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MicroRNAs in epilepsy: pathophysiology and clinical utility.
Henshall DC, Hamer HM, Pasterkamp RJ, Goldstein DB, Kjems J, Prehn JHM, Schorge S, Lamottke K, Rosenow F. Henshall DC, et al. Lancet Neurol. 2016 Dec;15(13):1368-1376. doi: 10.1016/S1474-4422(16)30246-0. Lancet Neurol. 2016. PMID: 27839653 Review.
Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy.
Reschke CR, Silva LFA, Norwood BA, Senthilkumar K, Morris G, Sanz-Rodriguez A, Conroy RM, Costard L, Neubert V, Bauer S, Farrell MA, O'Brien DF, Delanty N, Schorge S, Pasterkamp RJ, Rosenow F, Henshall DC. Reschke CR, et al. Among authors: henshall dc. Mol Ther Nucleic Acids. 2017 Mar 17;6:45-56. doi: 10.1016/j.omtn.2016.11.002. Epub 2016 Dec 10. Mol Ther Nucleic Acids. 2017. PMID: 28325299 Free PMC article.
Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy.
Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC. Raoof R, et al. Among authors: henshall dc. EBioMedicine. 2018 Dec;38:127-141. doi: 10.1016/j.ebiom.2018.10.068. Epub 2018 Nov 2. EBioMedicine. 2018. PMID: 30396857 Free PMC article.
Antagonizing Increased miR-135a Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures.
Vangoor VR, Reschke CR, Senthilkumar K, van de Haar LL, de Wit M, Giuliani G, Broekhoven MH, Morris G, Engel T, Brennan GP, Conroy RM, van Rijen PC, Gosselaar PH, Schorge S, Schaapveld RQJ, Henshall DC, De Graan PNE, Pasterkamp RJ. Vangoor VR, et al. Among authors: henshall dc. J Neurosci. 2019 Jun 26;39(26):5064-5079. doi: 10.1523/JNEUROSCI.3014-18.2019. Epub 2019 Apr 23. J Neurosci. 2019. PMID: 31015341 Free PMC article.
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.
Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti B, Vangoor VR, Sanz-Rodriguez A, Muilu J, Fabene PF, Pasterkamp RJ, Prehn JHM, Schorge S, Andersen JS, Rosenow F, Bauer S, Kjems J, Henshall DC. Venø MT, et al. Among authors: henshall dc. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15977-15988. doi: 10.1073/pnas.1919313117. Epub 2020 Jun 24. Proc Natl Acad Sci U S A. 2020. PMID: 32581127 Free PMC article.
233 results