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GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.
Gandasi NR, Gao R, Kothegala L, Pearce A, Santos C, Acreman S, Basco D, Benrick A, Chibalina MV, Clark A, Guida C, Harris M, Johnson PRV, Knudsen JG, Ma J, Miranda C, Shigeto M, Tarasov AI, Yeung HY, Thorens B, Asterholm IW, Zhang Q, Ramracheya R, Ladds G, Rorsman P. Gandasi NR, et al. Among authors: clark a. Diabetologia. 2024 Mar;67(3):528-546. doi: 10.1007/s00125-023-06060-w. Epub 2023 Dec 21. Diabetologia. 2024. PMID: 38127123 Free PMC article.
Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.
Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E, Rorsman NJG, Martín-Del-Río R, Lewis A, Özkan G, Do HW, Spégel P, Saitoh K, Kato K, Igarashi K, Kessler BM, Pugh CW, Tamarit-Rodriguez J, Mulder H, Clark A, Frizzell N, Soga T, Ashcroft FM, Silver A, Pollard PJ, Rorsman P. Adam J, et al. Among authors: clark a. Cell Rep. 2017 Sep 26;20(13):3135-3148. doi: 10.1016/j.celrep.2017.08.093. Cell Rep. 2017. PMID: 28954230 Free PMC article.
Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism.
McLaughlin K, Acreman S, Nawaz S, Cutteridge J, Clark A, Knudsen JG, Denwood G, Spigelman AF, Manning Fox JE, Singh SP, MacDonald PE, Hastoy B, Zhang Q. McLaughlin K, et al. Among authors: clark a. Diabet Med. 2022 Dec;39(12):e14984. doi: 10.1111/dme.14984. Epub 2022 Oct 31. Diabet Med. 2022. PMID: 36264270 Free PMC article.
7,918 results