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A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.
Virolainen SJ, Creighton K, Dashtiahangar M, Krishnamurthy D, Parks L, Forney C, Ampadu B, Rudrapatna AN, Dunn KA, Parameswaran S, Hesse HK, Chen X, VonHandorf A, Edsall LE, Yin C, Lynch A, Gittens OE, Diouf AA, Jones SH, Hass M, Javier E, Donmez OA, Keddari Y, Danzinger O, Seelamneni H, Namjou-Khales B, Ainsworth HC, Comeau ME, Marion MC, Glenn SB, Nath SK, Freedman BI, Tsao BP, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Reveille JD, James JA, Criswell LA, Vilá LM, Alarcón-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Bae SC, Graham DC, Vyse TJ, Guthridge JM, Gaffney PM, Langefeld CD, Kelly JA, Kaufman KM, Sivils K, Harley JB, Shen N, Lawson LP, Baglaenko Y, Miraldi ER, Rosenberg BR, Siggers T, Waggoner SN, Weirauch MT, Kottyan LC. Virolainen SJ, et al. Among authors: kelly ja. medRxiv [Preprint]. 2026 Jan 22:2026.01.21.26344474. doi: 10.64898/2026.01.21.26344474. medRxiv. 2026. PMID: 41646825 Free PMC article. Preprint.
548 results