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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation.
Richart L, Picod-Chedotel ML, Wassef M, Macario M, Aflaki S, Salvador MA, Héry T, Dauphin A, Wicinski J, Chevrier V, Pastor S, Guittard G, Le Cam S, Kamhawi H, Castellano R, Guasch G, Charafe-Jauffret E, Heard E, Margueron R, Ginestier C. Richart L, et al. Among authors: margueron r. Cell. 2022 Jun 9;185(12):2164-2183.e25. doi: 10.1016/j.cell.2022.04.034. Epub 2022 May 20. Cell. 2022. PMID: 35597241 Free article.
The Multiple Facets of PRC2 Alterations in Cancers.
Wassef M, Margueron R. Wassef M, et al. Among authors: margueron r. J Mol Biol. 2017 Jun 30;429(13):1978-1993. doi: 10.1016/j.jmb.2016.10.012. Epub 2016 Oct 12. J Mol Biol. 2017. PMID: 27742591 Review.
PRC2 is dispensable for HOTAIR-mediated transcriptional repression.
Portoso M, Ragazzini R, Brenčič Ž, Moiani A, Michaud A, Vassilev I, Wassef M, Servant N, Sargueil B, Margueron R. Portoso M, et al. Among authors: margueron r. EMBO J. 2017 Apr 13;36(8):981-994. doi: 10.15252/embj.201695335. Epub 2017 Feb 6. EMBO J. 2017. PMID: 28167697 Free PMC article.
EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer.
Wassef M, Luscan A, Aflaki S, Zielinski D, Jansen PWTC, Baymaz HI, Battistella A, Kersouani C, Servant N, Wallace MR, Romero P, Kosmider O, Just PA, Hivelin M, Jacques S, Vincent-Salomon A, Vermeulen M, Vidaud M, Pasmant E, Margueron R. Wassef M, et al. Among authors: margueron r. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6075-6080. doi: 10.1073/pnas.1814634116. Epub 2019 Mar 13. Proc Natl Acad Sci U S A. 2019. PMID: 30867289 Free PMC article.
EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.
Ragazzini R, Pérez-Palacios R, Baymaz IH, Diop S, Ancelin K, Zielinski D, Michaud A, Givelet M, Borsos M, Aflaki S, Legoix P, Jansen PWTC, Servant N, Torres-Padilla ME, Bourc'his D, Fouchet P, Vermeulen M, Margueron R. Ragazzini R, et al. Among authors: margueron r. Nat Commun. 2019 Aug 26;10(1):3858. doi: 10.1038/s41467-019-11800-x. Nat Commun. 2019. PMID: 31451685 Free PMC article.
79 results