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The Combination of Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Delays KMT2A-Rearranged Leukemia Progression.
Xiao L, Karsa M, Ronca E, Bongers A, Kosciolek A, El-Ayoubi A, Revalde JL, Seneviratne JA, Cheung BB, Cheung LC, Kotecha RS, Newbold A, Bjelosevic S, Arndt GM, Lock RB, Johnstone RW, Gudkov AV, Gurova KV, Haber M, Norris MD, Henderson MJ, Somers K. Xiao L, et al. Among authors: gurova kv. Front Oncol. 2022 May 23;12:863329. doi: 10.3389/fonc.2022.863329. eCollection 2022. Front Oncol. 2022. PMID: 35677155 Free PMC article.
Alkaloid-rich fraction of Ervatamia coronaria sensitizes colorectal cancer through modulating AMPK and mTOR signalling pathways.
Dutta N, Pemmaraju DB, Ghosh S, Ali A, Mondal A, Majumder C, Nelson VK, Mandal SC, Misra AK, Rengan AK, Ravichandiran V, Che CT, Gurova KV, Gudkov AV, Pal M. Dutta N, et al. Among authors: gurova kv. J Ethnopharmacol. 2022 Jan 30;283:114666. doi: 10.1016/j.jep.2021.114666. Epub 2021 Sep 27. J Ethnopharmacol. 2022. PMID: 34592338
Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma.
Xiao L, Somers K, Murray J, Pandher R, Karsa M, Ronca E, Bongers A, Terry R, Ehteda A, Gamble LD, Issaeva N, Leonova KI, O'Connor A, Mayoh C, Venkat P, Quek H, Brand J, Kusuma FK, Pettitt JA, Mosmann E, Kearns A, Eden G, Alfred S, Allan S, Zhai L, Kamili A, Gifford AJ, Carter DR, Henderson MJ, Fletcher JI, Marshall G, Johnstone RW, Cesare AJ, Ziegler DS, Gudkov AV, Gurova KV, Norris MD, Haber M. Xiao L, et al. Among authors: gurova kv. Clin Cancer Res. 2021 Aug 1;27(15):4338-4352. doi: 10.1158/1078-0432.CCR-20-2357. Epub 2021 May 16. Clin Cancer Res. 2021. PMID: 33994371 Free PMC article.
Stimulation of an anti-tumor immune response with "chromatin-damaging" therapy.
Chen M, Brackett CM, Burdelya LG, Punnanitinont A, Patnaik SK, Matsuzaki J, Odunsi AO, Gudkov AV, Singh AK, Repasky EA, Gurova KV. Chen M, et al. Among authors: gurova kv. Cancer Immunol Immunother. 2021 Jul;70(7):2073-2086. doi: 10.1007/s00262-020-02846-8. Epub 2021 Jan 13. Cancer Immunol Immunother. 2021. PMID: 33439292
The 3D Genome as a Target for Anticancer Therapy.
Kantidze OL, Gurova KV, Studitsky VM, Razin SV. Kantidze OL, et al. Among authors: gurova kv. Trends Mol Med. 2020 Feb;26(2):141-149. doi: 10.1016/j.molmed.2019.09.011. Epub 2019 Oct 31. Trends Mol Med. 2020. PMID: 31679987 Review.
Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling.
Kirsanov K, Fetisov T, Lesovaya EA, Maksimova V, Trukhanova L, Antoshina E, Gor'kova T, Morozova O, Safina A, Fleyshman D, Salimov R, Shipaeva E, Ivanov R, Leonov A, Purmal AA, Belitsky GA, Gudkov AV, Gurova KV, Yakubovskaya MG. Kirsanov K, et al. Among authors: gurova kv. Cancer Prev Res (Phila). 2020 Jan;13(1):53-64. doi: 10.1158/1940-6207.CAPR-19-0198. Epub 2019 Oct 25. Cancer Prev Res (Phila). 2020. PMID: 31653646
The anti-cancer drugs curaxins target spatial genome organization.
Kantidze OL, Luzhin AV, Nizovtseva EV, Safina A, Valieva ME, Golov AK, Velichko AK, Lyubitelev AV, Feofanov AV, Gurova KV, Studitsky VM, Razin SV. Kantidze OL, et al. Among authors: gurova kv. Nat Commun. 2019 Mar 29;10(1):1441. doi: 10.1038/s41467-019-09500-7. Nat Commun. 2019. PMID: 30926878 Free PMC article.
46 results