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Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.
Haston S, Gonzalez-Gualda E, Morsli S, Ge J, Reen V, Calderwood A, Moutsopoulos I, Panousopoulos L, Deletic P, Carreno G, Guiho R, Manshaei S, Gonzalez-Meljem JM, Lim HY, Simpson DJ, Birch J, Pallikonda HA, Chandra T, Macias D, Doherty GJ, Rassl DM, Rintoul RC, Signore M, Mohorianu I, Akbar AN, Gil J, Muñoz-Espín D, Martinez-Barbera JP. Haston S, et al. Among authors: akbar an. Cancer Cell. 2023 Jul 10;41(7):1242-1260.e6. doi: 10.1016/j.ccell.2023.05.004. Epub 2023 Jun 1. Cancer Cell. 2023. PMID: 37267953 Free article.
Senescent T cells: Beneficial and detrimental roles.
Laphanuwat P, Gomes DCO, Akbar AN. Laphanuwat P, et al. Among authors: akbar an. Immunol Rev. 2023 Jul;316(1):160-175. doi: 10.1111/imr.13206. Epub 2023 Apr 25. Immunol Rev. 2023. PMID: 37098109 Free PMC article. Review.
Lesional senescent CD4+ T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis.
Covre LP, Fantecelle CH, Garcia de Moura R, Oliveira Lopes P, Sarmento IV, Freire-de-Lima CG, Decote-Ricardo D, de Matos Guedes HL, da Fonsceca-Martins AM, de Carvalho LP, de Carvalho EM, Mosser DM, Falqueto A, Akbar AN, Gomes DCO. Covre LP, et al. Among authors: akbar an. Front Immunol. 2024 Oct 21;15:1475146. doi: 10.3389/fimmu.2024.1475146. eCollection 2024. Front Immunol. 2024. PMID: 39497830 Free PMC article.
Epoxy-oxylipins direct monocyte fate in inflammatory resolution in humans.
Bracken OV, Jalali P, Glanville JRW, Benvenutti L, Chambers ES, Trahair H, Motwani M, Feehan KT, Evans JG, Carvalho JS, De Maeyer RPH, Akbar AN, Lih FB, Zeldin DC, Bishop-Bailey D, Edin ML, Gilroy DW. Bracken OV, et al. Among authors: akbar an. Nat Commun. 2026 Jan 16;17(1):431. doi: 10.1038/s41467-025-67961-5. Nat Commun. 2026. PMID: 41545341 Free PMC article.
Spatial profiling of human diffuse cutaneous leishmaniasis lesions reveals immunosuppressive microenvironments that coincide with parasite localization.
Lopes PO, Fantecelle CH, Barboza BA, Freire-de-Lima CG, Decote-Ricardo D, de Matos Guedes HL, da Fonseca-Martins AM, Carvalho LP, Boaventura VS, Mosser DM, Falqueto A, de Almeida ML, Coles M, Akbar AN, Borges VM, Covre LP, Gomes DCO. Lopes PO, et al. Among authors: akbar an. J Invest Dermatol. 2025 Nov 27:S0022-202X(25)03610-3. doi: 10.1016/j.jid.2025.10.617. Online ahead of print. J Invest Dermatol. 2025. PMID: 41317893 No abstract available.
212 results