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Optogenetic silencing by combining a rhodopsin cyclase with an engineered cGMP-gated potassium channel.
Spreen A, Sadanandan NP, Schneider MW, Kuehn E, Leemisa AN, De Zio R, Meyer N, Busse W, Erlinghagen B, Adenauer L, Opitz T, Bönigk W, Schiewer E, Heer J, Schmitz D, Vierock J, Beck H, Hegemann P, Baier H, Schneider-Warme F, Sierra YAB, Seifert R. Spreen A, et al. Among authors: kuehn e. Sci Adv. 2025 Nov 28;11(48):eadx1195. doi: 10.1126/sciadv.adx1195. Epub 2025 Nov 28. Sci Adv. 2025. PMID: 41313760 Free PMC article.
Cilia to basement membrane signaling is a biomechanical driver in models of autosomal dominant polycystic kidney disease.
Mazloum M, Lapin B, Alghamdi R, Vandensteen J, Burtin M, Houillier P, Cheval L, Crambert G, Scata V, Cohen C, Schell C, Rehman M, Aka A, Ourahmoun K, Benedito R, Kuehn EW, Descroix S, Busch T, Köttgen M, Garbay S, Verpont MC, Tang E, Lelongt B, Cagnard N, Somlo S, Coscoy S, Terzi F, Viau A, Bienaimé F. Mazloum M, et al. Among authors: kuehn ew. J Clin Invest. 2026 Jun 30:e196814. doi: 10.1172/JCI196814. Online ahead of print. J Clin Invest. 2026. PMID: 42378035 Free article.
111 results