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Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade.
Woess K, Macho-Maschler S, Van Ingen Schenau DS, Butler M, Lassnig C, Valcanover D, Poelzl A, Meissl K, Maurer B, Brandstoetter T, Vogl C, Koren A, Kubicek S, Orlova A, Moriggl R, Strobl B, Sexl V, Van Leeuwen FN, Kuiper RP, Mueller M. Woess K, et al. Among authors: kuiper rp. Haematologica. 2023 Apr 1;108(4):993-1005. doi: 10.3324/haematol.2021.279848. Haematologica. 2023. PMID: 35021603 Free PMC article.
BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia.
van Galen JC, Kuiper RP, van Emst L, Levers M, Tijchon E, Scheijen B, Waanders E, van Reijmersdal SV, Gilissen C, van Kessel AG, Hoogerbrugge PM, van Leeuwen FN. van Galen JC, et al. Among authors: kuiper rp. Blood. 2010 Jun 10;115(23):4810-9. doi: 10.1182/blood-2009-05-223081. Epub 2010 Mar 30. Blood. 2010. PMID: 20354172 Free article.
The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution.
Waanders E, Scheijen B, van der Meer LT, van Reijmersdal SV, van Emst L, Kroeze Y, Sonneveld E, Hoogerbrugge PM, van Kessel AG, van Leeuwen FN, Kuiper RP. Waanders E, et al. Among authors: kuiper rp. PLoS Genet. 2012;8(2):e1002533. doi: 10.1371/journal.pgen.1002533. Epub 2012 Feb 16. PLoS Genet. 2012. PMID: 22359517 Free PMC article.
Tumor suppressor IKZF1 mediates glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
Marke R, Havinga J, Cloos J, Demkes M, Poelmans G, Yuniati L, van Ingen Schenau D, Sonneveld E, Waanders E, Pieters R, Kuiper RP, Hoogerbrugge PM, Kaspers GJ, van Leeuwen FN, Scheijen B. Marke R, et al. Among authors: kuiper rp. Leukemia. 2016 Jul;30(7):1599-603. doi: 10.1038/leu.2015.359. Epub 2015 Dec 29. Leukemia. 2016. PMID: 26713593 No abstract available.
Germline activating TYK2 mutations in pediatric patients with two primary acute lymphoblastic leukemia occurrences.
Waanders E, Scheijen B, Jongmans MC, Venselaar H, van Reijmersdal SV, van Dijk AH, Pastorczak A, Weren RD, van der Schoot CE, van de Vorst M, Sonneveld E, Hoogerbrugge N, van der Velden VH, Gruhn B, Hoogerbrugge PM, van Dongen JJ, Geurts van Kessel A, van Leeuwen FN, Kuiper RP. Waanders E, et al. Among authors: kuiper rp. Leukemia. 2017 Apr;31(4):821-828. doi: 10.1038/leu.2016.277. Epub 2016 Oct 13. Leukemia. 2017. PMID: 27733777
Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.
Scheijen B, Boer JM, Marke R, Tijchon E, van Ingen Schenau D, Waanders E, van Emst L, van der Meer LT, Pieters R, Escherich G, Horstmann MA, Sonneveld E, Venn N, Sutton R, Dalla-Pozza L, Kuiper RP, Hoogerbrugge PM, den Boer ML, van Leeuwen FN. Scheijen B, et al. Among authors: kuiper rp. Haematologica. 2017 Mar;102(3):541-551. doi: 10.3324/haematol.2016.153023. Epub 2016 Dec 15. Haematologica. 2017. PMID: 27979924 Free PMC article.
Upfront Treatment Influences the Composition of Genetic Alterations in Relapsed Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.
Yu J, Waanders E, van Reijmersdal SV, Antić Ž, van Bosbeek CM, Sonneveld E, de Groot H, Fiocco M, Geurts van Kessel A, van Leeuwen FN, Pieters R, Hoogerbrugge PM, Kuiper RP. Yu J, et al. Among authors: kuiper rp. Hemasphere. 2020 Jan 22;4(1):e318. doi: 10.1097/HS9.0000000000000318. eCollection 2020 Feb. Hemasphere. 2020. PMID: 32072138 Free PMC article.
Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations.
Antić Ž, Yu J, Van Reijmersdal SV, Van Dijk A, Dekker L, Segerink WH, Sonneveld E, Fiocco M, Pieters R, Hoogerbrugge PM, Van Leeuwen FN, Van Kessel AG, Waanders E, Kuiper RP. Antić Ž, et al. Among authors: kuiper rp. Haematologica. 2021 Dec 1;106(12):3046-3055. doi: 10.3324/haematol.2020.259226. Haematologica. 2021. PMID: 33147938 Free PMC article.
132 results