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Prevention of Chromatin Destabilization by FACT Is Crucial for Malignant Transformation.
Sandlesh P, Safina A, Goswami I, Prendergast L, Rosario S, Gomez EC, Wang J, Gurova KV. Sandlesh P, et al. Among authors: gurova kv. iScience. 2020 Jun 26;23(6):101177. doi: 10.1016/j.isci.2020.101177. Epub 2020 May 18. iScience. 2020. PMID: 32498018 Free PMC article.
A Translational Hepatic Artery Infusion (HAI) Model for Hepatocellular Carcinoma in Woodchucks.
Kim M, Powers CA, Curtin LI, Fisher DT, Sexton S, Gurova KV, Skitzki JJ, Iyer RV. Kim M, et al. Among authors: gurova kv. J Surg Res. 2020 Jul;251:126-136. doi: 10.1016/j.jss.2020.02.002. Epub 2020 Mar 3. J Surg Res. 2020. PMID: 32143057
Histone Chaperone FACT and Curaxins: Effects on Genome Structure and Function.
Chang HW, Nizovtseva EV, Razin SV, Formosa T, Gurova KV, Studitsky VM. Chang HW, et al. Among authors: gurova kv. J Cancer Metastasis Treat. 2019;5:78. doi: 10.20517/2394-4722.2019.31. Epub 2019 Nov 29. J Cancer Metastasis Treat. 2019. PMID: 31853507 Free PMC article.
The 3D Genome as a Target for Anticancer Therapy.
Kantidze OL, Gurova KV, Studitsky VM, Razin SV. Kantidze OL, et al. Among authors: gurova kv. Trends Mol Med. 2020 Feb;26(2):141-149. doi: 10.1016/j.molmed.2019.09.011. Epub 2019 Oct 31. Trends Mol Med. 2020. PMID: 31679987 Review.
Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling.
Kirsanov K, Fetisov T, Lesovaya EA, Maksimova V, Trukhanova L, Antoshina E, Gor'kova T, Morozova O, Safina A, Fleyshman D, Salimov R, Shipaeva E, Ivanov R, Leonov A, Purmal AA, Belitsky GA, Gudkov AV, Gurova KV, Yakubovskaya MG. Kirsanov K, et al. Among authors: gurova kv. Cancer Prev Res (Phila). 2020 Jan;13(1):53-64. doi: 10.1158/1940-6207.CAPR-19-0198. Epub 2019 Oct 25. Cancer Prev Res (Phila). 2020. PMID: 31653646
The anti-cancer drugs curaxins target spatial genome organization.
Kantidze OL, Luzhin AV, Nizovtseva EV, Safina A, Valieva ME, Golov AK, Velichko AK, Lyubitelev AV, Feofanov AV, Gurova KV, Studitsky VM, Razin SV. Kantidze OL, et al. Among authors: gurova kv. Nat Commun. 2019 Mar 29;10(1):1441. doi: 10.1038/s41467-019-09500-7. Nat Commun. 2019. PMID: 30926878 Free PMC article.
Chromatin Stability as a Target for Cancer Treatment.
Gurova KV. Gurova KV. Bioessays. 2019 Jan;41(1):e1800141. doi: 10.1002/bies.201800141. Bioessays. 2019. PMID: 30566250 Free PMC article. Review.
Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins.
Chang HW, Valieva ME, Safina A, Chereji RV, Wang J, Kulaeva OI, Morozov AV, Kirpichnikov MP, Feofanov AV, Gurova KV, Studitsky VM. Chang HW, et al. Among authors: gurova kv. Sci Adv. 2018 Nov 7;4(11):eaav2131. doi: 10.1126/sciadv.aav2131. eCollection 2018 Nov. Sci Adv. 2018. PMID: 30417101 Free PMC article.
Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene.
Sandlesh P, Juang T, Safina A, Higgins MJ, Gurova KV. Sandlesh P, et al. Among authors: gurova kv. PLoS One. 2018 Jun 28;13(6):e0199785. doi: 10.1371/journal.pone.0199785. eCollection 2018. PLoS One. 2018. PMID: 29953487 Free PMC article.
Role of Chromatin Damage and Chromatin Trapping of FACT in Mediating the Anticancer Cytotoxicity of DNA-Binding Small-Molecule Drugs.
Nesher E, Safina A, Aljahdali I, Portwood S, Wang ES, Koman I, Wang J, Gurova KV. Nesher E, et al. Among authors: gurova kv. Cancer Res. 2018 Mar 15;78(6):1431-1443. doi: 10.1158/0008-5472.CAN-17-2690. Epub 2018 Jan 16. Cancer Res. 2018. PMID: 29339544 Free PMC article.
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