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Page 1
Pain has limited predictive value for fractures following falls in older people: insight from a retrospective study.
Pedersen V, Lampart A, Wania R, Arnold I, Maeder N, Niedermeier S, Stahl R, Trumm C, Kammerlander C, Boecker W, Nickel CH, Bingisser R, Klein M. Pedersen V, et al. BMC Emerg Med. 2026 Jun 16;26(1):176. doi: 10.1186/s12873-026-01644-2. BMC Emerg Med. 2026. PMID: 42304236 Free article.
BACKGROUND: In the emergency department (ED), decisions regarding radiological imaging for older patients who have experienced low-energy falls (LEF) are frequently complicated by inconsistencies between the reported mechanism of injury, the patients' symptoms, and the fin …
BACKGROUND: In the emergency department (ED), decisions regarding radiological imaging for older patients who have experienced low-energy fa …
Testican-1 activates Wnt/β-Catenin signaling to drive colorectal cancer progression.
Li Y, Huang C, Zhang C, Feng L, Lin H, Yao J, Luo S, Shi J, Yang Y, Cao Z, Weygant N. Li Y, et al. Oncogenesis. 2026 Jun 12. doi: 10.1038/s41389-026-00635-z. Online ahead of print. Oncogenesis. 2026. PMID: 42285945 Free article.
Testican-1 downregulation inhibited beta-catenin nuclear translocation and TCF/LEF-mediated transcription, leading to concurrent suppression of CRC proliferation and spheroid-forming potential. Conversely, Testican-1 overexpression promoted beta-catenin nuclear translocati …
Testican-1 downregulation inhibited beta-catenin nuclear translocation and TCF/LEF-mediated transcription, leading to concurrent supp …
Extracorporeal photopheresis versus systemic immunosuppression for treatment of immune-related adverse events: clinical outcomes from the prospective two-arm PRIA study.
Wein L, Ertl C, Ruf T, Morak M, Wang Y, Schmitt C, Garza Vazquez X, Glatzel V, David-Rus R, Mitwalli M, Srour J, Schöpf P, Tomsitz D, French LE, Heinzerling L. Wein L, et al. J Immunother Cancer. 2026 Jun 12;14(6):e015185. doi: 10.1136/jitc-2026-015185. J Immunother Cancer. 2026. PMID: 42285609 Free article.
Differential Wnt/β-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes.
Kluiver TA, Nordin A, Lu Y, Guo X, Schubert SA, Yeung D, Ardisasmita AI, Terpstra W, Zhang C, Duan X, Savur R, van den Heuvel MC, de Meijer VE, de Kleine RH, Kraal K, de Krijger RR, Zsiros J, Cantù C, Peng WC. Kluiver TA, et al. Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2528450123. doi: 10.1073/pnas.2528450123. Epub 2026 Jun 10. Proc Natl Acad Sci U S A. 2026. PMID: 42268900 Free PMC article.
Using CUT&RUN, we show that beta-catenin engages distinct genomic regions, dictated by differential association with TCF/LEF family transcription factors. Specifically, we define a sequence-specific regulatory element engaged by beta-catenin only upon interaction with …
Using CUT&RUN, we show that beta-catenin engages distinct genomic regions, dictated by differential association with TCF/LEF fami …
β-Catenin Does Not Co-activate Vitamin D Receptor-mediated Transcription in Osteoblastic and Non-osteoblastic Cells.
Nguyen TT, Kanemoto Y, Sawada T, Zhang J, Kurokawa T, Kato S. Nguyen TT, et al. Biosci Biotechnol Biochem. 2026 Jun 9:zbag084. doi: 10.1093/bbb/zbag084. Online ahead of print. Biosci Biotechnol Biochem. 2026. PMID: 42264460
Reporter assays were performed in Saos-2 osteoblastic cells using vitamin D response element (VDRE) and TCF/LEF-responsive reporters. Activation of Wnt signaling by CHIR99021 or expression of constitutively active beta-catenin did not enhance VDR transcriptional activity b …
Reporter assays were performed in Saos-2 osteoblastic cells using vitamin D response element (VDRE) and TCF/LEF-responsive reporters. …
DPP-Mediated Interaction of TAZ/β-Catenin Promotes the Differentiation of DPSCs into Odontoblasts.
Chen Y, Petho A, Ganapathy A, Bakthavachalam V, Villani C, George A. Chen Y, et al. Int J Mol Sci. 2026 May 20;27(10):4599. doi: 10.3390/ijms27104599. Int J Mol Sci. 2026. PMID: 42196576 Free PMC article.
Some of these genes also contain binding sites for the TCF/LEF transcription factors that interact with the Wnt effector, beta-catenin. Activation of TAZ and beta-catenin resulted in the upregulation of odontoblast gene expression and reduced expression in the presence of …
Some of these genes also contain binding sites for the TCF/LEF transcription factors that interact with the Wnt effector, beta-cateni …
Egg yolk phospholipid peptides as dual-functional nanocarriers for curcumin: Enhanced hypolipidemic effects and mechanism.
Zhang R, Feng W, Jiang L, Chang C, Gu L, Su Y, Yang Y, Wang Y, Li J. Zhang R, et al. Food Res Int. 2026 Aug 1;237:119325. doi: 10.1016/j.foodres.2026.119325. Epub 2026 May 2. Food Res Int. 2026. PMID: 42169288
Additionally, the screened EYPP-derived peptide fragment LEF was verified to bind stably to LDLR and cholesterol esterase via hydrogen bonding and electrostatic interactions. ...
Additionally, the screened EYPP-derived peptide fragment LEF was verified to bind stably to LDLR and cholesterol esterase via hydroge …
Sequential treatment strategies following methotrexate inadequate response in rheumatoid arthritis: a real-world retrospective cohort study.
Cruciani G, Cafaro G, Perricone C, Dal Pozzolo R, Bruno L, Tromby F, Colangelo A, Gerli R, Bartoloni E. Cruciani G, et al. Clin Exp Rheumatol. 2026 May 13. doi: 10.55563/clinexprheumatol/zssu99. Online ahead of print. Clin Exp Rheumatol. 2026. PMID: 42154649
Those failing dose escalation were further stratified into leflunomide (LEF) (n=37) or b/tsDMARD (n=57) groups. Treatment efficacy was assessed using modified EULAR Boolean criteria (3V-remission) at 6-month intervals. ...Similarly, among MTX dose escalation non-responders …
Those failing dose escalation were further stratified into leflunomide (LEF) (n=37) or b/tsDMARD (n=57) groups. Treatment efficacy wa …
The double-edged nature of β-catenin: from multicellular innovation to cancer vulnerability.
Garrido-Faúndez V, Castro-Pereira B, Weil-Echeverría C, Sandoval-Baeza F, Sánchez-González VP, Robinson F, Ravasio A, Owen GI, Bertocchi C. Garrido-Faúndez V, et al. Am J Physiol Cell Physiol. 2026 Jun 1;330(6):C1760-C1774. doi: 10.1152/ajpcell.00175.2026. Epub 2026 May 13. Am J Physiol Cell Physiol. 2026. PMID: 42126086 Free article. Review.
This conserved superhelical structure generates a single interaction groove that mediates mutually exclusive binding to E-cadherin, adenomatous polyposis coli (APC), and T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors. Although this architecture enab …
This conserved superhelical structure generates a single interaction groove that mediates mutually exclusive binding to E-cadherin, adenomat …
3,349 results