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Page 1
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.
Giese APJ, Weng WH, Kindt KS, Chang HHV, Montgomery JS, Ratzan EM, Beirl AJ, Rivera RA, Lotthammer JM, Walujkar S, Foster MP, Zobeiri OA, Holt JR, Riazuddin S, Cullen KE, Sotomayor M, Ahmed ZM. Giese APJ, et al. Among authors: holt jr. bioRxiv [Preprint]. 2024 Jul 5:2023.05.26.542533. doi: 10.1101/2023.05.26.542533. bioRxiv. 2024. Update in: Elife. 2025 Jan 08;12:RP89719. doi: 10.7554/eLife.89719. PMID: 37398045 Free PMC article. Updated. Preprint.
Endocochlear potential contributes to hair cell death in TMPRSS3 hearing loss.
Shearer AE, Chen YS, Rouse SL, Wang X, Marin Fermin J, Booth KT, Moawad J, Libiran NB, Li J, Kim HY, Hoa M, Olszewski R, Lei JY, Cabrera E, Totten DJ, Zhao B, Holt JR, Nelson RF. Shearer AE, et al. Among authors: holt jr. J Clin Invest. 2025 Jul 17;135(18):e186395. doi: 10.1172/JCI186395. eCollection 2025 Sep 16. J Clin Invest. 2025. PMID: 40674144 Free PMC article.
TMEM145 is a principal component of outer hair cell stereocilia.
Derstroff D, Flook M, Löhnes A, Kreye P, Newton S, Renigunta V, Hanemaaijer S, Aguilar C, Holt JR, Bowl MR, Oliver D, Reimann K. Derstroff D, et al. Among authors: holt jr. Neuron. 2026 Mar 31:S0896-6273(26)00171-6. doi: 10.1016/j.neuron.2026.03.007. Online ahead of print. Neuron. 2026. PMID: 41923617 Free PMC article.
Molecular earplugs to protect the inner ear.
Chaves MG, Holt JR. Chaves MG, et al. Among authors: holt jr. Mol Ther Methods Clin Dev. 2023 Apr 26;29:284-285. doi: 10.1016/j.omtm.2023.04.001. eCollection 2023 Jun 8. Mol Ther Methods Clin Dev. 2023. PMID: 37168274 Free PMC article. No abstract available.
AAV-mediated exon skipping therapy for Usher syndrome, type 2A.
Mauriac SA, Lee J, Zhang J, Jin J, Nist-Lund C, Martin CT, Von Muhlenbrock CR, O'Malley S, Chaves MG, Madison MA, Foster K, Long S, Jacobs C, Kumar SR, Ramirez S, Ichida J, Koehler KR, Holt JR, Géléoc GSG. Mauriac SA, et al. Among authors: holt jr. Mol Ther. 2026 Jan 7;34(1):179-202. doi: 10.1016/j.ymthe.2025.09.038. Epub 2025 Sep 23. Mol Ther. 2026. PMID: 40994011
342 results