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Page 1
Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation.
Ivy ZK, Belcher JD, Khasabova IA, Chen C, Juliette JP, Abdulla F, Ruan C, Allen K, Nguyen J, Rogness VM, Beckman JD, Khasabov SG, Gupta K, Taylor RP, Simone DA, Vercellotti GM. Ivy ZK, et al. Blood. 2023 Nov 30;142(22):1918-1927. doi: 10.1182/blood.2022019282. Blood. 2023. PMID: 37774369
Cold exposure also produced mechanical hyperalgesia as measured by paw withdrawal threshold in HbSS mice compared with that in HbAA mice or HbSS mice left at room temperature. ...Anti-C5 or -C5aR mAb infusion also abrogated mechanical hyperalgesia in HbSS mice with …
Cold exposure also produced mechanical hyperalgesia as measured by paw withdrawal threshold in HbSS mice compared with that in HbAA m …
Long-term rehabilitation reduces task error variability in cervical spinal cord contused rats.
Baylo-Marín O, Flores Á, García-Alías G. Baylo-Marín O, et al. Exp Neurol. 2022 Feb;348:113928. doi: 10.1016/j.expneurol.2021.113928. Epub 2021 Nov 20. Exp Neurol. 2022. PMID: 34813841
Long-Evans rats were trained to reach single pellets and then received a moderate 100 kdyn contusion to the C5 lateral funiculi. During the first eight months post-injury, a group of animals was enrolled in daily skilled reaching rehabilitation consisting of grabbing and m …
Long-Evans rats were trained to reach single pellets and then received a moderate 100 kdyn contusion to the C5 lateral funiculi. Duri …
Involvement of 5-HT2A, 5-HT2B and 5-HT2C receptors in mediating the ventrolateral orbital cortex-induced antiallodynia in a rat model of neuropathic pain.
Xu WJ, Wang YY, Zhao Y, Jia H, Tang JS, Huo FQ, Liu H. Xu WJ, et al. Neuroreport. 2020 Jan 27;31(2):167-173. doi: 10.1097/WNR.0000000000001377. Neuroreport. 2020. PMID: 31789691
The present study examined the roles of 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes in mediating the ventrolateral orbital cortex (VLO)-induced antiallodynia in a rat model of neuropathic pain induced by spared nerve injury (SNI). Change of mechanical paw withdrawal thresh …
The present study examined the roles of 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes in mediating the ventrolateral orbital cortex (VLO)-indu …
Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury.
Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ. Gao J, et al. Br J Anaesth. 2019 Dec;123(6):827-838. doi: 10.1016/j.bja.2019.08.026. Epub 2019 Oct 14. Br J Anaesth. 2019. PMID: 31623841 Free PMC article.
We investigated the effect of DEX on the microglial response, and histological and neurological outcomes in a rat model of cervical spinal cord injury. METHODS: Anaesthetised rats underwent unilateral (right) C5 spinal cord contusion (75 kdyne) using an impactor device. Th …
We investigated the effect of DEX on the microglial response, and histological and neurological outcomes in a rat model of cervical spinal c …
Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs.
Hasan M, Marzouk MA, Adhikari S, Wright TD, Miller BP, Matossian MD, Elliott S, Wright M, Alzoubi M, Collins-Burow BM, Burow ME, Holzgrabe U, Zlotos DP, Stratford RE, Witt-Enderby PA. Hasan M, et al. Mol Pharmacol. 2019 Aug;96(2):272-296. doi: 10.1124/mol.119.116202. Epub 2019 Jun 20. Mol Pharmacol. 2019. PMID: 31221824 Free PMC article.
C4 and C5 demonstrated the most favorable pharmacological characteristics with respect to binding profiles (affinity for ESR1 and MT1R) and their potency/efficacy to inhibit BC cell viability and migration in four phenotypically diverse invasive ductal BC cell lines. ...Un …
C4 and C5 demonstrated the most favorable pharmacological characteristics with respect to binding profiles (affinity for ESR1 and MT1 …
Total synthesis of the potent anti-inflammatory natural product solomonamide A along with structural revision and biological activity evaluation.
