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2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms.
Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T. Freund I, et al. Among authors: pichot f. RNA. 2019 Jul;25(7):869-880. doi: 10.1261/rna.070243.118. Epub 2019 Apr 24. RNA. 2019. PMID: 31019095 Free PMC article.
Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines.
Pichot F, Hogg MC, Marchand V, Bourguignon V, Jirström E, Farrell C, Gibriel HA, Prehn JHM, Motorin Y, Helm M. Pichot F, et al. Comput Struct Biotechnol J. 2022 Dec 19;21:401-417. doi: 10.1016/j.csbj.2022.12.020. eCollection 2023. Comput Struct Biotechnol J. 2022. PMID: 36618980 Free PMC article.
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