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14 results

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Page 1
Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library.
Shell DJ, Rectenwald JM, Buttery PH, Johnson RL, Foley CA, Guduru SKR, Uguen M, Rubiano JS, Zhang X, Li F, Norris-Drouin JL, Axtman M, Brian Hardy P, Vedadi M, Frye SV, James LI, Pearce KH. Shell DJ, et al. Among authors: guduru skr. SLAS Discov. 2022 Dec;27(8):428-439. doi: 10.1016/j.slasd.2022.10.003. Epub 2022 Oct 19. SLAS Discov. 2022. PMID: 36272689 Free article.
Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology.
Potjewyd FM, Annor-Gyamfi JK, Aubé J, Chu S, Conlon IL, Frankowski KJ, Guduru SKR, Hardy BP, Hopkins MD, Kinoshita C, Kireev DB, Mason ER, Moerk CT, Nwogbo F, Pearce KH Jr, Richardson TI, Rogers DA, Soni DM, Stashko M, Wang X, Wells C, Willson TM, Frye SV, Young JE, Axtman AD. Potjewyd FM, et al. Among authors: guduru skr. Alzheimers Dement (N Y). 2022 Apr 12;8(1):e12253. doi: 10.1002/trc2.12253. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 35434254 Free PMC article.
AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery.
Potjewyd FM, Annor-Gyamfi JK, Aubé J, Chu S, Conlon IL, Frankowski KJ, Guduru SKR, Hardy BP, Hopkins MD, Kinoshita C, Kireev DB, Mason ER, Moerk CT, Nwogbo F, Pearce KH, Richardson TI, Rogers DA, Soni DM, Stashko M, Wang X, Wells C, Willson TM, Frye SV, Young JE, Axtman AD. Potjewyd FM, et al. Among authors: guduru skr. Alzheimers Dement (N Y). 2022 Apr 20;8(1):e12246. doi: 10.1002/trc2.12246. eCollection 2022. Alzheimers Dement (N Y). 2022. PMID: 35475262 Free PMC article.
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.
Shell DJ, Foley CA, Wang Q, Smith CM, Guduru SKR, Zeng H, Dong A, Norris-Drouin JL, Axtman M, Hardy PB, Gupta G, Halabelian L, Frye SV, James LI, Pearce KH. Shell DJ, et al. Among authors: guduru skr. J Med Chem. 2023 Oct 26;66(20):14133-14149. doi: 10.1021/acs.jmedchem.3c01192. Epub 2023 Oct 2. J Med Chem. 2023. PMID: 37782247 Free PMC article.
A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells.
Song F, Tsahouridis O, Stucchi S, Walhart T, Mendell S, Hardy PB, Axtman M, Guduru SKR, Gilbert TSK, Graves LM, Herring LE, Savoldo B, Ma X, Woodcock M, Milner JJ, Ivanova A, Pearce KH, Xu Y, Dotti G. Song F, et al. Among authors: guduru skr. Nat Immunol. 2025 Feb;26(2):279-293. doi: 10.1038/s41590-024-02042-1. Epub 2025 Jan 8. Nat Immunol. 2025. PMID: 39779871 Free PMC article.
Discovery of Novel TYRO3/MERTK Dual Inhibitors.
Kong D, Zhao J, Huang D, Stashko MA, Yan D, Ding R, Guduru SKR, Zhou Y, Kania CE, Shelton Earp H 3rd, Frye SV, Huelse JM, Kireev D, DeRyckere D, Graham DK, Wang X. Kong D, et al. Among authors: guduru skr. J Med Chem. 2025 Apr 24;68(8):8455-8470. doi: 10.1021/acs.jmedchem.5c00009. Epub 2025 Apr 11. J Med Chem. 2025. PMID: 40215328 Free PMC article.
Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery.
Chang L, Campbell J, Raji IO, Guduru SKR, Kandel P, Nguyen M, Liu S, Tran K, Venugopal NK, Taylor BC, Holt MV, Young NL, Samuel ELG, Jain P, Santini C, Sankaran B, MacKenzie KR, Young DW. Chang L, et al. Among authors: guduru skr. Sci Rep. 2021 Jan 13;11(1):1121. doi: 10.1038/s41598-020-80588-4. Sci Rep. 2021. PMID: 33441849 Free PMC article.
14 results