Holt JR - Search Results

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316 results

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Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

Shubina-Oleinik O, Nist-Lund C, French C, Rockowitz S, Shearer AE, Holt JR. Shubina-Oleinik O, et al. Among authors: holt jr. Sci Adv. 2021 Dec 17;7(51):eabi7629. doi: 10.1126/sciadv.abi7629. Epub 2021 Dec 15. Sci Adv. 2021. PMID: 34910522 Free PMC article.

Emerging Gene Therapies for Genetic Hearing Loss.

Ahmed H, Shubina-Oleinik O, Holt JR. Ahmed H, et al. Among authors: holt jr. J Assoc Res Otolaryngol. 2017 Oct;18(5):649-670. doi: 10.1007/s10162-017-0634-8. Epub 2017 Aug 16. J Assoc Res Otolaryngol. 2017. PMID: 28815315 Free PMC article. Review.

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1.

Asai Y, Pan B, Nist-Lund C, Galvin A, Lukashkin AN, Lukashkina VA, Chen T, Zhou W, Zhu H, Russell IJ, Holt JR, Géléoc GSG. Asai Y, et al. Among authors: holt jr. Sci Rep. 2018 Aug 14;8(1):12124. doi: 10.1038/s41598-018-28958-x. Sci Rep. 2018. PMID: 30108254 Free PMC article.

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.

Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. Pan B, et al. Among authors: holt jr. Neuron. 2018 Aug 22;99(4):736-753.e6. doi: 10.1016/j.neuron.2018.07.033. Neuron. 2018. PMID: 30138589 Free PMC article.

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Nist-Lund CA, et al. Among authors: holt jr. Nat Commun. 2019 Jan 22;10(1):236. doi: 10.1038/s41467-018-08264-w. Nat Commun. 2019. PMID: 30670701 Free PMC article.

Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Nist-Lund CA, et al. Among authors: holt jr. Nat Commun. 2019 Feb 8;10(1):734. doi: 10.1038/s41467-019-08716-x. Nat Commun. 2019. PMID: 30737404 Free PMC article.

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.

György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP. György B, et al. Among authors: holt jr. Nat Med. 2019 Jul;25(7):1123-1130. doi: 10.1038/s41591-019-0500-9. Epub 2019 Jul 3. Nat Med. 2019. PMID: 31270503 Free PMC article.

Continuous evolution of base editors with expanded target compatibility and improved activity.

Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR. Thuronyi BW, et al. Among authors: holt jr. Nat Biotechnol. 2019 Sep;37(9):1070-1079. doi: 10.1038/s41587-019-0193-0. Epub 2019 Jul 22. Nat Biotechnol. 2019. PMID: 31332326 Free PMC article.

Publisher Correction: Continuous evolution of base editors with expanded target compatibility and improved activity.

Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR. Thuronyi BW, et al. Among authors: holt jr. Nat Biotechnol. 2019 Sep;37(9):1091. doi: 10.1038/s41587-019-0253-5. Nat Biotechnol. 2019. PMID: 31406330

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B.

Lee J, Nist-Lund C, Solanes P, Goldberg H, Wu J, Pan B, Schneider BL, Holt JR. Lee J, et al. Among authors: holt jr. Hear Res. 2020 Sep 1;394:107882. doi: 10.1016/j.heares.2020.107882. Epub 2020 Jan 13. Hear Res. 2020. PMID: 31980281 Free article.

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