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Page 1
Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes.
Esser K, Cheng X, Wettengel JM, Lucifora J, Hansen-Palmus L, Austen K, Roca Suarez AA, Heintz S, Testoni B, Nebioglu F, Pham MT, Yang S, Zernecke A, Wohlleber D, Ringelhan M, Broxtermann M, Hartmann D, Hüser N, Mergner J, Pichlmair A, Thasler WE, Heikenwalder M, Gasteiger G, Blutke A, Walch A, Knolle PA, Bartenschlager R, Protzer U. Esser K, et al. Among authors: wohlleber d. Cell Mol Gastroenterol Hepatol. 2023;16(2):201-221. doi: 10.1016/j.jcmgh.2023.03.011. Epub 2023 Apr 11. Cell Mol Gastroenterol Hepatol. 2023. PMID: 37054914 Free PMC article.
TNF-induced target cell killing by CTL activated through cross-presentation.
Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA. Wohlleber D, et al. Cell Rep. 2012 Sep 27;2(3):478-87. doi: 10.1016/j.celrep.2012.08.001. Epub 2012 Aug 30. Cell Rep. 2012. PMID: 22939982 Free article.
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA. Huang LR, et al. Among authors: wohlleber d. Nat Immunol. 2013 Jun;14(6):574-83. doi: 10.1038/ni.2573. Epub 2013 Apr 14. Nat Immunol. 2013. PMID: 23584070
Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes.
Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M. Wolf MJ, et al. Among authors: wohlleber d. Cancer Cell. 2014 Oct 13;26(4):549-64. doi: 10.1016/j.ccell.2014.09.003. Cancer Cell. 2014. PMID: 25314080 Free article.
T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice.
Dargel C, Bassani-Sternberg M, Hasreiter J, Zani F, Bockmann JH, Thiele F, Bohne F, Wisskirchen K, Wilde S, Sprinzl MF, Schendel DJ, Krackhardt AM, Uckert W, Wohlleber D, Schiemann M, Stemmer K, Heikenwälder M, Busch DH, Richter G, Mann M, Protzer U. Dargel C, et al. Among authors: wohlleber d. Gastroenterology. 2015 Oct;149(4):1042-52. doi: 10.1053/j.gastro.2015.05.055. Epub 2015 Jun 5. Gastroenterology. 2015. PMID: 26052074
Immunological functions of liver sinusoidal endothelial cells.
Knolle PA, Wohlleber D. Knolle PA, et al. Among authors: wohlleber d. Cell Mol Immunol. 2016 May;13(3):347-53. doi: 10.1038/cmi.2016.5. Epub 2016 Apr 4. Cell Mol Immunol. 2016. PMID: 27041636 Free PMC article. Review.
Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver.
Grünwald B, Harant V, Schaten S, Frühschütz M, Spallek R, Höchst B, Stutzer K, Berchtold S, Erkan M, Prokopchuk O, Martignoni M, Esposito I, Heikenwalder M, Gupta A, Siveke J, Saftig P, Knolle P, Wohlleber D, Krüger A. Grünwald B, et al. Among authors: wohlleber d. Gastroenterology. 2016 Nov;151(5):1011-1024.e7. doi: 10.1053/j.gastro.2016.07.043. Epub 2016 Aug 6. Gastroenterology. 2016. PMID: 27506299
Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.
Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M. Yuan D, et al. Among authors: wohlleber d. Cancer Cell. 2017 Jun 12;31(6):771-789.e6. doi: 10.1016/j.ccell.2017.05.006. Cancer Cell. 2017. PMID: 28609656 Free PMC article.
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.
O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M. O'Connor T, et al. Among authors: wohlleber d. Cancer Cell. 2019 Sep 16;36(3):250-267.e9. doi: 10.1016/j.ccell.2019.08.001. Cancer Cell. 2019. PMID: 31526758 Free article.
