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Page 1
A small-molecule antivirulence agent for treating Clostridium difficile infection.
Bender KO, Garland M, Ferreyra JA, Hryckowian AJ, Child MA, Puri AW, Solow-Cordero DE, Higginbottom SK, Segal E, Banaei N, Shen A, Sonnenburg JL, Bogyo M. Bender KO, et al. Among authors: sonnenburg jl. Sci Transl Med. 2015 Sep 23;7(306):306ra148. doi: 10.1126/scitranslmed.aac9103. Epub 2015 Sep 23. Sci Transl Med. 2015. PMID: 26400909 Free PMC article.
The emerging metabolic view of Clostridium difficile pathogenesis.
Hryckowian AJ, Pruss KM, Sonnenburg JL. Hryckowian AJ, et al. Among authors: sonnenburg jl. Curr Opin Microbiol. 2017 Feb;35:42-47. doi: 10.1016/j.mib.2016.11.006. Epub 2016 Dec 19. Curr Opin Microbiol. 2017. PMID: 27997854 Free PMC article. Review.
Links between environment, diet, and the hunter-gatherer microbiome.
Fragiadakis GK, Smits SA, Sonnenburg ED, Van Treuren W, Reid G, Knight R, Manjurano A, Changalucha J, Dominguez-Bello MG, Leach J, Sonnenburg JL. Fragiadakis GK, et al. Among authors: sonnenburg jl, sonnenburg ed. Gut Microbes. 2019;10(2):216-227. doi: 10.1080/19490976.2018.1494103. Epub 2018 Aug 17. Gut Microbes. 2019. PMID: 30118385 Free PMC article.
Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea.
Battaglioli EJ, Hale VL, Chen J, Jeraldo P, Ruiz-Mojica C, Schmidt BA, Rekdal VM, Till LM, Huq L, Smits SA, Moor WJ, Jones-Hall Y, Smyrk T, Khanna S, Pardi DS, Grover M, Patel R, Chia N, Nelson H, Sonnenburg JL, Farrugia G, Kashyap PC. Battaglioli EJ, et al. Among authors: sonnenburg jl. Sci Transl Med. 2018 Oct 24;10(464):eaam7019. doi: 10.1126/scitranslmed.aam7019. Sci Transl Med. 2018. PMID: 30355801 Free PMC article.
Western diet regulates immune status and the response to LPS-driven sepsis independent of diet-associated microbiome.
Napier BA, Andres-Terre M, Massis LM, Hryckowian AJ, Higginbottom SK, Cumnock K, Casey KM, Haileselassie B, Lugo KA, Schneider DS, Sonnenburg JL, Monack DM. Napier BA, et al. Among authors: sonnenburg jl. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3688-3694. doi: 10.1073/pnas.1814273116. Epub 2019 Feb 11. Proc Natl Acad Sci U S A. 2019. PMID: 30808756 Free PMC article.
Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs.
Ng KM, Aranda-Díaz A, Tropini C, Frankel MR, Van Treuren W, O'Loughlin CT, Merrill BD, Yu FB, Pruss KM, Oliveira RA, Higginbottom SK, Neff NF, Fischbach MA, Xavier KB, Sonnenburg JL, Huang KC. Ng KM, et al. Among authors: sonnenburg jl. Cell Host Microbe. 2019 Nov 13;26(5):650-665.e4. doi: 10.1016/j.chom.2019.10.011. Cell Host Microbe. 2019. PMID: 31726029 Free PMC article.
Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.
Sinha SR, Haileselassie Y, Nguyen LP, Tropini C, Wang M, Becker LS, Sim D, Jarr K, Spear ET, Singh G, Namkoong H, Bittinger K, Fischbach MA, Sonnenburg JL, Habtezion A. Sinha SR, et al. Among authors: sonnenburg jl. Cell Host Microbe. 2020 Apr 8;27(4):659-670.e5. doi: 10.1016/j.chom.2020.01.021. Epub 2020 Feb 25. Cell Host Microbe. 2020. PMID: 32101703 Free PMC article.
Gut-microbiota-targeted diets modulate human immune status.
