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Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase.
Nat Commun. 2022 Jan 24;13(1):459. doi: 10.1038/s41467-022-28108-y.
Nat Commun. 2022.
PMID: 35075105
Free PMC article.
Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase.
Vinayak S, Jumani RS, Miller P, Hasan MM, McLeod BI, Tandel J, Stebbins EE, Teixeira JE, Borrel J, Gonse A, Zhang M, Yu X, Wernimont A, Walpole C, Eckley S, Love MS, McNamara CW, Sharma M, Sharma A, Scherer CA, Kato N, Schreiber SL, Melillo B, Striepen B, Huston CD, Comer E.
Vinayak S, et al. Among authors: gonse a.
Sci Transl Med. 2020 Sep 30;12(563):eaba8412. doi: 10.1126/scitranslmed.aba8412.
Sci Transl Med. 2020.
PMID: 32998973
Free PMC article.
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Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.
Sharma M, Malhotra N, Yogavel M, Harlos K, Melillo B, Comer E, Gonse A, Parvez S, Mitasev B, Fang FG, Schreiber SL, Sharma A.
Sharma M, et al. Among authors: gonse a.
Nat Commun. 2021 Jan 12;12(1):343. doi: 10.1038/s41467-020-20478-5.
Nat Commun. 2021.
PMID: 33436639
Free PMC article.
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Combining recombinase polymerase amplification and DNA-templated reaction for SARS-CoV-2 sensing with dual fluorescence and lateral flow assay output.
Farrera-Soler L, Gonse A, Kim KT, Barluenga S, Winssinger N.
Farrera-Soler L, et al. Among authors: gonse a.
Biopolymers. 2022 Apr;113(4):e23485. doi: 10.1002/bip.23485. Epub 2022 Jan 13.
Biopolymers. 2022.
PMID: 35023571
Free PMC article.
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Dual Bcl-XL /Bcl-2 inhibitors discovered from DNA-encoded libraries using a fragment pairing strategy.
Daguer JP, Gonse A, Shchukin Y, Farrera-Soler L, Barluenga S, Winssinger N.
Daguer JP, et al. Among authors: gonse a.
Bioorg Med Chem. 2021 Aug 15;44:116282. doi: 10.1016/j.bmc.2021.116282. Epub 2021 Jun 24.
Bioorg Med Chem. 2021.
PMID: 34216984
Free article.
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