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157 results
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Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito.
Garrood WT, Kranjc N, Petri K, Kim DY, Guo JA, Hammond AM, Morianou I, Pattanayak V, Joung JK, Crisanti A, Simoni A. Garrood WT, et al. Among authors: joung jk. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2004838117. doi: 10.1073/pnas.2004838117. Epub 2021 Apr 30. Proc Natl Acad Sci U S A. 2021. PMID: 34050017 Free PMC article.
Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".
Lareau CA, Clement K, Hsu JY, Pattanayak V, Joung JK, Aryee MJ, Pinello L. Lareau CA, et al. Among authors: joung jk. Nat Methods. 2018 Apr;15(4):238-239. doi: 10.1038/nmeth.4541. Epub 2018 Mar 30. Nat Methods. 2018. PMID: 29600992 Free PMC article. No abstract available.
In vivo CRISPR editing with no detectable genome-wide off-target mutations.
Akcakaya P, Bobbin ML, Guo JA, Malagon-Lopez J, Clement K, Garcia SP, Fellows MD, Porritt MJ, Firth MA, Carreras A, Baccega T, Seeliger F, Bjursell M, Tsai SQ, Nguyen NT, Nitsch R, Mayr LM, Pinello L, Bohlooly-Y M, Aryee MJ, Maresca M, Joung JK. Akcakaya P, et al. Among authors: joung jk. Nature. 2018 Sep;561(7723):416-419. doi: 10.1038/s41586-018-0500-9. Epub 2018 Sep 12. Nature. 2018. PMID: 30209390 Free PMC article.
Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq.
Lazzarotto CR, Nguyen NT, Tang X, Malagon-Lopez J, Guo JA, Aryee MJ, Joung JK, Tsai SQ. Lazzarotto CR, et al. Among authors: joung jk. Nat Protoc. 2018 Nov;13(11):2615-2642. doi: 10.1038/s41596-018-0055-0. Nat Protoc. 2018. PMID: 30341435 Free PMC article.
157 results