Jachak GR, Athawale PR, Agarwal H, Barthwal MK, Lauro G, Bifulco G, Reddy DS. Jachak GR, et al. Org Biomol Chem. 2018 Dec 5;16(47):9138-9142. doi: 10.1039/c8ob02713g. Org Biomol Chem. 2018. PMID: 30478463
The challenging task of fixing the stereochemistry of OH at the C5-position was accomplished with the help of DFT calculations, applying a quantum-mechanical (QM)/NMR combined approach. Biological evaluation in a mouse paw edema model revealed that a low dose (0.3 m …
The challenging task of fixing the stereochemistry of OH at the C5-position was accomplished with the help of DFT calculations, apply …
Inflammatory-linked changes in CpG island methylation of three opioid peptide genes in a rat model for pain.
Jacobi CLJ, Stein C. Jacobi CLJ, et al. PLoS One. 2018 Jan 19;13(1):e0191698. doi: 10.1371/journal.pone.0191698. eCollection 2018. PLoS One. 2018. PMID: 29352321 Free PMC article.
Expression of the opioid peptide genes proopiomelanocortin (Pomc), proenkephalin (Penk), and prodynorphin (Pdyn), in immune cells plays a key role in endogenous pain control. In a rat model of painful unilateral paw inflammation, we isolated cells from popliteal lymph node …
Expression of the opioid peptide genes proopiomelanocortin (Pomc), proenkephalin (Penk), and prodynorphin (Pdyn), in immune cells plays a ke …
Longitudinal electrophysiological changes after cervical hemi-contusion spinal cord injury in rats.
Huang Z, Li R, Liu J, Huang Z, Hu Y, Wu X, Zhu Q. Huang Z, et al. Neurosci Lett. 2018 Jan 18;664:116-122. doi: 10.1016/j.neulet.2017.11.019. Epub 2017 Nov 11. Neurosci Lett. 2018. PMID: 29138091
METHODS: Fifteen adult male Sprague-Dawley rats were subjected to the hemi-contusion spinal cord injury at C5. Forelimb MEPs & SEPs were applied to 5 animals before injury and 3h, 1d, 3d, 1w, 2w, 4w and 8w after injury respectively. ...At 8 weeks after injury, the ipsi …
METHODS: Fifteen adult male Sprague-Dawley rats were subjected to the hemi-contusion spinal cord injury at C5. Forelimb MEPs & SE …
Evaluation of the anatomical and functional consequences of repetitive mild cervical contusion using a model of spinal concussion.
Jin Y, Bouyer J, Haas C, Fischer I. Jin Y, et al. Exp Neurol. 2015 Sep;271:175-88. doi: 10.1016/j.expneurol.2015.06.001. Epub 2015 Jun 10. Exp Neurol. 2015. PMID: 26070306 Free PMC article.
Rats received a very mild (50 kdyn, IH impactor) spinal contusion at C5 and were separated into two groups three weeks after the initial injury--C1, which received a second, sham surgery, and C2, which received a second contusion at the same site. ...The cylinder test show …
Rats received a very mild (50 kdyn, IH impactor) spinal contusion at C5 and were separated into two groups three weeks after the init …
Pharmacological insight into the anti-inflammatory activity of sesquiterpene lactones from Neurolaena lobata (L.) R.Br. ex Cass.
McKinnon R, Binder M, Zupkó I, Afonyushkin T, Lajter I, Vasas A, de Martin R, Unger C, Dolznig H, Diaz R, Frisch R, Passreiter CM, Krupitza G, Hohmann J, Kopp B, Bochkov VN. McKinnon R, et al. Phytomedicine. 2014 Oct 15;21(12):1695-701. doi: 10.1016/j.phymed.2014.07.019. Epub 2014 Sep 15. Phytomedicine. 2014. PMID: 25442279
In vivo anti-inflammatory activity of the chemically characterized extract was evaluated using carrageenan-induced paw edema model in rats. RESULTS: The compounds and extract inhibited LPS- and TNF-alpha-induced upregulation of the pro-inflammatory molecules E-selectin and …
In vivo anti-inflammatory activity of the chemically characterized extract was evaluated using carrageenan-induced paw edema model in …
34 results