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Charting cellular identity during human in vitro β-cell differentiation.
Veres A, Faust AL, Bushnell HL, Engquist EN, Kenty JH, Harb G, Poh YC, Sintov E, Gürtler M, Pagliuca FW, Peterson QP, Melton DA. Veres A, et al. Among authors: Harb G. Nature. 2019 May;569(7756):368-373. doi: 10.1038/s41586-019-1168-5. Epub 2019 May 8. Nature. 2019. PMID: 31068696 Free PMC article.
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.
Shen W, Taylor B, Jin Q, Nguyen-Tran V, Meeusen S, Zhang YQ, Kamireddy A, Swafford A, Powers AF, Walker J, Lamb J, Bursalaya B, DiDonato M, Harb G, Qiu M, Filippi CM, Deaton L, Turk CN, Suarez-Pinzon WL, Liu Y, Hao X, Mo T, Yan S, Li J, Herman AE, Hering BJ, Wu T, Martin Seidel H, McNamara P, Glynne R, Laffitte B. Shen W, et al. Nat Commun. 2015 Oct 26;6:8372. doi: 10.1038/ncomms9372. Nat Commun. 2015. PMID: 26496802 Free PMC article.
Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells.
Wang P, Karakose E, Liu H, Swartz E, Ackeifi C, Zlatanic V, Wilson J, González BJ, Bender A, Takane KK, Ye L, Harb G, Pagliuca F, Homann D, Egli D, Argmann C, Scott DK, Garcia-Ocaña A, Stewart AF. Wang P, et al. Among authors: Harb G. Cell Metab. 2019 Mar 5;29(3):638-652.e5. doi: 10.1016/j.cmet.2018.12.005. Epub 2018 Dec 20. Cell Metab. 2019. PMID: 30581122 Free PMC article.
Acute exposure to streptozotocin but not human proinflammatory cytokines impairs neonatal porcine islet insulin secretion in vitro but not in vivo.
Harb G, Toreson J, Dufour J, Korbutt G. Harb G, et al. Xenotransplantation. 2007 Nov;14(6):580-90. doi: 10.1111/j.1399-3089.2007.00427.x. Xenotransplantation. 2007. PMID: 17991146
Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression.
Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, Williams K, Zhang XY, Takane KK, Zhang P, Scott DK, Stewart AF, Garcia-Ocaña A, Vasavada RC. Guthalu Kondegowda N, et al. Diabetes. 2010 Dec;59(12):3131-8. doi: 10.2337/db09-1796. Epub 2010 Sep 28. Diabetes. 2010. PMID: 20876711 Free PMC article.
Small-molecule inducer of β cell proliferation identified by high-throughput screening.
Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang YQ, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Cho CY, Li J, Laffitte BA, McNamara P, Glynne R, Wu X, Herman AE, Schultz PG. Shen W, et al. J Am Chem Soc. 2013 Feb 6;135(5):1669-72. doi: 10.1021/ja309304m. Epub 2013 Jan 25. J Am Chem Soc. 2013. PMID: 23330637
Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels.
Webster NJ, Searle GJ, Lam PP, Huang YC, Riedel MJ, Harb G, Gaisano HY, Holt A, Light PE. Webster NJ, et al. Endocrinology. 2008 Jul;149(7):3679-87. doi: 10.1210/en.2007-1138. Epub 2008 Mar 27. Endocrinology. 2008. PMID: 18372336
Prolonged survival of microencapsulated neonatal porcine islet xenografts in immune-competent mice without antirejection therapy.
Kobayashi T, Arefanian H, Harb G, Tredget EB, Rajotte RV, Korbutt GS, Rayat GR. Kobayashi T, et al. Cell Transplant. 2008;17(10-11):1243-56. doi: 10.3727/096368908787236602. Cell Transplant. 2008. PMID: 19181218
Marginal mass islet transplantation with autologous mesenchymal stem cells promotes long-term islet allograft survival and sustained normoglycemia.
Solari MG, Srinivasan S, Boumaza I, Unadkat J, Harb G, Garcia-Ocana A, Feili-Hariri M. Solari MG, et al. J Autoimmun. 2009 Mar;32(2):116-24. doi: 10.1016/j.jaut.2009.01.003. Epub 2009 Feb 12. J Autoimmun. 2009. PMID: 19217258
Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts.
Kobayashi T, Harb G, Rajotte RV, Korbutt GS, Mallett AG, Arefanian H, Mok D, Rayat GR. Kobayashi T, et al. Xenotransplantation. 2006 Nov;13(6):547-59. doi: 10.1111/j.1399-3089.2006.00349.x. Xenotransplantation. 2006. PMID: 17059582
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