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. Namineni S, et al. Among authors: wohlleber d. J Hepatol. 2020 May;72(5):960-975. doi: 10.1016/j.jhep.2019.12.019. Epub 2020 Jan 15. J Hepatol. 2020. PMID: 31954207 Free article.
The CGRP receptor component RAMP1 links sensory innervation with YAP activity in the regenerating liver.
Laschinger M, Wang Y, Holzmann G, Wang B, Stöß C, Lu M, Brugger M, Schneider A, Knolle P, Wohlleber D, Schulze S, Steiger K, Tsujikawa K, Altmayr F, Friess H, Hartmann D, Hüser N, Holzmann B. Laschinger M, et al. Among authors: wohlleber d. FASEB J. 2020 Jun;34(6):8125-8138. doi: 10.1096/fj.201903200R. Epub 2020 Apr 23. FASEB J. 2020. PMID: 32329113
Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.
Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Kläger S, Küster B, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perocchi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA, Wohlleber D. Lampl S, et al. Among authors: wohlleber d. J Hepatol. 2020 Dec;73(6):1347-1359. doi: 10.1016/j.jhep.2020.06.026. Epub 2020 Jun 26. J Hepatol. 2020. PMID: 32598967
Gut microbiota promote liver regeneration through hepatic membrane phospholipid biosynthesis.
Yin Y, Sichler A, Ecker J, Laschinger M, Liebisch G, Höring M, Basic M, Bleich A, Zhang XJ, Kübelsbeck L, Plagge J, Scherer E, Wohlleber D, Wang J, Wang Y, Steffani M, Stupakov P, Gärtner Y, Lohöfer F, Mogler C, Friess H, Hartmann D, Holzmann B, Hüser N, Janssen KP. Yin Y, et al. Among authors: wohlleber d. J Hepatol. 2023 Apr;78(4):820-835. doi: 10.1016/j.jhep.2022.12.028. Epub 2023 Jan 18. J Hepatol. 2023. PMID: 36681162
Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells.
Winkler F, Hipp AV, Ramirez C, Martin B, Villa M, Neuwirt E, Gorka O, Aerssens J, Johansson SE, Rana N, Llewellyn-Lacey S, Price DA, Panning M, Groß O, Pearce EL, Hermann CM, Schumann K, Hannibal L, Neumann-Haefelin C, Boettler T, Knolle P, Hofmann M, Wohlleber D, Thimme R, Bengsch B. Winkler F, et al. Among authors: wohlleber d. Gut. 2023 Oct;72(10):1971-1984. doi: 10.1136/gutjnl-2022-328734. Epub 2023 Aug 4. Gut. 2023. PMID: 37541771 Free PMC article.
IAP antagonization promotes inflammatory destruction of vascular endothelium.
Witt A, Seeger JM, Coutelle O, Zigrino P, Broxtermann P, Andree M, Brinkmann K, Jüngst C, Schauss AC, Schüll S, Wohlleber D, Knolle PA, Krönke M, Mauch C, Kashkar H. Witt A, et al. Among authors: wohlleber d. EMBO Rep. 2015 Jun;16(6):719-27. doi: 10.15252/embr.201439616. Epub 2015 Mar 30. EMBO Rep. 2015. PMID: 25825408 Free PMC article.
Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.
Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W. Welz M, et al. Among authors: wohlleber d. Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x. Nat Commun. 2018. PMID: 30442932 Free PMC article.
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.
Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hoesslin M, Cullen JG, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R, Youngblood B, Zehn D. Alfei F, et al. Among authors: wohlleber d. Nature. 2019 Jul;571(7764):265-269. doi: 10.1038/s41586-019-1326-9. Epub 2019 Jun 17. Nature. 2019. PMID: 31207605
NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.
Laudenbach BT, Krey K, Emslander Q, Andersen LL, Reim A, Scaturro P, Mundigl S, Dächert C, Manske K, Moser M, Ludwig J, Wohlleber D, Kröger A, Binder M, Pichlmair A. Laudenbach BT, et al. Among authors: wohlleber d. Nat Commun. 2021 Nov 25;12(1):6918. doi: 10.1038/s41467-021-27239-y. Nat Commun. 2021. PMID: 34824277 Free PMC article.