Wastyk HC, Fragiadakis GK, Perelman D, Dahan D, Merrill BD, Yu FB, Topf M, Gonzalez CG, Van Treuren W, Han S, Robinson JL, Elias JE, Sonnenburg ED, Gardner CD, Sonnenburg JL. Wastyk HC, et al. Among authors: sonnenburg jl, sonnenburg ed. Cell. 2021 Aug 5;184(16):4137-4153.e14. doi: 10.1016/j.cell.2021.06.019. Epub 2021 Jul 12. Cell. 2021. PMID: 34256014 Free PMC article. Clinical Trial.
Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization.
Pruss KM, Enam F, Battaglioli E, DeFeo M, Diaz OR, Higginbottom SK, Fischer CR, Hryckowian AJ, Van Treuren W, Dodd D, Kashyap P, Sonnenburg JL. Pruss KM, et al. Among authors: sonnenburg jl. Nat Metab. 2022 Jan;4(1):19-28. doi: 10.1038/s42255-021-00506-4. Epub 2022 Jan 6. Nat Metab. 2022. PMID: 34992297 Free PMC article.
Butyrate Differentiates Permissiveness to Clostridioides difficile Infection and Influences Growth of Diverse C. difficile Isolates.
Pensinger DA, Fisher AT, Dobrila HA, Van Treuren W, Gardner JO, Higginbottom SK, Carter MM, Schumann B, Bertozzi CR, Anikst V, Martin C, Robilotti EV, Chow JM, Buck RH, Tompkins LS, Sonnenburg JL, Hryckowian AJ. Pensinger DA, et al. Among authors: sonnenburg jl. Infect Immun. 2023 Feb 16;91(2):e0057022. doi: 10.1128/iai.00570-22. Epub 2023 Jan 24. Infect Immun. 2023. PMID: 36692308 Free PMC article.
Microbiome engineering.
Sonnenburg JL. Sonnenburg JL. Nature. 2015 Feb 26;518(7540):S10. doi: 10.1038/518S10a. Nature. 2015. PMID: 25715274 No abstract available.
Quantitative Imaging of Gut Microbiota Spatial Organization.
Earle KA, Billings G, Sigal M, Lichtman JS, Hansson GC, Elias JE, Amieva MR, Huang KC, Sonnenburg JL. Earle KA, et al. Among authors: sonnenburg jl. Cell Host Microbe. 2015 Oct 14;18(4):478-88. doi: 10.1016/j.chom.2015.09.002. Epub 2015 Oct 1. Cell Host Microbe. 2015. PMID: 26439864 Free PMC article.
The Gut Microbiome: Connecting Spatial Organization to Function.
Tropini C, Earle KA, Huang KC, Sonnenburg JL. Tropini C, et al. Among authors: sonnenburg jl. Cell Host Microbe. 2017 Apr 12;21(4):433-442. doi: 10.1016/j.chom.2017.03.010. Cell Host Microbe. 2017. PMID: 28407481 Free PMC article. Review.
Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania.
Smits SA, Leach J, Sonnenburg ED, Gonzalez CG, Lichtman JS, Reid G, Knight R, Manjurano A, Changalucha J, Elias JE, Dominguez-Bello MG, Sonnenburg JL. Smits SA, et al. Among authors: sonnenburg jl, sonnenburg ed. Science. 2017 Aug 25;357(6353):802-806. doi: 10.1126/science.aan4834. Science. 2017. PMID: 28839072 Free PMC article.
Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota.
Tropini C, Moss EL, Merrill BD, Ng KM, Higginbottom SK, Casavant EP, Gonzalez CG, Fremin B, Bouley DM, Elias JE, Bhatt AS, Huang KC, Sonnenburg JL. Tropini C, et al. Among authors: sonnenburg jl. Cell. 2018 Jun 14;173(7):1742-1754.e17. doi: 10.1016/j.cell.2018.05.008. Cell. 2018. PMID: 29906449 Free PMC article.
A Microbiota Assimilation.
Sonnenburg J, Sonnenburg E. Sonnenburg J, et al. Cell Metab. 2018 Nov 6;28(5):675-677. doi: 10.1016/j.cmet.2018.10.010. Cell Metab. 2018. PMID: 30403987 Free article.
Depletion of microbiome-derived molecules in the host using Clostridium genetics.
