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Biological activity-based modeling identifies antiviral leads against SARS-CoV-2.
Huang R, Xu M, Zhu H, Chen CZ, Zhu W, Lee EM, He S, Zhang L, Zhao J, Shamim K, Bougie D, Huang W, Xia M, Hall MD, Lo D, Simeonov A, Austin CP, Qiu X, Tang H, Zheng W. Huang R, et al. Among authors: lo d. Nat Biotechnol. 2021 Jun;39(6):747-753. doi: 10.1038/s41587-021-00839-1. Epub 2021 Feb 23. Nat Biotechnol. 2021. PMID: 33623157 Free PMC article.
Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2.
Huang R, Xu M, Zhu H, Chen CZ, Lee EM, He S, Shamim K, Bougie D, Huang W, Hall MD, Lo D, Simeonov A, Austin CP, Qiu X, Tang H, Zheng W. Huang R, et al. Among authors: lo d. bioRxiv [Preprint]. 2020 Jul 27:2020.07.27.223578. doi: 10.1101/2020.07.27.223578. bioRxiv. 2020. Update in: Nat Biotechnol. 2021 Jun;39(6):747-753. doi: 10.1038/s41587-021-00839-1 PMID: 32766591 Free PMC article. Updated. Preprint.
The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators.
Gorshkov K, Chen CZ, Bostwick R, Rasmussen L, Xu M, Pradhan M, Tran BN, Zhu W, Shamim K, Huang W, Hu X, Shen M, Klumpp-Thomas C, Itkin Z, Shinn P, Simeonov A, Michael S, Hall MD, Lo DC, Zheng W. Gorshkov K, et al. Among authors: lo dc. bioRxiv [Preprint]. 2020 May 28:2020.05.16.091520. doi: 10.1101/2020.05.16.091520. bioRxiv. 2020. Update in: ACS Infect Dis. 2021 Jun 11;7(6):1389-1408. doi: 10.1021/acsinfecdis.0c00349 PMID: 32511355 Free PMC article. Updated. Preprint.
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.
Chen CZ, Shinn P, Itkin Z, Eastman RT, Bostwick R, Rasmussen L, Huang R, Shen M, Hu X, Wilson KM, Brooks B, Guo H, Zhao T, Klump-Thomas C, Simeonov A, Michael SG, Lo DC, Hall MD, Zheng W. Chen CZ, et al. Among authors: lo dc. bioRxiv [Preprint]. 2020 Aug 18:2020.08.18.255877. doi: 10.1101/2020.08.18.255877. bioRxiv. 2020. Update in: Front Pharmacol. 2021 Jan 25;11:592737. doi: 10.3389/fphar.2020.592737 PMID: 32839771 Free PMC article. Updated. Preprint.
The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules.
Gorshkov K, Chen CZ, Bostwick R, Rasmussen L, Tran BN, Cheng YS, Xu M, Pradhan M, Henderson M, Zhu W, Oh E, Susumu K, Wolak M, Shamim K, Huang W, Hu X, Shen M, Klumpp-Thomas C, Itkin Z, Shinn P, Carlos de la Torre J, Simeonov A, Michael SG, Hall MD, Lo DC, Zheng W. Gorshkov K, et al. Among authors: lo dc. ACS Infect Dis. 2021 Jun 11;7(6):1389-1408. doi: 10.1021/acsinfecdis.0c00349. Epub 2020 Dec 21. ACS Infect Dis. 2021. PMID: 33346633 Free PMC article.
Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
Shamim K, Xu M, Hu X, Lee EM, Lu X, Huang R, Shah P, Xu X, Chen CZ, Shen M, Guo H, Chen L, Itkin Z, Eastman RT, Shinn P, Klumpp-Thomas C, Michael S, Simeonov A, Lo DC, Ming GL, Song H, Tang H, Zheng W, Huang W. Shamim K, et al. Bioorg Med Chem Lett. 2021 May 15;40:127906. doi: 10.1016/j.bmcl.2021.127906. Epub 2021 Mar 6. Bioorg Med Chem Lett. 2021. PMID: 33689873 Free PMC article.
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.
Chen CZ, Shinn P, Itkin Z, Eastman RT, Bostwick R, Rasmussen L, Huang R, Shen M, Hu X, Wilson KM, Brooks BM, Guo H, Zhao T, Klump-Thomas C, Simeonov A, Michael SG, Lo DC, Hall MD, Zheng W. Chen CZ, et al. Among authors: lo dc. Front Pharmacol. 2021 Jan 25;11:592737. doi: 10.3389/fphar.2020.592737. eCollection 2020. Front Pharmacol. 2021. PMID: 33708112 Free PMC article.
High-Throughput Platform for Novel Reaction Discovery.
Lu X, Luo Z, Huang R, Lo DC, Huang W. Lu X, et al. Chemistry. 2022 Sep 6;28(50):e202201421. doi: 10.1002/chem.202201421. Epub 2022 Jul 21. Chemistry. 2022. PMID: 35766989 Free PMC article.
641 results