Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation.
Ivy ZK, Belcher JD, Khasabova IA, Chen C, Juliette JP, Abdulla F, Ruan C, Allen K, Nguyen J, Rogness VM, Beckman JD, Khasabov SG, Gupta K, Taylor RP, Simone DA, Vercellotti GM.
Ivy ZK, et al.
Blood. 2023 Nov 30;142(22):1918-1927. doi: 10.1182/blood.2022019282.
Blood. 2023.
PMID: 37774369
Cold exposure also produced mechanical hyperalgesia as measured by paw withdrawal threshold in HbSS mice compared with that in HbAA mice or HbSS mice left at room temperature. ...Anti-C5 or -C5aR mAb infusion also abrogated mechanical hyperalgesia in HbSS mice with …
Cold exposure also produced mechanical hyperalgesia as measured by paw withdrawal threshold in HbSS mice compared with that in HbAA m …