Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1.
He X, Wang QX, Wei D, Lin Y, Zhang X, Wu Y, Qian X, Lin Z, Xiao B, Wu Q, Wang Z, Zhou F, Wei Z, Wang J, Gong R, Zhang R, Zhang Q, Ding K, Gao S, Kang T.
He X, et al.
Cell Res. 2025 Apr 21. doi: 10.1038/s41422-025-01110-x. Online ahead of print.
Cell Res. 2025.
PMID: 40259053