A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity.
Meiser P, Knolle MA, Hirschberger A, de Almeida GP, Bayerl F, Lacher S, Pedde AM, Flommersfeld S, Hönninger J, Stark L, Stögbauer F, Anton M, Wirth M, Wohlleber D, Steiger K, Buchholz VR, Wollenberg B, Zielinski CE, Braren R, Rueckert D, Knolle PA, Kaissis G, Böttcher JP. Meiser P, et al. Among authors: wohlleber d. Cancer Cell. 2023 Aug 14;41(8):1498-1515.e10. doi: 10.1016/j.ccell.2023.06.008. Epub 2023 Jul 13. Cancer Cell. 2023. PMID: 37451271 Free article.
Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity.
Böttcher JP, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A, Höchst B, Hegenbarth S, Grell J, Limmer A, Atreya I, Neurath MF, Busch DH, Schmitt E, van Endert P, Kolanus W, Kurts C, Schultze JL, Diehl L, Knolle PA. Böttcher JP, et al. Among authors: wohlleber d. Cell Rep. 2013 Mar 28;3(3):779-95. doi: 10.1016/j.celrep.2013.02.008. Epub 2013 Mar 14. Cell Rep. 2013. PMID: 23499443 Free article.
Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.
Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn AM, Quast T, Koch K, Nehring M, König J, Zweynert A, Harms FL, Steiner N, Limmer A, Förster I, Berberich-Siebelt F, Knolle PA, Wohlleber D, Kolanus W, Beyer M, Schultze JL, Burgdorf S. Schuette V, et al. Among authors: wohlleber d. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10649-54. doi: 10.1073/pnas.1605885113. Epub 2016 Sep 6. Proc Natl Acad Sci U S A. 2016. PMID: 27601670 Free PMC article.
Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation.
Holland T, Wohlleber D, Marx S, Kreutzberg T, Vento-Asturias S, Schmitt-Mbamunyo C, Welz M, Janas M, Komander K, Eickhoff S, Brewitz A, Hasenberg M, Männ L, Gunzer M, Wilhelm C, Kastenmüller W, Knolle P, Abdullah Z, Kurts C, Garbi N. Holland T, et al. Among authors: wohlleber d. J Allergy Clin Immunol. 2018 Jan;141(1):416-419.e10. doi: 10.1016/j.jaci.2017.06.048. Epub 2017 Aug 19. J Allergy Clin Immunol. 2018. PMID: 28826775 No abstract available.
KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas.
Brockschmidt A, Trost D, Peterziel H, Zimmermann K, Ehrler M, Grassmann H, Pfenning PN, Waha A, Wohlleber D, Brockschmidt FF, Jugold M, Hoischen A, Kalla C, Waha A, Seifert G, Knolle PA, Latz E, Hans VH, Wick W, Pfeifer A, Angel P, Weber RG. Brockschmidt A, et al. Among authors: wohlleber d. Brain. 2012 Apr;135(Pt 4):1027-41. doi: 10.1093/brain/aws045. Epub 2012 Mar 16. Brain. 2012. PMID: 22427331
Analysis of Mitochondria by Single-Organelle Resolution.
Harbauer AB, Schneider A, Wohlleber D. Harbauer AB, et al. Among authors: wohlleber d. Annu Rev Anal Chem (Palo Alto Calif). 2022 Jun 13;15(1):1-16. doi: 10.1146/annurev-anchem-061020-111722. Epub 2022 Mar 18. Annu Rev Anal Chem (Palo Alto Calif). 2022. PMID: 35303775 Review.
Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses.
