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SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation.
Bidault G, Virtue S, Petkevicius K, Jolin HE, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BYH, Ma MK, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ, Vidal-Puig A. Bidault G, et al. Nat Metab. 2021 Sep;3(9):1150-1162. doi: 10.1038/s42255-021-00440-5. Epub 2021 Sep 16. Nat Metab. 2021. PMID: 34531575 Free PMC article.
Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.
Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Carobbio S, et al. Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6. Diabetes. 2013. PMID: 23919961 Free PMC article.
The different shades of fat.
Peirce V, Carobbio S, Vidal-Puig A. Peirce V, et al. Nature. 2014 Jun 5;510(7503):76-83. doi: 10.1038/nature13477. Nature. 2014. PMID: 24899307 Review.
58 results