Guo CJ, Allen BM, Hiam KJ, Dodd D, Van Treuren W, Higginbottom S, Nagashima K, Fischer CR, Sonnenburg JL, Spitzer MH, Fischbach MA. Guo CJ, et al. Among authors: sonnenburg jl. Science. 2019 Dec 13;366(6471):eaav1282. doi: 10.1126/science.aav1282. Science. 2019. PMID: 31831639 Free PMC article.
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome.
Mars RAT, Yang Y, Ward T, Houtti M, Priya S, Lekatz HR, Tang X, Sun Z, Kalari KR, Korem T, Bhattarai Y, Zheng T, Bar N, Frost G, Johnson AJ, van Treuren W, Han S, Ordog T, Grover M, Sonnenburg J, D'Amato M, Camilleri M, Elinav E, Segal E, Blekhman R, Farrugia G, Swann JR, Knights D, Kashyap PC. Mars RAT, et al. Cell. 2020 Sep 17;182(6):1460-1473.e17. doi: 10.1016/j.cell.2020.08.007. Epub 2020 Sep 10. Cell. 2020. PMID: 32916129 Free PMC article.
Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs.
Ng KM, Aranda-Díaz A, Tropini C, Frankel MR, Van Treuren W, O'Loughlin CT, Merrill BD, Yu FB, Pruss KM, Oliveira RA, Higginbottom SK, Neff NF, Fischbach MA, Xavier KB, Sonnenburg JL, Huang KC. Ng KM, et al. Among authors: sonnenburg jl. Cell Host Microbe. 2020 Oct 7;28(4):628. doi: 10.1016/j.chom.2020.09.001. Cell Host Microbe. 2020. PMID: 33031771 Free article. No abstract available.
Reporting guidelines for human microbiome research: the STORMS checklist.
Mirzayi C, Renson A; Genomic Standards Consortium; Massive Analysis and Quality Control Society; Zohra F, Elsafoury S, Geistlinger L, Kasselman LJ, Eckenrode K, van de Wijgert J, Loughman A, Marques FZ, MacIntyre DA, Arumugam M, Azhar R, Beghini F, Bergstrom K, Bhatt A, Bisanz JE, Braun J, Bravo HC, Buck GA, Bushman F, Casero D, Clarke G, Collado MC, Cotter PD, Cryan JF, Demmer RT, Devkota S, Elinav E, Escobar JS, Fettweis J, Finn RD, Fodor AA, Forslund S, Franke A, Furlanello C, Gilbert J, Grice E, Haibe-Kains B, Handley S, Herd P, Holmes S, Jacobs JP, Karstens L, Knight R, Knights D, Koren O, Kwon DS, Langille M, Lindsay B, McGovern D, McHardy AC, McWeeney S, Mueller NT, Nezi L, Olm M, Palm N, Pasolli E, Raes J, Redinbo MR, Rühlemann M, Balfour Sartor R, Schloss PD, Schriml L, Segal E, Shardell M, Sharpton T, Smirnova E, Sokol H, Sonnenburg JL, Srinivasan S, Thingholm LB, Turnbaugh PJ, Upadhyay V, Walls RL, Wilmes P, Yamada T, Zeller G, Zhang M, Zhao N, Zhao L, Bao W, Culhane A, Devanarayan V, Dopazo J, Fan X, Fischer M, Jones W, Kusko R, Mason CE, Mercer TR, Sansone SA, Scherer A, Shi L, Thakkar S, Tong W, Wolfinger R, Hunter C, Segata N, Huttenhower C, Dowd JB, Jones HE… See abstract for full author list ➔ Mirzayi C, et al. Among authors: sonnenburg jl. Nat Med. 2021 Nov;27(11):1885-1892. doi: 10.1038/s41591-021-01552-x. Epub 2021 Nov 17. Nat Med. 2021. PMID: 34789871 Free PMC article. Review.
Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota.
Aranda-Díaz A, Ng KM, Thomsen T, Real-Ramírez I, Dahan D, Dittmar S, Gonzalez CG, Chavez T, Vasquez KS, Nguyen TH, Yu FB, Higginbottom SK, Neff NF, Elias JE, Sonnenburg JL, Huang KC. Aranda-Díaz A, et al. Among authors: sonnenburg jl. Cell Host Microbe. 2022 Feb 9;30(2):260-272.e5. doi: 10.1016/j.chom.2021.12.008. Epub 2022 Jan 19. Cell Host Microbe. 2022. PMID: 35051349 Free PMC article.
