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Reactivity-based screening for natural product discovery.
Harris LA, Mitchell DA. Harris LA, et al. Among authors: mitchell da. Methods Enzymol. 2022;665:177-208. doi: 10.1016/bs.mie.2021.11.018. Epub 2021 Dec 21. Methods Enzymol. 2022. PMID: 35379434 Free PMC article.
Nucleophilic 1,4-additions for natural product discovery.
Cox CL, Tietz JI, Sokolowski K, Melby JO, Doroghazi JR, Mitchell DA. Cox CL, et al. Among authors: mitchell da. ACS Chem Biol. 2014 Sep 19;9(9):2014-22. doi: 10.1021/cb500324n. Epub 2014 Jun 17. ACS Chem Biol. 2014. PMID: 24937678 Free PMC article.
Using Genomics for Natural Product Structure Elucidation.
Tietz JI, Mitchell DA. Tietz JI, et al. Among authors: mitchell da. Curr Top Med Chem. 2016;16(15):1645-94. doi: 10.2174/1568026616666151012111439. Curr Top Med Chem. 2016. PMID: 26456468 Review.
Enzymatic thioamidation of peptide backbones.
Liu A, Krushnamurthy PH, Subramanya KS, Mitchell DA, Mahanta N. Liu A, et al. Among authors: mitchell da. Methods Enzymol. 2021;656:459-494. doi: 10.1016/bs.mie.2021.04.010. Epub 2021 May 11. Methods Enzymol. 2021. PMID: 34325795 Free PMC article.
Bioinformatics-Guided Expansion and Discovery of Graspetides.
Ramesh S, Guo X, DiCaprio AJ, De Lio AM, Harris LA, Kille BL, Pogorelov TV, Mitchell DA. Ramesh S, et al. Among authors: mitchell da. ACS Chem Biol. 2021 Dec 17;16(12):2787-2797. doi: 10.1021/acschembio.1c00672. Epub 2021 Nov 12. ACS Chem Biol. 2021. PMID: 34766760 Free PMC article.
A scalable platform to discover antimicrobials of ribosomal origin.
Ayikpoe RS, Shi C, Battiste AJ, Eslami SM, Ramesh S, Simon MA, Bothwell IR, Lee H, Rice AJ, Ren H, Tian Q, Harris LA, Sarksian R, Zhu L, Frerk AM, Precord TW, van der Donk WA, Mitchell DA, Zhao H. Ayikpoe RS, et al. Among authors: mitchell da. Nat Commun. 2022 Oct 17;13(1):6135. doi: 10.1038/s41467-022-33890-w. Nat Commun. 2022. PMID: 36253467 Free PMC article.
603 results