Bayerl F, Meiser P, Donakonda S, Hirschberger A, Lacher SB, Pedde AM, Hermann CD, Elewaut A, Knolle M, Ramsauer L, Rudolph TJ, Grassmann S, Öllinger R, Kirchhammer N, Trefny M, Anton M, Wohlleber D, Höchst B, Zaremba A, Krüger A, Rad R, Obenauf AC, Schadendorf D, Zippelius A, Buchholz VR, Schraml BU, Böttcher JP. Bayerl F, et al. Among authors: wohlleber d. Immunity. 2023 Jun 13;56(6):1341-1358.e11. doi: 10.1016/j.immuni.2023.05.011. Immunity. 2023. PMID: 37315536 Free article.
Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity.
Schirmer D, Grünewald TG, Klar R, Schmidt O, Wohlleber D, Rubío RA, Uckert W, Thiel U, Bohne F, Busch DH, Krackhardt AM, Burdach S, Richter GH. Schirmer D, et al. Among authors: wohlleber d. Oncoimmunology. 2016 Apr 25;5(6):e1175795. doi: 10.1080/2162402X.2016.1175795. eCollection 2016 Jun. Oncoimmunology. 2016. PMID: 27471654 Free PMC article.
RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.
Coch C, Stümpel JP, Lilien-Waldau V, Wohlleber D, Kümmerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E. Coch C, et al. Among authors: wohlleber d. Mol Ther. 2017 Sep 6;25(9):2093-2103. doi: 10.1016/j.ymthe.2017.07.003. Epub 2017 Jul 8. Mol Ther. 2017. PMID: 28760668 Free PMC article.
Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA.
Schrom E, Huber M, Aneja M, Dohmen C, Emrich D, Geiger J, Hasenpusch G, Herrmann-Janson A, Kretzschmann V, Mykhailyk O, Pasewald T, Oak P, Hilgendorff A, Wohlleber D, Hoymann HG, Schaudien D, Plank C, Rudolph C, Kubisch-Dohmen R. Schrom E, et al. Among authors: wohlleber d. Mol Ther Nucleic Acids. 2017 Jun 16;7:350-365. doi: 10.1016/j.omtn.2017.04.006. Epub 2017 Apr 13. Mol Ther Nucleic Acids. 2017. PMID: 28624211 Free PMC article.
Attenuated effector T cells are linked to control of chronic HBV infection.
Heim K, Sagar, Sogukpinar Ö, Llewellyn-Lacey S, Price DA, Emmerich F, Kraft ARM, Cornberg M, Kielbassa S, Knolle P, Wohlleber D, Bengsch B, Boettler T, Neumann-Haefelin C, Thimme R, Hofmann M. Heim K, et al. Among authors: wohlleber d. Nat Immunol. 2024 Sep;25(9):1650-1662. doi: 10.1038/s41590-024-01928-4. Epub 2024 Aug 28. Nat Immunol. 2024. PMID: 39198634 Free PMC article.
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection.
Bosch M, Kallin N, Donakonda S, Zhang JD, Wintersteller H, Hegenbarth S, Heim K, Ramirez C, Fürst A, Lattouf EI, Feuerherd M, Chattopadhyay S, Kumpesa N, Griesser V, Hoflack JC, Siebourg-Polster J, Mogler C, Swadling L, Pallett LJ, Meiser P, Manske K, de Almeida GP, Kosinska AD, Sandu I, Schneider A, Steinbacher V, Teng Y, Schnabel J, Theis F, Gehring AJ, Boonstra A, Janssen HLA, Vandenbosch M, Cuypers E, Öllinger R, Engleitner T, Rad R, Steiger K, Oxenius A, Lo WL, Klepsch V, Baier G, Holzmann B, Maini MK, Heeren R, Murray PJ, Thimme R, Herrmann C, Protzer U, Böttcher JP, Zehn D, Wohlleber D, Lauer GM, Hofmann M, Luangsay S, Knolle PA. Bosch M, et al. Among authors: wohlleber d. Nature. 2024 Jul;631(8022):867-875. doi: 10.1038/s41586-024-07630-7. Epub 2024 Jul 10. Nature. 2024. PMID: 38987588 Free PMC article.