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Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade.
Woess K, Macho-Maschler S, Van Ingen Schenau DS, Butler M, Lassnig C, Valcanover D, Poelzl A, Meissl K, Maurer B, Brandstoetter T, Vogl C, Koren A, Kubicek S, Orlova A, Moriggl R, Strobl B, Sexl V, Van Leeuwen FN, Kuiper RP, Mueller M. Woess K, et al. Among authors: butler m. Haematologica. 2023 Apr 1;108(4):993-1005. doi: 10.3324/haematol.2021.279848. Haematologica. 2023. PMID: 35021603 Free PMC article.
Amino Acid Depletion Therapies: Starving Cancer Cells to Death.
Butler M, van der Meer LT, van Leeuwen FN. Butler M, et al. Trends Endocrinol Metab. 2021 Jun;32(6):367-381. doi: 10.1016/j.tem.2021.03.003. Epub 2021 Mar 29. Trends Endocrinol Metab. 2021. PMID: 33795176 Free article. Review.
BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway.
Butler M, van Ingen Schenau DS, Yu J, Jenni S, Dobay MP, Hagelaar R, Vervoort BMT, Tee TM, Hoff FW, Meijerink JP, Kornblau SM, Bornhauser B, Bourquin JP, Kuiper RP, van der Meer LT, van Leeuwen FN. Butler M, et al. Blood. 2021 Dec 9;138(23):2383-2395. doi: 10.1182/blood.2021011787. Blood. 2021. PMID: 34280258 Free PMC article. Clinical Trial.
Combined inhibition of topoisomerase I and poly(ADP-ribose) polymerase: A synergistic therapeutic strategy for glioblastoma with phosphatase and tensin homolog deficiency.
Kim O, Butler M, Sergi Z, Robey RW, Zhang M, Chari R, Pang Y, Yu G, Zhang W, Song H, Davis D, Hawley RG, Wen X, Wang H, Quezado M, Tran B, Merchant M, Ranjan A, Furnari FB, Khan J, Gilbert MR, Ryan Miller C, Gottesman MM, Pommier Y, Wu J. Kim O, et al. Among authors: butler m. Neurooncol Adv. 2023 Aug 21;5(1):vdad102. doi: 10.1093/noajnl/vdad102. eCollection 2023 Jan-Dec. Neurooncol Adv. 2023. PMID: 37706203 Free PMC article.
Immune Checkpoint Inhibitors in Advanced Cutaneous Squamous Cell Carcinoma: Real-World Experience from a Canadian Comprehensive Cancer Centre.
Koch Hein EC, Vilbert M, Hirsch I, Fernando Ribeiro M, Muniz TP, Fournier C, Abdulalem K, Saldanha EF, Martinez E, Spreafico A, Hogg DH, Butler MO, Saibil SD. Koch Hein EC, et al. Among authors: butler mo. Cancers (Basel). 2023 Aug 29;15(17):4312. doi: 10.3390/cancers15174312. Cancers (Basel). 2023. PMID: 37686588 Free PMC article.
2,816 results