Keeley TP - Search Results

1

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.

Wing PAC, Keeley TP, Zhuang X, Lee JY, Prange-Barczynska M, Tsukuda S, Morgan SB, Harding AC, Argles ILA, Kurlekar S, Noerenberg M, Thompson CP, Huang KA, Balfe P, Watashi K, Castello A, Hinks TSC, James W, Ratcliffe PJ, Davis I, Hodson EJ, Bishop T, McKeating JA. Wing PAC, et al. Among authors: keeley tp. Cell Rep. 2021 Apr 20;35(3):109020. doi: 10.1016/j.celrep.2021.109020. Epub 2021 Apr 5. Cell Rep. 2021. PMID: 33852916 Free PMC article.

2

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.

Masson N, Keeley TP, Giuntoli B, White MD, Puerta ML, Perata P, Hopkinson RJ, Flashman E, Licausi F, Ratcliffe PJ. Masson N, et al. Among authors: keeley tp. Science. 2019 Jul 5;365(6448):65-69. doi: 10.1126/science.aaw0112. Science. 2019. PMID: 31273118 Free PMC article.

3

Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells.

Tian YM, Holdship P, To TQ, Ratcliffe PJ, Keeley TP. Tian YM, et al. Among authors: keeley tp. J Biol Chem. 2023 Sep;299(9):105156. doi: 10.1016/j.jbc.2023.105156. Epub 2023 Aug 10. J Biol Chem. 2023. PMID: 37572852 Free PMC article.

4

N-terminal cysteine acetylation and oxidation patterns may define protein stability.

Heathcote KC, Keeley TP, Myllykoski M, Lundekvam M, McTiernan N, Akter S, Masson N, Ratcliffe PJ, Arnesen T, Flashman E. Heathcote KC, et al. Among authors: keeley tp. Nat Commun. 2024 Jun 25;15(1):5360. doi: 10.1038/s41467-024-49489-2. Nat Commun. 2024. PMID: 38918375 Free PMC article.

5

Hif-2α programs oxygen chemosensitivity in chromaffin cells.

Prange-Barczynska M, Jones HA, Sugimoto Y, Cheng X, Lima JD, Ratnayaka I, Douglas G, Buckler KJ, Ratcliffe PJ, Keeley TP, Bishop T. Prange-Barczynska M, et al. Among authors: keeley tp. J Clin Invest. 2024 Aug 6;134(18):e174661. doi: 10.1172/JCI174661. J Clin Invest. 2024. PMID: 39106106 Free PMC article.

6

Making sense of oxygen sensing.

Ratcliffe PJ, Keeley TP. Ratcliffe PJ, et al. Among authors: keeley tp. EMBO J. 2025 Sep;44(17):4661-4665. doi: 10.1038/s44318-025-00513-1. Epub 2025 Aug 1. EMBO J. 2025. PMID: 40750701 Free PMC article.

7

Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability.

Kim H, Tian YM, Ratcliffe PJ, Keeley TP. Kim H, et al. Among authors: keeley tp. Proc Natl Acad Sci U S A. 2025 Aug 26;122(34):e2501796122. doi: 10.1073/pnas.2501796122. Epub 2025 Aug 19. Proc Natl Acad Sci U S A. 2025. PMID: 40828020 Free PMC article.

8

A PP2A-mediated feedback mechanism controls Ca²⁺-dependent NO synthesis under physiological oxygen.

Keeley TP, Siow RCM, Jacob R, Mann GE. Keeley TP, et al. FASEB J. 2017 Dec;31(12):5172-5183. doi: 10.1096/fj.201700211R. Epub 2017 Jul 31. FASEB J. 2017. PMID: 28760745 Free PMC article.

9

Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels.

Chapple SJ, Keeley TP, Mastronicola D, Arno M, Vizcay-Barrena G, Fleck R, Siow RCM, Mann GE. Chapple SJ, et al. Among authors: keeley tp. Free Radic Biol Med. 2016 Mar;92:152-162. doi: 10.1016/j.freeradbiomed.2015.12.013. Epub 2015 Dec 15. Free Radic Biol Med. 2016. PMID: 26698668 Free article.

10

Reduced SERCA activity underlies dysregulation of Ca²⁺ homeostasis under atmospheric O₂ levels.

Keeley TP, Siow RCM, Jacob R, Mann GE. Keeley TP, et al. FASEB J. 2018 May;32(5):2531-2538. doi: 10.1096/fj.201700685RRR. Epub 2017 Dec 22. FASEB J. 2018. PMID: 29273673 Free PMC article.

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