Design, construction, and in vivo augmentation of a complex gut microbiome.
Cheng AG, Ho PY, Aranda-Díaz A, Jain S, Yu FB, Meng X, Wang M, Iakiviak M, Nagashima K, Zhao A, Murugkar P, Patil A, Atabakhsh K, Weakley A, Yan J, Brumbaugh AR, Higginbottom S, Dimas A, Shiver AL, Deutschbauer A, Neff N, Sonnenburg JL, Huang KC, Fischbach MA. Cheng AG, et al. Among authors: sonnenburg jl. Cell. 2022 Sep 15;185(19):3617-3636.e19. doi: 10.1016/j.cell.2022.08.003. Epub 2022 Sep 6. Cell. 2022. PMID: 36070752 Free PMC article.
Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes.
Carter MM, Olm MR, Merrill BD, Dahan D, Tripathi S, Spencer SP, Yu FB, Jain S, Neff N, Jha AR, Sonnenburg ED, Sonnenburg JL. Carter MM, et al. Among authors: sonnenburg jl. Cell. 2023 Jul 6;186(14):3111-3124.e13. doi: 10.1016/j.cell.2023.05.046. Epub 2023 Jun 21. Cell. 2023. PMID: 37348505 Free article.
Randomly barcoded transposon mutant libraries for gut commensals I: Strategies for efficient library construction.
Tripathi S, Voogdt CGP, Bassler SO, Anderson M, Huang PH, Sakenova N, Capraz T, Jain S, Koumoutsi A, Bravo AM, Trotter V, Zimmerman M, Sonnenburg JL, Buie C, Typas A, Deutschbauer AM, Shiver AL, Huang KC. Tripathi S, et al. Among authors: sonnenburg jl. Cell Rep. 2024 Jan 23;43(1):113517. doi: 10.1016/j.celrep.2023.113517. Epub 2023 Dec 23. Cell Rep. 2024. PMID: 38142397 Free article. Review.
Randomly barcoded transposon mutant libraries for gut commensals II: Applying libraries for functional genetics.
Voogdt CGP, Tripathi S, Bassler SO, McKeithen-Mead SA, Guiberson ER, Koumoutsi A, Bravo AM, Buie C, Zimmermann M, Sonnenburg JL, Typas A, Deutschbauer AM, Shiver AL, Huang KC. Voogdt CGP, et al. Among authors: sonnenburg jl. Cell Rep. 2024 Jan 23;43(1):113519. doi: 10.1016/j.celrep.2023.113519. Epub 2023 Dec 23. Cell Rep. 2024. PMID: 38142398 Free article. Review.
Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice.
Kashyap PC, Marcobal A, Ursell LK, Larauche M, Duboc H, Earle KA, Sonnenburg ED, Ferreyra JA, Higginbottom SK, Million M, Tache Y, Pasricha PJ, Knight R, Farrugia G, Sonnenburg JL. Kashyap PC, et al. Among authors: sonnenburg jl, sonnenburg ed. Gastroenterology. 2013 May;144(5):967-77. doi: 10.1053/j.gastro.2013.01.047. Epub 2013 Feb 1. Gastroenterology. 2013. PMID: 23380084 Free PMC article.
Gut microbes take their vitamins.
Sonnenburg ED, Sonnenburg JL. Sonnenburg ED, et al. Among authors: sonnenburg jl. Cell Host Microbe. 2014 Jan 15;15(1):5-6. doi: 10.1016/j.chom.2013.12.011. Cell Host Microbe. 2014. PMID: 24439893 Free PMC article.
Monitoring host responses to the gut microbiota.
Lichtman JS, Sonnenburg JL, Elias JE. Lichtman JS, et al. Among authors: sonnenburg jl. ISME J. 2015 Sep;9(9):1908-15. doi: 10.1038/ismej.2015.93. Epub 2015 Jun 9. ISME J. 2015. PMID: 26057846 Free PMC article. Review.
139 results