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Page 1
Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.
Haston S, Gonzalez-Gualda E, Morsli S, Ge J, Reen V, Calderwood A, Moutsopoulos I, Panousopoulos L, Deletic P, Carreno G, Guiho R, Manshaei S, Gonzalez-Meljem JM, Lim HY, Simpson DJ, Birch J, Pallikonda HA, Chandra T, Macias D, Doherty GJ, Rassl DM, Rintoul RC, Signore M, Mohorianu I, Akbar AN, Gil J, Muñoz-Espín D, Martinez-Barbera JP. Haston S, et al. Among authors: rassl dm. Cancer Cell. 2023 Jul 10;41(7):1242-1260.e6. doi: 10.1016/j.ccell.2023.05.004. Epub 2023 Jun 1. Cancer Cell. 2023. PMID: 37267953 Free article.
Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.
Kahles A, Lehmann KV, Toussaint NC, Hüser M, Stark SG, Sachsenberg T, Stegle O, Kohlbacher O, Sander C; Cancer Genome Atlas Research Network; Rätsch G. Kahles A, et al. Cancer Cell. 2018 Aug 13;34(2):211-224.e6. doi: 10.1016/j.ccell.2018.07.001. Epub 2018 Aug 2. Cancer Cell. 2018. PMID: 30078747 Free PMC article.
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome.
González-Gualda E, Reinius MAV, Macias D, Morsli S, Ge J, Olan I, Martín JE, Ou HL, Hartono M, Puerto-Camacho MP, Denholm M, Kieran R, Hoffmann R, Dane M, Veroutis D, Medrano G, Mulero F, Jimenez-Linan M, Fruk L, Martins CP, Barbacid M, Gorgoulis V, Korkola JE, Rassl DM, Doherty GJ, Rintoul RC, Narita M, Brenton JD, Muñoz-Espín D. González-Gualda E, et al. Among authors: rassl dm. Nat Aging. 2026 Feb 3. doi: 10.1038/s43587-025-01054-2. Online ahead of print. Nat Aging. 2026. PMID: 41634464
Somatic mutation and selection at population scale.
Lawson ARJ, Abascal F, Nicola PA, Lensing SV, Roberts AL, Kalantzis G, Baez-Ortega A, Brzozowska N, El-Sayed Moustafa JS, Vaitkute D, Jakupovic B, Nessa A, Wadge S, Österdahl MF, Paterson AL, Rassl DM, Alcantara RE, O'Neill L, Widaa S, Austin-Guest S, Neville MDC, Przybilla MJ, Cheng W, Morra M, Sykes L, Mayho M, Müller-Sienerth N, Williams N, Alexander D, Harvey LMR, Clarke T, Byrne A, Blundell JR, Young MD, Mahbubani KTA, Saeb-Parsy K, Martin HC, Stratton MR, Campbell PJ, Rahbari R, Small KS, Martincorena I. Lawson ARJ, et al. Among authors: rassl dm. Nature. 2025 Nov;647(8089):411-420. doi: 10.1038/s41586-025-09584-w. Epub 2025 Oct 8. Nature. 2025. PMID: 41062696 Free PMC article.
Methodology for generating chorioallantoic membrane patient-derived xenograft (CAM-PDX) models of pleural mesothelioma and performing preclinical imaging for the translation of cancer studies and drug screening.
Schulze J, Barnett S, Shaw L, Herrmann A, Poptani H, Rassl DM, Haragan A, Shackcloth M, Sacco JJ, Coulson JM. Schulze J, et al. Among authors: rassl dm. F1000Res. 2025 Aug 14;14:481. doi: 10.12688/f1000research.163596.2. eCollection 2025. F1000Res. 2025. PMID: 40568242 Free PMC article.
Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma.
Obacz J, Valer JA, Nibhani R, Adams TS, Schupp JC, Veale N, Lewis-Wade A, Flint J, Hogan J, Aresu G, Coonar AS, Peryt A, Biffi G, Kaminski N, Francies H, Rassl DM, Garnett MJ, Rintoul RC, Marciniak SJ. Obacz J, et al. Among authors: rassl dm. Eur Respir J. 2024 Jan 25;63(1):2300143. doi: 10.1183/13993003.00143-2023. Print 2024 Jan. Eur Respir J. 2024. PMID: 38212075 Free PMC article.
BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification.
Barnett SE, Kenyani J, Tripari M, Butt Z, Grosman R, Querques F, Shaw L, Silva LC, Goate Z, Marciniak SJ, Rassl DM, Jackson R, Lian LY, Szlosarek PW, Sacco JJ, Coulson JM. Barnett SE, et al. Among authors: rassl dm. Mol Cancer Res. 2023 May 1;21(5):411-427. doi: 10.1158/1541-7786.MCR-22-0635. Mol Cancer Res. 2023. PMID: 36669126 Free PMC article.
Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer.
Gale D, Heider K, Ruiz-Valdepenas A, Hackinger S, Perry M, Marsico G, Rundell V, Wulff J, Sharma G, Knock H, Castedo J, Cooper W, Zhao H, Smith CG, Garg S, Anand S, Howarth K, Gilligan D, Harden SV, Rassl DM, Rintoul RC, Rosenfeld N. Gale D, et al. Among authors: rassl dm. Ann Oncol. 2022 May;33(5):500-510. doi: 10.1016/j.annonc.2022.02.007. Epub 2022 Mar 17. Ann Oncol. 2022. PMID: 35306155 Free PMC article.
Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis.
Field JK, Vulkan D, Davies MPA, Baldwin DR, Brain KE, Devaraj A, Eisen T, Gosney J, Green BA, Holemans JA, Kavanagh T, Kerr KM, Ledson M, Lifford KJ, McRonald FE, Nair A, Page RD, Parmar MKB, Rassl DM, Rintoul RC, Screaton NJ, Wald NJ, Weller D, Whynes DK, Williamson PR, Yadegarfar G, Gabe R, Duffy SW. Field JK, et al. Among authors: rassl dm. Lancet Reg Health Eur. 2021 Sep 11;10:100179. doi: 10.1016/j.lanepe.2021.100179. eCollection 2021 Nov. Lancet Reg Health Eur. 2021. PMID: 34806061 Free PMC article.
71 results