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Page 1
The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice.
Barretto SA, Lasserre F, Huillet M, Régnier M, Polizzi A, Lippi Y, Fougerat A, Person E, Bruel S, Bétoulières C, Naylies C, Lukowicz C, Smati S, Guzylack L, Olier M, Théodorou V, Mselli-Lakhal L, Zalko D, Wahli W, Loiseau N, Gamet-Payrastre L, Guillou H, Ellero-Simatos S. Barretto SA, et al. Among authors: huillet m. Microbiome. 2021 Apr 20;9(1):93. doi: 10.1186/s40168-021-01050-9. Microbiome. 2021. PMID: 33879258 Free PMC article.
Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.
Smati S, Polizzi A, Fougerat A, Ellero-Simatos S, Blum Y, Lippi Y, Régnier M, Laroyenne A, Huillet M, Arif M, Zhang C, Lasserre F, Marrot A, Al Saati T, Wan J, Sommer C, Naylies C, Batut A, Lukowicz C, Fougeray T, Tramunt B, Dubot P, Smith L, Bertrand-Michel J, Hennuyer N, Pradere JP, Staels B, Burcelin R, Lenfant F, Arnal JF, Levade T, Gamet-Payrastre L, Lagarrigue S, Loiseau N, Lotersztajn S, Postic C, Wahli W, Bureau C, Guillaume M, Mardinoglu A, Montagner A, Gourdy P, Guillou H. Smati S, et al. Among authors: huillet m. Gut. 2022 Apr;71(4):807-821. doi: 10.1136/gutjnl-2020-323323. Epub 2021 Apr 26. Gut. 2022. PMID: 33903148 Free article.
Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1?
Ben Fradj S, Nédélec E, Salvi J, Fouesnard M, Huillet M, Pallot G, Cansell C, Sanchez C, Philippe C, Gigot V, Lemoine A, Trompier D, Henry T, Petrilli V, Py BF, Guillou H, Loiseau N, Ellero-Simatos S, Nahon JL, Rovère C, Grober J, Boudry G, Douard V, Benani A. Ben Fradj S, et al. Among authors: huillet m. Antioxid Redox Signal. 2022 Aug;37(4-6):349-369. doi: 10.1089/ars.2021.0095. Epub 2022 Apr 20. Antioxid Redox Signal. 2022. PMID: 35166124
The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression.
Fougeray T, Polizzi A, Régnier M, Fougerat A, Ellero-Simatos S, Lippi Y, Smati S, Lasserre F, Tramunt B, Huillet M, Dopavogui L, Salvi J, Nédélec E, Gigot V, Smith L, Naylies C, Sommer C, Haas JT, Wahli W, Duez H, Gourdy P, Gamet-Payrastre L, Benani A, Burnol AF, Loiseau N, Postic C, Montagner A, Guillou H. Fougeray T, et al. Among authors: huillet m. Cell Rep. 2022 Apr 12;39(2):110674. doi: 10.1016/j.celrep.2022.110674. Cell Rep. 2022. PMID: 35417722 Free article.
Dietary Amino Acid Source Elicits Sex-Specific Metabolic Response to Diet-Induced NAFLD in Mice.
Rives C, Martin CMP, Evariste L, Polizzi A, Huillet M, Lasserre F, Alquier-Bacquie V, Perrier P, Gomez J, Lippi Y, Naylies C, Levade T, Sabourdy F, Remignon H, Fafournoux P, Chassaing B, Loiseau N, Guillou H, Ellero-Simatos S, Gamet-Payrastre L, Fougerat A. Rives C, et al. Among authors: huillet m. Mol Nutr Food Res. 2024 Jan;68(1):e2300491. doi: 10.1002/mnfr.202300491. Epub 2023 Oct 27. Mol Nutr Food Res. 2024. PMID: 37888831
Hepatic FGF21 is not required for fasting metabolism but guides protein appetite post energy depletion.
Bruse J, Marbach C, Polizzi A, Landre T, Salvi J, Alquier-Bacquie V, Chen SP, Huillet M, Rives C, Martin CMP, Perrier P, Benhamed F, Régnier M, Weger S, Naylies C, Lippi Y, Sommer C, Albin M, Lasserre F, Levade T, Schupp M, Gamet-Payrastre L, Kautz L, Loiseau N, Wahli W, Ellero-Simatos S, Cruciani-Guglielmacci C, Montagner A, Benani A, Postic C, Guillou H, Fougerat A. Bruse J, et al. Among authors: huillet m. EMBO Rep. 2026 Apr 27. doi: 10.1038/s44319-026-00790-9. Online ahead of print. EMBO Rep. 2026. PMID: 42045447 Free article.
Thermoneutral housing worsens MASLD and reveals defective brown adipose tissue response to β3-adrenergic stimulation.
Martin CMP, Polizzi A, Alquier-Bacquié V, Huillet M, Rives C, Dauriat CJG, Bruse J, Melin V, Naylies C, Lippi Y, Lasserre F, Wan J, Flores-Flores R, Bertrand-Michel J, Blas-Y-Estrada F, Rousseau-Bacquié E, Levade T, Rémignon H, Langin D, Mouisel E, Lotersztajn S, Chassaing B, Gamet-Payrastre L, Guillou H, Ellero-Simatos S, Fougerat A, Loiseau N. Martin CMP, et al. Among authors: huillet m. iScience. 2025 Jul 26;28(9):113221. doi: 10.1016/j.isci.2025.113221. eCollection 2025 Sep 19. iScience. 2025. PMID: 40894885 Free PMC article.
Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling.
Régnier M, Polizzi A, Fougeray T, Fougerat A, Perrier P, Anderson K, Lippi Y, Smati S, Lukowicz C, Lasserre F, Fouche E, Huillet M, Rives C, Tramunt B, Naylies C, Garcia G, Rousseau-Bacquié E, Bertrand-Michel J, Canlet C, Chevolleau-Mege S, Debrauwer L, Heymes C, Burcelin R, Levade T, Gourdy P, Wahli W, Blum Y, Gamet-Payrastre L, Ellero-Simatos S, Guillermet-Guibert J, Hawkins P, Stephens L, Postic C, Montagner A, Loiseau N, Guillou H. Régnier M, et al. Among authors: huillet m. PLoS Biol. 2025 Apr 14;23(4):e3003112. doi: 10.1371/journal.pbio.3003112. eCollection 2025 Apr. PLoS Biol. 2025. PMID: 40228209 Free PMC article.
Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism.
Huillet M, Lasserre F, Gratacap MP, Engelmann B, Bruse J, Polizzi A, Fougeray T, Martin CMP, Rives C, Fougerat A, Naylies C, Lippi Y, Garcia G, Rousseau-Bacquie E, Canlet C, Debrauwer L, Rolle-Kampczyk U, von Bergen M, Payrastre B, Boutet-Robinet E, Gamet-Payrastre L, Guillou H, Loiseau N, Ellero-Simatos S. Huillet M, et al. JHEP Rep. 2023 Oct 13;6(1):100930. doi: 10.1016/j.jhepr.2023.100930. eCollection 2024 Jan. JHEP Rep. 2023. PMID: 38149074 Free PMC article.