Brunotte L - Search Results

1

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS-CoV-2 infection in vitro.

Schloer S, Brunotte L, Mecate-Zambrano A, Zheng S, Tang J, Ludwig S, Rescher U. Schloer S, et al. Br J Pharmacol. 2021 Jun;178(11):2339-2350. doi: 10.1111/bph.15418. Epub 2021 Apr 6. Br J Pharmacol. 2021. PMID: 33825201 Free PMC article.

2

Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells.

Krischuns T, Günl F, Henschel L, Binder M, Willemsen J, Schloer S, Rescher U, Gerlt V, Zimmer G, Nordhoff C, Ludwig S, Brunotte L. Krischuns T, et al. Front Immunol. 2018 Sep 28;9:2229. doi: 10.3389/fimmu.2018.02229. eCollection 2018. Front Immunol. 2018. PMID: 30323812 Free PMC article.

3

The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo.

Schloer S, Goretzko J, Kühnl A, Brunotte L, Ludwig S, Rescher U. Schloer S, et al. Emerg Microbes Infect. 2019;8(1):80-93. doi: 10.1080/22221751.2018.1559709. Emerg Microbes Infect. 2019. PMID: 30866762 Free PMC article.

4

The annexin A1/FPR2 signaling axis expands alveolar macrophages, limits viral replication, and attenuates pathogenesis in the murine influenza A virus infection model.

Schloer S, Hübel N, Masemann D, Pajonczyk D, Brunotte L, Ehrhardt C, Brandenburg LO, Ludwig S, Gerke V, Rescher U. Schloer S, et al. FASEB J. 2019 Nov;33(11):12188-12199. doi: 10.1096/fj.201901265R. Epub 2019 Oct 2. FASEB J. 2019. PMID: 31398292 Free PMC article.

5

Type I interferon antagonistic properties of influenza B virus polymerase proteins.

Schreiber A, Liedmann S, Brunotte L, Anhlan D, Ehrhardt C, Ludwig S. Schreiber A, et al. Cell Microbiol. 2020 Feb;22(2):e13143. doi: 10.1111/cmi.13143. Epub 2019 Dec 8. Cell Microbiol. 2020. PMID: 31711273

6

Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities.

Matos ADR, Wunderlich K, Schloer S, Schughart K, Geffers R, Seders M, Witt M, Christersson A, Wiewrodt R, Wiebe K, Barth P, Hocke A, Hippenstiel S, Hönzke K, Dittmer U, Sutter K, Rescher U, Rodionycheva S, Matera N, Ludwig S, Brunotte L. Matos ADR, et al. Emerg Microbes Infect. 2019;8(1):1763-1776. doi: 10.1080/22221751.2019.1698271. Emerg Microbes Infect. 2019. PMID: 31826721 Free PMC article.

7

Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes.

Schreiber A, Boff L, Anhlan D, Krischuns T, Brunotte L, Schuberth C, Wedlich-Söldner R, Drexler H, Ludwig S. Schreiber A, et al. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16557-16566. doi: 10.1073/pnas.2002828117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601201 Free PMC article.

8

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine.

Schloer S, Brunotte L, Goretzko J, Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U. Schloer S, et al. Emerg Microbes Infect. 2020 Dec;9(1):2245-2255. doi: 10.1080/22221751.2020.1829082. Emerg Microbes Infect. 2020. PMID: 32975484 Free PMC article.

9

Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation.

Boff L, Schreiber A, da Rocha Matos A, Del Sarto J, Brunotte L, Munkert J, Melo Ottoni F, Silva Ramos G, Kreis W, Castro Braga F, José Alves R, Maia de Pádua R, Maria Oliveira Simões C, Ludwig S. Boff L, et al. Molecules. 2020 Oct 21;25(20):4853. doi: 10.3390/molecules25204853. Molecules. 2020. PMID: 33096707 Free PMC article.

10

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface.

Bertoglio F, Meier D, Langreder N, Steinke S, Rand U, Simonelli L, Heine PA, Ballmann R, Schneider KT, Roth KDR, Ruschig M, Riese P, Eschke K, Kim Y, Schäckermann D, Pedotti M, Kuhn P, Zock-Emmenthal S, Wöhrle J, Kilb N, Herz T, Becker M, Grasshoff M, Wenzel EV, Russo G, Kröger A, Brunotte L, Ludwig S, Fühner V, Krämer SD, Dübel S, Varani L, Roth G, Čičin-Šain L, Schubert M, Hust M. Bertoglio F, et al. Nat Commun. 2021 Mar 11;12(1):1577. doi: 10.1038/s41467-021-21609-2. Nat Commun. 2021. PMID: 33707427 Free PMC article.

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