1073/pnas.0405313101. Epub 2004 Dec 2. Proc Natl Acad Sci U S A. 2004. PMID: 15576511 Free PMC article.

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