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Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2.
Qiao Y, Wang XM, Mannan R, Pitchiaya S, Zhang Y, Wotring JW, Xiao L, Robinson DR, Wu YM, Tien JC, Cao X, Simko SA, Apel IJ, Bawa P, Kregel S, Narayanan SP, Raskind G, Ellison SJ, Parolia A, Zelenka-Wang S, McMurry L, Su F, Wang R, Cheng Y, Delekta AD, Mei Z, Pretto CD, Wang S, Mehra R, Sexton JZ, Chinnaiyan AM. Qiao Y, et al. Among authors: sexton jz. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2021450118. doi: 10.1073/pnas.2021450118. Epub 2020 Dec 28. Proc Natl Acad Sci U S A. 2021. PMID: 33310900 Free PMC article.
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19.
Mirabelli C, Wotring JW, Zhang CJ, McCarty SM, Fursmidt R, Frum T, Kadambi NS, Amin AT, O'Meara TR, Pretto CD, Spence JR, Huang J, Alysandratos KD, Kotton DN, Handelman SK, Wobus CE, Weatherwax KJ, Mashour GA, O'Meara MJ, Sexton JZ. Mirabelli C, et al. Among authors: sexton jz. bioRxiv [Preprint]. 2020 Dec 7:2020.05.27.117184. doi: 10.1101/2020.05.27.117184. bioRxiv. 2020. Update in: Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105815118. doi: 10.1073/pnas.2105815118. PMID: 32577649 Free PMC article. Updated. Preprint.
Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19.
Mirabelli C, Wotring JW, Zhang CJ, McCarty SM, Fursmidt R, Pretto CD, Qiao Y, Zhang Y, Frum T, Kadambi NS, Amin AT, O'Meara TR, Spence JR, Huang J, Alysandratos KD, Kotton DN, Handelman SK, Wobus CE, Weatherwax KJ, Mashour GA, O'Meara MJ, Chinnaiyan AM, Sexton JZ. Mirabelli C, et al. Among authors: sexton jz. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2105815118. doi: 10.1073/pnas.2105815118. Proc Natl Acad Sci U S A. 2021. PMID: 34413211 Free PMC article.
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases.
Chigumba DN, Mydy LS, de Waal F, Li W, Shafiq K, Wotring JW, Mohamed OG, Mladenovic T, Tripathi A, Sexton JZ, Kautsar S, Medema MH, Kersten RD. Chigumba DN, et al. Among authors: sexton jz. Nat Chem Biol. 2022 Jan;18(1):18-28. doi: 10.1038/s41589-021-00892-6. Epub 2021 Nov 22. Nat Chem Biol. 2022. PMID: 34811516
Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes.
Yao Y, Subedi K, Liu T, Khalasawi N, Pretto-Kernahan CD, Wotring JW, Wang J, Yin C, Jiang A, Fu C, Dimitrion P, Li J, Veenstra J, Yi Q, McKinnon K, McKinnon JE, Sexton JZ, Zhou L, Mi QS. Yao Y, et al. Among authors: sexton jz. Cell Discov. 2022 Sep 9;8(1):89. doi: 10.1038/s41421-022-00453-8. Cell Discov. 2022. PMID: 36085197 Free PMC article.
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