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Modified AAV5 capsid for improved brain biodistribution following direct injection in preclinical models.
Kieper SN, Spronck EA, Bourajjaj M, Morais RDVS, van der Bent ML, Acar Broekmans S, van Rooijen C, van Westen R, Squeri G, Brasser G, Wartel M, Waaijer SJH, Hoornenborg CW, Hoogland TM, Porter R, Anggakusuma. Kieper SN, et al. Mol Ther Methods Clin Dev. 2025 Nov 14;33(4):101642. doi: 10.1016/j.omtm.2025.101642. eCollection 2025 Dec 11. Mol Ther Methods Clin Dev. 2025. PMID: 41399435 Free PMC article.
Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice.
Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Anggakusuma, Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Ströh LJ, Miskey C, Ivics Z, Herder V, Baumgärtner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T. Brown RJP, et al. Sci Adv. 2020 Nov 4;6(45):eabd3233. doi: 10.1126/sciadv.abd3233. Print 2020 Nov. Sci Adv. 2020. PMID: 33148654 Free PMC article.
C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle.
Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJP, Boldanova T, Zhang Y, Brüggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR, Heim MH, Sitek B, Bartenschlager R, Pietschmann T, Steinmann E. Kinast V, et al. J Hepatol. 2020 Sep;73(3):549-558. doi: 10.1016/j.jhep.2020.03.047. Epub 2020 Apr 12. J Hepatol. 2020. PMID: 32294532 Free article.
26 results